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Characterization of the effects of hyaluronan oligosaccharides on human gut microbiota using a simulated batch fermentation system
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作者 Xinwei Gao Hongkang Zhu +6 位作者 Litao Hu Jieyu Sun Wenjie Zuo Ping Liu Yang Wang Guocheng Du Zhen Kang 《Food Science and Human Wellness》 2025年第6期2172-2184,共13页
The prebiotic effects of hyaluronan(HA)are widely recognized,contributing to improved gut health and immune modulation.Despite its extensive use as dietary supplement,the specific interactions between HA oligosacchari... The prebiotic effects of hyaluronan(HA)are widely recognized,contributing to improved gut health and immune modulation.Despite its extensive use as dietary supplement,the specific interactions between HA oligosaccharides(o-HAs)and the gut microbiome remain largely unexplored.To investigate its role and metabolic fate in gut homeostasis,200 mg/day of o-HAs(average molecule weight 1 kDa)were added to an automated computer-controlled SIMulator of the Gastrointestinal tract(SIMGI).The results revealed a significant reshaping of the intestinal flora composition by o-HAs,notably reducing the Firmicutes/Bacteroides ratio.Fermentation of o-HAs by gut microbiota significantly increased the abundance of Bifidobacterium,Prevotellaceae_Prevotella,Dialister,Eubacterium,and Sutterella,but decreased that of Catenibacterium,Oscillospira,Klebsiella,and Citrobacter(P<0.05).This corresponded with significant enhancements in the content of short-chain fatty acids(SCFAs)such as acetic acid,propionic acid and n-butyric acid,highlighting the significant impact of o-HAs at the genus level.Furthermore,analysis of microbial function predicted the downregulation of pathological events in nine human diseases,particularly infectious ones(parasitic and bacterial).Potential inhibitions were observed in metabolic pathways associated with pentose and glucuronate interconversions as well as cationic antimicrobial peptide resistance.These findings underscore the in vitro prebiotic effects of o-HAs and their potential relevance in managing diverticular diseases or preventing metabolic disorders through the regulation of gut microbiota. 展开更多
关键词 Hyaluronan oligosaccharides Colon simulation system FERMENTATION Fecal microbiota Short chain fatty acid
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Multi-Objective Optimization of Phase Change Coupled Thermal Management System Based on NSWOA
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作者 Yang Yang Zhenhai Gao +2 位作者 Zehao Kang Keyuan Shi Peng Guo 《Energy & Environmental Materials》 2026年第1期74-91,共18页
This study investigates phase change materials(PCMs)for lithium battery thermal management.A PCM cooling model was developed and experimentally validated,showing≤1.5 K temperature error and≤5%PCM melting simulation ... This study investigates phase change materials(PCMs)for lithium battery thermal management.A PCM cooling model was developed and experimentally validated,showing≤1.5 K temperature error and≤5%PCM melting simulation deviation.A non-uniform battery arrangement was proposed to optimize temperature distribution.Key PCM parameters(melting point,conductivity,latent heat)were analyzed for thermal performance.A hybrid liquid-PCM cooling system was designed and optimized via an entropy-weighted TOPSIS-NSWOA strategy.At 4 C discharge,the optimized system achieved 311.41 K maximum temperature(5.89 K reduction)and 4.71 K temperature difference,meeting 18650 battery safety standards.The findings guide PCM selection and integrated thermal management design,balancing heat dissipation and temperature uniformity. 展开更多
关键词 BATTERIES MODELING SIMULATION
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A methodology for constructing the system-of-systems environment to evaluate UAV decision systems
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作者 Zhiqi Liu Mingqiang Luo +4 位作者 Yulu Ma Chenguang Xing Ruo Wang Daheng Chen Xiaolu Wang 《Defence Technology(防务技术)》 2026年第2期337-351,共15页
Evaluating Unmanned Aerial Vehicle(UAV)systems within a System-of-Systems(SoS)environment helps clarify their contribution to the overall combat capability and supports effectiveness-oriented system optimization.When ... Evaluating Unmanned Aerial Vehicle(UAV)systems within a System-of-Systems(SoS)environment helps clarify their contribution to the overall combat capability and supports effectiveness-oriented system optimization.When assessing decision systems in such an environment,cross-level modeling and simulation are required,which often face a trade-off between low modeling cost and high simulation accuracy,while the credibility of results remains challenging to ensure.To address these issues,this study proposes a hybrid-granularity Hardware-In-the-Loop(HIL)SoS environment construction method based on Graphical Evaluation and Review Technique(GERT).The method employs GERT to analyze the relationships between simulation systems,the System Under Test(SUT),and mission outcomes,thereby determining the required model precision for different systems.A dynamic resource allocation algorithm is applied to adjust model granularity on demand,ensuring high-fidelity simulation under constrained total cost.Additionally,GERT estimates the computational frequency and communication bandwidth requirements of the SUT,guiding hardware selection to enhance simulation credibility.A UAV maritime combat case study was conducted for validation.The results demonstrate that,compared to the flat modeling approach,the hybrid-granularity scenario based on GERT analysis achieves higher simulation accuracy with lower overall model complexity.The coefficient of variation in evaluation results significantly decreases in HIL simulations compared to virtual simulations,confirming improved credibility.Under the hybrid-granularity HIL scenario,the decision system was evaluated from an effectiveness perspective,identifying the most sensitive performance parameter.Subsequent targeted optimization led to an 11.90%improvement in effectiveness,validating the method's practical utility. 展开更多
关键词 system-of-systems Unmanned aerial vehicle Decision system HARDWARE-IN-THE-LOOP Hybrid-granularity simulation
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Implementation of Hysteretic Models into Mechanical Systems for the Purpose of Digital Twin Modelling to Support the Technical Diagnostics
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作者 Milan Sága Ján Minárik +1 位作者 Milan Vaško Jaroslav Majko 《Computer Modeling in Engineering & Sciences》 2026年第3期477-508,共32页
The presented study analyses the impact of hysteresis on the response of mechanical systems.The main objective is to determine how the hysteretic models influence the system behaviour and if they can be utilised to de... The presented study analyses the impact of hysteresis on the response of mechanical systems.The main objective is to determine how the hysteretic models influence the system behaviour and if they can be utilised to describe a damaged or a faulty system.The hysteretic models are able to describe various types of nonlinear behaviour that can reflect the wear or damage of the system components.The data obtained from these models can possibly serve as a basis for the advanced approaches,such as digital twin modelling and predictive maintenance.All the results presented in this study were obtained in the MATLAB environment.The first part of the study provides a concise review of hysteretic models and compares them under the condition of equal energy dissipation per loading cycle.The models considered include the linear,bilinear,Bouc-Wen,Wang-Wen,and generalised Bouc-Wen models.The second part focuses on the development of a mechanical model and the implementation of the mentioned hysteretic models.The stochastic modelling of the driving forces is carried out using the Kanai-Tajimi differential model.The results show that the hysteretic models noticeably influence the treated model.This is also reflected in the frequency domain.The behaviour of hysteretic systems suggests increased energy dissipation combined with the changes in stiffness of the suspension components.Among the presented models,the asymmetric models can be considered as the most suitable for further modelling of damaged systems. 展开更多
关键词 HYSTERESIS vibrations multibody dynamics numerical simulation digital twin modelling technical diagnostics
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Approach on enhancing the air conditioning system to improve the winter thermal environment in Eastern China Region's airport terminals
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作者 Pengyu Yan Fei Yu +5 位作者 Shenyi Cui Jianjie Ma Zepeng Zhu Yun Cai Xin Zhou Chanjuan Sun 《Energy and Built Environment》 2026年第1期239-252,共14页
Passengers typically spend much time in commercial zones of terminals for retail,meals,and other services.Enhancing the study of thermal comfort in this local space is necessary.The climate in the Eastern China Region... Passengers typically spend much time in commercial zones of terminals for retail,meals,and other services.Enhancing the study of thermal comfort in this local space is necessary.The climate in the Eastern China Region is variable and complex,making it more challenging to maintain the indoor thermal environment.This study conducted field measurements in winter in a commercial zone of one terminal to assess the thermal environment.Numerical simulations and PMV-PPD analyses were performed using the Computational Fluid Dynamics(CFD)program The results showed that the overall humidity in the commercial zone was low.There were notable differences in the temperatures and velocities of supply air among different air vents on the commercial island.Based on these initial conditions obtained by measurements,the simulations showed that localized areas under the breathing plane are either too hot(24℃and above)or too cold(18℃and below).The dissatisfaction percentage of the population exceeds 27%.This paper proposed that through enhancements in the air vent dimensions,layout,and air supply conditions,the temperature can be maintained in the range of 20-24℃.Furthermore,the PMV could be controlled within the range of-0.5 to 0.5.PPD was below 10%,reflecting compliance with Class I heating standards.Overall,findings from this study provide a less costly modification for thermal comfort improvement in commercial zones,and serve as a reference for the design and operation of air-conditioning systems to ensure thermal comfort in airport terminals’commercial zones. 展开更多
关键词 Terminal building Field measurement Numerical simulation Thermal comfort
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Effects of forest and simulated nature meditation on university students'well-being
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作者 Yawei Wei Won Sop Shin +2 位作者 Michael Lee Tahia Devisscher Guangyu Wang 《Journal of Forestry Research》 2026年第1期23-41,共19页
The rise in urbanization has increasingly restricted access to natural environments,posing substantial risks to the physical and mental health of urban populations,including university students and other high-stress g... The rise in urbanization has increasingly restricted access to natural environments,posing substantial risks to the physical and mental health of urban populations,including university students and other high-stress groups.This study examines the comparative effects of outdoor forest meditation(OFM)and indoor nature meditation(INM)in simulated nature environments(SNEs)on the physiological and psychological health of university students.A pretestposttest repeated measures design was employed,with 40students participating in three replicated OFM sessions and three identical INM sessions across varied SNE settings.Key physiological metrics,including heart rate(HR),blood pressure(BP),and salivary amylase concentration(SAC),were measured before and after each session.Psychological well-being was assessed using the Perceived Stress Scale-10(PSS-10)and Profile of Mood States(POMS).Results revealed significant reductions(p<0.05)in most post-intervention outcomes,except in the second indoor session across physiologic al and psychologic al responses,while multi-sensory INM sessions produced comparable benefits.Notably,SNEs with enhanced sensory components were effective,though slightly less impactful than OFM.These findings suggest that both OFM in nature and INM in SNEs can benefit university students'well-being.INM in SNEs offers a promising alternative for those with limited access to natural settings,contributing meaningfully to stress reduction and overall well-being.This study highlights the potential for nature-based strategies for human health in urban centres,advocating for further investigation into the long-term impacts of SNEs and optimal sensory configurations for maximizing therapeutic effects in urban populations. 展开更多
关键词 Nature exposure MEDITATION simulated nature Physiological health Mental health Stress reduction Human well-being
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Characteristics of gas−liquid flow in double-side-blown systems computed by CFD
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作者 Wei WANG Hong-liang ZHAO +1 位作者 Feng-qin LIU Hong Yong SOHN 《Transactions of Nonferrous Metals Society of China》 2026年第2期659-676,共18页
A CFD-based numerical model was employed to quantitatively analyze the flow characteristics of double-side-blown gas−liquid flow.Key parameters were extracted,and Spearman correlation analysis was used to quantify the... A CFD-based numerical model was employed to quantitatively analyze the flow characteristics of double-side-blown gas−liquid flow.Key parameters were extracted,and Spearman correlation analysis was used to quantify the relationships among bubble behavior,circulating flow,and liquid oscillations.The results show that periodic bubble behavior under steady injection drives the circulating flow of the liquid on both sides.The asynchronism of bubble behavior on both sides results in the alternation of circulating intensity,which significantly enhances gas−liquid mixing efficiency at certain liquid levels of 200 and 220 mm.Flow patterns of the double-side-blown process are classified into weak circulation,strong−weak alternating circulation,and strong circulation modes based on the influence of circulating flows on the penetration depth.The penetration depth in the strong−weak alternating circulation mode is generally greater than that in the single-side-blown process.The imbalance of circulating intensities on both sides primarily leads to the stable fluctuation in the injecting direction,which reveals the appearance of periodic oscillations in the molten bath.The effect of control parameters such as liquid level and gas flow rate on the liquid oscillations were discussed. 展开更多
关键词 numerical simulation side-blown furnace flow characteristics bubble behavior penetration depth Spearman correlation analysis
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Nonlinear mechanical analysis of load-bearing characteristics of coal-support-backfill system crossing abandoned roadways
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作者 Jun Guo Zi Wang +8 位作者 Guorui Feng Jinwen Bai Xiaoze Wen Wenbo Huang Jie Zhang Wenming Feng Quan Liu Jiahao Zhang Longlong Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期246-264,共19页
Roof pre-fracture poses a considerable risk during the re-mining of residual coal above abandoned roadways,threatening the safety of the mining faces.This study employs a Winkler foundation beam model for mechanical a... Roof pre-fracture poses a considerable risk during the re-mining of residual coal above abandoned roadways,threatening the safety of the mining faces.This study employs a Winkler foundation beam model for mechanical analysis of roof structures and adopts a multivariate nonlinear analysis approach to explore the synergistic load-bearing effects within the'coal pillar-support-backfill body'system during the fill and re-mining processes above these roadways.The findings demonstrate that backfill mining significantly reduces stress concentrations in coal pillars and reduces excessive bending moments in roofs near abandoned roadways.The roof deflection equation incorporates three critical factors affecting stability during backfill mining:the width of the coal pillar(L_(3)),the working resistance of the support(q_(z)),and the elastic foundation coefficient of the backfill material(kcÞ.Under single-factor conditions,the impact sequence on roof stability in the coal pillar zone is·k_(c)>L_(3)>q_(z).Further,multivariate nonlinear analysis reveals the interactions within the'coal-support-backfill'structure,indicating that in terms of roof control,the interaction terms are ordered as L_(3)·k_(c)>q_(z)·k_(c)>L_(3)q_(z).Therefore,priority should be given to adjusting the coal pillar width and backfill strength,followed by modifications to the support resistance and backfill strength during the recovery of abandoned roadways.An improved understanding of these interactions will help optimize strategies for the recovery of residual coal through abandoned roadways,thereby enhancing the stability and safety of mining operations under complex geological conditions. 展开更多
关键词 Filling re-mining Coal pillar instability Abandoned roadway crossing Similar simulation Synergistic load-bearing
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Automatic gating and riser system design and defect control for K4169 superalloy guide blade casting based on parametric 3D modeling-simulation integrated system
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作者 Le-chuan Li Ya-jun Yin +4 位作者 Bing-zheng Fan Guo-yan Shui Xiao-yuan Ji Jian-xin Zhou Lei Jin 《China Foundry》 2026年第1期20-30,共11页
Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical si... Automation and intelligence have become the primary trends in the design of investment casting processes.However,the design of gating and riser systems still lacks precise quantitative evaluation criteria.Numerical simulation plays a significant role in quantitatively evaluating current processes and making targeted improvements,but its limitations lie in the inability to dynamically reflect the formation outcomes of castings under varying process conditions,making real-time adjustments to gating and riser designs challenging.In this study,an automated design model for gating and riser systems based on integrated parametric 3D modeling-simulation framework is proposed,which enhances the flexibility and usability of evaluating the casting process by simulation.Firstly,geometric feature extraction technology is employed to obtain the geometric information of the target casting.Based on this information,an automated design framework for gating and riser systems is established,incorporating multiple structural parameters for real-time process control.Subsequently,the simulation results for various structural parameters are analyzed,and the influence of these parameters on casting formation is thoroughly investigated.Finally,the optimal design scheme is generated and validated through experimental verification.Simulation analysis and experimental results show that using a larger gate neck(24 mm in side length) and external risers promotes a more uniform temperature distribution and a more stable flow state,effectively eliminating shrinkage cavities and enhancing process yield by 15%. 展开更多
关键词 numerical simulation automatic design investment casting parametric 3D modeling gating and riser system
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Improved simulated annealing algorithm for UAV path planning with uncertain flight time
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作者 LI Xiaoduo LUO He +1 位作者 WANG Guoqiang YIN Youlong 《Journal of Systems Engineering and Electronics》 2026年第1期272-286,共15页
Efficient multiple unmanned aerial vehicles(UAVs)path planning is crucial for improving mission completion efficiency in UAV operations.However,during the actual flight of UAVs,the flight time between nodes is always ... Efficient multiple unmanned aerial vehicles(UAVs)path planning is crucial for improving mission completion efficiency in UAV operations.However,during the actual flight of UAVs,the flight time between nodes is always influenced by external factors,making the original path planning solution ineffective.In this paper,the multi-depot multi-UAV path planning problem with uncertain flight time is modeled as a robust optimization model with a budget uncertainty set.Then,the robust optimization model is transformed into a mixed integer linear programming model by the strong duality theorem,which makes the problem easy to solve.To effectively solve large-scale instances,a simulated annealing algorithm with a robust feasibility check(SA-RFC)is developed.The numerical experiment shows that the SA-RFC can find high-quality solutions within a few seconds.Moreover,the effect of the task location distribution,depot counts,and variations in robustness parameters on the robust optimization solution is analyzed by using Monte Carlo experiments.The results demonstrate that the proposed robust model can effectively reduce the risk of the UAV failing to return to the depot without significantly compromising the profit. 展开更多
关键词 unmanned aerial vehicle(UAV)path planning uncertain flight time robust optimization simulated annealing
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Forecasting ecosystem service values in South China's fragile mountain regions:a multi-scenario analysis with adaptive land use valuation
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作者 LIAO Zhaoyang YU De +3 位作者 RAN Penglai ZHENG Defu SHANG Guiduo TAN Jie 《Journal of Mountain Science》 2026年第2期813-827,共15页
Numerous economically underdeveloped and ecologically fragile areas in southern China's mountainous regions face increasing challenges in achieving sustainable development. A comparative analysis of ecosystem serv... Numerous economically underdeveloped and ecologically fragile areas in southern China's mountainous regions face increasing challenges in achieving sustainable development. A comparative analysis of ecosystem service responses to land use scenarios, incorporating adaptive valuation coefficients, can reveal actionable pathways to reconcile sustainable development and ecological conservation in mountainous regions. In this study, the ecosystem service value(ESV) dynamics in the Hunan–Jiangxi Border Region(HJBR), which is a representative old revolutionary base with a relatively undeveloped economy, were investigated by integrating historical land use data analysis from 2000 to 2020 and adopting patch-generating land use simulation(PLUS) modelling. Three policy-responsive scenarios, namely, natural growth(NGS), farmland protection(FPS), and ecological protection(EPS), were systematically developed to project ESV variations for 2030 and 2040. Our analysis revealed that from 2000 to 2020, urban sprawl and water body expansion occurred at the expense of forestland, cultivated land, and grassland, yet yield-driven productivity improvements increased the ESV by 227.30%(equivalent to ¥250.0 billion). By 2040, the NGS achieves the greatest ESV increase(¥189.895 billion) while fully accommodating urban land demand;the FPS yields the smallest ESV increase(¥148.169 billion), with the EPS occupying an intermediate position(¥182.207 billion). Climate regulation and hydrological services dominate ecological functions, collectively exceeding 49% across all the scenarios and periods. By 2040, most service functions exhibit growth trends except for a 0.30% water supply decline under the FPS, whereas the EPS demonstrates balanced development through multidimensional service enhancements. These findings underscore the necessity of integrating ecological safeguards into land use planning frameworks to ensure sustainable regional development. 展开更多
关键词 Ecosystem service value(ESV) Multiscenario simulation PLUS model LUCC Mountainous Regions Hunan–Jiangxi Border Region(HJBR)
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A Stochastic Optimal Control for a Class of LTI Systems With a State-Dependent Wiener Process:An Algebraic Approach
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作者 Kento Fujita Daisuke Tsubakino Shiuji Hara 《IEEE/CAA Journal of Automatica Sinica》 2026年第2期489-491,共3页
Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in a... Dear Editor,In this letter,we focus on the algebraic relationship between the coefficient matrices and the solution of the stochastic algebraic Riccati equation.It is revealed that,if the coefficient matrices are in an algebra,then the solution(and also the control gain in many cases)is also in the same algebra.The main result is verified by a numerical simulation. 展开更多
关键词 stochastic optimal control algebraic relationship algebraic approach state dependent Wiener process coefficient matrices stochastic algebraic Riccati equation numerical simulation stochastic algebraic riccati equationit
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Changes in Winter Stratospheric Circulation in CMIP5 Scenarios Simulated by the Climate System Model FGOALS-s2 被引量:9
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作者 任荣彩 杨扬 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2012年第6期1374-1389,共16页
Diagnosis of changes in the winter stratospheric circulation in the Fifth Coupled Model Intercomparison Project (CMIP5) scenarios simulated by the Flexible Global Ocean-Atmosphere-Land System model, second version s... Diagnosis of changes in the winter stratospheric circulation in the Fifth Coupled Model Intercomparison Project (CMIP5) scenarios simulated by the Flexible Global Ocean-Atmosphere-Land System model, second version spectrum (FGOALS-s2), indicates that the model can generally reproduce the present climatology of the stratosphere and can capture the general features of its long-term changes during 1950-2000, including the global stratospheric cooling and the strengthening of the westerly polar jet, though the simulated polar vortex is much cooler, the jet is much stronger, and the projected changes are generally weaker than those revealed by observation data. With the increase in greenhouse gases (GHGs) effect in the historical simu- lation from 1850 to 2005 (called the HISTORICAL run) and the two future projections for Representative Concentration Pathways (called the RCP4.5 and RCP8.5 scenarios) from 2006 to 2100, the stratospheric response was generally steady, with an increasing stratospheric cooling and a strengthening polar jet ex- tending equatorward. Correspondingly, the leading oscillation mode, defined as the Polar Vortex Oscillation (PVO), exhibited a clear positive trend in each scenario, confirming the steady strengthening of the polar vortex. However, the positive trend of the PVO and the strengthening of the polar jet were not accompa- nied by decreased planetary-wave dynamical heating, suggesting that the cause of the positive PVO trend and the polar stratospheric cooling trend is probably the radiation cooling effect due to increase in GHGs. Nevertheless, without the long-term linear trend, the temporal variations of the wave dynamic heating, the PVO, and the polar stratospheric temperature are still closely coupled in the interannual and decadal time scales. 展开更多
关键词 simulated changes STRATOSPHERE CMIP5 FGOALS-s2
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Multiobjective Optimization of Simulated Moving Bed by Tissue P System 被引量:8
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作者 黄亮 孙磊 +1 位作者 王宁 金晓明 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第5期683-690,共8页
The binaphthol enantiomers separation process using simulation moving bed technology is simulated with the true moving bed approach (TMB). In order to systematically optimize the process with multiple productive obj... The binaphthol enantiomers separation process using simulation moving bed technology is simulated with the true moving bed approach (TMB). In order to systematically optimize the process with multiple productive objectives, this article develops a variant of tissue P system (TPS). Inspired by general tissue P systems, the special TPS has a tissue-like structure with several membranes. The key rules of each membrane are the communication rule and mutation rule. These characteristics contribute to the diversity of the population, the conquest of the multimodal of objective function, and the convergence of algorithm. The results of comparison with a popular algorithm——the non-dominated sorting genetic algorithm 2(NSGA-2) illustrate that the new algorithm has satisfactory performance. Using the algorithm, this study maximizes synchronously several conflicting objectives, purities of different products, and productivity. 展开更多
关键词 simulated moving bed tissue P systems multiobjective optimization Pareto optimality evolutionary algorithm binaphthol enantiomers separation process
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Cascade refrigeration system synthesis based on hybrid simulated annealing and particle swarm optimization algorithm 被引量:3
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作者 Danlei Chen Yiqing Luo Xigang Yuan 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第6期244-255,共12页
Cascade refrigeration system(CRS)can meet a wider range of refrigeration temperature requirements and is more energy efficient than single-refrigerant refrigeration system,making it more widely used in low-temperature... Cascade refrigeration system(CRS)can meet a wider range of refrigeration temperature requirements and is more energy efficient than single-refrigerant refrigeration system,making it more widely used in low-temperature industry processes.The synthesis of a CRS with simultaneous consideration of heat integration between refrigerant and process streams is challenging but promising for significant cost saving and reduction of carbon emission.This study presented a stochastic optimization method for the synthesis of CRS.An MINLP model was formulated based on the superstructure developed for the CRS,and an optimization framework was proposed,where simulated annealing algorithm was used to evolve the numbers of pressure/temperature levels for all sub-refrigeration systems,and particle swarm optimization algorithm was employed to optimize the continuous variables.The effectiveness of the proposed methodology was verified by a case study of CRS optimization in an ethylene plant with 21.89%the total annual cost saving. 展开更多
关键词 Optimal design Process systems Particle swarm optimization simulated annealing Mathematical modeling
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Effects of simulated microgravity on antioxidant system in testis of adult rats 被引量:2
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作者 Dangxia Zhou Shudong Qiu Ying Sun Jie Zhang Haixue Wang 《Journal of Nanjing Medical University》 2006年第4期234-237,共4页
Objective: To study the effects of simulated microgravity induced by tail-suspension on histological structures and antioxidant system in testis of adult rats. Methods: Forty Spraque-Dawley adult male rats were rand... Objective: To study the effects of simulated microgravity induced by tail-suspension on histological structures and antioxidant system in testis of adult rats. Methods: Forty Spraque-Dawley adult male rats were randomly divided into four groups, two experimental groups and two synchronic control groups. Rats in the two experimental groups were tail-suspended for 14 d and 28 d respectively, then serum hormone, testicular morphology and biochemical changes were evaluated. Results: Compared with the synchronic controls, serum testosterone (T) levels and testicular superoxide dismutase (SOD) significantly decreased(P 〈 0.05), while testicular malondialdehyde(MDA) significantly increased (P 〈 0.05) in tail-suspended rats. The changes were more prominent in the 28 d tail-suspended rats. In addition, hematoxylin and eosin (HE) staining showed that seminiferous tubules atrophied, spermatogenic cells decreased, and seminiferous epithelial cells disintegrated and shed, abnormal multinucleated giant cells appeared and the lumina were azoospermic in tail-suspended rats. ConcIusion: Simulated microgravity induced by tailsuspension has a harmful effect on male reproduction of adult rats by decreasing the ability of testicular antioxidant defense. 展开更多
关键词 simulated microgravity TAIL-SUSPENSION TESTIS RAT oxidative stress
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Understanding Simulated Causes of Damaging Surface Winds in a Derecho-Producing Mesoscale Convective System near the East China Coast Based on Convection-Permitting Simulations 被引量:1
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作者 Liping LUO Ming XUE +3 位作者 Xin XU Lijuan LI Qiang ZHANG Ziqi FAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第11期2112-2130,共19页
A mesoscale convective system(MCS) occurred over the East China coastal provinces and the East China Sea on 30April 2021, producing damaging surface winds near the coastal city Nantong with observed speeds reaching 45... A mesoscale convective system(MCS) occurred over the East China coastal provinces and the East China Sea on 30April 2021, producing damaging surface winds near the coastal city Nantong with observed speeds reaching 45 m s^(–1). A simulation using the Weather Research and Forecasting model with a 1.5-km grid spacing generally reproduces the development and subsequent organization of this convective system into an MCS, with an eastward protruding bow segment over the sea. In the simulation, an east-west-oriented high wind swath is generated behind the gust front of the MCS. Descending dry rear-to-front inflows behind the bow and trailing gust front are found to feed the downdrafts in the main precipitation regions. The inflows help to establish spreading cold outflows and enhance the downdrafts through evaporative cooling. Meanwhile, front-to-rear inflows from the south are present, associated with severely rearward-tilted updrafts initially forming over the gust front. Such inflows descend behind(north of) the gust front, significantly enhancing downdrafts and near-surface winds within the cold pool. Consistently, calculated trajectories show that these parcels that contribute to the derecho originate primarily from the region ahead(south) of the east-west-oriented gust front, and dry southwesterly flows in the low-to-middle levels contribute to strong downdrafts within the MCS. Moreover, momentum budget analyses reveal that a large westward-directed horizontal pressure gradient force within the simulated cold pool produced rapid flow acceleration towards Nantong. The analyses enrich the understanding of damaging wind characteristics over coastal East China and will prove helpful to operational forecasters. 展开更多
关键词 damaging surface winds convection-permitting simulations mesoscale convective system gust front cold pool
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Quilitative Analysis of a Class of Simulate Seasons Environm ent Chem ostat Systems 被引量:1
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作者 宋国华 杨晓忠 李秀琴 《Chinese Quarterly Journal of Mathematics》 CSCD 1998年第4期77-82, ,共6页
In this paper, a class of chemostat systems with simulate seasons Environment in the following form =(1+be(t)-s)Q+x(msa+s-k) =x(msa+s-k)-Qxis discussed. It is abstained that the system has not periodic solution when b... In this paper, a class of chemostat systems with simulate seasons Environment in the following form =(1+be(t)-s)Q+x(msa+s-k) =x(msa+s-k)-Qxis discussed. It is abstained that the system has not periodic solution when b=0; if b≠0 and b1 then system has 2 π periodic solution of system. globally asymptotically stable as mQ<μ *-1 and is unstable as mQ>μ *-1 and there exists at last one minimal 2 π periodic solution (s(t),x(t)) with \{x(t)>0,\}0<s(t)<s *(t). 展开更多
关键词 simulate seasons environment periodic solution quilitative analysis
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The Development of a Simulated Sediment Dosing Apparatus for Deposition Research in Wastewater Collection Systems 被引量:1
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作者 David Campbell Sean Mushin Craig Saunders 《Journal of Water Resource and Protection》 2018年第5期493-506,共14页
Water conservation initiatives promote installation of water efficient and low-flow appliances in waste water collection systems. This has resulted in lower flow rates in those systems than the intended design loading... Water conservation initiatives promote installation of water efficient and low-flow appliances in waste water collection systems. This has resulted in lower flow rates in those systems than the intended design loading, causing solid deposition and sedimentation in some areas. A joint UKWIR/EPSRC CASE grant (14440031) has funded the work described in this paper which investigates sedimentation and solid deposition in building drainage system pipes. The purpose of this paper is to detail the design, calibration and operation of a sediment dosing apparatus to simulate sedimentation rates and explore possible solutions to this issue with a full scale laboratory model based on real site data. The methodology adopted is an experimental approach, where tests have been conducted on the sediment dosing apparatus based on calculations and observations to determine an appropriate sediment dosing regime representative of typical systems. Further tests were conducted with the addition of everyday household products to investigate their effects on sedimentation. The results indicated that a suitable dosing rate was approximately 12% weight-to-volume (w/v) of a fine sand with a known particle size distribution, diluted 1:5 in a clean water base flow. It was also shown that the addition of the household products added to the problem of sedimentation within drainage systems. The results give excellent correlation to real site data, with deposition depth and distribution comparable to measured site data to within 10%. The deposition was achieved within three hours, which approximated six weeks deposition in the live site used in the study. This straightforward investigation details the design, construction and testing of a device to cause accelerated sedimentation in a full scale model of a building drainage system. This is the first step in the process of updating research underpinning our understanding of the behaviour of these systems under conditions of low flow rates caused by water conservation, sedimentation, and the use of common household additives. It will be used to improve simulation of water flow and solid transport in sediment-laden systems. Specifically, the results will be used to determine refinements required to a specific drainage simulation model (DRAINET), which currently has an unquantified sedimentation component. This work is part of a larger body of current research funded by two joint EPSRK/UKWIR grants. 展开更多
关键词 Water CONSERVATION DEPOSITION Modelling Computer Simulation Empirical Model SITE Sampling
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Video-assisted bystander cardiopulmonary resuscitation improves the quality of chest compressions during simulated cardiac arrests: A systemic review and meta-analysis 被引量:1
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作者 Dong-Feng Pan Zheng-Jun Li +2 位作者 Xin-Zhong Ji Li-Ting Yang Pei-Feng Liang 《World Journal of Clinical Cases》 SCIE 2022年第31期11442-11453,共12页
BACKGROUND It remains unclear whether video aids can improve the quality of bystander cardiopulmonary resuscitation(CPR).AIM To summarize simulation-based studies aiming at improving bystander CPR associated with the ... BACKGROUND It remains unclear whether video aids can improve the quality of bystander cardiopulmonary resuscitation(CPR).AIM To summarize simulation-based studies aiming at improving bystander CPR associated with the quality of chest compression and time-related quality parameters.METHODS The systematic review was conducted according to the PRISMA guidelines.All relevant studies were searched through PubMed,EMBASE,Medline and Cochrane Library databases.The risk of bias was evaluated using the Cochrane collaboration tool.RESULTS A total of 259 studies were eligible for inclusion,and 6 randomised controlled trial studies were ultimately included.The results of meta-analysis indicated that video-assisted CPR(V-CPR)was significantly associated with the improved mean chest compression rate[OR=0.66(0.49-0.82),P<0.001],and the proportion of chest compression with correct hand positioning[OR=1.63(0.71-2.55),P<0.001].However,the difference in mean chest compression depth was not statistically significant[OR=0.18(-0.07-0.42),P=0.15],and V-CPR was not associated with the time to first chest compression compared to telecommunicator CPR[OR=-0.12(-0.88-0.63),P=0.75].CONCLUSION Video real-time guidance by the dispatcher can improve the quality of bystander CPR to a certain extent.However,the quality is still not ideal,and there is a lack of guidance caused by poor video signal or inadequate interaction. 展开更多
关键词 Dispatcher-assisted cardiopulmonary resuscitation Video Quality of chest compressions simulated cardiac arrests
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