As the speed of optical access networks soars with ever increasing multiple services, the service-supporting ability of optical access networks suffers greatly from the shortage of service awareness. Aiming to solve t...As the speed of optical access networks soars with ever increasing multiple services, the service-supporting ability of optical access networks suffers greatly from the shortage of service awareness. Aiming to solve this problem, a hierarchy Bayesian model based services awareness mechanism is proposed for high-speed optical access networks. This approach builds a so-called hierarchy Bayesian model, according to the structure of typical optical access networks. Moreover, the proposed scheme is able to conduct simple services awareness operation in each optical network unit(ONU) and to perform complex services awareness from the whole view of system in optical line terminal(OLT). Simulation results show that the proposed scheme is able to achieve better quality of services(Qo S), in terms of packet loss rate and time delay.展开更多
目的:比较国内外Agent行为建模与仿真研究热点与趋势,为我国研究者更有效地应用Agent行为建模与仿真提供参考依据。方法:运用CiteSpace5.7R5软件对中国知网和Web of Science核心合集数据库2011年1月1日至2021年3月31日中有关Agent行为...目的:比较国内外Agent行为建模与仿真研究热点与趋势,为我国研究者更有效地应用Agent行为建模与仿真提供参考依据。方法:运用CiteSpace5.7R5软件对中国知网和Web of Science核心合集数据库2011年1月1日至2021年3月31日中有关Agent行为建模与仿真研究的文献进行图谱量化分析。结果:共检索到有效中文文献864篇、英文文献2323篇,国内发文量整体呈下降趋势,国外发文量整体呈上升趋势,发文量高的国家集中在发达国家,国外研究前沿已经延伸到物理学、金融学、哲学、生物学、物流学、人工智能等方面。国内研究热点主要集中在社会学、物理学、网络模型等方面。结论:Agent行为建模与仿真研究的应用范围较广泛,与国际相比国内Agent行为建模与仿真研究还存在一定的差距,研究深度和广度有待进一步拓展,国内应参考国际Agent行为建模与仿真研究的热点及前沿,探索适合我国特色的Agent行为建模与仿真系统体系,以促进我国Agent行为建模与仿真的发展。展开更多
Pregnant women are often complicated with diseases that require treatment with medication.Most drugs administered to pregnant women are off-label without the necessary dose,efficacy,and safety information.Knowledge co...Pregnant women are often complicated with diseases that require treatment with medication.Most drugs administered to pregnant women are off-label without the necessary dose,efficacy,and safety information.Knowledge concerning drug transfer across the placental barrier is essential for understanding fetal drug exposure and hence drug safety and efficacy to the fetus.Transporters expressed in the placenta,including adenosine triphosphate(ATP)-binding cassette efflux transporters and solute carrier uptake transporters,play important roles in determining drug transfer across the placental barrier,leading to fetal exposure to the drugs.In this review,we provide an update on placental drug transport,including in vitro cell/tissue,ex vivo human placenta perfusion,and in vivo animal studies that can be used to determine the expression and function of drug transporters in the placenta as well as placental drug transfer and fetal drug exposure.We also describe how the knowledge of placental drug transfer through passive diffusion or active transport can be combined with physiologically based pharmacokinetic modeling and simulation to predict systemic fetal drug exposure.Finally,we highlight knowledge gaps in studying placental drug transport and predicting fetal drug exposure and discuss future research directions to fill these gaps.展开更多
基金supported by the Science and Technology Project of State Grid Corporation of China:"Research on the Power-Grid Services Oriented"IP+Optics"Coordination Choreography Technology"
文摘As the speed of optical access networks soars with ever increasing multiple services, the service-supporting ability of optical access networks suffers greatly from the shortage of service awareness. Aiming to solve this problem, a hierarchy Bayesian model based services awareness mechanism is proposed for high-speed optical access networks. This approach builds a so-called hierarchy Bayesian model, according to the structure of typical optical access networks. Moreover, the proposed scheme is able to conduct simple services awareness operation in each optical network unit(ONU) and to perform complex services awareness from the whole view of system in optical line terminal(OLT). Simulation results show that the proposed scheme is able to achieve better quality of services(Qo S), in terms of packet loss rate and time delay.
文摘目的:比较国内外Agent行为建模与仿真研究热点与趋势,为我国研究者更有效地应用Agent行为建模与仿真提供参考依据。方法:运用CiteSpace5.7R5软件对中国知网和Web of Science核心合集数据库2011年1月1日至2021年3月31日中有关Agent行为建模与仿真研究的文献进行图谱量化分析。结果:共检索到有效中文文献864篇、英文文献2323篇,国内发文量整体呈下降趋势,国外发文量整体呈上升趋势,发文量高的国家集中在发达国家,国外研究前沿已经延伸到物理学、金融学、哲学、生物学、物流学、人工智能等方面。国内研究热点主要集中在社会学、物理学、网络模型等方面。结论:Agent行为建模与仿真研究的应用范围较广泛,与国际相比国内Agent行为建模与仿真研究还存在一定的差距,研究深度和广度有待进一步拓展,国内应参考国际Agent行为建模与仿真研究的热点及前沿,探索适合我国特色的Agent行为建模与仿真系统体系,以促进我国Agent行为建模与仿真的发展。
基金supported by the National Institute on Drug Abuse(Grant P01DA032507)the Eunice Kennedy Shriver National Institute of Child Health and Human Development(Grant R01HD102786)。
文摘Pregnant women are often complicated with diseases that require treatment with medication.Most drugs administered to pregnant women are off-label without the necessary dose,efficacy,and safety information.Knowledge concerning drug transfer across the placental barrier is essential for understanding fetal drug exposure and hence drug safety and efficacy to the fetus.Transporters expressed in the placenta,including adenosine triphosphate(ATP)-binding cassette efflux transporters and solute carrier uptake transporters,play important roles in determining drug transfer across the placental barrier,leading to fetal exposure to the drugs.In this review,we provide an update on placental drug transport,including in vitro cell/tissue,ex vivo human placenta perfusion,and in vivo animal studies that can be used to determine the expression and function of drug transporters in the placenta as well as placental drug transfer and fetal drug exposure.We also describe how the knowledge of placental drug transfer through passive diffusion or active transport can be combined with physiologically based pharmacokinetic modeling and simulation to predict systemic fetal drug exposure.Finally,we highlight knowledge gaps in studying placental drug transport and predicting fetal drug exposure and discuss future research directions to fill these gaps.
