In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algeb...In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.展开更多
We analyze existence and uniqueness of solutions for perturbations of a Jensen functional inequality in several variables.Applications in connection with asymptotic behaviors of isomorphisms,derivations and n-Jordan d...We analyze existence and uniqueness of solutions for perturbations of a Jensen functional inequality in several variables.Applications in connection with asymptotic behaviors of isomorphisms,derivations and n-Jordan derivations on Banach algebras are also provided.The results of this paper correct and improve the main results of[12,16,22,23]and improve the corresponding results in[2,9,27],but under weaker assumptions.展开更多
Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local ac...Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local actions be a generalized Lie triple higher derivation by local actions satisfying Gn([[x,y],z])=Σ_(i+j+k=n)[[Gi(x),δj(y)],δk(z)]for all x,y,z∈T with xyz=0.Under some mild conditions on T,we prove in this paper that every nonlinear generalized Lie triple higher derivation by local actions on triangular algebras is proper.As an application we shall give a characterization of nonlinear generalized Lie triple higher derivations by local actions on upper triangular matrix algebras and nest algebras,respectively.At the same time,it also improves some interesting conclusions,such as[J.Algebra Appl.22(3),2023,Paper No.2350059],[Axioms,11,2022,1–16].展开更多
Let A be a unital^(*)-algebra containing a nontrivial projection,N be the set of non-negative integers.Under some mild condi-tions on A,it is shown that any nonlinear mixed Jordan triple^(*)-higher derivation D={dn}n...Let A be a unital^(*)-algebra containing a nontrivial projection,N be the set of non-negative integers.Under some mild condi-tions on A,it is shown that any nonlinear mixed Jordan triple^(*)-higher derivation D={dn}n∈N is an additive^(*)-higher derivation.In particu-lar,we apply the above result to prime^(*)-algebras and von Neumann algebras with no central summands of typeⅠ1.展开更多
In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space o...In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space of all isomorphism classes of abelian extensions.Finally,we consider formal deformations of 3-LieHDer pairs that are governed by the cohomology with self-coefficient.展开更多
Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derive...Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derived vesicles(MDVs)are an emerging subpopulation of extracellular vesicle(EV)first discovered in 2008 that allow mitochondria to communicate with their surroundings.展开更多
Ischemic stroke(IS)presents a major threat to human life and health due to its high disability and mortality rates.3-n-Butylphthalide(NBP),derived from celery seeds of the Apiaceae family native to the Mediterranean r...Ischemic stroke(IS)presents a major threat to human life and health due to its high disability and mortality rates.3-n-Butylphthalide(NBP),derived from celery seeds of the Apiaceae family native to the Mediterranean region,was first introduced in China for acute IS treatment in 2004.NBP demonstrates multiple therapeutic actions,including reconstruction of microcirculation in the cerebral ischemia area,inhibition of platelet aggregation,reduction of cerebral infarction volume,maintenance of blood-brain barrier(BBB)integrity,and enhancement of cerebral blood perfusion.However,its overall efficacy remains moderate,limited by poor water solubility and low bioavailability,which constrains its clinical application.To address these limitations,researchers have actively pursued the development of NBP derivatives and analogs,achieving notable progress.These efforts,including substituent introduction,ring opening derivatization,esterification,and atom substitution,have generated diverse NBP derivatives.Several of these derivatives have advanced to clinical studies.Specifically,potassium 2-(1-hydroxypentyl)-benzoate(PHPB),brozopentyl sodium(BZP),and XY-03-EA(ZONK1103)have reached phase II clinical trials,while(S)-2-(1-acetoxypentyl)benzoic acid L-arginine salt(AAPB)has received clinical trial approval for 2024.This review examines the structural modification and optimization of NBP over the past two decades from a medicinal chemistry perspective,aiming to facilitate the development of superior derivatives and advance cerebral ischemia treatment.展开更多
The thermal decomposition characteristic of ammonium perchlorate(AP)represents a critical factor in determining the performance of solid propellants,which has aroused significant interest on the structure and performa...The thermal decomposition characteristic of ammonium perchlorate(AP)represents a critical factor in determining the performance of solid propellants,which has aroused significant interest on the structure and performance improvement of kinds of catalysts.In this study,bimetallic metal-organic frameworks(MOFs),such as CuCo-BTC(BTC=1,3,5-Benzenetricarboxylic acid,H_(3)BTC),CuNi-BTC,and CoNi-BTC,were synthesized by solvothermal(ST)and spray-drying(SD)methods,and then calcined at 400℃for 2 h to form metal oxides.The catalysts as well as their catalytic effects for AP decomposition were characterized by FTIR,XRD,SEM,XPS,TG,DSC,TG-IR,EIS,CV,and LSV.It was found that the rapid coordination of metal ions with ligands during spray drying may lead to catalytic structural defects,promoting the exposure of reactive active sites and increasing the catalytic active region.The results showed that the addition of 2 wt%binary transition metal oxides(BTMOs)as catalysts significantly reduced the high-temperature decomposition(HTD)temperature of AP and enhanced its heat release.Of particular significance is the observation that SD-CoNiO_(x),prepared by spray-drying,reduced the decomposition temperature of AP from 413.26℃(pure AP)to 306℃and enhanced the heat release from 256.79 J/g(pure AP)to 1496.82 J/g,while concomitantly reducing the activation energy by 42%.By analysing the gaseous products during the decomposition of AP+SD-CoNiO_(x)and AP+ST-CoNiO_(x),it was found that SD-CoNiO_(x)could significantly increase the content of high-valent nitrogen oxides during the AP decomposition reaction,which indicates that the BTMOs prepared by spray-drying in the reaction system are more conducive to accelerating the electron transfer in the thermal decomposition process of AP,and can provide a high concentration of reactive oxygen species that oxidize AP to high-valent nitrogen oxide-containing compounds.The present study shows that the structure selectivity of the spray-drying technique influences surfactant molecular arrangement on catalyst surfaces,resulting in their ability to promote higher electron transfer during the catalytic process.Therefore,BTMOs prepared by spray drying method have higher potential for application.展开更多
Two viologen derivatives containing fluorine substituent(F)with an asymmetric structures,1,1'-bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]dihexafluorophosphate(DFPV)and 1-benzyl-1'-(4-(trifluoromethyl)...Two viologen derivatives containing fluorine substituent(F)with an asymmetric structures,1,1'-bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]dihexafluorophosphate(DFPV)and 1-benzyl-1'-(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]di-hexafluorophosphate(Bn-FPV),were synthesized.These viologen derivatives as active materials were used to assemble both flexible and rigid electrochromic devices(ECDs).ECDs based on DFPV exhibited reversible color change from colorless to deep green and ECDs based on Bn-FPV exhibited reversible color change from colorless to blue-green within applied voltage.It was found that the devices based on DFPV showed cycle stability,which could still maintain more than 90% after 1000 cycles.In addition,the modulation rate of the device to the solar irradiance is also calculated to characterize its application potential in smart windows.Among them,the rigid device(R-DFPV)based on the DFPV has a large solar irradiance modulation rate of 54.66%,which has the potential to be used as smart windows.展开更多
Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the q...Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the quality of these medicinal materials and contributing to various health issues.Due to a lack of effective monitoring and imaging tools,the physiological effects of excessive SO_(2) residues in traditional Chinese medicine remain unclear.Therefore,developing a rapid and effective tool for detecting SO_(2) is crucial for understanding its metabolic pathways and effects in vivo.In this study,we developed a near infrared(NIR) and ratiometric fluorescent probe,NIR-RS,which exhibits high sensitivity,selectivity,and rapid response for SO_(2) detection.Notably,NIR-RS accurately quantifies SO_(2) contents in Pinelliae rhizoma(P.rhizoma) samples,with recovery rates from 98.46 % to 102.40 %,and relative standard deviations(RSDs)< 5.0 %.For bioimaging applications,NIR-RS has low cytotoxicity and good mitochondrial-targeting ability,making it suitable for imaging exogenous and endogenous SO_(2) in mitochondria.Additionally,NIR-RS was successfully applied to image SO_(2) content of P.rhizoma samples within cells,revealing that high SO_(2) residue elevated mitochondria adenosine triphosphate(ATP) content,these findings reveal that P.rhizoma with excessive SO_(2) can affect the organism's growth mechanisms through alterations in ATP pathways.In vivo,SO_(2) was found to predominantly accumulate in the liver following gavage with P.rhizoma solution,with accumulation levels increasing in proportion to SO_(2) residue concentration.High SO_(2) concentrations in P.rhizoma can cause pulmonary fibrosis and gastric mucosal damage.This work provides a valuable tool for regulating SO_(2) content in P.rhizoma and may help researcher better understand the metabolism of SO_(2) derivatives and explore their physiological roles in biological systems.展开更多
Mitophagy is a well-characterized and redundant recycling system for damaged mitochondria and a marker of organelle quality(Picca et al.,2023).Yet,the assessment of mitophagy in vivo remains a challenge.The characteri...Mitophagy is a well-characterized and redundant recycling system for damaged mitochondria and a marker of organelle quality(Picca et al.,2023).Yet,the assessment of mitophagy in vivo remains a challenge.The characterization of the endosomallysosomal pathways supporting the endocytic tra fficking has provided invaluable information also into mitophagy signaling.展开更多
Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated ...Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated to neuroinflammation,such as Alzheimer's disease,it is now shown to precede pathological protein aggregations.展开更多
Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level...Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level.However,the recently described multiple cell differentiation dynamics suggest that some bone cells are indeed the progeny of cartilage cells,or chondrocyte-derived osteoblasts.We hypothesized that the cartilage-to-bone phenotype transition is triggered by specific molecular events.First,the process was assessed in mouse bone tissue,and then,it was mimicked using in vivo cell implantation and in vitro serial differentiation protocols.Data indicates that cartilage cells transition to bone cell phenotype during postnatal physiological bone formation.This process can be reproduced using cartilage precursor cells coupled to specific implantation procedures or differentiation protocols.Gene expression profiling reveals that NOTCH,BMP and MAPK signaling pathways are relevant at the phenotype-switch,while the transcription factors Mesp1,Alx1,Grhl3 and Hmx3 are the feasible driver genes for chondrocyte-derived osteoblasts formation.Altogether,this report shows that endochondral ossification can be modeled using primary cell cultures and data indicate that this process is regulated by specific molecular events,previously described at skeleton morphogenesis during embryo development,and from now on also linkable to postnatal bone development and regeneration processes.展开更多
Neurodegenerative disorders represent an increasingly pertinent public health crisis.As a greater proportion of the population ages,neurodegenerative disorders and other diseases of aging place undue burdens on patien...Neurodegenerative disorders represent an increasingly pertinent public health crisis.As a greater proportion of the population ages,neurodegenerative disorders and other diseases of aging place undue burdens on patients,caregivers,and healthcare workers.Alzheimer’s disease(AD)and Parkinson’s disease represent the two most common neurodegenerative disorders in the population,affecting over 65 million people,worldwide.展开更多
Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells en...Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.展开更多
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
Through analyzing problems exist in the conceptual planning of Jiuzhouwa Eco-Wetland Park, the derivation process and approach of its core concepts were discussed.
Let F be a field and char F = p > 3. In this paper the derivation algebras of Lie superalgebras W and S of Cartan-type over F are determined by the calculating method.
To determine the optimal or near optimal parameters of PID controller with incomplete derivation, a novel design method based on differential evolution （DE） algorithm is presented. The controller is called DE-PID co...To determine the optimal or near optimal parameters of PID controller with incomplete derivation, a novel design method based on differential evolution （DE） algorithm is presented. The controller is called DE-PID controller. To overcome the disadvantages of the integral performance criteria in the frequency domain such as IAE, ISE, and ITSE, a new performance criterion in the time domain is proposed. The optimization procedures employing the DE algorithm to search the optimal or near optimal PID controller parameters of a control system are demonstrated in detail. Three typical control systems are chosen to test and evaluate the adaptation and robustness of the proposed DE-PID controller. The simulation results show that the proposed approach has superior features of easy implementation, stable convergence characteristic, and good computational efficiency. Compared with the ZN, GA, and ASA, the proposed design method is indeed more efficient and robust in improving the step response of a control system.展开更多
Induced pluripotent stem （iPS） cells can be derived from human somatic cells by cellular reprograrnming. This technology provides a potential source of non-controversial therapeutic ceils for tissue repair, drug dis...Induced pluripotent stem （iPS） cells can be derived from human somatic cells by cellular reprograrnming. This technology provides a potential source of non-controversial therapeutic ceils for tissue repair, drug discovery, and opportunities for studying the molecular basis of human disease. Normally, mouse embryonic fibroblasts （MEFs） are used as feeder layers in the initial derivation of iPS lines. The pur- pose of this study was to determine whether SNL fibrohlasts can be used to support the growth of human iPS cells reprogrammed from somatic cells using lentiviral expressed reprogramming factors. In our study, iPS cells expressed common pluripotency markers, dis- played human embryonic stem cells （hESCs） morphology and unmethylated promoters of NANOG and OCT4. These data demonstrate that SNL feeder cells can support the derivation and maintenance of human iPS cells.展开更多
基金Supported by Basic Research Foundation of Yunnan Education Department(Nos.2020J0748,2021J0635)Talent Project Foundation of Yunnan Provincial Science and Technology Department(No.202105AC160089)NSF of Yunnan Province(No.202101BA070001198).
文摘In this paper,we investigate the problem of describing the form of Jordan triple derivations on trivial extension algebras.We show that every Jordan triple derivation on a 2-torsion free *-type trivial extension algebra is a sum of a derivation and an antiderivation.As its applications,Jordan triple derivations on triangular algebras are characterized.
文摘We analyze existence and uniqueness of solutions for perturbations of a Jensen functional inequality in several variables.Applications in connection with asymptotic behaviors of isomorphisms,derivations and n-Jordan derivations on Banach algebras are also provided.The results of this paper correct and improve the main results of[12,16,22,23]and improve the corresponding results in[2,9,27],but under weaker assumptions.
基金Supported by Open Research Fund of Hubei Key Laboratory of Mathematical Sciences(Central China Normal University)the Natural Science Foundation of Anhui Province(Grant No.2008085QA01)the University Natural Science Research Project of Anhui Province(Grant No.KJ2019A0107)。
文摘Let R be a commutative ring with unity and T be a triangular algebra over R.Let a sequence G={G_n}_(n∈N)of nonlinear mappings G_n:T→T associated with nonlinear Lie triple higher derivations∆={δ_n}_(n∈N)by local actions be a generalized Lie triple higher derivation by local actions satisfying Gn([[x,y],z])=Σ_(i+j+k=n)[[Gi(x),δj(y)],δk(z)]for all x,y,z∈T with xyz=0.Under some mild conditions on T,we prove in this paper that every nonlinear generalized Lie triple higher derivation by local actions on triangular algebras is proper.As an application we shall give a characterization of nonlinear generalized Lie triple higher derivations by local actions on upper triangular matrix algebras and nest algebras,respectively.At the same time,it also improves some interesting conclusions,such as[J.Algebra Appl.22(3),2023,Paper No.2350059],[Axioms,11,2022,1–16].
基金Supported by the National Natural Science Foundation of China(12271323)。
文摘Let A be a unital^(*)-algebra containing a nontrivial projection,N be the set of non-negative integers.Under some mild condi-tions on A,it is shown that any nonlinear mixed Jordan triple^(*)-higher derivation D={dn}n∈N is an additive^(*)-higher derivation.In particu-lar,we apply the above result to prime^(*)-algebras and von Neumann algebras with no central summands of typeⅠ1.
基金Supported by the National Natural Science Foundation of China(Grant No.12161013)the Basic Research Program(Natural Science)of Guizhou Province(Grant No.ZK[2023]025).
文摘In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space of all isomorphism classes of abelian extensions.Finally,we consider formal deformations of 3-LieHDer pairs that are governed by the cohomology with self-coefficient.
基金supported by project Emerging Infectious Diseases One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases,INF-ACT,Spoke 1 and Spoke 5,Project number PE00000007,CUP B53C20040570005(to PP and DN).
文摘Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derived vesicles(MDVs)are an emerging subpopulation of extracellular vesicle(EV)first discovered in 2008 that allow mitochondria to communicate with their surroundings.
基金supported by the National Natural Science Foundation of China(Nos.21977058 and 82473840)the Key R&D Program of Jiangsu Province(No.BE2021677)+2 种基金China Postdoctoral Science Foundation(No.2018T110533)the Key Natural Science Foundation of Jiangsu Higher Education Institutions(No.20KJA350002)Jiangsu Province Innovation Project of Postgraduate Training(No.KYCX22_3380).
文摘Ischemic stroke(IS)presents a major threat to human life and health due to its high disability and mortality rates.3-n-Butylphthalide(NBP),derived from celery seeds of the Apiaceae family native to the Mediterranean region,was first introduced in China for acute IS treatment in 2004.NBP demonstrates multiple therapeutic actions,including reconstruction of microcirculation in the cerebral ischemia area,inhibition of platelet aggregation,reduction of cerebral infarction volume,maintenance of blood-brain barrier(BBB)integrity,and enhancement of cerebral blood perfusion.However,its overall efficacy remains moderate,limited by poor water solubility and low bioavailability,which constrains its clinical application.To address these limitations,researchers have actively pursued the development of NBP derivatives and analogs,achieving notable progress.These efforts,including substituent introduction,ring opening derivatization,esterification,and atom substitution,have generated diverse NBP derivatives.Several of these derivatives have advanced to clinical studies.Specifically,potassium 2-(1-hydroxypentyl)-benzoate(PHPB),brozopentyl sodium(BZP),and XY-03-EA(ZONK1103)have reached phase II clinical trials,while(S)-2-(1-acetoxypentyl)benzoic acid L-arginine salt(AAPB)has received clinical trial approval for 2024.This review examines the structural modification and optimization of NBP over the past two decades from a medicinal chemistry perspective,aiming to facilitate the development of superior derivatives and advance cerebral ischemia treatment.
基金supported by the National Natural ScienceFoundation of China(Grant No.52203332)。
文摘The thermal decomposition characteristic of ammonium perchlorate(AP)represents a critical factor in determining the performance of solid propellants,which has aroused significant interest on the structure and performance improvement of kinds of catalysts.In this study,bimetallic metal-organic frameworks(MOFs),such as CuCo-BTC(BTC=1,3,5-Benzenetricarboxylic acid,H_(3)BTC),CuNi-BTC,and CoNi-BTC,were synthesized by solvothermal(ST)and spray-drying(SD)methods,and then calcined at 400℃for 2 h to form metal oxides.The catalysts as well as their catalytic effects for AP decomposition were characterized by FTIR,XRD,SEM,XPS,TG,DSC,TG-IR,EIS,CV,and LSV.It was found that the rapid coordination of metal ions with ligands during spray drying may lead to catalytic structural defects,promoting the exposure of reactive active sites and increasing the catalytic active region.The results showed that the addition of 2 wt%binary transition metal oxides(BTMOs)as catalysts significantly reduced the high-temperature decomposition(HTD)temperature of AP and enhanced its heat release.Of particular significance is the observation that SD-CoNiO_(x),prepared by spray-drying,reduced the decomposition temperature of AP from 413.26℃(pure AP)to 306℃and enhanced the heat release from 256.79 J/g(pure AP)to 1496.82 J/g,while concomitantly reducing the activation energy by 42%.By analysing the gaseous products during the decomposition of AP+SD-CoNiO_(x)and AP+ST-CoNiO_(x),it was found that SD-CoNiO_(x)could significantly increase the content of high-valent nitrogen oxides during the AP decomposition reaction,which indicates that the BTMOs prepared by spray-drying in the reaction system are more conducive to accelerating the electron transfer in the thermal decomposition process of AP,and can provide a high concentration of reactive oxygen species that oxidize AP to high-valent nitrogen oxide-containing compounds.The present study shows that the structure selectivity of the spray-drying technique influences surfactant molecular arrangement on catalyst surfaces,resulting in their ability to promote higher electron transfer during the catalytic process.Therefore,BTMOs prepared by spray drying method have higher potential for application.
基金Funded by the Natural Science Foundation of Guangdong(Nos.2014A030313241,2014B090901068,and 2016A010103003)。
文摘Two viologen derivatives containing fluorine substituent(F)with an asymmetric structures,1,1'-bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]dihexafluorophosphate(DFPV)and 1-benzyl-1'-(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]di-hexafluorophosphate(Bn-FPV),were synthesized.These viologen derivatives as active materials were used to assemble both flexible and rigid electrochromic devices(ECDs).ECDs based on DFPV exhibited reversible color change from colorless to deep green and ECDs based on Bn-FPV exhibited reversible color change from colorless to blue-green within applied voltage.It was found that the devices based on DFPV showed cycle stability,which could still maintain more than 90% after 1000 cycles.In addition,the modulation rate of the device to the solar irradiance is also calculated to characterize its application potential in smart windows.Among them,the rigid device(R-DFPV)based on the DFPV has a large solar irradiance modulation rate of 54.66%,which has the potential to be used as smart windows.
基金supported by the Natural Science Foundation of Hubei Province (Nos.2023AFB376 and 2024AFD287)National Key Research and Development Program (No.2023YFC3503804)the National Natural Science Foundation of China (No.22077044)。
文摘Sulfur dioxide(SO_(2)) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the quality of these medicinal materials and contributing to various health issues.Due to a lack of effective monitoring and imaging tools,the physiological effects of excessive SO_(2) residues in traditional Chinese medicine remain unclear.Therefore,developing a rapid and effective tool for detecting SO_(2) is crucial for understanding its metabolic pathways and effects in vivo.In this study,we developed a near infrared(NIR) and ratiometric fluorescent probe,NIR-RS,which exhibits high sensitivity,selectivity,and rapid response for SO_(2) detection.Notably,NIR-RS accurately quantifies SO_(2) contents in Pinelliae rhizoma(P.rhizoma) samples,with recovery rates from 98.46 % to 102.40 %,and relative standard deviations(RSDs)< 5.0 %.For bioimaging applications,NIR-RS has low cytotoxicity and good mitochondrial-targeting ability,making it suitable for imaging exogenous and endogenous SO_(2) in mitochondria.Additionally,NIR-RS was successfully applied to image SO_(2) content of P.rhizoma samples within cells,revealing that high SO_(2) residue elevated mitochondria adenosine triphosphate(ATP) content,these findings reveal that P.rhizoma with excessive SO_(2) can affect the organism's growth mechanisms through alterations in ATP pathways.In vivo,SO_(2) was found to predominantly accumulate in the liver following gavage with P.rhizoma solution,with accumulation levels increasing in proportion to SO_(2) residue concentration.High SO_(2) concentrations in P.rhizoma can cause pulmonary fibrosis and gastric mucosal damage.This work provides a valuable tool for regulating SO_(2) content in P.rhizoma and may help researcher better understand the metabolism of SO_(2) derivatives and explore their physiological roles in biological systems.
文摘Mitophagy is a well-characterized and redundant recycling system for damaged mitochondria and a marker of organelle quality(Picca et al.,2023).Yet,the assessment of mitophagy in vivo remains a challenge.The characterization of the endosomallysosomal pathways supporting the endocytic tra fficking has provided invaluable information also into mitophagy signaling.
基金supported by FWO(Fonds voor Wetenschappelijk Onderzoek),grant number G07562NFWO(to BB)。
文摘Neuroinflammation is a key process in the pathogenesis of various neurodegenerative diseases,such as multiple sclerosis(MS),Alzheimer's disease,and traumatic brain injury.Even for disorders historically unrelated to neuroinflammation,such as Alzheimer's disease,it is now shown to precede pathological protein aggregations.
基金funded by Grants PID2021-127191OB-I00,RTI2018-101708-A-I00,PRE2018-084542 and PRE2022-102680 funded by MCIN/AEI/10.13039/501100011033 and by“ERDF A way of making Europe”Grant RYC2018-025502-I is funded by MCIN/AEI/10.13039/501100011033 and by“ESF Investing in your future”+1 种基金Grant MDM-20170720 Maria de Maeztu Units of Excellence Program funded by the Spanish State Research Agencysupported by Instituto de Salud CarlosⅢ,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATA-MP)。
文摘Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues.Classically,cartilage and bone formation have been considered independent processes at cellular level.However,the recently described multiple cell differentiation dynamics suggest that some bone cells are indeed the progeny of cartilage cells,or chondrocyte-derived osteoblasts.We hypothesized that the cartilage-to-bone phenotype transition is triggered by specific molecular events.First,the process was assessed in mouse bone tissue,and then,it was mimicked using in vivo cell implantation and in vitro serial differentiation protocols.Data indicates that cartilage cells transition to bone cell phenotype during postnatal physiological bone formation.This process can be reproduced using cartilage precursor cells coupled to specific implantation procedures or differentiation protocols.Gene expression profiling reveals that NOTCH,BMP and MAPK signaling pathways are relevant at the phenotype-switch,while the transcription factors Mesp1,Alx1,Grhl3 and Hmx3 are the feasible driver genes for chondrocyte-derived osteoblasts formation.Altogether,this report shows that endochondral ossification can be modeled using primary cell cultures and data indicate that this process is regulated by specific molecular events,previously described at skeleton morphogenesis during embryo development,and from now on also linkable to postnatal bone development and regeneration processes.
基金supported by the Canadian Institutes of Health Research(DFD-181599)the National Institutes of Health(T32AG058527)to RJB and R0190106435 to VM.
文摘Neurodegenerative disorders represent an increasingly pertinent public health crisis.As a greater proportion of the population ages,neurodegenerative disorders and other diseases of aging place undue burdens on patients,caregivers,and healthcare workers.Alzheimer’s disease(AD)and Parkinson’s disease represent the two most common neurodegenerative disorders in the population,affecting over 65 million people,worldwide.
基金supported by the National Natural Science Foundation of China,No.32171356(to YW)Self-Support Research Projects of Shihezi University,No.ZZZC2021105(to WJ)+1 种基金Capital Medical University Natural Science Cultivation Fund,No.PYZ23044(to FQM)Beijing Municipal Natural Science Foundation,No.7244410(to JHD)。
文摘Previous research has demonstrated the feasibility of repairing nerve defects through acellular allogeneic nerve grafting with bone marrow mesenchymal stem cells.However,adult tissue–derived mesenchymal stem cells encounter various obstacles,including limited tissue sources,invasive acquisition methods,cellular heterogeneity,purification challenges,cellular senescence,and diminished pluripotency and proliferation over successive passages.In this study,we used induced pluripotent stem cell-derived mesenchymal stem cells,known for their self-renewal capacity,multilineage differentiation potential,and immunomodulatory characteristics.We used induced pluripotent stem cell-derived mesenchymal stem cells in conjunction with acellular nerve allografts to address a 10 mm-long defect in a rat model of sciatic nerve injury.Our findings reveal that induced pluripotent stem cell-derived mesenchymal stem cells exhibit survival for up to 17 days in a rat model of peripheral nerve injury with acellular nerve allograft transplantation.Furthermore,the combination of acellular nerve allograft and induced pluripotent stem cell-derived mesenchymal stem cells significantly accelerates the regeneration of injured axons and improves behavioral function recovery in rats.Additionally,our in vivo and in vitro experiments indicate that induced pluripotent stem cell-derived mesenchymal stem cells play a pivotal role in promoting neovascularization.Collectively,our results suggest the potential of acellular nerve allografts with induced pluripotent stem cell-derived mesenchymal stem cells to augment nerve regeneration in rats,offering promising therapeutic strategies for clinical translation.
文摘Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
文摘Through analyzing problems exist in the conceptual planning of Jiuzhouwa Eco-Wetland Park, the derivation process and approach of its core concepts were discussed.
文摘Let F be a field and char F = p > 3. In this paper the derivation algebras of Lie superalgebras W and S of Cartan-type over F are determined by the calculating method.
基金the National Natural Science Foundation of China (60375001)the Scientific Research Foundation of Hunan Provincial Education Department (05B016).
文摘To determine the optimal or near optimal parameters of PID controller with incomplete derivation, a novel design method based on differential evolution （DE） algorithm is presented. The controller is called DE-PID controller. To overcome the disadvantages of the integral performance criteria in the frequency domain such as IAE, ISE, and ITSE, a new performance criterion in the time domain is proposed. The optimization procedures employing the DE algorithm to search the optimal or near optimal PID controller parameters of a control system are demonstrated in detail. Three typical control systems are chosen to test and evaluate the adaptation and robustness of the proposed DE-PID controller. The simulation results show that the proposed approach has superior features of easy implementation, stable convergence characteristic, and good computational efficiency. Compared with the ZN, GA, and ASA, the proposed design method is indeed more efficient and robust in improving the step response of a control system.
基金supported by the National Institute of Health,USA (No.R21 RR025408)
文摘Induced pluripotent stem （iPS） cells can be derived from human somatic cells by cellular reprograrnming. This technology provides a potential source of non-controversial therapeutic ceils for tissue repair, drug discovery, and opportunities for studying the molecular basis of human disease. Normally, mouse embryonic fibroblasts （MEFs） are used as feeder layers in the initial derivation of iPS lines. The pur- pose of this study was to determine whether SNL fibrohlasts can be used to support the growth of human iPS cells reprogrammed from somatic cells using lentiviral expressed reprogramming factors. In our study, iPS cells expressed common pluripotency markers, dis- played human embryonic stem cells （hESCs） morphology and unmethylated promoters of NANOG and OCT4. These data demonstrate that SNL feeder cells can support the derivation and maintenance of human iPS cells.
