In this paper,the host-vip interaction of cucurbit[7]uril(Q[7]) and chromone(CMO) has been developed as a fluorescent probe for the highly selective detection of Zn2+ and Cd^(2+) in water based on a chelation-enhanc...In this paper,the host-vip interaction of cucurbit[7]uril(Q[7]) and chromone(CMO) has been developed as a fluorescent probe for the highly selective detection of Zn2+ and Cd^(2+) in water based on a chelation-enhanced fluorescence(CHEF) mechanism.There was a good linear relationship between the fluorescence intensity of the CMO@Q[7] probe and the concentration of Zn^(2+ )or Cd^(2+) in the range of 0-3.0×10^(-5) mol/L and the detection limit for Zn^(2+) and Cd2+ was found to be 2.03×10^(-6) mol/L and 1.89×10^(-6)mol/L,respectively.The X-ray crystal structure indicated that different coordination fashions were triggered by Zn^(2+) and Cd^(2+ )in the CMO@Q[7] complexes,respectively.However,both metal ions coordinated with the carbonyl oxygen of CMO,which was encapsulated in the cavity of Q[7],thus leading to the enhancement of recognition fluorescence emission of CMO.展开更多
A simple ＂off-on＂ fluorescent chemosensor with high selectivity to zinc ions based on 1,10-phenanthro-line receptor dipyrido[3,2-d：2＇,3＇-f]quinoxaline（L） was investigated.The selectivity response of receptor L ...A simple ＂off-on＂ fluorescent chemosensor with high selectivity to zinc ions based on 1,10-phenanthro-line receptor dipyrido[3,2-d：2＇,3＇-f]quinoxaline（L） was investigated.The selectivity response of receptor L to zinc ion was demonstrated by UV-Vis absorption and fluorescence spectroscopies in DMF buffer solution.The experiment results show that the fluorescent chemosensor L exhibits the optimum response behavior to Zn2＋ in the range of pH 8.0―9.0 and shows excellent selectivity to Zn2＋ over other cations tested.展开更多
Solvothermal reaction of Zn(NO_(3))_(2)·6H_(2)O with di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine(ppvppa)and 1,4-naphthalenedicarboxylic acid(1,4-H_(2)NDC)in H_(2)O and MeCN at 150℃yielded a twodimens...Solvothermal reaction of Zn(NO_(3))_(2)·6H_(2)O with di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine(ppvppa)and 1,4-naphthalenedicarboxylic acid(1,4-H_(2)NDC)in H_(2)O and MeCN at 150℃yielded a twodimensional(2D)coordination Zn(Ⅱ)polymer[Zn(ppvppa)(1,4-NDC)]_(n)(1).Compound 1 was characterized by elemental analysis,IR spectroscopy,powder X-ray diffraction,single-crystal X-ray diffraction and thermogravimetric analysis.Compound 1 consists of dimeric[Zn_(2)(ppvppa)_(2)]units linked by 1,4-NDC bridges to generate a 2D honeycomb network.Either compound 1 or ppvppa alone can detect Hg^(2+)or MeHgI selectively and with good sensitivity.Upon addition of Hg^(2+)ions to a MeCN solution of ppvppa,marked changes in the UV-vis and fluorescence spectra are observed,associated with colour changes,which are easily identified by the naked eye.The pyridinyl rings of ppvppa are coordinated to the Hg^(2+)ion.This motif in the presence of NO_(3)^(−)ions forms a binuclear complex[Hg_(2)(ppvppa)_(2)(NO_(3))_(4)](2),which has been characterized as the solvate[Hg_(2)(ppvppa)_(2)(NO_(3))_(4)]·H_(2)O·4MeCN(2·H_(2)O·4MeCN)by singlecrystal X-ray diffraction studies.In aqueous solution,compound 1 emits pale orange light at ambient temperature and the addition of Hg^(2+)or MeHgI induces an change of fluorescence color from pale orange to blue.Compound 1 is a promising candidate as a sensitive naked-eye indicator for Hg^(2+)or MeHgI in water under a UV lamp.展开更多
Bimetallic MOFs show a synergistic effect and enhanced properties compared to their monometallic counterparts;however,the topologies and functions of bimetallic MOFs are difficult to predict or control.Here,a 3D metal...Bimetallic MOFs show a synergistic effect and enhanced properties compared to their monometallic counterparts;however,the topologies and functions of bimetallic MOFs are difficult to predict or control.Here,a 3D metal-organic framework(MOF),Tb-HODA,with an uncoordinated carboxyl group inner pore has been constructed,which exhibits good chemical resistance to both acidic and alkaline solutions with pH ranging from 2.5 to 12.5.Owing to the use of uncoordinated carboxyl groups within the channel as potential coordination sites for metal ions,this stable MOF exhibits a high sensitivity(KSV=5.12×10^(4) L mol^(-1))and a low detection limit(1.28 ppb)for sensing Fe^(2+)ions in aqueous solution,as well as a strong adsorption of Fe^(2+)with a potential to be a long-acting toxicide.Notably,the Lewis acidic property considerably increases when Tb-HODA adsorbs Fe^(2+)(Tb-HODA.Fe^(2+)),which makes Tb-HODA.Fe^(2+)exhibit highly efficient and selective solid acid catalysis for the dehydration of fructose/glucose into 5-hydroxymethylfurfural.展开更多
The development of novel materials with dual functions of simultaneous detection and removal of heavy metal ions has been an important pursuit of environmental remediation.Herein,we demonstrate that two-dimensional co...The development of novel materials with dual functions of simultaneous detection and removal of heavy metal ions has been an important pursuit of environmental remediation.Herein,we demonstrate that two-dimensional covalent organic frameworks(COFs)with well-defined functional chelating sites can combine the inherent advantages of COF materials to prepare novel materials with the dual functions of selective detection and effective removal of Ni^(2+)from aqueous solutions.展开更多
The development of an efficient and easy fabricated approach to detect ascorbic acid(AA)is of physiological and pathological significance.In this work,a two-photon sensor platform which is constituted with a 1,8-napht...The development of an efficient and easy fabricated approach to detect ascorbic acid(AA)is of physiological and pathological significance.In this work,a two-photon sensor platform which is constituted with a 1,8-naphthalimide-based fluorophore and CoOOH nanosheets was designed in which the blue two-photon fluorescence of the fluorophore was suppressed to a remarkable extent via a FRET process between CoOOH nanosheets and the fluorophore.The fluorescence inhibition could be removed through the specific reaction of CoOOH and AA.Based on this feature,we have demonstrated the prominent sensing performance of the sensor platform,including excellent two-photon induced fluorescence properties,a convenient fabrication pathway,a specific response to AA,a wider linear range and a high stability.This fluorescence assay is capable of detecting AA in living cells and has potential for further application such as AA associated disease diagnosis.展开更多
Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-...Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-chemical detection of various medicines. CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine （DA） and ascorbic acid （AA）, much better than those of CoPc, graphene oxide （GrO） or graphene （Gr） modified electrode. Significantly, the detection of dopamine is a diffusion-controlled process, highly selective, and has a low detection limit and broad linear range.展开更多
The aluminum based MOFs compound, MIL-96(Al), has been studied as a luminescence sensor by incorporating of Eu3+ ions, which renders the compound strong red-light emission. The as-synthesized MIL-96(Al):Eu3+ nanocryst...The aluminum based MOFs compound, MIL-96(Al), has been studied as a luminescence sensor by incorporating of Eu3+ ions, which renders the compound strong red-light emission. The as-synthesized MIL-96(Al):Eu3+ nanocrystals exhibit water dispersibility and environmental stability, which are general requirement for an ideal sensing material. The MIL-96(Al):Eu3+ nanocrystals show excellent selective detection ability on Fe3+ ions in aqueous solution with value of low detection limit 20 μM. Meanwhile, it also exhibits excellent selective detection ability on CrO42- and Cr2O72- in aqueous solution with value of low detection limit 10 and 22 μM, respectively. The results of this study show that MIL-96(Al):Eu3+ nanocrystals could be used as a multi-responsive luminescent senor for Fe3+ and Cr(Ⅵ) species in aqueous solution. The possible luminescence quenching mechanism has also been discussed.展开更多
Detection of trace-level hydrogen sulfide(H2 S)gas is of great importance whether in industrial production or disease diagnosis.This research presents a novel H2 S gas sensor based on integrated resonant dual-microcan...Detection of trace-level hydrogen sulfide(H2 S)gas is of great importance whether in industrial production or disease diagnosis.This research presents a novel H2 S gas sensor based on integrated resonant dual-microcantilevers which can identify and detect trace-level H2 S in real-time.The sensor consists of two integrated resonant microcantilever sensors with different functions.One cantilever sensor can identify H2 S by outputting positive frequency shift signals,while the other cantilever sensor will detect H2 S as a normally used cantilever sensor with negative frequency shifts.Combined the two cantilever sensors,the proposed gas sensor can distinguish H2 S from a variety of common gases,and the detection limit to H2 S of the sensor is as sensitive as below 1 ppb.展开更多
Sulfur is a soft Lewis base and thiocarbonyl has moderate electrophilicity.Our probe’s properties are adjusted in such a way that it could simultaneously detect a Lewis acid(Hg^(2+))and a strong nucleophile(NH_(2)-NH...Sulfur is a soft Lewis base and thiocarbonyl has moderate electrophilicity.Our probe’s properties are adjusted in such a way that it could simultaneously detect a Lewis acid(Hg^(2+))and a strong nucleophile(NH_(2)-NH_(2)).Considering the above fact,a thioureido-functionalized robust MOF material was prepared,which was utilized for the selective fluorometric detection of environmentally significant toxic pollutants(Hg^(2+)and NH_(2)-NH_(2))in an aqueous medium.展开更多
Nitrofuran antibiotics threaten human health and the environment due to their toxicity and persistence.Their detection is challenging due to low concentrations and interference,while fluorescence sensing offers superi...Nitrofuran antibiotics threaten human health and the environment due to their toxicity and persistence.Their detection is challenging due to low concentrations and interference,while fluorescence sensing offers superior sensitivity and selectivity for effective monitoring.In this work,a novel halogen-bonded organic framework,XOF-TPEM,was introduced,constructed using an imidazole-based ligand AIE molecule,TPEM.The framework was successfully characterized by various techniques,including 1H NMR,PXRD,XPS,FT-IR,HRTEM,SAED,SEM and EDS,confirming its excellent crystalline structure.As TPEM is an electron-donating AIE fluorophore,the fluorescent XOF-TPEM demonstrates potential as a selective sensor for electron-deficient nitrofuran antibiotics.Experimental results show that it exhibits high sensitivity and selectivity for detecting nitrofurans such as NFT,FZD,FLD,and NFZ,with LODs of 9.7 ppb,11.0 ppb,19.7 ppb,and 236.1 ppb,respectively.Mechanistic studies indicate that the outstanding fluorescence detection performance is attributed to the inner-filter effect occurring between XOF-TPEM and the nitrofuran antibiotics.Through comparison with the sensing performance of a pyridine-based XOF,the superiority of imidazole ligands in constructing XOFs is demonstrated.This study presents a novel luminescent halogen-bonded organic framework and highlights the superiority of imidazole-based halogen-bonded organic frameworks,underscoring their significant potential for expanding their functional applications.展开更多
Domesticated sheep have been exposed to artificial selection for the production of fiber, meat, and milk as well as to natural selection. Such selections are likely to have imposed distinctive selection signatures on ...Domesticated sheep have been exposed to artificial selection for the production of fiber, meat, and milk as well as to natural selection. Such selections are likely to have imposed distinctive selection signatures on the sheep genome. Therefore, detecting selection signatures across the genome may help elucidate mechanisms of selection and pinpoint candidate genes of interest for further investigation. Here, detection of selection signatures was conducted in three sheep breeds, Sunite （n=66）, German Mutton （n=159）, and Dorper （n=93）, using the Illumina OvineSNP50 Genotyping BeadChip array. Each animal provided genotype information for 43 273 autosomal single nucleotide polymorphisms （SNPs）. We adopted two complementary haplotype-based statistics of relative extended haplotype homozygosity （REHH） and the cross-popu- lation extended haplotype homozygosity （XP-EHH） tests. In total, 707,755, and 438 genomic regions subjected to positive selection were identified in Sunite, German Mutton, and Dorper sheep, respectively, and 42 of these regions were detected using both REHH and XP-EHH analyses. These genomic regions harbored many important genes, which were enriched in gene ontology terms involved in muscle development, growth, and fat metabolism. Fourteen of these genomic regions overlapped with those identified in our previous genome-wide association studies, further indicating that these genes under positive selection may underlie growth developmental traits. These findings contribute to the identification of candidate genes of interest and aid in understanding the evolutionary and biological mechanisms for controlling complex traits in Chinese and western sheep.展开更多
A novel and simple cyanide chemosensor 2-（naphthalen-1-ylmethylene）malononitrile（L） was designed and synthesized via a green chemistry method in water without using any catalyst.The chemosensor showed an excellent...A novel and simple cyanide chemosensor 2-（naphthalen-1-ylmethylene）malononitrile（L） was designed and synthesized via a green chemistry method in water without using any catalyst.The chemosensor showed an excellent sensitivity and selectivity for CN in aqueous solution.The detection limit could be as low as 1.6×10~7 moI/L（0.16μmol/L）,which is far lower than the WHO guideline of 1.9μmol/L cyanide for drink water.展开更多
The synthesis,characterisation and capability to selectively detect vapours of volatile organic compounds(VOCs)and nitroaromatic explosives of a new family of 2-dimensional rare earth(RE)MOFs based on a hexanuclear(RE...The synthesis,characterisation and capability to selectively detect vapours of volatile organic compounds(VOCs)and nitroaromatic explosives of a new family of 2-dimensional rare earth(RE)MOFs based on a hexanuclear(RE^(3+))6 secondary building unit(SBU)is reported.The reaction of RE(NO_(3))_(3)with 4,4’-sulfonyldibenzoic acid(H_(2)SDBA)in the presence of 2-fluorobenzoic acid(HFBA)in DMF/MeOH at 100℃afforded compound[RE6(μ_(3)-OH/F)_(8)(SDBA)4(NO_(3))2(H_(2)O)_(6)]_(n)(UCY-15(RE);RE:Y,Eu,Gd,Tb,Dy,Ho,Er).展开更多
A chemometric method to determine selective ion by using non-negative immune algorithm （NNIA） was proposed. In the method, the mutual projections of the chromatographic profiles at different m/z channel are calculat...A chemometric method to determine selective ion by using non-negative immune algorithm （NNIA） was proposed. In the method, the mutual projections of the chromatographic profiles at different m/z channel are calculated using NNIA. Suppose a GC-MS data with m retention time points and n mass channels, the projections of the GC-MS data onto a chromatographic profile at a mass channel will form a mass spectrum of ln vector. If the chromatographic profile at a selective mass channel is used, the extracted mass spectrum will be a correct one. Therefore, by comparing the extracted mass spectrum with a reference spectrum, the selective ion can be identified, and the corresponding chromatographic profile can be obtained at the same time. GC-MS data of 40-pesticide mixture was investigated by the method. The results show that both the mass spectral and the chromatographic information of the interested components can be extracted from the overlapping signals, except for the special cases of isomeric components with very similar mass spectra.展开更多
Non-uniform step-size distribution is implemented for split-step based nonlinear compensation in singlechannel 112-Gb/s 16 quadrature amplitude modulation （QAM） transmission. Numerical simulations of the system incl...Non-uniform step-size distribution is implemented for split-step based nonlinear compensation in singlechannel 112-Gb/s 16 quadrature amplitude modulation （QAM） transmission. Numerical simulations of the system including a 20 × 80 km uncompensated link are performed using logarithmic step size distribution to compensate signal distortions. 50% of reduction in number of steps with respect to using constant step sizes is observed. The performance is further improved by optimizing nonlinear calculating position （NLCP） in case of using constant step sizes while NLCP optimization becomes unnecessary when using logarithmic step sizes, which reduces the computational effort due to uniformly distributed nonlinear phase for all successive steps.展开更多
Depression has been closely associated with an elevated risk of myocardial infarction,yet the underlying mechanistic link remains unclear.Adenosine,a neuromodulator implicated in both depression and cardiovascular dis...Depression has been closely associated with an elevated risk of myocardial infarction,yet the underlying mechanistic link remains unclear.Adenosine,a neuromodulator implicated in both depression and cardiovascular diseases,is believed to play a critical role in this connection.Here,we present a highly sensitive adenosine-responsive nanosensor capable of in vivo imaging of adenosine levels in the brain.Using this nanosensor,we identified a marked elevation of adenosine levels in the habenula of mouse models exhibiting both depressive-like behavior and myocardial infarction.Mechanistically,we found that accumulated adenosine activates microglia,leading to the release of pro-inflammatory cytokines and subsequent neuroinflammation.This neuroinflammatory response appears to trigger peripheral inflammation,ultimately activating the JAK1-STAT1-RIPK1-caspase-8 signaling pathway in cardiomyocytes and exacerbating myocardial injury.Importantly,treatment with the antidepressant fluoxetine significantly reduced adenosine accumulation in the brain,as detected by the nanosensor,and simultaneously alleviated myocardial damage.This innovative approach to imaging adenosine in the brain offers fresh insights into the relationship between depression and myocardial infarction.展开更多
基金support from the Science and Technology Support Plan of Guizhou Province [Guizhou Science and Technology Cooperation Support (2020) 4Y218]。
文摘In this paper,the host-vip interaction of cucurbit[7]uril(Q[7]) and chromone(CMO) has been developed as a fluorescent probe for the highly selective detection of Zn2+ and Cd^(2+) in water based on a chelation-enhanced fluorescence(CHEF) mechanism.There was a good linear relationship between the fluorescence intensity of the CMO@Q[7] probe and the concentration of Zn^(2+ )or Cd^(2+) in the range of 0-3.0×10^(-5) mol/L and the detection limit for Zn^(2+) and Cd2+ was found to be 2.03×10^(-6) mol/L and 1.89×10^(-6)mol/L,respectively.The X-ray crystal structure indicated that different coordination fashions were triggered by Zn^(2+) and Cd^(2+ )in the CMO@Q[7] complexes,respectively.However,both metal ions coordinated with the carbonyl oxygen of CMO,which was encapsulated in the cavity of Q[7],thus leading to the enhancement of recognition fluorescence emission of CMO.
基金Supported by the Talent-supporting Program Foundation of Liaoning Province,China(No.2009R03)the Science Foundation of Education Office of Liaoning Province,China(No.2009A028)
文摘A simple ＂off-on＂ fluorescent chemosensor with high selectivity to zinc ions based on 1,10-phenanthro-line receptor dipyrido[3,2-d：2＇,3＇-f]quinoxaline（L） was investigated.The selectivity response of receptor L to zinc ion was demonstrated by UV-Vis absorption and fluorescence spectroscopies in DMF buffer solution.The experiment results show that the fluorescent chemosensor L exhibits the optimum response behavior to Zn2＋ in the range of pH 8.0―9.0 and shows excellent selectivity to Zn2＋ over other cations tested.
基金financial support from the National Natural Science Foundation of China(Grant No.21373142,21531006,and 21471108)State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences(2015kf-07)+3 种基金the financial support from the Qing-Lan Projectthe“333”Project of Jiangsu Provincethe Priority Academic Program Development of Jiangsu Higher Education Institutionsthe“SooChow Scholar”Program of Soochow University.
文摘Solvothermal reaction of Zn(NO_(3))_(2)·6H_(2)O with di-pyridin-2-yl-[4-(2-pyridin-4-yl-vinyl)-phenyl]-amine(ppvppa)and 1,4-naphthalenedicarboxylic acid(1,4-H_(2)NDC)in H_(2)O and MeCN at 150℃yielded a twodimensional(2D)coordination Zn(Ⅱ)polymer[Zn(ppvppa)(1,4-NDC)]_(n)(1).Compound 1 was characterized by elemental analysis,IR spectroscopy,powder X-ray diffraction,single-crystal X-ray diffraction and thermogravimetric analysis.Compound 1 consists of dimeric[Zn_(2)(ppvppa)_(2)]units linked by 1,4-NDC bridges to generate a 2D honeycomb network.Either compound 1 or ppvppa alone can detect Hg^(2+)or MeHgI selectively and with good sensitivity.Upon addition of Hg^(2+)ions to a MeCN solution of ppvppa,marked changes in the UV-vis and fluorescence spectra are observed,associated with colour changes,which are easily identified by the naked eye.The pyridinyl rings of ppvppa are coordinated to the Hg^(2+)ion.This motif in the presence of NO_(3)^(−)ions forms a binuclear complex[Hg_(2)(ppvppa)_(2)(NO_(3))_(4)](2),which has been characterized as the solvate[Hg_(2)(ppvppa)_(2)(NO_(3))_(4)]·H_(2)O·4MeCN(2·H_(2)O·4MeCN)by singlecrystal X-ray diffraction studies.In aqueous solution,compound 1 emits pale orange light at ambient temperature and the addition of Hg^(2+)or MeHgI induces an change of fluorescence color from pale orange to blue.Compound 1 is a promising candidate as a sensitive naked-eye indicator for Hg^(2+)or MeHgI in water under a UV lamp.
基金supported by the Natural Science Foundation of Jiangsu Province for Outstanding Youth(No.BK20180105)the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(TAPP),and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_2353,KYCX20_2240).
文摘Bimetallic MOFs show a synergistic effect and enhanced properties compared to their monometallic counterparts;however,the topologies and functions of bimetallic MOFs are difficult to predict or control.Here,a 3D metal-organic framework(MOF),Tb-HODA,with an uncoordinated carboxyl group inner pore has been constructed,which exhibits good chemical resistance to both acidic and alkaline solutions with pH ranging from 2.5 to 12.5.Owing to the use of uncoordinated carboxyl groups within the channel as potential coordination sites for metal ions,this stable MOF exhibits a high sensitivity(KSV=5.12×10^(4) L mol^(-1))and a low detection limit(1.28 ppb)for sensing Fe^(2+)ions in aqueous solution,as well as a strong adsorption of Fe^(2+)with a potential to be a long-acting toxicide.Notably,the Lewis acidic property considerably increases when Tb-HODA adsorbs Fe^(2+)(Tb-HODA.Fe^(2+)),which makes Tb-HODA.Fe^(2+)exhibit highly efficient and selective solid acid catalysis for the dehydration of fructose/glucose into 5-hydroxymethylfurfural.
基金financially supported by Hubei Key Laboratory of Biomass Fibers&Eco-Dyeing&Finishing(STRZ202124 and STRZ202118).
文摘The development of novel materials with dual functions of simultaneous detection and removal of heavy metal ions has been an important pursuit of environmental remediation.Herein,we demonstrate that two-dimensional covalent organic frameworks(COFs)with well-defined functional chelating sites can combine the inherent advantages of COF materials to prepare novel materials with the dual functions of selective detection and effective removal of Ni^(2+)from aqueous solutions.
文摘The development of an efficient and easy fabricated approach to detect ascorbic acid(AA)is of physiological and pathological significance.In this work,a two-photon sensor platform which is constituted with a 1,8-naphthalimide-based fluorophore and CoOOH nanosheets was designed in which the blue two-photon fluorescence of the fluorophore was suppressed to a remarkable extent via a FRET process between CoOOH nanosheets and the fluorophore.The fluorescence inhibition could be removed through the specific reaction of CoOOH and AA.Based on this feature,we have demonstrated the prominent sensing performance of the sensor platform,including excellent two-photon induced fluorescence properties,a convenient fabrication pathway,a specific response to AA,a wider linear range and a high stability.This fluorescence assay is capable of detecting AA in living cells and has potential for further application such as AA associated disease diagnosis.
基金supported by the National Natural Science Foundation of China (Grant No. 20773121 and No. 21176221)the National Basic Research in "Climbing" Program of China (Grant No. 2011CB201402)
文摘Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-chemical detection of various medicines. CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine （DA） and ascorbic acid （AA）, much better than those of CoPc, graphene oxide （GrO） or graphene （Gr） modified electrode. Significantly, the detection of dopamine is a diffusion-controlled process, highly selective, and has a low detection limit and broad linear range.
基金Supported by the Natural Science Foundation of Fujian Province (2017J01746)National Natural Science Foundation of China (51972061)。
文摘The aluminum based MOFs compound, MIL-96(Al), has been studied as a luminescence sensor by incorporating of Eu3+ ions, which renders the compound strong red-light emission. The as-synthesized MIL-96(Al):Eu3+ nanocrystals exhibit water dispersibility and environmental stability, which are general requirement for an ideal sensing material. The MIL-96(Al):Eu3+ nanocrystals show excellent selective detection ability on Fe3+ ions in aqueous solution with value of low detection limit 20 μM. Meanwhile, it also exhibits excellent selective detection ability on CrO42- and Cr2O72- in aqueous solution with value of low detection limit 10 and 22 μM, respectively. The results of this study show that MIL-96(Al):Eu3+ nanocrystals could be used as a multi-responsive luminescent senor for Fe3+ and Cr(Ⅵ) species in aqueous solution. The possible luminescence quenching mechanism has also been discussed.
基金supported by National Key R&D Program of China(No.2016YFA0200800)National Natural Science Foundation of China(NSFC,Nos.61874130,61604163,61527818,61604162)+1 种基金Key Research Program of Frontier Sciences of Chinese Academy of Sciences(No.QYZDJ-SSW-JSC001)the financial support of the Youth Innovation Promotion Association CAS(No.2017278)。
文摘Detection of trace-level hydrogen sulfide(H2 S)gas is of great importance whether in industrial production or disease diagnosis.This research presents a novel H2 S gas sensor based on integrated resonant dual-microcantilevers which can identify and detect trace-level H2 S in real-time.The sensor consists of two integrated resonant microcantilever sensors with different functions.One cantilever sensor can identify H2 S by outputting positive frequency shift signals,while the other cantilever sensor will detect H2 S as a normally used cantilever sensor with negative frequency shifts.Combined the two cantilever sensors,the proposed gas sensor can distinguish H2 S from a variety of common gases,and the detection limit to H2 S of the sensor is as sensitive as below 1 ppb.
基金support for this work was obtained from SERB through grant no.CRG/2021/000080 and EEQ/2021/000013.
文摘Sulfur is a soft Lewis base and thiocarbonyl has moderate electrophilicity.Our probe’s properties are adjusted in such a way that it could simultaneously detect a Lewis acid(Hg^(2+))and a strong nucleophile(NH_(2)-NH_(2)).Considering the above fact,a thioureido-functionalized robust MOF material was prepared,which was utilized for the selective fluorometric detection of environmentally significant toxic pollutants(Hg^(2+)and NH_(2)-NH_(2))in an aqueous medium.
基金supported by National Natural Science Foundation of China(22371218,21702153,52270070 and 21801194)Wuhan Science and Technology Bureau(whkxjsjoo9)support of the Core Facility of Wuhan University and the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University。
文摘Nitrofuran antibiotics threaten human health and the environment due to their toxicity and persistence.Their detection is challenging due to low concentrations and interference,while fluorescence sensing offers superior sensitivity and selectivity for effective monitoring.In this work,a novel halogen-bonded organic framework,XOF-TPEM,was introduced,constructed using an imidazole-based ligand AIE molecule,TPEM.The framework was successfully characterized by various techniques,including 1H NMR,PXRD,XPS,FT-IR,HRTEM,SAED,SEM and EDS,confirming its excellent crystalline structure.As TPEM is an electron-donating AIE fluorophore,the fluorescent XOF-TPEM demonstrates potential as a selective sensor for electron-deficient nitrofuran antibiotics.Experimental results show that it exhibits high sensitivity and selectivity for detecting nitrofurans such as NFT,FZD,FLD,and NFZ,with LODs of 9.7 ppb,11.0 ppb,19.7 ppb,and 236.1 ppb,respectively.Mechanistic studies indicate that the outstanding fluorescence detection performance is attributed to the inner-filter effect occurring between XOF-TPEM and the nitrofuran antibiotics.Through comparison with the sensing performance of a pyridine-based XOF,the superiority of imidazole ligands in constructing XOFs is demonstrated.This study presents a novel luminescent halogen-bonded organic framework and highlights the superiority of imidazole-based halogen-bonded organic frameworks,underscoring their significant potential for expanding their functional applications.
基金supported by the National Natural Science Foundation of China (31200927)the National Modern Agricultural Industry Technology Fund for Scientists in the Sheep Industry System of China (CARS-39-04B)the Agricultural Science and Technology Innovation Program, China (ASTIP-IAS-TS-6)
文摘Domesticated sheep have been exposed to artificial selection for the production of fiber, meat, and milk as well as to natural selection. Such selections are likely to have imposed distinctive selection signatures on the sheep genome. Therefore, detecting selection signatures across the genome may help elucidate mechanisms of selection and pinpoint candidate genes of interest for further investigation. Here, detection of selection signatures was conducted in three sheep breeds, Sunite （n=66）, German Mutton （n=159）, and Dorper （n=93）, using the Illumina OvineSNP50 Genotyping BeadChip array. Each animal provided genotype information for 43 273 autosomal single nucleotide polymorphisms （SNPs）. We adopted two complementary haplotype-based statistics of relative extended haplotype homozygosity （REHH） and the cross-popu- lation extended haplotype homozygosity （XP-EHH） tests. In total, 707,755, and 438 genomic regions subjected to positive selection were identified in Sunite, German Mutton, and Dorper sheep, respectively, and 42 of these regions were detected using both REHH and XP-EHH analyses. These genomic regions harbored many important genes, which were enriched in gene ontology terms involved in muscle development, growth, and fat metabolism. Fourteen of these genomic regions overlapped with those identified in our previous genome-wide association studies, further indicating that these genes under positive selection may underlie growth developmental traits. These findings contribute to the identification of candidate genes of interest and aid in understanding the evolutionary and biological mechanisms for controlling complex traits in Chinese and western sheep.
基金supported by the National Natural Science Foundation of China(NSFC)(Nos.21064006,21161018, 21262032)the Natural Science Foundation of Gansu Province (No.1010RJZA018)the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT1177)
文摘A novel and simple cyanide chemosensor 2-（naphthalen-1-ylmethylene）malononitrile（L） was designed and synthesized via a green chemistry method in water without using any catalyst.The chemosensor showed an excellent sensitivity and selectivity for CN in aqueous solution.The detection limit could be as low as 1.6×10~7 moI/L（0.16μmol/L）,which is far lower than the WHO guideline of 1.9μmol/L cyanide for drink water.
基金funded under the M-ERA.NET Call 2019 and the Republic of Cyprus through the Research and Innovation Foundation(contract no:P2P/M-ERA.NET/0319/0005,Acronym:SALMOS)This research has been also funded by the Spanish AEI/MCIN/10.13039/501100011033 within the NextGenerationEU/PRTR funds through the projects PCI2020-112241(M-ERA.NET 2019 project7106,SALMOS)and PID2019-110430 GB-C22(ADLIGHT)+1 种基金European Regional Development Fund(80%)and Andalusian CTEICU/JA in the framework of the Operative Programme FEDER-Andalucia 2014-2020 through projects P20_01258(objective 01)and UPO-1381028(objective 1.2.3.)also contributed to the present researchWe also thank the laboratory of materials characterization INMALAB of Universidad Pablo de Olavide for experiments and technical support.
文摘The synthesis,characterisation and capability to selectively detect vapours of volatile organic compounds(VOCs)and nitroaromatic explosives of a new family of 2-dimensional rare earth(RE)MOFs based on a hexanuclear(RE^(3+))6 secondary building unit(SBU)is reported.The reaction of RE(NO_(3))_(3)with 4,4’-sulfonyldibenzoic acid(H_(2)SDBA)in the presence of 2-fluorobenzoic acid(HFBA)in DMF/MeOH at 100℃afforded compound[RE6(μ_(3)-OH/F)_(8)(SDBA)4(NO_(3))2(H_(2)O)_(6)]_(n)(UCY-15(RE);RE:Y,Eu,Gd,Tb,Dy,Ho,Er).
基金financially supported by the National Natural Science Foundation of China (21175074)
文摘A chemometric method to determine selective ion by using non-negative immune algorithm （NNIA） was proposed. In the method, the mutual projections of the chromatographic profiles at different m/z channel are calculated using NNIA. Suppose a GC-MS data with m retention time points and n mass channels, the projections of the GC-MS data onto a chromatographic profile at a mass channel will form a mass spectrum of ln vector. If the chromatographic profile at a selective mass channel is used, the extracted mass spectrum will be a correct one. Therefore, by comparing the extracted mass spectrum with a reference spectrum, the selective ion can be identified, and the corresponding chromatographic profile can be obtained at the same time. GC-MS data of 40-pesticide mixture was investigated by the method. The results show that both the mass spectral and the chromatographic information of the interested components can be extracted from the overlapping signals, except for the special cases of isomeric components with very similar mass spectra.
基金funding of the Erlangen Graduate School in Advanced Optical Technologies (SAOT) by the German National Science Foundation(DFG) in the framework of the excellence initiative
文摘Non-uniform step-size distribution is implemented for split-step based nonlinear compensation in singlechannel 112-Gb/s 16 quadrature amplitude modulation （QAM） transmission. Numerical simulations of the system including a 20 × 80 km uncompensated link are performed using logarithmic step size distribution to compensate signal distortions. 50% of reduction in number of steps with respect to using constant step sizes is observed. The performance is further improved by optimizing nonlinear calculating position （NLCP） in case of using constant step sizes while NLCP optimization becomes unnecessary when using logarithmic step sizes, which reduces the computational effort due to uniformly distributed nonlinear phase for all successive steps.
基金supported by the National Key R&D Program of China(2023YFF1205900)the National Natural Science Foundation of China(22174038,52221001,and 22574144)+3 种基金the Hunan Provincial Key Research and Development Plan(2024JK2117)the Natural Science Foundation of Hunan Province(2025JJ20017)the Science and Technology Innovation Program of Hunan Province(2023RC3127)the New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘Depression has been closely associated with an elevated risk of myocardial infarction,yet the underlying mechanistic link remains unclear.Adenosine,a neuromodulator implicated in both depression and cardiovascular diseases,is believed to play a critical role in this connection.Here,we present a highly sensitive adenosine-responsive nanosensor capable of in vivo imaging of adenosine levels in the brain.Using this nanosensor,we identified a marked elevation of adenosine levels in the habenula of mouse models exhibiting both depressive-like behavior and myocardial infarction.Mechanistically,we found that accumulated adenosine activates microglia,leading to the release of pro-inflammatory cytokines and subsequent neuroinflammation.This neuroinflammatory response appears to trigger peripheral inflammation,ultimately activating the JAK1-STAT1-RIPK1-caspase-8 signaling pathway in cardiomyocytes and exacerbating myocardial injury.Importantly,treatment with the antidepressant fluoxetine significantly reduced adenosine accumulation in the brain,as detected by the nanosensor,and simultaneously alleviated myocardial damage.This innovative approach to imaging adenosine in the brain offers fresh insights into the relationship between depression and myocardial infarction.
