The development of intrinsically stretchable organic electrochemical synaptic transistors(ISOESTs)based entirely on elastomeric materials is pivotal for advancing applications requiring neuromorphic functionality unde...The development of intrinsically stretchable organic electrochemical synaptic transistors(ISOESTs)based entirely on elastomeric materials is pivotal for advancing applications requiring neuromorphic functionality under significant mechanical deformation.This study presents ISOESTs capable of replicating a comprehensive range of synaptic behaviors,including excitatory postsynaptic currents(EPSCs),paired-pulse facilitation(PPF),and transitions from short-term memory(STM)to long-term memory(LTM).Remarkably,these synaptic characteristics were preserved even when the devices were subjected to 30%uniaxial strain,demonstrating exceptional mechanical robustness and functional stability.A pixelated 5×5 array of ISOESTs exhibited minimal device-to-device variation,underscoring the scalability and uniformity of the fabrication approach.To further illustrate their potential,a neurologically integrated electronic skin(e-skin)was fabricated,incorporating these ISOESTs to enable modulation of synaptic responses.The modulation of synaptic responses was strongly correlated with electrochemical analyses,establishing a robust operational framework for programmable neuromorphic systems.Comprehensive investigations into device fabrication,operation mechanisms,and integration strategies provide critical insights into the potential of these systems for next-generation applications in wearable electronics,soft robotics,neuro-prosthetics,and human–machine interfaces.This work represents a significant step toward realizing adaptive,biologically inspired electronic platforms capable of bridging the gap between engineered systems and living tissues.展开更多
Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hip...Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using an in vivo field recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest that in vivo field recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.展开更多
基金supported by a New Faculty Research Grant of Pusan National University,2023support from the National Research Foundation of Korea(NRF)(Nos.RS-2023-00222166 and RS-2025-00558955).
文摘The development of intrinsically stretchable organic electrochemical synaptic transistors(ISOESTs)based entirely on elastomeric materials is pivotal for advancing applications requiring neuromorphic functionality under significant mechanical deformation.This study presents ISOESTs capable of replicating a comprehensive range of synaptic behaviors,including excitatory postsynaptic currents(EPSCs),paired-pulse facilitation(PPF),and transitions from short-term memory(STM)to long-term memory(LTM).Remarkably,these synaptic characteristics were preserved even when the devices were subjected to 30%uniaxial strain,demonstrating exceptional mechanical robustness and functional stability.A pixelated 5×5 array of ISOESTs exhibited minimal device-to-device variation,underscoring the scalability and uniformity of the fabrication approach.To further illustrate their potential,a neurologically integrated electronic skin(e-skin)was fabricated,incorporating these ISOESTs to enable modulation of synaptic responses.The modulation of synaptic responses was strongly correlated with electrochemical analyses,establishing a robust operational framework for programmable neuromorphic systems.Comprehensive investigations into device fabrication,operation mechanisms,and integration strategies provide critical insights into the potential of these systems for next-generation applications in wearable electronics,soft robotics,neuro-prosthetics,and human–machine interfaces.This work represents a significant step toward realizing adaptive,biologically inspired electronic platforms capable of bridging the gap between engineered systems and living tissues.
文摘Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion. Therefore, we investigated the effect of isoflurane on the hippocampus and cortex using an in vivo field recording approach. Our results showed that 1.3%, 0.8%, and 0.4% isoflurane exerted an inhibitory influence on the mouse hippocampus and cortex. Further, high frequency bands in the cortex and hippocampus showed greater suppression with increasing isoflurane concentration. Our findings suggest that in vivo field recordings can monitor the effect of isoflurane anesthesia on the mouse cortex and hippocampus.
