Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC...Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability.展开更多
The roughness of the fracture surface directly affects the strength,deformation,and permeability of the surrounding rock in deep underground engineering.Understanding the effect of high temperature and thermal cycle o...The roughness of the fracture surface directly affects the strength,deformation,and permeability of the surrounding rock in deep underground engineering.Understanding the effect of high temperature and thermal cycle on the fracture surface roughness plays an important role in estimating the damage degree and stability of deep rock mass.In this paper,the variations of fracture surface roughness of granite after different heating and thermal cycles were investigated using the joint roughness coefficient method(JRC),three-dimensional(3D)roughness parameters,and fractal dimension(D),and the mechanism of damage and deterioration of granite were revealed.The experimental results show an increase in the roughness of the granite fracture surface as temperature and cycle number were incremented.The variations of JRC,height parameter,inclination parameter and area parameter with the temperature conformed to the Boltzmann's functional distribution,while the D decreased linearly as the temperature increased.Besides,the anisotropy index(Ip)of the granite fracture surface increased as the temperature increased,and the larger parameter values of roughness characterization at different temperatures were attained mainly in directions of 20°–40°,60°–100°and 140°–160°.The fracture aperture of granite after fracture followed the Gauss distribution and the average aperture increased with increasing temperature,which increased from 0.665 mm at 25℃to 1.058 mm at 800℃.High temperature caused an uneven thermal expansion,water evaporation,and oxidation of minerals within the granite,which promoted the growth and expansion of microfractures,and reduced interparticle bonding strength.In particular,the damage was exacerbated by the expansion and cracking of the quartz phase transition after T>500℃.Thermal cycles contributed to the accumulation of this damage and further weakened the interparticle bonding forces,resulting in a significant increase in the roughness,anisotropy,and aperture of the fracture surface after five cycles.展开更多
Let Ω be homogeneous of degree zero,integrable on S^(n−1) and have mean value zero,T_(Ω) be the homogeneous singular integral operator with kernel Ω(x)/|x|^(n) and[b,T_(Ω)]be the commutator of T_(Ω)with symbol b∈BMO(...Let Ω be homogeneous of degree zero,integrable on S^(n−1) and have mean value zero,T_(Ω) be the homogeneous singular integral operator with kernel Ω(x)/|x|^(n) and[b,T_(Ω)]be the commutator of T_(Ω)with symbol b∈BMO(R^(n)).In this paper,the authors prove that if sup ζ∈S^(n−1)∫Sn−1^(|Ω(θ)|log^(β)(1/|θ·ζ|)dθ<∞ with β>2,then[b,T_(Ω)]is bounded on Triebel–Lizorkin space F^(0,q)p(R^(n))provided that 1+1/β−1<p,q<β.展开更多
Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road...Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road surface roughness and is a critical input to asset management. In Indiana, the IRI statistic contributes to roughly half of the pavement quality index computation used for asset management. Most agencies inventory IRI once a year, however, pavement conditions vary much more frequently. The objective of this paper is to develop a framework using crowdsourced connected vehicle data to identify and detect temporal changes in IRI. Over 3 billion connected vehicle records in Indiana were analyzed across 30 months between 2022 and 2024 to understand the spatiotemporal variations in roughness. Annual comparisons across all major interstates in Indiana showed the miles of interstates classified as “Good” decreased from 1896 to 1661 miles between 2022 and 2024. The miles of interstate classified as “Needs Maintenance” increased from 82 to 120 miles. A detailed case study showing monthly and daily changes of estimated IRI on I-65 are presented along with supporting dashcam images. Although the crowdsourced IRI estimates are not as robust as traditional specialized pavement profilers, they can be obtained on a monthly, weekly, or even daily basis. The paper concludes by suggesting a combination of frequent crowdsourced IRI and commercially available dashcam imagery of roadway can provide an agile and responsive mechanism for agencies to implement pavement asset management programs that can complement existing annual programs.展开更多
LetΩbe homogeneous of degree zero,integrable on S^(d−1) and have vanishing moment of order one,a be a function on R^(d) such that ∇a∈L^(∞)(R^(d)).Let T*_(Ω,a) be the maximaloperator associated with the d-dimensional...LetΩbe homogeneous of degree zero,integrable on S^(d−1) and have vanishing moment of order one,a be a function on R^(d) such that ∇a∈L^(∞)(R^(d)).Let T*_(Ω,a) be the maximaloperator associated with the d-dimensional Calder´on commutator defined by T*_(Ωa)f(x):=sup_(ε>0)|∫_(|x-y|>ε)^Ω(x-y)/|x-y|^(d+1)(a(x)-a(y))f(y)dy.In this paper,the authors establish bilinear sparse domination for T*_(Ω,a) under the assumption Ω∈L∞(Sd−1).As applications,some quantitative weighted bounds for T*_(Ω,a) are obtained.展开更多
Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ...Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.展开更多
As the dominant seepage channel in rock masses,it is of great significance to study the influence of fracture roughness distribution on seepage and heat transfer in rock masses.In this paper,the fracture roughness dis...As the dominant seepage channel in rock masses,it is of great significance to study the influence of fracture roughness distribution on seepage and heat transfer in rock masses.In this paper,the fracture roughness distribution functions of the Bakhtiary dam site and Oskarshamn/Forsmark mountain were fitted using statistical methods.The COMSOL Multiphysics finite element software was utilized to analyze the effects of fracture roughness distribution types and empirical formulas for fracture hydraulic aperture on the seepage field and temperature field of rock masses.The results show that:(1)The fracture roughness at the Bakhtiary dam site and Oskarshamn/Forsmark mountain follows lognormal and normal distributions,respectively;(2)For rock masses with the same expected value and standard deviation of fracture roughness,the outflow from rock masses with lognormal distribution of fracture roughness is significantly larger than that of rock masses with normal distribution of fracture roughness;(3)The fracture hydraulic aperture,outflow,and cold front distance of the Li and Jiang model are significantly larger than those of the Barton model;(4)The outflow,hydraulic pressure distribution,and temperature distribution of the Barton model are more sensitive to the fracture roughness distribution type than those of the Li and Jiang model.展开更多
BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs...BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs)often overlook age,sex,and demographic variations.Partitioned RIs,while considering these factors,fail to capture the gradual age-related physiological changes.Next-generation RIs offer a solution to this limitation.AIM To investigate age-and sex-specific dynamics of PG and establish next-generation RIs for adults and the elderly in northern China.METHODS After screening,708 healthy individuals were included in this observational study.Serum PG was measured using chemiluminescence immunoassay.Age-and sex-related effects on PG were analyzed with a two-way analysis of variance.RI partitioning was determined by the standard deviation ratio(SDR).Traditional RIs were established using a non-parametric approach.Generalized Additive Models for Location,Scale,and Shape(GAMLSS)modeled age-related trends and continuous reference percentiles for PG I and PG II.Reference limit flagging rates for both RI types were compared.RESULTS PG I and PG II levels were influenced by age(P<0.001)and sex(P<0.001),while PGR remained stable.Age-specific RIs were required for PG I(SDR=0.366)and PG II(SDR=0.424).Partitioned RIs were established for PG I and PG II,with a single RI for PGR.GAMLSS modeling revealed distinct age-dependent trajectories:PG I increased from a median of 39.75μg/L at age 20 years to 49.75μg/L at age 60 years,a 25.16%increase,after which it plateaued through age 80 years.In contrast,PG II showed a continuous rise throughout the age range,with the median value increasing from 5.07μg/L at age 20 years to 8.36μg/L at age 80 years,corresponding to a 64.89%increase.Continuous reference percentiles intuitively reflected these trends and were detailed in this study.Next-generation RIs demonstrated superior accuracy compared to partitioned RIs when applied to specific age subgroups.CONCLUSION This study elucidates the age-and sex-specific dynamics of PG and,to our knowledge,is the first to establish next-generation RIs for PG,supporting more individualized interpretation in laboratory medicine.展开更多
The distribution of Seidel eigenvalues of cographs is investigated in this paper.We prove that there is no Seidel eigenvalue of nontrivial cographs in the interval(−1,1).We also show the optimality of the interval(−1,...The distribution of Seidel eigenvalues of cographs is investigated in this paper.We prove that there is no Seidel eigenvalue of nontrivial cographs in the interval(−1,1).We also show the optimality of the interval(−1,1)in the sense that for any ε>0 either of the intervals(1,1+ε)and(−1−ε,−1)contains a Seidel eigenvalue of some cograph of order n when n is sufficiently large.展开更多
To tackle the difficulties of the point prediction in quantifying the reliability of landslide displacement prediction,a data-driven combination-interval prediction method(CIPM)based on copula and variational-mode-dec...To tackle the difficulties of the point prediction in quantifying the reliability of landslide displacement prediction,a data-driven combination-interval prediction method(CIPM)based on copula and variational-mode-decomposition associated with kernel-based-extreme-learningmachine optimized by the whale optimization algorithm(VMD-WOA-KELM)is proposed in this paper.Firstly,the displacement is decomposed by VMD to three IMF components and a residual component of different fluctuation characteristics.The key impact factors of each IMF component are selected according to Copula model,and the corresponding WOA-KELM is established to conduct point prediction.Subsequently,the parametric method(PM)and non-parametric method(NPM)are used to estimate the prediction error probability density distribution(PDF)of each component,whose prediction interval(PI)under the 95%confidence level is also obtained.By means of the differential evolution algorithm(DE),a weighted combination model based on the PIs is built to construct the combination-interval(CI).Finally,the CIs of each component are added to generate the total PI.A comparative case study shows that the CIPM performs better in constructing landslide displacement PI with high performance.展开更多
Objectives:This study aimed to explore the perceptions and recommendations of multiparas and health-related professionals regarding appropriate birth intervals(Bis)and key determinants.Methods:In-depth semi-structured...Objectives:This study aimed to explore the perceptions and recommendations of multiparas and health-related professionals regarding appropriate birth intervals(Bis)and key determinants.Methods:In-depth semi-structured interviews were conducted between April 1 and June 30,2022.Nine multiparas and thirteen health-related professionals were purposefully sampled until data saturation was reached.A thematic analysis approach was applied to the interview transcripts,utilizing dual independent coding and consensus validation in NVivo 12.0.Results:The data generated two overarching categories:1)balanced decision-making on the appropriate birth intervals and 2)internal and external determinants integrated with health and societal considerations.Four key themes emerged following the two categories:1)consistency and discrepancy between the actual and recommended birth intervals of multiparas;2)health-and developmentoriented professional recommendations;3)internal determinants related to individual-level factors;and 4)external determinants related to child-related factors,family support,and social security.Weighing women's reproductive health and career development,multiparas and health-related professionals perceived a length between 18 and 36 months as the appropriate Bl.Conclusion:Multiparas and health-related professionals shaped their balanced recommendations on a relatively appropriate birth interval ranging from 18 to 36 months,which was influenced by women's individual-level factors,child-related factors,family support,and social security.Targeted social and healthcare services should be offered to women and their families during the Bls.展开更多
Purpose We aimed to determine:(a)the chronic effects of interval training(IT)combined with blood flow restriction(BFR)on physiological adaptations(aerobic/anaerobic capacity and muscle responses)and performance enhanc...Purpose We aimed to determine:(a)the chronic effects of interval training(IT)combined with blood flow restriction(BFR)on physiological adaptations(aerobic/anaerobic capacity and muscle responses)and performance enhancement(endurance and sprints),and(b)the influence of participant characteristics and intervention protocols on these effects.Methods Searches were conducted in PubMed,Web of Science(Core Collection),Cochrane Library(Embase,ClinicalTrials.gov,and International Clinical Trials Registry Platform),and Chinese National Knowledge Infrastructure on April 2,with updates on October 17,2024.Pooled effects for each outcome were summarized using Hedge's g(g)through meta-analysis-based random effects models,and subgroup and regression analyses were used to explore moderators.Results A total of 24 studies with 621 participants were included.IT combined with BFR(IT+BFR)significantly improved maximal oxygen uptake(VO2_(max))(g=0.63,I^(2)=63%),mean power during the Wingate 30-s test(g=0.70,I^(2)=47%),muscle strength(g=0.88,I^(2)=64%),muscle endurance(g=0.43,I^(2)=0%),time to fatigue(g=1.26,I^(2)=86%),and maximal aerobic speed(g=0.74,I^(2)=0%)compared to IT alone.Subgroup analysis indicated that participant characteristics including training status,IT intensity,and IT modes significantly moderated VO2_(max)(subgroup differences:p<0.05).Specifically,IT+BFR showed significantly superior improvements in VO2_(max)compared to IT alone in trained individuals(g=0.76)at supra-maximal intensity(g=1.29)and moderate intensity(g=1.08)as well as in walking(g=1.64)and running(g=0.63)modes.Meta-regression analysis showed cuff width(β=0.14)was significantly associated with VO2_(max)change,identifying 8.23 cm as the minimum threshold required for significant improvement.Subgroup analyses regarding muscle strength did not reveal any significant moderators.Conclusion IT+BFR enhances physiological adaptations and optimizes aspects of endurance performance,with moderators including training status,IT protocol(intensity,mode,and type),and cuff width.This intervention addresses various IT-related challenges and provides tailored protocols and benefits for diverse populations.展开更多
In the present paper,we obtain the converse results of approximation of a newly introduced genuine Bernstein-Durrmeyer operators in movable interval.We also get the moments properties of an auxiliary operator which ha...In the present paper,we obtain the converse results of approximation of a newly introduced genuine Bernstein-Durrmeyer operators in movable interval.We also get the moments properties of an auxiliary operator which has its own independent values.The moments of the auxiliary operators play important roles in establishing the main result(Theorem 4).展开更多
Sapphire hemispherical domes are machined through milling and shaping using brazed diamond tools.A mathematical model describing roughness for this processing method is established,and the relationship between roughne...Sapphire hemispherical domes are machined through milling and shaping using brazed diamond tools.A mathematical model describing roughness for this processing method is established,and the relationship between roughness and its influencing factors is analyzed.Experiments on the hemispherical dome shaping process are conducted to validate the model,analyzing the variation in roughness under different tool and workpiece rotational speeds.The results are consistent with the predictions of the established roughness model,suggesting that the model can be used to guide subsequent process experiments.Milling and shaping efficiency using brazed diamond tools typically can reach 14 g/min.The machined sapphire surfaces exhibit relatively few microcracks and minimal damage,with almost all exclusively visible grooves resulting from brittle fracture removal.The surface roughness after machining is below 2.5μm.Milling sapphire domes with brazed diamond tools represents a novel shaping technique characterized by high efficiency and high quality.展开更多
High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence ...High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence to analyze mechanisms of HIIT in neuromuscular activation,hormonal responses,muscle fiber adaptation,and metabolic pathway effects.It focuses on its effectiveness in enhancing explosive power,maximum strength,and strength endurance,while also examining the integration of HIIT with traditional resistance training,periodized programming,and personalized prescription.Scientific implementation of HIIT can effectively diversify or even replace conventional strength training,not only offering positive directional changes for strength development but also introducing innovative approaches to sports performance training practices.展开更多
This paper presents the dynamical properties of a discrete-time prey-predator model with refuge in prey under imprecise biological parameters.We consider the refuge concept of prey,which is proportional to the density...This paper presents the dynamical properties of a discrete-time prey-predator model with refuge in prey under imprecise biological parameters.We consider the refuge concept of prey,which is proportional to the density of prey species with interval parameters.The model develops with natural interval parameters since the uncertainties of parameters of any ecological system are a widespread phenomenon in nature.The equilibria of the model are obtained,and the dynamic behaviours of the proposed system are examined.Simulations of the model are performed for different parameters of the model.Numerical simulations show that the proposed discrete model exhibits rich dynamics of a chaotic and complex nature.Our study,through analytical derivation and numerical example,presents the effect of refuge on population dynamics under imprecise biological parameters.展开更多
Objective:To evaluate the effectiveness of DTwP-HB-Hib vaccination dosing intervals at eight weeks versus four weeks on the immunogenicity of the diphtheria component.Methods:This is a randomized,open-label,parallel,c...Objective:To evaluate the effectiveness of DTwP-HB-Hib vaccination dosing intervals at eight weeks versus four weeks on the immunogenicity of the diphtheria component.Methods:This is a randomized,open-label,parallel,controlled trial on healthy two-month-old infants who had not received DTwP-HB-Hib vaccinations.The infants received three doses of the vaccine either at an eight-week or four-week interval.The anti-diphtheria toxoid IgG antibody levels before and after three doses of the vaccination were measured using ELISA.Results:Eighty infants were enrolled in this study,with 64 fulfilling the study requirements and randomized into two groups.All study participants exhibited uncertain protection against diphtheria antibodies(0.01-0.99 IU/mL)at the beginning of the study with an average of(0.023±0.009)IU/mL and(0.026±0.009)IU/mL in eight weeks and four weeks groups.Following three doses of the vaccination,the antibody level rose to an average of(1.320±0.234)IU/mL in the eight-week group and(1.307±0.186)IU/mL in the four-week group,with no statistically significant difference in the antibody levels observed(P=0.814).Conclusions:DTwP-HB-Hib vaccinations can be administered at an eight-week or four-week interval,as they do not significantly affect the level of anti-diphtheria IgG antibodies.展开更多
Control of the wetting properties of biomimetic functional surfaces is a desired functionality in many applications.In this paper,the photoresist SU-8 was used as fabrication material.A silicon wafer was used as a sub...Control of the wetting properties of biomimetic functional surfaces is a desired functionality in many applications.In this paper,the photoresist SU-8 was used as fabrication material.A silicon wafer was used as a substrate to prepare a biomimetic surface with different surface roughness and micro-pillars arranged in array morphology.The evaporation dynamics and interfacial heat transfer processes of deionised water droplets on the bioinspired microstructure surface were experimentally studied.The study not only proves the feasibility of preparing hydrophilic biomimetic functional surfaces directly through photoresist materials and photolithography technology but also shows that by adjusting the structural parameters and arrangement of the surface micro-pillar structure,the wettability of the biomimetic surface can be significantly linearly regulated,thereby effectively affecting the heat and mass transfer process at the droplet liquid-vapour interface.Analysis of the results shows that by controlling the biomimetic surface microstructure,the wettability can be enhanced by about 22%at most,the uniformity of the temperature distribution at the liquid-vapour interface can be improved by about 34%,and the average evaporation rate can be increased by about 28%.This study aims to provide some guidance for the research on bionic surface design based on photoresist materials.展开更多
The primary objective of this work is to improve our understanding of the mechanical involvements of two-order roughness in shear.First,wavelet analysis is used to separate the waviness(first-order)and unevenness(seco...The primary objective of this work is to improve our understanding of the mechanical involvements of two-order roughness in shear.First,wavelet analysis is used to separate the waviness(first-order)and unevenness(second-order)from four granite joint surfaces,with roughness characterized using Grasselli’s 3D morphology parameters.The results reveal that first-order roughness is more pronounced than second-order roughness,highlighting the dominant role of waviness in joint surface roughness.Additionally,the variation in first-order roughness with strike direction corresponds to the total roughness,while second-order roughness remains largely constant,indicating that roughness anisotropy is primarily driven by waviness.Then,direct shear tests on joint replicas are performed to investigate the contributions of both roughness orders to peak shear strength.The results show that the peak dilation angle is closely related to first-order roughness,while the shear component angle is closely associated with second-order roughness,both exhibiting a linear correlation.Based on these findings,relationships are established between the angles and their respective roughness orders.Finally,a joint shear strength criterion based on two-order roughness is proposed.A comparative analysis of prediction accuracy reveals that the average relative error for the proposed criterion is 13.79%,while the errors for Xia's,Yang's,and Ban's criteria are 15.19%,16.29%,and 13.87%,respectively.It demonstrates the proposed criterion can predict the peak shear strength of rock joints.展开更多
Owing to process conditions such as uneven clearance of base metal assembly and welding deformation,it is difficult to obtain well-formed structural welds with robot constant specification parameters welding.Determini...Owing to process conditions such as uneven clearance of base metal assembly and welding deformation,it is difficult to obtain well-formed structural welds with robot constant specification parameters welding.Determining how to extract a structured,anti-interference,concise,and dynamic knowledge model from measurable data,and then adjust the welding parameters with corresponding control methods in real time is a central problem to be solved in welding formation control.Hence,this paper proposes a welding penetration control method based on a Neighborhood Rough Set-Adaptive Neuro-Fuzzy Inference System(NRS-ANFIS)to achieve effective penetration control for the GMAW welding process.In orthogonal experiments,the NRS algorithm,which is based on visual sensing to obtain the properties of the weld pool and gap changes,is used to reduce the established frontal weld pool feature information decision table,and the minimum feature set of the weld pool tail width WTand the tail area coefficient CTSis obtained.The minimum feature set of the effective frontal weld pool,real-time line laser distance change,and real-time current information are used as the input for the ANFIS control system.The experimental results for the two groups of time-varying gaps demonstrate that under the condition of no preheating of the base metal,the complete welding penetration rate of the adjusted welding process parameters output by the trained ANFIS model reaches 87%,and the backside melting width is uniform and consistent,which meets the welding specification requirements.展开更多
基金funding from the National Natural Science Foundation of China (Grant No.42277175)the pilot project of cooperation between the Ministry of Natural Resources and Hunan Province“Research and demonstration of key technologies for comprehensive remote sensing identification of geological hazards in typical regions of Hunan Province” (Grant No.2023ZRBSHZ056)the National Key Research and Development Program of China-2023 Key Special Project (Grant No.2023YFC2907400).
文摘Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability.
基金funding support from the National Natural Science Foundation of China(Grant No.52274082)the Program of Qingjiang Excellent Young Talents,Jiangxi University of Science and Technology(Grant No.JXUSTQJBJ2020003)the Innovation Fund Designated for Graduate Students of Jiangxi Province(Grant No.YC2023-B215).
文摘The roughness of the fracture surface directly affects the strength,deformation,and permeability of the surrounding rock in deep underground engineering.Understanding the effect of high temperature and thermal cycle on the fracture surface roughness plays an important role in estimating the damage degree and stability of deep rock mass.In this paper,the variations of fracture surface roughness of granite after different heating and thermal cycles were investigated using the joint roughness coefficient method(JRC),three-dimensional(3D)roughness parameters,and fractal dimension(D),and the mechanism of damage and deterioration of granite were revealed.The experimental results show an increase in the roughness of the granite fracture surface as temperature and cycle number were incremented.The variations of JRC,height parameter,inclination parameter and area parameter with the temperature conformed to the Boltzmann's functional distribution,while the D decreased linearly as the temperature increased.Besides,the anisotropy index(Ip)of the granite fracture surface increased as the temperature increased,and the larger parameter values of roughness characterization at different temperatures were attained mainly in directions of 20°–40°,60°–100°and 140°–160°.The fracture aperture of granite after fracture followed the Gauss distribution and the average aperture increased with increasing temperature,which increased from 0.665 mm at 25℃to 1.058 mm at 800℃.High temperature caused an uneven thermal expansion,water evaporation,and oxidation of minerals within the granite,which promoted the growth and expansion of microfractures,and reduced interparticle bonding strength.In particular,the damage was exacerbated by the expansion and cracking of the quartz phase transition after T>500℃.Thermal cycles contributed to the accumulation of this damage and further weakened the interparticle bonding forces,resulting in a significant increase in the roughness,anisotropy,and aperture of the fracture surface after five cycles.
基金Supported by NSFC(No.11971295)Guangdong Higher Education Teaching Reform Project(No.2023307)。
文摘Let Ω be homogeneous of degree zero,integrable on S^(n−1) and have mean value zero,T_(Ω) be the homogeneous singular integral operator with kernel Ω(x)/|x|^(n) and[b,T_(Ω)]be the commutator of T_(Ω)with symbol b∈BMO(R^(n)).In this paper,the authors prove that if sup ζ∈S^(n−1)∫Sn−1^(|Ω(θ)|log^(β)(1/|θ·ζ|)dθ<∞ with β>2,then[b,T_(Ω)]is bounded on Triebel–Lizorkin space F^(0,q)p(R^(n))provided that 1+1/β−1<p,q<β.
文摘Pavement condition monitoring and its timely maintenance is necessary to ensure the safety and quality of the roadway infrastructure. The International Roughness Index (IRI) is a commonly used measure to quantify road surface roughness and is a critical input to asset management. In Indiana, the IRI statistic contributes to roughly half of the pavement quality index computation used for asset management. Most agencies inventory IRI once a year, however, pavement conditions vary much more frequently. The objective of this paper is to develop a framework using crowdsourced connected vehicle data to identify and detect temporal changes in IRI. Over 3 billion connected vehicle records in Indiana were analyzed across 30 months between 2022 and 2024 to understand the spatiotemporal variations in roughness. Annual comparisons across all major interstates in Indiana showed the miles of interstates classified as “Good” decreased from 1896 to 1661 miles between 2022 and 2024. The miles of interstate classified as “Needs Maintenance” increased from 82 to 120 miles. A detailed case study showing monthly and daily changes of estimated IRI on I-65 are presented along with supporting dashcam images. Although the crowdsourced IRI estimates are not as robust as traditional specialized pavement profilers, they can be obtained on a monthly, weekly, or even daily basis. The paper concludes by suggesting a combination of frequent crowdsourced IRI and commercially available dashcam imagery of roadway can provide an agile and responsive mechanism for agencies to implement pavement asset management programs that can complement existing annual programs.
文摘LetΩbe homogeneous of degree zero,integrable on S^(d−1) and have vanishing moment of order one,a be a function on R^(d) such that ∇a∈L^(∞)(R^(d)).Let T*_(Ω,a) be the maximaloperator associated with the d-dimensional Calder´on commutator defined by T*_(Ωa)f(x):=sup_(ε>0)|∫_(|x-y|>ε)^Ω(x-y)/|x-y|^(d+1)(a(x)-a(y))f(y)dy.In this paper,the authors establish bilinear sparse domination for T*_(Ω,a) under the assumption Ω∈L∞(Sd−1).As applications,some quantitative weighted bounds for T*_(Ω,a) are obtained.
基金supported by the National Natural Science Foundation of China,Nos.82071426,81873784Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(all to DF)。
文摘Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.
基金College Students Innovation and Entrepreneurship Project of Guangzhou Railway Polytechnic(2025CXCY015)。
文摘As the dominant seepage channel in rock masses,it is of great significance to study the influence of fracture roughness distribution on seepage and heat transfer in rock masses.In this paper,the fracture roughness distribution functions of the Bakhtiary dam site and Oskarshamn/Forsmark mountain were fitted using statistical methods.The COMSOL Multiphysics finite element software was utilized to analyze the effects of fracture roughness distribution types and empirical formulas for fracture hydraulic aperture on the seepage field and temperature field of rock masses.The results show that:(1)The fracture roughness at the Bakhtiary dam site and Oskarshamn/Forsmark mountain follows lognormal and normal distributions,respectively;(2)For rock masses with the same expected value and standard deviation of fracture roughness,the outflow from rock masses with lognormal distribution of fracture roughness is significantly larger than that of rock masses with normal distribution of fracture roughness;(3)The fracture hydraulic aperture,outflow,and cold front distance of the Li and Jiang model are significantly larger than those of the Barton model;(4)The outflow,hydraulic pressure distribution,and temperature distribution of the Barton model are more sensitive to the fracture roughness distribution type than those of the Li and Jiang model.
文摘BACKGROUND Pepsinogen(PG)and the PG I/II ratio(PGR)are critical indicators for diagnosing Helicobacter pylori infection and chronic atrophic gastritis,and assessing gastric cancer risk.Existing reference intervals(RIs)often overlook age,sex,and demographic variations.Partitioned RIs,while considering these factors,fail to capture the gradual age-related physiological changes.Next-generation RIs offer a solution to this limitation.AIM To investigate age-and sex-specific dynamics of PG and establish next-generation RIs for adults and the elderly in northern China.METHODS After screening,708 healthy individuals were included in this observational study.Serum PG was measured using chemiluminescence immunoassay.Age-and sex-related effects on PG were analyzed with a two-way analysis of variance.RI partitioning was determined by the standard deviation ratio(SDR).Traditional RIs were established using a non-parametric approach.Generalized Additive Models for Location,Scale,and Shape(GAMLSS)modeled age-related trends and continuous reference percentiles for PG I and PG II.Reference limit flagging rates for both RI types were compared.RESULTS PG I and PG II levels were influenced by age(P<0.001)and sex(P<0.001),while PGR remained stable.Age-specific RIs were required for PG I(SDR=0.366)and PG II(SDR=0.424).Partitioned RIs were established for PG I and PG II,with a single RI for PGR.GAMLSS modeling revealed distinct age-dependent trajectories:PG I increased from a median of 39.75μg/L at age 20 years to 49.75μg/L at age 60 years,a 25.16%increase,after which it plateaued through age 80 years.In contrast,PG II showed a continuous rise throughout the age range,with the median value increasing from 5.07μg/L at age 20 years to 8.36μg/L at age 80 years,corresponding to a 64.89%increase.Continuous reference percentiles intuitively reflected these trends and were detailed in this study.Next-generation RIs demonstrated superior accuracy compared to partitioned RIs when applied to specific age subgroups.CONCLUSION This study elucidates the age-and sex-specific dynamics of PG and,to our knowledge,is the first to establish next-generation RIs for PG,supporting more individualized interpretation in laboratory medicine.
基金Supported by the National Natural Science Foundation of China(Grant No.12001006)the Natural Science Foundation of Universities of Anhui Province(Grant No.2023AH050904).
文摘The distribution of Seidel eigenvalues of cographs is investigated in this paper.We prove that there is no Seidel eigenvalue of nontrivial cographs in the interval(−1,1).We also show the optimality of the interval(−1,1)in the sense that for any ε>0 either of the intervals(1,1+ε)and(−1−ε,−1)contains a Seidel eigenvalue of some cograph of order n when n is sufficiently large.
基金financially supported by the National Natural Science Foundation of China(Nos.42277149,41502299,41372306)the Research Planning of Sichuan Education Department,China(No.16ZB0105)+3 种基金the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Independent Research Project(Nos.SKLGP2016Z007,SKLGP2018Z017,SKLGP2020Z009)Chengdu University of Technology Young and Middle Aged Backbone Program(No.KYGG201720)Sichuan Provincial Science and Technology Department Program(No.19YYJC2087)China Scholarship Council。
文摘To tackle the difficulties of the point prediction in quantifying the reliability of landslide displacement prediction,a data-driven combination-interval prediction method(CIPM)based on copula and variational-mode-decomposition associated with kernel-based-extreme-learningmachine optimized by the whale optimization algorithm(VMD-WOA-KELM)is proposed in this paper.Firstly,the displacement is decomposed by VMD to three IMF components and a residual component of different fluctuation characteristics.The key impact factors of each IMF component are selected according to Copula model,and the corresponding WOA-KELM is established to conduct point prediction.Subsequently,the parametric method(PM)and non-parametric method(NPM)are used to estimate the prediction error probability density distribution(PDF)of each component,whose prediction interval(PI)under the 95%confidence level is also obtained.By means of the differential evolution algorithm(DE),a weighted combination model based on the PIs is built to construct the combination-interval(CI).Finally,the CIs of each component are added to generate the total PI.A comparative case study shows that the CIPM performs better in constructing landslide displacement PI with high performance.
基金supported by the Key Discipline Program of the Fifth Round of the Three-Year Public Health Action Plan(2020-2022 Year)of Shanghai,China(GWV-10.1-XK08).
文摘Objectives:This study aimed to explore the perceptions and recommendations of multiparas and health-related professionals regarding appropriate birth intervals(Bis)and key determinants.Methods:In-depth semi-structured interviews were conducted between April 1 and June 30,2022.Nine multiparas and thirteen health-related professionals were purposefully sampled until data saturation was reached.A thematic analysis approach was applied to the interview transcripts,utilizing dual independent coding and consensus validation in NVivo 12.0.Results:The data generated two overarching categories:1)balanced decision-making on the appropriate birth intervals and 2)internal and external determinants integrated with health and societal considerations.Four key themes emerged following the two categories:1)consistency and discrepancy between the actual and recommended birth intervals of multiparas;2)health-and developmentoriented professional recommendations;3)internal determinants related to individual-level factors;and 4)external determinants related to child-related factors,family support,and social security.Weighing women's reproductive health and career development,multiparas and health-related professionals perceived a length between 18 and 36 months as the appropriate Bl.Conclusion:Multiparas and health-related professionals shaped their balanced recommendations on a relatively appropriate birth interval ranging from 18 to 36 months,which was influenced by women's individual-level factors,child-related factors,family support,and social security.Targeted social and healthcare services should be offered to women and their families during the Bls.
文摘Purpose We aimed to determine:(a)the chronic effects of interval training(IT)combined with blood flow restriction(BFR)on physiological adaptations(aerobic/anaerobic capacity and muscle responses)and performance enhancement(endurance and sprints),and(b)the influence of participant characteristics and intervention protocols on these effects.Methods Searches were conducted in PubMed,Web of Science(Core Collection),Cochrane Library(Embase,ClinicalTrials.gov,and International Clinical Trials Registry Platform),and Chinese National Knowledge Infrastructure on April 2,with updates on October 17,2024.Pooled effects for each outcome were summarized using Hedge's g(g)through meta-analysis-based random effects models,and subgroup and regression analyses were used to explore moderators.Results A total of 24 studies with 621 participants were included.IT combined with BFR(IT+BFR)significantly improved maximal oxygen uptake(VO2_(max))(g=0.63,I^(2)=63%),mean power during the Wingate 30-s test(g=0.70,I^(2)=47%),muscle strength(g=0.88,I^(2)=64%),muscle endurance(g=0.43,I^(2)=0%),time to fatigue(g=1.26,I^(2)=86%),and maximal aerobic speed(g=0.74,I^(2)=0%)compared to IT alone.Subgroup analysis indicated that participant characteristics including training status,IT intensity,and IT modes significantly moderated VO2_(max)(subgroup differences:p<0.05).Specifically,IT+BFR showed significantly superior improvements in VO2_(max)compared to IT alone in trained individuals(g=0.76)at supra-maximal intensity(g=1.29)and moderate intensity(g=1.08)as well as in walking(g=1.64)and running(g=0.63)modes.Meta-regression analysis showed cuff width(β=0.14)was significantly associated with VO2_(max)change,identifying 8.23 cm as the minimum threshold required for significant improvement.Subgroup analyses regarding muscle strength did not reveal any significant moderators.Conclusion IT+BFR enhances physiological adaptations and optimizes aspects of endurance performance,with moderators including training status,IT protocol(intensity,mode,and type),and cuff width.This intervention addresses various IT-related challenges and provides tailored protocols and benefits for diverse populations.
文摘In the present paper,we obtain the converse results of approximation of a newly introduced genuine Bernstein-Durrmeyer operators in movable interval.We also get the moments properties of an auxiliary operator which has its own independent values.The moments of the auxiliary operators play important roles in establishing the main result(Theorem 4).
基金supported by the Na-tional Natural Science Foundation of China(No.51675457)the Jiangsu Key Laboratory of Precision and Micro-man-ufacturing Technology.
文摘Sapphire hemispherical domes are machined through milling and shaping using brazed diamond tools.A mathematical model describing roughness for this processing method is established,and the relationship between roughness and its influencing factors is analyzed.Experiments on the hemispherical dome shaping process are conducted to validate the model,analyzing the variation in roughness under different tool and workpiece rotational speeds.The results are consistent with the predictions of the established roughness model,suggesting that the model can be used to guide subsequent process experiments.Milling and shaping efficiency using brazed diamond tools typically can reach 14 g/min.The machined sapphire surfaces exhibit relatively few microcracks and minimal damage,with almost all exclusively visible grooves resulting from brittle fracture removal.The surface roughness after machining is below 2.5μm.Milling sapphire domes with brazed diamond tools represents a novel shaping technique characterized by high efficiency and high quality.
文摘High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence to analyze mechanisms of HIIT in neuromuscular activation,hormonal responses,muscle fiber adaptation,and metabolic pathway effects.It focuses on its effectiveness in enhancing explosive power,maximum strength,and strength endurance,while also examining the integration of HIIT with traditional resistance training,periodized programming,and personalized prescription.Scientific implementation of HIIT can effectively diversify or even replace conventional strength training,not only offering positive directional changes for strength development but also introducing innovative approaches to sports performance training practices.
文摘This paper presents the dynamical properties of a discrete-time prey-predator model with refuge in prey under imprecise biological parameters.We consider the refuge concept of prey,which is proportional to the density of prey species with interval parameters.The model develops with natural interval parameters since the uncertainties of parameters of any ecological system are a widespread phenomenon in nature.The equilibria of the model are obtained,and the dynamic behaviours of the proposed system are examined.Simulations of the model are performed for different parameters of the model.Numerical simulations show that the proposed discrete model exhibits rich dynamics of a chaotic and complex nature.Our study,through analytical derivation and numerical example,presents the effect of refuge on population dynamics under imprecise biological parameters.
文摘Objective:To evaluate the effectiveness of DTwP-HB-Hib vaccination dosing intervals at eight weeks versus four weeks on the immunogenicity of the diphtheria component.Methods:This is a randomized,open-label,parallel,controlled trial on healthy two-month-old infants who had not received DTwP-HB-Hib vaccinations.The infants received three doses of the vaccine either at an eight-week or four-week interval.The anti-diphtheria toxoid IgG antibody levels before and after three doses of the vaccination were measured using ELISA.Results:Eighty infants were enrolled in this study,with 64 fulfilling the study requirements and randomized into two groups.All study participants exhibited uncertain protection against diphtheria antibodies(0.01-0.99 IU/mL)at the beginning of the study with an average of(0.023±0.009)IU/mL and(0.026±0.009)IU/mL in eight weeks and four weeks groups.Following three doses of the vaccination,the antibody level rose to an average of(1.320±0.234)IU/mL in the eight-week group and(1.307±0.186)IU/mL in the four-week group,with no statistically significant difference in the antibody levels observed(P=0.814).Conclusions:DTwP-HB-Hib vaccinations can be administered at an eight-week or four-week interval,as they do not significantly affect the level of anti-diphtheria IgG antibodies.
基金supported by H2020-MSCA-RISE-778104–ThermaSMART,Royal Society(IEC\NSFC\211210)doctoral degree scholarship of China Scholarship Council(CSC).
文摘Control of the wetting properties of biomimetic functional surfaces is a desired functionality in many applications.In this paper,the photoresist SU-8 was used as fabrication material.A silicon wafer was used as a substrate to prepare a biomimetic surface with different surface roughness and micro-pillars arranged in array morphology.The evaporation dynamics and interfacial heat transfer processes of deionised water droplets on the bioinspired microstructure surface were experimentally studied.The study not only proves the feasibility of preparing hydrophilic biomimetic functional surfaces directly through photoresist materials and photolithography technology but also shows that by adjusting the structural parameters and arrangement of the surface micro-pillar structure,the wettability of the biomimetic surface can be significantly linearly regulated,thereby effectively affecting the heat and mass transfer process at the droplet liquid-vapour interface.Analysis of the results shows that by controlling the biomimetic surface microstructure,the wettability can be enhanced by about 22%at most,the uniformity of the temperature distribution at the liquid-vapour interface can be improved by about 34%,and the average evaporation rate can be increased by about 28%.This study aims to provide some guidance for the research on bionic surface design based on photoresist materials.
基金funded by the National Natural Science Foundation of China (Grant nos. 42272333 and 42377154)the China Association for Science and Technology Youth Talent Support Program for PhD Students.
文摘The primary objective of this work is to improve our understanding of the mechanical involvements of two-order roughness in shear.First,wavelet analysis is used to separate the waviness(first-order)and unevenness(second-order)from four granite joint surfaces,with roughness characterized using Grasselli’s 3D morphology parameters.The results reveal that first-order roughness is more pronounced than second-order roughness,highlighting the dominant role of waviness in joint surface roughness.Additionally,the variation in first-order roughness with strike direction corresponds to the total roughness,while second-order roughness remains largely constant,indicating that roughness anisotropy is primarily driven by waviness.Then,direct shear tests on joint replicas are performed to investigate the contributions of both roughness orders to peak shear strength.The results show that the peak dilation angle is closely related to first-order roughness,while the shear component angle is closely associated with second-order roughness,both exhibiting a linear correlation.Based on these findings,relationships are established between the angles and their respective roughness orders.Finally,a joint shear strength criterion based on two-order roughness is proposed.A comparative analysis of prediction accuracy reveals that the average relative error for the proposed criterion is 13.79%,while the errors for Xia's,Yang's,and Ban's criteria are 15.19%,16.29%,and 13.87%,respectively.It demonstrates the proposed criterion can predict the peak shear strength of rock joints.
基金Supported by National Natural Science Foundation of China(Grant Nos.52261044,51969001)the Guangxi Provincial Science and Technology Major Project(Grant No.Guike AA23062037)Research Foundation Ability Enhancement Project for Young and Middle Aged Teachers in Guangxi Universities of China(Grant No.2024KY0441)。
文摘Owing to process conditions such as uneven clearance of base metal assembly and welding deformation,it is difficult to obtain well-formed structural welds with robot constant specification parameters welding.Determining how to extract a structured,anti-interference,concise,and dynamic knowledge model from measurable data,and then adjust the welding parameters with corresponding control methods in real time is a central problem to be solved in welding formation control.Hence,this paper proposes a welding penetration control method based on a Neighborhood Rough Set-Adaptive Neuro-Fuzzy Inference System(NRS-ANFIS)to achieve effective penetration control for the GMAW welding process.In orthogonal experiments,the NRS algorithm,which is based on visual sensing to obtain the properties of the weld pool and gap changes,is used to reduce the established frontal weld pool feature information decision table,and the minimum feature set of the weld pool tail width WTand the tail area coefficient CTSis obtained.The minimum feature set of the effective frontal weld pool,real-time line laser distance change,and real-time current information are used as the input for the ANFIS control system.The experimental results for the two groups of time-varying gaps demonstrate that under the condition of no preheating of the base metal,the complete welding penetration rate of the adjusted welding process parameters output by the trained ANFIS model reaches 87%,and the backside melting width is uniform and consistent,which meets the welding specification requirements.
