This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real sto...This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real stock price after discounting inflation.Then,under the constraint of external guarantee of DC pension terminal wealth,self-protection is introduced to study the maximization of the expected utility of terminal wealth at retirement time and any time before retirement.The explicit solution of the optimal investment strategy of DC pension at retirement time and any time before retirement should be derived by martingale method.Finally,the influence of selfprotection on the optimal investment strategy of DC pension is numerically analyzed.展开更多
Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection ag...Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.展开更多
Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficie...Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy.Herein, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.展开更多
We present a conceptual configuration of a high-temperature superconducting（HTS）magnet made from REBCO（Re=Rare Earth,B=Barium,C=Copper,O=Oxide）annular plates,called a Bitter-like HTS magnet,which can operate in pe...We present a conceptual configuration of a high-temperature superconducting（HTS）magnet made from REBCO（Re=Rare Earth,B=Barium,C=Copper,O=Oxide）annular plates,called a Bitter-like HTS magnet,which can operate in persistent current mode without joint resistance and can be excited by a flux pump and without current leads and a persistent power supply.An REBCO annular magnet which can generate 1.5 T corresponding to the operating current density 80%of critical current density of the magnet at an operating temperature of65 K is conceptually designed.Then the thermal stability of the magnet is numerically simulated by Comsol software.Whein a piece of RBCO annular plate quenches,the maximum released energy is its stored energy because each REBCO annular plate in the Bitter-like magnet is in parallel.To calculate the stored energy in the REBCO annular plate,the inductance of every annular plate,including self-inductance and mutual inductance,is calculated.Compared with the minimum quench energy（MQE）and stored energy in one REBCO annular plate,the stored energy in one REBCO annular plate is always smaller than the MQE,and the REBCO annular plate will not be damaged even though the stored energy in the REBCO annular plate is fully released,which indicates that this 1.5 T Bitter-like magnet has the property of self-protection.展开更多
Constructing self-protected metastable intermolecular composites(MICs) enables the regulation of microstructures towards boosting controllable detonation performance,and also prevents information leakage,which is mean...Constructing self-protected metastable intermolecular composites(MICs) enables the regulation of microstructures towards boosting controllable detonation performance,and also prevents information leakage,which is meaningful but challenging.Herein,a convenient and efficient method of combining highly-controlled electrophoretic assembly,surface modification and microwave heat treatment was employed to design promising heattriggered wettability switchable high-energy smart C-doped Al/Cr_(2)O_(3)MIC,and surface modification mechanism was proposed,respectively.The anti-wetting ability of the product was demonstrated by a series of tests of water contact angle,impact resistance,immersion,selfcleaning,etc.The key information recording/encryption procedures were realized by constructing a hydrophilic/hydrophobic interface and adjusting the wettability of the product.In addition,the output heat of asobtained smart MIC can reach ~1.5 kJ·g^(-1),and its attenuation rate was only ~30% even after underwater aging,further verifying its potential practicality.Thus,our design provides a promising strategy for engineering smart MIC with diversified functional structures for blasting applications and beyond.展开更多
Objective： To understand the situation of nursing students was stabbed by sharp instrument,in order to provide a scientific basis to take protective measures.Method：By using a self-designed questionnaire.The 100 nur...Objective： To understand the situation of nursing students was stabbed by sharp instrument,in order to provide a scientific basis to take protective measures.Method：By using a self-designed questionnaire.The 100 nursing students were randomly selected from a hospital for retrospective investigation.There are 98 valid data.Results： The data shows that sharp instrument injury is more common in nursing students. Nursing students＇ protection consciousness is low, and protective ability is poor.Conclusion： Nursing students awareness of self- protection to sharp instrument injury is not enough,in order to avoid the risk of infection of nursing students occupation.When they entered the clinics, practice of systematic pre occupation safety education is very necessary;and the school and the hospital should actively implement the management standardized operation regulations;and put up student occupation injury management regulations;to improve the safety performance of nursing equipment.展开更多
Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation ...Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation is got to reinforce the muzzle shunt rail gun rail. The preliminary friction and abrasion test results show that the formulation is acceptable and the abrasion resistance of the steel rail enhances to some extent after the surface reinforcement.展开更多
Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In th...Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In this work,a novel method,namely hydriding combustion synthesis plus short-term mechanical milling followed by air exposure,was proposed to synthesize air stable and autocatalytic magnesium nickel hydride(Mg2NiH4),which shows excellent hydrogen absorption/desorption kinetics,capacity retention and oxidation resistance.The short-term-milled Mg2NiH4 can desorb 2.97 wt.%hydrogen within 500 s at 230℃.Even after exposure under air atmosphere for 67 days,it can still desorb 2.88 wt.%hydrogen within 500 s at 230℃.The experimental and theoretical results both indicated that the surface of as-milled Mg2NiH4 was easy to be oxidized under air atmosphere.However,the in-situ formed Ni during air exposure of Mg2NiH4 improved the hydrogen desorption kinetics,and the formed surface passivation layer maintained the hydrogen storage capacity and avoided further poisoning,which we called autocatalytic and self-protective effect.Such a novel dual effect modified the reaction activity and oxidation resistance of the air-exposed Mg2NiH4.Our findings provide useful insights into the design and preparation of air stable metal-based hydride for large-scale utilization and long-term storage.展开更多
Shape memory alloys (SMA) have been applied to a wide variety of applications in a number of different fields such as aeronautical applications, sensors/actuators, medical sciences as well as orthodontics. It is a hot...Shape memory alloys (SMA) have been applied to a wide variety of applications in a number of different fields such as aeronautical applications, sensors/actuators, medical sciences as well as orthodontics. It is a hot topic to enhance the anti-corrosion ability of orthodontic wires for clinical applications. In this letter, a very nice fractal structure, micro-domains with identical nanometer sized grooves, was ob- tained on the surfaces of the orthodontic wires with an oxygen plasma and acid corrosion. The concave parts of the grooves were dominated by titanium and convex parts were the same as the bulk wires. The micro-nano fractal structure generated a hydrophobic surface with the largest contact angle to water being about 157°. The titanium dominated nanolayer and the hydrophobicity of the surface resulted in jointly the great improvement of the anti-corrosion ability of the orthodontic wires. Because the fractal structures of the wires were formed automatically when they immersed in acidic environment, hence, the self-protection of the oxygen plasma-treated orthodontic wires in acidic environment indicates their potential applications in orthodontics, and should be also inspirable for other applications of SMA materials.展开更多
基金Supported by the National Social Science Foundation of China(20BTJ048)Anhui University Humanities and Social Science Research Major Project(SK2021ZD0043)。
文摘This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real stock price after discounting inflation.Then,under the constraint of external guarantee of DC pension terminal wealth,self-protection is introduced to study the maximization of the expected utility of terminal wealth at retirement time and any time before retirement.The explicit solution of the optimal investment strategy of DC pension at retirement time and any time before retirement should be derived by martingale method.Finally,the influence of selfprotection on the optimal investment strategy of DC pension is numerically analyzed.
文摘Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.
基金supported by the National Natural Science Foundation of China (Nos. 82073807 and 81973277)the WorldClass Universities (Disciplines)the Characteristic Development Guidance Funds for the Central Universities,China (No. PY3A012)。
文摘Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy.Herein, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.
基金Supported by the Fundamental Research Funds for the Central Universities under Grant No 2018MS004
文摘We present a conceptual configuration of a high-temperature superconducting（HTS）magnet made from REBCO（Re=Rare Earth,B=Barium,C=Copper,O=Oxide）annular plates,called a Bitter-like HTS magnet,which can operate in persistent current mode without joint resistance and can be excited by a flux pump and without current leads and a persistent power supply.An REBCO annular magnet which can generate 1.5 T corresponding to the operating current density 80%of critical current density of the magnet at an operating temperature of65 K is conceptually designed.Then the thermal stability of the magnet is numerically simulated by Comsol software.Whein a piece of RBCO annular plate quenches,the maximum released energy is its stored energy because each REBCO annular plate in the Bitter-like magnet is in parallel.To calculate the stored energy in the REBCO annular plate,the inductance of every annular plate,including self-inductance and mutual inductance,is calculated.Compared with the minimum quench energy（MQE）and stored energy in one REBCO annular plate,the stored energy in one REBCO annular plate is always smaller than the MQE,and the REBCO annular plate will not be damaged even though the stored energy in the REBCO annular plate is fully released,which indicates that this 1.5 T Bitter-like magnet has the property of self-protection.
基金financially supported by the National Natural Science Foundation of China (Nos.21805014,82102635,52373087,52003300 and 22109120)Chongqing Municipal Education Commission (Nos.CXQT20026 and KJQN202201408)。
文摘Constructing self-protected metastable intermolecular composites(MICs) enables the regulation of microstructures towards boosting controllable detonation performance,and also prevents information leakage,which is meaningful but challenging.Herein,a convenient and efficient method of combining highly-controlled electrophoretic assembly,surface modification and microwave heat treatment was employed to design promising heattriggered wettability switchable high-energy smart C-doped Al/Cr_(2)O_(3)MIC,and surface modification mechanism was proposed,respectively.The anti-wetting ability of the product was demonstrated by a series of tests of water contact angle,impact resistance,immersion,selfcleaning,etc.The key information recording/encryption procedures were realized by constructing a hydrophilic/hydrophobic interface and adjusting the wettability of the product.In addition,the output heat of asobtained smart MIC can reach ~1.5 kJ·g^(-1),and its attenuation rate was only ~30% even after underwater aging,further verifying its potential practicality.Thus,our design provides a promising strategy for engineering smart MIC with diversified functional structures for blasting applications and beyond.
文摘Objective： To understand the situation of nursing students was stabbed by sharp instrument,in order to provide a scientific basis to take protective measures.Method：By using a self-designed questionnaire.The 100 nursing students were randomly selected from a hospital for retrospective investigation.There are 98 valid data.Results： The data shows that sharp instrument injury is more common in nursing students. Nursing students＇ protection consciousness is low, and protective ability is poor.Conclusion： Nursing students awareness of self- protection to sharp instrument injury is not enough,in order to avoid the risk of infection of nursing students occupation.When they entered the clinics, practice of systematic pre occupation safety education is very necessary;and the school and the hospital should actively implement the management standardized operation regulations;and put up student occupation injury management regulations;to improve the safety performance of nursing equipment.
文摘Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation is got to reinforce the muzzle shunt rail gun rail. The preliminary friction and abrasion test results show that the formulation is acceptable and the abrasion resistance of the steel rail enhances to some extent after the surface reinforcement.
基金the National Natural Science Foundation of China(Nos.51771092,52071177,and 21975125)Six Talent Peaks Project in Jiangsu Province(No.2018-XNY-020)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In this work,a novel method,namely hydriding combustion synthesis plus short-term mechanical milling followed by air exposure,was proposed to synthesize air stable and autocatalytic magnesium nickel hydride(Mg2NiH4),which shows excellent hydrogen absorption/desorption kinetics,capacity retention and oxidation resistance.The short-term-milled Mg2NiH4 can desorb 2.97 wt.%hydrogen within 500 s at 230℃.Even after exposure under air atmosphere for 67 days,it can still desorb 2.88 wt.%hydrogen within 500 s at 230℃.The experimental and theoretical results both indicated that the surface of as-milled Mg2NiH4 was easy to be oxidized under air atmosphere.However,the in-situ formed Ni during air exposure of Mg2NiH4 improved the hydrogen desorption kinetics,and the formed surface passivation layer maintained the hydrogen storage capacity and avoided further poisoning,which we called autocatalytic and self-protective effect.Such a novel dual effect modified the reaction activity and oxidation resistance of the air-exposed Mg2NiH4.Our findings provide useful insights into the design and preparation of air stable metal-based hydride for large-scale utilization and long-term storage.
基金Supported by the National Natural Science Foundation of China (Grant No. 30572067)Ministry of Science and Technology of China
文摘Shape memory alloys (SMA) have been applied to a wide variety of applications in a number of different fields such as aeronautical applications, sensors/actuators, medical sciences as well as orthodontics. It is a hot topic to enhance the anti-corrosion ability of orthodontic wires for clinical applications. In this letter, a very nice fractal structure, micro-domains with identical nanometer sized grooves, was ob- tained on the surfaces of the orthodontic wires with an oxygen plasma and acid corrosion. The concave parts of the grooves were dominated by titanium and convex parts were the same as the bulk wires. The micro-nano fractal structure generated a hydrophobic surface with the largest contact angle to water being about 157°. The titanium dominated nanolayer and the hydrophobicity of the surface resulted in jointly the great improvement of the anti-corrosion ability of the orthodontic wires. Because the fractal structures of the wires were formed automatically when they immersed in acidic environment, hence, the self-protection of the oxygen plasma-treated orthodontic wires in acidic environment indicates their potential applications in orthodontics, and should be also inspirable for other applications of SMA materials.
