Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery ...Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.展开更多
Run-off-road crashes in the United States have become a major cause of serious injuries and fatalities. A significant portion of run-off-road crashes are single vehicle crashes that occur due to collisions with fixed ...Run-off-road crashes in the United States have become a major cause of serious injuries and fatalities. A significant portion of run-off-road crashes are single vehicle crashes that occur due to collisions with fixed objects and overturning. These crashes typically tend to be more severe than other types of crashes. Single vehicle run-off-road crashes that occurred between 2004 and 2008 were extracted from Kansas Accident Reporting System (KARS) database to identify the important factors that affected their severity. Different driver, vehicle, road, crash, and environment related factors that influence crash severity are identified by using binary logit models. Three models were developed to take different levels of crash severity as the response variables. The first model taking fatal or incapacitating crashes as the response variable seems to better fit the data than the other two developed models. The variables that were found to increase the probability of run-off-road crash severity are driver related factors such as driver ejection, being an older driver, alcohol involvement, license state, driver being at fault, medical condition of the driver;road related factors such as speed, asphalt road surface, dry road condition;time related factors such as crashes occurring between 6 pm and midnight;environment related factors such as daylight;vehicle related factors such as being an SUV, motorcycles, vehicle getting destroyed or disabled, vehicle maneuver being straight or passing;and fixed object types such as trees and ditches.展开更多
The gear transmission system directly affects the operational performance of high-speed trains(HST).However,current research on gear transmission systems of HST often overlooks the effects of gear eccentricity and run...The gear transmission system directly affects the operational performance of high-speed trains(HST).However,current research on gear transmission systems of HST often overlooks the effects of gear eccentricity and running resistance,and the dynamic models of gear transmission system are not sufficiently comprehensive.This paper aims to establish an electromechanical coupling dynamic model of HST traction transmission system and study its electromechanical coupling vibration characteristics,in which the internal excitation factors such as gear eccentricity,time-varying meshing stiffness,backlash,meshing error,and external excitation factors such as electromagnetic torque and running resistance are stressed.The research results indicate that gear eccentricity and running resistance have a significant impact on the stability of the system,and gear eccentricity leads to intensified system vibration and decreased anti-interference ability.In addition,the characteristic frequency of gear eccentricity can be extracted from mechanical signals and current signals as a preliminary basis for eccentricity detection,and electrical signals can also be used to monitor changes in train running resistance in real time.The results of this study provide some useful insights into designing dynamic performance parameters for HST transmission systems and monitoring train operational states.展开更多
Urban environments offer a wealth of opportunities for residents to respite from their hectic life.Outdoor running or jogging becomes increasingly popular of an option.Impacts of urban environments on outdoor running,...Urban environments offer a wealth of opportunities for residents to respite from their hectic life.Outdoor running or jogging becomes increasingly popular of an option.Impacts of urban environments on outdoor running,despite some initial studies,remain underexplored.This study aims to establish an analytical framework that can holistically assess the urban environment on the healthy vitality of running.The proposed framework is applied to two modern Chinese cities,i.e.,Guangzhou and Shenzhen.We construct three interpretable random forest models to explore the non-linear relationship between environmental variables and running intensity(RI)through analyzing the runners'trajectories and integrating with multi-source urban big data(e.g.,street view imagery,remote sensing,and socio-economic data)across the built,natural,and social dimensions,The findings uncover that road density has the greatest impact on RI,and social variables(e.g.,population density and housing price)and natural variables(e.g.,slope and humidity)all make notable impact on outdoor running.Despite these findings,the impact of environmental variables likely change across different regions due to disparate regional construction and micro-environments,and those specific impacts as well as optimal thresholds also alter.Therefore,construction of healthy cities should take the whole urban environment into account and adapt to local conditions.This study provides a comprehensive evaluation on the influencing variables of healthy vitality and guides sustainable urban planning for creating running-friendly cities.展开更多
Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,C...Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,CINAHL,and Web of Science were systematically searched for this meta-analysis.Crossover studies comparing the effects of running shoe LBS and/or midsole energy return on at least 1 of the following outcomes:running economy,ankle plantarflexion moment,work,power,or angular velocity were included.Results Of the 2453 studies screened,48 were included(n=878).Results indicated that advanced footwear technologies(AFTs)significantly reduced oxygen consumption(standardized mean difference=–0.44,95%confidence interval:–0.60 to–0.28),p<0.001)as well as peak ankle moments and positive/negative ankle work and power.However,neither LBS nor midsole energy return alone significantly affected oxygen consumption,ankle moments,positive and negative work,or positive power.The effects of AFTs were moderated by the training status and speed of the runner.The quality of evidence for all outcomes were low or very low for all outcomes except the effect of LBS on negative ankle work.Conclusion AFT may improve running economy by minimizing ankle moments,work,and power.The absence of significant independent effects of LBS and midsole energy return suggests that the benefits of AFTs arise from the interaction of these properties.Further research is necessary to understand the mechanisms for improved running performance in AFTs.展开更多
Ye Wei's New Year was quite lit erally off to a running start.The 35-year old,who works at a state owned enterprise in Xiamen,southeast China's Fujian Province,came 12th among Chinese runners at the 2019 Xia m...Ye Wei's New Year was quite lit erally off to a running start.The 35-year old,who works at a state owned enterprise in Xiamen,southeast China's Fujian Province,came 12th among Chinese runners at the 2019 Xia men Marathon on January 6,clocking his personal best time of 2 hours 29 minutes. It Showed how much his physical fitness has improved.The first time he took p a:rt in 2003.he couldn't even finish the marathon.展开更多
Objectives:The aim of this study was to compare the measured physiological factors that limit running performance with real marathon results from world-class distance runners,evaluating the compatibility between measu...Objectives:The aim of this study was to compare the measured physiological factors that limit running performance with real marathon results from world-class distance runners,evaluating the compatibility between measured data and predicted results based on the previously suggested model.Methods:Four world-class East African marathon runners(three male,one female)underwent physiological running assessments to predict marathon performance times using a model based on˙V O_(2)peak,percentage of˙V O_(2)peak at the second ventilatory threshold,and running economy.Predictions were then compared to participants’best marathon times.Results:The measured˙V O_(2)peak of the world-class runners was 75.1±2.7 mL/kg/min.The second ventilatory threshold occurred at 85±3%of the peak,with a running economy of 63.7±2.4 mL/kg/min at 19.6±0.9 km/h.The predicted marathon performance time was 2:06:51±0:03:17 h:min:s for the males and 2:17:36 h:min:s for the female.Comparing these predictions to their personal best times,the average difference was 00:55±00:51 min:s(range:00:20-02:08).Conclusions:This research provides laboratory data on world-class road running athletes,reinforcing the link between marathon performance and˙V O_(2)peak,the percentage of˙VO_(2)peak at the second ventilatory threshold,and running economy.The examined athletes had lower˙V O_(2)peak compared to predicted values,highlighting the importance of running economy and fractional utilization of˙V O_(2)peak in achieving such performances.Future studies should continue to advance the field by including additional bioenergetic parameters measured during race conditions and expanding the participant cohort of elite marathoners,encompassing both sexes.展开更多
BACKGROUND Wound management is an essential part of emergency medicine practice.A good suture technique should deal a complex irregular traumatic wound without any complications of dehiscence/gaping,infection,delayed ...BACKGROUND Wound management is an essential part of emergency medicine practice.A good suture technique should deal a complex irregular traumatic wound without any complications of dehiscence/gaping,infection,delayed wound healing,frequent dressings and further stay in hospital.There is no ideal technique of suturing for any wound.In pursuit of the new techniques,we have introduced a new suturing technique called combined oblique and vertical everting running(COVER)stitch which has showed good healing with less complications.AIM To compare the outcomes between the COVER stitch and conventional suturing group.METHODS In this study,we included 40 cases which were divided into two groups.Group 1 patients were managed by COVER stitch,and group 2 patients underwent conventional suturing for their wounds.The outcomes were measured in terms of scar quality,suturing duration and length of suture material used,suturing related complications and suture removal time which were compared by t-test usingχ^(2) test.RESULTS Better results were seen in COVER stitch than the conventional suturing.COVER group had significantly better results in terms of time taken for suture,amount suture material used and time taken for suture removal compared to the conventional group.No wound related complications were seen in this group.Moreover,scar formed was also better in COVER group.CONCLUSION COVER stitch is another new technique which can be used to deal simple to complex wounds and it is an emerging idea with good healthy scars with less complications.展开更多
This study investigated the validity and sensitivity of a custom-made shoelace tensile testing system.The aim was to analyze the distribution pattern of shoelace tension in different positions and under different tigh...This study investigated the validity and sensitivity of a custom-made shoelace tensile testing system.The aim was to analyze the distribution pattern of shoelace tension in different positions and under different tightness levels during running.Mechanical tests were conducted using 16 weights,and various statistical analyses,including linear regression,Bland-Altman plots,coefficient of variation,and intraclass correlation coefficient,were performed to assess the system’s validity.Fifteen male amateur runners participated in the study,and three conditions(loose,comfortable,and tight)were measured during an upright stance.The system utilized VICON motion systems,a Kistler force plate,and a Photoelectric gate speed measurement system.Results showed a linear relationship between voltage and load at the three sensors(R2≥0.9997).Bland-Altman plots demonstrated 95%prediction intervals within±1.96SD from zero for all sensors.The average coefficient of variation for each sensor was less than 0.38%.Intraclass correlation coefficient values were larger than 0.999(p<0.0001)for each sensor.The peak tension of the front shoelace was greater than that of the front and middle when the shoelace was loose and tight.The rear shoelace had the highest tension force.The study also found that shoelace tension varied throughout the gait cycle during running.Overall,this research provides a novel and validated method for measuring shoelace tensile stress,which has implications for developing automatic shoelace fastening systems.展开更多
This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is ...This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is an autoregressive model of order p,representing a time series with dependencies on its p previous values.Additionally,the study evaluates the accuracy of both explicit and numerical integral equation(NIE)solutions for AR(p)using the TEWMA control chart,focusing on the absolute percentage relative error.The results indicate that the explicit and approximate solutions are in close agreement.Furthermore,the study investigates the performance of exponentially weighted moving average(EWMA)and TEWMA control charts in detecting changes in the process,using the relative mean index(RMI)as a measure.The findings demonstrate that the TEWMA control chart outperforms the EWMA control chart in detecting process changes,especially when the value ofλis sufficiently large.In addition,an analysis using historical data from the SET index between January 2024 and May 2024 and historical data of global annual plastic production,the results of both data sets also emphasize the superior performance of the TEWMA control chart.展开更多
A real-life milk run system designing problem of an engine manufacturer adopted JIT(just-in-time)production is studied.In the process of milk run system planning and design,the supply base is identified and a supplier...A real-life milk run system designing problem of an engine manufacturer adopted JIT(just-in-time)production is studied.In the process of milk run system planning and design,the supply base is identified and a supplier site map is plotted for an arrangement of routes on which parts are periodically collected in a JIT manner from many scattered suppliers.With unit load designing,vehicle choosing and fleet sizing,pickup routing,vehicle assigning and scheduling problems are studied.Among these problems,a CVRP problem is identified and formulated as the key optimization in designing this milk run system,and it is solved through an optimization process.This tactical planning and optimization process gives a good solution to the real problem,and may shed light on the planning of similar systems.展开更多
基金supported by the NIH (R01NS103481, R01NS111776, and R01NS131489)Indiana Department of Health (ISDH58180)(all to WW)。
文摘Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.
文摘Run-off-road crashes in the United States have become a major cause of serious injuries and fatalities. A significant portion of run-off-road crashes are single vehicle crashes that occur due to collisions with fixed objects and overturning. These crashes typically tend to be more severe than other types of crashes. Single vehicle run-off-road crashes that occurred between 2004 and 2008 were extracted from Kansas Accident Reporting System (KARS) database to identify the important factors that affected their severity. Different driver, vehicle, road, crash, and environment related factors that influence crash severity are identified by using binary logit models. Three models were developed to take different levels of crash severity as the response variables. The first model taking fatal or incapacitating crashes as the response variable seems to better fit the data than the other two developed models. The variables that were found to increase the probability of run-off-road crash severity are driver related factors such as driver ejection, being an older driver, alcohol involvement, license state, driver being at fault, medical condition of the driver;road related factors such as speed, asphalt road surface, dry road condition;time related factors such as crashes occurring between 6 pm and midnight;environment related factors such as daylight;vehicle related factors such as being an SUV, motorcycles, vehicle getting destroyed or disabled, vehicle maneuver being straight or passing;and fixed object types such as trees and ditches.
基金supported by Sichuan Science and Technology Program(Grant No.2020YFH0080)the National Natural Science Foundation of China(Grant No.51475386)the National Basic Research Project of China(973 Program,Grant No.2015CB654801).
文摘The gear transmission system directly affects the operational performance of high-speed trains(HST).However,current research on gear transmission systems of HST often overlooks the effects of gear eccentricity and running resistance,and the dynamic models of gear transmission system are not sufficiently comprehensive.This paper aims to establish an electromechanical coupling dynamic model of HST traction transmission system and study its electromechanical coupling vibration characteristics,in which the internal excitation factors such as gear eccentricity,time-varying meshing stiffness,backlash,meshing error,and external excitation factors such as electromagnetic torque and running resistance are stressed.The research results indicate that gear eccentricity and running resistance have a significant impact on the stability of the system,and gear eccentricity leads to intensified system vibration and decreased anti-interference ability.In addition,the characteristic frequency of gear eccentricity can be extracted from mechanical signals and current signals as a preliminary basis for eccentricity detection,and electrical signals can also be used to monitor changes in train running resistance in real time.The results of this study provide some useful insights into designing dynamic performance parameters for HST transmission systems and monitoring train operational states.
基金National Natural Science Foundation of China,No.42171455The Hong Kong RGC Research Impact Fund,No.R5011-23The Hong Kong General Research Fund,No.15204121。
文摘Urban environments offer a wealth of opportunities for residents to respite from their hectic life.Outdoor running or jogging becomes increasingly popular of an option.Impacts of urban environments on outdoor running,despite some initial studies,remain underexplored.This study aims to establish an analytical framework that can holistically assess the urban environment on the healthy vitality of running.The proposed framework is applied to two modern Chinese cities,i.e.,Guangzhou and Shenzhen.We construct three interpretable random forest models to explore the non-linear relationship between environmental variables and running intensity(RI)through analyzing the runners'trajectories and integrating with multi-source urban big data(e.g.,street view imagery,remote sensing,and socio-economic data)across the built,natural,and social dimensions,The findings uncover that road density has the greatest impact on RI,and social variables(e.g.,population density and housing price)and natural variables(e.g.,slope and humidity)all make notable impact on outdoor running.Despite these findings,the impact of environmental variables likely change across different regions due to disparate regional construction and micro-environments,and those specific impacts as well as optimal thresholds also alter.Therefore,construction of healthy cities should take the whole urban environment into account and adapt to local conditions.This study provides a comprehensive evaluation on the influencing variables of healthy vitality and guides sustainable urban planning for creating running-friendly cities.
基金supported by a National Health and Medical Research Council(NHMRC)Investigator Grant Emerging Leadership Level 1(Grant No.2017012).
文摘Purpose We aimed to investigate the effects of running shoe longitudinal bending stiffness(LBS)and midsole energy return on running economy and ankle mechanics and energetics.Methods PubMed,Scopus,SPORTDiscus,Embase,CINAHL,and Web of Science were systematically searched for this meta-analysis.Crossover studies comparing the effects of running shoe LBS and/or midsole energy return on at least 1 of the following outcomes:running economy,ankle plantarflexion moment,work,power,or angular velocity were included.Results Of the 2453 studies screened,48 were included(n=878).Results indicated that advanced footwear technologies(AFTs)significantly reduced oxygen consumption(standardized mean difference=–0.44,95%confidence interval:–0.60 to–0.28),p<0.001)as well as peak ankle moments and positive/negative ankle work and power.However,neither LBS nor midsole energy return alone significantly affected oxygen consumption,ankle moments,positive and negative work,or positive power.The effects of AFTs were moderated by the training status and speed of the runner.The quality of evidence for all outcomes were low or very low for all outcomes except the effect of LBS on negative ankle work.Conclusion AFT may improve running economy by minimizing ankle moments,work,and power.The absence of significant independent effects of LBS and midsole energy return suggests that the benefits of AFTs arise from the interaction of these properties.Further research is necessary to understand the mechanisms for improved running performance in AFTs.
文摘Ye Wei's New Year was quite lit erally off to a running start.The 35-year old,who works at a state owned enterprise in Xiamen,southeast China's Fujian Province,came 12th among Chinese runners at the 2019 Xia men Marathon on January 6,clocking his personal best time of 2 hours 29 minutes. It Showed how much his physical fitness has improved.The first time he took p a:rt in 2003.he couldn't even finish the marathon.
基金supported by adidas AG.MJ was not compensated for his contribution to this work.
文摘Objectives:The aim of this study was to compare the measured physiological factors that limit running performance with real marathon results from world-class distance runners,evaluating the compatibility between measured data and predicted results based on the previously suggested model.Methods:Four world-class East African marathon runners(three male,one female)underwent physiological running assessments to predict marathon performance times using a model based on˙V O_(2)peak,percentage of˙V O_(2)peak at the second ventilatory threshold,and running economy.Predictions were then compared to participants’best marathon times.Results:The measured˙V O_(2)peak of the world-class runners was 75.1±2.7 mL/kg/min.The second ventilatory threshold occurred at 85±3%of the peak,with a running economy of 63.7±2.4 mL/kg/min at 19.6±0.9 km/h.The predicted marathon performance time was 2:06:51±0:03:17 h:min:s for the males and 2:17:36 h:min:s for the female.Comparing these predictions to their personal best times,the average difference was 00:55±00:51 min:s(range:00:20-02:08).Conclusions:This research provides laboratory data on world-class road running athletes,reinforcing the link between marathon performance and˙V O_(2)peak,the percentage of˙VO_(2)peak at the second ventilatory threshold,and running economy.The examined athletes had lower˙V O_(2)peak compared to predicted values,highlighting the importance of running economy and fractional utilization of˙V O_(2)peak in achieving such performances.Future studies should continue to advance the field by including additional bioenergetic parameters measured during race conditions and expanding the participant cohort of elite marathoners,encompassing both sexes.
文摘BACKGROUND Wound management is an essential part of emergency medicine practice.A good suture technique should deal a complex irregular traumatic wound without any complications of dehiscence/gaping,infection,delayed wound healing,frequent dressings and further stay in hospital.There is no ideal technique of suturing for any wound.In pursuit of the new techniques,we have introduced a new suturing technique called combined oblique and vertical everting running(COVER)stitch which has showed good healing with less complications.AIM To compare the outcomes between the COVER stitch and conventional suturing group.METHODS In this study,we included 40 cases which were divided into two groups.Group 1 patients were managed by COVER stitch,and group 2 patients underwent conventional suturing for their wounds.The outcomes were measured in terms of scar quality,suturing duration and length of suture material used,suturing related complications and suture removal time which were compared by t-test usingχ^(2) test.RESULTS Better results were seen in COVER stitch than the conventional suturing.COVER group had significantly better results in terms of time taken for suture,amount suture material used and time taken for suture removal compared to the conventional group.No wound related complications were seen in this group.Moreover,scar formed was also better in COVER group.CONCLUSION COVER stitch is another new technique which can be used to deal simple to complex wounds and it is an emerging idea with good healthy scars with less complications.
文摘This study investigated the validity and sensitivity of a custom-made shoelace tensile testing system.The aim was to analyze the distribution pattern of shoelace tension in different positions and under different tightness levels during running.Mechanical tests were conducted using 16 weights,and various statistical analyses,including linear regression,Bland-Altman plots,coefficient of variation,and intraclass correlation coefficient,were performed to assess the system’s validity.Fifteen male amateur runners participated in the study,and three conditions(loose,comfortable,and tight)were measured during an upright stance.The system utilized VICON motion systems,a Kistler force plate,and a Photoelectric gate speed measurement system.Results showed a linear relationship between voltage and load at the three sensors(R2≥0.9997).Bland-Altman plots demonstrated 95%prediction intervals within±1.96SD from zero for all sensors.The average coefficient of variation for each sensor was less than 0.38%.Intraclass correlation coefficient values were larger than 0.999(p<0.0001)for each sensor.The peak tension of the front shoelace was greater than that of the front and middle when the shoelace was loose and tight.The rear shoelace had the highest tension force.The study also found that shoelace tension varied throughout the gait cycle during running.Overall,this research provides a novel and validated method for measuring shoelace tensile stress,which has implications for developing automatic shoelace fastening systems.
基金the National Science,Research and Innovation Fund(NSRF)King Mongkuts University of Technology North Bangkok under contract no.KMUTNB-FF-68-B-08.
文摘This study aims to examine the explicit solution for calculating the Average Run Length(ARL)on the triple exponentially weighted moving average(TEWMA)control chart applied to autoregressive model(AR(p)),where AR(p)is an autoregressive model of order p,representing a time series with dependencies on its p previous values.Additionally,the study evaluates the accuracy of both explicit and numerical integral equation(NIE)solutions for AR(p)using the TEWMA control chart,focusing on the absolute percentage relative error.The results indicate that the explicit and approximate solutions are in close agreement.Furthermore,the study investigates the performance of exponentially weighted moving average(EWMA)and TEWMA control charts in detecting changes in the process,using the relative mean index(RMI)as a measure.The findings demonstrate that the TEWMA control chart outperforms the EWMA control chart in detecting process changes,especially when the value ofλis sufficiently large.In addition,an analysis using historical data from the SET index between January 2024 and May 2024 and historical data of global annual plastic production,the results of both data sets also emphasize the superior performance of the TEWMA control chart.
基金The National Key Technology R&D Program of China during the 11th Five-Year Plan Period(No.2006BAH02A06)
文摘A real-life milk run system designing problem of an engine manufacturer adopted JIT(just-in-time)production is studied.In the process of milk run system planning and design,the supply base is identified and a supplier site map is plotted for an arrangement of routes on which parts are periodically collected in a JIT manner from many scattered suppliers.With unit load designing,vehicle choosing and fleet sizing,pickup routing,vehicle assigning and scheduling problems are studied.Among these problems,a CVRP problem is identified and formulated as the key optimization in designing this milk run system,and it is solved through an optimization process.This tactical planning and optimization process gives a good solution to the real problem,and may shed light on the planning of similar systems.
