Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements ...Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements in treatment,including insulin therapy and glucose monitoring devices,diabetes continues to significantly impact quality of life and current modalities do not reverse the end-organ damage associated with its progression.While traditionally indicated for type 1 diabetes,recent clinical practice refinements have made pancreas transplants available to select type 2 diabetics meeting specific criteria.These transplants are usually a part of a simultaneous kidney-pancreas transplant.However,although less frequently performed,transplants of pancreas alone or pancreas after kidney transplant are still available.For selected diabetic patients,pancreas transplants offer significant survival benefits and the improvement of cardiovascular and metabolic complications;however,they are not without risks.Complications such as bleeding,vascular thrombosis,infection,organ leak,and rejection are possible.Another challenge to pancreas transplantation is the decreasing number of procedures being performed due to decline in the volume of available highquality allografts and resource constraints of transplant centers.Advancements in monitoring and treatment of diabetes are contributing to the decline in pancreas transplants nowadays.展开更多
Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefor...Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development.展开更多
The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alon...The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.展开更多
Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheles...Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheless,these works predominantly centered on the formation and utilization of hydroxyl radicals(•OH)in the process,neglecting the evolution of oxidant and reductant due to the difficulty in the simultaneous determination of these two components.By employing the quenching-iodometric method,we could simultaneously determine the concentrations of HSO_(3)-and peroxydisulfate(PDS).This method first employed an excess of peroxymonosulfate(PMS)to effectively quench HSO_(3)-,and then used the iodometric spectrophotometry to simultaneously determine the concentrations of PMS and PDS in the reaction system.Finally,through precise stoichiometric relationships,we could accurately calculate the concentration of HSO_(3)-.Based on this method,we achieved concentration measurements that,upon linear fitting,yielded a correlation coefficient(R^(2))surpassing 0.99,unequivocally affirming the method’s accuracy and trustworthiness.In this work,an innovation approach for determining the concentrations of HSO_(3)-(reductant)and PDS(oxidant)was explored.Additionally,the resilience of the method was verified across different pH levels and in the presence of diverse impurity ions.The results ensured precise concentration measure-ments in the real wastewater.This method was characterized by its simplicity,rapid analysis,and environmental friendliness,offering a newanalytical strategy for the determination of PDS and HSO_(3)-in environmental samples.The method enables more meticulous monitoring of chemical usage in water treatment,facilitating optimized dosing strategies and assessments of reductant-enhanced Fenton or Fenton-like system in water purification.展开更多
Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost...Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost-effective magnetic biochar adsorbent (ITBNa800was prepared using biomass waste and iron tailings slag.This composite adsorbent exhibits excellent performance in the simultaneous removal of aqueous As(Ⅴ) and Cd(Ⅱ) even at high concentrations with removal efficiencies of up to 99.98%and 96.04%,respectively.Electro static action,precipitation,and complexation were adsorption mechanisms.As(Ⅴ) and Cd(Ⅱ were synergistic and competitive adsorption.As(Ⅴ) removal was mainly due to physical and chemical adsorption,and 42.40%-58.59%of As(Ⅴ) had been converted to As(Ⅲ ).Cd(Ⅱ) re moval was mainly due to chemical adsorption.Iron oxide and aluminum oxide in ITBNa800were the keys to As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) adsorption.DFT calculations revealed iron oxide complex As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) molecular clusters through bidentate binuclear,bidentate binuclear,and monodentate binuclear pathways,respectively.Aluminum oxide complex Cd(Ⅱ) molecular cluster through a bidentate mononuclear pathway.We hope the ITBNa800adsorbent and its involved mechanism could offer inspiration in the simultaneous treat ment of As and Cd pollution.展开更多
Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address th...Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address this issue,we propose a geometric error cost sensitivity-based accuracy allocation method for five-axis machine tools.A geometric error model consisting of 4l error components is constructed based on homogeneous transformation matrices.Volumetric points with positional and tool direction deviations are randomly sampled to evaluate the accuracy of the machine tool.The sensitivity of each error component at these sampling points is analyzed using the Sobol method.To balance the needs of geometric precision and manufacturing cost,a geometric error cost sensitivity function is developed to estimate the required cost.By allocating error components affecting tool direction deviation first and the remaining components second,this allocation scheme ensures that both deviations meet the requirements.We also perform numerical simulation of a BC-type(B-axis and C-axis type)five-axis machine tool to validate the method.The results show that the new allocation scheme reduces the total geometric error cost by 27.8%compared to a uniform allocation scheme,and yields the same positional and tool direction machining accuracies.展开更多
The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single react...The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.展开更多
The complex working environment of distribution networks tends to cause impermanent single-phase-to-ground(SPG)fault,and high-temperature ground fault arc is prone to endanger lives and power equipment,resulting in la...The complex working environment of distribution networks tends to cause impermanent single-phase-to-ground(SPG)fault,and high-temperature ground fault arc is prone to endanger lives and power equipment,resulting in large-scale power outages and fire accidents.Thus,fault arc should be extinguished in time.Meanwhile,stable operation conditions of distribution networks and reliable load power supply should be guaranteed to provide high-quality customer service.This paper proposes an active mitigation strategy for SPG fault,and provide active and reactive power compensation at the same time by utilizing an improved flexible power electronic equipment(FPEE)with dc-link sources.These controls are decoupled from each other,so utilization of FPEE is maximized as much as possible.When a SPG fault occurs in distribution networks,FPEE can output,simultaneously,active power,reactive power,and SPG fault compensation current by controlling output current on the d,q,0 coordinate system,respectively.During normal operation of distribution networks,the FPEE can be used as a virtual synchronous generator to compensate load power and its fluctuation.The proposed simultaneous multi-function can also be applied in other cases.Simulation cases are implemented to verify principles and practicability.展开更多
A temperature and acoustic impedance simultaneous sensor based on forward stimulated Brillouin scattering(FSBS)in highly nonlinear fiber(HNLF)with high sensitivity and high accuracy is proposed and demonstrated in thi...A temperature and acoustic impedance simultaneous sensor based on forward stimulated Brillouin scattering(FSBS)in highly nonlinear fiber(HNLF)with high sensitivity and high accuracy is proposed and demonstrated in this paper.High-order acoustic modes(HOAMs)are used to achieve individual or simultaneous measurement of the two parameters.Transverse acoustic waves(TAWs)involved in the FSBS process can efficiently sense the mechanical or environmental changes outside the fiber cladding,which will be reflected in a linear shift of the acoustic resonance frequency.By analyzing the frequencies of specific scattering peaks,the temperature and acoustic impedance outside the fiber cladding can be obtained simultaneously.The highest measured temperature and acoustic impedance sensitivities are 184.93 k Hz/℃and444.56 k Hz/MRayl,and the measurement accuracies are 0.09℃and 0.009 MRayl,respectively,which are both at desirable levels.We believe this work can provide potential application solutions for sensing fields involving temperature or acoustic impedance measurements.展开更多
The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.A...The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.As a primary thermal analysis instrument,the simultaneous thermal analyzer(STA)has unique advantages,which combines the functionalities of thermogravimetric(TG)analyzersand differential scanning calorimeters(DSC).However,the absence of standard quality control procedures has resulted in poor measurement reproducibility,low accuracy,and inadequate traceability of analytical results.This study utilized a multi-point temperature calibration method based on national certified reference materials to reduce instrument temperature indication errors.On this basis,we innovatively established a comprehensive quality control system encompassing laboratory environmental control,standard method selection,instrument performance verification,reference material traceability,and uncertainty analysis,thereby achieving standardized operational procedures for thermal analysis measurement.Taking the"determination of initial melting temperature of unknown substances"as a representative case study,a component resolution model for thermal analysis test uncertainty was developed.Through systematic analysis of both the reference material-introduced component and measurement repeatability component,complete traceability of test results was achieved.This approach ensures data validity and enhances the accuracy of test results.This provides crucial technical support and practical reference for the standardization of thermal analysis measurement procedure and assessment of result reliability.展开更多
Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electron...Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electronic Engi-neering,Hengyang Normal University,Hengyang 421008,China’but should have been‘School of Nuclear Science and Technology,University of South China,Hengyang 421001,China’.The original article has been corrected.展开更多
A sudden increase in the radial depth(SIRD)is a distinctive phenomenon in plunge milling.It is typically characterized by a sharp increase in cutting force at the end of the axial feed of the tool,accompanied by harsh...A sudden increase in the radial depth(SIRD)is a distinctive phenomenon in plunge milling.It is typically characterized by a sharp increase in cutting force at the end of the axial feed of the tool,accompanied by harsh machine vibration sounds,which can negatively impact the reliability of plunge milling.This paper proposes an optimization method to eliminate SIRD in five-axis plunge milling.Initially,a five-axis plunge milling experiment and an analysis of the spatial position relationship between the plunge tools and the workpiece revealed that the cause of SIRD is unreasonable tool path planning.Subsequently,using the cutter position and cutter axis vector as variables,an SIRD discrimination model was developed for adjacent cutter positions and extended to multiple cutter positions.Optimizing the plunge milling tool path is considered a multivariate optimization problem that involves determining the cutter point and cutter axis vector.The SIRD discrimination model was used as a constraint function to aid in solving for the variables.The simulation and experimental results indicate that with the remaining volume of material as the optimization target,the optimized plunge milling tool path results in a residual material volume that is less than 60%of the gradually decreasing plunge depth.This optimization decreases the subsequent semi-finishing time of the workpiece and enhances machining efficiency.Additionally,it does not rely on operator experience and facilitates efficient automated optimization of the tool path to exclude SIRD.展开更多
Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultan...Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultaneous resistance and color responses are designed and prepared.The conductive core is consisted of interconnected liquid metal nanodroplets dispersed in a polymer matrix and the elastomer shell is made of cholesteric liquid crystals.When stretched,the fiber resistance increases as the interconnected pathways of liquid metal nanodroplets along the fiber axis become narrower,and the selective reflection color from the fiber surface blueshifts since the cholesteric pitch decreases.The smart elastomer fibers could be woven into smart textiles and respond to various mechanical deformations,including stretching,bending,compression and twisting.The average resistance change is 51%under 100%strain and its variation is smaller than 4%over 500 cycles,showing remarkable fatigue resistance.The simultaneous resistance and color responses to mechanical deformations make the fibers attractive for broad applications,such as flexible electronics.展开更多
The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ens...The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ensuring the seamless execution of the forum’s translation necessitated exceptionally high standards for simultaneous interpreters.This paper,through the lens of the Translation as Adaptation and Selection theory within Eco-Translatology,conducts an analytical study of the live simultaneous interpretation at the First Multidisciplinary Forum on COVID-19.It examines the interpreters’adaptations and selections across multiple dimensions-namely,linguistic,cultural,and communicative-with the aim of elucidating the guiding role and recommendations that Eco-Translatology can offer to simultaneous interpretation.Furthermore,it seeks to provide insights that may enhance the quality of interpreters’oral translations.展开更多
BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE...BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.展开更多
Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously ...Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously remove nitrate and phosphate cost-effectively,but its nitrate rate is slow.So,iron sulfide mineral/polylactic acid mixotrophic biofilter(ISPLAB)was constructed to combine advantages of ISAD and PLAHD.ISPLAB achieved nitrogen and phosphorus removal rates of 98.04%and 94.12%,respectively,at a hydraulic retention time(HRT)of 24 h.The study also revealed that controlling molecular weight(MW)of PLA improved the release of soluble organic matter;adding iron sulfide enhanced the hydrolysis of PLA and precipitated PO_(4)^(3-) of Fe^(2+)/Fe^(3+),thereby facilitated simultaneous nitrogen and phosphorus removal.Microbial community analysis resulted that denitrifying bacterias(Phaeodactylibacter and Methylotenera),sulfur-reducing bacterias(Hyphomicrobium),sulfur-oxidizing bacteria(Denitratisoma),iron-reducing bacteria(Romboutsia)and hydrolyzed bacterias(norank_f_norank_o_1-20 and norank_f_Caldilineaceae)coexisted in the ISPLAB system.Organics and iron sulfide drived the denitrification process in ISPLAB.展开更多
DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide ...DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide convincing evidence based on the comparison of the activity of multiple enzymes than on that of single enzyme.Although fluorescence approach has been applied for the simultaneous detection both of DNA repair enzymes,the spectral overlap and multiwavelength excitation severely restrict the number of available fluorophores.Thus,it is difficult to simultaneously detect three enzymes in a single analysis by fluorescence detection.Herein,we developed a method for the simultaneous determination of three DNA repair enzymes including human flap DNA endonuclease 1(FEN1),human alkyladenine DNA glycosylase(hAAG)and uracil DNA glycosylase(UDG)based on the combination of template-free amplification system with capillary electrophoresis-laser induced fluorescence(CE-LIF)detection.The amplification system was adopted to transfer and amplify the enzymatic products into different length DNA fragments which could be separated effectively by CE-LIF without the complicated modification of the capillary inner wall or labeling different tails on signal probes for separation.The method demonstrated a detection limit of 0.07 U/mL(0.08-160 U/mL)for FEN1,2.40 U/mL(2.5-250U/mL)for hAAG and 2.1×10^(-4)U/mL(0.0004-2.5 U/mL)for UDG,the relative standard deviations(RSDs)of peak time and peak area for different analytes were as follows:2.50%-4,37%and 3.24%-7.18%(inter-day);1.37%-2.71%and 1.43%-3.02%(intra-day),4.28%-6.08%and 4.16%-7.57%(column to column),respectively.And it can identify the inhibitor-like drugs,evaluate enzymatic kinetics and achieve the detection of three enzymes in cell extracts,providing a simple and powerful platform for simultaneous detection of more DNA repair enzymes.展开更多
Blended acquisition offers efficiency improvements over conventional seismic data acquisition, at the cost of introducing blending noise effects. Besides, seismic data often suffers from irregularly missing shots caus...Blended acquisition offers efficiency improvements over conventional seismic data acquisition, at the cost of introducing blending noise effects. Besides, seismic data often suffers from irregularly missing shots caused by artificial or natural effects during blended acquisition. Therefore, blending noise attenuation and missing shots reconstruction are essential for providing high-quality seismic data for further seismic processing and interpretation. The iterative shrinkage thresholding algorithm can help obtain deblended data based on sparsity assumptions of complete unblended data, and it characterizes seismic data linearly. Supervised learning algorithms can effectively capture the nonlinear relationship between incomplete pseudo-deblended data and complete unblended data. However, the dependence on complete unblended labels limits their practicality in field applications. Consequently, a self-supervised algorithm is presented for simultaneous deblending and interpolation of incomplete blended data, which minimizes the difference between simulated and observed incomplete pseudo-deblended data. The used blind-trace U-Net (BTU-Net) prevents identity mapping during complete unblended data estimation. Furthermore, a multistep process with blending noise simulation-subtraction and missing traces reconstruction-insertion is used in each step to improve the deblending and interpolation performance. Experiments with synthetic and field incomplete blended data demonstrate the effectiveness of the multistep self-supervised BTU-Net algorithm.展开更多
This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing opti...This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing optimization model is developed based on the operational requirements of the KS Logistics Center,focusing on minimizing vehicle dispatch,loading and unloading,operating,and time window penalty costs.The model incorporates constraints such as vehicle capacity,time windows,and travel distance,and is solved using a genetic algorithm to ensure optimal route planning.Through MATLAB simulations,34 customer points are analyzed,demonstrating that the simultaneous pickup and delivery model reduces total costs by 30.13%,increases vehicle loading rates by 20.04%,and decreases travel distance compared to delivery-only or pickup-only models.The results demonstrate the significant advantages of the simultaneous pickup and delivery mode in reducing logistics costs and improving vehicle utilization,offering valuable insights for enhancing the operational efficiency of the KS Logistics Center.展开更多
BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and com...BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and comprehensive complication index(CCI)in predicting outcomes after SPK.METHODS Data for patients undergoing SPK between 1999-2019 were analyzed.Information on recipients’baseline characteristics,peri-operative management and postoperative complications were collated.Length of hospital stay(LOS)was the primary study outcome,and the associations with CDC and CCI were evaluated using Spearman’s(ρ)correlation coefficients.RESULTS In the study period,data were available for 128 patients(female n=44,34.4%).Sixty-nine patients had at least one complication with the highest CDC grade of I,II,III,and IV in 8(6.3%),22(17.2%),32(25%),and 7(5.5%)patients,respectively. The mean LOS was 21.4 ± 17.7 days. Both classification systems were correlated with LOS, yet CCI was stronger(Spearman’s ρ: 0.694 vs 0.602, P < 0.001). Female patients (P = 0.019) and patients with pre-transplant cardiovascularevents (P = 0.02) had longer LOS. After adjusted multivariable analysis, the link between LOS and both theCDC and CCI remained relevant. CCI had a superior fit compared to CDC (r2 = 0.729 vs r2 = 0.481), with every 10CCI points being associated with a 5.27 day (P < 0.001) increased LOS.CONCLUSIONThis study showed that the CCI was better linked with LOS compared to CDC and might represent a useful scoreto evaluate the overall burden of postoperative complications in patients undergoing SPK.展开更多
文摘Diabetes is a widespread disease affecting millions of people,making it one of the leading causes of death in the world.It is a leading cause of cardiovascular disease and end-stage renal disease.Despite advancements in treatment,including insulin therapy and glucose monitoring devices,diabetes continues to significantly impact quality of life and current modalities do not reverse the end-organ damage associated with its progression.While traditionally indicated for type 1 diabetes,recent clinical practice refinements have made pancreas transplants available to select type 2 diabetics meeting specific criteria.These transplants are usually a part of a simultaneous kidney-pancreas transplant.However,although less frequently performed,transplants of pancreas alone or pancreas after kidney transplant are still available.For selected diabetic patients,pancreas transplants offer significant survival benefits and the improvement of cardiovascular and metabolic complications;however,they are not without risks.Complications such as bleeding,vascular thrombosis,infection,organ leak,and rejection are possible.Another challenge to pancreas transplantation is the decreasing number of procedures being performed due to decline in the volume of available highquality allografts and resource constraints of transplant centers.Advancements in monitoring and treatment of diabetes are contributing to the decline in pancreas transplants nowadays.
基金Under the auspices of the National Natural Science Foundation of China(No.42371222,41971167)Fundamental Scientific Research Funds of Central China Normal University(No.CCNU24ZZ120)。
文摘Owing to intensified globalization and informatization,the structures of the urban scale hierarchy and urban networks between cities have become increasingly intertwined,resulting in different spatial effects.Therefore,this paper analyzes the spatial interaction between urban scale hierarchy and urban networks in China from 2019 to 2023,drawing on Baidu migration data and employing a spatial simultaneous equation model.The results reveal a significant positive spatial correlation between cities with higher hierarchy and those with greater network centrality.Within a static framework,we identify a positive interaction between urban scale hierarchy and urban network centrality,while their spatial cross-effects manifest as negative neighborhood interactions based on geographical distance and positive cross-scale interactions shaped by network connections.Within a dynamic framework,changes in urban scale hierarchy and urban networks are mutually reinforcing,thereby widening disparities within the urban hierarchy.Furthermore,an increase in a city’s network centrality had a dampening effect on the population growth of neighboring cities and network-connected cities.This study enhances understanding of the spatial organisation of urban systems and offers insights for coordinated regional development.
基金supported by Major Scientific and Technological Innovation Project of Shandong Province(No.2020CXGC011204)Qingdao Natural Science Foundation(No.23-2-1-234-zyyd-jch).
文摘The coexistence of emerging containments,such as antibiotic resistant bacteria(ARB),antibiotic-resistant genes(ARGs)and antibiotics,potentially influence elimination efficiencies in UV light-emitting diode(UV-LED)alone and UV-LED/H_(2)O_(2) system as their complex interactions.Tetracycline(TC)degradation efficiency(kF)correlated closely with its UV molar absorbance(R^(2)=0.831)in UV-LED alone system and with·OH yield(R^(2)=0.999)in UV-LED/H_(2)O_(2) system across studied wavelengths(265,280 and 310 nm).The kF values for intracellular DNA(i-ARGs)also exhibited a high correlation with UV-LED wavelengths in both systems(R^(2)=0.997-0.999).The coexistence of TC and ARB/ARGs resulted in a mutual inhibition of their degradation efficiencies due to competition for photons and·OH,along with the consequent reduction in intracellular ROS within ARB,with their degradation efficiencies exhibiting marked dependence on wavelength in both systems.Notably,the UV-LED/H_(2)O_(2) system at 265 nm effectively achieved the simultaneous removal of TC,ARB and ARGs with minimal energy consumption,and successfully fragmented ARGs.The degradation pathway of TC was analyzed,and the biotoxicity of its degradation intermediates demonstrated the environmental friendliness and safety of UV-LED/H_(2)O_(2) technology.This study elucidated the competitive interactions between antibiotics and ARB/ARGs within UV-LED/H_(2)O_(2) system,providing a promising approach for their simultaneous removal while ensuring energy efficiency.
基金supported by National Natural Scienc Foundation of China(No.52400097)the Nanqiang Young Talents Supporting Program from Xiamen University.
文摘Fenton/Fenton-like reactions have gained popularity for their remarkable proficiency in decomposing organic pollutants,especially when enhanced by reductants addition for accel-erating the Fe2+regeneration.Nevertheless,these works predominantly centered on the formation and utilization of hydroxyl radicals(•OH)in the process,neglecting the evolution of oxidant and reductant due to the difficulty in the simultaneous determination of these two components.By employing the quenching-iodometric method,we could simultaneously determine the concentrations of HSO_(3)-and peroxydisulfate(PDS).This method first employed an excess of peroxymonosulfate(PMS)to effectively quench HSO_(3)-,and then used the iodometric spectrophotometry to simultaneously determine the concentrations of PMS and PDS in the reaction system.Finally,through precise stoichiometric relationships,we could accurately calculate the concentration of HSO_(3)-.Based on this method,we achieved concentration measurements that,upon linear fitting,yielded a correlation coefficient(R^(2))surpassing 0.99,unequivocally affirming the method’s accuracy and trustworthiness.In this work,an innovation approach for determining the concentrations of HSO_(3)-(reductant)and PDS(oxidant)was explored.Additionally,the resilience of the method was verified across different pH levels and in the presence of diverse impurity ions.The results ensured precise concentration measure-ments in the real wastewater.This method was characterized by its simplicity,rapid analysis,and environmental friendliness,offering a newanalytical strategy for the determination of PDS and HSO_(3)-in environmental samples.The method enables more meticulous monitoring of chemical usage in water treatment,facilitating optimized dosing strategies and assessments of reductant-enhanced Fenton or Fenton-like system in water purification.
基金supported by the National Natural Science Foundation of China(NSFC)grants(Nos.41473122,41173113,52261145693 and 22106028)the Ministry of Science and Technology of the People’s Republic of China(MOST)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-19-020A1)the Hundred Talents Program of the Chinese Academy of Sciences,and China Postdoctoral Science Foundation(No.2023M730216).
文摘Arsenic and cadmium contamination frequently coexist in the real environment.However it remains a challenge for their simultaneous removal due to their distinct physicochemica properties at low cost.To this end,a cost-effective magnetic biochar adsorbent (ITBNa800was prepared using biomass waste and iron tailings slag.This composite adsorbent exhibits excellent performance in the simultaneous removal of aqueous As(Ⅴ) and Cd(Ⅱ) even at high concentrations with removal efficiencies of up to 99.98%and 96.04%,respectively.Electro static action,precipitation,and complexation were adsorption mechanisms.As(Ⅴ) and Cd(Ⅱ were synergistic and competitive adsorption.As(Ⅴ) removal was mainly due to physical and chemical adsorption,and 42.40%-58.59%of As(Ⅴ) had been converted to As(Ⅲ ).Cd(Ⅱ) re moval was mainly due to chemical adsorption.Iron oxide and aluminum oxide in ITBNa800were the keys to As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) adsorption.DFT calculations revealed iron oxide complex As(Ⅴ),As(Ⅲ ),and Cd(Ⅱ) molecular clusters through bidentate binuclear,bidentate binuclear,and monodentate binuclear pathways,respectively.Aluminum oxide complex Cd(Ⅱ) molecular cluster through a bidentate mononuclear pathway.We hope the ITBNa800adsorbent and its involved mechanism could offer inspiration in the simultaneous treat ment of As and Cd pollution.
基金supported by the Key R&D Program of Zhejiang Province(Nos.2023C01166 and 2024SJCZX0046)the Zhejiang Provincial Natural Science Foundation of China(Nos.LDT23E05013E05 and LD24E050009)the Natural Science Foundation of Ningbo(No.2021J150),China.
文摘Accuracy allocation is crucial in the accuracy design of machining tools.Current accuracy allocation methods primarily focus on positional deviation,with little consideration for tool direction deviation.To address this issue,we propose a geometric error cost sensitivity-based accuracy allocation method for five-axis machine tools.A geometric error model consisting of 4l error components is constructed based on homogeneous transformation matrices.Volumetric points with positional and tool direction deviations are randomly sampled to evaluate the accuracy of the machine tool.The sensitivity of each error component at these sampling points is analyzed using the Sobol method.To balance the needs of geometric precision and manufacturing cost,a geometric error cost sensitivity function is developed to estimate the required cost.By allocating error components affecting tool direction deviation first and the remaining components second,this allocation scheme ensures that both deviations meet the requirements.We also perform numerical simulation of a BC-type(B-axis and C-axis type)five-axis machine tool to validate the method.The results show that the new allocation scheme reduces the total geometric error cost by 27.8%compared to a uniform allocation scheme,and yields the same positional and tool direction machining accuracies.
基金Project supported by the National Key Research and Development Program of China(2021YFB3500600,2021YFB3500605)Natural Science Foundation of Jiangsu Province(BK20220365)+5 种基金Key R&D Program of Jiangsu Province(BE2022142)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB610002)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_1419)Science and Technology Plan of Yangzhou(YZ2022030,YZ2023020)the State Key Laboratory of Clean and Efficient Coal-fired Power Generation and Pollution Control(D2022FK098)。
文摘The integration of surface filtration and catalytic decomposition functions in catalytic bags enables the synergistic removal of multiple pollutants(such as dust,nitrogen oxide,acid gases,and dioxins)in a single reactor,thus effectively reducing the cost and operational difficulties associated with flue gas treatment.In this study,Mn-Ce-Sm-Sn(MCSS)catalysts were prepared and loaded onto hightemperature resistant polyimide(P84)filter through ultrasonic impregnation to create composite catalytic filter.The results demonstrate that the NO conversion rates of the composite catalytic filter consistently achieve above 95%within the temperature range of 160-260℃,with a chlorobenzene T_(90)value of 230℃.The ultrasonic impregnation method effectively loaded the catalyst onto the filter,ensuring high dispersion both on the surface and inside the filter.This increased exposure of catalyst active sites enhances the catalytic activity of the composite catalytic filter.Additionally,increasing the catalyst loading leads to a gradual decrease in permeability,an increase in pressure drops and the long residence time of the flue gas,thereby improving catalytic activity.Compared to ordinary impregnation methods,ultrasonic impregnation improves the bonding strength between the catalyst and filter,as well as the permeability of the composite catalytic filter under the same loading conditions.Overall,this study presents a novel approach to prepare composite catalytic filter for the simultaneous removal of NO and chlorobenzene at low temperatures.
基金supported in part by the National Natural Science Foundation of China(No.51677030).
文摘The complex working environment of distribution networks tends to cause impermanent single-phase-to-ground(SPG)fault,and high-temperature ground fault arc is prone to endanger lives and power equipment,resulting in large-scale power outages and fire accidents.Thus,fault arc should be extinguished in time.Meanwhile,stable operation conditions of distribution networks and reliable load power supply should be guaranteed to provide high-quality customer service.This paper proposes an active mitigation strategy for SPG fault,and provide active and reactive power compensation at the same time by utilizing an improved flexible power electronic equipment(FPEE)with dc-link sources.These controls are decoupled from each other,so utilization of FPEE is maximized as much as possible.When a SPG fault occurs in distribution networks,FPEE can output,simultaneously,active power,reactive power,and SPG fault compensation current by controlling output current on the d,q,0 coordinate system,respectively.During normal operation of distribution networks,the FPEE can be used as a virtual synchronous generator to compensate load power and its fluctuation.The proposed simultaneous multi-function can also be applied in other cases.Simulation cases are implemented to verify principles and practicability.
文摘A temperature and acoustic impedance simultaneous sensor based on forward stimulated Brillouin scattering(FSBS)in highly nonlinear fiber(HNLF)with high sensitivity and high accuracy is proposed and demonstrated in this paper.High-order acoustic modes(HOAMs)are used to achieve individual or simultaneous measurement of the two parameters.Transverse acoustic waves(TAWs)involved in the FSBS process can efficiently sense the mechanical or environmental changes outside the fiber cladding,which will be reflected in a linear shift of the acoustic resonance frequency.By analyzing the frequencies of specific scattering peaks,the temperature and acoustic impedance outside the fiber cladding can be obtained simultaneously.The highest measured temperature and acoustic impedance sensitivities are 184.93 k Hz/℃and444.56 k Hz/MRayl,and the measurement accuracies are 0.09℃and 0.009 MRayl,respectively,which are both at desirable levels.We believe this work can provide potential application solutions for sensing fields involving temperature or acoustic impedance measurements.
文摘The accuracy of thermal analysis measurements is critical to analyze material properties correctly,making the improvement of measurement precision and proper uncertainty analysis of test results absolutely essential.As a primary thermal analysis instrument,the simultaneous thermal analyzer(STA)has unique advantages,which combines the functionalities of thermogravimetric(TG)analyzersand differential scanning calorimeters(DSC).However,the absence of standard quality control procedures has resulted in poor measurement reproducibility,low accuracy,and inadequate traceability of analytical results.This study utilized a multi-point temperature calibration method based on national certified reference materials to reduce instrument temperature indication errors.On this basis,we innovatively established a comprehensive quality control system encompassing laboratory environmental control,standard method selection,instrument performance verification,reference material traceability,and uncertainty analysis,thereby achieving standardized operational procedures for thermal analysis measurement.Taking the"determination of initial melting temperature of unknown substances"as a representative case study,a component resolution model for thermal analysis test uncertainty was developed.Through systematic analysis of both the reference material-introduced component and measurement repeatability component,complete traceability of test results was achieved.This approach ensures data validity and enhances the accuracy of test results.This provides crucial technical support and practical reference for the standardization of thermal analysis measurement procedure and assessment of result reliability.
文摘Correction to:Nuclear Science and Techniques(2024)36:8 https://doi.org/10.1007/s41365-024-01570-7 In this article the affiliation details for Author Jian Shan were incorrectly given as‘College of Physics and Electronic Engi-neering,Hengyang Normal University,Hengyang 421008,China’but should have been‘School of Nuclear Science and Technology,University of South China,Hengyang 421001,China’.The original article has been corrected.
基金Supported by National Natural Science Foundation of China(Grant Nos.52075076,U1908231)National Key R&D Program of China(Grant No.2019YFA0705304)。
文摘A sudden increase in the radial depth(SIRD)is a distinctive phenomenon in plunge milling.It is typically characterized by a sharp increase in cutting force at the end of the axial feed of the tool,accompanied by harsh machine vibration sounds,which can negatively impact the reliability of plunge milling.This paper proposes an optimization method to eliminate SIRD in five-axis plunge milling.Initially,a five-axis plunge milling experiment and an analysis of the spatial position relationship between the plunge tools and the workpiece revealed that the cause of SIRD is unreasonable tool path planning.Subsequently,using the cutter position and cutter axis vector as variables,an SIRD discrimination model was developed for adjacent cutter positions and extended to multiple cutter positions.Optimizing the plunge milling tool path is considered a multivariate optimization problem that involves determining the cutter point and cutter axis vector.The SIRD discrimination model was used as a constraint function to aid in solving for the variables.The simulation and experimental results indicate that with the remaining volume of material as the optimization target,the optimized plunge milling tool path results in a residual material volume that is less than 60%of the gradually decreasing plunge depth.This optimization decreases the subsequent semi-finishing time of the workpiece and enhances machining efficiency.Additionally,it does not rely on operator experience and facilitates efficient automated optimization of the tool path to exclude SIRD.
基金supported by the National Natural Science Foundation of China(No.22278352)National Key Research and Development Program of China(No.2021YFC3001100)。
文摘Fibers with deformation-triggered responses are essential for smart textiles and wearable electronics.Here,smart core-shell elastomer fibers with a conductive core and a liquid crystal elastomer shell showing simultaneous resistance and color responses are designed and prepared.The conductive core is consisted of interconnected liquid metal nanodroplets dispersed in a polymer matrix and the elastomer shell is made of cholesteric liquid crystals.When stretched,the fiber resistance increases as the interconnected pathways of liquid metal nanodroplets along the fiber axis become narrower,and the selective reflection color from the fiber surface blueshifts since the cholesteric pitch decreases.The smart elastomer fibers could be woven into smart textiles and respond to various mechanical deformations,including stretching,bending,compression and twisting.The average resistance change is 51%under 100%strain and its variation is smaller than 4%over 500 cycles,showing remarkable fatigue resistance.The simultaneous resistance and color responses to mechanical deformations make the fibers attractive for broad applications,such as flexible electronics.
文摘The“First Multidisciplinary Forum on COVID-19,”as one of the pivotal medical forums organized by China during the initial outbreak of the pandemic,garnered significant attention from numerous countries worldwide.Ensuring the seamless execution of the forum’s translation necessitated exceptionally high standards for simultaneous interpreters.This paper,through the lens of the Translation as Adaptation and Selection theory within Eco-Translatology,conducts an analytical study of the live simultaneous interpretation at the First Multidisciplinary Forum on COVID-19.It examines the interpreters’adaptations and selections across multiple dimensions-namely,linguistic,cultural,and communicative-with the aim of elucidating the guiding role and recommendations that Eco-Translatology can offer to simultaneous interpretation.Furthermore,it seeks to provide insights that may enhance the quality of interpreters’oral translations.
基金Supported by the National Natural Science Foundation of China,No.82360111Xinjiang Science and Technology Department-Leading Talents in Technological Innovation-High-Level Leading Talents,No.2022TSYCLJ0034+1 种基金State Key Laboratory for The Cause and Control of High Incidence in Central Asia Jointly Constructed by The Ministry and The Province,No.SKL-HIDCA-2023-2 and No.SKLHIDCA-2024-22Xinjiang Uygur Autonomous Region Graduate Innovation Program,No.XJ2024G153.
文摘BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.
基金supported by the National Key Research and Development Program of China(No.2021YFC3201505-02)Shenzhen Science and Technology Plan Collaborative Innovation Project-Undertake Major National Science and Technology Projects of China(No.CJGJZD2020061710260200).
文摘Heterotrophic denitrification based on polylactic acid(PLAHD)can remove nitrate effectively,but it is expensive and can't remove phosphate.Autotrophic denitrification based on iron sulfide(ISAD)can simultaneously remove nitrate and phosphate cost-effectively,but its nitrate rate is slow.So,iron sulfide mineral/polylactic acid mixotrophic biofilter(ISPLAB)was constructed to combine advantages of ISAD and PLAHD.ISPLAB achieved nitrogen and phosphorus removal rates of 98.04%and 94.12%,respectively,at a hydraulic retention time(HRT)of 24 h.The study also revealed that controlling molecular weight(MW)of PLA improved the release of soluble organic matter;adding iron sulfide enhanced the hydrolysis of PLA and precipitated PO_(4)^(3-) of Fe^(2+)/Fe^(3+),thereby facilitated simultaneous nitrogen and phosphorus removal.Microbial community analysis resulted that denitrifying bacterias(Phaeodactylibacter and Methylotenera),sulfur-reducing bacterias(Hyphomicrobium),sulfur-oxidizing bacteria(Denitratisoma),iron-reducing bacteria(Romboutsia)and hydrolyzed bacterias(norank_f_norank_o_1-20 and norank_f_Caldilineaceae)coexisted in the ISPLAB system.Organics and iron sulfide drived the denitrification process in ISPLAB.
基金supported by the National Natural Science Foundation of China(Nos.21874060 and 22174058,U21A20282)the Science and Technology program of Gansu Province(No.22JR5RA476)。
文摘DNA repair enzymes are important in the repair of DNA lesions for maintaining the genome stability,and their abnormal expression induced various human cancers.Simultaneous detection of these DNA enzymes could provide convincing evidence based on the comparison of the activity of multiple enzymes than on that of single enzyme.Although fluorescence approach has been applied for the simultaneous detection both of DNA repair enzymes,the spectral overlap and multiwavelength excitation severely restrict the number of available fluorophores.Thus,it is difficult to simultaneously detect three enzymes in a single analysis by fluorescence detection.Herein,we developed a method for the simultaneous determination of three DNA repair enzymes including human flap DNA endonuclease 1(FEN1),human alkyladenine DNA glycosylase(hAAG)and uracil DNA glycosylase(UDG)based on the combination of template-free amplification system with capillary electrophoresis-laser induced fluorescence(CE-LIF)detection.The amplification system was adopted to transfer and amplify the enzymatic products into different length DNA fragments which could be separated effectively by CE-LIF without the complicated modification of the capillary inner wall or labeling different tails on signal probes for separation.The method demonstrated a detection limit of 0.07 U/mL(0.08-160 U/mL)for FEN1,2.40 U/mL(2.5-250U/mL)for hAAG and 2.1×10^(-4)U/mL(0.0004-2.5 U/mL)for UDG,the relative standard deviations(RSDs)of peak time and peak area for different analytes were as follows:2.50%-4,37%and 3.24%-7.18%(inter-day);1.37%-2.71%and 1.43%-3.02%(intra-day),4.28%-6.08%and 4.16%-7.57%(column to column),respectively.And it can identify the inhibitor-like drugs,evaluate enzymatic kinetics and achieve the detection of three enzymes in cell extracts,providing a simple and powerful platform for simultaneous detection of more DNA repair enzymes.
基金supported by the National Natural Science Foundation of China(42374134,42304125,U20B6005)the Science and Technology Commission of Shanghai Municipality(23JC1400502)the Fundamental Research Funds for the Central Universities.
文摘Blended acquisition offers efficiency improvements over conventional seismic data acquisition, at the cost of introducing blending noise effects. Besides, seismic data often suffers from irregularly missing shots caused by artificial or natural effects during blended acquisition. Therefore, blending noise attenuation and missing shots reconstruction are essential for providing high-quality seismic data for further seismic processing and interpretation. The iterative shrinkage thresholding algorithm can help obtain deblended data based on sparsity assumptions of complete unblended data, and it characterizes seismic data linearly. Supervised learning algorithms can effectively capture the nonlinear relationship between incomplete pseudo-deblended data and complete unblended data. However, the dependence on complete unblended labels limits their practicality in field applications. Consequently, a self-supervised algorithm is presented for simultaneous deblending and interpolation of incomplete blended data, which minimizes the difference between simulated and observed incomplete pseudo-deblended data. The used blind-trace U-Net (BTU-Net) prevents identity mapping during complete unblended data estimation. Furthermore, a multistep process with blending noise simulation-subtraction and missing traces reconstruction-insertion is used in each step to improve the deblending and interpolation performance. Experiments with synthetic and field incomplete blended data demonstrate the effectiveness of the multistep self-supervised BTU-Net algorithm.
文摘This paper addresses the Multi-Vehicle Routing Problem with Time Windows and Simultaneous Pickup and Delivery(MVRPTWSPD),aiming to optimize logistics distribution routes and minimize total costs.A vehicle routing optimization model is developed based on the operational requirements of the KS Logistics Center,focusing on minimizing vehicle dispatch,loading and unloading,operating,and time window penalty costs.The model incorporates constraints such as vehicle capacity,time windows,and travel distance,and is solved using a genetic algorithm to ensure optimal route planning.Through MATLAB simulations,34 customer points are analyzed,demonstrating that the simultaneous pickup and delivery model reduces total costs by 30.13%,increases vehicle loading rates by 20.04%,and decreases travel distance compared to delivery-only or pickup-only models.The results demonstrate the significant advantages of the simultaneous pickup and delivery mode in reducing logistics costs and improving vehicle utilization,offering valuable insights for enhancing the operational efficiency of the KS Logistics Center.
文摘BACKGROUND Detailed data on the relation of post-operative complications with clinical outcomes after simultaneous pancreas-kidney(SPK)transplantation is lacking.AIM To compare Clavien-Dindo classification(CDC)and comprehensive complication index(CCI)in predicting outcomes after SPK.METHODS Data for patients undergoing SPK between 1999-2019 were analyzed.Information on recipients’baseline characteristics,peri-operative management and postoperative complications were collated.Length of hospital stay(LOS)was the primary study outcome,and the associations with CDC and CCI were evaluated using Spearman’s(ρ)correlation coefficients.RESULTS In the study period,data were available for 128 patients(female n=44,34.4%).Sixty-nine patients had at least one complication with the highest CDC grade of I,II,III,and IV in 8(6.3%),22(17.2%),32(25%),and 7(5.5%)patients,respectively. The mean LOS was 21.4 ± 17.7 days. Both classification systems were correlated with LOS, yet CCI was stronger(Spearman’s ρ: 0.694 vs 0.602, P < 0.001). Female patients (P = 0.019) and patients with pre-transplant cardiovascularevents (P = 0.02) had longer LOS. After adjusted multivariable analysis, the link between LOS and both theCDC and CCI remained relevant. CCI had a superior fit compared to CDC (r2 = 0.729 vs r2 = 0.481), with every 10CCI points being associated with a 5.27 day (P < 0.001) increased LOS.CONCLUSIONThis study showed that the CCI was better linked with LOS compared to CDC and might represent a useful scoreto evaluate the overall burden of postoperative complications in patients undergoing SPK.
