Vulnerability assessment is a systematic process to identify security gaps in the design and evaluation of physical protection systems.Adversarial path planning is a widely used method for identifying potential vulner...Vulnerability assessment is a systematic process to identify security gaps in the design and evaluation of physical protection systems.Adversarial path planning is a widely used method for identifying potential vulnerabilities and threats to the security and resilience of critical infrastructures.However,achieving efficient path optimization in complex large-scale three-dimensional(3D)scenes remains a significant challenge for vulnerability assessment.This paper introduces a novel A^(*)-algorithmic framework for 3D security modeling and vulnerability assessment.Within this framework,the 3D facility models were first developed in 3ds Max and then incorporated into Unity for A^(*)heuristic pathfinding.The A^(*)-heuristic pathfinding algorithm was implemented with a geometric probability model to refine the detection and distance fields and achieve a rational approximation of the cost to reach the goal.An admissible heuristic is ensured by incorporating the minimum probability of detection(P_(D)^(min))and diagonal distance to estimate the heuristic function.The 3D A^(*)heuristic search was demonstrated using a hypothetical laboratory facility,where a comparison was also carried out between the A^(*)and Dijkstra algorithms for optimal path identification.Comparative results indicate that the proposed A^(*)-heuristic algorithm effectively identifies the most vulnerable adversarial pathfinding with high efficiency.Finally,the paper discusses hidden phenomena and open issues in efficient 3D pathfinding for security applications.展开更多
AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic （HD） systems. The influences of polarization charge and quantum effects are considered i...AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic （HD） systems. The influences of polarization charge and quantum effects are considered in this model. Then the two-dimensional conduction band and electron distribution, electron temperature characteristics, Id versus Vd and Id versus Vg, transfer characteristics and transconductance curves are obtained. Corresponding analysis and discussion based on the simulation results are subsequently given.展开更多
Aiming at the issues of poor scalability,single training modes,and missing platform foundation in current parachute training simulation systems,a method for a parachute training simulation system supporting the"1...Aiming at the issues of poor scalability,single training modes,and missing platform foundation in current parachute training simulation systems,a method for a parachute training simulation system supporting the"1+N+N"mode is proposed by building a flexible functional structure design based on four domains and two systems architecture,which can adapt to multiple working modes such as"1+N"and"1+N(*)".This method can effectively save the cost and time of upgrading and expanding system capacity,greatly increasing the lifespan and availability of the system.展开更多
Terrestrial ecosystems are vital for maintaining equilibrium in the global carbon cycle.Land use and land cover change(LUCC),which is influenced mainly by urbanization and ecological policies,impacts terrestrial ecosy...Terrestrial ecosystems are vital for maintaining equilibrium in the global carbon cycle.Land use and land cover change(LUCC),which is influenced mainly by urbanization and ecological policies,impacts terrestrial ecosystem carbon storage significantly.In this study,spatiotemporal carbon storage changes in the urban belt along the Yellow River in the Ningxia Hui Autonomous Region,China,were estimated through a model that integrated patch-generating land use simulation(PLUS)and integrated valuation of ecosystem services and tradeoffs(InVEST)models from 1993 to 2033.The results revealed that:(1)from 1993 to 2023,the expansion of built-up land and cropland was derived mainly from unused land and grassland,whereas water body and woodland remained relatively stable.Projections to 2033 have indicated that LUCC will continue and be concentrated primarily in the Ningxia Plain;(2)carbon storage increased by a net 5.01×10^(6) Mg C from 1993 to 2023;(3)the spatial distribution of carbon storage revealed that high-value areas were predominantly located in the Helan Mountains and the Ningxia Plain,whereas low-value areas were found in the Tengger Desert;(4)scenario projections indicated that by 2033,the ecological protection scenario(EPS)would achieve a 0.18×10^(6) Mg C increase by reducing the conversion of woodland to cropland and grassland to built-up land,while increasing the conversion of unused land to grassland.In contrast,the natural development scenario(NDS),cropland protection scenario(CPS),and urban development scenario(UDS)decreased carbon storage by 0.60×10^(6),0.21×10^(6),and 0.42×10^(6) Mg C,respectively;and(5)spatial autocorrelation analysis revealed that high–high carbon storage clusters formed belt-like patterns along the Ningxia Plain and the Helan Mountains,whereas the low–low carbon storage clusters were concentrated in northern Zhongwei City,western Qingtongxia City,western Dawukou District,and the urbanized areas within the central Ningxia Plain.Overall,the study results revealed the close coupling relationship between LUCC and carbon storage functions.Furthermore,the study establishes a framework for carbon management that balances ecological protection with coordinated urban development for the urban belt as well as for similar arid and semi-arid areas.On the basis of these findings,this study provides decision-makers with guidance to optimize ecosystem carbon storage via land use,which plays a key role in developing future land use policies and achieving the"dual carbon"goals.展开更多
Land use in arid and semi-arid regions has a substantial effect on climate,environment,and biodiversity,thereby projecting the spatiotemporal changes in land use and the subsequent effects.This study employed the loca...Land use in arid and semi-arid regions has a substantial effect on climate,environment,and biodiversity,thereby projecting the spatiotemporal changes in land use and the subsequent effects.This study employed the locally calibrated Future Land Use Simulation(FLUS)model,which coupled system dynamics with cellular automata and integrated an artificial neural network algorithm and a roulette wheel selection mechanism.We projected future land use(2020–2100)dynamics of Lanzhou,a typical river valley city in Northwest China,under three different Shared Socioeconomic Pathway(SSP)scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5).The simulation results were validated and subsequently reclassified using the International Geosphere Biosphere Programme(IGBP)system to produce a dataset suitable for driving climatic and environmental models.Under the SSP1-2.6 scenario,urban and built-up land expanded consistently,whereas irrigated cropland and pasture as well as grassland contracted continuously.Conversely,the SSP5-8.5 scenario was characterized by a contraction of urban and built-up land,and relative stability of irrigated cropland and pasture as well as grassland.The SSP2-4.5 scenario presented a more complex trade-off,where urban and built-up land and grassland increased first and then decreased,whereas irrigated cropland and pasture followed an opposite trajectory.A significant inverse relationship between urban and built-up land and irrigated cropland and pasture was observed under all scenarios,underscoring the fundamental spatial competition that prevailed in this land-constrained valley city.Furthermore,the negative correlation of grassland with urban and built-up land,coupled with the positive correlation of grassland with irrigated cropland and pasture under both the SSP1-2.6 and SSP5-8.5 scenarios,indicated an evolution from broad confrontation to intricate internal trade-offs within the urban–agricultural–ecological system.This study underscored the critical influence of regional topographic and hydrological constraints on land-use evolution in arid regions,providing guidance for water resource management and ecosystem protection in Lanzhou,with applications for sustainable land-use planning in other arid and semi-arid river valley cities.展开更多
Coordinating urban development with the protection of water resources is a serious global challenge faced by countries worldwide.This study constructed the coupled Water Ecological Security Pattern-Future Land Use Sim...Coordinating urban development with the protection of water resources is a serious global challenge faced by countries worldwide.This study constructed the coupled Water Ecological Security Pattern-Future Land Use Simulation(WESP-FLUS) model by integrating methods for identifying water–ecological sensitive areas and simulating land use type changes.Taking the Lanzhou-Baiyin metropolitan area in arid region of northwestern China as a case study,this research simulated land use patterns in 2030 under four development scenarios(natural development,urban economic optimization,ecological conservation priority,and urban-water coordinated development scenarios).The results identified 109.81 km^(2) of water–ecological source areas and 43 water–ecological corridors with a total length of 1255.4 km.Predicted land use patterns for 2030 displayed diverse trends,constrained by water–ecological sensitive areas across different scenarios,with urban built-up land mainly expanding radially around the central urban axis.The urban-water coordinated development scenario was the optimal solution that meets both urban development needs and water–ecological protection objectives.The urban built-up land could reach 546.68 km2 in 2030,representing a 91.39 km^(2) increase compared to 2020.This study aims to improve spatial planning methods under the “determining cities by water” concept,scientifically supporting territorial spatial planning and providing theoretical support for the coupling of urban development and natural environment in water-scarce arid regions.展开更多
Sand dust belts span approximately one-fifth of the global land surface.In these regions,dust tends to settle on vegetation surfaces,altering the observed reflectance and affecting remote sensing detections.To enhance...Sand dust belts span approximately one-fifth of the global land surface.In these regions,dust tends to settle on vegetation surfaces,altering the observed reflectance and affecting remote sensing detections.To enhance the accuracy of maize growth monitoring in dust-affected regions,this study aims to quantify the effect of sand dust retention on maize during the tasseling stage in the Kashgar Prefecture,Xinjiang Uygur Autonomous Region,China,by analyzing changes in canopy reflectance and vegetation indices.First,field sampling was conducted to measure the key canopy structure parameters and dust retention levels of maize,and laboratory spectral measurements were performed on leaf spectral properties under gradient dust retention.The measured data were then used to drive the LargE-Scale remote sensing data and image Simulation framework(LESS)model for simulating realistic maize canopy spectra across different dust levels,with validation against Sentinel-2 imagery.Second,on the basis of the simulated and satellite-derived spectra,the dust resistance of 36 common vegetation indices was systematically evaluated,and new robust dust-resistant indices were developed.The results showed that compared with dust-free maize,the canopy reflectance of dust-retained maize followed an increase–decrease–increase pattern,with critical turning points at 735 and 1325 nm.The maximum reflectance difference of–0.11755(change rate:29.002%)occurred within the 735–1325 nm range at 24 g/m^(2)dust retention,and the minimum reflectance difference of 0.04285(change rate:148.950%)was observed in the 350–735 nm range under the same dust retention level.Among the 36 vegetation indices,only the global environment monitoring index(GEMI)and the ratio of transformed chlorophyll absorption in reflectance index to optimized soil-adjusted vegetation index(TCARI/OSAVI)exhibited dust resistance,with GEMI being effective below 6 g/m^(2)and TCARI/OSAVI remaining stable across all levels(average ratio:0.970).The newly developed indices in this study,(RE3–RE2)/(NIR–RE2),(RE3–RE2)/(RE4–RE2),and(NIR–RE2)/(RE4–RE2),retained values within the predefined dust-resistant range over the full dust retention levels of 0–24 g/m^(2),thus showing a more stable dust resistance compared with the commonly used 36 vegetation indices.Specially,(RE3–RE2)/(RE4–RE2)performed the most robustly in Sentinel-2 imagery,that is,58.020%of pixels were within the dust-resistant range,and an average ratio of 0.937 was obtained for the original-spectra index.This study provides a scientific basis for crop monitoring and management in dust-affected regions.展开更多
The epidermal growth factor receptor（EGFR）—tyrosine kinase inhibitors（TKIs） monotherapies have limited efficacy in the treatment of EGFR mutation-negative non-small cell lung cancers（NSCLCs）. In the present stu...The epidermal growth factor receptor（EGFR）—tyrosine kinase inhibitors（TKIs） monotherapies have limited efficacy in the treatment of EGFR mutation-negative non-small cell lung cancers（NSCLCs）. In the present study, we aimed to investigate the combined effect of erlotinib（ER） and cabozantinib（CAB） on NSCLC cell lines harboring wild-type EGFR and to optimize the dosage regimens using pharmacodynamic（PD） modeling and simulation. Therefore, we examined the combined effect of ER and CAB on cell viability, cloning, apoptosis induction, migration and growth dynamics in H1299 and A549 cells. PD modeling and simulation were also performed to quantitatively describe the H1299 cells growth dynamics and to optimize the dosage regimens as well. Our results showed that CAB effectively enhanced the sensitivity of both cell lines to ER. The PD models fitted the data well, and some important parameters were obtained. The exponential（λ_0） and linear（λ_1） growth rates of H1299 cells were 0.0241 h^（–1） and 360 cells？h^（–1）, respectively. The Emax of ER and CAB was 0.0091 h^（–1） and 0.0085 h^（–1）, and the EC50 was 0.812 μM and 1.16 μM, respectively. The synergistic effect observed in the experiments was further confirmed by the estimated combination index φ（1.37）,（95% confidence interval： 1.24–1.50）, obtained from PD modeling. Furthermore, the dosage regimens were optimized using simulations. In summary, both the experimental and modeling results demonstrated the synergistic interaction between ER and CAB in NSCLCs without EGFR mutations. Sequential combinations of ER and CAB provided an option for the therapy of the NSCLCs with wild-type EGFR, which would provide some references for preclinical study and translational research as well.展开更多
A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water...A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water relations under both drought and waterlogging conditions in two sequential growing seasons from 2000 to 2002, and then the data were used to develop and validate models simulating the responses of winter wheat growth to drought and waterlogging stress. The experiment consisted of four treatments, waterlogging (keep 1 to 2 cm water layer depth above soil surface), control (70%-80% field capacity), light drought (40%-50% field capacity) and severe drought (30%-40% field capacity) with six replicates at five stages in the 2000-2001 growth season. Three soil water content treatments (waterlogging, control and drought) with two replicates were designed in the 2001-2002 growth season. Waterlogging and control treatments are the same as in the 2000-2001 growth season. For the drought treatment, no water was supplied and the soil moisture decreased from field capacity to wilting point. Leaf net photosynthetic rate, transpiration rate, predawn leaf water potential, soil water potential, soil water content and dry matter weight of individual organs were measured. Based on crop-water eco-physiological relations, drought and waterlogging stress factors for winter wheat growth simulation model were put forward. Drought stress factors integrated soil water availability, the sensitivity of different development stages and the difference between physiological processes (such as photosynthesis, transpiration and partitioning). The quantification of waterlogging stress factor considered different crop species, soil water status, waterlogging days and sensitivity at different growth stages. Data sets from the pot experiments revealed favorable performance reliability for the simulation sub-models with the drought and waterlogging stress factors.展开更多
Six paddy soils of Shanghai, China, were studied after 120 days of anaerobicincubation at 25 deg C and 35 deg C. Four models, the effective accumulated temperature model, theone-component first-order exponential model...Six paddy soils of Shanghai, China, were studied after 120 days of anaerobicincubation at 25 deg C and 35 deg C. Four models, the effective accumulated temperature model, theone-component first-order exponential model (the one-pool model), the two-component first-orderexponential model (the two-pool model), and the two-component first-order plus zero-orderexponential model including a constant term (the special model), were fitted to the data of observedmineral-N during incubation using non-linear regression procedures. The two-pool model and thespecial model gave the best fits amongst the four models, and parameters in the special model weremore reasonable than those in the other three. Results showed that the special model gave a betterprediction of nitrogen mineralization under flooded conditions than the other three models.展开更多
Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channe...Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency.展开更多
Crop performance is determined by the combined effects of the genotype of the crop and the environmental conditions of the production system. This study was undertaken to develop a dynamic model for simulating environ...Crop performance is determined by the combined effects of the genotype of the crop and the environmental conditions of the production system. This study was undertaken to develop a dynamic model for simulating environmental （temperature and solar radiation） and N supply effects on fiber fineness, maturity and micronaire. Three different experiments involving genotypes, sowing dates, and N fertilization rates were conducted to support model development and model evaluation. The growth and development duration of fiber fineness, maturity, and micronaire were scaled by using physiological development time of secondary wall synthesis （PDT SWSP ）, which was determined based on the constant ratio of SWSP/ BMP. PTP （product of relative thermal effectiveness （RTE） and photosynthetically active radiation （PAR）, MJ m-2） and subtending leaf N content per unit area （N A , g m-2） and critical subtending leaf N content per unit area （CN A , g m-2） of cotton boll were calculated or simulated to evaluate effects of temperature and radiation, and N supply. Besides, the interactions among temperature, radiation and N supply were also explained by piecewise function. The overall performance of the model was calibrated and validated with independent data sets from three field experiments with two sowing dates, three or five flowering dates and three or four N fertilization rates for three subsequent years （2005, 2007, and 2009） at three ecological locations. The average RMSE and RE for fiber fineness, maturity, and micronaire predictions were 372 m g-1 and 5.0%, 0.11 m g-1 and 11.4%, 0.3 m g-1 and 12.3%, respectively, indicating a good fit between the simulated and observed data. It appears that the model can give a reliable prediction for fiber fineness, maturity and micronaire formation under various growing conditions.展开更多
In this study, a regional air quality model system （RAQMS） was applied to investigate the spatial distributions and seasonal variations of atmospheric aerosols in 2006 over East Asia. Model validations demonstrated ...In this study, a regional air quality model system （RAQMS） was applied to investigate the spatial distributions and seasonal variations of atmospheric aerosols in 2006 over East Asia. Model validations demonstrated that RAQMS was able to reproduce the evolution processes of aerosol components reasonably well. Ground-level PM10 （particles with aerodynamic diameter ≤10 μm） concentrations were highest in spring and lowest in summer and were characterized by three maximum centers： the Taklimakan Desert （-1000 μg m^-3）, the Gobi Desert （-400 μg m^-3）, and the Huabei Plain （- 300 μg m^-3） of China. Vertically, high PM10 concentrations ranging from 100 μg m-3 to 250 μg m-3 occurred from the surface to an altitude of 6000 m at 30°-45°N in spring. In winter, the vertical gradient was so large that most aerosols were restricted in the boundary layer. Both sulfate and ammonium reached their highest concentrations in autumn, while nitrate reached its maximum level in winter. Black carbon and organic carbon aerosol concentrations reached maximums in winter. Soil dust were strongest in spring, whereas sea salt exerted the strongest influence on the coastal regions of eastern China in summer. The estimated burden of anthropogenic aerosols was largest in winter （1621 Gg） and smallest in summer （1040 Gg）. The sulfate burden accounted for -42% of the total anthropogenic aerosol burden. The dust burden was about twice the anthropogenic aerosol burden, implying the potentially important impacts of the natural aerosols on air quality and climate over East Asia.展开更多
OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese pa...OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.展开更多
As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With...As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With the rapid development of advanced high-performance aeroengine,the increasing demand of high-altitude simulation test is driving AGTF to improve its test ability and level of automation and intelligence.The modeling method,simulation tool,and control technology are the key factors to support the improvement of the AGTF control system.The main purpose of this paper is to provide an overview of modeling methods,simulation tools,and control technologies in AGTF control system for future research.First,it reviews the evolution of AGTF in the world,from the early formative stage to integration stage.Then,the mathematical modeling method of AGTF for control application is overviewed.Furthermore,the simulation tools used in the AGTF control system are overviewed from numerical simulation to hardware-in-loop simulation and further to semi-physical simulation.Meanwhile,the control technologies used in the AGTF control system are summarized from single-variable control to multivariable integrated control,and from classical control theory to modern control theory.Finally,recommendations for future research are outlined.Therefore,this review article provides extensive literature information for the modeling,simulation,and control design of AGTF for control application.展开更多
Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatica...Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments.展开更多
Simulation models of heat and water transport have not been rigorously tested for the red soils of southern China. Based on the theory of nonisothermal water-heat coupled transfer, a simulation model, programmed in Vi...Simulation models of heat and water transport have not been rigorously tested for the red soils of southern China. Based on the theory of nonisothermal water-heat coupled transfer, a simulation model, programmed in Visual Basic 6.0, was developed to predict the coupled transfer of water and heat in hilly red soil. A series of soil column experiments for soil water and heat transfer, including soil columns with closed and evaporating top ends, were used to test the simulation model. Results showed that in the closed columns, the temporal and spatial distribution of moisture and heat could be very well predicted by the model, while in the evaporating columns, the simulated soil water contents were somewhat different from the observed ones. In the heat flow equation by Taylor and Lary (1964), the effect of soil water evaporation on the heat flow is not involved, which may be the main reason for the differences between simulated and observed results. The predicted temperatures were not in agreement with the observed one with thermal conductivities calculated by de Vries and Wierenga equations, so that it is suggested that Kh, soil heat conductivity, be multiplied by 8.0 for the first 6.5 h and by 1.2 later on. Sensitivity analysis of soil water and heat coefficients showed that the saturated hydraulic conductivity, KS, and the water diffusivity, D(θ), had great effects on soil water transport; the variation of soil porosity led to the difference of soil thermal properties, and accordingly changed temperature redistribution, which would affect water redistribution.展开更多
Accurate acid placement constitutes a major concern in matrix stimulation because the acid tends to penetrate the zones of least resistance while leaving the low-permeability regions of the formation untreated.Degrada...Accurate acid placement constitutes a major concern in matrix stimulation because the acid tends to penetrate the zones of least resistance while leaving the low-permeability regions of the formation untreated.Degradable materials(fibers and solid particles)have recently shown a good capability as fluid diversion to overcome the issues related to matrix stimulation.Despite the success achieved in the recent acid stimulation jobs stemming from the use of some products that rely on fiber flocculation as the main diverting mechanism,it was observed that the volume of the base fluid and the loading of the particles are not optimized.The current industry lacks a scientific design guideline because the used methodology is based on experience or empirical studies in a particular area with a particular product.It is important then to understand the fundamentals of how acid diversion works in carbonates with different diverting mechanisms and diverters.Mathematical modeling and computer simulations are effective tools to develop this understanding and are efficiently applied to new product development,new applications of existing products or usage optimization.In this work,we develop a numerical model to study fiber dynamics in fluid flow.We employ a discrete element method in which the fibers are represented by multi-rigid-body systems of interconnected spheres.The discrete fiber model is coupled with a fluid flow solver to account for the inherent simultaneous interactions.The focus of the study is on the tendency for fibers to flocculate and bridge when interacting with suspending fluids and encountering restrictions that can be representative of fractures or wormholes in carbonates.The trends of the dynamic fiber behavior under various operating conditions including fiber loading,flow rate and fluid viscosity obtained from the numerical model show consistency with experimental observations.The present numerical investigation reveals that the bridging capability of the fiber–fluid system can be enhanced by increasing the fiber loading,selecting fibers with higher stiffness,reducing the injection flow rate,reducing the suspending fluid viscosity or increasing the attractive cohesive forces among fibers by using sticky fibers.展开更多
In order to better study the dynamic characteristics and the control strategy of parafoil systems,considering the effect of flap deflection as the control mechanism and regarding the parafoil and the payload as a rigi...In order to better study the dynamic characteristics and the control strategy of parafoil systems,considering the effect of flap deflection as the control mechanism and regarding the parafoil and the payload as a rigid body,a six degrees-of-freedom(DOF)dynamic model of a parafoil system including three DOF for translational motion and three DOF for rotational motion,is established according to the K rchhoff motion equation.Since the flexible winged paafoil system flying at low altitude is more susceptibleto winds,the motion characteristics of the parafoil system Wth and Wthout winds are simulated and analyzed.Furthermore,the ardropm test is used to further verify the model.The comparison results show that the simulation trajectory roughly overlaps with the actual flight track.The horzontnl velocity of the simulation model is in good accordance with the airdrop test,with a deviation less than0.5m/s,while its simulated vertical velocity fuctuates slightly under the infuence of the wind,and shows a similar trend to the ardrop test.It is concludedthat the established model can well describe the characteristics of the parafoil system.展开更多
ABSTRACT Rainfall responses to doubled atmospheric carbon dioxide concentration were investigated through the analysis of two pairs of two-dimensional cloud-resolving model sensitivity experiments. One pair of experi...ABSTRACT Rainfall responses to doubled atmospheric carbon dioxide concentration were investigated through the analysis of two pairs of two-dimensional cloud-resolving model sensitivity experiments. One pair of experiments simulated pre-summer heavy rainfall over southern China around the summer solstice, whereas the other pair of experiments simulated tropical rainfall around the winter solstice. The analysis of the time and model domain mean heat budget revealed that the enhanced local atmospheric warming was associated with doubled carbon dioxide through the weakened infrared radiative cooling during the summer solstice. The weakened mean pre-summer rainfall corresponded to the weakened mean infrared radiative cooling. Doubled carbon dioxide increased the mean tropical atmospheric warming via the enhanced mean latent heat in correspondence with the strengthened mean infrared radiative cooling during the winter solstice. The enhanced mean tropical rainfall was associated with the increased mean latent heat.展开更多
基金supported by the fundings from 2024 Young Talents Program for Science and Technology Thinking Tanks(No.XMSB20240711041)2024 Student Research Program on Dynamic Simulation and Force-on-Force Exercise of Nuclear Security in 3D Interactive Environment Using Reinforcement Learning,Natural Science Foundation of Top Talent of SZTU(No.GDRC202407)+2 种基金Shenzhen Science and Technology Program(No.KCXFZ20240903092603005)Shenzhen Science and Technology Program(No.JCYJ20241202124703004)Shenzhen Science and Technology Program(No.KJZD20230923114117032)。
文摘Vulnerability assessment is a systematic process to identify security gaps in the design and evaluation of physical protection systems.Adversarial path planning is a widely used method for identifying potential vulnerabilities and threats to the security and resilience of critical infrastructures.However,achieving efficient path optimization in complex large-scale three-dimensional(3D)scenes remains a significant challenge for vulnerability assessment.This paper introduces a novel A^(*)-algorithmic framework for 3D security modeling and vulnerability assessment.Within this framework,the 3D facility models were first developed in 3ds Max and then incorporated into Unity for A^(*)heuristic pathfinding.The A^(*)-heuristic pathfinding algorithm was implemented with a geometric probability model to refine the detection and distance fields and achieve a rational approximation of the cost to reach the goal.An admissible heuristic is ensured by incorporating the minimum probability of detection(P_(D)^(min))and diagonal distance to estimate the heuristic function.The 3D A^(*)heuristic search was demonstrated using a hypothetical laboratory facility,where a comparison was also carried out between the A^(*)and Dijkstra algorithms for optimal path identification.Comparative results indicate that the proposed A^(*)-heuristic algorithm effectively identifies the most vulnerable adversarial pathfinding with high efficiency.Finally,the paper discusses hidden phenomena and open issues in efficient 3D pathfinding for security applications.
文摘AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic （HD） systems. The influences of polarization charge and quantum effects are considered in this model. Then the two-dimensional conduction band and electron distribution, electron temperature characteristics, Id versus Vd and Id versus Vg, transfer characteristics and transconductance curves are obtained. Corresponding analysis and discussion based on the simulation results are subsequently given.
文摘Aiming at the issues of poor scalability,single training modes,and missing platform foundation in current parachute training simulation systems,a method for a parachute training simulation system supporting the"1+N+N"mode is proposed by building a flexible functional structure design based on four domains and two systems architecture,which can adapt to multiple working modes such as"1+N"and"1+N(*)".This method can effectively save the cost and time of upgrading and expanding system capacity,greatly increasing the lifespan and availability of the system.
基金supported by the National Natural Sciences Foundation of China(42261026)the Open Foundation of Xinjiang Key Laboratory of Water Cycle and Utilization in Arid Zone(XJYS0907-2023-01)the Light of the West Program for Young Scholars,Chinese Academy of Sciences(25JR6KA005).
文摘Terrestrial ecosystems are vital for maintaining equilibrium in the global carbon cycle.Land use and land cover change(LUCC),which is influenced mainly by urbanization and ecological policies,impacts terrestrial ecosystem carbon storage significantly.In this study,spatiotemporal carbon storage changes in the urban belt along the Yellow River in the Ningxia Hui Autonomous Region,China,were estimated through a model that integrated patch-generating land use simulation(PLUS)and integrated valuation of ecosystem services and tradeoffs(InVEST)models from 1993 to 2033.The results revealed that:(1)from 1993 to 2023,the expansion of built-up land and cropland was derived mainly from unused land and grassland,whereas water body and woodland remained relatively stable.Projections to 2033 have indicated that LUCC will continue and be concentrated primarily in the Ningxia Plain;(2)carbon storage increased by a net 5.01×10^(6) Mg C from 1993 to 2023;(3)the spatial distribution of carbon storage revealed that high-value areas were predominantly located in the Helan Mountains and the Ningxia Plain,whereas low-value areas were found in the Tengger Desert;(4)scenario projections indicated that by 2033,the ecological protection scenario(EPS)would achieve a 0.18×10^(6) Mg C increase by reducing the conversion of woodland to cropland and grassland to built-up land,while increasing the conversion of unused land to grassland.In contrast,the natural development scenario(NDS),cropland protection scenario(CPS),and urban development scenario(UDS)decreased carbon storage by 0.60×10^(6),0.21×10^(6),and 0.42×10^(6) Mg C,respectively;and(5)spatial autocorrelation analysis revealed that high–high carbon storage clusters formed belt-like patterns along the Ningxia Plain and the Helan Mountains,whereas the low–low carbon storage clusters were concentrated in northern Zhongwei City,western Qingtongxia City,western Dawukou District,and the urbanized areas within the central Ningxia Plain.Overall,the study results revealed the close coupling relationship between LUCC and carbon storage functions.Furthermore,the study establishes a framework for carbon management that balances ecological protection with coordinated urban development for the urban belt as well as for similar arid and semi-arid areas.On the basis of these findings,this study provides decision-makers with guidance to optimize ecosystem carbon storage via land use,which plays a key role in developing future land use policies and achieving the"dual carbon"goals.
基金supported by the Soft Science Special Project of Gansu Basic Research Plan(25JRZA206)the Longyuan Youth Talent Project of Gansu Province(ZHU Rong)+1 种基金the Innovation Development Special Project of China Meteorological Administration(CXFZ2025J036)the Program of the State Key Laboratory of Cryospheric Science and Frozen Soil Engineering,Chinese Academy of Sciences(CSFSE-KF-2402).
文摘Land use in arid and semi-arid regions has a substantial effect on climate,environment,and biodiversity,thereby projecting the spatiotemporal changes in land use and the subsequent effects.This study employed the locally calibrated Future Land Use Simulation(FLUS)model,which coupled system dynamics with cellular automata and integrated an artificial neural network algorithm and a roulette wheel selection mechanism.We projected future land use(2020–2100)dynamics of Lanzhou,a typical river valley city in Northwest China,under three different Shared Socioeconomic Pathway(SSP)scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5).The simulation results were validated and subsequently reclassified using the International Geosphere Biosphere Programme(IGBP)system to produce a dataset suitable for driving climatic and environmental models.Under the SSP1-2.6 scenario,urban and built-up land expanded consistently,whereas irrigated cropland and pasture as well as grassland contracted continuously.Conversely,the SSP5-8.5 scenario was characterized by a contraction of urban and built-up land,and relative stability of irrigated cropland and pasture as well as grassland.The SSP2-4.5 scenario presented a more complex trade-off,where urban and built-up land and grassland increased first and then decreased,whereas irrigated cropland and pasture followed an opposite trajectory.A significant inverse relationship between urban and built-up land and irrigated cropland and pasture was observed under all scenarios,underscoring the fundamental spatial competition that prevailed in this land-constrained valley city.Furthermore,the negative correlation of grassland with urban and built-up land,coupled with the positive correlation of grassland with irrigated cropland and pasture under both the SSP1-2.6 and SSP5-8.5 scenarios,indicated an evolution from broad confrontation to intricate internal trade-offs within the urban–agricultural–ecological system.This study underscored the critical influence of regional topographic and hydrological constraints on land-use evolution in arid regions,providing guidance for water resource management and ecosystem protection in Lanzhou,with applications for sustainable land-use planning in other arid and semi-arid river valley cities.
基金supported by the National Natural Science Foundation of China (42471230)。
文摘Coordinating urban development with the protection of water resources is a serious global challenge faced by countries worldwide.This study constructed the coupled Water Ecological Security Pattern-Future Land Use Simulation(WESP-FLUS) model by integrating methods for identifying water–ecological sensitive areas and simulating land use type changes.Taking the Lanzhou-Baiyin metropolitan area in arid region of northwestern China as a case study,this research simulated land use patterns in 2030 under four development scenarios(natural development,urban economic optimization,ecological conservation priority,and urban-water coordinated development scenarios).The results identified 109.81 km^(2) of water–ecological source areas and 43 water–ecological corridors with a total length of 1255.4 km.Predicted land use patterns for 2030 displayed diverse trends,constrained by water–ecological sensitive areas across different scenarios,with urban built-up land mainly expanding radially around the central urban axis.The urban-water coordinated development scenario was the optimal solution that meets both urban development needs and water–ecological protection objectives.The urban built-up land could reach 546.68 km2 in 2030,representing a 91.39 km^(2) increase compared to 2020.This study aims to improve spatial planning methods under the “determining cities by water” concept,scientifically supporting territorial spatial planning and providing theoretical support for the coupling of urban development and natural environment in water-scarce arid regions.
基金supported by the Fundamental Research Funds for the Central Universities(N2001020)the National Natural Science Foundation of China(41201359).
文摘Sand dust belts span approximately one-fifth of the global land surface.In these regions,dust tends to settle on vegetation surfaces,altering the observed reflectance and affecting remote sensing detections.To enhance the accuracy of maize growth monitoring in dust-affected regions,this study aims to quantify the effect of sand dust retention on maize during the tasseling stage in the Kashgar Prefecture,Xinjiang Uygur Autonomous Region,China,by analyzing changes in canopy reflectance and vegetation indices.First,field sampling was conducted to measure the key canopy structure parameters and dust retention levels of maize,and laboratory spectral measurements were performed on leaf spectral properties under gradient dust retention.The measured data were then used to drive the LargE-Scale remote sensing data and image Simulation framework(LESS)model for simulating realistic maize canopy spectra across different dust levels,with validation against Sentinel-2 imagery.Second,on the basis of the simulated and satellite-derived spectra,the dust resistance of 36 common vegetation indices was systematically evaluated,and new robust dust-resistant indices were developed.The results showed that compared with dust-free maize,the canopy reflectance of dust-retained maize followed an increase–decrease–increase pattern,with critical turning points at 735 and 1325 nm.The maximum reflectance difference of–0.11755(change rate:29.002%)occurred within the 735–1325 nm range at 24 g/m^(2)dust retention,and the minimum reflectance difference of 0.04285(change rate:148.950%)was observed in the 350–735 nm range under the same dust retention level.Among the 36 vegetation indices,only the global environment monitoring index(GEMI)and the ratio of transformed chlorophyll absorption in reflectance index to optimized soil-adjusted vegetation index(TCARI/OSAVI)exhibited dust resistance,with GEMI being effective below 6 g/m^(2)and TCARI/OSAVI remaining stable across all levels(average ratio:0.970).The newly developed indices in this study,(RE3–RE2)/(NIR–RE2),(RE3–RE2)/(RE4–RE2),and(NIR–RE2)/(RE4–RE2),retained values within the predefined dust-resistant range over the full dust retention levels of 0–24 g/m^(2),thus showing a more stable dust resistance compared with the commonly used 36 vegetation indices.Specially,(RE3–RE2)/(RE4–RE2)performed the most robustly in Sentinel-2 imagery,that is,58.020%of pixels were within the dust-resistant range,and an average ratio of 0.937 was obtained for the original-spectra index.This study provides a scientific basis for crop monitoring and management in dust-affected regions.
基金National Natural Science Foundation of China(NSFC,Grant No.81273583)
文摘The epidermal growth factor receptor（EGFR）—tyrosine kinase inhibitors（TKIs） monotherapies have limited efficacy in the treatment of EGFR mutation-negative non-small cell lung cancers（NSCLCs）. In the present study, we aimed to investigate the combined effect of erlotinib（ER） and cabozantinib（CAB） on NSCLC cell lines harboring wild-type EGFR and to optimize the dosage regimens using pharmacodynamic（PD） modeling and simulation. Therefore, we examined the combined effect of ER and CAB on cell viability, cloning, apoptosis induction, migration and growth dynamics in H1299 and A549 cells. PD modeling and simulation were also performed to quantitatively describe the H1299 cells growth dynamics and to optimize the dosage regimens as well. Our results showed that CAB effectively enhanced the sensitivity of both cell lines to ER. The PD models fitted the data well, and some important parameters were obtained. The exponential（λ_0） and linear（λ_1） growth rates of H1299 cells were 0.0241 h^（–1） and 360 cells？h^（–1）, respectively. The Emax of ER and CAB was 0.0091 h^（–1） and 0.0085 h^（–1）, and the EC50 was 0.812 μM and 1.16 μM, respectively. The synergistic effect observed in the experiments was further confirmed by the estimated combination index φ（1.37）,（95% confidence interval： 1.24–1.50）, obtained from PD modeling. Furthermore, the dosage regimens were optimized using simulations. In summary, both the experimental and modeling results demonstrated the synergistic interaction between ER and CAB in NSCLCs without EGFR mutations. Sequential combinations of ER and CAB provided an option for the therapy of the NSCLCs with wild-type EGFR, which would provide some references for preclinical study and translational research as well.
基金Project supported by the National High Technology Research and Development Program of China (863 Program) (No. 2003AA209030) High Technology Research and Development Program of Jiangsu Province (No. BG2004320) the National Natural Science Foundation
文摘A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water relations under both drought and waterlogging conditions in two sequential growing seasons from 2000 to 2002, and then the data were used to develop and validate models simulating the responses of winter wheat growth to drought and waterlogging stress. The experiment consisted of four treatments, waterlogging (keep 1 to 2 cm water layer depth above soil surface), control (70%-80% field capacity), light drought (40%-50% field capacity) and severe drought (30%-40% field capacity) with six replicates at five stages in the 2000-2001 growth season. Three soil water content treatments (waterlogging, control and drought) with two replicates were designed in the 2001-2002 growth season. Waterlogging and control treatments are the same as in the 2000-2001 growth season. For the drought treatment, no water was supplied and the soil moisture decreased from field capacity to wilting point. Leaf net photosynthetic rate, transpiration rate, predawn leaf water potential, soil water potential, soil water content and dry matter weight of individual organs were measured. Based on crop-water eco-physiological relations, drought and waterlogging stress factors for winter wheat growth simulation model were put forward. Drought stress factors integrated soil water availability, the sensitivity of different development stages and the difference between physiological processes (such as photosynthesis, transpiration and partitioning). The quantification of waterlogging stress factor considered different crop species, soil water status, waterlogging days and sensitivity at different growth stages. Data sets from the pot experiments revealed favorable performance reliability for the simulation sub-models with the drought and waterlogging stress factors.
基金Project supported by the National Key Basic Research Support Foundation (NKBRSF) of China (No. G199901881).
文摘Six paddy soils of Shanghai, China, were studied after 120 days of anaerobicincubation at 25 deg C and 35 deg C. Four models, the effective accumulated temperature model, theone-component first-order exponential model (the one-pool model), the two-component first-orderexponential model (the two-pool model), and the two-component first-order plus zero-orderexponential model including a constant term (the special model), were fitted to the data of observedmineral-N during incubation using non-linear regression procedures. The two-pool model and thespecial model gave the best fits amongst the four models, and parameters in the special model weremore reasonable than those in the other three. Results showed that the special model gave a betterprediction of nitrogen mineralization under flooded conditions than the other three models.
基金supported in part by the National Key Scientific Instrument and Equipment Development Project(No.61827801)in part by the National Natural Science Foundation of China(No.62271250)+2 种基金in part by Natural Science Foundation of Jiangsu Province(No.BK20211182)in part by the Key Technologies R&D Program of Jiangsu(Prospective and Key Technologies for Industry)under Grants BE2022067 and BE2022067-3in part by China Scholarship Council,and in part by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX220360.
文摘Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency.
基金funded by the National Natural Science Foundation of China (30771277 and 30771279)
文摘Crop performance is determined by the combined effects of the genotype of the crop and the environmental conditions of the production system. This study was undertaken to develop a dynamic model for simulating environmental （temperature and solar radiation） and N supply effects on fiber fineness, maturity and micronaire. Three different experiments involving genotypes, sowing dates, and N fertilization rates were conducted to support model development and model evaluation. The growth and development duration of fiber fineness, maturity, and micronaire were scaled by using physiological development time of secondary wall synthesis （PDT SWSP ）, which was determined based on the constant ratio of SWSP/ BMP. PTP （product of relative thermal effectiveness （RTE） and photosynthetically active radiation （PAR）, MJ m-2） and subtending leaf N content per unit area （N A , g m-2） and critical subtending leaf N content per unit area （CN A , g m-2） of cotton boll were calculated or simulated to evaluate effects of temperature and radiation, and N supply. Besides, the interactions among temperature, radiation and N supply were also explained by piecewise function. The overall performance of the model was calibrated and validated with independent data sets from three field experiments with two sowing dates, three or five flowering dates and three or four N fertilization rates for three subsequent years （2005, 2007, and 2009） at three ecological locations. The average RMSE and RE for fiber fineness, maturity, and micronaire predictions were 372 m g-1 and 5.0%, 0.11 m g-1 and 11.4%, 0.3 m g-1 and 12.3%, respectively, indicating a good fit between the simulated and observed data. It appears that the model can give a reliable prediction for fiber fineness, maturity and micronaire formation under various growing conditions.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KZCX2-YW-Q11-03)the "Strategic Priority Research Program" of the Chinese Academy of Sciences (Grant No. XDA05100502)+2 种基金the National 973 Project of China (Grant No. 2010CB950804)the National Natural Science Foundation of China (GrantNo. 41075106)the Hundred Talents Program of the Chinese Academy of Sciences
文摘In this study, a regional air quality model system （RAQMS） was applied to investigate the spatial distributions and seasonal variations of atmospheric aerosols in 2006 over East Asia. Model validations demonstrated that RAQMS was able to reproduce the evolution processes of aerosol components reasonably well. Ground-level PM10 （particles with aerodynamic diameter ≤10 μm） concentrations were highest in spring and lowest in summer and were characterized by three maximum centers： the Taklimakan Desert （-1000 μg m^-3）, the Gobi Desert （-400 μg m^-3）, and the Huabei Plain （- 300 μg m^-3） of China. Vertically, high PM10 concentrations ranging from 100 μg m-3 to 250 μg m-3 occurred from the surface to an altitude of 6000 m at 30°-45°N in spring. In winter, the vertical gradient was so large that most aerosols were restricted in the boundary layer. Both sulfate and ammonium reached their highest concentrations in autumn, while nitrate reached its maximum level in winter. Black carbon and organic carbon aerosol concentrations reached maximums in winter. Soil dust were strongest in spring, whereas sea salt exerted the strongest influence on the coastal regions of eastern China in summer. The estimated burden of anthropogenic aerosols was largest in winter （1621 Gg） and smallest in summer （1040 Gg）. The sulfate burden accounted for -42% of the total anthropogenic aerosol burden. The dust burden was about twice the anthropogenic aerosol burden, implying the potentially important impacts of the natural aerosols on air quality and climate over East Asia.
文摘OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.
基金This study was co-supported by the National Science and Technology Major Project,China(No.J2019-V-0010-0104)Zhejiang Provincial Natural Science Foundation of China(No.LQ23E060007).
文摘As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With the rapid development of advanced high-performance aeroengine,the increasing demand of high-altitude simulation test is driving AGTF to improve its test ability and level of automation and intelligence.The modeling method,simulation tool,and control technology are the key factors to support the improvement of the AGTF control system.The main purpose of this paper is to provide an overview of modeling methods,simulation tools,and control technologies in AGTF control system for future research.First,it reviews the evolution of AGTF in the world,from the early formative stage to integration stage.Then,the mathematical modeling method of AGTF for control application is overviewed.Furthermore,the simulation tools used in the AGTF control system are overviewed from numerical simulation to hardware-in-loop simulation and further to semi-physical simulation.Meanwhile,the control technologies used in the AGTF control system are summarized from single-variable control to multivariable integrated control,and from classical control theory to modern control theory.Finally,recommendations for future research are outlined.Therefore,this review article provides extensive literature information for the modeling,simulation,and control design of AGTF for control application.
基金the Major Program of National Natural Science Foundation of China(51490683).
文摘Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments.
基金Project supported by the National Natural Science Foundation ofChina (No. 40171047) and the Doctoral Foundation of NationalEducation Ministry China
文摘Simulation models of heat and water transport have not been rigorously tested for the red soils of southern China. Based on the theory of nonisothermal water-heat coupled transfer, a simulation model, programmed in Visual Basic 6.0, was developed to predict the coupled transfer of water and heat in hilly red soil. A series of soil column experiments for soil water and heat transfer, including soil columns with closed and evaporating top ends, were used to test the simulation model. Results showed that in the closed columns, the temporal and spatial distribution of moisture and heat could be very well predicted by the model, while in the evaporating columns, the simulated soil water contents were somewhat different from the observed ones. In the heat flow equation by Taylor and Lary (1964), the effect of soil water evaporation on the heat flow is not involved, which may be the main reason for the differences between simulated and observed results. The predicted temperatures were not in agreement with the observed one with thermal conductivities calculated by de Vries and Wierenga equations, so that it is suggested that Kh, soil heat conductivity, be multiplied by 8.0 for the first 6.5 h and by 1.2 later on. Sensitivity analysis of soil water and heat coefficients showed that the saturated hydraulic conductivity, KS, and the water diffusivity, D(θ), had great effects on soil water transport; the variation of soil porosity led to the difference of soil thermal properties, and accordingly changed temperature redistribution, which would affect water redistribution.
文摘Accurate acid placement constitutes a major concern in matrix stimulation because the acid tends to penetrate the zones of least resistance while leaving the low-permeability regions of the formation untreated.Degradable materials(fibers and solid particles)have recently shown a good capability as fluid diversion to overcome the issues related to matrix stimulation.Despite the success achieved in the recent acid stimulation jobs stemming from the use of some products that rely on fiber flocculation as the main diverting mechanism,it was observed that the volume of the base fluid and the loading of the particles are not optimized.The current industry lacks a scientific design guideline because the used methodology is based on experience or empirical studies in a particular area with a particular product.It is important then to understand the fundamentals of how acid diversion works in carbonates with different diverting mechanisms and diverters.Mathematical modeling and computer simulations are effective tools to develop this understanding and are efficiently applied to new product development,new applications of existing products or usage optimization.In this work,we develop a numerical model to study fiber dynamics in fluid flow.We employ a discrete element method in which the fibers are represented by multi-rigid-body systems of interconnected spheres.The discrete fiber model is coupled with a fluid flow solver to account for the inherent simultaneous interactions.The focus of the study is on the tendency for fibers to flocculate and bridge when interacting with suspending fluids and encountering restrictions that can be representative of fractures or wormholes in carbonates.The trends of the dynamic fiber behavior under various operating conditions including fiber loading,flow rate and fluid viscosity obtained from the numerical model show consistency with experimental observations.The present numerical investigation reveals that the bridging capability of the fiber–fluid system can be enhanced by increasing the fiber loading,selecting fibers with higher stiffness,reducing the injection flow rate,reducing the suspending fluid viscosity or increasing the attractive cohesive forces among fibers by using sticky fibers.
基金The National Natural Science Foundation of China(No.61273138,61573197)the National Key Technology R&D Program(No.2015BAK06B04)+1 种基金the Key Fund of Tianjin(No.14JCZDJC39300)the Key Technologies R&D Program of Tianjin(No.14ZCZDSF00022)
文摘In order to better study the dynamic characteristics and the control strategy of parafoil systems,considering the effect of flap deflection as the control mechanism and regarding the parafoil and the payload as a rigid body,a six degrees-of-freedom(DOF)dynamic model of a parafoil system including three DOF for translational motion and three DOF for rotational motion,is established according to the K rchhoff motion equation.Since the flexible winged paafoil system flying at low altitude is more susceptibleto winds,the motion characteristics of the parafoil system Wth and Wthout winds are simulated and analyzed.Furthermore,the ardropm test is used to further verify the model.The comparison results show that the simulation trajectory roughly overlaps with the actual flight track.The horzontnl velocity of the simulation model is in good accordance with the airdrop test,with a deviation less than0.5m/s,while its simulated vertical velocity fuctuates slightly under the infuence of the wind,and shows a similar trend to the ardrop test.It is concludedthat the established model can well describe the characteristics of the parafoil system.
基金supported by 985 Program of Zhejiang University under Grant No.188020+193432602/215National Natural Science Foundation of China (Grant No.41175047)+3 种基金the R&D Special Fund for Public Welfare Industry by the Ministry of Finance and the Ministry of Science and Technology (Grant Nos.GYHY201006014 and 20100503310)the Basic Research Project of the State Key Laboratory of Severe Weather (12011LAS-B14)supported by the National Key Basic Research and Development Project of China under Grant Nos.2013CB430103 and 2011CB403405the National Natural Science Foundation of China under Grant Nos.41375058 and 41175065
文摘ABSTRACT Rainfall responses to doubled atmospheric carbon dioxide concentration were investigated through the analysis of two pairs of two-dimensional cloud-resolving model sensitivity experiments. One pair of experiments simulated pre-summer heavy rainfall over southern China around the summer solstice, whereas the other pair of experiments simulated tropical rainfall around the winter solstice. The analysis of the time and model domain mean heat budget revealed that the enhanced local atmospheric warming was associated with doubled carbon dioxide through the weakened infrared radiative cooling during the summer solstice. The weakened mean pre-summer rainfall corresponded to the weakened mean infrared radiative cooling. Doubled carbon dioxide increased the mean tropical atmospheric warming via the enhanced mean latent heat in correspondence with the strengthened mean infrared radiative cooling during the winter solstice. The enhanced mean tropical rainfall was associated with the increased mean latent heat.
