Spatial-temporal analysis of emotions in society has become popular in many studies integrating geography with the humanities,and has shown its influence on social sensing and geo-computation for social sciences.Emoti...Spatial-temporal analysis of emotions in society has become popular in many studies integrating geography with the humanities,and has shown its influence on social sensing and geo-computation for social sciences.Emotions in society are often volatile,irrational,and vulnerable to the social environment.A critical challenge is to analyze changes in long-term and large-scale emotions in society.In this paper,we propose exploiting this challenge by using spatial-temporal analysis.After extracting emotional,temporal,and spatial information,a spatial standardization approach based on adataset of administrative district changes addresses the problem of Chinese toponym changes.Finally,over 1.7 million news data from the People’s Daily from 1956 to 2014 were collected to explore the changes,spatial distribution,and driving factors of emotions in society using spatial-temporal analysis.The experimental results found that the spatial-temporal analysis of emotions in society in the news is consistent with the results of related sociological research.展开更多
This study has revealed spatial-temporal changes in Recreational Business Dis- tricts （RBDs） in Beijing and examined the relationship between the location of urban RBDs and traffic conditions, resident and tourist d...This study has revealed spatial-temporal changes in Recreational Business Dis- tricts （RBDs） in Beijing and examined the relationship between the location of urban RBDs and traffic conditions, resident and tourist density, scenic spots, and land prices. A more reasonable classification of urban RBDs （LSC, CPS, and ULA） is also proposed. Quantitative methods such as Gini Coefficient, Spatial Interpolation, Kernel Density Estimation, and Geographical Detector were employed to collect and analyze the data from three types of urban RBDs in Beijing in 1990, 2000, and 2014, respectively, and the spatial-temporal pat- terns as well as the distribution characteristics of urban RBDs were analyzed using ArcGIS software. It was concluded that （1） both the number and scale of urban RBDs in Beijing have been expanding and the trend for all types of urban RBDs in Beijing to be spatially agglom- erated is continuing; （2） the spatial-temporal evolution pattern of urban RBDs in Beijing is ＂single-core agglomeration-dual-core agglomeration-multi-core diffusion＂; and （3） urban RBDs were always located in areas with low traffic density, tourist attractions, high resident and tourist population density, and relatively high land valuations; these factors also affect the scale size of RBDs.展开更多
Urban air pollution is a prominent problem related to the urban development in China, especially in the densely populated urban agglomerations. Therefore, scientific examination of regional variation of air quality an...Urban air pollution is a prominent problem related to the urban development in China, especially in the densely populated urban agglomerations. Therefore, scientific examination of regional variation of air quality and its dominant factors is of great importance to regional environmental management. In contrast to traditional air pollution researches which only concentrate on a single year or a single pollutant, this paper analyses spatiotemporal patterns and determinants of air quality in disparate regions based on the air quality index(AQI) of the Yangtze River Delta region(YRD) of China from 2014 to 2016. Results show that the annual average value of the AQI in the YRD region decreases from 2014 to 2016 and exhibit a basic characteristic of ‘higher in winter, lower in summer and slightly high in spring and autumn'. The attainment rate of the AQI shows an apparently spatial stratified heterogeneity, Hefei metropolitan area and Nanjing metropolitan area keeping the worst air quality. The frequency of air pollution occurring in large regions was gradually decreasing during the study period. Drawing from entropy method analysis, industrialization and urbanization represented by per capita GDP and total energy consumption were the most important factors. Furthermore, population agglomeration is a factor that cannot be ignored especially in some mega-cities. Limited to data collection, more research is needed to gain insight into the spatiotemporal pattern and influence mechanism in the future.展开更多
The influence of anthropogenic activities,especially artificial dykes,on the coastal wetland landscape is now considered as a serious problem to the coastal ecosystem.It is important and necessary to analyze changes o...The influence of anthropogenic activities,especially artificial dykes,on the coastal wetland landscape is now considered as a serious problem to the coastal ecosystem.It is important and necessary to analyze changes of coastal landscape pattern under the influence of artificial dykes for the protection and management of coastal wetland.Our study aimed to reveal the quantitative characteristics of the coastal wetland landscape and its spatial-temporal dynamics under the influence of artificial dykes in the Yellow River delta(YRD).It was analyzed by the methods of the statistical analysis of landscape structure,five selected landscape indices and the changes of spatial centroids of three typical wetland types,including reed marshes,tidal fiats and aquaculture-salt fields.The results showed that:(1)Reduction of wetland area,especially the degradation of natural wetlands,had been the principal problem since the dykes were constructed in the YRD.The dykes created conditions for the development of artificial wetlands.However,the new born artificial wetlands were still less than the vanished natural wetlands.(2)Compared with the open area,the building of artificial dykes significantly speeded up the changes of landscape patterns and the aggravation of the landscape fragmentation in the closed area.(3)The changes of area-weighted centroids of three typical wetland landscapes were greatly affected by dykes,and the movement of the centroid of the aquaculture-salt field was very sensitive to the dykes constructed in the corresponding period.展开更多
Based on RS and GIS methods, land use information for 1985 and 1995 was acquired from TM images and analyzed. Then on both spatial and temporal aspects, this paper analyzes land use change in three provinces of Hebei,...Based on RS and GIS methods, land use information for 1985 and 1995 was acquired from TM images and analyzed. Then on both spatial and temporal aspects, this paper analyzes land use change in three provinces of Hebei, Shandong and Liaoning and two municipalities of Beijing and Tianjin in the Bohai Rim covering the period of 1985 to 1995. The extent, rate, areal difference and trend of various types of land use changes in the region, as well as spatial changes of major types of land use, their distribution characteristics and regional orientation are revealed. The regional characteristics of land use are elaborated, so as to provide effective policy support for sustainable land use in the area around the Bohai Bay.展开更多
Comprehensive study on land-use change of spatial pattern and temporal process is the key component in land use/land cover changes (LUCC) study nowadays. According to the theories and methods of Geo-information Tupu (...Comprehensive study on land-use change of spatial pattern and temporal process is the key component in land use/land cover changes (LUCC) study nowadays. According to the theories and methods of Geo-information Tupu (Carto-methodology in Geo-information, CMGI) for geospatial and temporal analysis and integration models of spatial pattern and temporal processes in GIS, the paper puts forward Tupu methodology of land-use change and names the basic synthetic unit of spatial-temporal information Tupu unit. Tupu unit is the synthetic unit for geospatial-temporal analysis, which is synthesized by “space·attribute·process”features and composed of relatively homogeneous geographic unit and temporal unit. Based on the spatial features of 4 stages of land-use change in 1956, 1984, 1991, and 1996, a series of Tupu on land-use change in the Yellow River Delta (YRD) are created and studied in the paper, which includes 3 temporal units of spatial-temporal Tupu, process Tupu of land-use changes during the last 40 years, and reconstructions of a series of “arisen”Tupu, “arisen”process Tupu and pattern Tupu on land-use changes in the last 40 years by remapping tables of a reclassifying system. There are 3 methods of Tupu analysis on land-use change that are used to disclose change processes of land-use spatial conversion in YRD, such as spatial query and statistics, order of Tupu units by area and land-use conversion matrixes. In order to reveal the spatial pattern of land-use change processes, we analyze spatial-temporal changes of each Tupu above in various temporal units and spatial difference of pattern Tupu in the last 40 years by dynamic Tupu units. Tupu analysis on regional land-use is a promising trial on the comprehensive research of “spatial pattern of dynamic process”and “temporal process of spatial pattern”in LUCC research. The geo-information Tupu methodology would be a powerful and efficient tool on integrated studies of spatial pattern and temporal process in geoscience.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
The goal of this study was to determine the spatiotemporal characteristics of mangrove distribution and fragmentation patterns from 1988 through 2019 in Dongzhaigang.Land cover datasets were generated for Dongzhaigang...The goal of this study was to determine the spatiotemporal characteristics of mangrove distribution and fragmentation patterns from 1988 through 2019 in Dongzhaigang.Land cover datasets were generated for Dongzhaigang for multiple years via a decision tree method based on a classification and regression tree(CART)algorithm using Landsat time series images.Spatiotemporal transform and fragmentation patterns of mangrove distribution were separately assessed with a transfer matrix of land cover types and a landscape pattern index.The classification method combined with multi-band images showed good accuracy,with overall accuracy higher than 90%.Mangrove areas in 1988,1999,2009,and 2019 were 2050,1875,1818,and 1750 ha,respectively,with decreases mainly due to conversion to aquaculture ponds and farmland.A mangrove growth index(MGI)was proposed,reflecting the water-mangrove relationship,showing positive mangrove growth from 1988–2009 and negative growth from 2009–2019.Study results indicated anthropogenic factors play a leading role in the extent and scale of mangrove effects over the past 30 years.According to the analysis results,corresponding management and protection measures are proposed to provide reference for the sustainable development of Dongzhaigang Mangrove Wetland ecosystem.展开更多
Transit managers can use Intelligent Transportation System technologies to access large amounts of data to monitor network status.However,the presentation of the data lacks structural information.Existing single-netwo...Transit managers can use Intelligent Transportation System technologies to access large amounts of data to monitor network status.However,the presentation of the data lacks structural information.Existing single-network description technologies are ineffective in representing the temporal and spatial characteristics simultaneously.Therefore,there is a need for complementary methods to address these deficiencies.To address these limitations,this paper proposes an approach that combines Network Snapshots and Temporal Paths for the scheduled system.A dual information network is constructed to assess the degree of operational deviation considering the planning tasks.To validate the effectiveness,discussions are conducted through a modified cosine similarity calculation on theoretical analysis,delay level description,and the ability to identify abnormal dates.Compared to some state-of-the-art methods,the proposed method achieves an average Spearman delay correlation of 0.847 and a relative distance of 3.477.Furthermore,case analyses are invested in regions of China's Mainland,Europe,and the United States,investigating both the overall and sub-regional network fluctuations.To represent the impact of network fluctuations in sub-regions,a response loss value was developed.The times that are prone to fluctuations are also discussed through the classification of time series data.The research can offer a novel approach to system monitoring,providing a research direction that utilizes individual data combined to represent macroscopic states.Our code will be released at https://github.com/daozhong/STPN.git.展开更多
The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recogni...The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recognized to be limited at data boundaries and high frequencies,which can significantly reduce the signal-to-noise ratio(SNR).To solve this problem,a novel method synergistically integrating Principal Component Analysis(PCA)with SG filtering is proposed in this paper.This approach avoids the is-sue of excessive smoothing associated with larger window sizes.The proposed PCA-SG filtering algorithm was applied to a CO gas sensing system based on Cavity Ring-Down Spectroscopy(CRDS).The perform-ance of the PCA-SG filtering algorithm is demonstrated through comparison with Moving Average Filtering(MAF),Wavelet Transformation(WT),Kalman Filtering(KF),and the SG filter.The results demonstrate that the proposed algorithm exhibits superior noise reduction capabilities compared to the other algorithms evaluated.The SNR of the ring-down signal was improved from 11.8612 dB to 29.0913 dB,and the stand-ard deviation of the extracted ring-down time constant was reduced from 0.037μs to 0.018μs.These results confirm that the proposed PCA-SG filtering algorithm effectively improves the smoothness of the ring-down curve data,demonstrating its feasibility.展开更多
Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adj...Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adjusted life years(DALYs),stratified by age,sex,and economic development level based on data retrieved from the Global Burden of Disease study 2021.Decomposition and frontier analyses were employed to identify key drivers of burden variation and visualize potential reductions based on development levels.Results:Between 1990 and 2021,the global burden of ARIs showed a significant decline in both achievable age-standardized DALYs rate and age-standardized mortality rates(EAPC=-3.87 and-3.81,respectively).Different age groups and sex witnessed different levels of ARI burden,males experienced heavier burden than females and the 0-4 years-old group experienced heavier burden than other study age groups.Most of the 204 countries and territories experienced a downward trend of ARI burden,with slight increases observed only in Lesotho and Dominica.A negative correlation was found between the Socio-demographic Index and ARI burden.Decomposition analysis indicated that the significant decreases in deaths and DALYs were primarily driven by epidemiological changes.Conclusions:The global burden of ARIs among children and adolescents has declined over the past three decades,but substantial regional disparities persist.Targeted public health strategies are needed to address the continued ARI burden in high-risk regions and vulnerable age groups.展开更多
The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial in...The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.展开更多
Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study ...Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study revealed that removing bags from‘Gengcunyangtao’red-fleshed peach fruits triggers the rapid and uniform accumulation of anthocyanins in the flesh,resulting in anthocyanin levels that exceed those in unbagged fruits.The exposure to light after bag removal triggered significant increases in anthocyanin levels within 24 h.This was accompanied by the rapid upregulation of light-responsive and flavonoid biosynthetic gene expression levels within 6 h.A metabolomic analysis indicated that anthocyanin precursors,especially p-coumaric acid,accumulated before bag removal,thereby increasing substrate availability for rapid anthocyanin synthesis.On the basis of a weighted gene co-expression network analysis,MYB transcription factors,anthocyanin transporters,glutathione S-transferase,and multidrug and toxic compound extrusion(MATE)were identified as key regulators that coordinate precursor storage along with light-induced transcriptional activation.Notably,PpMYB4 binds to the promoter of PpGSTF14 and activates its expression,thereby promoting anthocyanin accumulation.The study findings elucidated the temporal coordination of metabolic priming and light-responsive transcriptional regulation driving rapid anthocyanin biosynthesis,with possible implications for improving peach fruit flesh coloration.展开更多
Dianthus spiculifolius Schur,as an emerging ornamental plant,has extensive applications and economic values.In this study,the DsCBL4 gene was successfully cloned,and its tissue-specific expression,expression patterns ...Dianthus spiculifolius Schur,as an emerging ornamental plant,has extensive applications and economic values.In this study,the DsCBL4 gene was successfully cloned,and its tissue-specific expression,expression patterns under various abiotic stresses,subcellular localization,and bioinformatics analysis of the encoded amino acid sequence were conducted.The results showed that the coding region of the DsCBL4 gene was 675 bp long,encoding 224 amino acids.It had high homology with the amino acids encoded by Amaranthus tricolor,Chenopodium quinoa and Spinacia oleracea.The predicted relative molecular mass of DsCBL4 was 25.61 ku,with an isoelectric point of 4.58,and it had phosphorylation sites,belonging to an unstable hydrophilic protein.Its secondary structure includedα-helices,irregular coils and extended chains.The tertiary structure prediction revealed that DsCBL4 had four EFhand calcium-binding domains necessary for Ca2+binding in plant calmodulin-like proteins and the FPSF motif for calcineurin B-like protein(CBL)-interacting protein kinase(CIPK)activation.The expression level of the DsCBL4 gene showed tissue specificity,with the highest expression in roots.It was induced by drought,low temperature,combined drought and low temperature,salt stress,nitrogen stress,phosphorus stress,calcium ion stress,high temperature stress,and abscisic acid(ABA)stress.Both transient infection in Nicotiana tabacum L.and stable expression in transgenic Arabidopsis thaliana showed that the DsCBL4 protein was localized to the cell membrane.These results suggested that DsCBL4 might be involved in the abiotic stress response of Dianthus spiculifolius through the calcium signaling pathway,providing a theoretical basis for understanding its molecular mechanism.This study provided an important reference for further exploring the role of the DsCBLs gene family in plant stress resistance.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
[Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical sim...[Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical simulations and dynamic analysis methods,this study systematically investigates the coupled dynamic response characteristics during the cage-carrier vessel separation process to reveal its dynamic evolution patterns and key influence mechanisms.[Method]Based on potential flow theory,a fully coupled dynamic analysis model of crane vessel-net cage-semi-submersible barge was established for a marine ranch project in Guangdong.The complete lifting process was dynamically simulated using SESAM software.Five typical operating sea states were configured to investigate the influence of wave parameters on the system's motion response under combined wave-current-wind actions.[Result]The results demonstrate that wave period dominates the system stability.Under short-period conditions,the system maintains stable motion with relatively small horizontal relative displacements,while long-period conditions excite low-frequency resonance,leading to significant slow-drift motions.Vertical response analysis reveals that long-period waves cause severe relative displacement fluctuations between the cage and semi-submersible vessel,with actual displacement amplitudes doubling the preset safety target of 2.045 m.Quantitative analysis further indicates that when significant wave height increases from 1.0 m to 1.5 m,the actual displacement amplitude increases by approximately 20%relative to the target displacement of 2.045 m,demonstrating that its influence is significantly weaker than the displacement variations induced by wave period changes.The complete dynamic simulation successfully captures the continuous dynamic response characteristics during the lifting process.[Conclusion]This research clarifies the influence mechanisms of wave parameters on the cage lifting process,identifying wave period as the crucial factor for operational safety.An operation window assessment method incorporating multi-body coupling effects is established,proposing a safety criterion with peak period not exceeding six seconds as the core requirement.The findings provide theoretical foundation for safe installation of marine ranch net cages and offer valuable references for similar offshore lifting operations.展开更多
Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China Un...Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China University of Technology,Guangzhou 510006,China The authors regret that the published version of this article contained several errors and omissions,which are described and corrected below.1.Figs.3 and 4(figure order and legends).In the published article,Figs.3 and 4 were inadvertently published in reversed order.The figures should be swapped so that the figure content matches its caption.The correct figures and their legends are provided on the following page.2.Title correction.The compound name in the published title was incorrectly typeset as“benzo[a]pyrene”The correct spelling is“benzo[a]pyrene.”3.Text corrections in Section 2.4.Several typographical errors occurred in Section 2.4(“Up-regulation of acetoin,lactate,and kanosamine biosynthesis under sodium gluconate treatment”).展开更多
Correction to:Nuclear Science and Techniques(2025)36:111 https://doi.org/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have ...Correction to:Nuclear Science and Techniques(2025)36:111 https://doi.org/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have read‘SCRs’.In Table 7 of this article,the column header ρ_fuel was incorrect and should have read CPv_fuel.For completeness and transparency,the old incorrect version and the corrected version of Table 7 are displayed below.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
基金National Natural Science Foundation of China(No.41971337)。
文摘Spatial-temporal analysis of emotions in society has become popular in many studies integrating geography with the humanities,and has shown its influence on social sensing and geo-computation for social sciences.Emotions in society are often volatile,irrational,and vulnerable to the social environment.A critical challenge is to analyze changes in long-term and large-scale emotions in society.In this paper,we propose exploiting this challenge by using spatial-temporal analysis.After extracting emotional,temporal,and spatial information,a spatial standardization approach based on adataset of administrative district changes addresses the problem of Chinese toponym changes.Finally,over 1.7 million news data from the People’s Daily from 1956 to 2014 were collected to explore the changes,spatial distribution,and driving factors of emotions in society using spatial-temporal analysis.The experimental results found that the spatial-temporal analysis of emotions in society in the news is consistent with the results of related sociological research.
基金Foundation： National Natural Science Foundation of China, No.41071110
文摘This study has revealed spatial-temporal changes in Recreational Business Dis- tricts （RBDs） in Beijing and examined the relationship between the location of urban RBDs and traffic conditions, resident and tourist density, scenic spots, and land prices. A more reasonable classification of urban RBDs （LSC, CPS, and ULA） is also proposed. Quantitative methods such as Gini Coefficient, Spatial Interpolation, Kernel Density Estimation, and Geographical Detector were employed to collect and analyze the data from three types of urban RBDs in Beijing in 1990, 2000, and 2014, respectively, and the spatial-temporal pat- terns as well as the distribution characteristics of urban RBDs were analyzed using ArcGIS software. It was concluded that （1） both the number and scale of urban RBDs in Beijing have been expanding and the trend for all types of urban RBDs in Beijing to be spatially agglom- erated is continuing; （2） the spatial-temporal evolution pattern of urban RBDs in Beijing is ＂single-core agglomeration-dual-core agglomeration-multi-core diffusion＂; and （3） urban RBDs were always located in areas with low traffic density, tourist attractions, high resident and tourist population density, and relatively high land valuations; these factors also affect the scale size of RBDs.
基金Under the auspices of Key Projects of the National Social Science Fund(No.16AJL015)Youth Project of Natural Science Foundation of Jiangsu Province(No.BK20170440)+1 种基金Open Foundation of Key Laboratory of Watershed Geographical Science(No.WSGS2017004)Project of Nantong Key Laboratory(No.CP12016005)
文摘Urban air pollution is a prominent problem related to the urban development in China, especially in the densely populated urban agglomerations. Therefore, scientific examination of regional variation of air quality and its dominant factors is of great importance to regional environmental management. In contrast to traditional air pollution researches which only concentrate on a single year or a single pollutant, this paper analyses spatiotemporal patterns and determinants of air quality in disparate regions based on the air quality index(AQI) of the Yangtze River Delta region(YRD) of China from 2014 to 2016. Results show that the annual average value of the AQI in the YRD region decreases from 2014 to 2016 and exhibit a basic characteristic of ‘higher in winter, lower in summer and slightly high in spring and autumn'. The attainment rate of the AQI shows an apparently spatial stratified heterogeneity, Hefei metropolitan area and Nanjing metropolitan area keeping the worst air quality. The frequency of air pollution occurring in large regions was gradually decreasing during the study period. Drawing from entropy method analysis, industrialization and urbanization represented by per capita GDP and total energy consumption were the most important factors. Furthermore, population agglomeration is a factor that cannot be ignored especially in some mega-cities. Limited to data collection, more research is needed to gain insight into the spatiotemporal pattern and influence mechanism in the future.
基金supported by the Open Fund for Field Stations of Institute of Geographic Sciences and Natural Resources Research,CAS and the Ocean Public Welfare Scientific Research Project(Grant No.201105020)
文摘The influence of anthropogenic activities,especially artificial dykes,on the coastal wetland landscape is now considered as a serious problem to the coastal ecosystem.It is important and necessary to analyze changes of coastal landscape pattern under the influence of artificial dykes for the protection and management of coastal wetland.Our study aimed to reveal the quantitative characteristics of the coastal wetland landscape and its spatial-temporal dynamics under the influence of artificial dykes in the Yellow River delta(YRD).It was analyzed by the methods of the statistical analysis of landscape structure,five selected landscape indices and the changes of spatial centroids of three typical wetland types,including reed marshes,tidal fiats and aquaculture-salt fields.The results showed that:(1)Reduction of wetland area,especially the degradation of natural wetlands,had been the principal problem since the dykes were constructed in the YRD.The dykes created conditions for the development of artificial wetlands.However,the new born artificial wetlands were still less than the vanished natural wetlands.(2)Compared with the open area,the building of artificial dykes significantly speeded up the changes of landscape patterns and the aggravation of the landscape fragmentation in the closed area.(3)The changes of area-weighted centroids of three typical wetland landscapes were greatly affected by dykes,and the movement of the centroid of the aquaculture-salt field was very sensitive to the dykes constructed in the corresponding period.
基金National Natural Science Foundation of China, No.49831020.
文摘Based on RS and GIS methods, land use information for 1985 and 1995 was acquired from TM images and analyzed. Then on both spatial and temporal aspects, this paper analyzes land use change in three provinces of Hebei, Shandong and Liaoning and two municipalities of Beijing and Tianjin in the Bohai Rim covering the period of 1985 to 1995. The extent, rate, areal difference and trend of various types of land use changes in the region, as well as spatial changes of major types of land use, their distribution characteristics and regional orientation are revealed. The regional characteristics of land use are elaborated, so as to provide effective policy support for sustainable land use in the area around the Bohai Bay.
基金supported by the National Natural Science Foundation of China(40371093)the Special Funds for Major State Basic Research Project(G20000779,2002CB412408)+2 种基金Opening Fund projects of State Key Laboratory of Remote Sensing Science in the Institute of Remote Sensing Applications(SK040006)Opening Fund projects of State Key Laboratory of Estuarine and Coastal Research of East China Normal University,China Postdoctoral Science Foundationthe Project from'863'Marine Monitor of Hi-Tech Research and Development Program of China(2001AA633010).
文摘Comprehensive study on land-use change of spatial pattern and temporal process is the key component in land use/land cover changes (LUCC) study nowadays. According to the theories and methods of Geo-information Tupu (Carto-methodology in Geo-information, CMGI) for geospatial and temporal analysis and integration models of spatial pattern and temporal processes in GIS, the paper puts forward Tupu methodology of land-use change and names the basic synthetic unit of spatial-temporal information Tupu unit. Tupu unit is the synthetic unit for geospatial-temporal analysis, which is synthesized by “space·attribute·process”features and composed of relatively homogeneous geographic unit and temporal unit. Based on the spatial features of 4 stages of land-use change in 1956, 1984, 1991, and 1996, a series of Tupu on land-use change in the Yellow River Delta (YRD) are created and studied in the paper, which includes 3 temporal units of spatial-temporal Tupu, process Tupu of land-use changes during the last 40 years, and reconstructions of a series of “arisen”Tupu, “arisen”process Tupu and pattern Tupu on land-use changes in the last 40 years by remapping tables of a reclassifying system. There are 3 methods of Tupu analysis on land-use change that are used to disclose change processes of land-use spatial conversion in YRD, such as spatial query and statistics, order of Tupu units by area and land-use conversion matrixes. In order to reveal the spatial pattern of land-use change processes, we analyze spatial-temporal changes of each Tupu above in various temporal units and spatial difference of pattern Tupu in the last 40 years by dynamic Tupu units. Tupu analysis on regional land-use is a promising trial on the comprehensive research of “spatial pattern of dynamic process”and “temporal process of spatial pattern”in LUCC research. The geo-information Tupu methodology would be a powerful and efficient tool on integrated studies of spatial pattern and temporal process in geoscience.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金financially supported by the National Natural Science Foundation of China(Nos.U2244225 and 42020104005)the Ministry of Education of China(111 Project)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)and China Geological Survey(No.DD20211391)。
文摘The goal of this study was to determine the spatiotemporal characteristics of mangrove distribution and fragmentation patterns from 1988 through 2019 in Dongzhaigang.Land cover datasets were generated for Dongzhaigang for multiple years via a decision tree method based on a classification and regression tree(CART)algorithm using Landsat time series images.Spatiotemporal transform and fragmentation patterns of mangrove distribution were separately assessed with a transfer matrix of land cover types and a landscape pattern index.The classification method combined with multi-band images showed good accuracy,with overall accuracy higher than 90%.Mangrove areas in 1988,1999,2009,and 2019 were 2050,1875,1818,and 1750 ha,respectively,with decreases mainly due to conversion to aquaculture ponds and farmland.A mangrove growth index(MGI)was proposed,reflecting the water-mangrove relationship,showing positive mangrove growth from 1988–2009 and negative growth from 2009–2019.Study results indicated anthropogenic factors play a leading role in the extent and scale of mangrove effects over the past 30 years.According to the analysis results,corresponding management and protection measures are proposed to provide reference for the sustainable development of Dongzhaigang Mangrove Wetland ecosystem.
文摘Transit managers can use Intelligent Transportation System technologies to access large amounts of data to monitor network status.However,the presentation of the data lacks structural information.Existing single-network description technologies are ineffective in representing the temporal and spatial characteristics simultaneously.Therefore,there is a need for complementary methods to address these deficiencies.To address these limitations,this paper proposes an approach that combines Network Snapshots and Temporal Paths for the scheduled system.A dual information network is constructed to assess the degree of operational deviation considering the planning tasks.To validate the effectiveness,discussions are conducted through a modified cosine similarity calculation on theoretical analysis,delay level description,and the ability to identify abnormal dates.Compared to some state-of-the-art methods,the proposed method achieves an average Spearman delay correlation of 0.847 and a relative distance of 3.477.Furthermore,case analyses are invested in regions of China's Mainland,Europe,and the United States,investigating both the overall and sub-regional network fluctuations.To represent the impact of network fluctuations in sub-regions,a response loss value was developed.The times that are prone to fluctuations are also discussed through the classification of time series data.The research can offer a novel approach to system monitoring,providing a research direction that utilizes individual data combined to represent macroscopic states.Our code will be released at https://github.com/daozhong/STPN.git.
文摘The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recognized to be limited at data boundaries and high frequencies,which can significantly reduce the signal-to-noise ratio(SNR).To solve this problem,a novel method synergistically integrating Principal Component Analysis(PCA)with SG filtering is proposed in this paper.This approach avoids the is-sue of excessive smoothing associated with larger window sizes.The proposed PCA-SG filtering algorithm was applied to a CO gas sensing system based on Cavity Ring-Down Spectroscopy(CRDS).The perform-ance of the PCA-SG filtering algorithm is demonstrated through comparison with Moving Average Filtering(MAF),Wavelet Transformation(WT),Kalman Filtering(KF),and the SG filter.The results demonstrate that the proposed algorithm exhibits superior noise reduction capabilities compared to the other algorithms evaluated.The SNR of the ring-down signal was improved from 11.8612 dB to 29.0913 dB,and the stand-ard deviation of the extracted ring-down time constant was reduced from 0.037μs to 0.018μs.These results confirm that the proposed PCA-SG filtering algorithm effectively improves the smoothness of the ring-down curve data,demonstrating its feasibility.
文摘Objective:To evaluate the global,regional,and national burden and determinants of Acute Respiratory Infections(ARIs)among children and adolescents from 1990 to 2021.Methods:We analysed ARI mortality and disability-adjusted life years(DALYs),stratified by age,sex,and economic development level based on data retrieved from the Global Burden of Disease study 2021.Decomposition and frontier analyses were employed to identify key drivers of burden variation and visualize potential reductions based on development levels.Results:Between 1990 and 2021,the global burden of ARIs showed a significant decline in both achievable age-standardized DALYs rate and age-standardized mortality rates(EAPC=-3.87 and-3.81,respectively).Different age groups and sex witnessed different levels of ARI burden,males experienced heavier burden than females and the 0-4 years-old group experienced heavier burden than other study age groups.Most of the 204 countries and territories experienced a downward trend of ARI burden,with slight increases observed only in Lesotho and Dominica.A negative correlation was found between the Socio-demographic Index and ARI burden.Decomposition analysis indicated that the significant decreases in deaths and DALYs were primarily driven by epidemiological changes.Conclusions:The global burden of ARIs among children and adolescents has declined over the past three decades,but substantial regional disparities persist.Targeted public health strategies are needed to address the continued ARI burden in high-risk regions and vulnerable age groups.
基金support from the National Key Research and Development Program of China(No.2024YFB3713705)is acknowledgedWangzhong Mu would like to acknowledge the Strategic Mobility,Sweden(SSF,No.SM22-0039)+1 种基金the Swedish Foundation for International Cooperation in Research and Higher Education(STINT,No.IB2022-9228)the Jernkontoret(Sweden)for supporting this clean steel research.Gonghao Lian would like to acknowledge China Scholarship Council(CSC,No.202306080032).
文摘The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective.
基金supported by the Key Scientific and Technological Grant of Zhejiang for Breeding New Agricultural Varieties(Grant No.2021C12066-4)Huzhou Agricultural Science and Technology Innovation Team Project(Grant No.2022HN01).
文摘Red-fleshed fruits are valued for their vibrant color and high anthocyanin content.Pre-harvest fruit bagging enhances fruit peel pigmentation,but its effect on flesh coloration remains poorly characterized.This study revealed that removing bags from‘Gengcunyangtao’red-fleshed peach fruits triggers the rapid and uniform accumulation of anthocyanins in the flesh,resulting in anthocyanin levels that exceed those in unbagged fruits.The exposure to light after bag removal triggered significant increases in anthocyanin levels within 24 h.This was accompanied by the rapid upregulation of light-responsive and flavonoid biosynthetic gene expression levels within 6 h.A metabolomic analysis indicated that anthocyanin precursors,especially p-coumaric acid,accumulated before bag removal,thereby increasing substrate availability for rapid anthocyanin synthesis.On the basis of a weighted gene co-expression network analysis,MYB transcription factors,anthocyanin transporters,glutathione S-transferase,and multidrug and toxic compound extrusion(MATE)were identified as key regulators that coordinate precursor storage along with light-induced transcriptional activation.Notably,PpMYB4 binds to the promoter of PpGSTF14 and activates its expression,thereby promoting anthocyanin accumulation.The study findings elucidated the temporal coordination of metabolic priming and light-responsive transcriptional regulation driving rapid anthocyanin biosynthesis,with possible implications for improving peach fruit flesh coloration.
基金Supported by the National Key R&D Program(2022YFF1300500)the Spring Goose Support Program(CYQN24018)the National Natural Science Foundation of China(32572123)。
文摘Dianthus spiculifolius Schur,as an emerging ornamental plant,has extensive applications and economic values.In this study,the DsCBL4 gene was successfully cloned,and its tissue-specific expression,expression patterns under various abiotic stresses,subcellular localization,and bioinformatics analysis of the encoded amino acid sequence were conducted.The results showed that the coding region of the DsCBL4 gene was 675 bp long,encoding 224 amino acids.It had high homology with the amino acids encoded by Amaranthus tricolor,Chenopodium quinoa and Spinacia oleracea.The predicted relative molecular mass of DsCBL4 was 25.61 ku,with an isoelectric point of 4.58,and it had phosphorylation sites,belonging to an unstable hydrophilic protein.Its secondary structure includedα-helices,irregular coils and extended chains.The tertiary structure prediction revealed that DsCBL4 had four EFhand calcium-binding domains necessary for Ca2+binding in plant calmodulin-like proteins and the FPSF motif for calcineurin B-like protein(CBL)-interacting protein kinase(CIPK)activation.The expression level of the DsCBL4 gene showed tissue specificity,with the highest expression in roots.It was induced by drought,low temperature,combined drought and low temperature,salt stress,nitrogen stress,phosphorus stress,calcium ion stress,high temperature stress,and abscisic acid(ABA)stress.Both transient infection in Nicotiana tabacum L.and stable expression in transgenic Arabidopsis thaliana showed that the DsCBL4 protein was localized to the cell membrane.These results suggested that DsCBL4 might be involved in the abiotic stress response of Dianthus spiculifolius through the calcium signaling pathway,providing a theoretical basis for understanding its molecular mechanism.This study provided an important reference for further exploring the role of the DsCBLs gene family in plant stress resistance.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
文摘[Objective]This study aims to investigate the multi-body hydrodynamic interaction mechanisms during offshore lifting operations of aquaculture net cages in wind-fishery integration systems.By integrating numerical simulations and dynamic analysis methods,this study systematically investigates the coupled dynamic response characteristics during the cage-carrier vessel separation process to reveal its dynamic evolution patterns and key influence mechanisms.[Method]Based on potential flow theory,a fully coupled dynamic analysis model of crane vessel-net cage-semi-submersible barge was established for a marine ranch project in Guangdong.The complete lifting process was dynamically simulated using SESAM software.Five typical operating sea states were configured to investigate the influence of wave parameters on the system's motion response under combined wave-current-wind actions.[Result]The results demonstrate that wave period dominates the system stability.Under short-period conditions,the system maintains stable motion with relatively small horizontal relative displacements,while long-period conditions excite low-frequency resonance,leading to significant slow-drift motions.Vertical response analysis reveals that long-period waves cause severe relative displacement fluctuations between the cage and semi-submersible vessel,with actual displacement amplitudes doubling the preset safety target of 2.045 m.Quantitative analysis further indicates that when significant wave height increases from 1.0 m to 1.5 m,the actual displacement amplitude increases by approximately 20%relative to the target displacement of 2.045 m,demonstrating that its influence is significantly weaker than the displacement variations induced by wave period changes.The complete dynamic simulation successfully captures the continuous dynamic response characteristics during the lifting process.[Conclusion]This research clarifies the influence mechanisms of wave parameters on the cage lifting process,identifying wave period as the crucial factor for operational safety.An operation window assessment method incorporating multi-body coupling effects is established,proposing a safety criterion with peak period not exceeding six seconds as the core requirement.The findings provide theoretical foundation for safe installation of marine ranch net cages and offer valuable references for similar offshore lifting operations.
文摘Rui Chena,b,Tangbing Cui a,b,∗a School of Biology and Biological Engineering,South China University of Technology,Guangzhou 510006,China b Guangdong Key Laboratory of Fermentation and Enzyme Engineering,South China University of Technology,Guangzhou 510006,China The authors regret that the published version of this article contained several errors and omissions,which are described and corrected below.1.Figs.3 and 4(figure order and legends).In the published article,Figs.3 and 4 were inadvertently published in reversed order.The figures should be swapped so that the figure content matches its caption.The correct figures and their legends are provided on the following page.2.Title correction.The compound name in the published title was incorrectly typeset as“benzo[a]pyrene”The correct spelling is“benzo[a]pyrene.”3.Text corrections in Section 2.4.Several typographical errors occurred in Section 2.4(“Up-regulation of acetoin,lactate,and kanosamine biosynthesis under sodium gluconate treatment”).
文摘Correction to:Nuclear Science and Techniques(2025)36:111 https://doi.org/10.1007/s41365-025-01681-9.In the sentence beginning‘The weights of the parameters used for the…’in this article,the text‘RCSs’should have read‘SCRs’.In Table 7 of this article,the column header ρ_fuel was incorrect and should have read CPv_fuel.For completeness and transparency,the old incorrect version and the corrected version of Table 7 are displayed below.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
