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An optimal design of the liquid-cooling plate channel in a power battery based on response surface methodology
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作者 Jinbo Zheng Jibin Jiang +2 位作者 Xiwei Yu Bingjun Yan Guofu Lian 《中国科学技术大学学报》 北大核心 2025年第2期52-65,51,I0002,共16页
The work takes a new liquid-cooling plate in a power battery with pin fins inside the channel as the object.A mathematical model is established via the central composite design of the response surface to study the rel... The work takes a new liquid-cooling plate in a power battery with pin fins inside the channel as the object.A mathematical model is established via the central composite design of the response surface to study the relationships among the length,width,height,and spacing of pin fins;the maximum temperature and temperature difference of the battery module;and the pressure drop of the liquid-cooling plate.Model accuracy is verified via variance analysis.The new liquid-cooling plate enables the power battery to work within an optimal temperature range.Appropriately increasing the length,width,and height and reducing the spacing of pin fins could reduce the temperature of the power battery module and improve the temperature uniformity.However,the pressure drop of the liquid-cooling plate increases.The structural parameters of the pin fins are optimized to minimize the maximum temperature and the temperature difference of the battery module as well as the pressure drop of the liquid-cooling plate.The errors between the values predicted and actual by the simulation test are 0.58%,4%,and 0.48%,respectively,which further verifies the model accuracy.The results reveal the influence of the structural parameters of the pin fins inside the liquid-cooling plate on its heat dissipation performance and pressure drop characteristics.A theoretical basis is provided for the design of liquid-cooling plates in power batteries and the optimization of structural parameters. 展开更多
关键词 response surface methodology power battery cooling channel optimal design
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Optimization of methanol distillation process using response surface methodology
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作者 Xuefeng Feng Xuan Du +4 位作者 Shaolan Zhuang Zhongwei Ding Hongkang Zhao Qunsheng Li Yuxin Li 《Chinese Journal of Chemical Engineering》 2025年第10期164-176,共13页
This study employed the Box-Behnken design in response surface methodology(RSM)to optimize predistillation and pressurized distillation column parameters in methanol distillation.Statistical and fittinganalyses demons... This study employed the Box-Behnken design in response surface methodology(RSM)to optimize predistillation and pressurized distillation column parameters in methanol distillation.Statistical and fittinganalyses demonstrated the effects of operational parameters and their interactions on product purity and operating costs.Results showed that for methanol mass fraction in the product,the top distillate of the predistillation column(D_(1)),the interaction between D_(1) and the top distillate of the pressurized distillation column(D_(2)),and the interaction between the theoretical plates of the pressurized distillation column(N_(2))and its refluxratio(R_(2))significantlyaffected the outcome,in addition to pressurized distillation column parameters.Acetone mass fraction was mainly influencedby predistillation column parameters and their interactions,with minimal relation to the pressurized distillation column.Operating costs were primarily affected by the refluxratio(R),withdrawal(D)of both columns,and their interactions.Optimization strategies involved increasing theoretical plates and reducing refluxratios compared to the initial plan,achieving energy-saving and consumption-reduction goals.The process required the pressurized distillation column‘s methanol mass fraction to exceed 99.80%,acetone mass fraction below 2×10^(-8),and formaldehyde mass fraction below 5×10^(-9),with a feed rate of 6100 kg·h^(-1).Plans A,B,and C achieved energy-savings of 29.80%,21.78%,and 25.50%respectively,while ensuring separation efficiencyand product quality.This research provides theoretical and practical guidance for optimizing the methanol distillation process,helping to reduce energy consumption and production costs,thereby enhancing corporate competitiveness. 展开更多
关键词 Methanol distillation Response surface methodology Box-Behnken design Parameter optimization Energy-saving and consumption reduction Operating cost
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Optimization and mechanism analysis of multi-solid wastes-based geopolymer using response surface methodology
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作者 Muyang Huang Shenxu Bao +3 位作者 Yimin Zhang Mengke Li Chong Deng Wenhan Chen 《International Journal of Minerals,Metallurgy and Materials》 2025年第6期1345-1357,共13页
The escalating production of industrial solid waste,combined with the dwindling availability of natural resources,has intensified the focus on waste recycling.However,the heterogeneity and complexity of waste pose sig... The escalating production of industrial solid waste,combined with the dwindling availability of natural resources,has intensified the focus on waste recycling.However,the heterogeneity and complexity of waste pose significant challenges to determining process parameters.In this study,burnt coal cinder(BCC),granite powder(GP),and high-calcium fly ash(Class-C FA)were used as raw materials,and the response surface methodology(RSM)and single-factor experiments were applied to optimize the process parameters for geopolymer preparation.The optimized precursor powder composition was determined to be a mass ratio of 1.6:0.9:7.3 for BCC,GP,and Class-C FA.The NaOH-precursor powder ratio and liquid-solid ratio were adjusted to 0.084 and 0.222,respectively.The curing condition was set at 80℃ for 24 h.The resulting 28 d-aged multi-solid wastes-based geopolymer exhibited a high compressive strength of61.34 MPa.The microstructure,mineral phase,and atomic bonding of geopolymers were investigated using X-ray diffraction(XRD),thermal analysis(TA),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscopy with energy dispersive spectroscopy(SEM-EDS).Findings indicate that the compressive strength of geopolymer is most significantly influenced by the Class-C FA,followed by BCC.Furthermore,a minor addition of GP can optimize the structural density of the geopolymer.The Ca present in the Class-C FA participates in the geopolymerization,forming a hybrid N-(C)-A-S-H gel.RSM optimization facilitates the synergistic utilization of multi-solid wastes,ensuring an even distribution of gel and filler.This research establishes a theoretical framework for optimizing the preparation parameters of multi-solid wastes-based geopolymer and its subsequent applications;it holds significant scientific implications for the circular economy,resource transformation,and environmental conservation. 展开更多
关键词 multi-solid wastes GEOPOLYMER response surface methodology process parameters synergistic effect
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Optimal amino acid system for early embryo development in sows based on response surface methodology and high-throughput screening cell models
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作者 Xinyu Wang Jun Huang +12 位作者 Yanlong Li Zhekun Zhu Bangxin Xue Yueyang Meng Jiale Bao Ran Ning Siyu Li Fang Chen Shihai Zhang Xiangzhou Zeng Shuang Cai Chuanjiang Cai Xiangfang Zeng 《Journal of Animal Science and Biotechnology》 2025年第3期1324-1340,共17页
Background Early embryo development plays a pivotal role in determining pregnancy outcomes,postnatal development,and lifelong health.Therefore,the strategic selection of functional nutrients to enhance embryo developm... Background Early embryo development plays a pivotal role in determining pregnancy outcomes,postnatal development,and lifelong health.Therefore,the strategic selection of functional nutrients to enhance embryo development is of paramount importance.In this study,we established a stable porcine trophectoderm cell line expressing dual fluorescent reporter genes driven by the CDX2 and TEAD4 gene promoter segments using lentiviral transfection.Results Three amino acid metabolites—kynurenic acid,taurine,and tryptamine—met the minimum z-score criteria of 2.0 for both luciferase and Renilla luciferase activities and were initially identified as potential metabolites for embryo development,with their beneficial effects validated by qPCR.Given that the identified metabolites are closely related to methionine,arginine,and tryptophan,we selected these three amino acids,using lysine as a standard,and employed response surface methodology combined with our high-throughput screening cell model to efficiently screen and optimize amino acid combination conducive to early embryo development.The optimized candidate amino acid system included lysine(1.87 mmol/L),methionine(0.82 mmol/L),tryptophan(0.23 mmol/L),and arginine(3 mmol/L),with the ratio of 1:0.43:0.12:1.60.In vitro experiments confirmed that this amino acid system enhances the expression of key genes involved in early embryonic development and improves in vitro embryo adhesion.Transcriptomic analysis of blastocysts suggested that candidate amino acid system enhances early embryo development by regulating early embryonic cell cycle and differentiation,as well as improving nutrient absorption.Furthermore,based on response surface methodology,400 sows were used to verify this amino acid system,substituting arginine with the more cost-effective N-carbamoyl glutamate(NCG),a precursor of arginine.The optimal dietary amino acid requirement was predicted to be 0.71%lysine,0.32%methionine,0.22%tryptophan,and 0.10%NCG for sows during early gestation.The optimized amino acid system ratio of the feed,derived from the peripheral release of essential amino acids,was found to be 1:0.45:0.13,which is largely consistent with the results obtained from the cell model optimization.Subsequently,we furtherly verified that this optimal dietary amino acid system significantly increased total litter size,live litter size and litter weight in sows.Conclusions In summary,we successfully established a dual-fluorescent high-throughput screening cell model for the efficient identification of potential nutrients that would promote embryo development and implantation.This innovative approach overcomes the limitations of traditional amino acid nutrition studies in sows,providing a more effective model for enhancing reproductive outcomes. 展开更多
关键词 Amino acid Embryonic development High throughput screening NUTRIENT Response surface methodology
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Study on the optimization of the mechanica properties of engineered desulfurization gypsum composites using response surface methodology
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作者 TAN Yan ZHOU Lijun +2 位作者 YU Jiangtao XIAO Henglin LONG Xiong 《Journal of Southeast University(English Edition)》 2025年第1期58-66,共9页
Practical applications of desulfurization gypsum are limited owing to its brittleness and low strength.To overcome these challenges,researchers have developed engineered desulfurization gypsum composites(EDGCs)by inco... Practical applications of desulfurization gypsum are limited owing to its brittleness and low strength.To overcome these challenges,researchers have developed engineered desulfurization gypsum composites(EDGCs)by incorporating ultrahigh molecular weight polyethylene(UHMWPE)fiber and sulfoaluminate cement(SAC).The mix ratio was optimized using response surface methodology(RSM).Experimental testing of EDGC under compressive and tensile loads led to the creation of a regression model that investigates the influence of variables and their interactions on the material’s compressive and tensile strengths.Additionally,microscopic morphology and hydration product composition were analyzed to explore the influence mechanism.The results indicated that EDGC’s compressive strength increased by up to 38.4%owing to a decreased water-binder ratio and higher SAC content.Similarly,tensile strength increased by up to 38.6%owing to increased SAC and fiber content.Moreover,EDGC demonstrated excellent strain-hardening behavior and multiple cracking characteristics,achieving a maximum tensile strain of nearly 3%.The research findings provide valuable insights for optimizing the performance of desulfurization gypsum. 展开更多
关键词 engineered desulfurization gypsum composites(EDGC) response surface methodology(RSM) INTERACTION compressive strength tensile strength STRAIN-HARDENING
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Soft computing applications in asphalt pavement:A comprehensive review of data-driven techniques using response surface methodology and machine learning
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作者 Nura Shehu Aliyu Yaro Muslich Hartadi Sutanto +6 位作者 Mohd Rosli Hainin Noor Zainab Habib Aliyu Usman Muhammad Sani Bello Surajo Abubakar Wada Abiola Usman Adebanjo Ahmad Hussaini Jagaba 《Journal of Road Engineering》 2025年第2期129-163,共35页
The asphalt pavement industry is transforming because of the growing influence of artificial intelligence and industrial digitization.As a result of this shift,there is a stronger emphasis on advanced statistical appr... The asphalt pavement industry is transforming because of the growing influence of artificial intelligence and industrial digitization.As a result of this shift,there is a stronger emphasis on advanced statistical approaches like optimization tools like response surface methodology(RSM)and machine learning(ML)techniques.The goal of this paper is to provide a scientometric and systematic review of the application of RSM and ML applications in data-driven approaches such as optimizing,modeling,and predicting asphalt pavement performance to achieve sustainable asphalt pavements in support of numerous sustainable development goals(SDGs).These include Goals 9(sustainable infrastructure),11(urban resilience),12(sustainable construction strategies),13(climate action through optimized materials),and 17(multidisciplinary interaction).A thorough search of the ScienceDirect,Web of Science,and Scopus databases from 2010 to 2023 yielded 1249 relevant records,with 125 studies closely examined.Over the last thirteen years,there has been significant research growth in RSM and ML applications,particularly in ML-based pavement optimization.The study shows that the topic has a global presence,with notable contributions from Asia,North America,Europe,and other continents.Researchers have concentrated on utilizing sophisticated ML models such as support vector machines(SVM),artificial neural networks(ANN),and Bayesian networks for prediction.Also,the integration of RSM and ML provides a faster and more efficient method for analyzing large datasets to optimize asphalt pavement performance variables.Key contributors include the United States,China,and Malaysia,with global efforts focused on sustainable materials and approaches to reduce impact on the environment.Furthermore,the review demonstrates the integrated use of RSM and ML as transformative tools for improving sustainability,which contributes significantly to SDGs 9,11,12,13,and 17.Providing valuable insights for future research and guiding decision-making for soft computing applications for asphalt pavement projects. 展开更多
关键词 Response surface methodology Machine learning Asphalt pavement Optimization soft computing PREDICTION
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Optimization of defoaming-flocculation-dewatering indices of earth pressure balance(EPB)shield muck using response surface methodology and desirability approach
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作者 Yao Lu Ming Huang +3 位作者 Chengzhao Zhang Bingnan Wang Liqian Peng Wei Wei 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期1134-1148,共15页
In situ recycling is one of the most effective methods to dispose of earth pressure balance(EPB)shield waste muck with residual foaming agents with high moisture content.In this context,response surface methodology(RS... In situ recycling is one of the most effective methods to dispose of earth pressure balance(EPB)shield waste muck with residual foaming agents with high moisture content.In this context,response surface methodology(RSM)was employed to quantify the effects of independent variables,including flocculant dosage,defoamer dosage,and muck drying mass(MDM)and their interactions on defoaming-flocculation-dewatering indices.The polymeric aluminum chloride(PACL)and hydroxy silicone oil-glycerol polypropylene ether(H-G)were selected as the flocculant and defoamer.The contents of surfactants and foam stabilizers in residual foaming agents were determined using the proposed empirical equation.The defoaming ratio,antifoaming ratio,turbidity,moisture content,filtration loss ratio,and fall cone penetration depth were considered as dependent variables.The accuracy of developed RSM models was verified by the analysis results of variance,residuals,and paired t-test.Combined with the desirability approach,an optimal mixing ratio of 0.078 wt%PACL,0.016 wt%H-G,and 27.882 wt%MDM was recommended,leading to a defoaming ratio of 98.34 vol%for residual foams and a moisture content of 56.72 wt%for pressure-filtration cakes.Our findings were demonstrated to be able to provide useful guidance for prediction and optimization of the in situ recycling indicators of EPB shield waste muck in metro tunnel construction sites. 展开更多
关键词 Desirability approach EPB shield Muck recycling Multiobjective optimization Response surface methodology(RSM)
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Research on the Cymbidium tortisepalum var.longibracteatum Growth and Non-Tube Rapid Propagation Based on Response Surface Methodology
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作者 Guolan Wang Ting Xie +2 位作者 Lijun Fu Siying Qu Jie Li 《Phyton-International Journal of Experimental Botany》 2025年第3期953-971,共19页
The objective of this study was to determine the optimal proportions of plant growth regulators for growth and non-tube rapid propagation of Cymbidium tortisepalum var. longibracteatum;seedlings were utilized as the m... The objective of this study was to determine the optimal proportions of plant growth regulators for growth and non-tube rapid propagation of Cymbidium tortisepalum var. longibracteatum;seedlings were utilized as the material. The effects of various combinations and concentrations of 6-benzylaminopurine (6-BA), gibberellic acid (GA_(3)), and naphthaleneacetic acid (NAA) on growth and non-tube rapid propagation were assessed through a single-factor testing and response surface methodology. The results indicated that 6-BA at 60 mg/L, GA_(3) at 150 mg/L, and NAA at 30 mg/L were the most effective concentrations for promoting leaf buds formation in the single-factor analysis. Response surface methodology clarified the sensitivity of the proliferation rate of lateral buds to the three factors, with 6-BA being the most influential, followed by GA_(3) and NAA. The increase in leaf area was most significantly influenced by NAA, then GA_(3), and least by 6-BA, while the increase in plant height was most responsive to GA_(3), followed by 6-BA, and then NAA. The ideal concentrations of plant growth regulators were established as 6-BA at 43 mg/L, GA_(3) at 169 mg/L, and NAA at 36 mg/L. Under these conditions, the lateral bud number per plant was 2.78, with a leaf area increment of 2.87 cm2 and a plant height increment of 2.67 cm. 展开更多
关键词 Cymbidium tortisepalum var.longibracteatum GROWTH non-tube rapid propagation response surface methodology plant growth regulator
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Optimization of the Crystallization Process for Ceftriaxone Sodium, a Third-Generation Cephalosporin, Utilizing Response Surface Methodology
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作者 Yanxi LAI Furong ZHANG +4 位作者 Jingyue ZHU Hao LIU Yizhang WANG Jing LI Shengjiu GU 《Medicinal Plant》 2025年第2期14-18,共5页
[Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key ... [Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key factors, including crystallization temperature, stirring speed, solvent drop rate, and seed crystal content, were employed as independent variables, while the crystallization rate served as the response variable. The Box-Behnken response surface method was utilized for the optimization design. [Results] The optimal parameters for the crystallization process, determined through optimization, were as follows: a temperature of 10.6 ℃, a stirring rate of 150 rpm, a solvent drop rate of 1.50 mL/min, and a seed crystal content of 0.12 g. Validation tests conducted under these conditions yielded an average crystallization rate of 94.38% for the refined product. [Conclusions] The crystallization efficiency of ceftriaxone sodium is markedly enhanced, thereby offering substantial support for its industrial production and clinical application. 展开更多
关键词 Ceftriaxone sodium Response surface methodology(RSM) Crystallization process Process optimization
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Optimization of preparing V_2O_5 by calcination from ammonium metavanadate using response surface methodology 被引量:6
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作者 刘秉国 彭金辉 +3 位作者 万润东 张利波 郭胜惠 张世敏 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第3期673-678,共6页
Parameters of technique to prepare vanadium pentoxide by calcination from ammonium metavanadate were optimized using central composite design of response surface methodology. A quadratic equation model for decompositi... Parameters of technique to prepare vanadium pentoxide by calcination from ammonium metavanadate were optimized using central composite design of response surface methodology. A quadratic equation model for decomposition rate was built and effects of main factors and their corresponding relationships were obtained. The results of the statistical analysis show that the decomposition rate of ammonium metavanadate is significantly affected by calcination temperature and calcination time. The optimized calcination conditions are as follows: calcination temperature 669.71 K, calcination time 35.9 min and sample mass 4.25 g. The decomposition rate of ammonium metavanadate is 99.71%,which coincides well with experimental value of 99.27% under the optimized conditions, suggesting that regressive equation fits the decomposition rates perfectly. XRD reveals that it is feasible to prepare the V2O5 by calcination from ammonium metavanadate using response surface methodology. 展开更多
关键词 vanadium pentoxide ammonium metavanadate CALCINATION response surface methodology
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Identification of processing window for extrusion of large thick-walled Inconel 625 alloy pipes using response surface methodology 被引量:7
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作者 郭良刚 党利 +2 位作者 杨合 张君 郑文达 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2016年第7期1902-1911,共10页
Identifying suitable processing window is necessary but difficult for achieving favorable microstructure and performance in extrusion of large thick-walled pipe with difficult-to-deform Inconel 625 alloy. In this work... Identifying suitable processing window is necessary but difficult for achieving favorable microstructure and performance in extrusion of large thick-walled pipe with difficult-to-deform Inconel 625 alloy. In this work, a method was established for identifying the extrusion process window considering temperature control using response surface methodology. Firstly, the response surface models, which correlate temperature rise and peak temperature to key extrusion parameters, have been developed by orthogonal regression based on finite element calculated data. Secondly, the coupled effects of the key extrusion parameters on the temperature rise and peak temperature have been disclosed based on the regression models. Lastly, suitable extrusion processing windows, which are described by contour map of peak temperature in the space of extrusion speed and initial billet temperature, have been established for different extrusion ratios. Using the identified process window, a suitable combination of the key extrusion parameters can be determined conveniently and quickly. 展开更多
关键词 profile extrusion processing window response surface methodology difficult-to-deform materials finite element simulation
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Optimization and characterization of nimesulide bilayer tablets by response surface methodology 被引量:1
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作者 单利 范云周 +3 位作者 王玉丽 陈红鸽 高春生 杨美燕 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2014年第2期89-93,共5页
The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variab... The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer(FRL) and a sustained release layer(SRL) provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows:(I) the formulation of FRL: nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and(II) the formulation of SRL: nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets. 展开更多
关键词 NIMESULIDE Bilayer tablets Orthogonal design Central composite design-response surface methodology Sustainedrelease Fast release
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SCRAMJET INLET MULTI-OBJECTIVE OPTIMIZATION BASED ON RESPONSE SURFACE METHODOLOGY 被引量:1
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作者 李健 谷良贤 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2007年第3期205-210,共6页
The uniform design and response surface methodology (RSM) are applied to the multi-objective optimization of a 2-D mixed compression scramjet inlet. The set of experimental design points on the design space is selec... The uniform design and response surface methodology (RSM) are applied to the multi-objective optimization of a 2-D mixed compression scramjet inlet. The set of experimental design points on the design space is selected by the uniform design, and the inlet performance is analyzed by computational fluid dynamics (CFD). Then complete quadratic polynomial response surface approximation models are constructed based on the performance analysis results and then used to replace theoriginal complex inlet performance model. The optimization is conducted using a multi-objective genetic algorithm NSGA-Ⅱ, and the Pareto optimal solution set is obtained. Results show that the uniform design and RSM can reduce the computational complexity of numerical simulation and improve the optimization efficiency. 展开更多
关键词 scramjet inlet response surface methodology oblique shock multi-objective optimization
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Device Robust-Design by Using Response Surface Methodology
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作者 谢晓锋 鲁勇 +1 位作者 张文俊 杨之廉 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2002年第8期817-824,共8页
Device robust-design is inherently a multiple-objective optimization problem.Using design of experiments (DoE) combined with response surface methodology (RSM) can satisfy the great incentive to reduce the number of t... Device robust-design is inherently a multiple-objective optimization problem.Using design of experiments (DoE) combined with response surface methodology (RSM) can satisfy the great incentive to reduce the number of technology CAD(TCAD) simulations that need to be performed.However,the errors of RSM models might be large enough to diminish the validity of the results for some nonlinear problems.To find the feasible design space,a new method with objectives-oriented design in generations that takes the errors of RSM model into account is presented.After the augment design of experiments in promising space according to the results of RSM model in current generation,the feasible space will be emerging as the model errors deceasing.The results on FIBMOS examples show that the methodology is efficient. 展开更多
关键词 response surface methodology design of experiments device robust-design
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Optimization of the Fermentation Conditions of Sweet Oats by Response Surface Methodology
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作者 张泓 黄艳杰 +1 位作者 黄志兵 许杨 《Agricultural Science & Technology》 CAS 2014年第3期483-487,498,共6页
Objective] The purpose of this study was to evaluate the effects of five variables (steaming time, moisture content before inoculation, inoculation amount, fer-mentation temperature, fermentation time) on the sweetn... Objective] The purpose of this study was to evaluate the effects of five variables (steaming time, moisture content before inoculation, inoculation amount, fer-mentation temperature, fermentation time) on the sweetness of sweet oats, obtained the best fermentation conditions. [Method] Plackett-Burman (PB) was to evaluate the effects of five variables, and selected significant factors. The steepest ascent was used to approach the optimal response surface experimental area. The optimal fer-mentation condition was obtained by central composite design and response surface analysis. [Results] It was indicated that moisture content, inoculation amount and fer-mentation temperature had significant influences on the content of the reducing sugars. The optimal conditions of moisture content, inoculation amount and temper-ature were 45.26%, 0.014%(g/g) and 28 ℃, respectively. The predicted value of the reducing sugar content was 13.16 mg/g. [Conclusion] Under the optimal conditions, the content of the reducing sugars in the sweet oats could be up to 12.91 mg/g, which was on the whole consistent with the predictive maximum value. 展开更多
关键词 Sweet oats FERMENTATION Reducing sugars Response surface methodology
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Extraction Techniques of Krill Oils Optimized with Response Surface Methodology
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作者 李杰 李富威 +3 位作者 顾杨娟 俞所银 李越华 包建强 《Agricultural Science & Technology》 CAS 2014年第1期170-172,F0003,共4页
The research explored the extraction techniques of organic solvents of Antarctic kril oil and the effects of freezing temperature, extractant proportion, ex-traction time, drying temperature and ratio of material and ... The research explored the extraction techniques of organic solvents of Antarctic kril oil and the effects of freezing temperature, extractant proportion, ex-traction time, drying temperature and ratio of material and liquid on extraction ratio of Antarctic kril oil. Based on single-factor experiments, optimal extraction conditions were concluded as per response surface methodology, as fol ows: freezing tempera-ture at -38.5 ℃, the ratio of material and liquid at 1 g:6.7 ml, and drying tempera-ture at 66.8 ℃, where the yield rate of crude oil reached 13.71%. 展开更多
关键词 Response surface methodology Antarctic krill oil Extraction technology
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Optimization of Fermentation Conditions for Cellulase Production from Camellia Seed Shell Using Response Surface Methodology
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作者 杨俊换 郭华 欧阳晶 《Agricultural Science & Technology》 CAS 2015年第4期806-809,825,共5页
Objective] This study was conducted to optimize cameI ia seed sheI fer-mentation conditions for ceI uIase production by Trichoderma koningi using response surface methodoIogy. [Method] Fermentation conditions for ceI ... Objective] This study was conducted to optimize cameI ia seed sheI fer-mentation conditions for ceI uIase production by Trichoderma koningi using response surface methodoIogy. [Method] Fermentation conditions for ceI uIase production from Trichoderma koningi were optimized with response surface method (RSM) by taking carboxymethyI ceI uIase (CMCase) activity as a response indicator. Three factors that affecting CMCase activity were screened out using singIe factor test among pretreatment methods of raw material, nitrogen sources, initial pH values, inocuIum voIume, fermentation time and voIume of Iiquid medium, they were fermentation time, initial pH value, and voIume of Iiquid medium. The optimum conditions of fer-mentation and interaction of the three factors were determined through Box-Behnken design and regression analysis using Design-Expert software. [Result] Pretreatment of cameI ia seed sheI with alkaline was most conducive to CMCase production. The use of 0.2% (NH4)2SO4 as nitrogen source, inocuIum size of 5%, initial pH value of 5.8 and voIume of Iiquid medium at 22 mI were the best fermentation conditions for maximizing CMCase production by T. koningi from cameI ia seed sheI . Under these conditions, 179.15 U/mI of CMCase was obtalned after 5 d of fermentation, which was improved by 24.52% compared with the maximum CMCase activity of singIe factor test. [Conclusion] The resuIts wiI provide some references for use of cameI ia seed sheI and ceI uIase production. 展开更多
关键词 CameI la seed sheI Trichoderma koningi CarboxymethyI ceI ulase Re-sponse surface methodology
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Response surface methodology for optimizing adsorption performance of gel-type weak acid resin for Eu(Ⅲ) 被引量:1
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作者 陈婷 李斌 +3 位作者 方磊 陈德睢 许文斌 熊春华 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第12期4207-4215,共9页
The conditions relating to enhanced adsorption procedure of earth element europium(Eu) onto gel-type weak acid resin(110-H) in aqueous solution were optimized by means of the response surface methodology(RSM), w... The conditions relating to enhanced adsorption procedure of earth element europium(Eu) onto gel-type weak acid resin(110-H) in aqueous solution were optimized by means of the response surface methodology(RSM), which proved that 110-H owned satisfactory adsorption capacity(346.85 mg/g) in optimum conditions, belonging to one of the high adsorption capacity materials. Then, the adsorption and desorption behaviors were investigated by batch studies. The adsorption performance showed high agreement with the Lagergren-first-order model and Langmuir isotherm with thermodynamic adsorption parameters of ΔH= 36.1 k J/mol and ΔS=200 J/(mol·K). Desorption study revealed that 110-H could be effectively eluted by a low concentration of HCl solution(0.1 mol/L) to regenerate and reuse. Finally, the 110-H and Eu(III) loaded 110-H were characterized by IR spectroscopy and scanning electron microscope(SEM) to analyze the mechanism of adsorption, which proved to be chemisorbed. 展开更多
关键词 Eu(III) response surface methodology ADSORPTION gel-type weak acid resin
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Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology 被引量:48
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作者 Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin Ca 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2011年第1期22-30,共9页
Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degra... Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degradation (p 〈 0.05), as identified by a two-level Plackett-Burman design with 11 variables, were yeast extract, phenol, inoculum size, and temperature. Steepest ascent method was undertaken to determine the optimal regions of these four significant factors. Central composite design (CCD) and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation. The analysis results indicated that interactions between yeast extract and temperature, phenol and temperature, inocuhim size and temperature affected the response variable (phenol degradation) significantly. The predicted results showed that the maximum removal efficiency of phenol (99.10%) could be obtained under the optimum conditions of yeast extract 0.41 g/L, phenol 1.03 g/L, inoculum size 1.43% (V/V) and temperature 30.04℃. These predicted values were further verified by validation experiments. The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy. This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents. 展开更多
关键词 phenol degradation Candida tropicalis Z-04 OPTIMIZATION Plackett-Burman design response surface methodology
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Effects of AlN hydrolysis on fractal geometry characteristics of residue from secondary aluminium dross using response surface methodology 被引量:15
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作者 Yong ZHANG Zhao-hui GUO +1 位作者 Zi-yu HAN Xi-yuan XIAO 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第12期2574-2581,共8页
The effects of aluminium nitride(AlN)hydrolysis on fractal geometry characteristics of residue from secondary aluminium dross were studied using response surface methodology.The results show that the fractal dimension... The effects of aluminium nitride(AlN)hydrolysis on fractal geometry characteristics of residue from secondary aluminium dross were studied using response surface methodology.The results show that the fractal dimensions of the residue can be significantly influenced by the AlN hydrolysis from secondary aluminium dross.The hydrolysis of AlN in the dross was spontaneous under temperatures of303-373K.The actual fractal dimensions of residue were significantly affected by the liquid-solid ratio(p<0.05)and changed from1.16to1.80,which accurately aligned with those from the calculations.Moreover,the fractal dimensions of residue were significantly affected by the interactions between hydrolysis temperature and hydrolysis time,liquid-solid ratio and hydrolysis time,respectively(p<0.01).The minimum fractal dimensions of the residue reached1.15under the optimized conditions,which included a hydrolysis temperature of30℃,liquid-solid ratio of5mL/g and hydrolysis time of10min.The results suggest that response surface methodology can guide in optimizing the conditions of AlN hydrolysis in order to obtain the minimum fractal dimensions of residue for improving the reutilization of the dross. 展开更多
关键词 secondary aluminium dross AlN hydrolysis fractal dimensions optimization response surface methodology
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