Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education....The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.To do so,there is a need to understand the impact of LLMs on software engineering education.In this paper,we conducted a preliminary case study on three software requirements engineering classes where students are allowed to use LLMs to assist in their projects.Based on the students’experience,performance,and feedback from a survey conducted at the end of the courses,we characterized the challenges and benefits of applying LLMs in software engineering education.This research contributes to the ongoing discourse on the integration of LLMs in education,emphasizing both their prominent potential and the need for balanced,mindful usage.展开更多
With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a co...With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a comparative study of software engineering education in China and Europe,aiming to explore the theoretical frameworks and practical pathways employed in both regions.Initially,we introduce and contrast the engineering education accreditation systems of China and Europe,including the Chinese engineering education accreditation framework and the European EUR-ACE(European Accreditation of Engineering Programmes)standards,highlighting their core principles and evaluation methodologies.Subsequently,we provide case studies of several universities in China and Europe,such as Sun Yat-sen University,Tsinghua University,Technical University of Munich,and Imperial College London.Finally,we offer recommendations to foster mutual learning and collaboration between Chinese and European institutions,aiming to enhance the overall quality of software engineering education globally.This work provides valuable insights for educational administrators,faculty members,and policymakers,contributing to the ongoing improvement and innovative development of software engineering education in China and Europe.展开更多
Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu...Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.展开更多
To address the severe challenges posed by the international situation and meet the needs of the national major development strategies,the traditional software engineering talent cultivation model lacks interdisciplina...To address the severe challenges posed by the international situation and meet the needs of the national major development strategies,the traditional software engineering talent cultivation model lacks interdisciplinary education focused on specific fields,making it difficult to cultivate engineering leaders with multidisciplinary backgrounds who are capable of solving complex real-world problems.To solve this problem,based on the decade-long interdisciplinary talent cultivation achievements of the College of Software Engineering at Sichuan University,this article proposes the“Software Engineering+”innovative talent cultivation paradigm.It provides an analysis through professional construction of interdisciplinary talents,the design of talent cultivation frameworks,the formulation of cultivation plans,the establishment of interdisciplinary curriculum systems,the reform of teaching modes,and the improvement of institutional systems.Scientific solutions are proposed,and five project models implemented and operated by the College of Software Engineering at Sichuan University are listed as practical examples,offering significant reference value.展开更多
With the rapid development of software engineering,traditional teaching methods are confronted with the challenges of short knowledge update cycles and the rapid emergence of new technologies.By analyzing the current ...With the rapid development of software engineering,traditional teaching methods are confronted with the challenges of short knowledge update cycles and the rapid emergence of new technologies.By analyzing the current situation of the mismatch between educational practices and industrial change,this study proposes an innovative teaching model—“Micro-practices”.This model integrates new knowledge and new technologies into the teaching process quickly and flexibly through practical teaching projects with“short class time,small capacity,and cloud environment”to meet the different educational needs of students,teachers,and enterprises.The aim is to train innovative software engineering talents who can meet the challenges of the future.展开更多
Quantum software development utilizes quantum phenomena such as superposition and entanglement to address problems that are challenging for classical systems.However,it must also adhere to critical quantum constraints...Quantum software development utilizes quantum phenomena such as superposition and entanglement to address problems that are challenging for classical systems.However,it must also adhere to critical quantum constraints,notably the no-cloning theorem,which prohibits the exact duplication of unknown quantum states and has profound implications for cryptography,secure communication,and error correction.While existing quantum circuit representations implicitly honor such constraints,they lack formal mechanisms for early-stage verification in software design.Addressing this constraint at the design phase is essential to ensure the correctness and reliability of quantum software.This paper presents a formal metamodeling framework using UML-style notation and and Object Constraint Language(OCL)to systematically capture and enforce the no-cloning theorem within quantum software models.The proposed metamodel formalizes key quantum concepts—such as entanglement and teleportation—and encodes enforceable invariants that reflect core quantum mechanical laws.The framework’s effectiveness is validated by analyzing two critical edge cases—conditional copying with CNOT gates and quantum teleportation—through instance model evaluations.These cases demonstrate that the metamodel can capture nuanced scenarios that are often mistaken as violations of the no-cloning theorem but are proven compliant under formal analysis.Thus,these serve as constructive validations that demonstrate the metamodel’s expressiveness and correctness in representing operations that may appear to challenge the no-cloning theorem but,upon rigorous analysis,are shown to comply with it.The approach supports early detection of conceptual design errors,promoting correctness prior to implementation.The framework’s extensibility is also demonstrated by modeling projective measurement,further reinforcing its applicability to broader quantum software engineering tasks.By integrating the rigor of metamodeling with fundamental quantum mechanical principles,this work provides a structured,model-driven approach that enables traditional software engineers to address quantum computing challenges.It offers practical insights into embedding quantum correctness at the modeling level and advances the development of reliable,error-resilient quantum software systems.展开更多
Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance...Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance for fully implementing the“Excellent Engineer Education and Training Program”of the Ministry of Education and achieving the goal of building a strong engineering education country.The School of Information and Software Engineering of the University of Electronic Science and Technology of China(UESTC)has been thoroughly studying and implementing Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and the spirit of the 20th CPC National Congress.The school has steadfastly promoted the Project of Nurturing the Soul of the New Era.The school has taken moral education as its core,deeply explored the resources of“all staff,throughout the process,in all aspects”,and constructed and implemented the collaborative education mechanism.These efforts have laid a solid foundation for cultivating excellent talents in software engineering in the new era.展开更多
Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,wri...Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,writing test cases,conducting functional and performance tests,and optimizing the product based on feedback.In government procurement projects,quality evaluation focuses on process compliance,security,and functional compatibility.KPI evaluation trees are commonly used for quantitative assessment,and a dynamic adjustment mechanism for indicators needs to be established to cope with complex demands.In addition,risk-driven testing and agile development should be combined to set up quality access control to ensure that each iteration version meets expectations.The multi-dimensional quality assurance and verification scoring mechanism can effectively enhance product reliability and reduce project risks.展开更多
This paper presents a case study of the collaborative integration between the School of Information and Software Engineering at the University of Electronic Science and Technology of China(UESTC)and SI-TECH,highlighti...This paper presents a case study of the collaborative integration between the School of Information and Software Engineering at the University of Electronic Science and Technology of China(UESTC)and SI-TECH,highlighting the complementary advantages of both the University and the enterprise.By jointly establishing research institutes and engaging in diversified collaborative initiatives,the University and the enterprise have embarked on a pathway of School-enterprise Integration.Through a virtuous cycle of cooperation and continuous advancement,they have explored a comprehensive talent cultivation model in“5G”software engineering innovation practices based on this integration.Furthermore,this endeavor aims to facilitate the transformation of technological achievements and provides valuable insights for fostering innovative talents in the field of electronic information through enhanced integration between the University and the enterprise.展开更多
This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information tec...This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information technology and computer software engineering.Then,it deeply analyzes the application status and significance of the integration application of information technology and computer software engineering in different fields.Finally,it briefly describes the specific application paths of the integration of information technology and computer software engineering,hoping to provide some valuable references for promoting the in-depth integration and development of information technology and computer software engineering.展开更多
In response to the current issues in the construction of software engineering(SE)degree granting program,such as insufficient resource integration,low level of internationalization,and inadequate quality control,we pr...In response to the current issues in the construction of software engineering(SE)degree granting program,such as insufficient resource integration,low level of internationalization,and inadequate quality control,we propose the Software Engineering Degree Granting Program Construction Practice Project at Harbin Institute of Technology(HIT).This project aims to explore new models for software talent cultivation,establish a superior SE degree granting program,and ultimately cultivate outstanding internationalized composite SE professionals to support the high-quality development of the national software industry.To this end,we design a distinctive overall construction idea and plan for the SE degree granting program,which are characterized by“3I3S:three highlights for specialized cultivation and strictness in three aspects to ensure quality control”.After years of practice and validation of the project at the School of Software at HIT,this project has proven effective in optimizing talent cultivation models,enhancing students’practical abilities,promoting international exchange and cooperation,advancing industry-education integration,and meeting industrial needs.展开更多
The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engin...The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engineering into IoT engineering education remains underexplored.To address this gap,the School of Software at North University of China,in collaboration with QST Innovation Technology Group Co.,Ltd.(QST),has developed an innovative educational mechanism.This initiative focuses on the software engineering IoT track and optimizes the teaching process through the outcome-based education(OBE)concept.It incorporates military-industrial characteristics,introduces advanced information and technology curricula,and enhances laboratory infrastructure.The goal is to cultivate innovative talents with unique capabilities,thereby fostering the comprehensive development and application of IoT technology.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and pra...Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary.展开更多
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien...Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
How to improve the employment of software engineering graduates, especially, how to effectively enhance the employment competitiveness of relevant overseas students in the context of "One Belt and One Road" ...How to improve the employment of software engineering graduates, especially, how to effectively enhance the employment competitiveness of relevant overseas students in the context of "One Belt and One Road" is one of the core tasks of overseas Chinese universities. This paper proposes a reform plan for the practical training mode of school-enterprise cooperative project in the software engineering of overseas Chinese universities. The reform plan combines education concepts with practical research and development. It subdivides students and according to the characteristics of different types of students, and is carried out on campus, outside campus(in the province), and abroad(original area), which makes senior undergraduates fully understand the needs of enterprises, constantly improve their professional practice ability, and improve their competitiveness. Thus, the professional innovation and entrepreneurship ability of students is enhanced, and it also reduces the cost of employee entry.展开更多
Practice is an important phase in the teaching of software engineering.How to improve students' practical ability is a common problem for many software colleges.The course of Software Project Practice is proposed ...Practice is an important phase in the teaching of software engineering.How to improve students' practical ability is a common problem for many software colleges.The course of Software Project Practice is proposed to enhance students' practical skills.In this course,the students participate in the whole process of software development practice and take the exercise of entrepreneurial project development in their learning stage.展开更多
The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金supported in part by the Teaching Reform Project of Chongqing University of Posts and Telecommunications,China under Grant No.XJG23234Chongqing Municipal Higher Education Teaching Reform Research Project under Grant No.203399the Doctoral Direct Train Project of Chongqing Science and Technology Bureau under Grant No.CSTB2022BSXM-JSX0007。
文摘The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.To do so,there is a need to understand the impact of LLMs on software engineering education.In this paper,we conducted a preliminary case study on three software requirements engineering classes where students are allowed to use LLMs to assist in their projects.Based on the students’experience,performance,and feedback from a survey conducted at the end of the courses,we characterized the challenges and benefits of applying LLMs in software engineering education.This research contributes to the ongoing discourse on the integration of LLMs in education,emphasizing both their prominent potential and the need for balanced,mindful usage.
基金supported by the Guangdong Higher Education Association’s“14th Five Year Plan”2024 Higher Education Research Project(24GYB03)the Natural Science Foundation of Guangdong Province(2024A1515010255)。
文摘With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a comparative study of software engineering education in China and Europe,aiming to explore the theoretical frameworks and practical pathways employed in both regions.Initially,we introduce and contrast the engineering education accreditation systems of China and Europe,including the Chinese engineering education accreditation framework and the European EUR-ACE(European Accreditation of Engineering Programmes)standards,highlighting their core principles and evaluation methodologies.Subsequently,we provide case studies of several universities in China and Europe,such as Sun Yat-sen University,Tsinghua University,Technical University of Munich,and Imperial College London.Finally,we offer recommendations to foster mutual learning and collaboration between Chinese and European institutions,aiming to enhance the overall quality of software engineering education globally.This work provides valuable insights for educational administrators,faculty members,and policymakers,contributing to the ongoing improvement and innovative development of software engineering education in China and Europe.
基金supported by grants from the Jiangxi Provincial Natural Science Foundation,No.20242BAB26134(to XF)the National Natural Science Foundation of China,Nos.82060638(to TC),82060222(to XF),82460237(to XF)+1 种基金the Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,Nos.20194BCJ22032(to TC),20213BCJL22049(to XF)Science and Technology Plan of Jiangxi Health Planning Committee,No.202210390(to XF).
文摘Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.
基金supported by the 2023 Sichuan Province Higher Education Talent Cultivation and Teaching Reform Major Project“Exploration and Practice of Interdisciplinary and Integrated Industrial Software Talent Cultivation Model”(JG2023-14)the Sichuan University Higher Education Teaching Reform Project(10th Phase)Research and Exploration of Practical Teaching Mode under the New Major Background of“Cross Disciplinary and Integration”(SCU10128)。
文摘To address the severe challenges posed by the international situation and meet the needs of the national major development strategies,the traditional software engineering talent cultivation model lacks interdisciplinary education focused on specific fields,making it difficult to cultivate engineering leaders with multidisciplinary backgrounds who are capable of solving complex real-world problems.To solve this problem,based on the decade-long interdisciplinary talent cultivation achievements of the College of Software Engineering at Sichuan University,this article proposes the“Software Engineering+”innovative talent cultivation paradigm.It provides an analysis through professional construction of interdisciplinary talents,the design of talent cultivation frameworks,the formulation of cultivation plans,the establishment of interdisciplinary curriculum systems,the reform of teaching modes,and the improvement of institutional systems.Scientific solutions are proposed,and five project models implemented and operated by the College of Software Engineering at Sichuan University are listed as practical examples,offering significant reference value.
基金funded by Universityindustry Collaborative Education Program(No.220605181024725)the Undergraduate Education and Teaching Reform Research Project of Northwestern Polytechnical University(No.22GZ13083)。
文摘With the rapid development of software engineering,traditional teaching methods are confronted with the challenges of short knowledge update cycles and the rapid emergence of new technologies.By analyzing the current situation of the mismatch between educational practices and industrial change,this study proposes an innovative teaching model—“Micro-practices”.This model integrates new knowledge and new technologies into the teaching process quickly and flexibly through practical teaching projects with“short class time,small capacity,and cloud environment”to meet the different educational needs of students,teachers,and enterprises.The aim is to train innovative software engineering talents who can meet the challenges of the future.
文摘Quantum software development utilizes quantum phenomena such as superposition and entanglement to address problems that are challenging for classical systems.However,it must also adhere to critical quantum constraints,notably the no-cloning theorem,which prohibits the exact duplication of unknown quantum states and has profound implications for cryptography,secure communication,and error correction.While existing quantum circuit representations implicitly honor such constraints,they lack formal mechanisms for early-stage verification in software design.Addressing this constraint at the design phase is essential to ensure the correctness and reliability of quantum software.This paper presents a formal metamodeling framework using UML-style notation and and Object Constraint Language(OCL)to systematically capture and enforce the no-cloning theorem within quantum software models.The proposed metamodel formalizes key quantum concepts—such as entanglement and teleportation—and encodes enforceable invariants that reflect core quantum mechanical laws.The framework’s effectiveness is validated by analyzing two critical edge cases—conditional copying with CNOT gates and quantum teleportation—through instance model evaluations.These cases demonstrate that the metamodel can capture nuanced scenarios that are often mistaken as violations of the no-cloning theorem but are proven compliant under formal analysis.Thus,these serve as constructive validations that demonstrate the metamodel’s expressiveness and correctness in representing operations that may appear to challenge the no-cloning theorem but,upon rigorous analysis,are shown to comply with it.The approach supports early detection of conceptual design errors,promoting correctness prior to implementation.The framework’s extensibility is also demonstrated by modeling projective measurement,further reinforcing its applicability to broader quantum software engineering tasks.By integrating the rigor of metamodeling with fundamental quantum mechanical principles,this work provides a structured,model-driven approach that enables traditional software engineers to address quantum computing challenges.It offers practical insights into embedding quantum correctness at the modeling level and advances the development of reliable,error-resilient quantum software systems.
文摘Building a collaborative education mechanism,improving students’engineering practice and innovation abilities,and cultivating software engineering innovation talents that meet industry needs are of great significance for fully implementing the“Excellent Engineer Education and Training Program”of the Ministry of Education and achieving the goal of building a strong engineering education country.The School of Information and Software Engineering of the University of Electronic Science and Technology of China(UESTC)has been thoroughly studying and implementing Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and the spirit of the 20th CPC National Congress.The school has steadfastly promoted the Project of Nurturing the Soul of the New Era.The school has taken moral education as its core,deeply explored the resources of“all staff,throughout the process,in all aspects”,and constructed and implemented the collaborative education mechanism.These efforts have laid a solid foundation for cultivating excellent talents in software engineering in the new era.
文摘Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,writing test cases,conducting functional and performance tests,and optimizing the product based on feedback.In government procurement projects,quality evaluation focuses on process compliance,security,and functional compatibility.KPI evaluation trees are commonly used for quantitative assessment,and a dynamic adjustment mechanism for indicators needs to be established to cope with complex demands.In addition,risk-driven testing and agile development should be combined to set up quality access control to ensure that each iteration version meets expectations.The multi-dimensional quality assurance and verification scoring mechanism can effectively enhance product reliability and reduce project risks.
文摘This paper presents a case study of the collaborative integration between the School of Information and Software Engineering at the University of Electronic Science and Technology of China(UESTC)and SI-TECH,highlighting the complementary advantages of both the University and the enterprise.By jointly establishing research institutes and engaging in diversified collaborative initiatives,the University and the enterprise have embarked on a pathway of School-enterprise Integration.Through a virtuous cycle of cooperation and continuous advancement,they have explored a comprehensive talent cultivation model in“5G”software engineering innovation practices based on this integration.Furthermore,this endeavor aims to facilitate the transformation of technological achievements and provides valuable insights for fostering innovative talents in the field of electronic information through enhanced integration between the University and the enterprise.
文摘This paper discusses the related contents of the integration application of information technology and computer software engineering.First,it briefly expounds the concepts and integration background of information technology and computer software engineering.Then,it deeply analyzes the application status and significance of the integration application of information technology and computer software engineering in different fields.Finally,it briefly describes the specific application paths of the integration of information technology and computer software engineering,hoping to provide some valuable references for promoting the in-depth integration and development of information technology and computer software engineering.
基金supported in part by the Education Reform Key Projects of Heilongjiang Province under Grant Nos.SJGZ20220011,SJGZ20220012,and SJGZY2024008。
文摘In response to the current issues in the construction of software engineering(SE)degree granting program,such as insufficient resource integration,low level of internationalization,and inadequate quality control,we propose the Software Engineering Degree Granting Program Construction Practice Project at Harbin Institute of Technology(HIT).This project aims to explore new models for software talent cultivation,establish a superior SE degree granting program,and ultimately cultivate outstanding internationalized composite SE professionals to support the high-quality development of the national software industry.To this end,we design a distinctive overall construction idea and plan for the SE degree granting program,which are characterized by“3I3S:three highlights for specialized cultivation and strictness in three aspects to ensure quality control”.After years of practice and validation of the project at the School of Software at HIT,this project has proven effective in optimizing talent cultivation models,enhancing students’practical abilities,promoting international exchange and cooperation,advancing industry-education integration,and meeting industrial needs.
基金supported in part by the Universityindustry Collaborative Education Program of the Ministry of Education under Grant No.202102383004。
文摘The advancement of Internet of Things(IoT)technology is driving industries toward intelligent digital transformation,highlighting the crucial role of software engineering.Despite this,the integration of software engineering into IoT engineering education remains underexplored.To address this gap,the School of Software at North University of China,in collaboration with QST Innovation Technology Group Co.,Ltd.(QST),has developed an innovative educational mechanism.This initiative focuses on the software engineering IoT track and optimizes the teaching process through the outcome-based education(OBE)concept.It incorporates military-industrial characteristics,introduces advanced information and technology curricula,and enhances laboratory infrastructure.The goal is to cultivate innovative talents with unique capabilities,thereby fostering the comprehensive development and application of IoT technology.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
基金supported by 2016 Shandong province undergraduate universities teaching reform research project:Exploration and practice of teaching reform and innovation mode of higher education based on MOOC (No.B2016Z018),Research and application of blended teaching mode based on MOOC+SPOCs+ flipped classroom(No.B2016Z020)teaching research project of 2016 Postgraduate Education Innovation Project in Shandong Province:Study on multidimensional education quality evaluation system for professional degree graduate students (SDYZ1603),research project of higher computer education:"Study of Staged Practice Education and Innovation Ability Development"(ER2016009),the Chinese National Supervisory Committee for the Education of Master of Engineering under Grant(No.2016-ZDn-6),Shandong Provincial Department of Education under Grant(No.SDYY14003) and teaching research project of Harbin Institute of Technology at Weihai (BK201602) as well
文摘Based on "MOOC + SPOC + Flipped Classroom", a particular blending teaching pattern adapting to MOOC teaching is proposed to strengthen software engineering students' abilities to study themselves and practice innovatively. Firstly, the process of MOOC development in China is introduced. The distinguishing feature and effect of MOOC teaching are analyzed, followed by the comparison with traditional class. The online Plus offline blending teaching pattern is the combination of online self-study on MOOC before class, seminar study of flipped classroom in class and the summary after class. With the demonstration of a typical case, a progressive strategy is given to implement blending teaching. Finally, the blending teaching pattern is assessed from multiple perspectives, of which both advantages and disadvantages are dissected. Through primary exploration, introducing online study and flipped classroom, blending teaching plays a positive role in software engineering teaching, which means traditional teaching pattern is changed. Meanwhile, students' innovative consciousness and practical ability are inspired. Nevertheless, new problems arise, so that intensive practice and improvement are necessary.
基金Under the auspices of National Natural Science Foundation of China(No.42293270)。
文摘Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
基金supported by the "Emerging Engineering Education" Research and Practice Project and the Key Project of Education and Teaching Reforms of Universities in Fujian Province (No.FBJG20180034)
文摘How to improve the employment of software engineering graduates, especially, how to effectively enhance the employment competitiveness of relevant overseas students in the context of "One Belt and One Road" is one of the core tasks of overseas Chinese universities. This paper proposes a reform plan for the practical training mode of school-enterprise cooperative project in the software engineering of overseas Chinese universities. The reform plan combines education concepts with practical research and development. It subdivides students and according to the characteristics of different types of students, and is carried out on campus, outside campus(in the province), and abroad(original area), which makes senior undergraduates fully understand the needs of enterprises, constantly improve their professional practice ability, and improve their competitiveness. Thus, the professional innovation and entrepreneurship ability of students is enhanced, and it also reduces the cost of employee entry.
文摘Practice is an important phase in the teaching of software engineering.How to improve students' practical ability is a common problem for many software colleges.The course of Software Project Practice is proposed to enhance students' practical skills.In this course,the students participate in the whole process of software development practice and take the exercise of entrepreneurial project development in their learning stage.
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
