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Automated recognition of rock discontinuity in underground engineering using geometric feature analysis
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作者 Adili Rusuli Xiaojun Li +1 位作者 Yuyun Wang Yi Rui 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1016-1033,共18页
Discontinuities in rock masses critically impact the stability and safety of underground engineering.Mainstream discontinuities identificationmethods,which rely on normal vector estimation and clustering algorithms,su... Discontinuities in rock masses critically impact the stability and safety of underground engineering.Mainstream discontinuities identificationmethods,which rely on normal vector estimation and clustering algorithms,suffer from accuracy degradation,omission of critical discontinuities when orientation density is unevenly distributed,and need manual intervention.To overcome these limitations,this paper introduces a novel discontinuities identificationmethod based on geometric feature analysis of rock mass.By analyzing spatial distribution variability of point cloud and integrating an adaptive region growing algorithm,the method accurately detects independent discontinuities under complex geological conditions.Given that rock mass orientations typically follow a Fisher distribution,an adaptive hierarchical clustering algorithm based on statistical analysis is employed to automatically determine the optimal number of structural sets,eliminating the need for preset clusters or thresholds inherent in traditional methods.The proposed approach effectively handles diverse rock mass shapes and sizes,leveraging both local and global geometric features to minimize noise interference.Experimental validation on three real-world rock mass models,alongside comparisons with three conventional directional clustering algorithms,demonstrates superior accuracy and robustness in identifying optimal discontinuity sets.The proposed method offers a reliable and efficienttool for discontinuities detection and grouping in underground engineering,significantlyenhancing design and construction outcomes. 展开更多
关键词 Underground engineering rock mass discontinuity Orientation grouping Fisher distribution 3D point cloud Automated recognition
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血根碱调节RhoA/ROCK信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响
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作者 周飞 易松 +1 位作者 岳建彪 张上上 《免疫学杂志》 2026年第2期81-86,共6页
目的探究血根碱调节Ras同源基因家族成员A(RhoA)/Rho相关激酶(ROCK)信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响。方法取60只健康雄性8周龄SD大鼠,分为正常组(未予任何处理)、模型组(腹腔注射60 mg/kg 0.2%链脲佐菌素+骨... 目的探究血根碱调节Ras同源基因家族成员A(RhoA)/Rho相关激酶(ROCK)信号通路对糖尿病性骨质疏松症大鼠骨代谢和炎性损伤的影响。方法取60只健康雄性8周龄SD大鼠,分为正常组(未予任何处理)、模型组(腹腔注射60 mg/kg 0.2%链脲佐菌素+骨密度降低)、低剂量血根碱组(L-血根碱组)、高剂量血根碱组(H-血根碱组)、H-血根碱+抑制剂组,每组12只,L-血根碱组、H-血根碱组和H-血根碱+抑制剂组分别为造模成功大鼠予2.50 mg/(kg·d)血根碱灌胃+等量0.9%氯化钠注射液腹腔注射、6.25 mg/(kg·d)血根碱灌胃+等量0.9%氯化钠注射液腹腔注射、6.25 mg/(kg·d)血根碱灌胃+40 mg/(kg·d)Rhosin腹腔注射。各组大鼠处理8周后,使用双能X线吸收测定扫描系统测量骨密度;检测血清钙、骨钙素(OC)、骨保护素(OPG)、碱性磷酸酶(ALP)水平;行生物力学测试检测各组大鼠股骨最大载荷;HE染色观察各组大鼠胰腺组织病理学变化与股骨组织形态学;酶联免疫吸附试验检测各组大鼠血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平;Western blot实验检测各组大鼠股骨组织RhoA、ROCK1和ROCK2蛋白表达。结果与正常组相比,模型组大鼠骨密度和股骨最大载荷降低,胰岛和股骨组织被破坏,血清钙、OC、OPG含量及股骨组织RhoA、ROCK1、ROCK2蛋白表达降低,血清ALP、IL-1β、TNF-α、IL-6水平升高(P<0.05);与模型组相比,L-血根碱组、H-血根碱组大鼠骨密度和股骨最大载荷升高,胰岛和股骨组织损伤减轻,血清钙、OC、OPG含量及股骨组织RhoA、ROCK1、ROCK2蛋白表达升高,血清ALP、IL-1β、TNF-α、IL-6水平降低,且H-血根碱组上述指标变化更显著(P<0.05);与H-血根碱组相比,H-血根碱+抑制剂组逆转了血根碱对大鼠骨代谢和炎性损伤的影响。结论血根碱通过激活RhoA/ROCK信号通路改善糖尿病性骨质疏松症大鼠骨代谢,并减轻了其炎性损伤。 展开更多
关键词 骨质疏松症 糖尿病性 血根碱 大鼠 RhoA/rock信号通路 骨代谢 炎性损伤
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Food Engineering Principle课程校企协同教学的创新探索
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作者 周然 蔡紫晨 +1 位作者 余克志 沈恒 《中国现代教育装备》 2026年第1期138-141,共4页
本文探讨了在Food Engineering Principle课程中实施校企协同教学模式的必要性和优势。面对留学生教育中实践教学的挑战,提出了通过高校与企业的合作,引入企业技术人员参与教学,培养留学生的实践能力和理论知识应用能力。校企协同教学... 本文探讨了在Food Engineering Principle课程中实施校企协同教学模式的必要性和优势。面对留学生教育中实践教学的挑战,提出了通过高校与企业的合作,引入企业技术人员参与教学,培养留学生的实践能力和理论知识应用能力。校企协同教学模式充分发挥高校教师和企业教师各自优势,优化实践教学,提高了教学质量。实践证明,这种教学模式提高了留学生的培养水平,有利于提高我国的国际影响力。 展开更多
关键词 校企协同 留学生 Food engineering Principle 食品工程原理
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深成侵入岩类不平衡岩石图像数据集PlutonicRocks-13
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作者 陈忠良 胡召齐 郑超杰 《中国科学数据(中英文网络版)》 2026年第1期3-18,共16页
岩性识别是地质工作者的基本技能之一。随着人工智能的兴起,如何把地质专业人员识别岩性的能力转化成人工智能模型,提供岩性智能识别服务,让地学爱好者或者非地质专业人员也能较准确地识别岩性,成为地学领域智能服务需求之一。自然条件... 岩性识别是地质工作者的基本技能之一。随着人工智能的兴起,如何把地质专业人员识别岩性的能力转化成人工智能模型,提供岩性智能识别服务,让地学爱好者或者非地质专业人员也能较准确地识别岩性,成为地学领域智能服务需求之一。自然条件下,由于地表岩石分布不均,岩石图像数据集属于典型的长尾分布。本研究以深成侵入岩为例,选择于炳松等主编的《岩石学》中的岩石分类和命名方案,构建类不平衡的岩石图像识别研究数据集PlutonicRocks-13。本数据集包含13种常见的深成侵入岩,共4785张图片,原始图像共2.49 GB,主要岩石类型包括橄榄岩、辉石岩、角闪石岩、辉长岩、闪长岩、二长岩、正长岩、霞石正长岩、花岗闪长岩、二长花岗岩、正长花岗岩、斜长花岗岩、文象花岗岩。岩石图像主要从野外和馆藏机构采集露头和手标本图像,辅以网络渠道收集。经过筛选、处理和标注后,图像最终形成能为岩石图像分类任务提供基础数据的数据集。同时,采用岩石薄片鉴定和基于深度学习可解释性分析的数据集偏见检测等方法开展数据标注质量控制和评估。采用标注标签转换为问答对的方式,还可构建面向岩石图像分类任务的微调指令,为多模态模型的岩石图像分类任务提供指令微调数据集。本图像数据集可为岩石图像自动识别研究提供可靠的数据支撑,对地质调查、地表基质调查和地质科普等有重要的参考价值。 展开更多
关键词 岩浆岩 侵入岩 长尾分布 类不平衡 图像分类
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RhoA/ROCK信号通路在椎间盘退变中的作用
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作者 杜健强 郭子煜 +3 位作者 姚晨阳 冯其金 古恩鹏 王琳珏 《生理科学进展》 北大核心 2026年第1期52-59,共8页
椎间盘由髓核、纤维环和软骨终板组成,对维持脊柱正常生理功能至关重要。椎间盘退变(intervertebral disc degeneration,IDD)是导致腰背痛等脊柱退行性疾病的主要病理基础,给人们的健康状况造成极大的困扰。然而目前对IDD的分子机制仍... 椎间盘由髓核、纤维环和软骨终板组成,对维持脊柱正常生理功能至关重要。椎间盘退变(intervertebral disc degeneration,IDD)是导致腰背痛等脊柱退行性疾病的主要病理基础,给人们的健康状况造成极大的困扰。然而目前对IDD的分子机制仍然缺乏清晰的了解,导致缺乏有效的靶向干预措施。RAS同源家族成员A(RAS homolog family member A,RhoA)/Rho相关蛋白激酶(Rho-associated protein kinase,ROCK)信号通路是调节细胞收缩、迁移和生长的经典通路。其被激活后可参与调控细胞骨架重塑、细胞外基质代谢、生物钟节律、细胞表型改变、细胞衰老及死亡等环节,进而影响IDD的病理进程。深入探究RhoA/ROCK信号通路在IDD中的作用,不仅能揭示疾病发生的分子生物学机制,也有望为研发靶向该通路的治疗策略提供理论依据。 展开更多
关键词 椎间盘退变 RhoA/rock 信号传导 作用机制
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温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制
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作者 陈昕芳 李红 +2 位作者 苏士成 吴峰妹 黄辉 《辽宁中医杂志》 北大核心 2026年第2期204-208,F0003,共6页
目的探讨温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制。方法60只健康雄性C57BL/6小鼠用于实验研究。将小鼠暴露于烟雾和高压氧舱中诱导慢性肺源性心脏病(chronic pulmonary heart disease,CPHD)模型。... 目的探讨温阳利水方通过激活RhoA/ROCK通路改善慢性肺源性心脏病小鼠心肌细胞焦亡的机制。方法60只健康雄性C57BL/6小鼠用于实验研究。将小鼠暴露于烟雾和高压氧舱中诱导慢性肺源性心脏病(chronic pulmonary heart disease,CPHD)模型。将小鼠分为以下3组:对照组(正常条件下饲养的小鼠,接受清洁空气和0.9%氯化钠溶液作为模型组和温阳利水方组的对照,n=20),模型组(如前所述建立的CPF模型,n=20),温阳利水方组(在模型小鼠的基础上给予温阳利水方药剂治疗,n=20)。通过qPCR分析RhoA、ROCK1和ROCK2 mRNA表达。通过蛋白质印迹分析小鼠心肌组织p-MBS/t-MBS比值。通过酶联免疫吸附测定(ELISA)检测小鼠外周血炎症因子肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1β(interleukin-1β,IL-1β)和白细胞介素6(interleukin-6,IL-6)水平。组织学分析小鼠心肌受损情况。通过超声心动图检测小鼠心肌功能。通过PI染色检测焦亡细胞。通过蛋白质印迹分析焦亡相关因子高迁移率族蛋白(HMGB1)和热休克蛋白70(HSP70)的表达。结果模型组RhoA、ROCK1和ROCK2 mRNA表达较对照组升高(P<0.05),温阳利水方组RhoA、ROCK1和ROCK2 mRNA表达较模型组降低(P<0.05)。模型组p-MBS/t-MBS比值较对照组升高(P<0.05),温阳利水方组p-MBS/t-MBS比值较模型组降低(P<0.05)。模型组TNF-α、IL-1β和IL-6水平较对照组升高(P<0.05),温阳利水方组TNF-α、IL-1β和IL-6水平较模型组降低(P<0.05)。HE染色显示,与对照组小鼠心肌相比,模型组小鼠心肌细胞排列紊乱,细胞肥大,炎症细胞浸润明显(P<0.05),与模型组相比,温阳利水方显著改善了CPHD引起的病理改变(P<0.05)。马松染色作为纤维化的病理检查表明,CPHD可导致小鼠严重的心肌纤维化,温阳利水方治疗可显著减少胶原沉积(P<0.05)。模型组小鼠左室收缩压(left ventricular systolic pressure,LVSP)、左室射血分数(left ventricular ejection fraction,LVEF)和心搏量(stroke volume,SV)较对照组降低(P<0.05),温阳利水方组LVSP、LVEF和SV较模型组升高(P<0.05)。模型组小鼠心肌细胞焦亡率较对照组升高(P<0.05),温阳利水方组小鼠心肌细胞焦亡率较模型组降低(P<0.05)。模型组HMGB1和HSP70的表达较对照组升高(P<0.05),温阳利水方组HMGB1和HSP70的蛋白表达较模型组降低(P<0.05)。结论温阳利水方通过激活RhoA/ROCK通路,显著改善了CPHD小鼠模型中心肌细胞焦亡和心肌结构及功能。 展开更多
关键词 温阳利水方 RhoA/rock CPHD 心肌细胞焦亡
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Correction:Cerchar abrasivity test and its applications in rock engineering:A review
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作者 Guangzhe Zhang Kurosch Thuro +2 位作者 Zhengyang Song Wengang Dang Qingsheng Bai 《International Journal of Coal Science & Technology》 2025年第4期280-289,共10页
Correction:International Journal of Coal Science&Technology(2025)12:13 https://doi.org/10.1007/s40789-024-00731-8 In this article(Zhang et al.2025),Tables 6,7,8,10,11 and 13 contain errors as described below.
关键词 rock engineering international journal coal science technology cerchar abrasivity test ERRORS REVIEW
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Advancements in Laboratory Studies of Layered Rock Masses for Deep Engineering:Insights and Future Perspectives
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作者 Yan Zhang Kai Meng +6 位作者 Xuanmei Fan Guoqing Chen Xiangsheng Zheng Shaojun Li Tianbin Li Peng Zeng Min Xia 《Journal of Earth Science》 2025年第3期1334-1340,共7页
Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These roc... Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These rock masses are predominantly composed of sedimentary,para-metamorphic,and volcanic rock types,characterized by a set of prominent,primary bedding structural planes(layers)exhibiting relatively consistent orientations and significant spatial continuity. 展开更多
关键词 surrounding rock rock masses deep engineering laboratory studies geological formations layered rock masses sedimentary rocks deep engineering excavations hou
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基于RhoA/ROCKⅡ通路探讨水蛭改善脑缺血/再灌注小鼠脑损伤的机制
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作者 赵磊 曹玉爽 +4 位作者 郭莉琛 柴丽娟 王少峡 袁庆 胡利民 《中国药理学通报》 北大核心 2026年第1期100-106,共7页
目的探究水蛭提取物(leech)调控Rho激酶(Rhoassociated coiled-coil-forming kinase,ROCK)通路保护大脑中动脉闭塞/再灌注(middle cerebral artery occlusion/reperfu-sion,MCAO/R)小鼠血脑屏障及其作用机制。方法采用大脑中动脉线栓法... 目的探究水蛭提取物(leech)调控Rho激酶(Rhoassociated coiled-coil-forming kinase,ROCK)通路保护大脑中动脉闭塞/再灌注(middle cerebral artery occlusion/reperfu-sion,MCAO/R)小鼠血脑屏障及其作用机制。方法采用大脑中动脉线栓法建立MCAO/R模型后,将SPF级C57BL/6(C57BL/6JNifdc)雄性小鼠,分为假手术(Sham)组、MCAO/R组、阿司匹林组(aspirin,13 mg·kg^(-1))、水蛭提取液组(leech,0.8、1.6、2.4 mL·kg^(-1))共6组。TTC染色观察脑梗死体积,mNSS评分评价神经缺损情况;HE染色及Nissl染色观察各组小鼠脑缺血半暗带病理改变;免疫荧光检测Laminin,PDGFRβ/Biotinylated LEL免疫荧光双染检测脑缺血半暗带周细胞与脑微血管内皮细胞解离情况;Western blot检测RhoA、ROCKⅡ蛋白,紧密连接相关蛋白ZO-1、Occludin、Clau-din-5,基底膜(BM)相关蛋白层粘连蛋白(LN)、纤维连接蛋白(FN)及金属基质蛋白酶MMP-2、MMP-9蛋白,以及p-MLC/MLC蛋白表达情况。结果Leech明显改善小鼠神经缺损,减轻脑梗死体积(P<0.05,P<0.01);Western blot结果显示,leech可上调ZO-1、Occludin、Claudin-5、Laminin、Fibronectin蛋白表达,降低p-MLC/MLC、RhoA、ROCKⅡ、MMP-2、MMP-9蛋白表达(P<0.05,P<0.01);免疫荧光结果显示,leech可明显提高Laminin及PDGFRβ/Biotinylated LEL免疫荧光双染的表达。结论Leech可以改善MCAO/R小鼠脑缺血半暗带BBB损伤,其机制可能是通过调节RhoA/ROCKⅡ信号通路有关。 展开更多
关键词 水蛭 脑缺血/再灌注损伤 RhoA/rockⅡ信号通路 血脑屏障 紧密连接 基质金属蛋白酶
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Quick and reliable approach for rating underground engineering rock mass based on RMR system
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作者 Peng He Zhi-kang Li +5 位作者 Feng Jiang Gang Wang Wen-peng Yuan Zheng-hu Ma Chuan-xin Yang Zihao Jiang 《Applied Geophysics》 2025年第2期447-460,559,共15页
The rock mass rating(RMR)system is one of the most commonly used methods for classifying rock masses in underground engineering.Uncertainty of RMR values can signifi cantly aff ect the safety of underground projects.I... The rock mass rating(RMR)system is one of the most commonly used methods for classifying rock masses in underground engineering.Uncertainty of RMR values can signifi cantly aff ect the safety of underground projects.In this regard,we proposed a reliable rating approach for classifying rock masses based on the reliability theory.This theory was incorporated into the RMR system to establish the functions of rock masses of different classifications.By analyzing the probability distribution patterns of various parameters used in the RMR system and using the Monte Carlo method to calculate the reliability probability of surrounding rock belonging to each classifi cation,reliable RMR values for the rock mass to be excavated can be obtained.The results demonstrate that it is feasible to adopt the reliability theory in classifi cation tasks considering the randomness characteristics of rock and soil.As verified through a case study of the Lushan Tunnel project,the proposed approach can be used to obtain the probability of the uncertainty of the calculated RMR values of underground engineering rock masses,and the calculation results are consistent with reality.The proposed approach can serve as a reference for studies in other fi elds and also applies to other rock mass classifi cation methods. 展开更多
关键词 Reliability analysis theory RMR engineering application Surrounding rock quality
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FOXK1通过上调ROCK1表达促进食管鳞状细胞癌的恶性生物学行为
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作者 武俊红 杨霞 +4 位作者 许环琛 王歆皓 胡照坤 路军涛 郭炜 《临床与实验病理学杂志》 北大核心 2026年第1期29-37,共9页
目的探讨FOXK1在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中的表达、功能及其潜在的分子调控机制。方法常规培养ESCC细胞系KYSE-150、KYSE-170和TE-1;并使用转染试剂将核酸和质粒转染至各组细胞。结合数据库分析和qRT-... 目的探讨FOXK1在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中的表达、功能及其潜在的分子调控机制。方法常规培养ESCC细胞系KYSE-150、KYSE-170和TE-1;并使用转染试剂将核酸和质粒转染至各组细胞。结合数据库分析和qRT-PCR检测FOXK1在ESCC组织和细胞中的表达;开展生物信息学分析预测下游靶基因,并以ROCK1为候选基因,采用qRT-PCR检测其表达,双荧光素酶报告实验验证FOXK1对ROCK1启动子的转录调控作用。通过平板克隆实验、划痕愈合实验及Transwell小室实验检测各组细胞的克隆形成、迁移及侵袭能力。应用qRT-PCR和Western blot法检测各组细胞中上皮-间质转化(epithelialmesenchymal transition,EMT)关键分子的表达;免疫荧光实验检测F-actin的荧光强度。结果FOXK1在ESCC组织和细胞中呈高表达,其中KYSE-150、KYSE-170和TE-1细胞的表达量分别约为正常食管上皮细胞的40.0倍、17.9倍和24.8倍(P<0.05)。ROCK1为FOXK1的潜在下游靶基因,两者表达水平呈正相关(P<0.05),且ROCK1在ESCC细胞系中亦高表达。过表达及敲低FOXK1会相应上调或下调ROCK1的表达,并证实FOXK1可结合ROCK1启动子发挥转录调控作用。功能方面,过表达FOXK1促进ESCC细胞增殖、迁移和侵袭,敲低ROCK1抑制上述表型,两者同时作用可部分逆转由FOXK1过表达所引起的促肿瘤效应。机制层面,敲低ROCK1使EMT进程关键分子CDH2、vimentin和ZEB1的mRNA及蛋白水平均下降;过表达FOXK1增强F-actin的聚合,敲低ROCK1削弱F-actin的聚合,两者同时作用可部分逆转FOXK1对F-actin的促聚合效应。结论FOXK1通过上调ROCK1的表达促进ESCC细胞的迁移和侵袭,提示FOXK1可能作为ESCC的潜在诊断和治疗靶点。 展开更多
关键词 食管肿瘤 鳞状细胞癌 FOXK1 rock1 上皮-间质转化 细胞骨架
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Synthetic metabolic engineering of functional crops:Boosting nutrition and human health 被引量:3
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作者 Nan Chai Jie Xu +12 位作者 Ruixiang Zhang Guangzhou Li Jun Wen Liying Su Yang Xue Tie Li Jialin Liu Dongchang Zeng Jiantao Tan Jiaqi Huang Letian Chen Yao-Guang Liu Qinlong Zhu 《The Crop Journal》 2026年第1期8-21,共14页
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth... A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems. 展开更多
关键词 Synthetic biology Synthetic metabolism engineering Functional crops Multigene stacking and gene editing Artificial intelligence
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A review of multiscale numerical modeling of rock mechanics and rock engineering
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作者 Xindong Wei Zhe Li Gaofeng Zhao 《Deep Underground Science and Engineering》 2025年第3期382-405,共24页
Rock is geometrically and mechanically multiscale in nature,and the traditional phenomenological laws at the macroscale cannot render a quantitative relationship between microscopic damage of rocks and overall rock st... Rock is geometrically and mechanically multiscale in nature,and the traditional phenomenological laws at the macroscale cannot render a quantitative relationship between microscopic damage of rocks and overall rock structural degradation.This may lead to problems in the evaluation of rock structure stability and safe life.Multiscale numerical modeling is regarded as an effective way to gain insight into factors affecting rock properties from a cross-scale view.This study compiles the history of theoretical developments and numerical techniques related to rock multiscale issues according to different modeling architectures,that is,the homogenization theory,the hierarchical approach,and the concurrent approach.For these approaches,their benefits,drawbacks,and application scope are underlined.Despite the considerable attempts that have been made,some key issues still result in multiple challenges.Therefore,this study points out the perspectives of rock multiscale issues so as to provide a research direction for the future.The review results show that,in addition to numerical techniques,for example,high-performance computing,more attention should be paid to the development of an advanced constitutive model with consideration of fine geometrical descriptions of rock to facilitate solutions to multiscale problems in rock mechanics and rock engineering. 展开更多
关键词 constitutive model multiscale modeling numerical method rock
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聚力食品工程前沿ENGINEERING Foods正式起航
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《中国食品学报》 北大核心 2026年第1期439-439,共1页
2026年1月27日,中国工程院在北京召开Engineering刊群建设与发展会议,正式发布了以旗舰主刊Engineering为核心、19个专业领域子刊的“1+19”工程科技期刊集群新体系,擘画出构建世界一流工程科技期刊群的宏伟蓝图。在此背景下,Engineerin... 2026年1月27日,中国工程院在北京召开Engineering刊群建设与发展会议,正式发布了以旗舰主刊Engineering为核心、19个专业领域子刊的“1+19”工程科技期刊集群新体系,擘画出构建世界一流工程科技期刊群的宏伟蓝图。在此背景下,Engineering系列子刊的新成员——ENGINEERING Foods应运而生(ISSN2097-7778)。 展开更多
关键词 期刊集群 中国工程院 engineering Foods engineering
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Zircon U-Pb ages of the volcanic rocks and their constraints on the ending of the Huoshiling Formation in the southeastern of Songliao Basin,NE China 被引量:1
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作者 Xue-jiao Qu Ming-kai Zhang +5 位作者 Pu-jun Wang Zhuo-long Yang You-feng Gao Kang-jun Wu Jia Wang Xian-feng Tan 《China Geology》 2026年第1期214-216,I0023,共4页
1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a u... 1.Objective The Songliao Basin(SB)is situated on the eastern margin of Eurasia continent(Northeast Asia).During the Late Jurassic to Early Cretaceous,hundreds of rifting basins developed in this area,and the SB is a unique case among them as it evolved into the largest rift basin.The rift basin filling of SB includes Huoshiling Formation,Shahezi Formation,and Yingcheng Formation in ascending order.The mega-rifting was controlled by the Mongol-Okhotsk Collisional Belt to the north and northwest and the Pacific Subduction Zone to the east(Wang PJ et al.,2016).As the first rifting succession,the Huoshiling Formation contains key information about the formation of the rifting basins and records the evolution of the Mongol-Okhotsk Collisional Belt and the Pacific Subduction Zone.However,the geological period of the Huoshiling Formation has not been well constrained for two main reasons.First,it is easily confused with the Yingcheng Formation,as both are dominated by volcanogenic-sedimentary successions.Second,there is lack of reliable dating samples from the uppermost part of the Huoshiling Formation due to its considerable burial depth. 展开更多
关键词 rift basin rift basinthe yingcheng formation ZIRCON U Pb ages rifting basins volcanic rocks huoshiling formationshahezi formationand
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Early Warning of Rock Collapse Based on Precursor Identification in the Detachment Phase
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作者 Yan Du Mengjia Lyu +4 位作者 Mowen Xie Yujing Jiang Santos Daniel Chicas Hongda Zhang Jingnan Liu 《Journal of Earth Science》 2026年第1期373-380,共8页
0 INTRODUCTION Due to the sudden and highly destructive nature of slope rock collapse,developing effective early warning systems has become an urgent challenge in geotechnical engineering(Cai and Detournay,2024;Loew e... 0 INTRODUCTION Due to the sudden and highly destructive nature of slope rock collapse,developing effective early warning systems has become an urgent challenge in geotechnical engineering(Cai and Detournay,2024;Loew et al.,2017).Traditional monitoring methods primarily target the acceleration stage preceding disasters(such as displacement monitoring for landslides and debris flows),which is effective for early warning of plastic collapse disasters but often inadequate for brittle failure modes(Walter et al.,2019;Chao et al.,2018;Crosta et al.,2017). 展开更多
关键词 precursor identification monitoring methods displacement monitoring geotechnical engineering cai early warning detachment phase slope rock collapsedeveloping rock collapse
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基于RhoA/ROCK1通路探讨花旗松素对缺氧/复氧诱导的心肌细胞损伤的影响
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作者 徐颖 李丽华 +1 位作者 刘晨 张宁 《河北医学》 2026年第2期240-247,共8页
目的:基于RhoA/ROCK1通路,探讨花旗松素(TAX)对缺氧/复氧(H/R)诱导的心肌细胞损伤的影响。方法:CCK-8筛选TAX处理H/R诱导H9C2的最佳浓度;H9C2细胞分为正常组、H/R组、H/R+TAX组、H/R+ROCK抑制剂(Y-27632)组、H/R+TAX+RhoA激活剂溶血磷脂... 目的:基于RhoA/ROCK1通路,探讨花旗松素(TAX)对缺氧/复氧(H/R)诱导的心肌细胞损伤的影响。方法:CCK-8筛选TAX处理H/R诱导H9C2的最佳浓度;H9C2细胞分为正常组、H/R组、H/R+TAX组、H/R+ROCK抑制剂(Y-27632)组、H/R+TAX+RhoA激活剂溶血磷脂酸(LPA)组。台盼蓝染色检测各组H9C2细胞存活率;试剂盒检测各组H9C2细胞LDH释放率;流式细胞仪和TUENL染色检测各组H9C2细胞凋亡率;DCFH-DA法和ELISA检测各组H9C2细胞氧化应激和炎症反应;Western blot检测各组H9C2细胞RhoA/ROCK1通路相关蛋白表达。结果:与对照组比较,H/R组H9C2细胞存活率明显降低(P<0.05);与H/R组比较,H/R+TAX 20μmoL/L组和H/R+TAX 40μmoL/L组H9C2细胞存活率明显升高(P<0.05);与H/R+TAX 40μmoL/L组比较,H/R+TAX 80μmoL/L组H9C2细胞存活率明显降低(P<0.05)。与对照组比较,H/R组H9C2细胞存活率、GSH-Px下调,LDH释放率、凋亡率以及TUENL阳性细胞数、ROS荧光强度、MDA、NOX4、IL-6、TNF-α、NLRP3、ICAM-1、RhoA、ROCK1、p-MLC2/MLC2上调(P<0.05);与H/R组比较,H/R+TAX组和H/R+Y-27632组H9C2细胞存活率、GSH-Px上调,LDH释放率、凋亡率以及TUENL阳性细胞数、ROS荧光强度、MDA、NOX4、IL-6、TNF-α、NLRP3、ICAM-1、ROCK1、p-MLC2/MLC2下调(P<0.05);与H/R+TAX组比较,H/R+TAX+LPA组H9C2细胞存活率、GSH-Px下调,LDH释放率、凋亡率以及TUENL阳性细胞数、ROS荧光强度、MDA、NOX4、IL-6、TNF-α、NLRP3、ICAM-1、RhoA、ROCK1、p-MLC2/MLC2上调(P<0.05)。结论:TAX通过抑制RhoA/ROCK1通路调控氧化应激、炎症反应和细胞凋亡,缓解H/R诱导的心肌细胞损伤。 展开更多
关键词 花旗松素 缺氧/复氧 心肌细胞 RhoA/rock1通路
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Exploring the thermal evolution of highly-to over-mature source rocks using Raman spectroscopy and geochemical signatures
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作者 Fu-hua Shang Xiao-peng Sun +3 位作者 Shu-wei Ma Yu-tong Pang Guan-qun Zhou Ke Miao 《China Geology》 2026年第1期75-85,共11页
This study investigated the heterogeneous responses of organic matter(OM)in highly-to over-mature source rocks during thermal maturation.An integrated analysis was conducted on the Raman spectroscopic and geochemical ... This study investigated the heterogeneous responses of organic matter(OM)in highly-to over-mature source rocks during thermal maturation.An integrated analysis was conducted on the Raman spectroscopic and geochemical signatures of shales from the Lower Silurian Longmaxi Formation and the Lower Cambrian Qiongzhusi Formation,as well as anthracites from the Lower Permian Shanxi–Formation and the Upper Carboniferous Taiyuan Formation(collectively referred to as the Shanxi Taiyuan Formations).Additionally,burial and thermal evolution modeling was employed to support the analysis.A systematic assessment of Raman spectral parameters(e.g.,the positions and intensity ratio of the D and G bands)revealed robust correlations between the thermal history patterns of source rocks and molecular structural evolution parameters.The subsequent mechanistic quantification demonstrated that the maturation state of the source rocks was subjected to the hierarchical control of three principal factors:Peak heating temperature,the duration of sustained thermal intensity,and effective maturation duration.In addition,comparative analyses demonstrated that the anthracites attained higher structural ordering under sustained thermal conditions.This contrasts with the disordered carbon matrices observed in the intermittently heated shales.Raman spectroscopy further revealed broader variations in the D and G band intensities of the Longmaxi Formation compared to the Qiongzhusi Formation.This difference is associated with their different thermal histories.The thermal burial histories confirm that shales in the Longmaxi Formation underwent thermal exposure at lower peak temperatures over a shorter duration compared to those in the Qiongzhusi Formation.Finally,this study established a maturity calibration model for over-mature source rocks through a systematic correlation between Raman peak height ratios(R_(D/G))and vitrinite reflectance(R_(o)). 展开更多
关键词 Raman spectroscopy Overmature source rock Qiongzhusi Formation Longmaxi Formation ANTHRACITE Mineral exploration engineering
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Cerchar abrasivity test and its applications in rock engineering:A review
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作者 Guangzhe Zhang Kurosch Thuro +2 位作者 Zhengyang Song Wengang Dang Qingsheng Bai 《International Journal of Coal Science & Technology》 2025年第1期1-42,共42页
Abrasiveness as an intrinsic property of rocks defines the extent of wear or loss when interacting with other materials.In engineering sectors like hard rock mining and tunnelling,comprehending rock abrasiveness holds... Abrasiveness as an intrinsic property of rocks defines the extent of wear or loss when interacting with other materials.In engineering sectors like hard rock mining and tunnelling,comprehending rock abrasiveness holds paramount importance due to its direct effect on tool wear during excavation.Among the diverse methods for assessing rock abrasiveness,the Cerchar abrasivity test emerges as the most widely used approach.Over time,the Cerchar test has garnered substantial attention from scholars,who have delved into the factors influencing test results due to testing conditions and examined the connection between the physical-mechanical parameters of rocks and their abrasiveness.Recent advancements in testing instrument have expanded our ability to measure additional parameters during rock cutting or drilling,yielding fresh insights for abrasiveness assessment,tool wear prediction,tool performance evaluation and rock excavatability estimation.The Cerchar abrasivity test,coupled with recent developments in testing instrument and parameter measurement,holds promising potential for enhancing our comprehension of rock abrasiveness and its practical implications.This review systematically traces the evolution of the test.It commences with an overview of the test origin and progression,emphasizing its pivotal role in assessing rock abrasiveness.Furthermore,it consolidates and categorizes the research contributions from various scholars regarding the test.This includes enhancements and refinements of the testing apparatus,as well as investigations into various testing orientations and their effects on different types of rocks.Moreover,this review illuminates the broader applications and interdisciplinary possibilities of this test,not only in material science but also in tribology.It underscores how the insights gleaned from the Cerchar test can be extrapolated to diverse areas of research beyond the scope of rock engineering. 展开更多
关键词 Cerchar abrasivity Cutting/drilling efficiency rock excavatability Scratch test Tool wear/performance
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Coupled creep-damage and plastic softening/hardening model:Development and engineering application in soft-hard interlayered rock mass
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作者 WANG Yu MAO Suhui +1 位作者 DENG Huafeng CHEN Tao 《Journal of Mountain Science》 2025年第10期3913-3930,共18页
Existing creep constitutive models rarely incorporate studies on the coupling mechanism between creep damage and rock strain softening/hardening.This study analyzed the strain softening and hardening behaviors of argi... Existing creep constitutive models rarely incorporate studies on the coupling mechanism between creep damage and rock strain softening/hardening.This study analyzed the strain softening and hardening behaviors of argillaceous sandstone and sandy mudstone during load-induced failure based on the plastic increment theory.These behaviors were then coupled with an improved Burgers creep model to establish a coupled creep-damage and plastic softening/hardening model.Finally,the validity and engineering applicability of the proposed model were verified through FLAC~(3D)numerical simulations.The numerical simulation results of standard cylindrical specimens show that the established coupling model can effectively reflect the unloading creep deformation law and failure characteristics of argillaceous sandstone and sandy mudstone.Taking the diversion tunnel of a hydropower station in Northwest China as an example for engineering application,the coupled creep-damage and plastic softening/hardening model is introduced into FLAC~(3D)to carry out numerical simulation calculation of the tunnel under excavation and unsupported creep conditions.The results show that the uncoordinated deformation of the upper and lower walls of the surrounding rock of the tunnel is more prominent.When the buried depth of the tunnel increases to 80 m,the monitoring point C in the sandy mudstone area of the upper wall shows nonlinear accelerated deformation under unsupported creep conditions,and the maximum displacement in the horizontal direction reaches 44.5 mm,and the maximum displacement in the vertical direction reaches 53.5 mm.The coupled creep-damage and plastic softening/hardening model established in the research results can well describe the whole process of uncoordinated deformation and failure in the unloading creep process of soft-hard interbedded rock mass. 展开更多
关键词 Unloading creep Strain softening/hardening Creep constitutive model engineering applications
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