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Mixed Local and Nonlocal Elliptic Problem with Concave-Convex and Discontinuous Nonlinearities
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作者 Yiru WANG Shuibo HUANG Qiaoyu TIAN 《Journal of Mathematical Research with Applications》 2026年第1期40-56,共17页
This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x... This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x∈R^(N)\Ω,where Ω ⊂R^(N)(N>2)is a bounded domain,μ≥0 and λ>0 are real parameters,H denotes the Heaviside function(H(t)=0 for t<0,H(t)=1 for t>0),and the mixed local and nolocal operator is defined as L(u)=−Δu+(−Δ)^(s)u with(−Δ)^(s) being the restricted fractional Laplace(0<s<1).The exponents satisfy 1<q<2<p.By employing a novel non-smooth variational principle,we establish the existence of an M-solution for this problem and identify a range for the exponent p. 展开更多
关键词 mixed local and nonlocal operator discontinuous non-smooth variational principle M-solution
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Neural boundary shape functions in physics-informed neural networks for discontinuous and high-frequency problems
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作者 P.T.NGUYEN K.A.LUONG J.H.LEE 《Applied Mathematics and Mechanics(English Edition)》 2026年第2期423-442,共20页
Physics-informed neural networks(PINNs)have been shown as powerful tools for solving partial differential equations(PDEs)by embedding physical laws into the network training.Despite their remarkable results,complicate... Physics-informed neural networks(PINNs)have been shown as powerful tools for solving partial differential equations(PDEs)by embedding physical laws into the network training.Despite their remarkable results,complicated problems such as irregular boundary conditions(BCs)and discontinuous or high-frequency behaviors remain persistent challenges for PINNs.For these reasons,we propose a novel two-phase framework,where a neural network is first trained to represent shape functions that can capture the irregularity of BCs in the first phase,and then these neural network-based shape functions are used to construct boundary shape functions(BSFs)that exactly satisfy both essential and natural BCs in PINNs in the second phase.This scheme is integrated into both the strong-form and energy PINN approaches,thereby improving the quality of solution prediction in the cases of irregular BCs.In addition,this study examines the benefits and limitations of these approaches in handling discontinuous and high-frequency problems.Overall,our method offers a unified and flexible solution framework that addresses key limitations of existing PINN methods with higher accuracy and stability for general PDE problems in solid mechanics. 展开更多
关键词 physics-informed neural network(PINN) boundary shape function(BSF) strong-form approach energy approach discontinuITY high-frequency problem
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An extended discontinuous deformation analysis for simulation of grouting reinforcement in a water-rich fractured rock tunnel 被引量:3
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作者 Jingyao Gao Siyu Peng +1 位作者 Guangqi Chen Hongyun Fan 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第1期168-186,共19页
Grouting has been the most effective approach to mitigate water inrush disasters in underground engineering due to its ability to plug groundwater and enhance rock strength.Nevertheless,there is a lack of potent numer... Grouting has been the most effective approach to mitigate water inrush disasters in underground engineering due to its ability to plug groundwater and enhance rock strength.Nevertheless,there is a lack of potent numerical tools for assessing the grouting effectiveness in water-rich fractured strata.In this study,the hydro-mechanical coupled discontinuous deformation analysis(HM-DDA)is inaugurally extended to simulate the grouting process in a water-rich discrete fracture network(DFN),including the slurry migration,fracture dilation,water plugging in a seepage field,and joint reinforcement after coagulation.To validate the capabilities of the developed method,several numerical examples are conducted incorporating the Newtonian fluid and Bingham slurry.The simulation results closely align with the analytical solutions.Additionally,a set of compression tests is conducted on the fresh and grouted rock specimens to verify the reinforcement method and calibrate the rational properties of reinforced joints.An engineering-scale model based on a real water inrush case of the Yonglian tunnel in a water-rich fractured zone has been established.The model demonstrates the effectiveness of grouting reinforcement in mitigating water inrush disaster.The results indicate that increased grouting pressure greatly affects the regulation of water outflow from the tunnel face and the prevention of rock detachment face after excavation. 展开更多
关键词 discontinuous deformation analysis(DDA) Water-rich fractured rock tunnel Grouting reinforcement Water inrush disaster
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Suppression of discontinuous precipitation by Fe addition in Cu-Ti alloys 被引量:1
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作者 Xu Wang Zhu Xiao +1 位作者 Yu Chen Zhou Li 《Rare Metals》 2025年第3期1982-1997,共16页
Cu-Ti alloys are a kind of elastic copper alloys with excellent comprehensive properties.They are often used in electronic and electrical fields.However,discontinuous precipitation may occur during the preparation pro... Cu-Ti alloys are a kind of elastic copper alloys with excellent comprehensive properties.They are often used in electronic and electrical fields.However,discontinuous precipitation may occur during the preparation process of Cu-Ti alloys,and they can lead to the significant deterioration of mechanical properties.To solve this problem,three Cu-Ti alloys with various Fe contents(Cu-2.7Ti,Cu-2.7Ti-0.1Fe and Cu-2.7Ti-0.2Fe)were designed and prepared in this paper to investigate the effects of Fe on the discontinuous precipitation.The results showed that after aging at any given aging time and temperature,the area fraction of cellular structure decreased with the increase of Fe content.The addition of Fe into Cu-Ti alloys resulted in Fe doping inβ'-Cu_(4)Ti phase andβ-Cu_(4)Ti phase.For 450℃/144 h-aged Cu-2.7Ti-0.2Fe alloy,the Fe content inβ'-Cu_(4)Ti phase andβ-Cu_(4)Ti phase was 1.59 at%and 0.90 at%,respectively.The tensile tests showed that under the same aging treatment conditions,Cu-2.7Ti-0.2Fe alloy possessed better mechanical properties.First-principles calculation confirmed that the thermodynamic stability ofβ'-Cu_(4)Ti phase was enhanced by decreasing its cohesive energy through Fe doping.At the same time,the enthalpy of formation ofβ-Cu_(4)Ti phase was generally increased by Fe doping,making it difficult to generate.In short,Fe addition in Cu-Ti alloys suppressed discontinuous precipitation by Fe doping in the precipitates and helped to improve mechanical properties. 展开更多
关键词 Cu-Ti-Fe alloys discontinuous precipitation First-principles calculation
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Study on the ion behavior of solid-phase reaction synthesis of iron chromite at 1473 K
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作者 Yan Wang Peiyuan Ni +1 位作者 Yuling Liu Tengfei Deng 《International Journal of Minerals,Metallurgy and Materials》 2025年第5期1103-1113,共11页
The enrichment of chromium in the magnetic iron chromite(Fe(Cr_(x)Fe_(1-x))_(2)O_(4))phase is crucial for the recovery and recycling of chromium in stainless-steel pickling sludge.The kinetics and reaction mechanism o... The enrichment of chromium in the magnetic iron chromite(Fe(Cr_(x)Fe_(1-x))_(2)O_(4))phase is crucial for the recovery and recycling of chromium in stainless-steel pickling sludge.The kinetics and reaction mechanism of the solid-phase reaction between Fe_(3)O_(4)and Cr_(2)O_(3)were investigated using the diffusion couple method at 1473 K.Not only the diffusion behavior of Fe^(2+)ions and Cr^(3+)ions was elucidated,but also the solid solution behavior of Fe^(3+)ions was discussed clearly.The microscopic morphology of the diffusion couple and the change in the concentrations of Fe and Cr cations across the diffusion layers were analyzed using scanning electron microscopy and en-ergy dispersive spectroscopy.The self-diffusion coefficients of cations were calculated based on the concentration profiles of Fe and Cr,with the results indicating that the self-diffusion coefficient of the Fe ions was consistently higher than that of the Cr ions.Additionally,a mixture of Fe_(3)O_(4)and Cr_(2)O_(3)was annealed at 1373-1473 K for 1-5 h,and the kinetic parameters were calculated by studying the phase content of the product.The phase content of Fe(Cr_(x)Fe_(1-x))_(2)O_(4)in the product was determined by Rietveld refinement of X-ray diffraction data,revealing that an activation energy(E)of 177.20 kJ·mol^(-1) and a pre-exponential factor(B)of 610.78 min^(-1)of the solid-phase reac-tion that produced the Fe(Cr_(x)Fe_(1-x))_(2)O_(4)spinel. 展开更多
关键词 diffusion couple solid-phase reaction KINETICS iron chromite
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The role of grain and twin boundaries on discontinuous precipitation of Mg_(17)Al_(12) phase in Mg-Al alloy
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作者 Yi Wang Fei Guo +6 位作者 Luyao Jiang Hang Yu Gege Wang Congren Shen Zhongwei Wang Linjiang Chai Yanlong Ma 《Journal of Magnesium and Alloys》 2025年第6期2855-2865,共11页
Mechanism of discontinuous precipitation(DP) in AZ80 alloy was investigated by phase-orientation correlated characterization.The results show DPs nucleate by turning the original grain boundaries(GBs) as reaction fron... Mechanism of discontinuous precipitation(DP) in AZ80 alloy was investigated by phase-orientation correlated characterization.The results show DPs nucleate by turning the original grain boundaries(GBs) as reaction front(RF),and further driving the RF to realize their growth.The DPs regions retained the same orientations as their parent grains.The misorientation angle and rotation axis of RFs had strong influence on DPs nucleation.The low-angle GBs,twin boundaries(TBs) and the GBs with specific misorientation axis which are known as low energy and low mobility GBs can hardly initiate DPs.In addition,the TBs had a strong ability to inhibit the growth of DPs,but it should be noticed that the growth of DPs cannot be totally inhibited by TBs.DPs can engulf the twins when the growth direction is approximately parallel to the long axis of TBs.The inhibition behavior is related to the distribution of Al solute atoms near the RF,boundary interactions of the TBs and twin tips with the RF,and the morphology of the continuous precipitations within the twins. 展开更多
关键词 AZ80 alloy discontinuous precipitation Grain boundary MISORIENTATION Extension twinning
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Unraveling the Discontinuous Dynamic Recrystallization of the TC17 Titanium Alloy during Hot Deformation by Crystal Plasticity Modeling
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作者 Xiangru Guo Jian Zhang +4 位作者 Tieqiang Kong Junjie Shen Qingjian Liu Chaoyang Sun Peipei Li 《Acta Metallurgica Sinica(English Letters)》 2025年第12期2243-2264,共22页
A dislocation density-based crystal plasticity finite element(CPFE)model is developed to reveal the mechanism of discontinuous dynamic recrystallization(DDRX)of the TC17 dual-phase titanium alloy during hot deformatio... A dislocation density-based crystal plasticity finite element(CPFE)model is developed to reveal the mechanism of discontinuous dynamic recrystallization(DDRX)of the TC17 dual-phase titanium alloy during hot deformation.The model incorporates the temperature and strain rate dependence of nucleation,growth and evolution during DDRX.The evolution of the dislocation densities in the matrix grains(MGs)and the recrystallized grains(RGs)is considered individually.The mechanical response and underlying microstructural evolution are systematically investigated by comparing the CPFE model predictions with experimental tests.The results indicate that at lower temperatures(700℃ and 800℃),TC17 titanium alloy exhibits a higher volume fraction of recrystallization and a notable drop in flow stress.As the temperature increases(900℃ and 1000℃),the volume fraction of recrystallization decreases,resulting in a weakened flow stress softening.The nucleation rate of DDRX increases with decreasing deformation temperature and increasing strain rate,while the size of RGs increases with higher temperature and lower strain rate.DDRX nuclei primarily occur at grain boundaries with high dislocation density.Furthermore,DDRX consumes a large number of dislocations and thus reduces the stress concentration and dislocation density at grain boundaries.This study provides a robust model that enhances the understanding of hot deformation mechanisms and informs the design of high-performance titanium alloys for future applications. 展开更多
关键词 Crystal plasticity Dual-phase titanium alloy discontinuous dynamic recrystallization Dislocation density
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A Posteriori Error Estimate of Multiphysics Discontinuous Galerkin Method for a Poroelasticity
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作者 GE Zhi-hao HE Wen-long MA Meng-xia 《Chinese Quarterly Journal of Mathematics》 2025年第3期238-261,共24页
In this paper,we design a new error estimator and give a posteriori error analysis for a poroelasticity model.To better overcome“locking phenomenon”on pressure and displacement,we proposed a new error estimators bas... In this paper,we design a new error estimator and give a posteriori error analysis for a poroelasticity model.To better overcome“locking phenomenon”on pressure and displacement,we proposed a new error estimators based on multiphysics discontinuous Galerkin method for the poroelasticity model.And we prove the upper and lower bound of the proposed error estimators,which are numerically demonstrated to be computationally very efficient.Finally,we present numerical examples to verify and validate the efficiency of the proposed error estimators,which show that the adaptive scheme can overcome“locking phenomenon”and greatly reduce the computation cost. 展开更多
关键词 Poroelasticity model A posteriori error Multiphysics discontinuous Galerkin method
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Highly efficient contact detection strategy of 3D discontinuous deformation analysis in continuous-discontinuous simulation
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作者 Jingyu Kang Xiaodong Fu +5 位作者 Qian Sheng Xing Wang Haifeng Ding Xuehan Zhao Tian Xi Shangwei Jiang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第11期6977-6992,共16页
Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this stud... Contact detection is the most time-consuming stage in 3D discontinuous deformation analysis(3D-DDA)computation.Improving the efficiency of 3D-DDA is beneficial for its application in large-scale computing.In this study,aiming at the continuous-discontinuous simulation of 3D-DDA,a highly efficient contact detection strategy is proposed.Firstly,the global direct search(GDS)method is integrated into the 3D-DDA framework to address intricate contact scenarios.Subsequently,all geometric elements,including blocks,faces,edges,and vertices are divided into searchable and unsearchable parts.Contacts between unsearchable geometric elements would be directly inherited,while only searchable geometric elements are involved in contact detection.This strategy significantly reduces the number of geometric elements involved in contact detection,thereby markedly enhancing the computation efficiency.Several examples are adopted to demonstrate the accuracy and efficiency of the improved 3D-DDA method.The rock pillars with different mesh sizes are simulated under self-weight.The deformation and stress are consistent with the analytical results,and the smaller the mesh size,the higher the accuracy.The maximum speedup ratio is 38.46 for this case.Furthermore,the Brazilian splitting test on the discs with different flaws is conducted.The results show that the failure pattern of the samples is consistent with the results obtained by other methods and experiments,and the maximum speedup ratio is 266.73.Finally,a large-scale impact test is performed,and approximately 3.2 times enhanced efficiency is obtained.The proposed contact detection strategy significantly improves efficiency when the rock has not completely failed,which is more suitable for continuous-discontinuous simulation. 展开更多
关键词 3D discontinuous deformation analysis Contact detection Computation efficiency Continuous-discontinuous simulation FRACTURE
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PERIODICITY AND FIXED-TIME STABILIZATION OF DISCONTINUOUS NEURAL NETWORKS WITH MIXED DELAYS: UNBOUNDED DELAY-DEPENDENT CRITERIA
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作者 Ziwei WANG Lin SUN +1 位作者 Fanchao KONG Rathinasamy SAKTHIVEL 《Acta Mathematica Scientia》 2025年第3期1188-1204,共17页
In this paper, a class of discontinuous neutral-type neural networks (NTNNs) with proportional delays is considered. The targets of the paper are to study the problem of periodic solutions and fixed-time (FXT) stabili... In this paper, a class of discontinuous neutral-type neural networks (NTNNs) with proportional delays is considered. The targets of the paper are to study the problem of periodic solutions and fixed-time (FXT) stabilization of the addressed neural networks. In order to complete the targets, based on set-valued map, differential inclusions theory, coincidence theorem and Hölder inequality technique, some new proportional delay-dependent criteria shown by the inequalities are derived. Based on the fact of the existence of solution, further by applying the FXT stability lemmas and equivalent transformation, the zero solution of closed-loop system achieves FXT stabilization and the corresponding settling-times are estimated. Some previous related works on NTNNs are extended. Finally, one typical example is provided to show the effectiveness of the established results. 展开更多
关键词 Fixed-time stabilization Periodic solutions discontinuous neural systems D-ifferential inclusions theory Proportional delays
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Efficient implementation of the k-√k L turbulence model with the discontinuous Galerkin method
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作者 Zhenhua Jiang Chao Yan +1 位作者 Jian Yu Yao Li 《Acta Mechanica Sinica》 2025年第4期70-81,共12页
We present the approaches to implementing the k-√k L turbulence model within the framework of the high-order discontinuous Galerkin(DG)method.We use the DG discretization to solve the full Reynolds-averaged Navier-St... We present the approaches to implementing the k-√k L turbulence model within the framework of the high-order discontinuous Galerkin(DG)method.We use the DG discretization to solve the full Reynolds-averaged Navier-Stokes equations.In order to enhance the robustness of approaches,some effective techniques are designed.The HWENO(Hermite weighted essentially non-oscillatory)limiting strategy is adopted for stabilizing the turbulence model variable k.Modifications have been made to the model equation itself by using the auxiliary variable that is always positive.The 2nd-order derivatives of velocities required in computing the von Karman length scale are evaluated in a way to maintain the compactness of DG methods.Numerical results demonstrate that the approaches have achieved the desirable accuracy for both steady and unsteady turbulent simulations. 展开更多
关键词 discontinuous Galerkin method k-√k L turbulence model High-order scheme
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A discontinuous smooth particle hydrodynamics method for modeling deformation and failure processes of fractured rocks
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作者 Chengzhi Xia Zhenming Shi +1 位作者 Bo Li Maomao Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第2期705-721,共17页
A discontinuous smoothed particle hydrodynamics(DSPH)method considering block contacts is originally developed to model the cracking,frictional slip and large deformation in rock masses,and is verified by theoretical,... A discontinuous smoothed particle hydrodynamics(DSPH)method considering block contacts is originally developed to model the cracking,frictional slip and large deformation in rock masses,and is verified by theoretical,numerical and/or experimental results.In the DSPH method,cracking is realized by breaking the virtual bonds via a pseudo-spring method based on Mohr–Coulomb failure criteria.The damaged particles are instantaneously replaced by discontinuous particles and the contact bond between the original and discontinuous particles is formed to simulate the frictional slip and separation/contraction between fracture surfaces based on the block contact algorithm.The motion of rock blocks and the contact force of discontinuous particles are determined following Newton's second law.The results indicate that the DSPH method precisely captures the cracking,contact formation and complete failure across six numerical benchmark tests.This single smoothed particle hydrodynamics(SPH)framework could significantly improve computational efficiency and is potentially applicable to broad multi-physical rock engineering problems of different scales. 展开更多
关键词 discontinuous smoothed particle hydrodynamics(DSPH) Pseudo-spring method CRACKING CONTACT Frictional slip
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Optimizing the overall performance of Cu–Ni–Si alloy via controllingnanometer-lamellar discontinuous precipitation structure
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作者 Jinyu Liang Guoliang Xie +3 位作者 Feixiang Liu Wenli Xue Rui Wang Xinhua Liu 《International Journal of Minerals,Metallurgy and Materials》 2025年第4期915-924,共10页
Simultaneously achieving high strength and high electrical conductivity in Cu–Ni–Si alloys pose a significant challenge, which greatly constrains its applications in the electronics industry. This paper offers a new... Simultaneously achieving high strength and high electrical conductivity in Cu–Ni–Si alloys pose a significant challenge, which greatly constrains its applications in the electronics industry. This paper offers a new pathway to improve properties, by preparation of nanometer lamellar discontinuous precipitates(DPs) arranged with the approximate same direction through a combination of deformationaging and cold rolling process. The strengthening effect is primarily attributed to nanometer-lamellar DPs strengthening and dislocation strengthening mechanism. The accumulation of dislocations at the interface between nanometer lamellar DPs and matrix during cold deformation process can results in the decrease of dislocation density inside the matrix grains, leading to the acceptably slight reduction of electrical conductivity during cold rolling. The alloy exhibits an electrical conductivity of 45.32%IACS(international annealed copper standard, IACS), a tensile strength of 882.67 MPa, and a yield strength of 811.33 MPa by this method. This study can provide a guidance for the composition and microstructure design of a Cu–Ni–Si alloy in the future, by controlling the morphology and distribution of DPs. 展开更多
关键词 Cu–Ni–Si alloys discontinuous precipitates nanometer-lamellar strengthening dislocation strengthening
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Origin of high strength and good ductility of TiH_(2)-based powder metallurgy titanium alloy with discontinuous lamellar structures
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作者 Hai-rui ZHANG Hong-zhi NIU +3 位作者 Chao YANG Nan XIANG De-liang ZHANG Fu-xiao CHEN 《Transactions of Nonferrous Metals Society of China》 2025年第10期3342-3356,共15页
A unique discontinuous lamellar microstructure of titanium alloys consisting of lamellar colonies at prior β-Ti grain boundaries and internal interwoven α-laths is prepared by a TiH_(2)-based powder metallurgy metho... A unique discontinuous lamellar microstructure of titanium alloys consisting of lamellar colonies at prior β-Ti grain boundaries and internal interwoven α-laths is prepared by a TiH_(2)-based powder metallurgy method.The α-variants get various crystallographic orientations and become discontinuous during vacuum annealing at 700℃.Remarkably,nanoscale phase δ-TiH compound layers are generated between α-laths and β-strips,so that dislocations are piled up at the α/δ/βinterfaces during tensile deformation.This leads to dislocation slips being confined to individual α-laths,with differentslips and particularly pyramidal<c+a>slips being activated.The efficiency of wavy slip is promoted and the work hardening rate is enhanced.Finally,the combined effect of dispersed micro-shear bands and lath distortions is considered contributive for alleviating the stress concentration at grain boundaries,resulting in a high-promising synergy of enhanced ultimate tensile strength of 1080 MPa and good elongation to fracture of 13.6%. 展开更多
关键词 TiH_(2)-based powder metallurgy discontinuous lamellar microstructure interfacialδ-TiH phase tensile properties deformation behavior
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Automated recognition of rock discontinuity in underground engineering using geometric feature analysis
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作者 Adili Rusuli Xiaojun Li +1 位作者 Yuyun Wang Yi Rui 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1016-1033,共18页
Discontinuities in rock masses critically impact the stability and safety of underground engineering.Mainstream discontinuities identificationmethods,which rely on normal vector estimation and clustering algorithms,su... Discontinuities in rock masses critically impact the stability and safety of underground engineering.Mainstream discontinuities identificationmethods,which rely on normal vector estimation and clustering algorithms,suffer from accuracy degradation,omission of critical discontinuities when orientation density is unevenly distributed,and need manual intervention.To overcome these limitations,this paper introduces a novel discontinuities identificationmethod based on geometric feature analysis of rock mass.By analyzing spatial distribution variability of point cloud and integrating an adaptive region growing algorithm,the method accurately detects independent discontinuities under complex geological conditions.Given that rock mass orientations typically follow a Fisher distribution,an adaptive hierarchical clustering algorithm based on statistical analysis is employed to automatically determine the optimal number of structural sets,eliminating the need for preset clusters or thresholds inherent in traditional methods.The proposed approach effectively handles diverse rock mass shapes and sizes,leveraging both local and global geometric features to minimize noise interference.Experimental validation on three real-world rock mass models,alongside comparisons with three conventional directional clustering algorithms,demonstrates superior accuracy and robustness in identifying optimal discontinuity sets.The proposed method offers a reliable and efficienttool for discontinuities detection and grouping in underground engineering,significantlyenhancing design and construction outcomes. 展开更多
关键词 Underground engineering Rock mass discontinuity Orientation grouping Fisher distribution 3D point cloud Automated recognition
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Discontinuation of advanced therapy in inflammatory bowel disease:Updated evidence,guidelines,and personalized decision-making one year later
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作者 Salvatore Greco Michele Campigotto NicolòFabbri 《World Journal of Clinical Cases》 2026年第1期52-56,共5页
Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the... Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the publication by Meštrovićet al,emphasizing the complex balance between risks of relapse,antidrug antibody formation,and potential complications of long-term immunosuppression.Recent evidence underscores high relapse rates following withdrawal-especially of anti-tumor necrosis factor agents-and highlights the lack of robust data for newer biologics.Updated guidelines from European Crohn’s and Colitis Organization,British Society of Gastroenterology,and American College of Gastroenterology all support cautious and individualized approaches,with strict criteria and close follow-up,particularly in Crohn’s disease.For ulcerative colitis,therapeutic cycling remains insufficiently addressed.We proposed a flowchart to support clinical decision-making and stress the importance of shared decisionmaking in the era of personalized medicine since,despite new drug classes and evolving strategies,the therapeutic ceiling in inflammatory bowel disease has yet to be fully overcome. 展开更多
关键词 Crohn’s disease Ulcerative colitis Inflammatory bowel disease Biologic therapy discontinuation of therapy Personalized medicine
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Intelligent characterization of discontinuities and heterogeneity evaluation of potential hazard sources in high-steep rock slope by TLS-UAV technology
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作者 Changqing Liu Han Bao +5 位作者 Tianyi Wang Jingfeng Zhang Hengxing Lan Shengwen Qi Wei Yuan Shunichi Koshimura 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期509-527,共19页
The identification of rock mass hazard sources is fundamental for preventing rockfall and landslide disasters in mountainous regions,with rock mass structural characteristics playing a vital role in hazard assessment.... The identification of rock mass hazard sources is fundamental for preventing rockfall and landslide disasters in mountainous regions,with rock mass structural characteristics playing a vital role in hazard assessment.In this study,terrestrial laser scanning(TLS)and unmanned aerial vehicle(UAV)technologies were integrated to enhance the evaluation methodology for rock mass hazard sources,focusing on the Sichuan Yanjiang Expressway project in China.The findings demonstrate that TLS-UAV technology enhanced both spatial coverage and data density in slope modeling.Through integrated algorithmic analysis,rock discontinuities within heterogeneous datasets were systematically identified,enabling quantitative extraction and statistical analysis of key geometric parameters,including orientation,trace length,spacing,and roughness.Furthermore,quantitative models were developed for cohesion,friction angle and the morphology parameter M of in situ discontinuities,respectively,facilitating efficient mechanical parameter acquisition.A novel rock mass hazard index(RHI)was developed incorporating discontinuity geometric rating(DGR),discontinuity mechanical rating(DMR),and slope mass rating(SMR).Field validation confirmed the methodology's effectiveness in evaluating risk levels and spatial heterogeneity of rock mass hazard sources,revealing the contribution of different discontinuity sets to the rock mass hazard and identifying the primary discontinuity sets controlling instability mechanisms.This study is of great significance for evaluating discontinuity-controlled rock mass hazard sources and preventing rockfall disasters. 展开更多
关键词 High-steep slope Rock mass hazard source discontinuITIES Intelligent characterization Terrestrial laser scanning(TLS) Unmanned aerial vehicle(UAV)
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A new algorithm for high-speed identificationof discontinuities on large-scale rock outcrop:A case study in Jinsha River suture zone
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作者 Jiali Han Jia Wang +6 位作者 Wenchuan Dong Shuonan Wang Qi Sun Tengyue Li Zhengxuan Xu Yingxu Zhang Wen Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1250-1265,共16页
Automatic identificationof discontinuities is a key focus in rock slope research.Conventional methods typically target small areas,which limits efficiencyand applicability for complex discontinuities in large-scale ro... Automatic identificationof discontinuities is a key focus in rock slope research.Conventional methods typically target small areas,which limits efficiencyand applicability for complex discontinuities in large-scale rock slopes.This study uses multi-angle unmanned aerial vehicle(UAV)nap-of-the-object photogrammetry to construct a high-definitionthree-dimensional(3D)point cloud model of the slope.The edge-firstconnection algorithm identifiesall edge points of discontinuities in the point cloud and completes recognition through simple connection analysis.This method avoids the complex calculations required for sequentially identifying discontinuity edges in conventional methods and achieves significantacceleration through algorithm optimization and parallel computation support.Based on this algorithm,the RockDiscontinuity Identification(RD ID)software is developed and applied to identify numerous highly disordered discontinuities on the Xulong slope in the Jinsha River suture zone.Processing tens of millions of point clouds within approximately 2 h demonstrates exceptional computational efficiency.The automatic algorithm accurately identifiesnearly 80%of planar discontinuities,with orientations and trace lengths closely matching manual results,highlighting its potential for large-scale rock outcrop applications.Comparisons with region growing algorithms further emphasize its effectiveness and accuracy.However,the algorithm struggles to identify linear discontinuities,which are a major source of error.Additionally,high roughness and smooth edges of discontinuities affect recognition accuracy,indicating areas for further improvement. 展开更多
关键词 Rock discontinuity Suture zone Automatic recognition Three-dimensional(3D)point cloud Unmanned aerial vehicle(UAV) PHOTOGRAMMETRY
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Low temperature solid-phase sintering of sintered metal fibrous media with high specific surface area 被引量:4
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作者 唐彪 汤勇 +3 位作者 周蕤 陆龙生 刘彬 屈修明 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第8期1755-1760,共6页
A procedure of low temperature solid-phase sintering(LTSS) was carried out to fabricate sintered metal fibrous media(SMFM) with high specific surface area.Stainless steel fibers which were produced by cutting proc... A procedure of low temperature solid-phase sintering(LTSS) was carried out to fabricate sintered metal fibrous media(SMFM) with high specific surface area.Stainless steel fibers which were produced by cutting process were first plated with a coarse copper coating layer by electroless plating process.A low-temperature sintering process was then completed at about 800 °C for 1 h under the protection of hydrogen atmosphere.The results show that a novel SMFM with complex surface morphology and high specific surface area(0.2 m2/g) can be obtained in this way.The effect of sintering temperature on the surface morphology and specific surface area of SMFM was studied by means of scanning electron microscopy and Brunauer-Emmett-Teller.The damage of micro-structure during the sintering process mainly contributed to the loss of specific surface area of SMFM and the optimal sintering temperature was 800 °C. 展开更多
关键词 sintered metal fibrous media low temperature solid-phase sintering electroless copper plating surface morphology specific surface area
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Simulated and experimental investigation on discontinuous dynamic recrystallization of a near-α TA15 titanium alloy during isothermal hot compression in βsingle-phase field 被引量:7
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作者 武川 杨合 李宏伟 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第6期1819-1829,共11页
A cellular automaton(CA) modeling of discontinuous dynamic recrystallization(DDRX) of a near-α Ti-6Al-2Zr-1Mo-1V(TA15) isothermally compressed in the β single phase field was presented.In the CA model,nucleati... A cellular automaton(CA) modeling of discontinuous dynamic recrystallization(DDRX) of a near-α Ti-6Al-2Zr-1Mo-1V(TA15) isothermally compressed in the β single phase field was presented.In the CA model,nucleation of the β-DDRX and the growth of recrystallized grains(re-grains) were considered and visibly simulated by the CA model.The driving force of re-grain growth was provided by dislocation density accumulating around the grain boundaries.To verify the CA model,the predicted flow stress by the CA model was compared with the experimental data.The comparison showed that the average relative errors were10.2%,10.1%and 6%,respectively,at 1.0,0.1 and 0.01 s^-1 of 1020 ℃,and were 10.2%,11.35%and 7.5%,respectively,at 1.0,0.1and 0.01 s^-1 of 1050 ℃.The CA model was further applied to predicting the average growth rate,average re-grain size and recrystallization kinetics.The simulated results showed that the average growth rate increases with the increasing strain rate or temperature,while the re-grain size increases with the decreasing strain rate;the volume fraction of recrystallization decreases with the increasing strain rate or decreasing temperature. 展开更多
关键词 discontinuous dynamic recrystallization cellular automaton dislocation density evolution recrystallization kinetics TA15 titanium alloy
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