In the era of exponential growth of digital information,recommender algorithms are vital for helping users navigate vast data to find relevant items.Traditional approaches such as collaborative filtering and contentba...In the era of exponential growth of digital information,recommender algorithms are vital for helping users navigate vast data to find relevant items.Traditional approaches such as collaborative filtering and contentbasedmethods have limitations in capturing complex,multi-faceted relationships in large-scale,sparse datasets.Recent advances in Graph Neural Networks(GNNs)have significantly improved recommendation performance by modeling high-order connection patterns within user-item interaction networks.However,existing GNN-based models like LightGCN and NGCF focus primarily on single-type interactions and often overlook diverse semantic relationships,leading to reduced recommendation diversity and limited generalization.To address these challenges,this paper proposes a dual multi-relational graph neural network recommendation algorithm based on relational interactions.Our approach constructs two complementary graph structures:a User-Item Interaction Graph(UIIG),which explicitly models direct user behaviors such as clicks and purchases,and a Relational Association Graph(RAG),which uncovers latent associations based on user similarities and item attributes.The proposed Dual Multi-relational Graph Neural Network(DMGNN)features two parallel branches that perform multi-layer graph convolutional operations,followed by an adaptive fusion mechanism to effectively integrate information from both graphs.This design enhances the model’s capacity to capture diverse relationship types and complex relational patterns.Extensive experiments conducted on benchmark datasets—including MovieLens-1M,Amazon-Electronics,and Yelp—demonstrate thatDMGNN outperforms state-of-the-art baselines,achieving improvements of up to 12.3%in Precision,9.7%in Recall,and 11.5%in F1 score.Moreover,DMGNN significantly boosts recommendation diversity by 15.2%,balancing accuracy with exploration.These results highlight the effectiveness of leveraging hierarchical multi-relational information,offering a promising solution to the challenges of data sparsity and relation heterogeneity in recommendation systems.Our work advances the theoretical understanding of multi-relational graph modeling and presents practical insights for developing more personalized,diverse,and robust recommender systems.展开更多
After a relation scheme R is decomposed into the set of schemes ρ={R_1,...,R_n},we may pose queries as if R existed in the database,taking a join of R_i's,when it is necessary to implement the query.Suppose a que...After a relation scheme R is decomposed into the set of schemes ρ={R_1,...,R_n},we may pose queries as if R existed in the database,taking a join of R_i's,when it is necessary to implement the query.Suppose a query involves a set of attributes S(?)R,we want to find the smallest subset of ρ whose union includes S.We prove that the problem is NP-complete and present a polynomial-bounded approximation algorithm.A subset of ρ whose union includes S and has a decomposition into 3NF with a lossless join and preservation of dependencies is given in the paper.展开更多
We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were use...We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with PCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.展开更多
This paper proposes a multi-criteria decision-making (MCGDM) method based on the improved single-valued neutrosophic Hamacher weighted averaging (ISNHWA) operator and grey relational analysis (GRA) to overcome the lim...This paper proposes a multi-criteria decision-making (MCGDM) method based on the improved single-valued neutrosophic Hamacher weighted averaging (ISNHWA) operator and grey relational analysis (GRA) to overcome the limitations of present methods based on aggregation operators. First, the limitations of several existing single-valued neutrosophic weighted averaging aggregation operators (i.e. , the single-valued neutrosophic weighted averaging, single-valued neutrosophic weighted algebraic averaging, single-valued neutrosophic weighted Einstein averaging, single-valued neutrosophic Frank weighted averaging, and single-valued neutrosophic Hamacher weighted averaging operators), which can produce some indeterminate terms in the aggregation process, are discussed. Second, an ISNHWA operator was developed to overcome the limitations of existing operators. Third, the properties of the proposed operator, including idempotency, boundedness, monotonicity, and commutativity, were analyzed. Application examples confirmed that the ISNHWA operator and the proposed MCGDM method are rational and effective. The proposed improved ISNHWA operator and MCGDM method can overcome the indeterminate results in some special cases in existing single-valued neutrosophic weighted averaging aggregation operators and MCGDM methods.展开更多
Objectives Clopidogrel is a prodrug that has to be converted to an active metabolite by hepatic cytochrome P450(CYP)isoenzymes to inhibit platelet aggregation.Individualvariability of platelet inhibition by clopidogre...Objectives Clopidogrel is a prodrug that has to be converted to an active metabolite by hepatic cytochrome P450(CYP)isoenzymes to inhibit platelet aggregation.Individualvariability of platelet inhibition by clopidogrel suggests a possibility for genetic factors having a significant influence on clopidogrel responsiveness.In this study,we sought to determine the association between the single nucleotide polymorphism of CYP 2C19681G】A and the occurrence of clopidogrel resistance(CR)in Chinese.Methods The study enrolled 614 hospitalized patients who underwentsuccessful percutaneouscoronary intervention with drug-eluting stents were received the treatmentwith dual antiplatelet regimen(aspirin plus clopidogrel).All patients received loading doses of 600 mg clopidogrel and 300 mg aspirin.20μmol/L ADP-induced platelet aggregation ratio(PAR)was assessed 24 h after clopi-dogrel administration.The maximum residual PAR≥70%was defined as CR.Genomic DNA was extracted from whole blood samples according to standard protocols,the single nucleotide polymorphism of the CYP2C19681G】A was genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in all the patients.Results CR was found in 126 patients(20.5%).There was CYP2C19681G】A polymorphism in the study population.The frequencies of the three kinds of genotypes(GG,GA,A A)in CR group and non-CR(NCR)group were 32.5%,47.6%,19.8%and 48.0%,45.0%,7.0%,respectively.The frequency of AA genotype was significantly higher in NCR group than that in CR group(OR=3.03,95%CI:1.889~5.784,P=0.003).The A allele carriers were more likely to develop clopidogrel resistance compared with that of G allele carriers(OR=1.85,95%CI:1.392~2.459,P=0.002).Conclusions CYP2C19681G/A polymorphism is associated with the risk of CR,and the A allele carriers may be a possible genetic susceptibility factor for patients with CR.展开更多
Since the beginning of European integration,the European Community has been committed to building an internal single market.Economically,it has been encouraging free competition,combating monopolies,and cautiously usi...Since the beginning of European integration,the European Community has been committed to building an internal single market.Economically,it has been encouraging free competition,combating monopolies,and cautiously using industrial policies.展开更多
Based on the mathematical model of quantum well laser diode(QW LDs) developed, the paper presents a relative intensity noise(RIN) model, which employs Gaussian form random noise with its average being to zero. It can ...Based on the mathematical model of quantum well laser diode(QW LDs) developed, the paper presents a relative intensity noise(RIN) model, which employs Gaussian form random noise with its average being to zero. It can be straightforwardly used to describe the effect of the noise on the performance of QW LDs. The RIN becomes notable in the frequency range of interests and therefore affects the device modulation property. The results are in good agreement of the published data. The RIN model proposed and the results can be used for purpose of device technique improvement and performance simulation of optical communication systems and networks.展开更多
Cognitive functions are often studied using eventrelated potentials（ERPs）that are usually estimated by an averaging algorithm.Clearly,estimation of single-trial ERPs can provide researchers with many more details of...Cognitive functions are often studied using eventrelated potentials（ERPs）that are usually estimated by an averaging algorithm.Clearly,estimation of single-trial ERPs can provide researchers with many more details of cognitive activity than the averaging algorithm.A novel method to estimate single-trial ERPs is proposed in this paper.This method includes two key ideas.First,singular value decomposition was used to construct a matrix,which mapped singletrial electroencephalographic recordings（EEG）into a low-dimensional vector that contained little information from the spontaneous EEG.Second,we used the theory of compressed sensing to build a procedure to restore single-trial ERPs from this low-dimensional vector.ERPs are sparse or approximately sparse in the frequency domain.This fact allowed us to use the theory of compressed sensing.We verified this method in simulated and real data.Our method and dVCA（differentially variable component analysis）,another method of single-trial ERPs estimation,were both used to estimate single-trial ERPs from the same simulated data.Results demonstrated that our method significantly outperforms dVCA under various conditions of signal-to-noise ratio.Moreover,the single-trial ERPs estimated from the real data by our method are statistically consistent with the theories of cognitive science.展开更多
The entanglement properties of the system of two two-level atoms interacting with a single-mode vacuum field are explored. The quantum entanglement between two two-level atoms and a single-mode vacuum field is investi...The entanglement properties of the system of two two-level atoms interacting with a single-mode vacuum field are explored. The quantum entanglement between two two-level atoms and a single-mode vacuum field is investigated by using the quantum reduced entropy; the quantum entanglement between two two-level atoms, and that between a single two-level atom and a single-mode vacuum field are studied in terms of the quantum relative entropy. The influences of the atomic dipole-dipole interaction on the quantum entanglement of the system are also discussed. Our results show that three entangled states of two atoms-field, atom-atom, and atom-field can be prepared via two two-level atoms interacting with a single-mode vacuum field.展开更多
In this paper, we discuss quantum uncertainty relations of quantum coherence through a different method from Ref. [52]. Some lower bounds with parameters and their minimal bounds are obtained. Moreover, we find that f...In this paper, we discuss quantum uncertainty relations of quantum coherence through a different method from Ref. [52]. Some lower bounds with parameters and their minimal bounds are obtained. Moreover, we find that for two pairs of measurement bases with the same maximum overlap, quantum uncertainty relations and lower bounds with parameters are different, but the minimal bounds are the same. In addition, we discuss the dynamics of quantum uncertainty relations of quantum coherence and their lower bounds under the amplitude damping channel（ADC）. We find that the ADC will change the uncertainty relations and their lower bounds, and their tendencies depend on the initial state.展开更多
In this paper,we discuss quantum uncertainty relations of Tsallis relative α entropy coherence for a single qubit system based on three mutually unbiased bases.For α∈[1/2,1)U(1,2],the upper and lower bounds of sums...In this paper,we discuss quantum uncertainty relations of Tsallis relative α entropy coherence for a single qubit system based on three mutually unbiased bases.For α∈[1/2,1)U(1,2],the upper and lower bounds of sums of coherence are obtained.However,the above results cannot be verified directly for any α∈(0,1/2).Hence,we only consider the special case of α=1/n+1,where n is a positive integer,and we obtain the upper and lower bounds.By comparing the upper and lower bounds,we find that the upper bound is equal to the lower bound for the special α=1/2,and the differences between the upper and the lower bounds will increase as α increases.Furthermore,we discuss the tendency of the sum of coherence,and find that it has the same tendency with respect to the different θ or φ,which is opposite to the uncertainty relations based on the Rényi entropy and Tsallis entropy.展开更多
The current research of compressed air engine（CAE） mainly focused on simulations and system integrations. However, energy efficiency and output torque of the CAE is limited, which restricts its application and popul...The current research of compressed air engine（CAE） mainly focused on simulations and system integrations. However, energy efficiency and output torque of the CAE is limited, which restricts its application and popularization. In this paper, the working principles of CAE are briefly introduced. To set a foundation for the study on the optimization of the CAE, the basic mathematical model of working processes is set up. A pressure-compensated valve which can reduce the inertia force of the valve is proposed. To verify the mathematical model, the prototype with the newly designed pressure-compensated intake valve is built and the experiment is carried out, simulation and experimental results of the CAE are conducted, and pressures inside the cylinder and output torque of the CAE are obtained. Orthogonal design and grey relation analysis are utilized to optimize structural parameters. The experimental and optimized results show that, first of all, pressure inside the cylinder has the same changing tendency in both simulation curve and experimental curve. Secondly, the highest average output torque is obtained at the highest intake pressure and the lowest rotate speed. Thirdly, the optimization of the single-cylinder CAE can improve the working efficiency from an original 21.95% to 50.1%, an overall increase of 28.15%, and the average output torque increases also increases from 22.047 5 N · m to 22.439 N · m. This research designs a single-cylinder CAE with pressure-compensated intake valve, and proposes a structural parameters design method which improves the single-cylinder CAE performance.展开更多
This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this c...This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this context remains an area of growing interest.We employ single-cell RNA sequencing analysis on renal tissues from 24 LN patients and 10 healthy controls.Leveraging the nonnegative matrix factorization(NMF)algorithm,we identified critical gene patterns and constructed 61 predictive models using a comprehensive suite of 12 machine learning algorithms.We developed a predictive model using 6 PRGs,enhanced by a LASSO plus Naive Bayes approach.展开更多
AIM： To systematically review the association between complement factors I （CFI） polymorphisms and age- related macular degeneration （AMD） and to explore whether CFI polymorphisms are associated with AMD, METHODS...AIM： To systematically review the association between complement factors I （CFI） polymorphisms and age- related macular degeneration （AMD） and to explore whether CFI polymorphisms are associated with AMD, METHODS： Meta-analysis of articles published from 1995 to January 2015 of articles involved with AMD and polymorphisms of the CFI gene. Eligible data were pooled in a Meta-analysis, analyzing using STATA software （version 12.0）, Review Manager （version 5.2） and different models based on the heterogeneity of effect sizes. Egger＇s test, Begg＇s rank correlation methods were used to evaluate for publication bias.~ RESULTS： Thirteen articles were eligible, describing two loci polymorphisms of the CFI gene （of which 12 articles focus on rs10033900T〉C and 3 articles focus on rs2285714C〉T）. For rs10033900T〉C, the results of our study revealed that having a mutant allele C, TC, CC and TC＋CC was associated with a decreased risk of AMD in all population groups studied （C versus T models, OR=0.84, 95%Ch 0.72-0.99, P=0.04; TC versus TT models OR= 0.89, 95%Ch 0.88-0.99, P=0.04;CC versus ＂1-1＂ models, OR=0.76, 95%Ch 0.60-0.98, P=-0.03; TC＋CC versus TT models, OR=0.81, 95%Ch0.65-0.99, P=0.04）. We found that C allele were related to lower AMD risk in the Caucasian population by subgroup analysis, but there was no association with AMD under the allele and genotypes comparison in Asian studies. For rs2285714 C〉T, the TC, TT genotypes contributed to a higher risk of AMD, compared with the CC carriers and CT＋CC （OR=1.34, 95%Ch 1.09-1.63, P=0.004; OR=1.50, 95%Ch 1.25-1.80, P〈0.0001）. CONCLUSION： This Meta-analysis suggests that CFI rs10033900T〉C and rs2285714C〉T polymorphisms may contribute to AMD.展开更多
AIM: To determine the association of gap junction protein alpha 3(GJA3) gene tag single-nucleotide polymorphisms(SNPs) with susceptibility to age-related cataract(ARC).METHODS: In total, 486 ARC patients were matched ...AIM: To determine the association of gap junction protein alpha 3(GJA3) gene tag single-nucleotide polymorphisms(SNPs) with susceptibility to age-related cataract(ARC).METHODS: In total, 486 ARC patients were matched with 500 healthy controls. All the participants underwent complete ophthalmic examinations. Haplotype-tagging SNPs of GJA3 gene were selected from the HapMap Beijing Han Chinese population. Genomic DNA was extracted from the peripheral blood leukocytes of all the subjects.Under three different genetic models: dominant, recessive,and additive, the association between SNPs and ARC was examined. After adjusting for age and sex, the genetic effects of the GJA3 SNPs were evaluated with logistic regression analysis.RESULTS: Four tag GJA3 SNPs(rs6490519, rs9506430,rs9509053, and rs9552089) were included in the present study. None of the SNPs showed a significant relationship with an altered risk of total ARC under the dominant,recessive, or additive models. In the subgroup analysis,rs9506430 had a significant effect on the formation of a posterior subcapsular cataract(P=0.002, OR: 0.227, 95%CI:0.088-0.590) under the recessive model.CONCLUSION: Our study indicates that GJA3 variants may influence the development of posterior subcapsular cataracts. Further studies need to be designed to confirm this possibility.展开更多
AIM:To explore the susceptible association between the insulin-like growth factor-1 receptor(IGF1 R)single nucleotide polymorphism(SNP)and age-related cataract(ARC),and investigate the underlying mechanisms in human l...AIM:To explore the susceptible association between the insulin-like growth factor-1 receptor(IGF1 R)single nucleotide polymorphism(SNP)and age-related cataract(ARC),and investigate the underlying mechanisms in human lens epithelium(HLE)cells.METHODS:Totally 1190 unrelated participants,comprising 690 ARC patients and 500 healthy individuals in Han Chinese population were recruited and genotyped for target SNP.Theχ2-test was used to detect genotypic distribution between the patient and control groups and the logistic regression was performed to adjust the age and gender.Meanwhile,different biological experimental methods,such as cell counting kit 8(CCK-8)assay,flow cytometry,quantitative real time polymerase chain reaction(Q-PCR)and Western blot,were used to detect cell viability,cell cycle progression and apoptosis in HLE cells or IGF1 R knockdown HLE cells.RESULTS:The rs1546713 in IGF1 R gene was identified(P=0.046,OR:1.606,95%CI:1.245-2.071),which shown a significant relevance with ARC risk under the dominant model.The results demonstrated that IGF1 R knockdown inhibited cell proliferation by inducing cell cycle arrested at S phase and promoting apoptosis.Mechanistically,the cell cycle blocked at S phase was linked with the alterations of cyclin A,cyclin B,cyclin E and P21.The pro-apoptosis function of IGF1 R may related with stimulating the activation of Caspase-3 and altering the expression levels of apoptotic proteins,including Bcl-2,Bax and Caspase-3.CONCLUSION:This study first report that IGF1 R polymorphisms may affect susceptibility to ARCs in Han Chinese population and provide new clues to understand the pathogenic mechanism of ARCs.Notably,IGF1 R is likely a potential target for ARC prevention and treatment.展开更多
AIM:To assess the association between age-related macular degeneration(AMD) and three single nucleotide polymorphisms(SNPS) related to the vascular endothelial growth factor(VEGF) gene.METHODS:The patients who were di...AIM:To assess the association between age-related macular degeneration(AMD) and three single nucleotide polymorphisms(SNPS) related to the vascular endothelial growth factor(VEGF) gene.METHODS:The patients who were diagnosed with AMD were included in this prospective study. Three SNPs(rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 controls.RESULTS:The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group(P =0.072 and P =0.058).However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type AMD(P =0.005 and P =0.010,respectively). One of the SNPs(rs1413711) was also found to be associated with the severity of AMD(P =0.001)with significant genotype distribution between early,intermediate, and advanced stages of the disease. The ancestral alleles were protective for both SNPs while the polymorphic alleles increased the risk for dry AMD.CONCLUSION:VEGF SNPs rs1413711 and rs2146323 polymorphisms are significantly associated with AMD subtypes in our population.展开更多
文摘In the era of exponential growth of digital information,recommender algorithms are vital for helping users navigate vast data to find relevant items.Traditional approaches such as collaborative filtering and contentbasedmethods have limitations in capturing complex,multi-faceted relationships in large-scale,sparse datasets.Recent advances in Graph Neural Networks(GNNs)have significantly improved recommendation performance by modeling high-order connection patterns within user-item interaction networks.However,existing GNN-based models like LightGCN and NGCF focus primarily on single-type interactions and often overlook diverse semantic relationships,leading to reduced recommendation diversity and limited generalization.To address these challenges,this paper proposes a dual multi-relational graph neural network recommendation algorithm based on relational interactions.Our approach constructs two complementary graph structures:a User-Item Interaction Graph(UIIG),which explicitly models direct user behaviors such as clicks and purchases,and a Relational Association Graph(RAG),which uncovers latent associations based on user similarities and item attributes.The proposed Dual Multi-relational Graph Neural Network(DMGNN)features two parallel branches that perform multi-layer graph convolutional operations,followed by an adaptive fusion mechanism to effectively integrate information from both graphs.This design enhances the model’s capacity to capture diverse relationship types and complex relational patterns.Extensive experiments conducted on benchmark datasets—including MovieLens-1M,Amazon-Electronics,and Yelp—demonstrate thatDMGNN outperforms state-of-the-art baselines,achieving improvements of up to 12.3%in Precision,9.7%in Recall,and 11.5%in F1 score.Moreover,DMGNN significantly boosts recommendation diversity by 15.2%,balancing accuracy with exploration.These results highlight the effectiveness of leveraging hierarchical multi-relational information,offering a promising solution to the challenges of data sparsity and relation heterogeneity in recommendation systems.Our work advances the theoretical understanding of multi-relational graph modeling and presents practical insights for developing more personalized,diverse,and robust recommender systems.
文摘After a relation scheme R is decomposed into the set of schemes ρ={R_1,...,R_n},we may pose queries as if R existed in the database,taking a join of R_i's,when it is necessary to implement the query.Suppose a query involves a set of attributes S(?)R,we want to find the smallest subset of ρ whose union includes S.We prove that the problem is NP-complete and present a polynomial-bounded approximation algorithm.A subset of ρ whose union includes S and has a decomposition into 3NF with a lossless join and preservation of dependencies is given in the paper.
文摘We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with Principal Component Analysis(PCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with PCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.
文摘This paper proposes a multi-criteria decision-making (MCGDM) method based on the improved single-valued neutrosophic Hamacher weighted averaging (ISNHWA) operator and grey relational analysis (GRA) to overcome the limitations of present methods based on aggregation operators. First, the limitations of several existing single-valued neutrosophic weighted averaging aggregation operators (i.e. , the single-valued neutrosophic weighted averaging, single-valued neutrosophic weighted algebraic averaging, single-valued neutrosophic weighted Einstein averaging, single-valued neutrosophic Frank weighted averaging, and single-valued neutrosophic Hamacher weighted averaging operators), which can produce some indeterminate terms in the aggregation process, are discussed. Second, an ISNHWA operator was developed to overcome the limitations of existing operators. Third, the properties of the proposed operator, including idempotency, boundedness, monotonicity, and commutativity, were analyzed. Application examples confirmed that the ISNHWA operator and the proposed MCGDM method are rational and effective. The proposed improved ISNHWA operator and MCGDM method can overcome the indeterminate results in some special cases in existing single-valued neutrosophic weighted averaging aggregation operators and MCGDM methods.
文摘Objectives Clopidogrel is a prodrug that has to be converted to an active metabolite by hepatic cytochrome P450(CYP)isoenzymes to inhibit platelet aggregation.Individualvariability of platelet inhibition by clopidogrel suggests a possibility for genetic factors having a significant influence on clopidogrel responsiveness.In this study,we sought to determine the association between the single nucleotide polymorphism of CYP 2C19681G】A and the occurrence of clopidogrel resistance(CR)in Chinese.Methods The study enrolled 614 hospitalized patients who underwentsuccessful percutaneouscoronary intervention with drug-eluting stents were received the treatmentwith dual antiplatelet regimen(aspirin plus clopidogrel).All patients received loading doses of 600 mg clopidogrel and 300 mg aspirin.20μmol/L ADP-induced platelet aggregation ratio(PAR)was assessed 24 h after clopi-dogrel administration.The maximum residual PAR≥70%was defined as CR.Genomic DNA was extracted from whole blood samples according to standard protocols,the single nucleotide polymorphism of the CYP2C19681G】A was genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in all the patients.Results CR was found in 126 patients(20.5%).There was CYP2C19681G】A polymorphism in the study population.The frequencies of the three kinds of genotypes(GG,GA,A A)in CR group and non-CR(NCR)group were 32.5%,47.6%,19.8%and 48.0%,45.0%,7.0%,respectively.The frequency of AA genotype was significantly higher in NCR group than that in CR group(OR=3.03,95%CI:1.889~5.784,P=0.003).The A allele carriers were more likely to develop clopidogrel resistance compared with that of G allele carriers(OR=1.85,95%CI:1.392~2.459,P=0.002).Conclusions CYP2C19681G/A polymorphism is associated with the risk of CR,and the A allele carriers may be a possible genetic susceptibility factor for patients with CR.
文摘Since the beginning of European integration,the European Community has been committed to building an internal single market.Economically,it has been encouraging free competition,combating monopolies,and cautiously using industrial policies.
文摘Based on the mathematical model of quantum well laser diode(QW LDs) developed, the paper presents a relative intensity noise(RIN) model, which employs Gaussian form random noise with its average being to zero. It can be straightforwardly used to describe the effect of the noise on the performance of QW LDs. The RIN becomes notable in the frequency range of interests and therefore affects the device modulation property. The results are in good agreement of the published data. The RIN model proposed and the results can be used for purpose of device technique improvement and performance simulation of optical communication systems and networks.
基金supported by National Basic Research Development Program (973 program) of China (2012CB825500,2011CB707800)National Natural Science Foundation of China (31271168)Natural Science Foundation of Fujian Province, China (2011J01344)
文摘Cognitive functions are often studied using eventrelated potentials（ERPs）that are usually estimated by an averaging algorithm.Clearly,estimation of single-trial ERPs can provide researchers with many more details of cognitive activity than the averaging algorithm.A novel method to estimate single-trial ERPs is proposed in this paper.This method includes two key ideas.First,singular value decomposition was used to construct a matrix,which mapped singletrial electroencephalographic recordings（EEG）into a low-dimensional vector that contained little information from the spontaneous EEG.Second,we used the theory of compressed sensing to build a procedure to restore single-trial ERPs from this low-dimensional vector.ERPs are sparse or approximately sparse in the frequency domain.This fact allowed us to use the theory of compressed sensing.We verified this method in simulated and real data.Our method and dVCA（differentially variable component analysis）,another method of single-trial ERPs estimation,were both used to estimate single-trial ERPs from the same simulated data.Results demonstrated that our method significantly outperforms dVCA under various conditions of signal-to-noise ratio.Moreover,the single-trial ERPs estimated from the real data by our method are statistically consistent with the theories of cognitive science.
基金Project supported by the National Natural Science Foundation of China （Grant No 10374025）.
文摘The entanglement properties of the system of two two-level atoms interacting with a single-mode vacuum field are explored. The quantum entanglement between two two-level atoms and a single-mode vacuum field is investigated by using the quantum reduced entropy; the quantum entanglement between two two-level atoms, and that between a single two-level atom and a single-mode vacuum field are studied in terms of the quantum relative entropy. The influences of the atomic dipole-dipole interaction on the quantum entanglement of the system are also discussed. Our results show that three entangled states of two atoms-field, atom-atom, and atom-field can be prepared via two two-level atoms interacting with a single-mode vacuum field.
基金Project supported by the National Natural Science Foundation of China(Grant No.11671244)the Higher School Doctoral Subject Foundation of Ministry of Education of China(Grant No.20130202110001)Fundamental Research Funds for the Central Universities,China(Grant No.2016CBY003)
文摘In this paper, we discuss quantum uncertainty relations of quantum coherence through a different method from Ref. [52]. Some lower bounds with parameters and their minimal bounds are obtained. Moreover, we find that for two pairs of measurement bases with the same maximum overlap, quantum uncertainty relations and lower bounds with parameters are different, but the minimal bounds are the same. In addition, we discuss the dynamics of quantum uncertainty relations of quantum coherence and their lower bounds under the amplitude damping channel（ADC）. We find that the ADC will change the uncertainty relations and their lower bounds, and their tendencies depend on the initial state.
基金This paper is supported by Startup Foundation for Doctors of Nanchang Hangkong University(No.EA201907210).
文摘In this paper,we discuss quantum uncertainty relations of Tsallis relative α entropy coherence for a single qubit system based on three mutually unbiased bases.For α∈[1/2,1)U(1,2],the upper and lower bounds of sums of coherence are obtained.However,the above results cannot be verified directly for any α∈(0,1/2).Hence,we only consider the special case of α=1/n+1,where n is a positive integer,and we obtain the upper and lower bounds.By comparing the upper and lower bounds,we find that the upper bound is equal to the lower bound for the special α=1/2,and the differences between the upper and the lower bounds will increase as α increases.Furthermore,we discuss the tendency of the sum of coherence,and find that it has the same tendency with respect to the different θ or φ,which is opposite to the uncertainty relations based on the Rényi entropy and Tsallis entropy.
基金Supported by National Natural Science Foundation of China(Grant Nos.51375028,51205008)
文摘The current research of compressed air engine（CAE） mainly focused on simulations and system integrations. However, energy efficiency and output torque of the CAE is limited, which restricts its application and popularization. In this paper, the working principles of CAE are briefly introduced. To set a foundation for the study on the optimization of the CAE, the basic mathematical model of working processes is set up. A pressure-compensated valve which can reduce the inertia force of the valve is proposed. To verify the mathematical model, the prototype with the newly designed pressure-compensated intake valve is built and the experiment is carried out, simulation and experimental results of the CAE are conducted, and pressures inside the cylinder and output torque of the CAE are obtained. Orthogonal design and grey relation analysis are utilized to optimize structural parameters. The experimental and optimized results show that, first of all, pressure inside the cylinder has the same changing tendency in both simulation curve and experimental curve. Secondly, the highest average output torque is obtained at the highest intake pressure and the lowest rotate speed. Thirdly, the optimization of the single-cylinder CAE can improve the working efficiency from an original 21.95% to 50.1%, an overall increase of 28.15%, and the average output torque increases also increases from 22.047 5 N · m to 22.439 N · m. This research designs a single-cylinder CAE with pressure-compensated intake valve, and proposes a structural parameters design method which improves the single-cylinder CAE performance.
基金supported by the Science and Technology Program for Basic Research in Shenzhen,Guangdong,China(No.JCYJ20200109140412476,JCYJ20190809095811254,GCZX2015043017281705)the Clinical Research Project in Shenzhen,Guangdong,China(No.20213357002,20213357028)+1 种基金the Team-based Medical Science Research Program in Shenzhen,Guangdong,China(No.2024YZZ06)Shenzhen High-level Hospital Construction Fund in Shenzhen,Guangdong,China(No.2024).
文摘This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this context remains an area of growing interest.We employ single-cell RNA sequencing analysis on renal tissues from 24 LN patients and 10 healthy controls.Leveraging the nonnegative matrix factorization(NMF)algorithm,we identified critical gene patterns and constructed 61 predictive models using a comprehensive suite of 12 machine learning algorithms.We developed a predictive model using 6 PRGs,enhanced by a LASSO plus Naive Bayes approach.
基金Supported by the Scientific Research Project of Traditional Chinese Medicine of Health and Family Planning Commission of Chongqing (ZY20150243)
文摘AIM： To systematically review the association between complement factors I （CFI） polymorphisms and age- related macular degeneration （AMD） and to explore whether CFI polymorphisms are associated with AMD, METHODS： Meta-analysis of articles published from 1995 to January 2015 of articles involved with AMD and polymorphisms of the CFI gene. Eligible data were pooled in a Meta-analysis, analyzing using STATA software （version 12.0）, Review Manager （version 5.2） and different models based on the heterogeneity of effect sizes. Egger＇s test, Begg＇s rank correlation methods were used to evaluate for publication bias.~ RESULTS： Thirteen articles were eligible, describing two loci polymorphisms of the CFI gene （of which 12 articles focus on rs10033900T〉C and 3 articles focus on rs2285714C〉T）. For rs10033900T〉C, the results of our study revealed that having a mutant allele C, TC, CC and TC＋CC was associated with a decreased risk of AMD in all population groups studied （C versus T models, OR=0.84, 95%Ch 0.72-0.99, P=0.04; TC versus TT models OR= 0.89, 95%Ch 0.88-0.99, P=0.04;CC versus ＂1-1＂ models, OR=0.76, 95%Ch 0.60-0.98, P=-0.03; TC＋CC versus TT models, OR=0.81, 95%Ch0.65-0.99, P=0.04）. We found that C allele were related to lower AMD risk in the Caucasian population by subgroup analysis, but there was no association with AMD under the allele and genotypes comparison in Asian studies. For rs2285714 C〉T, the TC, TT genotypes contributed to a higher risk of AMD, compared with the CC carriers and CT＋CC （OR=1.34, 95%Ch 1.09-1.63, P=0.004; OR=1.50, 95%Ch 1.25-1.80, P〈0.0001）. CONCLUSION： This Meta-analysis suggests that CFI rs10033900T〉C and rs2285714C〉T polymorphisms may contribute to AMD.
基金Supported by National Natural Science Foundation of China(No.81371000 No.81670834+4 种基金 No.81800807 No.81800869)the Natural Science Foundation of Zhejiang Province(No.LY17H090004)the Zhejiang Traditional Chinese Medicine Project(No.2013ZA080)the Fundamental Research Funds for the Central Universities(No.2018FZA7007)
文摘AIM: To determine the association of gap junction protein alpha 3(GJA3) gene tag single-nucleotide polymorphisms(SNPs) with susceptibility to age-related cataract(ARC).METHODS: In total, 486 ARC patients were matched with 500 healthy controls. All the participants underwent complete ophthalmic examinations. Haplotype-tagging SNPs of GJA3 gene were selected from the HapMap Beijing Han Chinese population. Genomic DNA was extracted from the peripheral blood leukocytes of all the subjects.Under three different genetic models: dominant, recessive,and additive, the association between SNPs and ARC was examined. After adjusting for age and sex, the genetic effects of the GJA3 SNPs were evaluated with logistic regression analysis.RESULTS: Four tag GJA3 SNPs(rs6490519, rs9506430,rs9509053, and rs9552089) were included in the present study. None of the SNPs showed a significant relationship with an altered risk of total ARC under the dominant,recessive, or additive models. In the subgroup analysis,rs9506430 had a significant effect on the formation of a posterior subcapsular cataract(P=0.002, OR: 0.227, 95%CI:0.088-0.590) under the recessive model.CONCLUSION: Our study indicates that GJA3 variants may influence the development of posterior subcapsular cataracts. Further studies need to be designed to confirm this possibility.
基金Supported by the National Natural Science Foundation of China(No.81670834,No.81970781,No.81800807,No.81800869)the Natural Science Foundation of Zhejiang Province(No.LY17H090004).
文摘AIM:To explore the susceptible association between the insulin-like growth factor-1 receptor(IGF1 R)single nucleotide polymorphism(SNP)and age-related cataract(ARC),and investigate the underlying mechanisms in human lens epithelium(HLE)cells.METHODS:Totally 1190 unrelated participants,comprising 690 ARC patients and 500 healthy individuals in Han Chinese population were recruited and genotyped for target SNP.Theχ2-test was used to detect genotypic distribution between the patient and control groups and the logistic regression was performed to adjust the age and gender.Meanwhile,different biological experimental methods,such as cell counting kit 8(CCK-8)assay,flow cytometry,quantitative real time polymerase chain reaction(Q-PCR)and Western blot,were used to detect cell viability,cell cycle progression and apoptosis in HLE cells or IGF1 R knockdown HLE cells.RESULTS:The rs1546713 in IGF1 R gene was identified(P=0.046,OR:1.606,95%CI:1.245-2.071),which shown a significant relevance with ARC risk under the dominant model.The results demonstrated that IGF1 R knockdown inhibited cell proliferation by inducing cell cycle arrested at S phase and promoting apoptosis.Mechanistically,the cell cycle blocked at S phase was linked with the alterations of cyclin A,cyclin B,cyclin E and P21.The pro-apoptosis function of IGF1 R may related with stimulating the activation of Caspase-3 and altering the expression levels of apoptotic proteins,including Bcl-2,Bax and Caspase-3.CONCLUSION:This study first report that IGF1 R polymorphisms may affect susceptibility to ARCs in Han Chinese population and provide new clues to understand the pathogenic mechanism of ARCs.Notably,IGF1 R is likely a potential target for ARC prevention and treatment.
基金Supported by Pamukkale University Scientific Research Unit(No.2011TPF025)
文摘AIM:To assess the association between age-related macular degeneration(AMD) and three single nucleotide polymorphisms(SNPS) related to the vascular endothelial growth factor(VEGF) gene.METHODS:The patients who were diagnosed with AMD were included in this prospective study. Three SNPs(rs1413711, rs2146323, and rs3025033) of the VEGF gene were genotyped by real-time polymerase chain reaction in the genomic DNA isolated from peripheral blood samples of the 82 patients and 80 controls.RESULTS:The genotype frequencies of rs1413711 and rs2146323 were not significantly different between the study group and the control group(P =0.072 and P =0.058).However, there was a significant difference in the genotype frequencies of these SNPs between the wet type AMD and dry type AMD(P =0.005 and P =0.010,respectively). One of the SNPs(rs1413711) was also found to be associated with the severity of AMD(P =0.001)with significant genotype distribution between early,intermediate, and advanced stages of the disease. The ancestral alleles were protective for both SNPs while the polymorphic alleles increased the risk for dry AMD.CONCLUSION:VEGF SNPs rs1413711 and rs2146323 polymorphisms are significantly associated with AMD subtypes in our population.
