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Digitally-Assisted Analog Self-Interference Cancellation for STAR System
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作者 Pan Wensheng Shi Chengzhe +2 位作者 Li Tong Shen Ying Shao Shihai 《China Communications》 2025年第3期36-53,共18页
To enable simultaneous transmit and receive(STAR)on the same frequency in a densely deployed space with multi-interference sources,this work proposes a digitally-assisted analog selfinterference cancellation method,wh... To enable simultaneous transmit and receive(STAR)on the same frequency in a densely deployed space with multi-interference sources,this work proposes a digitally-assisted analog selfinterference cancellation method,which can acquire reference signals through flexible wired/wireless switching access.Based on this method,the Minimum Mean Square Error algorithm with known channel state information is derived in detail,determining the upper limit of the cancellation performance,and the Adaptive Dithered Linear Search algorithm for real-time engineering cancellation is given.The correctness of theoretical analysis is verified by the practical self-interference channel measured by a vector network analyzer.Furthermore,we have designed and implemented the corresponding multiinterference cancellation prototype with the digitallyassisted structure,capable of handling multiple interferences(up to three)and supporting a large receive bandwidth of 100 MHz as well as a wide frequency coverage from 30 MHz to 3000 MHz.Prototype test results demonstrate that in the presence of three interferences,when the single interference bandwidth is 0.2/2/20 MHz(corresponding to the receive bandwidth of 2/20/100 MHz),the cancellation performance can reach 46/32/22 dB or more. 展开更多
关键词 analog self-interference cancellation channel measurement digitally-assisted multiinterference prototype design simultaneous transmit and receive
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Variable Projection Order Adaptive Filtering Algorithm for Self-interference Cancellation in Airborne Radars
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作者 LI Haorui GAO Ying +1 位作者 GUO Xinyu OU Shifeng 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第4期497-508,共12页
The adaptive filtering algorithm with a fixed projection order is unable to adjust its performance in response to changes in the external environment of airborne radars.To overcome this limitation,a new approach is in... The adaptive filtering algorithm with a fixed projection order is unable to adjust its performance in response to changes in the external environment of airborne radars.To overcome this limitation,a new approach is introduced,which is the variable projection order Ekblom norm-promoted adaptive algorithm(VPO-EPAA).The method begins by examining the mean squared deviation(MSD)of the EPAA,deriving a formula for its MSD.Next,it compares the MSD of EPAA at two different projection orders and selects the one that minimizes the MSD as the parameter for the current iteration.Furthermore,the algorithm’s computational complexity is analyzed theoretically.Simulation results from system identification and self-interference cancellation show that the proposed algorithm performs exceptionally well in airborne radar signal self-interference cancellation,even under various noise intensities and types of interference. 展开更多
关键词 adaptive filtering algorithm airborne radar variable projection order mean squared deviation self-interference cancellation
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SFN促进非小细胞性肺癌恶性进展的作用研究
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作者 许弘坤 王恩琴 +1 位作者 金虹燕 张丽红 《浙江实用医学》 2025年第2期102-108,共7页
目的探讨SFN在非小细胞性肺癌(NSCLC)恶性进展中的作用。方法siRNA干扰PC-9细胞SFN表达,分别利用平板克隆实验、Transwell实验、流式细胞术检测SFN对肺癌细胞增殖、迁移、侵袭和凋亡的作用;采用生物信息学数据库和免疫组化分析SFN与BAD... 目的探讨SFN在非小细胞性肺癌(NSCLC)恶性进展中的作用。方法siRNA干扰PC-9细胞SFN表达,分别利用平板克隆实验、Transwell实验、流式细胞术检测SFN对肺癌细胞增殖、迁移、侵袭和凋亡的作用;采用生物信息学数据库和免疫组化分析SFN与BAD在NSCLC组织中的表达水平及相关性。结果(1)体外功能实验显示,干扰SFN表达后NSCLC细胞的增殖、侵袭和迁移能力均受到抑制,而凋亡能力增强;(2)生物信息分析显示,SFN与BAD在NSCLC组织中的蛋白表达水平显著高于正常肺组织,且在NSCLC中,SFN与BAD的表达呈正相关;(3)免疫组化结果提示,在NSCLC组织中SFN和BAD的表达呈正相关。结论SFN具有促进NSCLC增殖、迁移、侵袭和减弱凋亡的作用,提示SFN与NSCLC的恶性进展密切相关;SFN和BAD可能存在共表达作用并参与NSCLC的发生发展。 展开更多
关键词 非小细胞性肺癌 sfn BAD 恶性进展
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数字电视发射机同步误差对SFN性能影响及其抑制策略
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作者 林胜威 《电视技术》 2025年第7期152-154,共3页
单频网(Single Frequency Network,SFN)的运行对发射机的同步提出极高的技术要求,任何同步误差都可能对网络性能产生不利影响。首先分析SFN中时间、频率和相位同步误差的定义与分类,其次探讨其对关键性能指标的影响机理,并量化同步误差... 单频网(Single Frequency Network,SFN)的运行对发射机的同步提出极高的技术要求,任何同步误差都可能对网络性能产生不利影响。首先分析SFN中时间、频率和相位同步误差的定义与分类,其次探讨其对关键性能指标的影响机理,并量化同步误差对覆盖范围和信道容量的削弱程度,最后针对同步误差的成因提出提高授时源精度、优化参考时钟选型、改进同步跟踪环路设计及多径信号抑制等策略。 展开更多
关键词 数字电视 单频网(sfn) 同步误差 干扰抑制
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On the Performance of Active Analog Self-Interference Cancellation Techniques for Beyond 5G Systems 被引量:5
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作者 Haifeng Luo Mark Holm Tharmalingam Ratnarajah 《China Communications》 SCIE CSCD 2021年第10期158-168,共11页
The in-band full-duplex(IBFD)mechanism is of interest in beyond 5 G systems due to its potential to enhance spectral efficiency and reduce delay.To achieve the maximum gain of IBFD systems,the significant self-interfe... The in-band full-duplex(IBFD)mechanism is of interest in beyond 5 G systems due to its potential to enhance spectral efficiency and reduce delay.To achieve the maximum gain of IBFD systems,the significant self-interference(SI)must be efficiently suppressed.The challenges of wideband selfinterference cancellation(SIC)lie in the radio frequency(RF)domain,where the performance will be limited by the hardware.This paper reviews current RF cancellation mechanisms and investigates an efficient mechanism for future wideband systems with minimum complexity.The working principle and implementation details of multi-tap cancellers are first introduced,then an optical domain-based RF canceller is reviewed,and a novel low-cost design is proposed.To minimize the cost and complexity of the canceller,the minimum required number of taps are analyzed.Simulation results show that with the commonly used 12-bits analog-to-digital converter(ADC)at the receiver,the novel optical domain-based canceller can enable efficient SIC in the 3 GPP LTE specifications compatible system within 400 MHz bandwidth. 展开更多
关键词 full-duplex beyond 5G system self-interference cancellation optical domain-based canceller
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Self-Interference Elimination by Physical Feedback Channel in CCFD for 3-D Beamforming Communication 被引量:2
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作者 Naveed Ali Kaimkhani Zhe Chen Fuliang Yin 《China Communications》 SCIE CSCD 2017年第9期62-71,共10页
The 3-D beamforming scheme has elite as evolving interest because of its efficiency to empower assorted techniques such as vertical and horizontal domains and emanation beamforming according to subscriber's provis... The 3-D beamforming scheme has elite as evolving interest because of its efficiency to empower assorted techniques such as vertical and horizontal domains and emanation beamforming according to subscriber's provisions. Usually, 3-D beamforming communication is set up on FDD/TDD approach those effects on the performance of spectrum and energy efficiency. Co-frequency and CoTime Full Duplex(CCFD) is an effective solution to improve the spectrum and energy efficiency by transmitting and receiving simultaneously in frequency and time domain. While, CCFD communication often face the self-interference issue when communication occurs, simultaneously. Consequently, in this paper a self-interference elimination by physical feedback channel in CCFD for 3-D Beamforming communication scheme is proposed to improve the over-all system performance in terms of energy and spectrum efficiency. The simulation and analytical outcomes demonstrated that the proposed system is superior than the traditional one. 展开更多
关键词 spectrum efficiency energy effi-ciency co-frequency and co-time full DUPLEX self-interference suppression 3-D beamform-ing
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Robust Digital Non-Linear Self-Interference Cancellation in Full Duplex Radios with Maximum Correntropy Criterion 被引量:3
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作者 Zhirong Luan Hua Qu +1 位作者 Jihong Zhao Badong Chen 《China Communications》 SCIE CSCD 2016年第9期53-59,共7页
Full duplex radio increases the frequency efficiency but its performance is limited by the self-interference (SI). We first analyze the multiple noises in the full duplex radio system and model such noises as an α ... Full duplex radio increases the frequency efficiency but its performance is limited by the self-interference (SI). We first analyze the multiple noises in the full duplex radio system and model such noises as an α - stable distribution. Then we formulate a novel non-Gaussian SI problem. Under the maximum correntropy criterion (MCC), a robust digital non-linear self-interference cancellation algorithm is proposed for the SI channel estimation. A gradient descent based algorithm is derived to search the optimal solution. Simulation results show that the proposed algorithm can achieve a smaller estimation error and a higher pseudo signal to interference plus noise ratio (PSINR) than the well-known least mean square (LMS) algorithm and least square (LS) algorithm. 展开更多
关键词 full duplex radio robust estimation digital non-linear self-interference can- cellation a-stable noise correntropy
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Polarization Oblique Projection Based Self-Interference Cancellation against PA Nonlinear Distortion in MIMO Full Duplex System 被引量:2
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作者 Wen Zhao Chunyan Feng +1 位作者 Fangfang Liu Caili Guo 《China Communications》 SCIE CSCD 2016年第11期49-59,共11页
In MIMO full duplex system,power amplifier(PA) nonlinearity limits the self-interference(SI) cancellation seriously. Most existing methods need to model and estimate the PA nonlinearity in order to reconstruct the SI,... In MIMO full duplex system,power amplifier(PA) nonlinearity limits the self-interference(SI) cancellation seriously. Most existing methods need to model and estimate the PA nonlinearity in order to reconstruct the SI,however the estimation error caused by the mismatch between the estimated PA model and the actual PA property still impacts the cancellation ability,especially when the transmit power is high. In this paper we propose a polarization oblique projection based self-interference cancellation method which does not need to estimate the PA nonlinearity coefficients. It exploits the polarization state information of the signals which is immune to the PA nonlinearity,and establishes an oblique projection operator to cancel the SI. Numerical results and analysis demonstrate that it can cancel the nonlinear SI effectively. Moreover the signal to interfere plus noise ratio(SINR) and the achievable sum rate do not deteriorate when the transmit power is high. Further,the upper bound of the achievable sum rate can be more than twice that of the half duplex. 展开更多
关键词 full duplex self-interference cancellation PA nonlinearity polarization oblique projection
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A physical layer security scheme for full-duplex communication systems with residual self-interference and non-eavesdropping CSI 被引量:1
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作者 Weijia Lei Yang Zhou Xiuzhen Lin 《Digital Communications and Networks》 SCIE CSCD 2021年第3期352-361,共10页
We discuss the physical layer security scheme in the Full-Duplex(FD)MIMO point-to-point two-way communication system with residual self-interference,in which legitimate nodes send confidential information and null spa... We discuss the physical layer security scheme in the Full-Duplex(FD)MIMO point-to-point two-way communication system with residual self-interference,in which legitimate nodes send confidential information and null space Artificial Noise(AN)while receiving information.Because the Channel State Information(CSI)of the eavesdropper is unavailable,we optimize the covariance matrices of the information signal as well as the allocation of the antenna for transmitting and receiving to minimize the signal power consumption under the target rate constraint.As a result,the power of AN is maximized within the limit of total power,so the interception capability of the eavesdropper is suppressed as much as possible.Since self-interference cannot be completely eliminated,the optimization process of one legitimate node depends on the optimization result of the other.By substituting self-interference power in the secrecy rate formula with its average value,the joint optimization process at the two nodes is transformed into two separate and solvable optimization processes.Then,the Water-Filling Algorithm(WFA)and bisection algorithm are used to get the optimal covariance matrices of the signal.Furthermore,we derive the theoretical lower bound of ergodic achievable secrecy rate under rayleigh channels to evaluate the performance of the scheme.The simulation results show that the theoretical derivation is correct,and the actual achievable rate is very close to the target rate,which means that the approximation in the optimization is feasible.The results also show that secrecy transmission can be realized because a considerable secrecy rate can be achieved. 展开更多
关键词 Physical layer security Full-duplex self-interference Eavesdropping CSI MULTI-ANTENNA
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Adaptive digital self-interference cancellation based on fractional order LMS in LFMCW radar 被引量:6
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作者 LUO Yongjiang BI Luhao ZHAO Dong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第3期573-583,共11页
Adaptive digital self-interference cancellation(ADSIC)is a significant method to suppress self-interference and improve the performance of the linear frequency modulated continuous wave(LFMCW)radar.Due to efficient im... Adaptive digital self-interference cancellation(ADSIC)is a significant method to suppress self-interference and improve the performance of the linear frequency modulated continuous wave(LFMCW)radar.Due to efficient implementation structure,the conventional method based on least mean square(LMS)is widely used,but its performance is not sufficient for LFMCW radar.To achieve a better self-interference cancellation(SIC)result and more optimal radar performance,we present an ADSIC method based on fractional order LMS(FOLMS),which utilizes the multi-path cancellation structure and adaptively updates the weight coefficients of the cancellation system.First,we derive the iterative expression of the weight coefficients by using the fractional order derivative and short-term memory principle.Then,to solve the problem that it is difficult to select the parameters of the proposed method due to the non-stationary characteristics of radar transmitted signals,we construct the performance evaluation model of LFMCW radar,and analyze the relationship between the mean square deviation and the parameters of FOLMS.Finally,the theoretical analysis and simulation results show that the proposed method has a better SIC performance than the conventional methods. 展开更多
关键词 adaptive digital self-interference cancellation(ADSIC) linear frequency modulated continuous wave(LFMCW)radar fractional order least mean square(LMS)
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A Wire-Line Secure Communication System Based on CCFD Self-Interference Cancellation
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作者 LU Wenjian LIU Sanjun LAI Guohong 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2021年第6期507-512,共6页
This paper presents a design scheme of wire-line telephone system using self-interference(SI)cancellation technology in co-frequency co-time full-duplex(CCFD)system to realize absolute secure communication at the phys... This paper presents a design scheme of wire-line telephone system using self-interference(SI)cancellation technology in co-frequency co-time full-duplex(CCFD)system to realize absolute secure communication at the physical layer.This scheme can hide the target signal by skillfully releasing the high-power artificial noise to the whole link at the receiving node,and then make use of the receiver’s knowledge of the SI signal to achieve high dB SI cancellation with the help of analog domain SI cancellation technology in CCFD domain,so that the signal-to-noise ratio(SNR)received by the eavesdropper at any position of the link is far lower than that of the legitimate receiver,so as to realize the absolutely secure communication in the sense of Wyner principle.This paper not only puts forward the specific design scheme of absolutely secure communication telephone,but also analyzes the calculation of security capacity under different eavesdropping positions,different SI cancellation capability and different system parameters according to Shannon theory. 展开更多
关键词 co-frequency co-time full-duplex(CCFD) physical layer security self-interference cancellation security capacity wire-line communication
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All-Digital Self-Interference Cancellation in Zero-IF Full-Duplex Transceivers 被引量:5
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作者 Lu Tian Shuai Wang +1 位作者 Zhiheng Cheng Xiangyuan Bu 《China Communications》 SCIE CSCD 2016年第11期27-34,共8页
In this paper,a general scheme in digital self-interference cancellation at baseband for zero-IF full-duplex transceivers is presented. We model the self-interference signals specifically with only the nonlinear disto... In this paper,a general scheme in digital self-interference cancellation at baseband for zero-IF full-duplex transceivers is presented. We model the self-interference signals specifically with only the nonlinear distortion signals falling in receiving band considered. A joint estimation algorithm is proposed for compensating the time delay and frequency offset taking into account the IQ amplitude and phase imbalances from mixers. The memory effect and nonlinear distortion are adaptively estimated by the de-correlated normalized least mean square(DNLMS) algorithm. Numerical simulation results demonstrate that the proposed self-interference cancellation scheme can efficiently compensate the self-interference and outperform the existing traditional solutions. 展开更多
关键词 communication systems full-duplex transceivers self-interference cancellation IQ imbalance de-correlated normalized least mean square algorithm
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基于卫星信源的省级DTMB单频网组网实践
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作者 王麟 高洋 马小朴 《广播与电视技术》 2025年第5期96-100,共5页
在全国地面数字电视700MHz频率整体迁移工程启动前,各省的电视频道已进行了全面的重新规划设计,并在此基础上展开新一轮的地面数字电视组网实践。在安徽省的频率整体迁移工程实施过程中,通过对各地中央广播电视节目无线数字化覆盖工程... 在全国地面数字电视700MHz频率整体迁移工程启动前,各省的电视频道已进行了全面的重新规划设计,并在此基础上展开新一轮的地面数字电视组网实践。在安徽省的频率整体迁移工程实施过程中,通过对各地中央广播电视节目无线数字化覆盖工程系统的重新设计和合理改造,成功在全省范围内实现了基于卫星信源的DTMB单频网组网目标。本文将对工程建设中的设计方案与实施经验进行系统汇总,以供同行交流参考。 展开更多
关键词 地面数字电视 DTMB 700MHz频率迁移 卫星单频网
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基于SFN-SD的北极冰区船舶航行风险传递路径研究 被引量:6
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作者 席永涛 张靓 +2 位作者 付姗姗 胡甚平 韩冰 《中国安全科学学报》 CAS CSCD 北大核心 2023年第4期52-60,共9页
为明晰北极冰区船舶航行风险传递路径,从人员、船舶、环境、管理4方面识别北极冰区航行风险因素,并应用空间故障网络(SFN)理论和决策试验与评估实验室(DEMATEL)方法,分析船舶北极航行风险事件;采用主观数据获得风险传递概率和传递路径,... 为明晰北极冰区船舶航行风险传递路径,从人员、船舶、环境、管理4方面识别北极冰区航行风险因素,并应用空间故障网络(SFN)理论和决策试验与评估实验室(DEMATEL)方法,分析船舶北极航行风险事件;采用主观数据获得风险传递概率和传递路径,构建北极冰区船舶航行风险传递网络模型;基于永盛轮北极航行记录数据,运用系统动力学(SD)方法,仿真并验证北极冰区船舶航行风险传递网络模型。结果表明:船舶北极航行风险事件中,8种为边缘事件,14种为过程事件,8种为最终事件;从边缘事件到最终事件有15条网络传递路径;经实例验证,所构建的风险传递网络模型可靠;通过该模型能够描述风险事件的传递效应和传递路径,获得最终风险事件的动态概率曲线,揭示北极冰区船舶航行风险传递的规律,为风险防范措施的制定提供技术支持。 展开更多
关键词 空间故障网络(sfn) 系统动力学(SD) 北极冰区 船舶航行风险 传递网络
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CoMP系统的SFN预编码改进算法 被引量:1
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作者 郑凤 陈艺戬 +1 位作者 张婷婷 武穆清 《湖南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2012年第2期82-87,共6页
为提高LTE-Advanced系统小区边缘用户的吞吐量和用户体验,在现有协作多点传输(Coordinated Multi-Point,CoMP)方案基础上提出了两种CoMP系统的单频网(Sin-gle Frequency Network,SFN)预编码改进算法,以改善传统SFN预编码中信道合并的不... 为提高LTE-Advanced系统小区边缘用户的吞吐量和用户体验,在现有协作多点传输(Coordinated Multi-Point,CoMP)方案基础上提出了两种CoMP系统的单频网(Sin-gle Frequency Network,SFN)预编码改进算法,以改善传统SFN预编码中信道合并的不确定性问题.第一种改进算法在发射端的部分传输节点处引入一个便于信道合并的相位参数,并按照合并后信道增益最大的准则确定相位参数的取值;第二种改进算法令部分传输节点的发射数据映射到天线时进行交换操作,同样按照信道增益最大准则确定交换方式.仿真结果表明,两种改进算法能有效提高小区边缘用户的谱效率,且能适用于相干/非相干信道及低/高秩信道的情况. 展开更多
关键词 协作多点传输 sfn预编码 相位控制 吞吐量
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tBHQ和SFN在创伤性脑损伤小鼠中的疗效比较性分析 被引量:2
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作者 刘晓斌 侯明山 +3 位作者 李民 孟发财 黄卫东 宋锦宁 《现代生物医学进展》 CAS 2017年第28期5445-5448,共4页
目的:探讨叔丁基对苯二酚(t BHQ)和莱菔硫烷(SFN)在患有创伤性脑损伤大鼠的疗效差异性。方法:80只健康成年的雄性SD大鼠分为假手术组、常规损伤组、t BHQ治疗组和SFN治疗组,使用电子颅脑损伤仪(e CCI)制备TBI模型。其中t BHQ治疗组在伤... 目的:探讨叔丁基对苯二酚(t BHQ)和莱菔硫烷(SFN)在患有创伤性脑损伤大鼠的疗效差异性。方法:80只健康成年的雄性SD大鼠分为假手术组、常规损伤组、t BHQ治疗组和SFN治疗组,使用电子颅脑损伤仪(e CCI)制备TBI模型。其中t BHQ治疗组在伤前24 h大鼠腹腔注射三次t BHQ(50 mg/kg),每8 h一次;SFN治疗组在伤后15 min给予腹腔注射SFN(5 mg/kg)。给药24 h后,采用m NSS方法评价各组大鼠神经功能缺损状况,利用干湿称量法计算脑含水量,Western blot和ELISA方法分别测定大鼠脑组织的NOX2和Nrf2的表达水平。结果:损伤发生后第24 h,t BHQ治疗组和SFN治疗组在m NSS评分((4.5±0.71)vs(9.2±0.79),(6.0±0.82)vs(9.2±0.79))、脑水肿(79.4%vs 85.6%,80.3%vs 85.6%)、NOX2和Nrf2(0.93 ng/m L vs 0.81 ng/m L,0.87 ng/m L vs 0.81 ng/m L)表达上与常规损伤组差异明显,而t BHQ治疗组和SFN治疗组间在m NSS评分((4.5±0.71)vs(6.0±0.82))、NOX2和Nrf2(0.93 ng/m L vs 0.87 ng/m L)表达上差异显著。结论:在大鼠TBI模型中,t BHQ和SFN均可以有效的降低机体自身的氧化应激作用,并改善神经功能,但t BHQ的疗效要好于SFN。 展开更多
关键词 叔丁基对苯二酚 菜菔硫烷 脑损伤 Nd2 NOX2
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基因工程辅助萝卜硫苷在十字花科作物中的高效生物合成
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作者 刘晓悦 王盼娣 +1 位作者 吴刚 刘芳 《合成生物学》 北大核心 2025年第1期136-156,共21页
植物次级代谢物萝卜硫苷(glucoraphanin,GRA)是一种由蛋氨酸衍生的硫代葡萄糖苷(glucosinolate,GSL),性质相对稳定,其本身及水解后活性产物萝卜硫素(sulforaphane,SFN)在抵抗癌症、神经保护等方面发挥重要作用,在食品营养和科学研究中... 植物次级代谢物萝卜硫苷(glucoraphanin,GRA)是一种由蛋氨酸衍生的硫代葡萄糖苷(glucosinolate,GSL),性质相对稳定,其本身及水解后活性产物萝卜硫素(sulforaphane,SFN)在抵抗癌症、神经保护等方面发挥重要作用,在食品营养和科学研究中受到广泛关注。本文将综述GRA的理化性质、来源、生物学功能、合成途径以及当前生产现状,并进一步探讨未来GRA高效生物合成的潜力策略。GRA合成路径复杂,包括侧链延伸、核心结构形成以及侧链修饰三个阶段,可经植物内源黑芥子酶(myrosinase,MYR)或肠道微生物转化为具有生物活性的SFN等物质。西蓝花等十字花科作物中GRA含量较高,是当前GRA的主要来源作物,但其存在种植周期较长、产量不稳、提取率低等问题,开发经济且可再生的GRA新资源将极大地推进GRA开发应用。随着GRA生物合成及调控路径的明晰,基因工程辅助GRA的高效生物合成展现出巨大的潜力,也提示突破主流的单基因调控策略,聚合多基因多维度协同提高GRA合成的潜力。本文聚焦基因工程辅助十字花科作物高效生产GRA这一目标,系统地梳理了GRA合成各阶段的潜在候选基因并从富集部位角度指出了具高应用价值的底盘作物,以期为将来通过基因工程和分子育种技术调控植物中GRA的生物合成、实现GRA大规模可持续生产,提供一定的思路和策略。 展开更多
关键词 萝卜硫苷(GRA) 萝卜硫素(sfn) 抗癌 基因工程 十字花科作物
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萝卜硫素通过激活p53信号通路抑制胰腺癌PANC-1细胞活性
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作者 任子怡 郭丹悦 +5 位作者 冯丹琦 杨梦 程鑫颖 杨瑞利 刘卫华 王向红 《食品工业科技》 北大核心 2025年第17期420-428,共9页
目的:探讨萝卜硫素(Sulforaphane,SFN)对胰腺癌PANC-1细胞增殖、周期、转移和凋亡的影响及其机制。方法:将PANC-1细胞随机分为四组:对照组(sh-NC)、SFN组(sh-NC+SFN)、实验组(sh-TP53)和sh-TP53+SFN组,并制备不同浓度的SFN溶液(0、6、8... 目的:探讨萝卜硫素(Sulforaphane,SFN)对胰腺癌PANC-1细胞增殖、周期、转移和凋亡的影响及其机制。方法:将PANC-1细胞随机分为四组:对照组(sh-NC)、SFN组(sh-NC+SFN)、实验组(sh-TP53)和sh-TP53+SFN组,并制备不同浓度的SFN溶液(0、6、8、10、16和20μg/mL)。细胞增殖-毒性检测(Cell counting Kit-8,CCK-8)试剂盒检测细胞存活率,划痕实验和Transwell实验检测细胞迁移和侵袭能力,流式细胞术用于分析细胞周期和细胞凋亡能力,蛋白免疫印迹法(Western Blot,WB)检测凋亡蛋白B淋巴细胞瘤-2相关X蛋白(B-cell lymphoma 2 associated X protein,Bax)、B淋巴细胞瘤-2蛋白(B-cell lymphoma 2,Bcl-2)、半胱氨酸天冬氨酸蛋白酶3(Cysteinyl aspartate specific proteinase-3,Caspase-3)和半胱氨酸天冬氨酸蛋白酶9(Cysteinyl aspartate specific proteinase-9,Caspase-9),周期蛋白细胞周期蛋白依赖性激酶1(cyclin-dependent protein kinase 1,CDK1)和细胞周期蛋白B(Cyclin B),转移蛋白基质金属蛋白酶-9(Matrix metallopeptidase-9,MMP-9)和E-钙粘蛋白(E-cadherin),p53信号通路中生长停滞与DNA损伤诱导蛋白45A(growth arrest and DNA damage inducible alpha,GADD45A),细胞周期依赖性蛋白激酶抑制因子1A(cyclin-dependent kinase inhibitors 1A,p21)和肿瘤蛋白p53(Tumor protein p53,TP53)的表达水平,研究SFN对细胞增殖以及p53信号通路的影响。结果:SFN以浓度依赖性的方式抑制PANC-1细胞增殖。与对照组相比,SFN处理后的PANC-1细胞增殖率显著降低(P<0.001);迁移及侵袭能力减弱(P<0.01,P<0.0001);阻滞PANC-1细胞在G2/M期(P<0.0001);同时促进细胞凋亡(P<0.0001);上调Bax、Caspase-3、Caspase-9、E-cadherin、GADD45A、p21和TP53的蛋白水平,下调Bcl-2、CDK1、Cyclin B和MMP-9的蛋白水平(P<0.05,P<0.01,P<0.001,P<0.0001)。与SFN组相比,敲低TP53能显著下调SFN抑制PANC-1细胞增殖、迁移、侵袭和阻滞在G2/M期的能力,显著下调SFN促进PANC-1细胞凋亡的能力,下调Bax、Caspase-3、Caspase-9、E-cadherin、GADD45A、p21和TP53的蛋白水平,上调Bcl-2、CDK1、Cyclin B和MMP-9的蛋白水平(P<0.05,P<0.01,P<0.001,P<0.0001)。结论:SFN抑制胰腺癌PANC-1细胞活性与激活p53信号通路相关。 展开更多
关键词 萝卜硫素 PANC-1 细胞 增殖 转移 凋亡
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CMMB超理论间距SFN设计的研究——CMMB下一阶段建网策略探讨 被引量:6
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作者 李远东 《电视技术》 北大核心 2010年第9期17-20,32,共5页
针对CMMB常规单频网组网所存在的一些突出问题,提出CMMB超理论间距单频网以及CMMB HSFN这两种组网策略。在对常规单频网分析的基础上,总结出CMMB超理论间距单频网设计的理论基础,并认为延时与同频干扰比(CIR)是设计这种单频网时需重点... 针对CMMB常规单频网组网所存在的一些突出问题,提出CMMB超理论间距单频网以及CMMB HSFN这两种组网策略。在对常规单频网分析的基础上,总结出CMMB超理论间距单频网设计的理论基础,并认为延时与同频干扰比(CIR)是设计这种单频网时需重点考虑的两个因素,进而对CMMB单频网进行超理论间距组网的可行性与工程设计、CMMB HSFN组网等进行了探讨。 展开更多
关键词 CMMB 单频网 时延 同频干扰比
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地面数字电视广播单频网(SFN)组网关键技术与测试方法 被引量:10
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作者 杨延冬 呼和 +1 位作者 黄艳萍 吕倩 《中国有线电视》 2014年第B03期374-377,共4页
数字电视是电视信号数字化后的产物,分为有线传输数字电视、卫星传输数字电视、地面无线传输数字电视。地面无线传输数字电视作为电视广播的传统手段,具有简单接收和移动接收的能力,能够满足现代信息化社会"信息到人"的基本... 数字电视是电视信号数字化后的产物,分为有线传输数字电视、卫星传输数字电视、地面无线传输数字电视。地面无线传输数字电视作为电视广播的传统手段,具有简单接收和移动接收的能力,能够满足现代信息化社会"信息到人"的基本需求。数字电视地面广播的传输和使用能克服恶劣环境的影响,从根本上解决了频谱资源紧张的问题,所以数字电视地面广播的推广和产业化将带来不可估量的经济增长。作为地面数字电视广播系统重要组网方式之一的单频网必将随着地面数字电视的发展而迎来高速发展的时期,而国标(DTMB标准)地面数字电视单频网也必将随着DTMB标准的推广及国际化而被更多的国家和地区所采纳,其推广前景广阔。主要阐述地面数字电视广播单频网的组网方式、关键技术与指标、测试方法。 展开更多
关键词 地面数字电视单频网 数字电视发展 关键技术 关键设备
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