Dynamic equations of motional flexible beam elements were derived considering second-order effect. Non-linear finite element method and three-node Euler-Bernoulli beam elements were used. Because accuracy is higher in...Dynamic equations of motional flexible beam elements were derived considering second-order effect. Non-linear finite element method and three-node Euler-Bernoulli beam elements were used. Because accuracy is higher in non-linear structural analysis,three-node beam elements are used to deduce shape functions and stiffness matrices in dynamic equations of flexible elements. Static condensation method was used to obtain the finial dynamic equations of three-node beam elements. According to geometrical relations of nodal displacements in concomitant and global coordinate system,dynamic equations of elements can be transformed to global coordinate system by concomitant coordinate method in order to build the global dynamic equations. Analyzed amplitude condition of flexible arm support of a port crane,the results show that second-order effect should be considered in kinetic-elastic analysis for heavy load machinery of big flexibility.展开更多
DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expres...DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expression data generated. To address this, this paper employs a mixed-effects model to analyze gene expression data. In terms of data selection, 1176 genes from the white mouse gene expression dataset under two experimental conditions were chosen, setting up two conditions: pneumococcal infection and no infection, and constructing a mixed-effects model. After preprocessing the gene chip information, the data were imported into the model, preliminary results were calculated, and permutation tests were performed to biologically validate the preliminary results using GSEA. The final dataset consists of 20 groups of gene expression data from pneumococcal infection, which categorizes functionally related genes based on the similarity of their expression profiles, facilitating the study of genes with unknown functions.展开更多
In this paper, using finite-time control method, we consider the disturbance analysis of a second-order system with unknown but bounded disturbance. We show that the states of the second-order system will be stabilize...In this paper, using finite-time control method, we consider the disturbance analysis of a second-order system with unknown but bounded disturbance. We show that the states of the second-order system will be stabilized to a region containing the origin. The radius of this region is determined by the control parameters and can be rendered as small as desired. The rigorous stability analysis is also given. Compared with the conventional PD control law, the finite-time control law yields a better disturbance rejection performance. Numerical simulation results show the effectiveness of the method.展开更多
A full-scale research study was conducted during the bored tunnelling of the Klang Valley Mass Rapid Transit-Putrajaya Line beneath an existing building structure in Kuala Lumpur,Malaysia.The primary objective was to ...A full-scale research study was conducted during the bored tunnelling of the Klang Valley Mass Rapid Transit-Putrajaya Line beneath an existing building structure in Kuala Lumpur,Malaysia.The primary objective was to investigate the tunnel-soil-pile interaction at various stages of tunnel excavation.This study combined field measurements and three-dimensional(3D)numerical analysis to understand the transient effects of TBM tunnelling on a loaded pile.An experimental pile was instrumented with vibrating wire strain gauges,an inclinometer,and distributed fibre optic sensors using Brillouin optical time domain analysis.The pile was pre-loaded and continuously monitored in real-time throughout the tunnel construction process.The 3D finite element modelling was used to simulate the pile’s transient responses based on actual tunnel boring machine(TBM)driving data.The study revealed that the zone of influence due to tunnelling effects extended from y¼2D to y¼4D,with the peak effect observed at y¼1D to 1.5D,where D represents the tunnel diameter.The analysis of axial load patterns highlighted transient responses,including tensile loads below the tunnel invert,which propagated upward and subsided due to negative skin friction.The maximum downdrag load observed reached 56%e71%of the pile’s working load.Additionally,pile movement patterns indicated outward deflections as the TBM approached and a return toward the tunnel post-passage,aligning with the predicted behaviour in a negative face loss scenario.This validated numerical framework provides a solid foundation for further parametric studies and enhances the understanding of tunnel-soil-pile interactions.展开更多
With the evolution of society,education reform continues to progress,and increasing attention is being paid to the learning outcomes and overall academic quality of junior high school students.As a core subject at thi...With the evolution of society,education reform continues to progress,and increasing attention is being paid to the learning outcomes and overall academic quality of junior high school students.As a core subject at this stage,the effectiveness of Chinese language teaching directly influences students’overall academic performance.Therefore,enhancing the effectiveness of junior high school Chinese classroom teaching has become a key focus for educators.Against this backdrop,this paper explores the significance of building an effective classroom environment in junior high school Chinese teaching and provides an in-depth analysis of strategies to improve teaching effectiveness.The goal is to assist teachers in creating efficient classrooms,fostering students’interest in learning,enhancing their overall competence in Chinese,and ultimately improving teaching quality to contribute to the overall advancement of Chinese language education.展开更多
In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stag...In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stages seriously affects output accuracy and stability.To solve this problem,the motion characteristics of a rotating stage and the mechanism by which friction nonlinearity influences accuracy are analyzed in detail.In addition,a compound control strategy based on a kinematic model and the Stribeck friction model is designed.A friction disturbance observer based on output position feedback is improved for simple parameter tuning.Finally,an experimental system is constructed to carry out validation tests,including identification of nonlinear characteristics and performance comparisons.The experimental results show that the linear tracking error of the torque-type rotating stage is less than 1.47µm after adoption of the proposed model-based composite control strategy,and the corresponding rotary angle deviation is less than 0.0153°.The linearity of output motion is increased to 97.59%and the error compensation effect is improved by 51.6%compared with the PID control method.The experimental results confirm that the analysis method adopted here and the proposed compensation strategy can effectively reduce frictional nonlinearity and improve motion accuracy.The proposed method can also be applied to other precision electromechanical systems.展开更多
Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patien...Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1,2022 to May 31,2023 were selected as the control group.According to the equal group experiment method,80 elderly patients who were managed using FMEA from June 1,2023 to May 31,2024 were selected as the FMEA group.The control group received traditional nursing management,while the FMEA group applied FMEA to analyze failure causes,calculate Risk Priority Numbers(RPNs),identify failure modes with higher RPNs,analyze the influencing factors,develop improvement measures,and optimize processes.The RPN values and the incidence of DVT,as well as nursing satisfaction scores,were compared in the two groups.Results:Compared with the control group,the total RPN values of the FEMA group decreased significantly,with a reduction rate of 87.0%.Besides,the incidence of DVT was 1.3%in the FMEA group,lower than 10.0%in the control group(8/80).What’s more,the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group.Conclusion:The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT,lower RPN values,and improve nursing satisfaction.展开更多
With the acceleration of industrialization and urbanization,ammonia nitrogen pollution in water bodies has become increasingly severe,making the development of efficient and low-consumption wastewater treatment tech-n...With the acceleration of industrialization and urbanization,ammonia nitrogen pollution in water bodies has become increasingly severe,making the development of efficient and low-consumption wastewater treatment tech-nologies highly significant.This study employs three-dimensional computational fluid dynamics(CFD)to investigate the cavitation mechanisms and flow field characteristics in a novel jet impingement-negative pressure ammonia removal reactor.The simulation,validated by experimental pressure data with a high degree of consistency,utilizes the Mixture model,the Realizable k-εturbulence model,and the Schnerr-Sauer cavitation model.The results demonstrate that the flow velocity undergoes a substantial acceleration within the orifice nozzle,triggering a dramatic pressure drop from an inlet value of approximately 1.17 MPa to below the saturated vapor pressure,reaching as low as−109 kPa,which induces intense cavitation.Cavitation bubbles primarily originate on the inner wall of the nozzle,with the vapor volume fraction peaking at about 0.42 within the orifice.A strong positive correlation was observed between the local vapor fraction and the flow velocity,indicating that cavitation enhances jet intensity.Furthermore,vortex structures near the wall and within the jacket sustain low-pressure zones,facilitating continuous cavitation and efficient mixing.This study quantitatively elucidates the cavitation dynamics and its interplay with the flow field,providing a solid theoretical and numerical basis for optimizing the reactor design to enhance ammonia removal efficiency.展开更多
This work presents the “Second-Order Comprehensive Adjoint Sensitivity Analysis Methodology (2<sup>nd</sup>-CASAM)” for the efficient and exact computation of 1<sup>st</sup>- and 2<sup>...This work presents the “Second-Order Comprehensive Adjoint Sensitivity Analysis Methodology (2<sup>nd</sup>-CASAM)” for the efficient and exact computation of 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to uncertain parameters and domain boundaries of linear systems. The model’s response (<em>i.e.</em>, model result of interest) is a generic nonlinear function of the model’s forward and adjoint state functions, and also depends on the imprecisely known boundaries and model parameters. In the practically important particular case when the response is a scalar-valued functional of the forward and adjoint state functions characterizing a model comprising N parameters, the 2<sup>nd</sup>-CASAM requires a single large-scale computation using the First-Level Adjoint Sensitivity System (1<sup>st</sup>-LASS) for obtaining all of the first-order response sensitivities, and at most N large-scale computations using the Second-Level Adjoint Sensitivity System (2<sup>nd</sup>-LASS) for obtaining exactly all of the second-order response sensitivities. In contradistinction, forward other methods would require (<em>N</em>2/2 + 3 <em>N</em>/2) large-scale computations for obtaining all of the first- and second-order sensitivities. This work also shows that constructing and solving the 2<sup>nd</sup>-LASS requires very little additional effort beyond the construction of the 1<sup>st</sup>-LASS needed for computing the first-order sensitivities. Solving the equations underlying the 1<sup>st</sup>-LASS and 2<sup>nd</sup>-LASS requires the same computational solvers as needed for solving (<em>i.e.</em>, “inverting”) either the forward or the adjoint linear operators underlying the initial model. Therefore, the same computer software and “solvers” used for solving the original system of equations can also be used for solving the 1<sup>st</sup>-LASS and the 2<sup>nd</sup>-LASS. Since neither the 1<sup>st</sup>-LASS nor the 2<sup>nd</sup>-LASS involves any differentials of the operators underlying the original system, the 1<sup>st</sup>-LASS is designated as a “<u>first-level</u>” (as opposed to a “first-order”) adjoint sensitivity system, while the 2<sup>nd</sup>-LASS is designated as a “<u>second-level</u>” (rather than a “second-order”) adjoint sensitivity system. Mixed second-order response sensitivities involving boundary parameters may arise from all source terms of the 2<sup>nd</sup>-LASS that involve the imprecisely known boundary parameters. Notably, the 2<sup>nd</sup>-LASS encompasses an automatic, inherent, and independent “solution verification” mechanism of the correctness and accuracy of the 2nd-level adjoint functions needed for the efficient and exact computation of the second-order sensitivities.展开更多
An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characteriz...An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in vivo.Although the analytes spectra substantially overlapped with that of the biological matrix,the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region selection.The proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time intervals.In addition,several statistical parameters were employed to evaluate the accuracy and precision of the method.Quantitative results were confirmed by HPLC-mass spectrometry.Satisfactory results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo.展开更多
Huang-Lian-Jie-Du-Decoction （HLJDD） has been widely used for the treatment of Alzheimer＇s disease （AD） in clinic. However, the relationship between its chemical profile and neuroprotective bioactivity was not cle...Huang-Lian-Jie-Du-Decoction （HLJDD） has been widely used for the treatment of Alzheimer＇s disease （AD） in clinic. However, the relationship between its chemical profile and neuroprotective bioactivity was not clearly clarified yet. In present study, the water extract of HLJDD and subsequent three polarity fractions divided by different reagents were investigated. A total of 17 chromatographic peaks were confirmed by comparison with standards and their UV, MS spectra. Among them, 11 major compounds were determined by HPLC-DAD method with good linear regression relationship （r2, 0.9994-0.9999）, precisions （inter-day precision RSD, 0.79%-1.07%; intra-day precision RSD, 1.59%-2.10%）, repeatability （RSD, 1.66%-3.67%）, stability （RSD, 1.26%-4.77%） and recovery （95.24%-105.41%, RSD, 0.29%-2.69%）. Furthermore, PC12 cells and primary neurons cells were used for the neuroprotective effective assessment of aforementioned four samples from HLJDD. 3＂he total aqueous extract and n-butanol extract of HLJDD presented more significant effects than the other two parts. According to their quality and quantity determination results, iridoids and alkaloids have a positive correlation with the neuroprotective effectiveness of HLJDD.展开更多
Plant height is one of the important agronomic traits of rice. Over higher plant would easily result in plant lodging and output reducing. On the other hand, the dwarf varieties with proper plant height had higher lod...Plant height is one of the important agronomic traits of rice. Over higher plant would easily result in plant lodging and output reducing. On the other hand, the dwarf varieties with proper plant height had higher lodging resistance and a greater harvest index, allowing for the increased use of nitrogen fertilizer. Dwarf breeding had made a great breakthrough in the rice breeding. The breeding and extension of excellent dwarf varieties remarkably improved the yield potential of rice. Therefore, the plant height is still one of the focuses in rice genetic research.展开更多
To discuss the relationship between stability and bullwhip effect in the supply chain system,a basic model in a production-inventory control system is developed using difference equations.Z-transform techniques are ap...To discuss the relationship between stability and bullwhip effect in the supply chain system,a basic model in a production-inventory control system is developed using difference equations.Z-transform techniques are applied to investigate the production ordering and inventory dynamics.For the two operational regimes of sufficient inventory coverage and insufficient inventory coverage,the scope of decision parameters which make the system stable or instable is investigated.Under two operational regimes and the actual system,production release rates,stability/instability and bullwhip effect in the stable region and instable region are examined based on different demand functions,and then the numerical simulation results are given.The results show that reasonable choices of fractional adjustment of inventory and supply line can make the system stable and decrease bullwhip effect.It is summarized that the piecewise linearization based on the stability analysis approach is a valid approximation to the analysis of production-inventory ordering systems with nonlinearities.Some interesting results are obtained and they have important implications for improving inventory and order decisions in supply chain systems.展开更多
We propose an improved statistical approach for modeling interconnect slew that takes into account the scattering effect of a nanoscale wire. We first propose a simple, closed-form scattering effect resistivity model,...We propose an improved statistical approach for modeling interconnect slew that takes into account the scattering effect of a nanoscale wire. We first propose a simple, closed-form scattering effect resistivity model, considering the effects of both width and thickness. Then we use this model to derive statistical expressions of the slew metrics using the SS2M model. We find that the delay and slew can be greatly increased when considering the scattering effect. The proposed statistical SS2M model has an average error of 4.16% with respect to SPICE Monte Carlo simulations, with an average error of standard deviation of only 3.06%.展开更多
Based on the schema theory,the paper analyzes the psychological cognitive process of listening comprehension.Schema theory provides a good theoretical basis to improve the English listening teaching effectiveness.Prac...Based on the schema theory,the paper analyzes the psychological cognitive process of listening comprehension.Schema theory provides a good theoretical basis to improve the English listening teaching effectiveness.Practice shows that the schema theory application to guide teaching practice can achieve great progress in an English listening classroom.展开更多
To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weap...To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weapon systems by combining grey relational analysis and TOPSIS is proposed. The model aggregates the grey relational grade and the distance to a new integrated closeness and reflects not only the trend but also the situation of the alternative. The example illuminates that the model is effective for the effectiveness evaluation of weapon systems.展开更多
Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China....Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China. However, the development of mega-urban agglomerations has triggered the interactive coercion between resources and the eco-envi- ronment. The interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations represent frontier and high-priority research topics in the field of Earth system science over the next decade. In this paper, we carried out systematic theo- retical analysis of the interactive coupling mechanisms and coercing effects between ur- banization and the eco-environment in mega-urban agglomerations. In detail, we analyzed the nonlinear-coupled relationships and the coupling characteristics between natural and human elements in mega-urban agglomerations. We also investigated the interactive coercion intensities between internal and external elements, and the mechanisms and patterns of local couplings and telecouplings in mega-urban agglomeration systems, which are affected by key internal and external control elements. In addition, we proposed the interactive coupling theory on urbanization and the eco-environment in mega-urban agglomerations. Furthermore we established a spatiotemporal dynamic coupling model with multi-element, multi-scale, multi-scenario, multi-module and multi-agent integrations, which can be used to develop an intelligent decision support system for sustainable development of mega-urban agglomera- tions. In general, our research may provide theoretical guidance and method support to solve problems related to mega-urban agglomerations and maintain their sustainable development.展开更多
A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication pr...A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation（SOR） iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.展开更多
Long steel piles with large diameters have been more widely used in the field of ocean engineering. Owing to the pile with a large diameter, soil plug development during pile driving has great influences on pile drive...Long steel piles with large diameters have been more widely used in the field of ocean engineering. Owing to the pile with a large diameter, soil plug development during pile driving has great influences on pile driveability and bearing capacity. The response of soil plug developed inside the open-ended pipe pile during the dynamic condition of pile-driving is different from the response under the static condition of loading during service. This paper addresses the former aspect. A numerical procedure for soil plug effect prediction and pile driveabihty analysis is proposed and described. By taking into consideration of the pile dimension effect on side and tip resistance, this approach introduces a dimensional coefficient to the conventional static eqnihbrium equations for the plug differential unit and proposes an improved static equity method for the plug effect prediction. At the same time, this approach introduces a simplified model by use of one-dimensional stress wave equation to simulate the interaction between soil plug and pile inner wall. The proposed approach has been applied in practical engineering analyses. Results show that the calculated plug effect and pile driveabihty based on the proposed approach agree well with the observed data.展开更多
BACKGROUND Craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar injuries.Recently,the incidence of craniocerebral injuries has increased dramatically due to the inc...BACKGROUND Craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar injuries.Recently,the incidence of craniocerebral injuries has increased dramatically due to the increased numbers of traffic accidents and aerial work injuries,threatening the physical and mental health of patients.AIM To investigate the impact of failure modes and effects analysis(FMEA)-based emergency management on craniocerebral injury treatment effectiveness.METHODS Eighty-four patients with craniocerebral injuries,treated at our hospital from November 2019 to March 2021,were selected and assigned,using the random number table method,to study(n=42)and control(n=42)groups.Patients in the control group received conventional management while those in the study group received FMEA theory-based emergency management,based on the control group.Pre-and post-interventions,details regarding the emergency situation;levels of inflammatory stress indicators[Interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT)];incidence of complications;prognoses;and satisfaction regarding patient care were evaluated for both groups.RESULTS For the study group,the assessed parameters[pre-hospital emergency response time(9.13±2.37 min),time to receive a consultation(2.39±0.44 min),time needed to report imaging findings(1.15±4.44 min),and test reporting time(32.19±6.23 min)]were shorter than those for the control group(12.78±4.06 min,3.58±0.71 min,33.49±5.51 min,50.41±11.45 min,respectively;P<0.05).Pre-intervention serum levels of IL-6(78.71±27.59 pg/mL),CRP(19.80±6.77 mg/L),and PCT(3.66±1.82 ng/mL)in the study group patients were not significantly different from those in the control group patients(81.31±32.11 pg/mL,21.29±8.02 mg/L,and 3.95±2.11 ng/mL respectively;P>0.05);post-intervention serum indicator levels were lower in both groups than pre-intervention levels.Further,serum levels of IL-6(17.35±5.33 pg/mL),CRP(2.27±0.56 mg/L),and PCT(0.22±0.07 ng/mL)were lower in the study group than in the control group(30.15±12.38 pg/mL,3.13±0.77 mg/L,0.38±0.12 ng/mL,respectively;P<0.05).The complication rate observed in the study group(9.52%)was lower than that in the control group(26.19%,P<0.05).The prognoses for the study group patients were better than those for the control patients(P<0.05).Patient care satisfaction was higher in the study group(95.24%)than in the control group(78.57%,P<0.05).CONCLUSION FMEA-based craniocerebral injury management effectively shortens the time spent on emergency care,reduces inflammatory stress and complication risk levels,and helps improve patient prognoses,while achieving high patient care satisfaction levels.展开更多
文摘Dynamic equations of motional flexible beam elements were derived considering second-order effect. Non-linear finite element method and three-node Euler-Bernoulli beam elements were used. Because accuracy is higher in non-linear structural analysis,three-node beam elements are used to deduce shape functions and stiffness matrices in dynamic equations of flexible elements. Static condensation method was used to obtain the finial dynamic equations of three-node beam elements. According to geometrical relations of nodal displacements in concomitant and global coordinate system,dynamic equations of elements can be transformed to global coordinate system by concomitant coordinate method in order to build the global dynamic equations. Analyzed amplitude condition of flexible arm support of a port crane,the results show that second-order effect should be considered in kinetic-elastic analysis for heavy load machinery of big flexibility.
文摘DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expression data generated. To address this, this paper employs a mixed-effects model to analyze gene expression data. In terms of data selection, 1176 genes from the white mouse gene expression dataset under two experimental conditions were chosen, setting up two conditions: pneumococcal infection and no infection, and constructing a mixed-effects model. After preprocessing the gene chip information, the data were imported into the model, preliminary results were calculated, and permutation tests were performed to biologically validate the preliminary results using GSEA. The final dataset consists of 20 groups of gene expression data from pneumococcal infection, which categorizes functionally related genes based on the similarity of their expression profiles, facilitating the study of genes with unknown functions.
基金supported by National Natural Science Foundation of China (No.60504007)the PhD Programs Foundation of Ministry of Educationof China (No.20070286040)the Scientific Research Foundation of Graduate School of Southeast University
文摘In this paper, using finite-time control method, we consider the disturbance analysis of a second-order system with unknown but bounded disturbance. We show that the states of the second-order system will be stabilized to a region containing the origin. The radius of this region is determined by the control parameters and can be rendered as small as desired. The rigorous stability analysis is also given. Compared with the conventional PD control law, the finite-time control law yields a better disturbance rejection performance. Numerical simulation results show the effectiveness of the method.
文摘A full-scale research study was conducted during the bored tunnelling of the Klang Valley Mass Rapid Transit-Putrajaya Line beneath an existing building structure in Kuala Lumpur,Malaysia.The primary objective was to investigate the tunnel-soil-pile interaction at various stages of tunnel excavation.This study combined field measurements and three-dimensional(3D)numerical analysis to understand the transient effects of TBM tunnelling on a loaded pile.An experimental pile was instrumented with vibrating wire strain gauges,an inclinometer,and distributed fibre optic sensors using Brillouin optical time domain analysis.The pile was pre-loaded and continuously monitored in real-time throughout the tunnel construction process.The 3D finite element modelling was used to simulate the pile’s transient responses based on actual tunnel boring machine(TBM)driving data.The study revealed that the zone of influence due to tunnelling effects extended from y¼2D to y¼4D,with the peak effect observed at y¼1D to 1.5D,where D represents the tunnel diameter.The analysis of axial load patterns highlighted transient responses,including tensile loads below the tunnel invert,which propagated upward and subsided due to negative skin friction.The maximum downdrag load observed reached 56%e71%of the pile’s working load.Additionally,pile movement patterns indicated outward deflections as the TBM approached and a return toward the tunnel post-passage,aligning with the predicted behaviour in a negative face loss scenario.This validated numerical framework provides a solid foundation for further parametric studies and enhances the understanding of tunnel-soil-pile interactions.
文摘With the evolution of society,education reform continues to progress,and increasing attention is being paid to the learning outcomes and overall academic quality of junior high school students.As a core subject at this stage,the effectiveness of Chinese language teaching directly influences students’overall academic performance.Therefore,enhancing the effectiveness of junior high school Chinese classroom teaching has become a key focus for educators.Against this backdrop,this paper explores the significance of building an effective classroom environment in junior high school Chinese teaching and provides an in-depth analysis of strategies to improve teaching effectiveness.The goal is to assist teachers in creating efficient classrooms,fostering students’interest in learning,enhancing their overall competence in Chinese,and ultimately improving teaching quality to contribute to the overall advancement of Chinese language education.
基金funded by the European Union’s Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant Agreement(Grant No.101026104)by the National Natural Science Foundation of China(Grant No.U20A6004)in part by the State Key Laboratory of Precision Electronics Manufacturing Technology and Equipment(Grant No.JMDZ202314).
文摘In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stages seriously affects output accuracy and stability.To solve this problem,the motion characteristics of a rotating stage and the mechanism by which friction nonlinearity influences accuracy are analyzed in detail.In addition,a compound control strategy based on a kinematic model and the Stribeck friction model is designed.A friction disturbance observer based on output position feedback is improved for simple parameter tuning.Finally,an experimental system is constructed to carry out validation tests,including identification of nonlinear characteristics and performance comparisons.The experimental results show that the linear tracking error of the torque-type rotating stage is less than 1.47µm after adoption of the proposed model-based composite control strategy,and the corresponding rotary angle deviation is less than 0.0153°.The linearity of output motion is increased to 97.59%and the error compensation effect is improved by 51.6%compared with the PID control method.The experimental results confirm that the analysis method adopted here and the proposed compensation strategy can effectively reduce frictional nonlinearity and improve motion accuracy.The proposed method can also be applied to other precision electromechanical systems.
文摘Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1,2022 to May 31,2023 were selected as the control group.According to the equal group experiment method,80 elderly patients who were managed using FMEA from June 1,2023 to May 31,2024 were selected as the FMEA group.The control group received traditional nursing management,while the FMEA group applied FMEA to analyze failure causes,calculate Risk Priority Numbers(RPNs),identify failure modes with higher RPNs,analyze the influencing factors,develop improvement measures,and optimize processes.The RPN values and the incidence of DVT,as well as nursing satisfaction scores,were compared in the two groups.Results:Compared with the control group,the total RPN values of the FEMA group decreased significantly,with a reduction rate of 87.0%.Besides,the incidence of DVT was 1.3%in the FMEA group,lower than 10.0%in the control group(8/80).What’s more,the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group.Conclusion:The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT,lower RPN values,and improve nursing satisfaction.
基金supported by Chongqing Natural Science Foundation Innovation and Development Joint Fund(CSTB2023NSCQ-LZX0095)Chongqing Natural Science Foundation General Project(CSTB2025NSCQ-GPX0955)+3 种基金Science and Technology Research Program of Chongqing Municipal Education Commission of China(KJQN202401157)The Open and Innovation Fund of Hubei Three Gorges Laboratory(SK250005)The Key Laboratory of Manufacturing and Application of Intelligent Well Control for Oil and Gas Production and Transportation of Luzhou(2024LZOGB-05)postgraduate Innovation Project of Chongqing University of Technology(CYS240709).
文摘With the acceleration of industrialization and urbanization,ammonia nitrogen pollution in water bodies has become increasingly severe,making the development of efficient and low-consumption wastewater treatment tech-nologies highly significant.This study employs three-dimensional computational fluid dynamics(CFD)to investigate the cavitation mechanisms and flow field characteristics in a novel jet impingement-negative pressure ammonia removal reactor.The simulation,validated by experimental pressure data with a high degree of consistency,utilizes the Mixture model,the Realizable k-εturbulence model,and the Schnerr-Sauer cavitation model.The results demonstrate that the flow velocity undergoes a substantial acceleration within the orifice nozzle,triggering a dramatic pressure drop from an inlet value of approximately 1.17 MPa to below the saturated vapor pressure,reaching as low as−109 kPa,which induces intense cavitation.Cavitation bubbles primarily originate on the inner wall of the nozzle,with the vapor volume fraction peaking at about 0.42 within the orifice.A strong positive correlation was observed between the local vapor fraction and the flow velocity,indicating that cavitation enhances jet intensity.Furthermore,vortex structures near the wall and within the jacket sustain low-pressure zones,facilitating continuous cavitation and efficient mixing.This study quantitatively elucidates the cavitation dynamics and its interplay with the flow field,providing a solid theoretical and numerical basis for optimizing the reactor design to enhance ammonia removal efficiency.
文摘This work presents the “Second-Order Comprehensive Adjoint Sensitivity Analysis Methodology (2<sup>nd</sup>-CASAM)” for the efficient and exact computation of 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to uncertain parameters and domain boundaries of linear systems. The model’s response (<em>i.e.</em>, model result of interest) is a generic nonlinear function of the model’s forward and adjoint state functions, and also depends on the imprecisely known boundaries and model parameters. In the practically important particular case when the response is a scalar-valued functional of the forward and adjoint state functions characterizing a model comprising N parameters, the 2<sup>nd</sup>-CASAM requires a single large-scale computation using the First-Level Adjoint Sensitivity System (1<sup>st</sup>-LASS) for obtaining all of the first-order response sensitivities, and at most N large-scale computations using the Second-Level Adjoint Sensitivity System (2<sup>nd</sup>-LASS) for obtaining exactly all of the second-order response sensitivities. In contradistinction, forward other methods would require (<em>N</em>2/2 + 3 <em>N</em>/2) large-scale computations for obtaining all of the first- and second-order sensitivities. This work also shows that constructing and solving the 2<sup>nd</sup>-LASS requires very little additional effort beyond the construction of the 1<sup>st</sup>-LASS needed for computing the first-order sensitivities. Solving the equations underlying the 1<sup>st</sup>-LASS and 2<sup>nd</sup>-LASS requires the same computational solvers as needed for solving (<em>i.e.</em>, “inverting”) either the forward or the adjoint linear operators underlying the initial model. Therefore, the same computer software and “solvers” used for solving the original system of equations can also be used for solving the 1<sup>st</sup>-LASS and the 2<sup>nd</sup>-LASS. Since neither the 1<sup>st</sup>-LASS nor the 2<sup>nd</sup>-LASS involves any differentials of the operators underlying the original system, the 1<sup>st</sup>-LASS is designated as a “<u>first-level</u>” (as opposed to a “first-order”) adjoint sensitivity system, while the 2<sup>nd</sup>-LASS is designated as a “<u>second-level</u>” (rather than a “second-order”) adjoint sensitivity system. Mixed second-order response sensitivities involving boundary parameters may arise from all source terms of the 2<sup>nd</sup>-LASS that involve the imprecisely known boundary parameters. Notably, the 2<sup>nd</sup>-LASS encompasses an automatic, inherent, and independent “solution verification” mechanism of the correctness and accuracy of the 2nd-level adjoint functions needed for the efficient and exact computation of the second-order sensitivities.
基金support from the National Natural Science Foundation of China(Grants Nos.21776321,21576297,21205145,21575039)Key Projects of Technological Innovation of Hubei Province(2016ACA138)The Open Research Program(Grant Nos.2015ZD001,2015ZD002 and 2015ZY006)。
文摘An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in vivo.Although the analytes spectra substantially overlapped with that of the biological matrix,the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region selection.The proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time intervals.In addition,several statistical parameters were employed to evaluate the accuracy and precision of the method.Quantitative results were confirmed by HPLC-mass spectrometry.Satisfactory results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo.
基金Key Projects in the National Science & Technology Pillar Program during the 11thFive-Year Plan Period (Grant No.2008BAI51B02)National Natural Science Fund Project of China (Grant No. 81202904)
文摘Huang-Lian-Jie-Du-Decoction （HLJDD） has been widely used for the treatment of Alzheimer＇s disease （AD） in clinic. However, the relationship between its chemical profile and neuroprotective bioactivity was not clearly clarified yet. In present study, the water extract of HLJDD and subsequent three polarity fractions divided by different reagents were investigated. A total of 17 chromatographic peaks were confirmed by comparison with standards and their UV, MS spectra. Among them, 11 major compounds were determined by HPLC-DAD method with good linear regression relationship （r2, 0.9994-0.9999）, precisions （inter-day precision RSD, 0.79%-1.07%; intra-day precision RSD, 1.59%-2.10%）, repeatability （RSD, 1.66%-3.67%）, stability （RSD, 1.26%-4.77%） and recovery （95.24%-105.41%, RSD, 0.29%-2.69%）. Furthermore, PC12 cells and primary neurons cells were used for the neuroprotective effective assessment of aforementioned four samples from HLJDD. 3＂he total aqueous extract and n-butanol extract of HLJDD presented more significant effects than the other two parts. According to their quality and quantity determination results, iridoids and alkaloids have a positive correlation with the neuroprotective effectiveness of HLJDD.
文摘Plant height is one of the important agronomic traits of rice. Over higher plant would easily result in plant lodging and output reducing. On the other hand, the dwarf varieties with proper plant height had higher lodging resistance and a greater harvest index, allowing for the increased use of nitrogen fertilizer. Dwarf breeding had made a great breakthrough in the rice breeding. The breeding and extension of excellent dwarf varieties remarkably improved the yield potential of rice. Therefore, the plant height is still one of the focuses in rice genetic research.
文摘To discuss the relationship between stability and bullwhip effect in the supply chain system,a basic model in a production-inventory control system is developed using difference equations.Z-transform techniques are applied to investigate the production ordering and inventory dynamics.For the two operational regimes of sufficient inventory coverage and insufficient inventory coverage,the scope of decision parameters which make the system stable or instable is investigated.Under two operational regimes and the actual system,production release rates,stability/instability and bullwhip effect in the stable region and instable region are examined based on different demand functions,and then the numerical simulation results are given.The results show that reasonable choices of fractional adjustment of inventory and supply line can make the system stable and decrease bullwhip effect.It is summarized that the piecewise linearization based on the stability analysis approach is a valid approximation to the analysis of production-inventory ordering systems with nonlinearities.Some interesting results are obtained and they have important implications for improving inventory and order decisions in supply chain systems.
基金Project supported by the National Natural Science Foundation of China(No.90307017)
文摘We propose an improved statistical approach for modeling interconnect slew that takes into account the scattering effect of a nanoscale wire. We first propose a simple, closed-form scattering effect resistivity model, considering the effects of both width and thickness. Then we use this model to derive statistical expressions of the slew metrics using the SS2M model. We find that the delay and slew can be greatly increased when considering the scattering effect. The proposed statistical SS2M model has an average error of 4.16% with respect to SPICE Monte Carlo simulations, with an average error of standard deviation of only 3.06%.
文摘Based on the schema theory,the paper analyzes the psychological cognitive process of listening comprehension.Schema theory provides a good theoretical basis to improve the English listening teaching effectiveness.Practice shows that the schema theory application to guide teaching practice can achieve great progress in an English listening classroom.
文摘To evaluate the effectiveness of weapon systems, the advantages and disadvantages of grey relational analysis and TOPSIS for multiattribute decision-making is pointed out, and an effectiveness evaluation model of weapon systems by combining grey relational analysis and TOPSIS is proposed. The model aggregates the grey relational grade and the distance to a new integrated closeness and reflects not only the trend but also the situation of the alternative. The example illuminates that the model is effective for the effectiveness evaluation of weapon systems.
基金The Major Program of National Natural Science Foundation of China, No.41590840, No.41590842
文摘Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China. However, the development of mega-urban agglomerations has triggered the interactive coercion between resources and the eco-envi- ronment. The interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations represent frontier and high-priority research topics in the field of Earth system science over the next decade. In this paper, we carried out systematic theo- retical analysis of the interactive coupling mechanisms and coercing effects between ur- banization and the eco-environment in mega-urban agglomerations. In detail, we analyzed the nonlinear-coupled relationships and the coupling characteristics between natural and human elements in mega-urban agglomerations. We also investigated the interactive coercion intensities between internal and external elements, and the mechanisms and patterns of local couplings and telecouplings in mega-urban agglomeration systems, which are affected by key internal and external control elements. In addition, we proposed the interactive coupling theory on urbanization and the eco-environment in mega-urban agglomerations. Furthermore we established a spatiotemporal dynamic coupling model with multi-element, multi-scale, multi-scenario, multi-module and multi-agent integrations, which can be used to develop an intelligent decision support system for sustainable development of mega-urban agglomera- tions. In general, our research may provide theoretical guidance and method support to solve problems related to mega-urban agglomerations and maintain their sustainable development.
基金supported by Scientific Research Foundation for Returned Scholars of Ministry of Education of China
文摘A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation（SOR） iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime.
基金supported by the National Natural Science Foundation of China (Grant No.50309009)the National High Technology Research and Development Program of China(863 Program,Grant No.2004AA616100)
文摘Long steel piles with large diameters have been more widely used in the field of ocean engineering. Owing to the pile with a large diameter, soil plug development during pile driving has great influences on pile driveability and bearing capacity. The response of soil plug developed inside the open-ended pipe pile during the dynamic condition of pile-driving is different from the response under the static condition of loading during service. This paper addresses the former aspect. A numerical procedure for soil plug effect prediction and pile driveabihty analysis is proposed and described. By taking into consideration of the pile dimension effect on side and tip resistance, this approach introduces a dimensional coefficient to the conventional static eqnihbrium equations for the plug differential unit and proposes an improved static equity method for the plug effect prediction. At the same time, this approach introduces a simplified model by use of one-dimensional stress wave equation to simulate the interaction between soil plug and pile inner wall. The proposed approach has been applied in practical engineering analyses. Results show that the calculated plug effect and pile driveabihty based on the proposed approach agree well with the observed data.
基金Supported by Basic Research on Medical and Health Application of the People's Livelihood Science and Technology Project of Suzhou Science and Technology Bureau,No.SYS2020102.
文摘BACKGROUND Craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar injuries.Recently,the incidence of craniocerebral injuries has increased dramatically due to the increased numbers of traffic accidents and aerial work injuries,threatening the physical and mental health of patients.AIM To investigate the impact of failure modes and effects analysis(FMEA)-based emergency management on craniocerebral injury treatment effectiveness.METHODS Eighty-four patients with craniocerebral injuries,treated at our hospital from November 2019 to March 2021,were selected and assigned,using the random number table method,to study(n=42)and control(n=42)groups.Patients in the control group received conventional management while those in the study group received FMEA theory-based emergency management,based on the control group.Pre-and post-interventions,details regarding the emergency situation;levels of inflammatory stress indicators[Interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT)];incidence of complications;prognoses;and satisfaction regarding patient care were evaluated for both groups.RESULTS For the study group,the assessed parameters[pre-hospital emergency response time(9.13±2.37 min),time to receive a consultation(2.39±0.44 min),time needed to report imaging findings(1.15±4.44 min),and test reporting time(32.19±6.23 min)]were shorter than those for the control group(12.78±4.06 min,3.58±0.71 min,33.49±5.51 min,50.41±11.45 min,respectively;P<0.05).Pre-intervention serum levels of IL-6(78.71±27.59 pg/mL),CRP(19.80±6.77 mg/L),and PCT(3.66±1.82 ng/mL)in the study group patients were not significantly different from those in the control group patients(81.31±32.11 pg/mL,21.29±8.02 mg/L,and 3.95±2.11 ng/mL respectively;P>0.05);post-intervention serum indicator levels were lower in both groups than pre-intervention levels.Further,serum levels of IL-6(17.35±5.33 pg/mL),CRP(2.27±0.56 mg/L),and PCT(0.22±0.07 ng/mL)were lower in the study group than in the control group(30.15±12.38 pg/mL,3.13±0.77 mg/L,0.38±0.12 ng/mL,respectively;P<0.05).The complication rate observed in the study group(9.52%)was lower than that in the control group(26.19%,P<0.05).The prognoses for the study group patients were better than those for the control patients(P<0.05).Patient care satisfaction was higher in the study group(95.24%)than in the control group(78.57%,P<0.05).CONCLUSION FMEA-based craniocerebral injury management effectively shortens the time spent on emergency care,reduces inflammatory stress and complication risk levels,and helps improve patient prognoses,while achieving high patient care satisfaction levels.
