The Components having calcium antagonist effect were isolated from richosanthes with 70% C 2H 5OH.The analytical data showed that the mixture was composed of saturated aliphatic acids,spinasterol and 24 dihydro 10α c...The Components having calcium antagonist effect were isolated from richosanthes with 70% C 2H 5OH.The analytical data showed that the mixture was composed of saturated aliphatic acids,spinasterol and 24 dihydro 10α cucurbitadienol.展开更多
以酒石酸泰乐菌素为底药,探讨α-菠菜甾醇对小鼠小肠段药物转运体P-gp和PEPT1表达的影响。48只小鼠分为4组:α-菠菜甾醇组,酒石酸泰乐菌素组,α-菠菜甾醇和酒石酸泰乐菌素混合组,生理盐水对照组。每组按0.2 m L·10 g^(-1)体质量的...以酒石酸泰乐菌素为底药,探讨α-菠菜甾醇对小鼠小肠段药物转运体P-gp和PEPT1表达的影响。48只小鼠分为4组:α-菠菜甾醇组,酒石酸泰乐菌素组,α-菠菜甾醇和酒石酸泰乐菌素混合组,生理盐水对照组。每组按0.2 m L·10 g^(-1)体质量的剂量每天灌胃一次,共灌胃5 d,分别在1,3,5 d后处死1批采样。采用免疫组化的方法测定1,3,5 d的小鼠肠道上P-gp和PEPT1的表达。试验结果表明,α-菠菜甾醇组和混合组相对于对照组外排性药物转运体P-gp表达减少,而摄取性药物转运体PEPT1表达增多;酒石酸泰乐菌素组的外排性药物转运体P-gp表达增多,摄取性药物转运体PEPT1表达减少;且都随着用药时间的延长差异增大。表明α-菠菜甾醇具有抑制药物转运体P-gp表达和促进药物转运体PEPT1表达的作用。展开更多
文摘The Components having calcium antagonist effect were isolated from richosanthes with 70% C 2H 5OH.The analytical data showed that the mixture was composed of saturated aliphatic acids,spinasterol and 24 dihydro 10α cucurbitadienol.
