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Stepwise Method Based on Confidence Bound and Information Incorporation for Identifying the Maximum Tolerable Dose
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作者 王雪丽 陶剑 史宁中 《Northeastern Mathematical Journal》 CSCD 2005年第1期117-126,共10页
The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine t... The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method. 展开更多
关键词 confidence bound continual reassessment method information incorporation maximum tolerable dose phase I clinical trials stepwise method
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Stepwise inversion method using second-order derivatives of elastic impedance for fracture detection in orthorhombic medium
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作者 Wei Xiang Xing-Yao Yin +2 位作者 Kun Li Zheng-Qian Ma Ya-Ming Yang 《Petroleum Science》 2025年第8期3229-3246,共18页
Reservoirs with a group of vertical fractures in a vertical transversely isotropic(VTI)background are considered as orthorhombic(ORT)medium.However,fracture detection in ORT medium using seismic inversion methods rema... Reservoirs with a group of vertical fractures in a vertical transversely isotropic(VTI)background are considered as orthorhombic(ORT)medium.However,fracture detection in ORT medium using seismic inversion methods remains challenging,as it requires the estimation of more than eight parameters.Assuming the reservoir to be a weakly anisotropic ORT medium with small contrasts in the background elastic parameters,a new azimuthal elastic impedance equation was first derived using parameter combinations and mathematical approximations.This equation exhibited almost the same accuracy as the original equation and contained only six model parameters:the compression modulus,anisotropic shear modulus,anisotropic compression modulus,density,normal fracture weakness,and tangential fracture weakness.Subsequently,a stepwise inversion method using second-order derivatives of the elastic impedance was developed to estimate these parameters.Moreover,the Thomsen anisotropy parameter,epsilon,was estimated from the inversion results using the ratio of the anisotropic compression modulus to the compression modulus.Synthetic examples with moderate noise and field data examples confirm the feasibility and effectiveness of the inversion method.The proposed method exhibited accuracy similar to that of previous inversion strategies and could predict richer vertical fracture information.Ultimately,the method was applied to a three-dimensional work area,and the predictions were consistent with logging and geological a priori information,confirming the effectiveness of this method.Summarily,the proposed stepwise inversion method can alleviate the uncertainty of multi-parameter inversion in ORT medium,thereby improving the reliability of fracture detection. 展开更多
关键词 Orthorhombic medium Fracture detection stepwise inversion method Azimuthal elastic impedance Thomsen anisotropy parameter
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Investigation on flight load calibration of aircraft composite wing base on strain gauge measurement
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作者 Xiajun Zhao Yazhi Li +1 位作者 Zhaoxin Yun Wei Zhang 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第5期335-345,共11页
A computational and test method for calibrating the flight loads carried by aircraft wings is proposed.The wing load is measured in real-time based on the resistance and fiber Bragg grating strain gauges.The linear st... A computational and test method for calibrating the flight loads carried by aircraft wings is proposed.The wing load is measured in real-time based on the resistance and fiber Bragg grating strain gauges.The linear stepwise regression method is used to construct the load equations.The mean impact value algorithm is employed to select suitable bridges.In the ground calibration experiment,the wing load calculation equations in both forward and reverse installation states are calibrated.The correctness of the load equations was verified through equation error and inspection error analysis.Finally,the actual flight load of the wing was obtained through flight tests. 展开更多
关键词 Aircraft wing load Linear stepwise regression method Strain measurement MIV algorithm Load equation
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Study on the Variation of Ningxia Climate Productive Potential under the Returning Farmland to Forestland and Grassland Background
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作者 李剑萍 官景得 +4 位作者 刘建军 韩颖娟 王石立 马玉平 苏延勇 《Agricultural Science & Technology》 CAS 2011年第3期456-460,共5页
The key zones of returning farmland to forestland and grassland in Ningxia were studied. By using the "stepwise revised method",the climate productive potential,light and temperature productive potential in the zone... The key zones of returning farmland to forestland and grassland in Ningxia were studied. By using the "stepwise revised method",the climate productive potential,light and temperature productive potential in the zone in recent 50 years were counted. The light and temperature productive potential of corn in Ningxia irrigated area,the central arid zone and the southern mountain area presented the linear increase trend. But when considered the climate productive potentials of light,temperature and water,the numerical value was very low because of the scarce rainfall,and no agriculture without the irrigation. The light and temperature productive potential,climate productive potential of winter wheat in the central arid zone had no significant trend,but the variation range of climate productive potential was very big. The light and temperature productive potential of winter wheat in the southern mountain area had no significant variation trend,and the climate productive potential presented the weak decline trend. It illustrated that the productive of winter wheat was greatly restricted by the water content. By using the meteorological factor data which were simulated by RegCM3-WOFOST/LINGRA coupled model,the future climate productive potentials of winter wheat in the central south of Ningxia was counted. They both presented the weak increase trend. It illustrated that the climate in Ningxia was favorable to improve the yield of winter wheat after returning farmland to forestland. 展开更多
关键词 stepwise revised method Light and temperature productive potential Climate productive potential
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Optimal Design of Water Utilization Network with Energy Integration in Process Industries 被引量:6
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作者 都健 孟小琼 +3 位作者 杜红彬 俞红梅 樊希山 姚平经 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第2期247-255,共9页
Effective utilization of water and energy is the key factor of sustainable development in process industries, and also an important science and technology problem to be solved in systems engineering. In this paper,two... Effective utilization of water and energy is the key factor of sustainable development in process industries, and also an important science and technology problem to be solved in systems engineering. In this paper,two new methods of optimal design of water utilization network with energy integration in process industries are presented, that is, stepwise and simultaneous optimization methods. They are suitable for both single contaminant and multi-contaminant systems, and the integration of energy can be carried out in the whole process system, not only limited in water network, so that energy can be utilized effectively. The two methods are illustrated by case study. 展开更多
关键词 utilization of water and energy MINIMIZATION stepwise optimization method simultaneous optimization method
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Assessment of different genetic distances in constructing cotton core subset by genotypic values 被引量:7
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作者 Jian-cheng WANG Jin HU +1 位作者 Xin-xian HUANG Sheng-chun XU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2008年第5期356-362,共7页
One hundred and sixty-eight genotypes of cotton from the same growing region were used as a germplasm group to study the validity of different genetic distances in constructing cotton core subset. Mixed linear model a... One hundred and sixty-eight genotypes of cotton from the same growing region were used as a germplasm group to study the validity of different genetic distances in constructing cotton core subset. Mixed linear model approach was employed to unbiasedly predict genotypic values of 20 traits for eliminating the environmental effect. Six commonly used genetic distances(Euclidean,standardized Euclidean,Mahalanobis,city block,cosine and correlation distances) combining four commonly used hierarchical cluster methods(single distance,complete distance,unweighted pair-group average and Ward's methods) were used in the least distance stepwise sampling(LDSS) method for constructing different core subsets. The analyses of variance(ANOVA) of different evaluating parameters showed that the validities of cosine and correlation distances were inferior to those of Euclidean,standardized Euclidean,Mahalanobis and city block distances. Standardized Euclidean distance was slightly more effective than Euclidean,Mahalanobis and city block distances. The principal analysis validated standardized Euclidean distance in the course of constructing practical core subsets. The covariance matrix of accessions might be ill-conditioned when Mahalanobis distance was used to calculate genetic distance at low sampling percentages,which led to bias in small-sized core subset construction. The standardized Euclidean distance is recommended in core subset construction with LDSS method. 展开更多
关键词 Core subset Mixed linear model Least distance stepwise sampling (LDSS) method Standardized Euclidean distance Mahalanobis distance
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Operating speed models for curved segments of highways in plateau regions 被引量:2
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作者 Wang Chenzhu Chen Fei +4 位作者 Xu Wensheng Wu Yutao Zhang Yunlong Bo Wu Zhang Ping 《Journal of Southeast University(English Edition)》 EI CAS 2022年第1期85-91,共7页
To examine the influence of the harsh environment in plateau areas on the operating speed of vehicles,advanced speed prediction models for curved segments are established based on observed actual speed data.First,the ... To examine the influence of the harsh environment in plateau areas on the operating speed of vehicles,advanced speed prediction models for curved segments are established based on observed actual speed data.First,the speed characteristics at the starting,mid,and end points of a plane curve were observed on Lalin Highway and China National Highway 318 with Bushnell s handheld radar speedometer 10-1911CN.Second,the stepwise regression method was proposed to determine the significant parameters and propose the prediction models of the operating speed of cars and large vehicles for the two highways.Finally,reserved test group data were utilized to prove the validity and practicality of the proposed models.Compared with traditional methods,the established models can produce more accurate prediction results and deeply examine the nonlinear relationships between parameters and the predicted operating speed.This study provides a considerate direction and basis for the operating speed prediction model for other segments in plateau regions. 展开更多
关键词 plateau areas operating speed stepwise regression method prediction model
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Calculating the Wave Force on Partially Immersed Large-Scale Horizontal Cylinders
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作者 LIU Bi-jin FU Dan-juan 《China Ocean Engineering》 SCIE EI CSCD 2021年第2期291-300,共10页
Large-scale interceptors constitute the main structure of offshore self-driven floating marine litter collection devices,and the structural stability of such interceptors under the action of waves directly influences ... Large-scale interceptors constitute the main structure of offshore self-driven floating marine litter collection devices,and the structural stability of such interceptors under the action of waves directly influences the overall safety of the device.When the ratio of the diameter of a horizontal cylinder in such interceptors to the incident wavelength is larger than 0.25,the wave force can be calculated by using the diffraction theory,by considering the problem as that of the interaction between the waves and a partially immersed large-scale horizontal cylinder.In this study,an analytical approach to calculate the wave force on a partially immersed large-scale horizontal cylinder was formulated by using the stepwise approximation method.Physical model tests were conducted to investigate the effects of different factors(wave height,period,and immersion depth)on the wave force on a large-scale horizontal cylinder under conditions involving short-period waves.The results show that both horizontal and vertical wave forces on the cylinder increase as the wave height(immersion depth)increases in most cases.The vertical wave force decreases with the decrease of the period.For the horizontal wave force,it increases with the decrease of the period when the wavelength is larger than the diameter of the cylinder and decreases with the decrease of the period when the wavelength is smaller than the diameter of the cylinder. 展开更多
关键词 wave force large-scale horizontal cylinder diffraction theory partial immersion stepwise approximation method
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Estimating water deficit and its uncertainties in water-scarce area using integrated modeling approach
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作者 Shou-ke WEI 《Water Science and Engineering》 EI CAS 2012年第4期450-463,共14页
Accurate assessment of water deficit and related uncertainties in water-scarce areas is strategically important in various fields of water resources management. This study developed a hybrid approach integrating conce... Accurate assessment of water deficit and related uncertainties in water-scarce areas is strategically important in various fields of water resources management. This study developed a hybrid approach integrating conceptual water balance model and econometric regression to estimate water shortage and its related uncertainties in water-scarce areas. This hybrid approach was used to assess the agricultural water deficit of Beijing, an extremely water-scarce area in China. A predictive model of agricultural water demand was developed using the stepwise multiple regression method, and was validated by comparing the predicted values with observed data. Scenario analysis was employed to investigate the uncertainties of agricultural water shortage and agricultural water demand. This modeling approach can assist water administration in creating sustainable water allocation strategies in water-scarce areas. 展开更多
关键词 water deficit hybrid model conceptual water balance model stepwise multipleregression method UNCERTAINTY Beo'ing
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Region stepwise reconstruction method based on two source–detector-separation groups for reconstructing background optical properties of two-layered slab sample
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作者 刘明 贾梦宇 +1 位作者 赵会娟 高峰 《Chinese Optics Letters》 SCIE EI CAS CSCD 2014年第11期75-80,共6页
The accuracy of the background optical properties has a considerable effect on the quality of reconstructed images in near-infrared functional brain imaging based on continuous wave diffuse optical tomography(CW-DOT... The accuracy of the background optical properties has a considerable effect on the quality of reconstructed images in near-infrared functional brain imaging based on continuous wave diffuse optical tomography(CW-DOT). We propose a region stepwise reconstruction method in CW-DOT scheme for reconstructing the background absorption and reduced scattering coefficients of the two-layered slab sample with the known geometric information. According to the relation between the thickness of the top layer and source– detector separation, the conventional measurement data are divided into two groups and are employed to reconstruct the top and bottom background optical properties, respectively. The numerical simulation results demonstrate that the proposed method can reconstruct the background optical properties of two-layered slab sample effectively. The region-of-interest reconstruction results are better than those of the conventional simultaneous reconstruction method. 展开更多
关键词 Region stepwise reconstruction method based on two source detector-separation groups for reconstructing background optical properties of two-layered slab sample than
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Theoretical and Empirical Analysis on Influence Factors of Modern Agricultural Equipment Level in the Processof Agricultural Sustainable Development
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作者 Yan Tingwu Li Lingchao Wang Wang Ruixue 《Chinese Journal of Population,Resources and Environment》 2012年第1期105-110,共6页
To promote modem agricultural equipment level is one characteristic of constructing and developing modem agriculture in China. This paper makes up stepwise linear regression analysis model of influence factors of mode... To promote modem agricultural equipment level is one characteristic of constructing and developing modem agriculture in China. This paper makes up stepwise linear regression analysis model of influence factors of modem agricultural equipment level, and chooses rural labor, per capita income of rural residents, rural investment, proportion of people at secondary education level and at higher level in per hundred rural labor force and arable land area as independent variables, and total power of machine as induced variable. The major results show that the relativity of modem ag- ricultural equipment level, rural investment and education level of peasants is remarkable, and they are the major influence factors of modem agricultural equipment level. Raising investment level of rural infrastructure construction as well as and research and devel- opment and promotion of advanced and applicable modem agricultural equipment, improving quality and education level of peasants can accelerate the development of China's modern agricultural equipment effectively in the process of agricultural sustainable development. 展开更多
关键词 modern agricultural equipment level influence factors MODEL stepwise linear regression method agricultural sus-tainable development
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Stepwise shape optimization of the surface of a vibrating screen 被引量:5
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作者 Guolang Shen Zhiquan Chen +2 位作者 Xiaoqiu Wu Zhanfu Li Xin Tong 《Particuology》 SCIE EI CAS CSCD 2021年第5期26-34,共9页
Screening is a technique that is extensively adopted for the separation of discrete materials according to particle characteristics such as size and shape.Wide application of the discrete element method has sparked mu... Screening is a technique that is extensively adopted for the separation of discrete materials according to particle characteristics such as size and shape.Wide application of the discrete element method has sparked much research on the vibrating screen,which is a screening apparatus having a specific vibration mode.The shape of the screen surface is a critical factor affecting the sieving performance of the vibrating screen.In this paper,a stepwise optimization method is employed to optimize the screen surface shape of the vibrating screen in discrete element modeling to obtain a high screening efficiency and large processing capacity simultaneously.Adopting this optimization method,a new curved screen with five decks having various inclination angles is presented.Numerical simulations and prototype experiments are conducted to verify the superior sieving performance of the new curved screen.Experimental results clearly show that the new curved screen greatly outperforms three commonly used screens in terms of sieving performance.The conclusions and methodologies of this work will benefit the design and improvement of vibrating screens. 展开更多
关键词 Discrete element method Vibrating screen Screen surface shape stepwise optimization method Sieving performance
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A new scheme of climate-vegetation regionalization in the Hengduan Mountains Region
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作者 Xueqin ZHANG Xiaoming XU +2 位作者 Xiang LI Peng CUI Du ZHENG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第3期751-768,共18页
The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributi... The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributions of climate and vegetation exhibit significant regional differentiation and vertical zonality due to the rugged longitudinal ranges and gorges and the complex disaster-prone environments in HMR. Therefore, it is urgent to develop the climate-vegetation regionalization in HMR to effectively satisfy the national requirements such as agricultural production and ecological protection, mountain disaster risk prevention, and major project construction. We here develop a new scheme of climate-vegetation regionalization with the latest demarcation outcome of HMR, the ground observation from 122 meteorological stations in HMR and its surrounding areas during 1990–2019, and the high-precision remote sensing data of land cover types. The new scheme first constructs the regionalization index system, fully considering the extraordinarily complicated geomorphic pattern of mountains and valleys, the scarcity of meteorological observations, and the remarkable differentiation of climate and vegetation in HMR. The system consists of three primary regionalization indices(i.e., days with daily average temperature steady above 10°C, aridity index, and main vegetation types, dividing the temperature zones, moisture regions, and vegetation subregions, respectively) and three auxiliary indices of the accumulated temperature above 10°C, and the temperatures in January and July. Then, the HMR is divided into five temperature zones, 20 moisture regions, and 55 vegetation subregions. Compared with previous regionalization schemes, the new scheme optimizes the climate spatial interpolation model of thin plate smoothing spline suitable for the unique terrain in HMR. Moreover, the disputed division index threshold between different climatic zones(regions) is scientifically clarified using geographical detectors. Specifically, the stepwise downscaling pane division method is initially proposed to determine the zoning boundary, alleviating the excessive dependence of the traditional zoning method on subjective experience.Besides, the scheme considers the typical regional characteristics of the complex underlying surface and the high gradient zone of climate-vegetation distribution types in HMR. Consequently, the transition zone with quick climate changes between the plateau temperate and mid-subtropical zones is divided into mountainous subtropics, taking into account the spatial distribution characteristics of climate-vegetation regionalization indices. The regionalization scheme will provide practically theoretical support for agricultural production, ecological protection, major project construction, disaster prevention and relief efforts, and other socioeconomic activities in HMR, serving as a classic case of climate-vegetation regionalization for the alpine and canyon regions with intricate underlying surface, striking regional differences, and lack of ground observations. 展开更多
关键词 Climate-vegetation regionalization Thin plate smoothing spline(TPSS) GeoDetector stepwise downscaling pane division method Hengduan Mountains Region
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Parameter Identification for Static Var Compensator Model Using Sensitivity Analysis and Improved Whale Optimization Algorithm 被引量:4
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作者 Qiang Guo Lei Gao +1 位作者 Xiaojie Chu Huadong Sun 《CSEE Journal of Power and Energy Systems》 SCIE EI CSCD 2022年第2期535-547,共13页
A parameter estimation method based on an improved Whale Optimization Algorithm is proposed in this paper to identify the parameters of a static var compensator(SVC)model.First,a mathematical model of SVC is establish... A parameter estimation method based on an improved Whale Optimization Algorithm is proposed in this paper to identify the parameters of a static var compensator(SVC)model.First,a mathematical model of SVC is established.Then,the reverse learning strategy and Levy flight disturbance strategy are introduced to improve the whale optimization algorithm,and the improved whale optimization algorithm is applied to the parameter identification of the static var compensator model.Finally,a stepwise identification method,by analyzing the local sensitivities of parameters,is proposed which solves the problem of low accuracy caused by multi-parameter identification.This method provides a new estimation strategy for accurately identifying the parameters of the static var compensator model.Estimation results show that the parameter estimation method can be an effective tool to solve the problem of parameter identification for the SVC model. 展开更多
关键词 Local sensitivity analysis parameter estimation static var compensator model stepwise identification method whale Optimization Algorithm
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