One-time application of controlled-release blended fertilizer(CRBF,a mixture of five nitrogen(N)fertilizers in a certain ratio)can achieve high yield and N use efficiency(NUE)in rice(Oryza sativa L.).However,the effec...One-time application of controlled-release blended fertilizer(CRBF,a mixture of five nitrogen(N)fertilizers in a certain ratio)can achieve high yield and N use efficiency(NUE)in rice(Oryza sativa L.).However,the effects of CRBF with one-time application on root spatial distribution and physiological characteristics remain unclear.We measured the effects of CRBF with one-time application on rice yield,NUE,root morphology and growth,and N uptake capacity in field and root box experiments.Six N treatments were set up:no nitrogen(N0),high-yield three-split application of urea as a control(CK),urea(U)with broadcast,U with side-deep fertilization,CRBF with broadcast,and CRBF with side-deep fertilization.Our findings showed that root characters were positively correlated with yield and NUE.Compared to CK and U treatments,CRBF with one-time applications increased root characters(including root biomass,root N uptake,root activity,and the expression level of ammonium transporters)at tillering and heading stages.The root length,surface area and volume in the 0-10 cm soil layer enhanced under CRBF with one-time applications at tillering stage,and in the 0-20 cm soil layer at the heading stage.This contributed a5.96%-39.40% and 3.69%-16.87% increase in plant dry matter accumulation and N uptake,and a2.08%-18.28% and 14.60%-149.57% increase in yield and NUE,in 2022 and 2023,respectively.Taken together,our findings showed that one-time application of CRBF could increase rice yield and NUE by optimizing the root morphology distribution and N uptake.展开更多
Aligning leaf nitrogen(N) distribution to match the light gradient is crucial for maximizing canopy dry matter production(DMP) and improving N utilization efficiency. However, the relationship between the gradient of ...Aligning leaf nitrogen(N) distribution to match the light gradient is crucial for maximizing canopy dry matter production(DMP) and improving N utilization efficiency. However, the relationship between the gradient of root-derived cytokinins and N distribution in rice leaves and its impact on DMP and the underlying mechanisms remains poorly understood. A two-year field experiment was conducted using two japonica N-efficient varieties(NEVs) and two japonica N-inefficient varieties(NIVs) under four different N rates(0, 90, 180, and 360 kg N ha^(-1)). These selected varieties exhibited similar values in the coefficient of light extinction(K_(L)). Results showed that at lower N rates(0–180 kg N ha^(-1)), the NEVs exhibited greater dry matter weight at maturity, higher grain yield, and improved internal N use efficiency(IE_(N)) compared to the NIVs, despite possessing comparable total N uptake. Compared with the NIVs, the NEVs exhibited a more pronounced nitrogen distribution gradient in leaves, as indicated by the coefficient of nitrogen extinction(K_(N)) values during the middle and early grain-filling stages. This enhanced gradient led to improved coordination between light and nitrogen, resulting in greater photosynthetic production, particularly at lower N rates. Furthermore, the NEVs demonstrated a larger gradient of zeatin(Z)+zeatin riboside(ZR) in leaves(i.e., higher ratios of Z+ZR levels between upper and lower leaves), enhanced expression levels of genes related to N export in lower leaves and Z+ZR loading in the root, respectively, elevated enzymes activities related to N assimilation in upper leaves, in relative to the NIVs. Correlation and random forest analyses demonstrated a strong positive correlation between the Z+ZR gradient, K_(N), and DMP, and the gradient facilitated the export of N from lower leaves and its assimilation in upper leaves, contributing significantly to both K_(N) and DMP. This process was closely linked to root activity, including root oxidation activity, root Z+ZR content, and Z+ZR loading capacity, as confirmed by applying an inhibitor or a promoter of cytokinins biosynthesis to roots. Interestingly, at the N rate of 360 kg N ha^(-1), both NEVs and NIVs showed indistinguishable plant traits, achieving a super high-yielding level(over 10.5 t ha^(-1)) but with remarkably low IE_(N). The results suggest that increasing the Z+ZR gradient can improve K_(N) and DMP, where it needs to maintain higher root activity, thus leading to high yield and high IE_(N). Further research is needed to explore and develop cultivation practices with reduced N to unlock the super-high-yielding potential of the NEVs.展开更多
Forests play an important role in controlling the formation and movement processes of debris flows.They contribute to soil stabilization,regulation of soil water content,and act as robust structures impeding the downs...Forests play an important role in controlling the formation and movement processes of debris flows.They contribute to soil stabilization,regulation of soil water content,and act as robust structures impeding the downstream progression of debris flows.On the positive side,trees,to some extent,can intercept debris flows and effectively mitigate their velocity by increasing flow resistance.On the negative side,trees may suffer damage from debris-flow hazards,characterized by the generation of substantial quantities of wood fragments and consequential ramifications such as river channel blockage,resulting in backwater rise.In extreme cases,this blockage collapse can lead to instantaneous discharge amplification,thereby adversely impacting urban safety and impeding sustainable development.Therefore,in order to grasp the effects of tree characteristics on tree failure modes,the tree failure modes and corresponding parameters,diameters at breast height(DBH)and root-soil plate size,were identified and recorded through the post-event field investigation in Keze Gully,a region prone to debrisflow events in Sichuan,China,respectively.To investigate the impact of spatial variability in tree root distribution on tree failure modes,the root crosssectional area ratio(RAR),root density(RD),root length density(RLD)and soil detachment rate(SDR)were obtained.The findings indicated that:(1)Tree characteristics reflect the interactions of debris flows and trees,and influence the tree failure modes ultimately.The root distribution characteristics influence the size and shape of the root-soil plate to affect the resistance of trees.(2)Compared to burial and abrasion,stem breakage and overturning are the predominant modes of tree failure in debris-flow hazards.Trees with a smaller DBH primarily experience stem breakage and bending,and trees with a larger DBH mostly experience overturning.(3)The root-soil plate shapes of overturned trees,affected by the root architecture and root growth range,are generally semielliptical or semicircular,and the horizontal and vertical radii increase with DBH,but the correlation between the root-soil plate’s breadth-depth ratio and DBH is low.(4)The biomass and RAR decrease with distance.The RAR distribution exhibit the order of upslope direction>downslope direction>lateral direction.The coarse root biomass significantly increases with DBH,but no clear trend in fine root biomass.(5)The roots can significantly enhance the soil erosion resistance,but the erosion resistance of coarse roots is not as significant as that of fine roots.The erosion resistance increases with DBH,and follows the order of upslope direction>downslope direction>lateral direction.The results could provide new insights into the influences of tree and root distribution characteristics on tree failure modes during debris flows.展开更多
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin a...The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.展开更多
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci...The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.展开更多
Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antib...Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antibiotic resistance,leading to suboptimal treatment outcomes.Thus,it is challenging to remove the organic biofilms from root canals.In recent years,light-responsive therapy,with deeper tissue penetration than traditional treatments,has emerged as an effective RCT modality.Herein,this review summarizes the recent development of light-responsive nanomaterials for biofilm removal in RCT.The light-responsive nanomaterials and the corresponding therapeutic methods in RCT,including photodynamic therapy(PDT),photothermal therapy(PTT),and laser-activated therapy,are highlighted.Finally,the challenges that light-responsive nanomaterials and treatment modalities will encounter to conquer the biofilm in future RCT are discussed.This review is believed to significantly accelerate the future development of light-responsive nanomaterials for RCT from bench to bedside.展开更多
Intercropping has been widely used in arid and semi-arid regions because of its high yield,stable productivity,and efficient utilization of resources.However,in recent years,the high yield of traditional intercropping...Intercropping has been widely used in arid and semi-arid regions because of its high yield,stable productivity,and efficient utilization of resources.However,in recent years,the high yield of traditional intercropping is mainly attributed to the large amount of purchased resources such as water and fertilizer,plastic film,and mechanical power.These lead to a decline in cultivated land quality and exacerbate intercrops'premature root and canopy senescence.So,the application of traditional intercropping faces major challenges in crop production.This paper analyzes the manifestations,occurrence mechanisms,and agronomic regulatory pathways of crop senescence.The physiological and ecological characteristics of intercropping to delay root and canopy senescence of crops are reviewed in this paper.The main agronomic regulatory pathways of intercropping to delay root and canopy senescence of crops are based on above-and blow-ground interactions,including collocation of crop varieties,spatial arrangement,water and fertilizer management,and tillage and mulch practices.Future research fields of intercropping to delay root and canopy senescence should focus on the aspects of selecting and breeding special varieties,application of molecular biology techniques,and developing or applying models to predict and evaluate the root and canopy senescence process of intercrops.Comprehensive analysis and evaluation of different research results could provide a basis for enhancing intercropping delay root and canopy senescence through adopting innovative technologies for regulating the physio-ecological characteristics of intercrops.This would support developing and adopting high-yield,efficient,and sustainable intercropping systems in arid and semi-arid areas with high population density,limited land,and abundant light and heat resources.展开更多
The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e...The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.展开更多
The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality d...The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality deterioration and posing a risk to public health.An in-situ scanning vibrating electrode technique(SVET)with micron-scale resolution,microscopic scale detection and water quality analysis were used to investigate the corrosion behavior and metal release from DPs throughout the whole CML failure process.Metal pollutants release occurred at three different stages of CML failure process,and there are potential risks of water quality deterioration exceeding the maximum allowable levels set by national standards in the partial failure stage and lining peeling stage.Furthermore,the effects of water chemistry(Cl^(−),SO_(4)^(2−),NO_(3)−,and Ca^(2+))on corrosion scale growth and iron release activity,were investigated during the CML partial failure stage.Results showed that the CML failure process in DPs was accelerated by the autocatalysis of localized corrosion.Cl^(−)was found to damage the uncorroded metal surface,while SO_(4)^(2−)mainly dissolved the corrosion scale surface,increasing iron release.Both the oxidation of NO_(3)−and selective sedimentation of Ca2+were found to enhance the stability of corrosion scales and inhibit iron release.展开更多
This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de...This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.展开更多
Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of society.This study explored ...Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of society.This study explored the spatiotemporal distribution characteristics of ground-level O_(3) and its precursors based on conventional pollutant and meteorological monitoring data in Zhejiang Province from 2016 to 2021.Then,a high-performance convolutional neural network(CNN)model was established by expanding the moment and the concentration variations to general factors.Finally,the response mechanism of O_(3) to the variation with crucial influencing factors is explored by controlling variables and interpolating target variables.The results indicated that the annual average MDA8-90th concentrations in Zhejiang Province are higher in the northern and lower in the southern.When the wind direction(WD)ranges from east to southwest and the wind speed(WS)ranges between 2 and 3 m/sec,higher O_(3) concentration prone to occur.At different temperatures(T),the O_(3) concentration showed a trend of first increasing and subsequently decreasing with increasing NO_(2) concentration,peaks at the NO_(2) concentration around 0.02mg/m^(3).The sensitivity of NO_(2) to O_(3) formation is not easily affected by temperature,barometric pressure and dew point temperature.Additionally,there is a minimum IRNO_(2) at each temperature when the NO_(2) concentration is 0.03 mg/m^(3),and this minimum IRNO_(2) decreases with increasing temperature.The study explores the response mechanism of O_(3) with the change of driving variables,which can provide a scientific foundation and methodological support for the targeted management of O_(3) pollution.展开更多
As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limite...As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric pollutants.To address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May 2022.The monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station data.Temporally,there were pronounced seasonal variations in air pollutants.Spatially,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial emissions.The study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in summer.In spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two rings.This study offers data support for formulating the next phase of air pollution control measures in urban areas.展开更多
Objective:To investigate the protective effects of the combined concentrated liquid extract of Pueraria lobata(Willd.)Ohwi root(P.lobata,Ge Gen)and Hovenia dulcis Thunb.(H.dulcis,Zhi Ju Zi)against ethanol-induced live...Objective:To investigate the protective effects of the combined concentrated liquid extract of Pueraria lobata(Willd.)Ohwi root(P.lobata,Ge Gen)and Hovenia dulcis Thunb.(H.dulcis,Zhi Ju Zi)against ethanol-induced liver damage in vitro,using a human hepatoma cell line G2(HepG2)cell model.Methods:HepG2 cells were cultured in medium containing 4%ethanol to establish a model of alcoholic liver damage.The cells were then treated with the combined extract obtained via cryogenic extraction.Biochemical assays and Western blot analyses were performed to assess the levels of oxidative stress markers,antioxidant enzymes,and inflammatory cytokines.In addition,activation of the phosphoinositide 3-kinase/protein kinase B(PI3K/AKT)pathway was examined to elucidate the mechanisms underlying the effects of the extract.Results:Treatment with the extract contributed to a significant reduction in the release of nitric oxide and reactive oxygen species in the ethanol-treated HepG2 cells;promoted the elevated expression of superoxide dismutase,catalase,and glutathione,indicating enhanced antioxidant defenses;and showed strong free radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals.In addition,by activating the PI3K/AKT pathway,treatment promoted increases in the expression of nuclear factor erythroid 2-related factor 2 and its downstream targets,subsequently inhibiting apoptosis.Moreover.inflammatory responses were mitigated,as indicated by reductions in the expression of tumor necrosis factor-alpha and interleukin-6,and we detected reduction in the levels of alanine aminotransferase and aspartate aminotransferase,thereby indicating hepatoprotective effects.Conclusion:The combined P.lobata root and H.dulcis extract was established to have notable antioxidative and anti-inflammatory properties,effectively alleviating ethanol-induced liver damage in vitro.These findings highlight the potential applicability of this extract as a candidate for treating alcoholic liver disease.展开更多
Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization proces...Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.展开更多
In this paper,we show that an ideal generated by matching Rota-Baxter equations is a bideal of a Hopf algebra on decorated rooted forests.We then get a bialgebraic structure on the space of decorated rooted forests mo...In this paper,we show that an ideal generated by matching Rota-Baxter equations is a bideal of a Hopf algebra on decorated rooted forests.We then get a bialgebraic structure on the space of decorated rooted forests modulo this biideal.As an application,a connected graded bialgebra and so a graded Hopf algebra on matching Rota-Baxter algebras are constructed,which simplifies the Hopf algebraic structure proposed by[Pacific J.Math.,2022,317(2):441-475].展开更多
Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution character...Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries.展开更多
The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set inco...The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.展开更多
In order to study the infiltration characteristics of grassland soil in the super large scale landslides distribution area in the upper reaches of the Yellow River,this study selected the Xiazangtan super large scale ...In order to study the infiltration characteristics of grassland soil in the super large scale landslides distribution area in the upper reaches of the Yellow River,this study selected the Xiazangtan super large scale distribution area in Jianzha County as the study area.Through experiments and numerical simulations,plant roots characteristics,soil physical properties and infiltration characteristics of naturally grazed grassland and enclosed grassland with different slope directions were compared and analyzed,and the influence of rainfall on seepage field and stability of the two grassland slopes were discussed.The results show that the highest soil moisture infiltration capacity(FIR)is found on the shady slope of the enclosed grassland(2.25),followed by the sunny slope of the enclosed grassland(1.23)and the shady slope of the naturally grazed grassland(-0.87).Correlation analysis show that soil water content,root dry weight density,total soil porosity,number of forks and root length are positively correlated with infiltration rate(P<0.05),whereas soil dry density is negatively correlated with infiltration rate(P<0.05).The results of stepwise regression analyses show that soil water content,total soil porosity,root length and number of forks are the main factors affecting soil infiltration capacity.And the ability of roots to increase soil infiltration by improving soil properties is higher than the effect of roots itself.After 60 min of simulated rainfall,the safety factors of the shady slopes of naturally grazed grassland and enclosed grassland are reduced by 29.56%and 19.63%,respectively,comparing to those before rainfall.Therefore,in this study,the roots play a crucial role in regulating soil infiltration and enhance slope stability by increasing soil water content,soil total porosity and shear strength while decreasing soil dry density.The results of this study provide theoretical evidence and practical guidance for the effective prevention and control of secondary geological disasters such as soil erosion and shallow landslide on the slope of river banks in the study area by using plant ecological measures.展开更多
BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and te...BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.展开更多
基金supported by the National Key Research and Development Program of China(2023YFD2301304,2022YFD2301404-4,2023YFD2302600,and 2022YFE0116200)Open Subjects of the Key Laboratory of Agro-Environment in the Middle and Lower Yangtze River Plain,Ministry of Agriculture and Rural Affairs of China(2023F12)+1 种基金National Natural Science Foundation of China(32301964)Sanya Yazhou Bay Science and Technology City Project(SKJC-2023-02-004)。
文摘One-time application of controlled-release blended fertilizer(CRBF,a mixture of five nitrogen(N)fertilizers in a certain ratio)can achieve high yield and N use efficiency(NUE)in rice(Oryza sativa L.).However,the effects of CRBF with one-time application on root spatial distribution and physiological characteristics remain unclear.We measured the effects of CRBF with one-time application on rice yield,NUE,root morphology and growth,and N uptake capacity in field and root box experiments.Six N treatments were set up:no nitrogen(N0),high-yield three-split application of urea as a control(CK),urea(U)with broadcast,U with side-deep fertilization,CRBF with broadcast,and CRBF with side-deep fertilization.Our findings showed that root characters were positively correlated with yield and NUE.Compared to CK and U treatments,CRBF with one-time applications increased root characters(including root biomass,root N uptake,root activity,and the expression level of ammonium transporters)at tillering and heading stages.The root length,surface area and volume in the 0-10 cm soil layer enhanced under CRBF with one-time applications at tillering stage,and in the 0-20 cm soil layer at the heading stage.This contributed a5.96%-39.40% and 3.69%-16.87% increase in plant dry matter accumulation and N uptake,and a2.08%-18.28% and 14.60%-149.57% increase in yield and NUE,in 2022 and 2023,respectively.Taken together,our findings showed that one-time application of CRBF could increase rice yield and NUE by optimizing the root morphology distribution and N uptake.
基金supported by the National Natural Science Foundation of China (32301930, 32071943, 32272198, and 32372214)the Major Program of the Ministry of Agriculture and Rural Affairs of China (FSNK202218080316)+3 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD-2020-01)the Jiangsu Funding Program for Excellent Postdoctoral Talent, China (2022ZB618)the Government Funding to the Chinese University of Hong Kong State Key Laboratory of Agrobiotechnology via Innovation and Technology Commission, China (2022/23–2023/24)the National Key Research and Development Program of China (2022YFD2300304)。
文摘Aligning leaf nitrogen(N) distribution to match the light gradient is crucial for maximizing canopy dry matter production(DMP) and improving N utilization efficiency. However, the relationship between the gradient of root-derived cytokinins and N distribution in rice leaves and its impact on DMP and the underlying mechanisms remains poorly understood. A two-year field experiment was conducted using two japonica N-efficient varieties(NEVs) and two japonica N-inefficient varieties(NIVs) under four different N rates(0, 90, 180, and 360 kg N ha^(-1)). These selected varieties exhibited similar values in the coefficient of light extinction(K_(L)). Results showed that at lower N rates(0–180 kg N ha^(-1)), the NEVs exhibited greater dry matter weight at maturity, higher grain yield, and improved internal N use efficiency(IE_(N)) compared to the NIVs, despite possessing comparable total N uptake. Compared with the NIVs, the NEVs exhibited a more pronounced nitrogen distribution gradient in leaves, as indicated by the coefficient of nitrogen extinction(K_(N)) values during the middle and early grain-filling stages. This enhanced gradient led to improved coordination between light and nitrogen, resulting in greater photosynthetic production, particularly at lower N rates. Furthermore, the NEVs demonstrated a larger gradient of zeatin(Z)+zeatin riboside(ZR) in leaves(i.e., higher ratios of Z+ZR levels between upper and lower leaves), enhanced expression levels of genes related to N export in lower leaves and Z+ZR loading in the root, respectively, elevated enzymes activities related to N assimilation in upper leaves, in relative to the NIVs. Correlation and random forest analyses demonstrated a strong positive correlation between the Z+ZR gradient, K_(N), and DMP, and the gradient facilitated the export of N from lower leaves and its assimilation in upper leaves, contributing significantly to both K_(N) and DMP. This process was closely linked to root activity, including root oxidation activity, root Z+ZR content, and Z+ZR loading capacity, as confirmed by applying an inhibitor or a promoter of cytokinins biosynthesis to roots. Interestingly, at the N rate of 360 kg N ha^(-1), both NEVs and NIVs showed indistinguishable plant traits, achieving a super high-yielding level(over 10.5 t ha^(-1)) but with remarkably low IE_(N). The results suggest that increasing the Z+ZR gradient can improve K_(N) and DMP, where it needs to maintain higher root activity, thus leading to high yield and high IE_(N). Further research is needed to explore and develop cultivation practices with reduced N to unlock the super-high-yielding potential of the NEVs.
基金supported by the National Natural Science Foundation of China (Grant No.41925030)the Nyingchi National Sustainable Development Experimental Zone Project (2023-SYQ-007)+1 种基金the Science and Technology Research Program of Institute of Mountain Hazards and Environment, Chinese Academy of Sciences (Grant No. IMHE-ZDRW-02)the Chinese Academy of Sciences Light of West China Program
文摘Forests play an important role in controlling the formation and movement processes of debris flows.They contribute to soil stabilization,regulation of soil water content,and act as robust structures impeding the downstream progression of debris flows.On the positive side,trees,to some extent,can intercept debris flows and effectively mitigate their velocity by increasing flow resistance.On the negative side,trees may suffer damage from debris-flow hazards,characterized by the generation of substantial quantities of wood fragments and consequential ramifications such as river channel blockage,resulting in backwater rise.In extreme cases,this blockage collapse can lead to instantaneous discharge amplification,thereby adversely impacting urban safety and impeding sustainable development.Therefore,in order to grasp the effects of tree characteristics on tree failure modes,the tree failure modes and corresponding parameters,diameters at breast height(DBH)and root-soil plate size,were identified and recorded through the post-event field investigation in Keze Gully,a region prone to debrisflow events in Sichuan,China,respectively.To investigate the impact of spatial variability in tree root distribution on tree failure modes,the root crosssectional area ratio(RAR),root density(RD),root length density(RLD)and soil detachment rate(SDR)were obtained.The findings indicated that:(1)Tree characteristics reflect the interactions of debris flows and trees,and influence the tree failure modes ultimately.The root distribution characteristics influence the size and shape of the root-soil plate to affect the resistance of trees.(2)Compared to burial and abrasion,stem breakage and overturning are the predominant modes of tree failure in debris-flow hazards.Trees with a smaller DBH primarily experience stem breakage and bending,and trees with a larger DBH mostly experience overturning.(3)The root-soil plate shapes of overturned trees,affected by the root architecture and root growth range,are generally semielliptical or semicircular,and the horizontal and vertical radii increase with DBH,but the correlation between the root-soil plate’s breadth-depth ratio and DBH is low.(4)The biomass and RAR decrease with distance.The RAR distribution exhibit the order of upslope direction>downslope direction>lateral direction.The coarse root biomass significantly increases with DBH,but no clear trend in fine root biomass.(5)The roots can significantly enhance the soil erosion resistance,but the erosion resistance of coarse roots is not as significant as that of fine roots.The erosion resistance increases with DBH,and follows the order of upslope direction>downslope direction>lateral direction.The results could provide new insights into the influences of tree and root distribution characteristics on tree failure modes during debris flows.
基金supported by the National Natural Science Foundation of China,Nos.32070534(to WY),32370567(to WY),82371874(to XL),81830032(to XL),82071421(to SL)Key Field Research and Development Program of Guangdong Province,No.2018B030337001(to XL)+2 种基金Guangzhou Key Research Program on Brain Science,No.202007030008(to XL)Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(to XL)Guangdong Basic and Applied Basic Research Foundation,Nos.2022A1515012301(to WY),2023B1515020031(to WY).
文摘The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.
基金the National Natural Science:Foundation of China(52375370)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University(2023-DXSSKF-Z02)+2 种基金the Nat-ural Science Foundation of Shanxi(202103021224049)GDAS Projects of International cooperation platform of Sci-ence and Technology(2022GDASZH-2022010203-003)Guangdong province Science and Technology Plan Projects(2023B1212060045).
文摘The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.
基金supported by the Natural Science Foundation of Jiangsu Province(No.BK20200092)。
文摘Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antibiotic resistance,leading to suboptimal treatment outcomes.Thus,it is challenging to remove the organic biofilms from root canals.In recent years,light-responsive therapy,with deeper tissue penetration than traditional treatments,has emerged as an effective RCT modality.Herein,this review summarizes the recent development of light-responsive nanomaterials for biofilm removal in RCT.The light-responsive nanomaterials and the corresponding therapeutic methods in RCT,including photodynamic therapy(PDT),photothermal therapy(PTT),and laser-activated therapy,are highlighted.Finally,the challenges that light-responsive nanomaterials and treatment modalities will encounter to conquer the biofilm in future RCT are discussed.This review is believed to significantly accelerate the future development of light-responsive nanomaterials for RCT from bench to bedside.
基金supported by the National Natural Science Foundation of China(32101857 and U21A20218)the China Agricultural University Corresponding Support Research Joint Fund(GSAU-DKZY-2024-001)+1 种基金the Science and Technology Program in Gansu Province,China(24ZDNA008and23JRRA1407)the Fuxi Young Talents Fund of Gansu Agricultural University,China(Gaufx-03Y10).
文摘Intercropping has been widely used in arid and semi-arid regions because of its high yield,stable productivity,and efficient utilization of resources.However,in recent years,the high yield of traditional intercropping is mainly attributed to the large amount of purchased resources such as water and fertilizer,plastic film,and mechanical power.These lead to a decline in cultivated land quality and exacerbate intercrops'premature root and canopy senescence.So,the application of traditional intercropping faces major challenges in crop production.This paper analyzes the manifestations,occurrence mechanisms,and agronomic regulatory pathways of crop senescence.The physiological and ecological characteristics of intercropping to delay root and canopy senescence of crops are reviewed in this paper.The main agronomic regulatory pathways of intercropping to delay root and canopy senescence of crops are based on above-and blow-ground interactions,including collocation of crop varieties,spatial arrangement,water and fertilizer management,and tillage and mulch practices.Future research fields of intercropping to delay root and canopy senescence should focus on the aspects of selecting and breeding special varieties,application of molecular biology techniques,and developing or applying models to predict and evaluate the root and canopy senescence process of intercrops.Comprehensive analysis and evaluation of different research results could provide a basis for enhancing intercropping delay root and canopy senescence through adopting innovative technologies for regulating the physio-ecological characteristics of intercrops.This would support developing and adopting high-yield,efficient,and sustainable intercropping systems in arid and semi-arid areas with high population density,limited land,and abundant light and heat resources.
基金supported by the Natural Science Fund of China(31771724)the Key Research and Development Project of Shaanxi Province(2024NC-ZDCYL-01-10).
文摘The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.
基金supported by the National Natural Science Foundation of China(Nos.51808158,52170101,and 52200116)Tianjin Natural Science Foundation(No.23JCYBJC00640).
文摘The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality deterioration and posing a risk to public health.An in-situ scanning vibrating electrode technique(SVET)with micron-scale resolution,microscopic scale detection and water quality analysis were used to investigate the corrosion behavior and metal release from DPs throughout the whole CML failure process.Metal pollutants release occurred at three different stages of CML failure process,and there are potential risks of water quality deterioration exceeding the maximum allowable levels set by national standards in the partial failure stage and lining peeling stage.Furthermore,the effects of water chemistry(Cl^(−),SO_(4)^(2−),NO_(3)−,and Ca^(2+))on corrosion scale growth and iron release activity,were investigated during the CML partial failure stage.Results showed that the CML failure process in DPs was accelerated by the autocatalysis of localized corrosion.Cl^(−)was found to damage the uncorroded metal surface,while SO_(4)^(2−)mainly dissolved the corrosion scale surface,increasing iron release.Both the oxidation of NO_(3)−and selective sedimentation of Ca2+were found to enhance the stability of corrosion scales and inhibit iron release.
基金supported by Poongsan-KAIST Future Research Center Projectthe fund support provided by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Grant No.2023R1A2C2005661)。
文摘This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance.
基金supported by the National Key Research and Development Program of China (Nos.2022YFC3702000 and 2022YFC3703500)the Key R&D Project of Zhejiang Province (No.2022C03146).
文摘Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of society.This study explored the spatiotemporal distribution characteristics of ground-level O_(3) and its precursors based on conventional pollutant and meteorological monitoring data in Zhejiang Province from 2016 to 2021.Then,a high-performance convolutional neural network(CNN)model was established by expanding the moment and the concentration variations to general factors.Finally,the response mechanism of O_(3) to the variation with crucial influencing factors is explored by controlling variables and interpolating target variables.The results indicated that the annual average MDA8-90th concentrations in Zhejiang Province are higher in the northern and lower in the southern.When the wind direction(WD)ranges from east to southwest and the wind speed(WS)ranges between 2 and 3 m/sec,higher O_(3) concentration prone to occur.At different temperatures(T),the O_(3) concentration showed a trend of first increasing and subsequently decreasing with increasing NO_(2) concentration,peaks at the NO_(2) concentration around 0.02mg/m^(3).The sensitivity of NO_(2) to O_(3) formation is not easily affected by temperature,barometric pressure and dew point temperature.Additionally,there is a minimum IRNO_(2) at each temperature when the NO_(2) concentration is 0.03 mg/m^(3),and this minimum IRNO_(2) decreases with increasing temperature.The study explores the response mechanism of O_(3) with the change of driving variables,which can provide a scientific foundation and methodological support for the targeted management of O_(3) pollution.
基金supported by the National Natural Science Foundation of China(Nos.U19A2044,42105132,42030609,41975037,and 42105133)the National Key Research and Development Program of China(No.2022YFC3703502)+1 种基金the Plan for Anhui Major Provincial Science&Technology Project(No.202203a07020003)Hefei Ecological Environment Bureau Project(No.2020BFFFD01804).
文摘As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric pollutants.To address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May 2022.The monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station data.Temporally,there were pronounced seasonal variations in air pollutants.Spatially,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial emissions.The study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in summer.In spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two rings.This study offers data support for formulating the next phase of air pollution control measures in urban areas.
基金supported by the National Natural Science Foundation of China(82004027)the Fundamental Research Funds for the Central Universities(JUSRP11961).
文摘Objective:To investigate the protective effects of the combined concentrated liquid extract of Pueraria lobata(Willd.)Ohwi root(P.lobata,Ge Gen)and Hovenia dulcis Thunb.(H.dulcis,Zhi Ju Zi)against ethanol-induced liver damage in vitro,using a human hepatoma cell line G2(HepG2)cell model.Methods:HepG2 cells were cultured in medium containing 4%ethanol to establish a model of alcoholic liver damage.The cells were then treated with the combined extract obtained via cryogenic extraction.Biochemical assays and Western blot analyses were performed to assess the levels of oxidative stress markers,antioxidant enzymes,and inflammatory cytokines.In addition,activation of the phosphoinositide 3-kinase/protein kinase B(PI3K/AKT)pathway was examined to elucidate the mechanisms underlying the effects of the extract.Results:Treatment with the extract contributed to a significant reduction in the release of nitric oxide and reactive oxygen species in the ethanol-treated HepG2 cells;promoted the elevated expression of superoxide dismutase,catalase,and glutathione,indicating enhanced antioxidant defenses;and showed strong free radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radicals.In addition,by activating the PI3K/AKT pathway,treatment promoted increases in the expression of nuclear factor erythroid 2-related factor 2 and its downstream targets,subsequently inhibiting apoptosis.Moreover.inflammatory responses were mitigated,as indicated by reductions in the expression of tumor necrosis factor-alpha and interleukin-6,and we detected reduction in the levels of alanine aminotransferase and aspartate aminotransferase,thereby indicating hepatoprotective effects.Conclusion:The combined P.lobata root and H.dulcis extract was established to have notable antioxidative and anti-inflammatory properties,effectively alleviating ethanol-induced liver damage in vitro.These findings highlight the potential applicability of this extract as a candidate for treating alcoholic liver disease.
基金supported by National Natural Science Foundation of China(62104082)Guangdong Basic and Applied Basic Research Foundation(2022A1515010746,2022A1515011228,and 2022B1515120006)the Science and Technology Program of Guangzhou(202201010458).
文摘Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.
基金Supported by NSFC(No.12101316)Belt and Road Innovative Talents Exchange Foreign Experts project(No.DL2023014002L)。
文摘In this paper,we show that an ideal generated by matching Rota-Baxter equations is a bideal of a Hopf algebra on decorated rooted forests.We then get a bialgebraic structure on the space of decorated rooted forests modulo this biideal.As an application,a connected graded bialgebra and so a graded Hopf algebra on matching Rota-Baxter algebras are constructed,which simplifies the Hopf algebraic structure proposed by[Pacific J.Math.,2022,317(2):441-475].
基金supported by the National Key Research and Development Program of China(No.2019YFC1804501)the National Natural Science Foundation of China(Nos.42122056 and U1901210)+2 种基金Guangdong Basic and Applied Basic Research Foundation(No.2021B1515020063)the Key Research and Development Program of Guangdong Province(No.2021B1111380003)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Z032).
文摘Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries.
基金supported by the National Natural Science Foundation of China(No.U21B2062).
文摘The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents.
基金supported by the National Natural Science Foundation of China(42041006)the Natural Science Foundation of Qinghai Province(2020-ZJ-906).
文摘In order to study the infiltration characteristics of grassland soil in the super large scale landslides distribution area in the upper reaches of the Yellow River,this study selected the Xiazangtan super large scale distribution area in Jianzha County as the study area.Through experiments and numerical simulations,plant roots characteristics,soil physical properties and infiltration characteristics of naturally grazed grassland and enclosed grassland with different slope directions were compared and analyzed,and the influence of rainfall on seepage field and stability of the two grassland slopes were discussed.The results show that the highest soil moisture infiltration capacity(FIR)is found on the shady slope of the enclosed grassland(2.25),followed by the sunny slope of the enclosed grassland(1.23)and the shady slope of the naturally grazed grassland(-0.87).Correlation analysis show that soil water content,root dry weight density,total soil porosity,number of forks and root length are positively correlated with infiltration rate(P<0.05),whereas soil dry density is negatively correlated with infiltration rate(P<0.05).The results of stepwise regression analyses show that soil water content,total soil porosity,root length and number of forks are the main factors affecting soil infiltration capacity.And the ability of roots to increase soil infiltration by improving soil properties is higher than the effect of roots itself.After 60 min of simulated rainfall,the safety factors of the shady slopes of naturally grazed grassland and enclosed grassland are reduced by 29.56%and 19.63%,respectively,comparing to those before rainfall.Therefore,in this study,the roots play a crucial role in regulating soil infiltration and enhance slope stability by increasing soil water content,soil total porosity and shear strength while decreasing soil dry density.The results of this study provide theoretical evidence and practical guidance for the effective prevention and control of secondary geological disasters such as soil erosion and shallow landslide on the slope of river banks in the study area by using plant ecological measures.
基金Supported by 2021 Disciplinary Construction Project in School of Dentistry,Anhui Medical University,No.2021kqxkFY05.
文摘BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.
