The genus Actinidia is primarily functionally dioecious,and early sex identification plays a crucial role in improving breeding efficiency and reducing production costs.In this study,the accuracy of three sex-linked m...The genus Actinidia is primarily functionally dioecious,and early sex identification plays a crucial role in improving breeding efficiency and reducing production costs.In this study,the accuracy of three sex-linked molecular markers(SyGI[Shy Girl],FrBy[Friendly Boy],and SmY1)in sex identification was evaluated in various Actinidia species.The selected marker products were subsequently cloned and sequenced in six wild Actinidia species.Ninety-six wild A.chinensis chinensis accessions and 74 A.chinensis deliciosa accessions,most of which were wild,with only one cultivated,were used for comprehensive primer validation.Thirty-three juvenile A.chinensis chinensis hybrid seedlings were used for practical application tests.The results showed that the marker SyGI accurately identified the sex of 20 samples from six Actinidia species and 96 A.chinensis chinensis accessions with 100%reliability.For Actinidia chinensis deliciosa,the identification accuracy reached 98.65%.Sequence analysis revealed that SyGI shared the highest similarity with the male-specific genomic region.Furthermore,SyGI achieved 100%accuracy in identifying the sex of 33 juvenile A.chinensis chinensis individuals.The findings confirm that the SyGI marker possesses high accuracy,strong specificity,and broad applicability,making it a valuable tool for kiwifruit breeding programs.The cloned sequences from wild Actinidia species also provide important references for future research on the mechanisms of sexual evolution and determination.展开更多
With the rapid development of Internet technology,REST APIs(Representational State Transfer Application Programming Interfaces)have become the primary communication standard in modern microservice architectures,raisin...With the rapid development of Internet technology,REST APIs(Representational State Transfer Application Programming Interfaces)have become the primary communication standard in modern microservice architectures,raising increasing concerns about their security.Existing fuzz testing methods include random or dictionary-based input generation,which often fail to ensure both syntactic and semantic correctness,and OpenAPIbased approaches,which offer better accuracy but typically lack detailed descriptions of endpoints,parameters,or data formats.To address these issues,this paper proposes the APIDocX fuzz testing framework.It introduces a crawler tailored for dynamic web pages that automatically simulates user interactions to trigger APIs,capturing and extracting parameter information from communication packets.A multi-endpoint parameter adaptation method based on improved Jaccard similarity is then used to generalize these parameters to other potential API endpoints,filling in gaps in OpenAPI specifications.Experimental results demonstrate that the extracted parameters can be generalized with 79.61%accuracy.Fuzz testing using the enriched OpenAPI documents leads to improvements in test coverage,the number of valid test cases generated,and fault detection capabilities.This approach offers an effective enhancement to automated REST API security testing.展开更多
Using a recognition model of atmospheric gravity waves(AGWs),we identified 519 AGW events from the OH airglow images observed at the Dandong and Lhasa stations from 2015 to 2017.The 317 AGW events detected at the Dand...Using a recognition model of atmospheric gravity waves(AGWs),we identified 519 AGW events from the OH airglow images observed at the Dandong and Lhasa stations from 2015 to 2017.The 317 AGW events detected at the Dandong station have wavelengths ranging from 30 to 60 km,periods from 14 to 20 min,horizontal speeds from 30 to 60 m/s,and relative intensities from 0.4%to 0.6%,respectively.The parameters of 202 events recorded at the Lhasa station mainly vary within 15-35 km in horizontal wavelength,4-6 min in period,40-100 m/s in horizontal velocity,and 0.1%-0.3%in relative intensity.The occurrence rate peaks in winter and summer at Dandong and the peak in summer are absent at Lhasa because of the lack of convective weather.The seasonal propagation directions of the waves are influenced by both the wind field-filtering effect and the distribution of wave sources.In spring,because of the southeastward background wind field,fewer southeastward events are observed at the Dandong station.The situation at the Lhasa station is similar.In summer,both the Lhasa and Dandong stations are dominated by northeastward AGWs,which can be attributed to the southwestward wind.In autumn,ray-tracing results show that the events at Dandong mainly originate from wind shear,whereas the events at the Lhasa station are triggered by convective weather.The location of the wave sources determines the trend of the propagation directions at the Dandong and Lhasa stations in autumn.In winter,because of the eastward wind,more events are propagating to the southwest at the Dandong station.展开更多
The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic...The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.展开更多
Prostate-specific membrane antigen(PSMA)is a surface membrane antigen that is highly overexpressed in prostate cancer,with heterogenous expression throughout the natural history of the disease.This has generated signi...Prostate-specific membrane antigen(PSMA)is a surface membrane antigen that is highly overexpressed in prostate cancer,with heterogenous expression throughout the natural history of the disease.This has generated significant interest as a potential biomarker for use in early diagnosis and treatment of prostate cancer.We reviewed the literature surrounding PSMA and its current clinical applications in diagnosing and managing early prostate cancer that is confined to the prostate and local lymph nodes.A search on PubMed,Medline,and Web of Science was performed using the following keywords:“PSMA”,“Prostate Specific Membrane Antigen”,“Prostate cancer”,“Biomarker”,“Diagnosis”.We considered all available articles relevant to the topic of PSMA as a biomarker in early prostate cancer when developing this narrative review.Key articles assessing the biology of PSMA,as well as its use as a potential diagnostic and therapeutic target in early prostate cancer,were assessed.The role of PSMA PET as a potential diagnostic and risk stratification tool was assessed.The current use of antibody-drug conjugates and radioligand therapy targeting PSMA was assessed,along with any current evidence to support their use in early prostate cancer.PSMA is heavily expressed throughout the early stages of prostate cancer,and this has significant therapeutic implications.There is a growing body of evidence that shows PSMA PET can play a role in the diagnosis,risk stratification,and prognostication of localised prostate cancer.PSMA-targeted therapies such as Lu-177 currently do not have any proven benefit in treating early prostate cancer;however,this remains an area of ongoing research.展开更多
Coconut(Cocos nucifera L.),a major oil and fruit crop of the Arecaceae family,is extensively cultivated across the Asia—Pacific region.Despite its agricultural importance,genome assembly in coconut remains challengin...Coconut(Cocos nucifera L.),a major oil and fruit crop of the Arecaceae family,is extensively cultivated across the Asia—Pacific region.Despite its agricultural importance,genome assembly in coconut remains challenging due to its large genome size and high proportion of repetitive sequences.Allele-specific expression(ASE)plays a key role in regulating plant development and evolution,yet research on ASE in coconut is limited(Shao et al.,2019;Li et al.,2021;Zhang et al.,2021;Hu et al.,2022).Among phenotypic traits,fruit color is especially important as an indicator of maturity,guiding harvest timing and post-harvest processes(Kapoor et al.,2022).While prior studies have explored various coconut traits such as salt tolerance,fiber content,and plant height(Wang et al.,2021;Yang et al.,2021),investigations into ASE and fruit color remain scarce.展开更多
Estimation of terrestrial biomass depends critically on reliable information about wood specific gravity of forest trees. In recent years, wood specific gravity has become more important when exploring the universalit...Estimation of terrestrial biomass depends critically on reliable information about wood specific gravity of forest trees. In recent years, wood specific gravity has become more important when exploring the universality of functional traits of plants and estimating their global carbon stocks. To estimate their specific gravity, wood samples were collected from a total of 34 tree species, 30 from lower elevations and 4 from upper elevations in the Garhwal Himalayas, India. The results show that the average wood specific gravity was 0.631 （ranging between 0.275 ± 0.01 and 0.845 ± 0.03） for the species at lower elevations and 0.727 （ranging between 0.628 ± 0.02 and 0.865 ± 0.02） for the upper elevations. The average wood specific gravity for the upper elevation species was 9.6% greater than that for the species at lower elevations. Aegle marmelos among the lower elevation species and Quercus leucotrichophora among the upper elevation species had the highest wood specific gravity, which were 0.845 ± 0.03 and 0.865 ± 0.02, respectively.展开更多
To generate carbon credits under the Reducing Emissions from Deforestation and forest Degradation program（REDD＋）, accurate estimates of forest carbon stocks are needed. Carbon accounting efforts have focused on car...To generate carbon credits under the Reducing Emissions from Deforestation and forest Degradation program（REDD＋）, accurate estimates of forest carbon stocks are needed. Carbon accounting efforts have focused on carbon stocks in aboveground biomass（AGB）.Although wood specific gravity（WSG） is known to be an important variable in AGB estimates, there is currently a lack of data on WSG for Malagasy tree species. This study aimed to determine whether estimates of carbon stocks calculated from literature-based WSG values differed from those based on WSG values measured on wood core samples. Carbon stocks in forest biomass were assessed using two WSG data sets：（i） values measured from 303 wood core samples extracted in the study area,（ii） values derived from international databases. Results suggested that there is difference between the field and literaturebased WSG at the 0.05 level. The latter data set was on average 16 % higher than the former. However, carbon stocks calculated from the two data sets did not differ significantly at the 0.05 level. Such findings could be attributed to the form of the allometric equation used which gives more weight to tree diameter and tree height than to WSG. The choice of dataset should depend on the level of accuracy（Tier II or III） desired by REDD＋. As higher levels of accuracy are rewarded by higher prices, speciesspecific WSG data would be highly desirable.展开更多
We studied radial and inter-progeny variations in the dimen- sions of the wood elements and specific gravity of 21 half sib progenies of Populus deltoides Bartr. ex Marsh. The female parents of half sib progenies were...We studied radial and inter-progeny variations in the dimen- sions of the wood elements and specific gravity of 21 half sib progenies of Populus deltoides Bartr. ex Marsh. The female parents of half sib progenies were G48 and $7C13 clones. Variance ratio （F） test indicated that inter-progeny variations in the dimensions of wood elements and specific gravity were significant for all wood traits while variations were significant for radial location for specific gravity only. Hierarchical clus- ter analysis was done by Squared Euclidean Distance for all of 21 proge- nies considering six wood traits. 21 progenies were grouped into 4 clus- ters. Cluster 1 was the largest cluster with 11 progenies, whereas cluster 3 had only one progeny. Selected progenies in clusters 3 （progeny 155, male） and 4 （progeny 108, 196, both female） were highly divergent from the other progenies so they were used in combinations as parents of hybrids to develop new clones with desired characters. Progeny 155 showed higher growth, fiber dimensions, and specific gravity, thus, should be used for the development of new clones.展开更多
In this study, we investigated the specific gravity of wood samples collected from a total of 31 woody spe- cies, consisting of 20 trees, 10 shrubs and one species of bamboo from sub-tropical regions of Garhwal Himala...In this study, we investigated the specific gravity of wood samples collected from a total of 31 woody spe- cies, consisting of 20 trees, 10 shrubs and one species of bamboo from sub-tropical regions of Garhwal Himalayas, In- dia. Results show that among these woody species, the specific gravity of trees ranged from 0.34 for Erythrina suberosa to 0.83 for Albizia procera. For shrub species the specific gravity of Ricinus communis was 0.39 and that of Dodonaea viscosa 0.93. The average specific gravity of trees was 0.58 and of shrubs 0.66.展开更多
Variations of wood specific gravity and extractive contents from pith to bark and from base to the top of tree were investigated in a 14-year-old commercial pulpwood species Sterculia setigera Del. Growing in savanna ...Variations of wood specific gravity and extractive contents from pith to bark and from base to the top of tree were investigated in a 14-year-old commercial pulpwood species Sterculia setigera Del. Growing in savanna zone in Nigeria. Tree mean specific gravity averaged 0.37; wood at the base had significant higher specific gravity than those at the top while it increased from pith to bark. For extractive content mean value was 1.20% for wood and 1.72% for bark; i[t varied significantly between trees and from base of the tree to the top and from pith to the bark. Extractive content at the butt and breast height is more than double of the value at the top of the tree. The high extractive content at the base is similar to high specific gravity observed for wood samples from the base. Extractive content of the bast was significantly higher than that of the wood. The low specific gravity show possible suitability of the species for paper making in Nigerian paper mills. The wood of Sterculia setigera showed a significant variation between- and within-trees in the two properties considered, though the wood is light with low extractive content; it is however a potential raw material for large scale pulpwood production in Nigeria.展开更多
combined with sufentanil in elderly patients undergoing hip replacement.Methods:89 elderly patients with hip arthroplasty from July 2019 to September 2020 were randomly divided into experimental group and control grou...combined with sufentanil in elderly patients undergoing hip replacement.Methods:89 elderly patients with hip arthroplasty from July 2019 to September 2020 were randomly divided into experimental group and control group.The experimental group was anesthetized with light specific gravity ropivacaine combined with sufentanil.The control group was anesthetized with equal specific gravity ropivacaine to compare the effect of anesthesia and the incidence of adverse reactions.Results:there was no significant difference in sensory recovery time and motor recovery time between the experimental group and the control group(P>0.05),and the incidence of adverse reactions between the two groups was low.The sensory block time in the experimental group was shorter than that in the control group(PP>0.05).Conclusion:ropivacaine combined with sufentanil subarachnoid anesthesia is more effective in elderly patients undergoing hip arthroplasty,and the safety of the anesthesia scheme is higher,which will not lead to serious adverse reactions during operation.Moreover,the application of the anesthesia scheme can effectively improve the analgesic effect during and after operation,and the clinical application value is high.展开更多
Purpose: When considering about adeno-tonsillar hypertrophies it is important to know their weights as well as their specific gravities. Subjects and methods: Specific gravities of 344 tonsils and 117 adenoids were me...Purpose: When considering about adeno-tonsillar hypertrophies it is important to know their weights as well as their specific gravities. Subjects and methods: Specific gravities of 344 tonsils and 117 adenoids were measured. Results: Average specific gravities of tonsils and adenoids were 1.08 (SD: 0.0411), 1.12 (SD: 0.574) respectively. Significant difference was observed between two (p 0.002). Discussion: The palatine tonsils and pharyngeal tonsil or adenoid are in a Waldeyer’s ring. They are thought that they work for lymphatic immune systems. However, there are several differences between tonsil and adenoid. The former has capsule, and increases their weight by growth;on the contrary the latter has no capsule, shrinks by growth. Tonsils are relatively hard mass but adenoids are very soft and easily bleed by touching with cotton swabs via nose. Conclusion: At this study, specific gravity of the adenoid was heavier than that of tonsils. These results suggest that tonsil and adenoid are physiologically different.展开更多
Mathematical solutions predict abstract conditions that indicate limits or bounds for physical processes. Generally, experimental verifications and physical observations on physical processes validate the mathematical...Mathematical solutions predict abstract conditions that indicate limits or bounds for physical processes. Generally, experimental verifications and physical observations on physical processes validate the mathematical predictions. Sometimes these predictions lead to new theories and concepts that form basis of better understanding of the natural processes. Gravitational interactions between bodies are natural physical processes. A smaller body moves under the influence of gravity, due to the gravitational effect of another large body. Newton’s classical gravitational theory addresses the interactions at low velocities. Einstein’s general relativity provides firm basis for gravitational interactions. Observations over past 100 years prove the mathematical precision and predictions of general relativity. Einstein’s special relativity forms the foundation of quantum physics. In this paper, the author applies concepts of special relativity to classical two body Newtonian gravitational problem. The study predicts a new mathematically viable condition that when a body moves at a specific velocity derived in this paper, the total energy of the moving body is zero. The specific velocity is a constant. At velocities far less than specific velocity, the total energy is negative and is equal to classical value of half the potential energy. At velocities, greater the specific velocity the total energy is positive. The specific velocity condition also enables determination of specific mass of gravitating body, as well as the specific distance of the moving body from gravitating body, at which the total energy of moving body is zero.展开更多
In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively understood.In this article,we discuss the effects of mesoscale G...In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively understood.In this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high resolution.Driven by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower altitudes.The effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the GWs.The mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their thickness.In addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.展开更多
A 3D crustal model was constructed using a combination of cutting-edge techniques,which were integrated to provide a density model for Egypt and address the sporadic distribution of seismic data.These techniques inclu...A 3D crustal model was constructed using a combination of cutting-edge techniques,which were integrated to provide a density model for Egypt and address the sporadic distribution of seismic data.These techniques include obtaining gravity data from the Gravity Field and Steady-State Ocean Circulation Explorer(GOCE),creating seismic profiles,analyzing the receiver functions of seismic data,obtaining information from boreholes,and providing geological interpretations.GOCE satellite gravity data were processed to construct a preliminary model based on nonlinear inversions of the data.A regional crustal thickness model was developed using receiver functions,seismic refraction profiles,and geological insights.The inverted model was validated using borehole data and compared with seismic estimates.The model exhibited strong consistency and revealed a correlation between crustal thickness,geology,and tectonics of Egypt.It showed that the shallowest depths of the Moho are located in the north along the Mediterranean Sea and in the eastern part along the Red Sea,reflecting an oceanic plate with a thin,high-density crust.The deepest Moho depths are located in the southwestern part of Egypt,Red Sea coastal mountains,and Sinai Peninsula.The obtained 3D model of crustal thickness provided finely detailed Moho depth estimates that aligned closely with geology and tectonic characteristics of Egypt,contributing valuable insights into the subsurface structure and tectonic processes of region.展开更多
Comprehensive utilization of phosphogypsum(PG)has attracted much attention,especially for the recovery of rare earth elements(REEs)and gypsum due to the issues of stockpile,environmental pollution,and waste of associa...Comprehensive utilization of phosphogypsum(PG)has attracted much attention,especially for the recovery of rare earth elements(REEs)and gypsum due to the issues of stockpile,environmental pollution,and waste of associated resources.Traditional utilization methods suffered the issues of low REEs leaching efficiency,huge amount of CaSO_(4)saturated wastewater and high recovery cost.To solve these issues,this study investigated the occurrence of REEs in PG and the leaching of REEs.The results show that REEs in PG are in the forms of(1)REEs mineral inclusions,(2)REEs isomorphous substitution of Ca^(2+)in gypsum lattice,(3)dispersed soluble REEs salts.Acid leaching results demonstrate that(1)the dissolution of gypsum matrix is the control factor of REEs leaching;(2)H_(2)SO_(4)is a promising leachant considering the recycle of leachate;(3)the gypsum matrix suffers a recrystallization during the acid leaching and releases the soluble REEs from PG to aqueous solution.For the recovery of the undissolved REEs mineral inclusions,wet sieving concentrated 37.1 wt%of the REEs in a 10.7 wt%mass,increasing REEs content from 309 to 1071 ppm.Finally,a green process combining gravity separation and hydrometallurgy is proposed.This process owns the merits of wastewater free,considerable REEs recovery(about 10%increase compared with traditional processes),excellent gypsum purification(>95 wt%CaSO_(4)·2H_(2)O,with<0.06 wt%of soluble P_(2)O_(5) and<0.015 wt%of soluble F)and reagent saving(about 2/3less reagent consumption than non-cyclical leaching).展开更多
A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%...A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%for 93 compounds and is particularly useful to those substances for which the normal boiling points are stillunknown.展开更多
Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectro...Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectroscopy.The results showed that copper minerals exhibited various forms and uneven particle sizes,while cobalt existed in the form of highly dispersed asbolane,and large amounts of easily slimed gangue minerals were filled in the samples,making it difficult to separate copper and cobalt minerals.The particle size range plays a decisive role in selecting the separation method for the copper−cobalt ore.Gravity separation was suitable for particles ranging from 43 to 246μm,while flotation was more effective for particles below 43μm.After ore grinding and particle size classification,applying a combined gravity separation(shaking table)−flotation method yielded concentrated minerals with a copper recovery of 72.83%and a cobalt recovery of 31.13%.展开更多
基金funded by Sichuan Science and Technology Program,grant numbers 2021YFYZ0010,2023YFH0006,2025YFHZ0295The Basic Research Program of Sichuan Provincial Research Institutes,grant numbers 2024JDKY0001 and 2023JDKY0001.
文摘The genus Actinidia is primarily functionally dioecious,and early sex identification plays a crucial role in improving breeding efficiency and reducing production costs.In this study,the accuracy of three sex-linked molecular markers(SyGI[Shy Girl],FrBy[Friendly Boy],and SmY1)in sex identification was evaluated in various Actinidia species.The selected marker products were subsequently cloned and sequenced in six wild Actinidia species.Ninety-six wild A.chinensis chinensis accessions and 74 A.chinensis deliciosa accessions,most of which were wild,with only one cultivated,were used for comprehensive primer validation.Thirty-three juvenile A.chinensis chinensis hybrid seedlings were used for practical application tests.The results showed that the marker SyGI accurately identified the sex of 20 samples from six Actinidia species and 96 A.chinensis chinensis accessions with 100%reliability.For Actinidia chinensis deliciosa,the identification accuracy reached 98.65%.Sequence analysis revealed that SyGI shared the highest similarity with the male-specific genomic region.Furthermore,SyGI achieved 100%accuracy in identifying the sex of 33 juvenile A.chinensis chinensis individuals.The findings confirm that the SyGI marker possesses high accuracy,strong specificity,and broad applicability,making it a valuable tool for kiwifruit breeding programs.The cloned sequences from wild Actinidia species also provide important references for future research on the mechanisms of sexual evolution and determination.
基金supported by the Open Foundation of Key Laboratory of Cyberspace Security,Ministry of Education of China(KLCS20240211)。
文摘With the rapid development of Internet technology,REST APIs(Representational State Transfer Application Programming Interfaces)have become the primary communication standard in modern microservice architectures,raising increasing concerns about their security.Existing fuzz testing methods include random or dictionary-based input generation,which often fail to ensure both syntactic and semantic correctness,and OpenAPIbased approaches,which offer better accuracy but typically lack detailed descriptions of endpoints,parameters,or data formats.To address these issues,this paper proposes the APIDocX fuzz testing framework.It introduces a crawler tailored for dynamic web pages that automatically simulates user interactions to trigger APIs,capturing and extracting parameter information from communication packets.A multi-endpoint parameter adaptation method based on improved Jaccard similarity is then used to generalize these parameters to other potential API endpoints,filling in gaps in OpenAPI specifications.Experimental results demonstrate that the extracted parameters can be generalized with 79.61%accuracy.Fuzz testing using the enriched OpenAPI documents leads to improvements in test coverage,the number of valid test cases generated,and fault detection capabilities.This approach offers an effective enhancement to automated REST API security testing.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFF0711402)the Specialized Research Fund for State Key Laboratories。
文摘Using a recognition model of atmospheric gravity waves(AGWs),we identified 519 AGW events from the OH airglow images observed at the Dandong and Lhasa stations from 2015 to 2017.The 317 AGW events detected at the Dandong station have wavelengths ranging from 30 to 60 km,periods from 14 to 20 min,horizontal speeds from 30 to 60 m/s,and relative intensities from 0.4%to 0.6%,respectively.The parameters of 202 events recorded at the Lhasa station mainly vary within 15-35 km in horizontal wavelength,4-6 min in period,40-100 m/s in horizontal velocity,and 0.1%-0.3%in relative intensity.The occurrence rate peaks in winter and summer at Dandong and the peak in summer are absent at Lhasa because of the lack of convective weather.The seasonal propagation directions of the waves are influenced by both the wind field-filtering effect and the distribution of wave sources.In spring,because of the southeastward background wind field,fewer southeastward events are observed at the Dandong station.The situation at the Lhasa station is similar.In summer,both the Lhasa and Dandong stations are dominated by northeastward AGWs,which can be attributed to the southwestward wind.In autumn,ray-tracing results show that the events at Dandong mainly originate from wind shear,whereas the events at the Lhasa station are triggered by convective weather.The location of the wave sources determines the trend of the propagation directions at the Dandong and Lhasa stations in autumn.In winter,because of the eastward wind,more events are propagating to the southwest at the Dandong station.
基金financial support from the National Natural Science Foundation of China (Nos.82473887 and 21927808)the Scientific and Technological Innovation Program of Shanghai (No.23DZ2202500)the CAMS Innovation Fund for Medical Sciences (No.2021-1-I2M-026)。
文摘The brain's functions are governed by molecular metabolic networks.However,due to the sophisticated spatial organization and diverse activities of the brain,characterizing both the minute and large-scale metabolic activity across the entire brain and its numerous micro-regions remains incredibly challenging.Here,we offer a high-definition spatially resolved metabolomics technique to better understand the metabolic specialization and interconnection throughout the mouse brain using improved ambient mass spectrometry imaging.This method allows for the simultaneous mapping of thousands of metabolites at a 30 μm spatial resolution across the mouse brain,ranging from structural lipids to functional neurotransmitters.This approach effectively reveals the distribution patterns of delicate microregions and their distinctive metabolic characteristics.Using an integrated database,we annotated 259 metabolites,demonstrating that the metabolome and metabolic pathways are unique to each brain microregion.The distribution of metabolites,closely linked to functionally connected brain regions and their interactions,offers profound insights into the complexity of chemical processes and their roles in brain function.An initial dataset for future metabolomics research might be obtained from the high-definition mouse brain's spatial metabolome atlas.
文摘Prostate-specific membrane antigen(PSMA)is a surface membrane antigen that is highly overexpressed in prostate cancer,with heterogenous expression throughout the natural history of the disease.This has generated significant interest as a potential biomarker for use in early diagnosis and treatment of prostate cancer.We reviewed the literature surrounding PSMA and its current clinical applications in diagnosing and managing early prostate cancer that is confined to the prostate and local lymph nodes.A search on PubMed,Medline,and Web of Science was performed using the following keywords:“PSMA”,“Prostate Specific Membrane Antigen”,“Prostate cancer”,“Biomarker”,“Diagnosis”.We considered all available articles relevant to the topic of PSMA as a biomarker in early prostate cancer when developing this narrative review.Key articles assessing the biology of PSMA,as well as its use as a potential diagnostic and therapeutic target in early prostate cancer,were assessed.The role of PSMA PET as a potential diagnostic and risk stratification tool was assessed.The current use of antibody-drug conjugates and radioligand therapy targeting PSMA was assessed,along with any current evidence to support their use in early prostate cancer.PSMA is heavily expressed throughout the early stages of prostate cancer,and this has significant therapeutic implications.There is a growing body of evidence that shows PSMA PET can play a role in the diagnosis,risk stratification,and prognostication of localised prostate cancer.PSMA-targeted therapies such as Lu-177 currently do not have any proven benefit in treating early prostate cancer;however,this remains an area of ongoing research.
基金supported by Central Public-interest Scientific Institution Basal Research Fund(CATAS-Nos.1630152023007,1630152023011,1630152023012,1630152023013)the National Natural Science Foundation of China(Grant No.32071805).
文摘Coconut(Cocos nucifera L.),a major oil and fruit crop of the Arecaceae family,is extensively cultivated across the Asia—Pacific region.Despite its agricultural importance,genome assembly in coconut remains challenging due to its large genome size and high proportion of repetitive sequences.Allele-specific expression(ASE)plays a key role in regulating plant development and evolution,yet research on ASE in coconut is limited(Shao et al.,2019;Li et al.,2021;Zhang et al.,2021;Hu et al.,2022).Among phenotypic traits,fruit color is especially important as an indicator of maturity,guiding harvest timing and post-harvest processes(Kapoor et al.,2022).While prior studies have explored various coconut traits such as salt tolerance,fiber content,and plant height(Wang et al.,2021;Yang et al.,2021),investigations into ASE and fruit color remain scarce.
文摘Estimation of terrestrial biomass depends critically on reliable information about wood specific gravity of forest trees. In recent years, wood specific gravity has become more important when exploring the universality of functional traits of plants and estimating their global carbon stocks. To estimate their specific gravity, wood samples were collected from a total of 34 tree species, 30 from lower elevations and 4 from upper elevations in the Garhwal Himalayas, India. The results show that the average wood specific gravity was 0.631 （ranging between 0.275 ± 0.01 and 0.845 ± 0.03） for the species at lower elevations and 0.727 （ranging between 0.628 ± 0.02 and 0.865 ± 0.02） for the upper elevations. The average wood specific gravity for the upper elevation species was 9.6% greater than that for the species at lower elevations. Aegle marmelos among the lower elevation species and Quercus leucotrichophora among the upper elevation species had the highest wood specific gravity, which were 0.845 ± 0.03 and 0.865 ± 0.02, respectively.
基金supported by TWAS (The World Academy of Sciences) and CIRAD (Centre de Coopération Internationale en Recherche Agronomique pour le Développement)
文摘To generate carbon credits under the Reducing Emissions from Deforestation and forest Degradation program（REDD＋）, accurate estimates of forest carbon stocks are needed. Carbon accounting efforts have focused on carbon stocks in aboveground biomass（AGB）.Although wood specific gravity（WSG） is known to be an important variable in AGB estimates, there is currently a lack of data on WSG for Malagasy tree species. This study aimed to determine whether estimates of carbon stocks calculated from literature-based WSG values differed from those based on WSG values measured on wood core samples. Carbon stocks in forest biomass were assessed using two WSG data sets：（i） values measured from 303 wood core samples extracted in the study area,（ii） values derived from international databases. Results suggested that there is difference between the field and literaturebased WSG at the 0.05 level. The latter data set was on average 16 % higher than the former. However, carbon stocks calculated from the two data sets did not differ significantly at the 0.05 level. Such findings could be attributed to the form of the allometric equation used which gives more weight to tree diameter and tree height than to WSG. The choice of dataset should depend on the level of accuracy（Tier II or III） desired by REDD＋. As higher levels of accuracy are rewarded by higher prices, speciesspecific WSG data would be highly desirable.
文摘We studied radial and inter-progeny variations in the dimen- sions of the wood elements and specific gravity of 21 half sib progenies of Populus deltoides Bartr. ex Marsh. The female parents of half sib progenies were G48 and $7C13 clones. Variance ratio （F） test indicated that inter-progeny variations in the dimensions of wood elements and specific gravity were significant for all wood traits while variations were significant for radial location for specific gravity only. Hierarchical clus- ter analysis was done by Squared Euclidean Distance for all of 21 proge- nies considering six wood traits. 21 progenies were grouped into 4 clus- ters. Cluster 1 was the largest cluster with 11 progenies, whereas cluster 3 had only one progeny. Selected progenies in clusters 3 （progeny 155, male） and 4 （progeny 108, 196, both female） were highly divergent from the other progenies so they were used in combinations as parents of hybrids to develop new clones with desired characters. Progeny 155 showed higher growth, fiber dimensions, and specific gravity, thus, should be used for the development of new clones.
文摘In this study, we investigated the specific gravity of wood samples collected from a total of 31 woody spe- cies, consisting of 20 trees, 10 shrubs and one species of bamboo from sub-tropical regions of Garhwal Himalayas, In- dia. Results show that among these woody species, the specific gravity of trees ranged from 0.34 for Erythrina suberosa to 0.83 for Albizia procera. For shrub species the specific gravity of Ricinus communis was 0.39 and that of Dodonaea viscosa 0.93. The average specific gravity of trees was 0.58 and of shrubs 0.66.
文摘Variations of wood specific gravity and extractive contents from pith to bark and from base to the top of tree were investigated in a 14-year-old commercial pulpwood species Sterculia setigera Del. Growing in savanna zone in Nigeria. Tree mean specific gravity averaged 0.37; wood at the base had significant higher specific gravity than those at the top while it increased from pith to bark. For extractive content mean value was 1.20% for wood and 1.72% for bark; i[t varied significantly between trees and from base of the tree to the top and from pith to the bark. Extractive content at the butt and breast height is more than double of the value at the top of the tree. The high extractive content at the base is similar to high specific gravity observed for wood samples from the base. Extractive content of the bast was significantly higher than that of the wood. The low specific gravity show possible suitability of the species for paper making in Nigerian paper mills. The wood of Sterculia setigera showed a significant variation between- and within-trees in the two properties considered, though the wood is light with low extractive content; it is however a potential raw material for large scale pulpwood production in Nigeria.
文摘combined with sufentanil in elderly patients undergoing hip replacement.Methods:89 elderly patients with hip arthroplasty from July 2019 to September 2020 were randomly divided into experimental group and control group.The experimental group was anesthetized with light specific gravity ropivacaine combined with sufentanil.The control group was anesthetized with equal specific gravity ropivacaine to compare the effect of anesthesia and the incidence of adverse reactions.Results:there was no significant difference in sensory recovery time and motor recovery time between the experimental group and the control group(P>0.05),and the incidence of adverse reactions between the two groups was low.The sensory block time in the experimental group was shorter than that in the control group(PP>0.05).Conclusion:ropivacaine combined with sufentanil subarachnoid anesthesia is more effective in elderly patients undergoing hip arthroplasty,and the safety of the anesthesia scheme is higher,which will not lead to serious adverse reactions during operation.Moreover,the application of the anesthesia scheme can effectively improve the analgesic effect during and after operation,and the clinical application value is high.
文摘Purpose: When considering about adeno-tonsillar hypertrophies it is important to know their weights as well as their specific gravities. Subjects and methods: Specific gravities of 344 tonsils and 117 adenoids were measured. Results: Average specific gravities of tonsils and adenoids were 1.08 (SD: 0.0411), 1.12 (SD: 0.574) respectively. Significant difference was observed between two (p 0.002). Discussion: The palatine tonsils and pharyngeal tonsil or adenoid are in a Waldeyer’s ring. They are thought that they work for lymphatic immune systems. However, there are several differences between tonsil and adenoid. The former has capsule, and increases their weight by growth;on the contrary the latter has no capsule, shrinks by growth. Tonsils are relatively hard mass but adenoids are very soft and easily bleed by touching with cotton swabs via nose. Conclusion: At this study, specific gravity of the adenoid was heavier than that of tonsils. These results suggest that tonsil and adenoid are physiologically different.
文摘Mathematical solutions predict abstract conditions that indicate limits or bounds for physical processes. Generally, experimental verifications and physical observations on physical processes validate the mathematical predictions. Sometimes these predictions lead to new theories and concepts that form basis of better understanding of the natural processes. Gravitational interactions between bodies are natural physical processes. A smaller body moves under the influence of gravity, due to the gravitational effect of another large body. Newton’s classical gravitational theory addresses the interactions at low velocities. Einstein’s general relativity provides firm basis for gravitational interactions. Observations over past 100 years prove the mathematical precision and predictions of general relativity. Einstein’s special relativity forms the foundation of quantum physics. In this paper, the author applies concepts of special relativity to classical two body Newtonian gravitational problem. The study predicts a new mathematically viable condition that when a body moves at a specific velocity derived in this paper, the total energy of the moving body is zero. The specific velocity is a constant. At velocities far less than specific velocity, the total energy is negative and is equal to classical value of half the potential energy. At velocities, greater the specific velocity the total energy is positive. The specific velocity condition also enables determination of specific mass of gravitating body, as well as the specific distance of the moving body from gravitating body, at which the total energy of moving body is zero.
基金supported by the Project of Stable Support for Youth Teams in Basic Research Field,Chinese Academy of Sciences(CASGrant No.YSBR-018)+2 种基金the B-type Strategic Priority Program of CAS(Grant No.XDB41000000)the National Natural Science Foundation of China(Grant No.42204165)the National Key Research and Development Program(Grant No.2022YFF0504400).
文摘In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively understood.In this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high resolution.Driven by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower altitudes.The effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the GWs.The mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their thickness.In addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.
文摘A 3D crustal model was constructed using a combination of cutting-edge techniques,which were integrated to provide a density model for Egypt and address the sporadic distribution of seismic data.These techniques include obtaining gravity data from the Gravity Field and Steady-State Ocean Circulation Explorer(GOCE),creating seismic profiles,analyzing the receiver functions of seismic data,obtaining information from boreholes,and providing geological interpretations.GOCE satellite gravity data were processed to construct a preliminary model based on nonlinear inversions of the data.A regional crustal thickness model was developed using receiver functions,seismic refraction profiles,and geological insights.The inverted model was validated using borehole data and compared with seismic estimates.The model exhibited strong consistency and revealed a correlation between crustal thickness,geology,and tectonics of Egypt.It showed that the shallowest depths of the Moho are located in the north along the Mediterranean Sea and in the eastern part along the Red Sea,reflecting an oceanic plate with a thin,high-density crust.The deepest Moho depths are located in the southwestern part of Egypt,Red Sea coastal mountains,and Sinai Peninsula.The obtained 3D model of crustal thickness provided finely detailed Moho depth estimates that aligned closely with geology and tectonic characteristics of Egypt,contributing valuable insights into the subsurface structure and tectonic processes of region.
基金Project supported by the National Natural Science Foundation of China(52104354)the National Natural Science Foundation of China(51674036)+1 种基金Joint Fund for Nuclear Technology Innovation Sponsored by the National Natural Science Foundation of Chinathe China National Nuclear Corporation(U2067201)。
文摘Comprehensive utilization of phosphogypsum(PG)has attracted much attention,especially for the recovery of rare earth elements(REEs)and gypsum due to the issues of stockpile,environmental pollution,and waste of associated resources.Traditional utilization methods suffered the issues of low REEs leaching efficiency,huge amount of CaSO_(4)saturated wastewater and high recovery cost.To solve these issues,this study investigated the occurrence of REEs in PG and the leaching of REEs.The results show that REEs in PG are in the forms of(1)REEs mineral inclusions,(2)REEs isomorphous substitution of Ca^(2+)in gypsum lattice,(3)dispersed soluble REEs salts.Acid leaching results demonstrate that(1)the dissolution of gypsum matrix is the control factor of REEs leaching;(2)H_(2)SO_(4)is a promising leachant considering the recycle of leachate;(3)the gypsum matrix suffers a recrystallization during the acid leaching and releases the soluble REEs from PG to aqueous solution.For the recovery of the undissolved REEs mineral inclusions,wet sieving concentrated 37.1 wt%of the REEs in a 10.7 wt%mass,increasing REEs content from 309 to 1071 ppm.Finally,a green process combining gravity separation and hydrometallurgy is proposed.This process owns the merits of wastewater free,considerable REEs recovery(about 10%increase compared with traditional processes),excellent gypsum purification(>95 wt%CaSO_(4)·2H_(2)O,with<0.06 wt%of soluble P_(2)O_(5) and<0.015 wt%of soluble F)and reagent saving(about 2/3less reagent consumption than non-cyclical leaching).
基金The Project Supported by National Natural Science Foundation of China and Computer Chemistry Laboratory of Chinese Academy of Sciences.
文摘A new group-contribution method involving specific gravity as a parameter is proposed for predicting criticaltemperature.Being appliable to all kinds of organic compounds,it gives an average percent deviation of 0.88%for 93 compounds and is particularly useful to those substances for which the normal boiling points are stillunknown.
基金National Key Research and Development Program of China(No.2020YFC1909202)Major Science and Technology Program of Yunnan Province,China(No.202202AB080012)for financial support。
文摘Copper and cobalt were recovered from SICOMINES mining waste rock in the Democratic Republic of Congo.The process mineralogy of the samples was analyzed using scanning electron microscopy and energy dispersive spectroscopy.The results showed that copper minerals exhibited various forms and uneven particle sizes,while cobalt existed in the form of highly dispersed asbolane,and large amounts of easily slimed gangue minerals were filled in the samples,making it difficult to separate copper and cobalt minerals.The particle size range plays a decisive role in selecting the separation method for the copper−cobalt ore.Gravity separation was suitable for particles ranging from 43 to 246μm,while flotation was more effective for particles below 43μm.After ore grinding and particle size classification,applying a combined gravity separation(shaking table)−flotation method yielded concentrated minerals with a copper recovery of 72.83%and a cobalt recovery of 31.13%.
