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Research on Mild and Effective Sunscreen Synergistic Ingredients
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作者 Ye Xiulin Wu Bizhi +6 位作者 Huang Min Luo Shaoqiang Liu Jinghua Li Qiuxi Zeng Yunyun Huang Runmei Zhou Wei 《China Detergent & Cosmetics》 2026年第1期61-65,共5页
The UV-2600 ultraviolet(UV)spectrophotometer and the UV sunscreen index analyzer SolarLight Model 601 were used to test the UV absorption capacity and the UV damage alleviating effect of commonly used raw materials,an... The UV-2600 ultraviolet(UV)spectrophotometer and the UV sunscreen index analyzer SolarLight Model 601 were used to test the UV absorption capacity and the UV damage alleviating effect of commonly used raw materials,and the Hen’s Egg Test-Chorioallantoic Membrane were also processed to assess the mildness.As a result,bisabolol,pongamia pinnata seed extract,pterocarpus marsupium bark extract and other materials were screened as the effective and gentle sunscreen synergistic ingredients. 展开更多
关键词 ultraviolet damage sun protection synergistic effect
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血清CITED2、BMAL1、NSUN3水平与脓毒症并发急性肾损伤患者病情的相关性及对预后的影响
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作者 陈曼宁 李璐 +3 位作者 刘睿 黎璞 彭细娟 高雅 《疑难病杂志》 2026年第3期291-297,共7页
目的分析血清富含ED尾的CBP/p300相互作用反式激活因子2(CITED2)、脑-肌肉芳烃受体核转录因子样蛋白-1(BMAL1)、NOP2/Sun RNA甲基转移酶3(NSUN3)水平与脓毒症并发急性肾损伤(AKI)患者病情的相关性及对预后不良的影响。方法选取2023年2月... 目的分析血清富含ED尾的CBP/p300相互作用反式激活因子2(CITED2)、脑-肌肉芳烃受体核转录因子样蛋白-1(BMAL1)、NOP2/Sun RNA甲基转移酶3(NSUN3)水平与脓毒症并发急性肾损伤(AKI)患者病情的相关性及对预后不良的影响。方法选取2023年2月—2025年3月空军军医大学唐都医院重症医学科收治的脓毒症并发AKI患者123例作为脓毒症AKI组,脓毒症并发AKI患者根据AKI分期标准分为Ⅰ期45例、Ⅱ期40例、Ⅲ期38例,根据治疗28 d的生存情况分为生存亚组81例与死亡亚组42例,另选取同期医院收治的单纯脓毒症患者115例作为脓毒症组、健康志愿者123例作为健康对照组。采用ELISA法检测血清CITED2水平,qRT-PCR法检测血清BMAL1、NSUN3 mRNA表达;Pearson相关性分析变量间关系;多因素Cox分析影响脓毒症并发AKI患者预后不良的因素;受试者工作特征(ROC)曲线分析脓毒症并发AKI患者预后不良的预测价值。结果健康对照组、脓毒症组、脓毒症AKI组血清CITED2、NSUN3 mRNA水平依次升高,血清BMAL1 mRNA水平依次降低(F/P=544.535/<0.001、728.950/<0.001、478.098/<0.001);Ⅰ期、Ⅱ期、Ⅲ期脓毒症AKI患者血清CITED2、NSUN3 mRNA水平依次升高,血清BMAL1 mRNA水平依次降低(F/P=33.532/<0.001、22.012/<0.001、72.544/<0.001);死亡亚组血清CITED2、NSUN3 mRNA高于生存亚组,血清BMAL1 mRNA水平低于生存亚组(t/P=7.514/<0.001、7.639/<0.001、8.095/<0.001);脓毒症AKI患者血清CITED2、NSUN3 mRNA分别与APACHEⅡ评分、SOFA评分呈正相关(CITED2:r/P=0.512/<0.001、0.508/<0.001;NSUN3 mRNA:0.506/<0.001、0.513/<0.001),血清BMAL1 mRNA与APACHEⅡ评分、SOFA评分呈负相关(r/P=-0.527/<0.001、-0.519/<0.001);APACHEⅡ评分高、SOFA评分高、CITED2高、NSUN3 mRNA高是脓毒症AKI患者预后不良的独立危险因素[HR(95%CI)=2.078(1.353~3.192)、2.343(1.458~3.765)、2.436(1.763~3.366)、2.651(1.777~3.954)],BMAL1 mRNA高是独立保护因素[HR(95%CI)=0.314(0.172~0.572)];血清CITED2、BMAL1 mRNA、NSUN3 mRNA单独及三者联合预测脓毒症AKI患者预后不良的曲线下面积(AUC)分别为0.794、0.814、0.810、0.916,三者联合优于各自单独预测价值(Z/P=2.780/0.005、2.084/0.037、2.435/0.015)。结论脓毒症并发AKI患者血清CITED2、NSUN3 mRNA水平升高,BMAL1 mRNA水平下降,三者与病情程度、预后不良有关,可作为潜在的脓毒症并发AKI患者28 d内死亡的生物指标。 展开更多
关键词 脓毒症 急性肾损伤 富含ED尾的CBP/p300相互作用反式激活因子2 脑-肌肉芳烃受体核转录因子样蛋白-1 NOP2/sun RNA甲基转移酶3 病情程度 预后
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System modeling based measurement error analysis of digital sun sensors 被引量:7
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作者 WEI M insong XING Fei +1 位作者 WANG Geng YOU Zheng 《Instrumentation》 2015年第1期27-32,共6页
Stringent attitude determination accuracy is required for the development of the advanced space technologies and thus the accuracy improvement of digital sun sensors is necessary.In this paper,we presented a proposal ... Stringent attitude determination accuracy is required for the development of the advanced space technologies and thus the accuracy improvement of digital sun sensors is necessary.In this paper,we presented a proposal for measurement error analysis of a digital sun sensor.A system modeling including three different error sources was built and employed for system error analysis.Numerical simulations were also conducted to study the measurement error introduced by different sources of error.Based on our model and study,the system errors from different error sources are coupled and the system calibration should be elaborately designed to realize a digital sun sensor with extra-high accuracy. 展开更多
关键词 DIGITAL sun SENSORS MEASUREMENT ERROR system modeling NUMERICAL simulation
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NSUN2通过介导ARMC9的m5C修饰促进胃癌细胞的增殖、转移和侵袭
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作者 李越 陈栋 +4 位作者 王瑾 彭怡 张远琦 杨芬 王学军 《中国药科大学学报》 北大核心 2025年第5期583-591,共9页
为研究NOP2/Sun RNA甲基转移酶2(NOP2/Sun RNA methyltransferase 2,NSUN2)对胃癌恶性进展的影响及其潜在机制,使用TCGA数据库分析发现胃癌组织中NSUN2表达水平显著升高;Western blot发现,与胃黏膜上皮细胞相比,NSUN2在胃癌细胞中表达上... 为研究NOP2/Sun RNA甲基转移酶2(NOP2/Sun RNA methyltransferase 2,NSUN2)对胃癌恶性进展的影响及其潜在机制,使用TCGA数据库分析发现胃癌组织中NSUN2表达水平显著升高;Western blot发现,与胃黏膜上皮细胞相比,NSUN2在胃癌细胞中表达上调;集落形成实验显示,NSUN2过表达细胞中集落形成能力增高;Transwell实验也证实NSUN2高表达时,发生迁移和侵袭的细胞数量显著增多。进一步通过数据库分析推测ARMC可能是NSUN2的下游靶分子,接着通过MeRIP-qPCR揭示NSUN2高表达可以提高ARMC9的m5C修饰水平,并且降低ARMC9 mRNA的降解速率,从而提高其蛋白表达水平。此外,过表达ARMC9可以增强细胞的集落形成能力和迁移侵袭能力。上述结果显示,NSUN2可以通过提高ARMC9 mRNA的m5C修饰水平,提高其稳定性,增强其表达,从而促进胃癌进展,因此NSUN2和ARMC9可以作为胃癌进展的潜在治疗靶标。 展开更多
关键词 5-甲基胞嘧啶 甲基转移酶 NOP2/sun RNA甲基转移酶2 犰狳重复序列9 胃癌 肿瘤标志物
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科利登Sapphire S测试系统被Sun Microsystems公司采用
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《半导体技术》 CAS CSCD 北大核心 2006年第7期556-556,共1页
科利登系统有限公司近日宣布:Sun Microsys tems公司购买了配置D-6436的Sapphire^TMS自动测试设备。D-6436是一款高性能高通道密度的功能测试设备,它主要用于调试和测试超过6.4Gbps的高速芯片。Sun公司将把该系统使用于其下一代基于S... 科利登系统有限公司近日宣布:Sun Microsys tems公司购买了配置D-6436的Sapphire^TMS自动测试设备。D-6436是一款高性能高通道密度的功能测试设备,它主要用于调试和测试超过6.4Gbps的高速芯片。Sun公司将把该系统使用于其下一代基于SPARC的多线程微处理器芯片的开发。 展开更多
关键词 systems公司 sun公司 测试系统 自动测试设备 微处理器芯片 SPARC 高速芯片 系统使用
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SUN2调控稳定表达绵羊肺腺瘤病毒囊膜蛋白的OAR-L1细胞的恶性转化能力的研究
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作者 鲍安玉 杜晓悦 +3 位作者 陈思旭 段续接 张培 刘淑英 《中国兽医科学》 北大核心 2025年第5期669-677,共9页
为了探究SAD1/UN84结构域蛋白-2(SAD1/UNC84 domain protein-2,SUN2)在绵羊肺腺瘤病(ovine pulmonary adenocarcnoma,OPA)肿瘤细胞恶性转化中的功能,本试验利用实验室保存的JSRV env慢病毒感染绵羊肺成纤维细胞(OAR-L1),建立了OAR-L1-En... 为了探究SAD1/UN84结构域蛋白-2(SAD1/UNC84 domain protein-2,SUN2)在绵羊肺腺瘤病(ovine pulmonary adenocarcnoma,OPA)肿瘤细胞恶性转化中的功能,本试验利用实验室保存的JSRV env慢病毒感染绵羊肺成纤维细胞(OAR-L1),建立了OAR-L1-Env稳转株。通过qPCR和Western-blot检测JSRV Env和SUN2的表达情况,使用CCK-8、划分愈合试验和软琼脂糖集落形成试验检测细胞的恶性转化能力。此外,分别构建SUN2过表达和干扰质粒,并转染OAR-L1-Env稳转株,利用qPCR和Western-blot检测其SUN2的表达情况,通过CCK-8和划分愈合试验检测细胞的增殖和迁移能力。结果显示,OAR-L1-Env稳转株成功建立,且SUN2表达量显著下调(P<0.05),CCK-8、划分愈合试验和软琼脂糖集落形成试验表明OAR-L1-Env稳转株发生恶性转化。OAR-L1-Env稳转株中过表达SUN2可抑制细胞的增殖和迁移能力(P<0.05),而干扰SUN2则促进细胞的增殖和迁移能力(P<0.05)。综上所述,本研究表明SUN2参与调控JSRV Env诱导的细胞恶性转化,提示其可能对OPA肿瘤生成有抑制作用。本研究为进一步探究SUN2在OPA中的细胞增殖等生物学作用的研究提供了一定的参考资料。 展开更多
关键词 稳转株 囊膜蛋白 sun2 增殖 迁移
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Correlations between the Rotations and Magnetospheres of the Terrestrial Planets and the Sun’s Formation in Our Solar System
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作者 Fred J. Cadieu 《World Journal of Condensed Matter Physics》 CAS 2022年第2期18-26,共9页
Correlations between the rotations of the terrestrial planets in our solar system and the magnetic field of the Sun have been previously noted. These correlations account for the opposite rotation of Venus as a result... Correlations between the rotations of the terrestrial planets in our solar system and the magnetic field of the Sun have been previously noted. These correlations account for the opposite rotation of Venus as a result of the magnetic field of the Sun being dragged across the conducting core of Venus. Currently, the Sun’s magnetic field is not sufficiently strong to account for the proposed correlations. But recently meteorite paleomagnetism measurements have indicated that during the Sun’s formation the magnetic field of the Sun was of sufficient strength to have resulted in the observed correlations. Also, dating back to the Sun’s formation are measurements showing that the Sun’s core rotates four times faster than the Sun’s surface. Both the counter rotation of Venus and the initial period of strong Sun magnetic fields are believed to be relics of the time period when the Sun’s core to surface differential rotation was established. As a part of these correlations, it was hypothesized that for a terrestrial planet to exhibit a magnetosphere, the average density must be ≥5350 ± 50 kg/m<sup>3</sup>. On this basis, only the Earth and Mercury would have formed initial magnetospheres, while Venus, Mars, and the “Moon” would not have developed magnetospheres. For such correlations to still be present today requires our Sun to have been formed as a sole star and with what might be termed a friendly Jupiter. Otherwise, the observed correlations would have been disrupted over time. 展开更多
关键词 Earth MERCURY VENUS MARS Magnetic Fields sun Early Solar system Plate Tectonics
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A Sun Tracking System Design for a Large Dish Solar Concentrator
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作者 Xiaoshan Jin Guoqiang Xu +2 位作者 Rongjiu Zhou Xiang Luo Yongkai Quan 《International Journal of Clean Coal and Energy》 2013年第2期16-20,共5页
Energy crisis promotes the development of renewable energy, especially the solar energy. Sun tracking system proposed in this paper is such a device for efficiency improvement. This closed loop tracking system with tw... Energy crisis promotes the development of renewable energy, especially the solar energy. Sun tracking system proposed in this paper is such a device for efficiency improvement. This closed loop tracking system with two axis sun tracking method is controlled by a programmable logic controller (PLC) and is used for a large dish solar collector. A combination tracking mode combined active and passive tracking methods used in the design make the tracker efficient whatever the circumstances. Two stepper motors and two reduction boxes move the device towards the sun with chain transmission. Besides sun tracking, the system also has functions of overheat monitoring, wind speed monitoring and measurement of illumination. 展开更多
关键词 RENEWABLE ENERGY Solar ENERGY sun TRACKING PLC COMBINATION TRACKING Mode
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Hi-tech Logistic System Innovates Time-honored Tea Brand An interview with Sun Yingbin, logistics manager of Wuyutai
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作者 Jiang Zhijun 《China & The World Cultural Exchange》 2014年第11期38-39,共2页
The 40-acre factory compound, huge storehouses, modern production and distribution lines, and hard-working staff members, all these impressed me so much when I took an interview event with Sun Yingbin, logistics manag... The 40-acre factory compound, huge storehouses, modern production and distribution lines, and hard-working staff members, all these impressed me so much when I took an interview event with Sun Yingbin, logistics manager of century-old tea brand Wuyutai, in its logistics and distribution center in the suburb of Beijing. 展开更多
关键词 物流体系 sun 品牌 茶叶 经理 字号 创新 工作人员
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Design of low-energy transfer from lunar orbit to asteroid in the Sun-Earth-Moon system
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作者 Ya-Min Wang Dong Qiao Ping-Yuan Cui 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2014年第6期966-972,共7页
Asteroid exploration trajectories which start from a lunar orbit are investigated in this work.It is assumed that the probe departs from lunar orbit and returns to the vicinity of Earth,then escapes from the Earth by ... Asteroid exploration trajectories which start from a lunar orbit are investigated in this work.It is assumed that the probe departs from lunar orbit and returns to the vicinity of Earth,then escapes from the Earth by performing a perigee maneuver.A low-energy transfer in Sun-EarthMoon system is adopted.First,the feasible region of lowenergy transfer from lunar orbit to perigee within 5 000 km height above the Earth surface in Sun-Earth-Moon system is calculated and analyzed.Three transfer types are found,i.e.,large maneuver and fast transfers,small maneuver and fast transfers,and disordered and slow transfers.Most of feasibility trajectories belong to the first two types.Then,the lowenergy trajectory leg from lunar orbit to perigee and a heliocentric trajectory leg from perigee to asteroid are patched by a perigee maneuver.The optimal full-transfer trajectory is obtained by exploiting the differential evolution algorithm.Finally,taking 4179 Toutatis asteroid as the target,some low-energy transfer trajectories are obtained and analyzed. 展开更多
关键词 Lunar orbit Asteroid exploration Low-energy transfer sun-Earth-Moon system
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Sun Zhigang's Death and Reform of Detention System
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作者 YUN XIANG 《The Journal of Human Rights》 2003年第5期19-26,共8页
The Measures on Aid and Management for Urban Vagrants and Beggars, issued by the State Council in mid-July, took effect on August 1. It marks a further improvement of China’s mechanism to aid urban vagrants and begga... The Measures on Aid and Management for Urban Vagrants and Beggars, issued by the State Council in mid-July, took effect on August 1. It marks a further improvement of China’s mechanism to aid urban vagrants and beggars. The new regulation has been enacted to replace the two-decade-old Measures for the Internment and Deportation of Urban Vagrants and Beggars. This policy reform has stemmed from the astounding case of Sun Zhigang, a young man that was brutally beaten to death while in custody at the Guangzhou Detention Center. 展开更多
关键词 of on or it as that sun Zhigang’s Death and Reform of Detention system been FORM into
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Procom与Sun Microsystems签署多年技术协议
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《电子与电脑》 2004年第5期144-144,共1页
关键词 Procom公司 sun Microsystems公司 技术协议 OEM
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宫颈癌组织NSUN6、SULF1表达与临床病理特征关系及预后价值 被引量:1
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作者 张毅 伍紫蕊 +1 位作者 李玉佳 黄官友 《疑难病杂志》 2025年第7期843-847,854,共6页
目的 研究宫颈癌组织NOP2/Sun RNA甲基转移酶家族成员6(NSUN6)、硫酸酯酶1(SULF1)的表达及其与临床病理特征和预后的关系。方法 选取2019年6月—2021年6月贵州医科大学附属医院妇产科收治的宫颈癌患者92例的临床资料。利用实时荧光定量... 目的 研究宫颈癌组织NOP2/Sun RNA甲基转移酶家族成员6(NSUN6)、硫酸酯酶1(SULF1)的表达及其与临床病理特征和预后的关系。方法 选取2019年6月—2021年6月贵州医科大学附属医院妇产科收治的宫颈癌患者92例的临床资料。利用实时荧光定量PCR和免疫组织化学检测癌组织NSUN6、SULF1 mRNA和蛋白表达;应用R语言分析人类基因组图谱(TCGA)数据库中宫颈癌组织和正常宫颈组织中NSUN6、SULF1表达差异;K-M曲线分析NSUN6、SULF1蛋白表达对宫颈癌患者预后的影响;Cox回归模型筛选宫颈癌预后的影响因素。结果 TCGA数据库分析结果显示,宫颈癌组织中NSUN6、SULF1 mRNA表达高于正常宫颈组织(t/P=22.281/<0.001、53.721/<0.001);宫颈癌患者癌组织NSUN6、SULF1 mRNA表达均高于癌旁组织(t/P=37.619/<0.001、36.442/<0.001),宫颈癌组织NSUN6、SULF1蛋白阳性率均高于癌旁组织(χ^(2)/P=85.546/<0.001、86.891/<0.001);宫颈癌组织NSUN6、SULF1蛋白阳性率在FIGO分期ⅠB2~ⅡB期、淋巴结转移均高于ⅠA~ⅠB1期、无淋巴结转移(t/P=7.934/0.005、5.327/0.021、13.512/<0.001、4.564/0.033);NSUN6阳性与阴性、SULF1阳性与阴性3年总生存(OS)率之间比较,差异均无统计学意义(P>0.05),NSUN6阳性、SULF1阳性患者3年无进展生存(PFS)率均低于阴性患者(χ^(2)/P=8.120/0.004、36.442/<0.001);FIGO分期ⅠB2~ⅡB期、淋巴结转移、NSUN6阳性、SULF1阳性是宫颈癌患者预后不良的危险因素[HR(95%CI)=1.402(1.115~1.764)、1.339(1.094~1.639)、1.374(1.082~1.746)、1.278(1.054~1.548)]。结论 宫颈癌组织中NSUN6、SULF1 mRNA和蛋白表达均升高,两者均与不良临床病理特征相关,是评估宫颈癌预后的标志物。 展开更多
关键词 宫颈癌 NOP2/sun RNA甲基转移酶家族成员6 硫酸酯酶1 预后
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Sun Microsystems在中国
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作者 吴新瞻 《今日电子》 1998年第1期5-6,共2页
值此新的九八年来临之际,谨向《今日电子》经常的、偶然的,以及未来的读者致以真诚的问候和祝福! 《今日电子》还不是一本广为人知的刊物。去年十月底我去长沙国防科大参加分布与并行计算会议,与会代表竟然极少有人见过它。当他们读到... 值此新的九八年来临之际,谨向《今日电子》经常的、偶然的,以及未来的读者致以真诚的问候和祝福! 《今日电子》还不是一本广为人知的刊物。去年十月底我去长沙国防科大参加分布与并行计算会议,与会代表竟然极少有人见过它。当他们读到我寄去的杂志后,认为《今日电子》内容丰富,很值得高等院校师生和科研人员阅读,建议我们应该多做些宣传工作。北京一些经常阅读本刊的读者也表示此刊值得保存,并非看过后即随手放置的那一类。 展开更多
关键词 sun公司 信息技术 国际互联网 中国
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连智浩 Sun Microsystems大中华区总裁
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《通讯世界》 2008年第3期17-17,共1页
近日,Sun Microsystems公司宣布,任命连智浩(Chi-Ho Christopher Lin)先生为Sun公司大中华区新任总裁,负责Sun公司大中华区(包含中国大陆、香港以及台湾地区)所有业务并管理与重要客户和业务伙伴的合作关系。
关键词 sun公司 中华 总裁 systems公司 MICRO 中国大陆 合作关系 台湾地区
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Sun Microsystems选择Emulex为Sun Blade系列服务器提供新的ExpressModule主机总线适配器
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《计算机与网络》 2009年第22期57-57,共1页
Emulex Corporation近日宣布推出集8Gb/S光纤通道和IGb/S以太网于一体的ExpressModule主机总线适配器(HBA)。ExpressModule HBA主要面向Sun Blade6000模块化系统,可以为虚拟化服务器、大型或混合型存储区域网络(SAN)以及本地区... Emulex Corporation近日宣布推出集8Gb/S光纤通道和IGb/S以太网于一体的ExpressModule主机总线适配器(HBA)。ExpressModule HBA主要面向Sun Blade6000模块化系统,可以为虚拟化服务器、大型或混合型存储区域网络(SAN)以及本地区域网络(LAN)环境提供更高的性能、出色的灵活性以及更高的插槽利用率。 展开更多
关键词 总线适配器 sun 服务器 主机 GB/S以太网 存储区域网络 模块化系统 光纤通道
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视网膜母细胞瘤组织中NSUN2 mRNA,PRMT5 mRNA表达水平与临床病理学特征及预后的相关性研究
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作者 万宇 邹云春 +3 位作者 王岚 李娜 何艺岚 王淑 《现代检验医学杂志》 2025年第4期61-66,共6页
目的探讨视网膜母细胞瘤(Rb)组织中NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)、蛋白精氨酸甲基转移酶5(PRMT5)表达水平及与Rb患者生存预后的相关性。方法选取2019年2月~2021年2月首都医科大学附属北京安贞医院南充医院诊治的84例Rb患者(R... 目的探讨视网膜母细胞瘤(Rb)组织中NOP2/Sun RNA甲基转移酶家族成员2(NSUN2)、蛋白精氨酸甲基转移酶5(PRMT5)表达水平及与Rb患者生存预后的相关性。方法选取2019年2月~2021年2月首都医科大学附属北京安贞医院南充医院诊治的84例Rb患者(Rb组),以50例正常视网膜组织为对照组。采用实时荧光定量PCR(qRT-PCR)检测视网膜组织中NSUN2 mRNA,PRMT5 mRNA表达水平。Kaplan-Meier曲线分析NSUN2 mRNA,PRMT5 mRNA对Rb患者预后的影响。COX回归分析影响Rb预后的因素。结果Rb癌组织NSUN2 mRNA(3.11±0.42),PRMT5 mRNA(2.84±0.39)表达高于对照组(0.80±0.23,0.76±0.20),差异具有统计学意义(t=35.935,35.033,均P<0.001)。肿瘤直径≥20mm,未分化型及IIRC分期D~E期Rb癌组织NSUN2 mRNA,PRMT5 mRNA表达高于肿瘤直径<20mm,分化型组织及IIRC分期A~C期,差异具有统计学意义(t=18.297,141.770,16.693;18.663,139.144,39.947,均P<0.001)。NSUN2 mRNA高表达组三年无进展生存率低于低表达组(60.00%vs 88.64%),PRMT5 mRNA高表达组三年无进展生存率低于低表达组(56.10%vs 93.02%),差异具有统计学意义(Log rankχ^(2)=13.440,19.501,均P<0.001)。未分化型、IIRC分期D~E期、NSUN2 mRNA高表达、PRMT5 mRNA高表达是影响Rb患者预后的危险因素(Waldχ^(2)=5.923~7.161,均P<0.001)。结论Rb组织中NSUN2 mRNA,PRMT5 mRNA表达升高,与肿瘤最大径、病理分型及IIRC分期有关,可作为评估Rb生存预后的肿瘤标志物。 展开更多
关键词 视网膜母细胞瘤 NOP2/sun RNA甲基转移酶家族成员2 蛋白精氨酸甲基转移酶5
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RNA甲基转移酶NSUN2通过介导TEAD1 m5C甲基化修饰促进胃癌细胞的糖酵解作用
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作者 王春云 阳乐斌 唐芬芬 《华中科技大学学报(医学版)》 北大核心 2025年第6期812-820,883,共10页
目的 探讨NOP2/Sun RNA甲基转移酶2(NSUN2)通过介导TEA结构域转录因子1(TEAD1)5-甲基胞嘧啶(m5C)甲基化修饰对胃癌(gastric cancer, GC)细胞糖酵解的影响及其机制。方法 实时荧光定量PCR(qRT-PCR)检测人胃癌(GC)组织中NSUN2和TEAD1 mRN... 目的 探讨NOP2/Sun RNA甲基转移酶2(NSUN2)通过介导TEA结构域转录因子1(TEAD1)5-甲基胞嘧啶(m5C)甲基化修饰对胃癌(gastric cancer, GC)细胞糖酵解的影响及其机制。方法 实时荧光定量PCR(qRT-PCR)检测人胃癌(GC)组织中NSUN2和TEAD1 mRNA表达水平,Pearson相关分析两者相关性。qRT-PCR和蛋白质印迹法(Western blot)检测人正常胃黏膜上皮细胞GES-1及胃癌AGS、HGC-27、SNU-1和MKN-45等细胞系中NSUN2表达水平。将NSUN2干扰慢病毒(sh-NSUN2)及其阴性对照sh-NC、TEAD1过表达质粒(oe-TEAD1)及其阴性对照(Vector)分别或同时转染至HGC-27细胞中,CCK-8检测细胞增殖活性。葡萄糖摄取、乳酸含量以及三磷酸腺苷(ATP)检测试剂盒评估细胞糖酵解。Western blot检测细胞中糖酵解途径相关蛋白(HK2、LDHA、GLUT1)表达水平。qRT-PCR和Western blot检测细胞中TEAD1 mRNA和蛋白表达水平。RNA测序(RNA-seq)和RNA甲基化免疫共沉淀实验筛选NSUN2的5-甲基胞嘧啶(m5C)修饰靶点,同时采用斑点杂交和双荧光素酶报告基因实验验证其调控功能。结果 与癌旁组织比较,GC组织中NSUN2和TEAD1 mRNA表达水平均显著升高(均P<0.05),且两者呈正相关(r=0.3266,P<0.05)。与GES-1细胞系比较,胃癌细胞系(AGS、HGC-27、SNU-1和MKN-45)中NSUN2 mRNA和蛋白表达水平显著升高,其中在HGC-27细胞系中表达最高(均P<0.05)。沉默NSUN2可显著降低HGC-27细胞增殖活性和糖酵解,下调HK2、LDHA和GLUT1蛋白表达水平,同时细胞中TEAD1 mRNA和蛋白表达水平显著降低(均P<0.05)。TEAD1是NSUN2调控的潜在靶点,沉默NSUN2通过m5C修饰的方式降低TEAD1的表达(P<0.05)。然而,过表达TEAD1可明显逆转沉默NSUN2对HGC-27细胞增殖活性和糖酵解的抑制作用。结论 NSUN2通过m5C依赖性的方式增强TEAD1的表达进而促进GC细胞的糖酵解。 展开更多
关键词 NOP2/sun RNA甲基转移酶2 TEA结构域转录因子1 5-甲基胞嘧啶 甲基化 胃癌 糖酵解
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Observations of Wave Amplitude Modulation in and Around Sunspots by SDO
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作者 A.Abedini 《Research in Astronomy and Astrophysics》 2025年第12期20-33,共14页
This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magn... This study analyzes the evolution and dynamics of intensity oscillations in coronal sunspots and their surroundings using multi-wavelength image data from the Atmospheric Imaging Assembly(AIA)and Helioseismic and Magnetic Imager(HMI)on board the Solar Dynamics Observatory(SDO).Intensity time series were extracted and analyzed from consecutive macropixels along thin coronal loop paths originating in a quiet sunspot.Fourier and wavelet analyses of corrected intensity time series reveal dominant 3 and 5 minute oscillations.Signals were filtered using the Fourier and inverse transforms to isolate narrow bands around the dominant oscillation periods.Diagrams and time-distance maps of intensity time series were plotted for Fourierfiltered AIA 131A,171A,193A,and 211A channels,along with SDO/HMI magnetograms and dopplergrams at 6173A.The plots clearly show propagating oscillations with amplitude modulation(AM)across all macropixels along selected coronal paths in nearly all AIA and HMI channels.The phase speeds of the filtered oscillations,measured via slope calculations in time-distance maps,indicate that the intensity disturbances are slow magneto-acoustic waves.These results suggest that AM likely arises from the superposition of counterpropagating waves with slightly different frequencies(beta-like phenomena)due to Doppler shifts from background plasma flow along loop paths.Validating this hypothesis could establish AM's significance in solar coronal seismology for determining background plasma flow speed,the source of long-period oscillations,and coronal plasma heating mechanisms. 展开更多
关键词 The sun sun:corona (sun:)sunspots sun:oscillations
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Evolution of Periodic Orbits in the Sun-Saturn System
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作者 Niraj Pathak R. K. Sharma V. O. Thomas 《International Journal of Astronomy and Astrophysics》 2016年第2期175-197,共23页
We analyze the periodic orbits, quasi periodic orbits and chaotic orbits in the photo gravitational Sun-Saturn system incorporating actual oblateness of Saturn in the planar circular restricted three body problem. In ... We analyze the periodic orbits, quasi periodic orbits and chaotic orbits in the photo gravitational Sun-Saturn system incorporating actual oblateness of Saturn in the planar circular restricted three body problem. In this paper, we study the effect of solar radiation pressure on the location of Sun centered and Saturn centered orbits, its diameter, semi major axis and eccentricity by taking different values of solar radiation pressure q and different values of Jacobi constant “C”, and by considering actual oblateness of Saturn using Poincare surface of section (PSS) method. It is ob-served that by the introduction of perturbing force due to solar radiation pressure admissible range of Jacobi constant C decreases, it is also observed that as value of C decreases the number of islands decreases and as a result the number of periodic and quasi periodic orbits decreases.Fur-ther, the periodic orbits around Saturn and Sun moves towards Sun by decreasing perturbation due to solar radiation pressure q for a specific choice of Jacobi constant C. It is also observed that due to solar radiation pressure, semi major axis and eccentricity of Sun centered periodic orbit reduces, whereas, due to solar radiation pressure uniform change in semi major axis and eccen-tricity of Saturn centered periodic orbits is observed. 展开更多
关键词 Restricted Three Body Problem sun-Saturn system Periodic Orbits Quasi Periodic Orbits Chaotic Orbits Photo Gravitation OBLATENESS Poincare Surface Section
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