Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can...Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.展开更多
Atom localization in a five-level atomic system under the effect of three driving fields and one standing wave field is suggested. A spontaneously emitted photon from the proposed system is measured in a detector. Pre...Atom localization in a five-level atomic system under the effect of three driving fields and one standing wave field is suggested. A spontaneously emitted photon from the proposed system is measured in a detector. Precision position measurement of an atom is controlled via phase and vacuum field detuning without considering the parity violation.展开更多
In order to solve the problem of landslide hazard to people in our country, this paper takes a landslide in Shanxi province as an example, based on BDS/GPS dual-frequency ionosphere-free combination Precise Point Posi...In order to solve the problem of landslide hazard to people in our country, this paper takes a landslide in Shanxi province as an example, based on BDS/GPS dual-frequency ionosphere-free combination Precise Point Positioning (PPP), and analyzes the reliability of BDS/GPS dual-frequency ionosphere-free combination PPP in landslide deformation monitoring from convergence time and three-dimensional deformation of landslide. The research results show that the convergence of BDS/GPS dual-frequency precise point positioning can achieve centimeter-level accuracy in the landslide environment. The convergence data can accurately measure the horizontal and vertical changes of the landslide, and can provide a strong basis and support for the disaster prevention of the landslide.展开更多
The floating point number is the most commonly used real number representation for digital computations due to its high precision characteristics. It is used on computers and on single chip applications such as DSP ch...The floating point number is the most commonly used real number representation for digital computations due to its high precision characteristics. It is used on computers and on single chip applications such as DSP chips. Double precision (64-bit) representations allow for a wider range of real numbers to be denoted. However, single precision (32-bit) operations are more efficient. Recently, there has been an increasing interest in mixed precision computations which take advantage of single precision efficiency on 64-bit numbers. This calls for the ability to interchange between the two formats. In this paper, an algorithm that converts floating point numbers from 64- to 32-bit representations is presented. The algorithm was implemented as a Verilog code and tested on field programmable gate array (FPGA) using the Quartus II DE2 board and Agilent 16821A portable logic analyzer. Results indicate that the algorithm can perform the conversion reliably and accurately within a constant execution time of 25 ns with a 20 MHz clock frequency regardless of the number being converted.展开更多
BeiDou regional navigation satellite system （BDS） also called BeiDou-2 has been in full operation since December 27, 2012. It consists of 14 satellites, including 5 satellites in Geostationary Orbit （GEO）, 5 satel...BeiDou regional navigation satellite system （BDS） also called BeiDou-2 has been in full operation since December 27, 2012. It consists of 14 satellites, including 5 satellites in Geostationary Orbit （GEO）, 5 satellites in Inclined Geosynchronous Orbit （IGSO）, and 4 satellites in Medium Earth Orbit （MEO）. In this paper, its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing, including satellite visibility, Position Dilution of Precision （PDOP） value, the precision of code and carrier phase measurements, the accuracy of single point positioning and differential position- ing and ambiguity resolution （AR） performance, which are also compared with those of GPS. It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm, respectively, which are comparable to those of GPS, and the accuracy of BDS single point positioning has satisfied the design requirement. The real-time kinematic positioning is also feasible by BDS alolae in the opening condition, since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS. The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km, which is on the same level with that of GPS. For the combined BDS and GPS, the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly. The accu- racy of BDS/GPS carrier phase differential positioning is about 35 and 20 % better than that of GPS for two short baseline tests in this study. The accuracy of BDS code differential positioning is better than 2.5 m. However it is worse than that of GPS, which may result from large code multipath errors of BDS GEO satellite measurements.展开更多
基金Supported in part by NIH Heart,Lung,and Blood Institute(No.HLO74815)Institute of Neurological Disorders and Stroke(No.NS-084823)
文摘Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.
文摘Atom localization in a five-level atomic system under the effect of three driving fields and one standing wave field is suggested. A spontaneously emitted photon from the proposed system is measured in a detector. Precision position measurement of an atom is controlled via phase and vacuum field detuning without considering the parity violation.
文摘In order to solve the problem of landslide hazard to people in our country, this paper takes a landslide in Shanxi province as an example, based on BDS/GPS dual-frequency ionosphere-free combination Precise Point Positioning (PPP), and analyzes the reliability of BDS/GPS dual-frequency ionosphere-free combination PPP in landslide deformation monitoring from convergence time and three-dimensional deformation of landslide. The research results show that the convergence of BDS/GPS dual-frequency precise point positioning can achieve centimeter-level accuracy in the landslide environment. The convergence data can accurately measure the horizontal and vertical changes of the landslide, and can provide a strong basis and support for the disaster prevention of the landslide.
文摘The floating point number is the most commonly used real number representation for digital computations due to its high precision characteristics. It is used on computers and on single chip applications such as DSP chips. Double precision (64-bit) representations allow for a wider range of real numbers to be denoted. However, single precision (32-bit) operations are more efficient. Recently, there has been an increasing interest in mixed precision computations which take advantage of single precision efficiency on 64-bit numbers. This calls for the ability to interchange between the two formats. In this paper, an algorithm that converts floating point numbers from 64- to 32-bit representations is presented. The algorithm was implemented as a Verilog code and tested on field programmable gate array (FPGA) using the Quartus II DE2 board and Agilent 16821A portable logic analyzer. Results indicate that the algorithm can perform the conversion reliably and accurately within a constant execution time of 25 ns with a 20 MHz clock frequency regardless of the number being converted.
基金sponsored by the National Natural Science Foundation of China(Grant Nos.41020144004,41374019,41104022)the National High Technology Research and Development Program of China(Grant No.2013AA122501)
文摘BeiDou regional navigation satellite system （BDS） also called BeiDou-2 has been in full operation since December 27, 2012. It consists of 14 satellites, including 5 satellites in Geostationary Orbit （GEO）, 5 satellites in Inclined Geosynchronous Orbit （IGSO）, and 4 satellites in Medium Earth Orbit （MEO）. In this paper, its basic navigation and positioning performance are evaluated preliminarily by the real data collected in Beijing, including satellite visibility, Position Dilution of Precision （PDOP） value, the precision of code and carrier phase measurements, the accuracy of single point positioning and differential position- ing and ambiguity resolution （AR） performance, which are also compared with those of GPS. It is shown that the precision of BDS code and carrier phase measurements are about 33 cm and 2 mm, respectively, which are comparable to those of GPS, and the accuracy of BDS single point positioning has satisfied the design requirement. The real-time kinematic positioning is also feasible by BDS alolae in the opening condition, since its fixed rate and reliability of single-epoch dual-frequency AR is comparable to those of GPS. The accuracy of BDS carrier phase differential positioning is better than 1 cm for a very short baseline of 4.2 m and 3 cm for a short baseline of 8.2 km, which is on the same level with that of GPS. For the combined BDS and GPS, the fixed rate and reliability of single-epoch AR and the positioning accuracy are improved significantly. The accu- racy of BDS/GPS carrier phase differential positioning is about 35 and 20 % better than that of GPS for two short baseline tests in this study. The accuracy of BDS code differential positioning is better than 2.5 m. However it is worse than that of GPS, which may result from large code multipath errors of BDS GEO satellite measurements.
