Solid lubricating coatings play a crucial role in preventing friction and wear failure of the hot-end sliding components in aviation engines.In this study,VAlN/Ag multi-layer coatings with excellent interfacial matchi...Solid lubricating coatings play a crucial role in preventing friction and wear failure of the hot-end sliding components in aviation engines.In this study,VAlN/Ag multi-layer coatings with excellent interfacial matching were fabricated using a hybrid magnetron sputtering technique.The type and energy of discharge plasmas were analyzed to comprehend their effects on depositing coatings.The coatings exhibit self-adaptive lubrication properties during the designed consecutive friction with stepwise heating from 25℃to 650℃.The microstructure evolution during early friction facilitates sufficient tribo-chemical reaction at 650℃,leading to the formation of a distinctive"ball-on-rail"structure that significantly reduces friction coefficient.Based on the first-principles calculations,it was found that the bond energy of Ag-O is lower than that of V-O in both AgVO_(3)and Ag_(3)VO_(4),which promotes slipping along the(110)crystal plane and contributes to exceptional tribological properties.The fatigue wear failure mechanism of hard coatings under the thermal-force coupling effects has been elucidated,alongside an exploration of consecutive tribology mechanism at atomic scales over a wide temperature range.展开更多
Thermal spray, such as direct current （d.c.） plasma spray or radio frequency induced plasma spray, was used to deposit tungsten coatings on the copper electrodes of a tokamak device. The tungsten coating on the oute...Thermal spray, such as direct current （d.c.） plasma spray or radio frequency induced plasma spray, was used to deposit tungsten coatings on the copper electrodes of a tokamak device. The tungsten coating on the outer surface of one copper electrode was formed directly through d.c. plasma spraying of fine tungsten powder. The tungsten coating/lining on the inner surface of another copper electrode could be formed indirectly through induced plasma spraying of coarse tungsten powder. Scanning electron microscopy （SEM） was used to examine the cross section and the interface of the tungsten coating. Energy Dispersive Analysis of X-ray （EDAX） was used to analyze the metallic elements attached to a separated interface. The influence of the particle size of the tungsten powder on the density, cracking behavior and adhesion of the coating is discussed. It is found that the coarse tungsten powder with the particle size of 45-75μm can be melted and the coating can be formed only by using induced plasma. The coating deposited from the coarse powder has much higher cohesive strength, adhesive strength and crack resistance than the coating made from the fine powder with a particle size of 5μm.展开更多
Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generat...Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generation was reported to realize up-regulation of cyclic guanosine monophosphate(c GMP)and improve hemocompatibility for diverse metal materials.We first introduce the active centre selenocysteine of glutathione peroxidase(GPx)to the self-assembling peptide(RADA)4,obtaining a functionalized hydrogel.Then the hydrogel is directly coated on the 316L stainless steel(SS)for catalytically generating NO from endogenous s-nitrosothiols(RSNO).The generated NO endows the coated surface with regulation of platelet behavior and reduction of plasmatic coagulation activation and complement system activation,hence improving antithrombotic ability in vitro and ex vivo.Overall,our NO-generating hydrogel coating surface engineering strategy provides a novel solution to remove the obstacle about thrombosis of blood-contacting devices in clinic.展开更多
The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient survival.The traditionally used silicone tube stent is not only complicated to operate but also ...The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient survival.The traditionally used silicone tube stent is not only complicated to operate but also lacks antitumor properties.The purpose of this study was to develop a dual-layer drug-coated pancreaticojejunostomy device.The coating consisted of two layers,an outer basic fibroblast growth factor(bFGF)coating layer and an inner nanoparticle albumin-bound paclitaxel(nab-PTX)coating layer with chitosan as the drug-carrying medium.Due to the diffusion barrier from the outer coating,the release of nab-PTX from the inner layer was delayed and slowed down.We studied the degradation rates,mechanical properties,surface morphologies,drug release kinetics,promoting the growth of fibroblasts and antitumor properties of the coated stents.It was found that 100 ng of bFGF and 50µg of nab-PTX were suitable drug concentrations that can effectively promote the growth of fibroblasts and inhibit pancreatic cancer cells.The results also confirmed that the dual-layer drug-coated pancreaticojejunostomy device showed good antitumor activity both in vitro and in vivo without obvious systemic toxicity.In addition,the device has a suitable degradation rate.In conclusion,this biodegradable dual-layer drug-coated pancreaticojejunostomy device can potentially inhibit the local recurrence of pancreatic cancer after surgery and promote the healing of pancreaticointestinal anastomosis.This device has great potential to treat pancreatic cancer in the future.展开更多
The control design, based on self-adaptive PID with genetic algorithms(GA) tuning on-line was investigated, for the temperature control of industrial microwave drying rotary device with the multi-layer(IMDRDWM) and wi...The control design, based on self-adaptive PID with genetic algorithms(GA) tuning on-line was investigated, for the temperature control of industrial microwave drying rotary device with the multi-layer(IMDRDWM) and with multivariable nonlinear interaction of microwave and materials. The conventional PID control strategy incorporated with optimization GA was put forward to maintain the optimum drying temperature in order to keep the moisture content below 1%, whose adaptation ability included the cost function of optimization GA according to the output change. Simulations on five different industrial process models and practical temperature process control system for selenium-enriched slag drying intensively by using IMDRDWM were carried out systematically, indicating the reliability and effectiveness of control design. The parameters of proposed control design are all on-line implemented without iterative predictive calculations, and the closed-loop system stability is guaranteed, which makes the developed scheme simpler in its synthesis and application, providing the practical guidelines for the control implementation and the parameter design.展开更多
Sand mold 3 D printing technology is an advanced manufacturing technology which has great flexible manufacturing ability. A multi-material composite sand mold can control the temperature field of metallic parts during...Sand mold 3 D printing technology is an advanced manufacturing technology which has great flexible manufacturing ability. A multi-material composite sand mold can control the temperature field of metallic parts during the pouring process, while the current sand mold 3 D printing technology can only fabricate a single material sand mold. The casting temperature field can not be adjusted by using single sand mold material with isotropous heat exchange ability during the pouring process. In this work, a kind of novel coating device was designed. Multi-material composite sand molds could be manufactured using the coating device according to the casting process demands of the final parts. The influences of curing agent content, coating velocity and scraper shape on compactness and surface roughness of the sand layer(silica sand and zircon sand) were studied. The shapes and sizes of transition intervals of two kinds of sand granules were also tested. The results show that, with the increase of the added volume of curing agent, the compactness of sand layer reduces and the surface roughness value rises. With the increase of the velocity of the coating device, the compactness of sand layer reduces and the surface roughness value rises similarly. In addition, the scraper with a dip angle of 72 degrees could increase the compactness value of the sand layer. The criteria of quality parmeters of the coating procedure are obtained. That is, the surface roughness(δ) of sand layer should be equal to or lesser than half of main size of the sand particles(Dm). The parameter H of the coating device which is the distance between the base of hopper and the surface of sand layer impacts the size of transition zone. The width of the transition zone is in direct proportion to the parameter H, qualitatively. Through the optimization of the coating device, high quality of multi-material sand layers can be obtained. This will provide a solution in manufacturing the multi-material composite sand mold.展开更多
Implantable electronic devices(IEDs)are widely used by human beings to achieve medical treatment and diagnosis nowadays.However,ideal encapsulation of IEDs is still far from perfect as full prevention of body fluid di...Implantable electronic devices(IEDs)are widely used by human beings to achieve medical treatment and diagnosis nowadays.However,ideal encapsulation of IEDs is still far from perfect as full prevention of body fluid diffusion into the coating remains unsolved.Herein,we develop a high-performance composite coating for IED encapsulation by introducing SiO_(2) nanoparticles into silicone rubber,which synergistically enhances mechanical properties and improves barrier performance.By fabricating composite coatings with different nanosilica contents,3%nanosilica is proved to be an optimal additive content with an excellent combination of improved fracture strength(from 2.5 MPa to 4.5 MPa),increased coating resistance(from 10^(4) to 10^(9) cm^(2))and ideal coating uniformity.Mechanical and electrochemical characterizations subsequently confirm substantially enhanced mechanical properties and barrier performance of the composite coating,which effectively resist crack propagation and impede penetrations of water and chloride ions through the coating.Theoretical calculations further uncover that modified SiO_(2) particles with enriched methyl groups endow a strong bridging effect to interact with silicone rubber monomer,which,together with anti-agglomeration property of methyl groups,contributes to a pronounced improvement in mechanical performance of nanosilica-filled silicone rubber.Benefitting from the enhanced mechanical and barrier properties,the as-fabricated nanosilica-filled silicone rubber demonstrates superior protection for the encapsulated circuits with a significantly improved lifetime(709.1 h)compared to that of circuits coated by pure silicone rubber(472.8 h)and bare circuit boards(1 h),which offers great values for packaging material design in future IED encapsulation.展开更多
It is known that fiber wastes (lint, down and seeds) produced at ginneries contain fibers that are suitable for spinning and can be used in industry, and their separation significantly increases the level of fiber pro...It is known that fiber wastes (lint, down and seeds) produced at ginneries contain fibers that are suitable for spinning and can be used in industry, and their separation significantly increases the level of fiber production (1.9% - 2.5%). Based on these analyzes, the study aimed to create a new device that separates long fibers from lint and down. As a result, the amount of fiber output in the enterprise will increase and the enterprise will have significant economic benefits. In addition, the introduction of the device will prevent the addition of long fibers (longer than 16 mm) that can be used in the textile industry to the waste. This article focuses on the creation of a fiber separation device suitable for the treatment and spinning of fibrous waste produced in ginneries. The study theoretically examined the main working bodies of the fiber separation device from waste. Theoretical research is devoted to the study of the strength of the main working body of the fiber separation device<span style="white-space:nowrap;">−</span>the separating saw drum and its shaft. In the study, the sawdust drum is a more stressed steel coating, and it was found that the strength reserve of this drum is [<span style="white-space:nowrap;"><em>δ</em></span><sub>Т</sub>] = 2.03 (where <em>δ</em><sub>Т</sub> = 0.8 - 2.5) was found to be. As a result of calculating the resistance of the saw drum shaft to stiffness and vibration, it was determined that the shafts are resistant to vibration under periodic loading and that the oscillation frequency along its axis through the critical rotation frequency is <em>v<sub>cr</sub></em>=10.3 Gts.展开更多
The modified empirical two-temperature model of surface burning on a foam metal matrix was proposed. The comparative experimental studies of radiation properties of both matrices without and with ceramic coating (alum...The modified empirical two-temperature model of surface burning on a foam metal matrix was proposed. The comparative experimental studies of radiation properties of both matrices without and with ceramic coating (alumina) were carried out. Measurement was conducted in different spectral ranges. The experimental results were compared with theoretical calculations. It was shown that the integral radiation efficiency of the matrix with ceramic coating was comparable with radiation efficiency of the matrix without any coating in the wide range of the firing rate and surpassed it on 30% - 40% at firing rate above 50 W/cm2.展开更多
This article examines the technological parameters of the device for the separation of fibers suitable for spinning by processing fibrous waste from the technological processes of ginneries. Technological processes in...This article examines the technological parameters of the device for the separation of fibers suitable for spinning by processing fibrous waste from the technological processes of ginneries. Technological processes in the cotton ginning industry include a complex of physical and mechanical advantages, the successful study of which is possible only with the use of modern achievements in science and technology. Therefore, it is advisable to conduct scientific research based on mathematical modeling. To justify the effective operation of the selected design of the cotton fiber separation device, it is necessary to select its optimal technological parameters. Improving the efficiency of the process of separation of spinning fibers from the composition of fibrous waste depends directly on technological parameters. The application of mathematical methods in the planning and conduct of research allows for determining the individual effects of the interaction of several factors that characterize the combined parameters of the optimization parameters, in contrast to traditional computational methods of research. As a result, it will be possible to obtain a mathematical model of the object understudy in a relatively small number of tests, which will simultaneously serve to obtain optimal solutions.展开更多
Filtration surgery still plays a mainstream role of treatment for glaucoma.Postoperative scarring is the main cause of surgical failure.This study evaluated the biocompatibility and anti-proliferative properties of pu...Filtration surgery still plays a mainstream role of treatment for glaucoma.Postoperative scarring is the main cause of surgical failure.This study evaluated the biocompatibility and anti-proliferative properties of pure magnesium with three different coatings,which are hydroxyapatite(HA),dicalcium phosphate dihydrate(DCPD)and DCPD+stearic acid(SA),in a primary culture of human tenon's capsule fibroblasts(HTCFs)and in rabbit Glaucoma Filtration Surgery.Titanium and glass were used as controls in vitro,and trabeculectomy was used as control in vivo.The results show the number and shape of HTCFs seeded on different coatings showed less quantity and poor cell morphology.Each type of coated magnesium demonstrated significantly decreased metabolic activity of HTCFs.DCPD+SA showed higher cytotoxicity than the other coatings.Significant inhibition of proliferation was observed with the DCPD+SA coating.The expression ofα-SMA was decreased in the cells when seeded on all of the coated magnesium disks.In vivo,no obvious adverse effects were observed after operation.No significant difference existed for any of the different samples regarding different ion concentrations in the aqueous humor.The inflammatory response in the titanium,DCPD and DCPD+SA treated eyes was more intense than in the trabeculectomy alone and HA groups.Western Blot analysis showed that collagen-1 andα-SMA expression was significantly lower in the titanium,HA,DCPD and DCPD+SA groups compared with the control.Different coatings on magnesium were able to affect the corrosive properties,which in turn,influenced the morphology and function of HTCFs.HA coated magnesium may be considered a very promising biodegradable material for the next generation of glaucoma drainage devices.展开更多
Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to the...Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent functional endothelium. Here, inspired by the pathological mechanisms of vascular device failure and physiological functions of native endothelium, we developed a new generation of bioactive parylene (poly(p-xylylene))-based conformal coating to address these challenges of the vascular devices. This coating used a polyethylene glycol (PEG) linker to introduce an endothelial progenitor cell (EPC) specific binding ligand LXW7 (cGRGDdvc) onto the vascular devices for preventing platelet adhesion and selectively capturing endogenous EPCs. Also, we confirmed the long-term stability and function of this coating in human serum. Using two vascular disease-related large animal models, a porcine carotid artery interposition model and a porcine carotid artery-jugular vein arteriovenous graft model, we demonstrated that this coating enabled rapid generation of self-renewable “living” endothelium on the blood contacting surface of the expanded polytetrafluoroethylene (ePTFE) grafts after implantation. We expect this easy-to-apply conformal coating will present a promising avenue to engineer surface properties of “off-the-shelf” implantable vascular devices for long-lasting performance in the clinical settings.展开更多
Organic polymer coatings have been commonly used in biomedical field,which play an important role in achieving biological antifouling,drug delivery,and bacteriostasis.With the continuous development of polymer science...Organic polymer coatings have been commonly used in biomedical field,which play an important role in achieving biological antifouling,drug delivery,and bacteriostasis.With the continuous development of polymer science,organic polymer coatings can be designed with complex and advanced functions,which is conducive to the construction of biomedical materials with different performances.According to different physical and chemical properties of materials,biomedical organic polymer coating materials are classified into zwitterionic polymers,non-ionic polymers,and biomacromolecules.The strategies of combining coatings with substrates include physical adsorption,chemical grafting,and self-adhesion.Though the coating materials and construction methods are different,many biomedical polymer coatings have been developed to achieve excellent performances,i.e.,enhanced lubrication,anti-inflammation,antifouling,antibacterial,drug release,anti-encrustation,anti-thrombosis,etc.Consequently,a large number of biomedical polymer coatings have been used in artificial lungs,ureteral stent,vascular flow diverter,and artificial joints.In this review,we summarize different types,properties,construction methods,biological functions,and clinical applications of biomedical organic polymer coatings,and prospect future direction for development of organic polymer coatings in biomedical field.It is anticipated that this review can be useful for the design and synthesis of functional organic polymer coatings with various biomedical purposes.展开更多
White organic light-emitting device (WOLEDs) employing molecular mixed host (MH) is demonstrated by spin-coating.The spin-coated film functions as light-emitting layer and hole transporting layer,with the former forme...White organic light-emitting device (WOLEDs) employing molecular mixed host (MH) is demonstrated by spin-coating.The spin-coated film functions as light-emitting layer and hole transporting layer,with the former formed by spin-coating solution containing MH of NPB (N.N'-Bis(naphthalene-1-yl)-N,N'-bis(phenyl)-benzidine) and MADN (2-methyl-9,10-di(2-naphthyl) anthracene),blue dye (4,4'-bis[2-(4-(N,N-diphenylamino)phenyl)vinyl]biphenyl) and yellow dye (5,6,11,12-tetraphenylnaphacene).The performances of the devices made with different mixed ratio of MH are investigated.It is found that the device performances depends on the MH ratio,and under the optimal NPB:MADN ratio (60:40),the WOLEDs show a maximum luminance of 24 671 cd/m2 and a current efficiency of 5.8 cd/A for the practical luminance of 1000 cd/m2.The effect of MH ratio on device performances can be attributed to the difference of hole mobility between the NPB and MADN.展开更多
The current collector is a crucial component in lithium-ion batteries and supercapacitor setups,responsible for gathering electrons from electrode materials and directing them into the external circuit.However,as batt...The current collector is a crucial component in lithium-ion batteries and supercapacitor setups,responsible for gathering electrons from electrode materials and directing them into the external circuit.However,as battery systems evolve and the demand for higher energy density increases,the limitations of traditional current collectors,such as high contact resistance and low corrosion resistance,have become increasingly evident.This review investigates the functions and challenges associated with current collectors in modern battery and supercapacitor systems,with a particular focus on using carbon coating methods to enhance their performance.Surface coating,known for its simplicity and wide applicability,emerges as a promising solution to address these challenges.The review provides a comprehensive overview of carbon-coated current collectors across various types of metal and nonmetal substrates in lithium-ion batteries and supercapacitors,including a comparative analysis of coating materials and techniques.It also discusses methods for manufacturing carbon-coated current collectors and their practical implications for the industry.Furthermore,the review explores prospects and opportunities,highlighting the development of next-generation high-performance coatings and emphasizing the importance of advanced current collectors in optimizing energy device performance.展开更多
Towards the development of highly efficient electrochromic coatings,the crystallinity,morphology(e.g.size and shape)of electrochromic nanomaterials,and their charge insertion capacities play a significant role.Herein,...Towards the development of highly efficient electrochromic coatings,the crystallinity,morphology(e.g.size and shape)of electrochromic nanomaterials,and their charge insertion capacities play a significant role.Herein,we report the structure-dependent colouration effciency in electrochromic coatings based on the use of 0D,1D and 2D tungsten trioxide(WO_(3))nanostructures.A series of WO_(3)with different nanostructures were prepared and used as working electrodes to fabricate electrochromic devices for smart windows applications.Facile spray coating was applied on fluorine-doped tin oxide(FTO)substrate to make~70%transparent working electrodes to investigate their charge insertion capacities,electrochromic active surface area,and colouration efficiency.Results showed that the 2D WO_(3)nanoflakes displayed the highest diffusion coefficient for the intercalation of 1.52×10^(-10)cm^(2)/s with an increased electrochemical active surface area of 25.10 mF/cm^(2),a large modulation of optical reflectance(42.63%)with 3.79 s shorter response time for bleaching and a greater colouration efficiency(CE)value(89.29 cm^(2)/C)at 700 nm compared to the CE value for 1D WO_(3)(of 22 cm^(2)/C)and 0D WO_(3)(8 cm^(2)/C).The outcome of this study provides a new insight and valuable contribution to design an efficient electrochromic coating by controlling and optimising the nanostructures of selective electrochromic materials.展开更多
TRISO （Tri-structural iso-tropic）-coated particle fuel is being developed to support the development of a VHTR （very high temperature reactor） in Korea. From August 2013, the first irradiation testing of coated pa...TRISO （Tri-structural iso-tropic）-coated particle fuel is being developed to support the development of a VHTR （very high temperature reactor） in Korea. From August 2013, the first irradiation testing of coated particle fuel was begun to demonstrate and qualify TRISO fuel for use in the VHTR in HANARO （high-flux advanced neutron application reactor） at KAERI （Korea Atomic Energy Research Institute）. This experiment is currently undergoing under an atmosphere of a mixed inert gas without on-line temperature monitoring and control combined with on-line fission product monitoring of the sweep gas. The irradiation device contains two test rods, one contains nine fuel compacts and the other five compacts and eight graphite specimens. Each compact has 263 coated particles. After a peak bum-up of about 4% and a peak fast neutron fluence of about 1.7 × 1021 n/cm2, PIE （post irradiation examination） will be carried out at KAERI＇s irradiated material examination facility. This paper describes the characteristics of coated particle fuels, and the design of the test rod and irradiation device for the coated particle fuels, and discusses the technical results of irradiation testing at HANARO.展开更多
基金supported by the National Natural Science Foundation of China(No.52025014)Natural Science Foundation of Zhejiang Province(No.LQ23E010002)+1 种基金Natural Science Foundation of Ningbo(No.2023QL049)Major Special Project of Ningbo(No.2023Z022).
文摘Solid lubricating coatings play a crucial role in preventing friction and wear failure of the hot-end sliding components in aviation engines.In this study,VAlN/Ag multi-layer coatings with excellent interfacial matching were fabricated using a hybrid magnetron sputtering technique.The type and energy of discharge plasmas were analyzed to comprehend their effects on depositing coatings.The coatings exhibit self-adaptive lubrication properties during the designed consecutive friction with stepwise heating from 25℃to 650℃.The microstructure evolution during early friction facilitates sufficient tribo-chemical reaction at 650℃,leading to the formation of a distinctive"ball-on-rail"structure that significantly reduces friction coefficient.Based on the first-principles calculations,it was found that the bond energy of Ag-O is lower than that of V-O in both AgVO_(3)and Ag_(3)VO_(4),which promotes slipping along the(110)crystal plane and contributes to exceptional tribological properties.The fatigue wear failure mechanism of hard coatings under the thermal-force coupling effects has been elucidated,alongside an exploration of consecutive tribology mechanism at atomic scales over a wide temperature range.
基金supported by the Canadian Fusion Fuels Technology Project
文摘Thermal spray, such as direct current （d.c.） plasma spray or radio frequency induced plasma spray, was used to deposit tungsten coatings on the copper electrodes of a tokamak device. The tungsten coating on the outer surface of one copper electrode was formed directly through d.c. plasma spraying of fine tungsten powder. The tungsten coating/lining on the inner surface of another copper electrode could be formed indirectly through induced plasma spraying of coarse tungsten powder. Scanning electron microscopy （SEM） was used to examine the cross section and the interface of the tungsten coating. Energy Dispersive Analysis of X-ray （EDAX） was used to analyze the metallic elements attached to a separated interface. The influence of the particle size of the tungsten powder on the density, cracking behavior and adhesion of the coating is discussed. It is found that the coarse tungsten powder with the particle size of 45-75μm can be melted and the coating can be formed only by using induced plasma. The coating deposited from the coarse powder has much higher cohesive strength, adhesive strength and crack resistance than the coating made from the fine powder with a particle size of 5μm.
基金financially supported by the National Natural Science Foundation of China(Nos.82072072,32171326 and 31800795)the International Cooperation Project by the Science and Technology Department of Sichuan Province(No.2021YFH0056)+1 种基金the Sichuan Science and Technology Program(No.2021JDRC0160)the High-level Talents Research and Development Program of Affiliated Dongguan Hospital(No.K202102)。
文摘Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generation was reported to realize up-regulation of cyclic guanosine monophosphate(c GMP)and improve hemocompatibility for diverse metal materials.We first introduce the active centre selenocysteine of glutathione peroxidase(GPx)to the self-assembling peptide(RADA)4,obtaining a functionalized hydrogel.Then the hydrogel is directly coated on the 316L stainless steel(SS)for catalytically generating NO from endogenous s-nitrosothiols(RSNO).The generated NO endows the coated surface with regulation of platelet behavior and reduction of plasmatic coagulation activation and complement system activation,hence improving antithrombotic ability in vitro and ex vivo.Overall,our NO-generating hydrogel coating surface engineering strategy provides a novel solution to remove the obstacle about thrombosis of blood-contacting devices in clinic.
基金financially supported by the National Natural Science Foundation of China(No.82072074)the National Natural Science Foundation of China(No.82001895)+1 种基金the Joint Funds of Scientific and Technological Innovation Program of Fujian Province(No.2020Y9064)the Joint Funds of Scientific and Technological Innovation Program of Fujian Province(No.2018Y9039).
文摘The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient survival.The traditionally used silicone tube stent is not only complicated to operate but also lacks antitumor properties.The purpose of this study was to develop a dual-layer drug-coated pancreaticojejunostomy device.The coating consisted of two layers,an outer basic fibroblast growth factor(bFGF)coating layer and an inner nanoparticle albumin-bound paclitaxel(nab-PTX)coating layer with chitosan as the drug-carrying medium.Due to the diffusion barrier from the outer coating,the release of nab-PTX from the inner layer was delayed and slowed down.We studied the degradation rates,mechanical properties,surface morphologies,drug release kinetics,promoting the growth of fibroblasts and antitumor properties of the coated stents.It was found that 100 ng of bFGF and 50µg of nab-PTX were suitable drug concentrations that can effectively promote the growth of fibroblasts and inhibit pancreatic cancer cells.The results also confirmed that the dual-layer drug-coated pancreaticojejunostomy device showed good antitumor activity both in vitro and in vivo without obvious systemic toxicity.In addition,the device has a suitable degradation rate.In conclusion,this biodegradable dual-layer drug-coated pancreaticojejunostomy device can potentially inhibit the local recurrence of pancreatic cancer after surgery and promote the healing of pancreaticointestinal anastomosis.This device has great potential to treat pancreatic cancer in the future.
基金Project(51090385) supported by the Major Program of National Natural Science Foundation of ChinaProject(2011IB001) supported by Yunnan Provincial Science and Technology Program,China+1 种基金Project(2012DFA70570) supported by the International Science & Technology Cooperation Program of ChinaProject(2011IA004) supported by the Yunnan Provincial International Cooperative Program,China
文摘The control design, based on self-adaptive PID with genetic algorithms(GA) tuning on-line was investigated, for the temperature control of industrial microwave drying rotary device with the multi-layer(IMDRDWM) and with multivariable nonlinear interaction of microwave and materials. The conventional PID control strategy incorporated with optimization GA was put forward to maintain the optimum drying temperature in order to keep the moisture content below 1%, whose adaptation ability included the cost function of optimization GA according to the output change. Simulations on five different industrial process models and practical temperature process control system for selenium-enriched slag drying intensively by using IMDRDWM were carried out systematically, indicating the reliability and effectiveness of control design. The parameters of proposed control design are all on-line implemented without iterative predictive calculations, and the closed-loop system stability is guaranteed, which makes the developed scheme simpler in its synthesis and application, providing the practical guidelines for the control implementation and the parameter design.
基金financially supported by the National Excellent Young Scientists Fund(NO.51525503)
文摘Sand mold 3 D printing technology is an advanced manufacturing technology which has great flexible manufacturing ability. A multi-material composite sand mold can control the temperature field of metallic parts during the pouring process, while the current sand mold 3 D printing technology can only fabricate a single material sand mold. The casting temperature field can not be adjusted by using single sand mold material with isotropous heat exchange ability during the pouring process. In this work, a kind of novel coating device was designed. Multi-material composite sand molds could be manufactured using the coating device according to the casting process demands of the final parts. The influences of curing agent content, coating velocity and scraper shape on compactness and surface roughness of the sand layer(silica sand and zircon sand) were studied. The shapes and sizes of transition intervals of two kinds of sand granules were also tested. The results show that, with the increase of the added volume of curing agent, the compactness of sand layer reduces and the surface roughness value rises. With the increase of the velocity of the coating device, the compactness of sand layer reduces and the surface roughness value rises similarly. In addition, the scraper with a dip angle of 72 degrees could increase the compactness value of the sand layer. The criteria of quality parmeters of the coating procedure are obtained. That is, the surface roughness(δ) of sand layer should be equal to or lesser than half of main size of the sand particles(Dm). The parameter H of the coating device which is the distance between the base of hopper and the surface of sand layer impacts the size of transition zone. The width of the transition zone is in direct proportion to the parameter H, qualitatively. Through the optimization of the coating device, high quality of multi-material sand layers can be obtained. This will provide a solution in manufacturing the multi-material composite sand mold.
基金supported by the National Natural Science Foundation of China(Nos.51871227 and 52271079).
文摘Implantable electronic devices(IEDs)are widely used by human beings to achieve medical treatment and diagnosis nowadays.However,ideal encapsulation of IEDs is still far from perfect as full prevention of body fluid diffusion into the coating remains unsolved.Herein,we develop a high-performance composite coating for IED encapsulation by introducing SiO_(2) nanoparticles into silicone rubber,which synergistically enhances mechanical properties and improves barrier performance.By fabricating composite coatings with different nanosilica contents,3%nanosilica is proved to be an optimal additive content with an excellent combination of improved fracture strength(from 2.5 MPa to 4.5 MPa),increased coating resistance(from 10^(4) to 10^(9) cm^(2))and ideal coating uniformity.Mechanical and electrochemical characterizations subsequently confirm substantially enhanced mechanical properties and barrier performance of the composite coating,which effectively resist crack propagation and impede penetrations of water and chloride ions through the coating.Theoretical calculations further uncover that modified SiO_(2) particles with enriched methyl groups endow a strong bridging effect to interact with silicone rubber monomer,which,together with anti-agglomeration property of methyl groups,contributes to a pronounced improvement in mechanical performance of nanosilica-filled silicone rubber.Benefitting from the enhanced mechanical and barrier properties,the as-fabricated nanosilica-filled silicone rubber demonstrates superior protection for the encapsulated circuits with a significantly improved lifetime(709.1 h)compared to that of circuits coated by pure silicone rubber(472.8 h)and bare circuit boards(1 h),which offers great values for packaging material design in future IED encapsulation.
文摘It is known that fiber wastes (lint, down and seeds) produced at ginneries contain fibers that are suitable for spinning and can be used in industry, and their separation significantly increases the level of fiber production (1.9% - 2.5%). Based on these analyzes, the study aimed to create a new device that separates long fibers from lint and down. As a result, the amount of fiber output in the enterprise will increase and the enterprise will have significant economic benefits. In addition, the introduction of the device will prevent the addition of long fibers (longer than 16 mm) that can be used in the textile industry to the waste. This article focuses on the creation of a fiber separation device suitable for the treatment and spinning of fibrous waste produced in ginneries. The study theoretically examined the main working bodies of the fiber separation device from waste. Theoretical research is devoted to the study of the strength of the main working body of the fiber separation device<span style="white-space:nowrap;">−</span>the separating saw drum and its shaft. In the study, the sawdust drum is a more stressed steel coating, and it was found that the strength reserve of this drum is [<span style="white-space:nowrap;"><em>δ</em></span><sub>Т</sub>] = 2.03 (where <em>δ</em><sub>Т</sub> = 0.8 - 2.5) was found to be. As a result of calculating the resistance of the saw drum shaft to stiffness and vibration, it was determined that the shafts are resistant to vibration under periodic loading and that the oscillation frequency along its axis through the critical rotation frequency is <em>v<sub>cr</sub></em>=10.3 Gts.
文摘The modified empirical two-temperature model of surface burning on a foam metal matrix was proposed. The comparative experimental studies of radiation properties of both matrices without and with ceramic coating (alumina) were carried out. Measurement was conducted in different spectral ranges. The experimental results were compared with theoretical calculations. It was shown that the integral radiation efficiency of the matrix with ceramic coating was comparable with radiation efficiency of the matrix without any coating in the wide range of the firing rate and surpassed it on 30% - 40% at firing rate above 50 W/cm2.
文摘This article examines the technological parameters of the device for the separation of fibers suitable for spinning by processing fibrous waste from the technological processes of ginneries. Technological processes in the cotton ginning industry include a complex of physical and mechanical advantages, the successful study of which is possible only with the use of modern achievements in science and technology. Therefore, it is advisable to conduct scientific research based on mathematical modeling. To justify the effective operation of the selected design of the cotton fiber separation device, it is necessary to select its optimal technological parameters. Improving the efficiency of the process of separation of spinning fibers from the composition of fibrous waste depends directly on technological parameters. The application of mathematical methods in the planning and conduct of research allows for determining the individual effects of the interaction of several factors that characterize the combined parameters of the optimization parameters, in contrast to traditional computational methods of research. As a result, it will be possible to obtain a mathematical model of the object understudy in a relatively small number of tests, which will simultaneously serve to obtain optimal solutions.
基金funded by Natural Science Foundation of China(Grant number 81470629)Natural Science Foundation of Chongqing(Grant number cstc2018jcyjAX0016)。
文摘Filtration surgery still plays a mainstream role of treatment for glaucoma.Postoperative scarring is the main cause of surgical failure.This study evaluated the biocompatibility and anti-proliferative properties of pure magnesium with three different coatings,which are hydroxyapatite(HA),dicalcium phosphate dihydrate(DCPD)and DCPD+stearic acid(SA),in a primary culture of human tenon's capsule fibroblasts(HTCFs)and in rabbit Glaucoma Filtration Surgery.Titanium and glass were used as controls in vitro,and trabeculectomy was used as control in vivo.The results show the number and shape of HTCFs seeded on different coatings showed less quantity and poor cell morphology.Each type of coated magnesium demonstrated significantly decreased metabolic activity of HTCFs.DCPD+SA showed higher cytotoxicity than the other coatings.Significant inhibition of proliferation was observed with the DCPD+SA coating.The expression ofα-SMA was decreased in the cells when seeded on all of the coated magnesium disks.In vivo,no obvious adverse effects were observed after operation.No significant difference existed for any of the different samples regarding different ion concentrations in the aqueous humor.The inflammatory response in the titanium,DCPD and DCPD+SA treated eyes was more intense than in the trabeculectomy alone and HA groups.Western Blot analysis showed that collagen-1 andα-SMA expression was significantly lower in the titanium,HA,DCPD and DCPD+SA groups compared with the control.Different coatings on magnesium were able to affect the corrosive properties,which in turn,influenced the morphology and function of HTCFs.HA coated magnesium may be considered a very promising biodegradable material for the next generation of glaucoma drainage devices.
基金supported by the UC Davis School of Medicine Dean’s Fellowship award,the Science Translation and Innovative Research(STAIR)grant offered by UC Davis Venture Catalyst,the National Heart,Lung,And Blood Institute under Award Number T32 HL086350 and U54HL 119893 through UC BRAID Center for Accelerated Innovation Technology Grant,and California Institute for Regenerative Medicine(CIRM)grant(TRAN3-13332).The authors would also like to thank the Combinatorial Chemistry Shared Resource at University of California Davis for assistance with design and synthesis of peptides and their derivativesUtilization of this Shared Resource was supported by the UC Davis Comprehensive Cancer Center Support Grant awarded by the National Cancer Institute(P30CA093373).
文摘Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent functional endothelium. Here, inspired by the pathological mechanisms of vascular device failure and physiological functions of native endothelium, we developed a new generation of bioactive parylene (poly(p-xylylene))-based conformal coating to address these challenges of the vascular devices. This coating used a polyethylene glycol (PEG) linker to introduce an endothelial progenitor cell (EPC) specific binding ligand LXW7 (cGRGDdvc) onto the vascular devices for preventing platelet adhesion and selectively capturing endogenous EPCs. Also, we confirmed the long-term stability and function of this coating in human serum. Using two vascular disease-related large animal models, a porcine carotid artery interposition model and a porcine carotid artery-jugular vein arteriovenous graft model, we demonstrated that this coating enabled rapid generation of self-renewable “living” endothelium on the blood contacting surface of the expanded polytetrafluoroethylene (ePTFE) grafts after implantation. We expect this easy-to-apply conformal coating will present a promising avenue to engineer surface properties of “off-the-shelf” implantable vascular devices for long-lasting performance in the clinical settings.
基金supported by the National Natural Science Foundation of China(Nos.52275199 and 52335004)Beijing–Tianjin–Hebei Fundamental Research Cooperation Project(No.J230001).
文摘Organic polymer coatings have been commonly used in biomedical field,which play an important role in achieving biological antifouling,drug delivery,and bacteriostasis.With the continuous development of polymer science,organic polymer coatings can be designed with complex and advanced functions,which is conducive to the construction of biomedical materials with different performances.According to different physical and chemical properties of materials,biomedical organic polymer coating materials are classified into zwitterionic polymers,non-ionic polymers,and biomacromolecules.The strategies of combining coatings with substrates include physical adsorption,chemical grafting,and self-adhesion.Though the coating materials and construction methods are different,many biomedical polymer coatings have been developed to achieve excellent performances,i.e.,enhanced lubrication,anti-inflammation,antifouling,antibacterial,drug release,anti-encrustation,anti-thrombosis,etc.Consequently,a large number of biomedical polymer coatings have been used in artificial lungs,ureteral stent,vascular flow diverter,and artificial joints.In this review,we summarize different types,properties,construction methods,biological functions,and clinical applications of biomedical organic polymer coatings,and prospect future direction for development of organic polymer coatings in biomedical field.It is anticipated that this review can be useful for the design and synthesis of functional organic polymer coatings with various biomedical purposes.
基金supported by the National Basic Research Program of China (Grant No.2006CB921602)the Ministry of Education of China (Grant No.107100)the Program for New Century Excellent Talents in University and the Technology Program of Shaanxi Province (Grant No.2006K04-c25)
文摘White organic light-emitting device (WOLEDs) employing molecular mixed host (MH) is demonstrated by spin-coating.The spin-coated film functions as light-emitting layer and hole transporting layer,with the former formed by spin-coating solution containing MH of NPB (N.N'-Bis(naphthalene-1-yl)-N,N'-bis(phenyl)-benzidine) and MADN (2-methyl-9,10-di(2-naphthyl) anthracene),blue dye (4,4'-bis[2-(4-(N,N-diphenylamino)phenyl)vinyl]biphenyl) and yellow dye (5,6,11,12-tetraphenylnaphacene).The performances of the devices made with different mixed ratio of MH are investigated.It is found that the device performances depends on the MH ratio,and under the optimal NPB:MADN ratio (60:40),the WOLEDs show a maximum luminance of 24 671 cd/m2 and a current efficiency of 5.8 cd/A for the practical luminance of 1000 cd/m2.The effect of MH ratio on device performances can be attributed to the difference of hole mobility between the NPB and MADN.
基金Innovate UK:Coated current collector for battery performance improvement,Grant/Award Numbers:CONTACT,ref/10041084,2023-2025Innovate UK:Thin and lightweight current collector for lithium-ion battery,Grant/Award Numbers:CONDUCTOR,ref/10047927+3 种基金EPSRC First Grant:Energy storage electrode manufacture,Grant/Award Number:EP/P026818/1EPSRC Industrial Strategy:3D electrodes from 2D materials,Grant/Award Number:EP/R023034/1Innovate UK:Scalable electrophoretic manufacture of highdensity two-dimensional materials for energy storage applications,Grant/Award Number:ref/132508Innovate UK:Current collector for improved battery performance COATED,Grant/Award Numbers:ref/2021,2022,98297。
文摘The current collector is a crucial component in lithium-ion batteries and supercapacitor setups,responsible for gathering electrons from electrode materials and directing them into the external circuit.However,as battery systems evolve and the demand for higher energy density increases,the limitations of traditional current collectors,such as high contact resistance and low corrosion resistance,have become increasingly evident.This review investigates the functions and challenges associated with current collectors in modern battery and supercapacitor systems,with a particular focus on using carbon coating methods to enhance their performance.Surface coating,known for its simplicity and wide applicability,emerges as a promising solution to address these challenges.The review provides a comprehensive overview of carbon-coated current collectors across various types of metal and nonmetal substrates in lithium-ion batteries and supercapacitors,including a comparative analysis of coating materials and techniques.It also discusses methods for manufacturing carbon-coated current collectors and their practical implications for the industry.Furthermore,the review explores prospects and opportunities,highlighting the development of next-generation high-performance coatings and emphasizing the importance of advanced current collectors in optimizing energy device performance.
基金the funding by the ARC Research Hub for Advanced Manufacturing with 2D Materials(ARC IH210100025)。
文摘Towards the development of highly efficient electrochromic coatings,the crystallinity,morphology(e.g.size and shape)of electrochromic nanomaterials,and their charge insertion capacities play a significant role.Herein,we report the structure-dependent colouration effciency in electrochromic coatings based on the use of 0D,1D and 2D tungsten trioxide(WO_(3))nanostructures.A series of WO_(3)with different nanostructures were prepared and used as working electrodes to fabricate electrochromic devices for smart windows applications.Facile spray coating was applied on fluorine-doped tin oxide(FTO)substrate to make~70%transparent working electrodes to investigate their charge insertion capacities,electrochromic active surface area,and colouration efficiency.Results showed that the 2D WO_(3)nanoflakes displayed the highest diffusion coefficient for the intercalation of 1.52×10^(-10)cm^(2)/s with an increased electrochemical active surface area of 25.10 mF/cm^(2),a large modulation of optical reflectance(42.63%)with 3.79 s shorter response time for bleaching and a greater colouration efficiency(CE)value(89.29 cm^(2)/C)at 700 nm compared to the CE value for 1D WO_(3)(of 22 cm^(2)/C)and 0D WO_(3)(8 cm^(2)/C).The outcome of this study provides a new insight and valuable contribution to design an efficient electrochromic coating by controlling and optimising the nanostructures of selective electrochromic materials.
文摘TRISO （Tri-structural iso-tropic）-coated particle fuel is being developed to support the development of a VHTR （very high temperature reactor） in Korea. From August 2013, the first irradiation testing of coated particle fuel was begun to demonstrate and qualify TRISO fuel for use in the VHTR in HANARO （high-flux advanced neutron application reactor） at KAERI （Korea Atomic Energy Research Institute）. This experiment is currently undergoing under an atmosphere of a mixed inert gas without on-line temperature monitoring and control combined with on-line fission product monitoring of the sweep gas. The irradiation device contains two test rods, one contains nine fuel compacts and the other five compacts and eight graphite specimens. Each compact has 263 coated particles. After a peak bum-up of about 4% and a peak fast neutron fluence of about 1.7 × 1021 n/cm2, PIE （post irradiation examination） will be carried out at KAERI＇s irradiated material examination facility. This paper describes the characteristics of coated particle fuels, and the design of the test rod and irradiation device for the coated particle fuels, and discusses the technical results of irradiation testing at HANARO.
