With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold ...With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.展开更多
In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of p...In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.展开更多
Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ...Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.展开更多
Casing deformation affects the implementation of stimulation and development measures of oilfields directly;however, the reshaping forceand torque usually are determined by experience when the deformed casing is repai...Casing deformation affects the implementation of stimulation and development measures of oilfields directly;however, the reshaping forceand torque usually are determined by experience when the deformed casing is repaired with the spinning reshaping technology;if the repairingforce or torque is too large, it will result in the damage of casing and cement sheath as well as sticking accident. So, the collapse experimentswere performed on the YAW-200 pressure testing machine by using one production casing which is often used in the oilfield and then thereshaping test of deformed casing (C110) was performed in turn by using two spinning casing swages of which the diameter is 126 mm and129 mm respectively. The continuous rotator and thrust bearing were used to provide the torque and reshaping force respectively in the repairingprocess. The reshaping force and torque required to reshape the deformed casing, the deformation law and the springback value of deformedcasing were obtained. Test results show that the diameter differential between the two spinning casing swages is reasonable. Furthermore, inorder to ensure the safety and reliability of the implementation of post-production technologies, the mechanical properties of deformed casingbefore and after reshaping were tested. It was found that all the mechanical parameters of the deformed casing after reshaping reduced, whichresulted in the decrease of the strength of the reshaped casing. These research achievements would provide important experimental data inoptimizing the structure and construction parameters of spinning casing swages.展开更多
This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical ...This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.展开更多
An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this pa...An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.展开更多
The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA an...The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.展开更多
The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequen...The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequences,some residues werechanged and the reshaping VL and VH genes were designed.The full VH gene was assem-bled in three steps with eight chemically synthesized oligonucleotide fragments using over-lapping PCR and sequenced.The VH gene was expressed as active protein and inclusion bod-ies in the vectors of pCOMB3 and pGEX-4T-1 by ELISA and Western blot analysis.展开更多
The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through indust...The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through industrial depression and weakening growth momentum caused by the large urbanization costs; （2） the subordination of service sector as a result of nearly irreversibly industrial professional, which falters the process of service sector transition and upgrading,＂ （3） inefficient knowledge production allocation and human capital upgrade due to the absence of incentivized compensation of knowledge consumption. We suggest that a country should reshape its efficiency model by upgrading knowledge factor and human capital as the pre-requisite. Given the dilemmas of transition, China should take the faetorization trend of service sector and reshape efficiency model through institutional reform, ensuring that service sector will develop in tandem with industrial sector.展开更多
The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism a...The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism and populism,the resurgent power politics and authoritarianism,theintensified competition in geopolitical and other new areas,and the incessant regional turmoil and conflicts.展开更多
Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,ai...Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,aiming to reshape the economic geography of China.This paper is based on the Belt and Road Initiative and the Yangtze River Economic Belt and outlines the pattern of opening up.To analyze the impact of the pattern of opening up on the regional integration of China's economic geography,this paper has developed a new economic geography model comprised of four regions and two countries.From this,it draws some conclusions.First,the change of pattern of opening up will lead to shifting centripetal and centrifugal forces from the international market.The greater the scale of neighboring markets,the stronger the agglomeration force will be; the more product varieties made in neighboring countries,the more potent its dispersion force.Second,developing an inland international trade corridor will decentralize industry distribution and reduce the impact of external market integration on home countries.Third,the inland international trade corridor could alter the effect of domestic market integration on the economic geography.When domestic integration occurs prior to international integration,further integration of a domestic market leads to greater industrial distribution along a bell-shaped curve,which describes economic activities from dispersion to agglomeration to decentralization.Therefore,developing an integrated market system of major countries and opening a corridor between China and Europe is not only the key to reshaping China's economic geography but also the path to solving the problems of the Heihe-Tengchong Line.展开更多
Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often o...Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often overlooking the revolutionary nature of digital media.Digital media has the sweeping potential to unify all forms of media and reshape social life,giving rise to new demands for a new generation of human rights.The concept of digital human rights can be defined as the legitimate rights of human's infinitely extended personalities through digital media.Its core characteristic is its transcendency,where every person lives in a networked space that surpasses physical boundaries,nations,and individual personalities.Human rights are generally considered the foundation for basic constitutional rights,which,in turn,form the basis for legislative acts across various sectors.In recent years,China has enacted numerous laws in the digital domain to keep pace with the times,but due to the lack of guidance on digital human rights,these laws tend to be fragmented and disjointed.It is urgent to unify digital legislation at all levels on the basis of reshaping basic constitutional rights.Thus,it is essential to reshape the basic rights based on the concept and characteristics of digital human rights and streamline legislation at all levels under the unified guidance of basic rights.This can help establish a comprehensive digital human rights protection system that meets the demands of the modern era.展开更多
The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensify...The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.展开更多
DNA,which carries genetic information,is exposed to endogenous and exogenous factors,leading to the formation of DNA lesions.To prevent the accumulation of deleterious damage that drives mutations and chromosomal rear...DNA,which carries genetic information,is exposed to endogenous and exogenous factors,leading to the formation of DNA lesions.To prevent the accumulation of deleterious damage that drives mutations and chromosomal rearrangements,several specific DNA repair pathways are mobilized.Most of these DNA repair pathways are DNA synthesis-dependent processes that function efficiently within different chromatin states(Dabin et al.,2023).展开更多
In recent years, high-frequency resonance (HFR) events occurred in several modular multilevel converter based high-voltage direct current (MMC-HVDC) projects. The time delay of an MMC-HVDC system is the critical facto...In recent years, high-frequency resonance (HFR) events occurred in several modular multilevel converter based high-voltage direct current (MMC-HVDC) projects. The time delay of an MMC-HVDC system is the critical factor that induces HFR. The frequency coupling affects the impedance characteristics of an MMC and further deteriorates system stability. Therefore, in this paper, a multi-input multi-output admittance model of an MMC-HVDC system is developed to analyze its frequency characteristics. The effects of current loop, power loop, phase-locked loop, and operating point on the MMC frequency coupling degree are analyzed in detail. Meanwhile, to further suppress HFR in the MMC-HVDC system, an enhanced impedance reshaping control strategy based on the equivalent single-input single-output impedance model is proposed. Finally, the accuracy of the enhanced impedance model and the effectiveness of the impedance reshaping control are verified by electromagnetic transient simulations in PSCAD.展开更多
In this article, we review on narrowband photon pairs produced in nonlinear crystals, and especially in atomic ensembles. In atomic ensembles, ＂write-read＂ process in pulse mode and spontaneous four-wave mixing proc...In this article, we review on narrowband photon pairs produced in nonlinear crystals, and especially in atomic ensembles. In atomic ensembles, ＂write-read＂ process in pulse mode and spontaneous four-wave mixing process （SFWM） in continuous mode are two popular photon pair generation schemes. We specifically discuss the experimental works with continuous SFWM scheme in cold atomic ensembles. Photon pairs produced in these systems are characteristic of controllable long coherence time, and therefore are accessible with direct temporal modulation. We elaborate on the recent techniques on modulation and waveform reshaping of narrow-band paired photons.展开更多
Two vectors, pWA180 and pROH80, for expression of single-chain Fv fragments (ScFv) were con-siruciea. (?)ne anti-CD3 VH and VL genes were amplified from UCHTl cells by RT-PCR and sequenced. Both genes were cloned in p...Two vectors, pWA180 and pROH80, for expression of single-chain Fv fragments (ScFv) were con-siruciea. (?)ne anti-CD3 VH and VL genes were amplified from UCHTl cells by RT-PCR and sequenced. Both genes were cloned in pWA180 to express native ScFv and pROH80 for GST-ScFv fusion protein expression. The expression products were analysed by ELISA and Western blot. The combining site of OKT3 was modeled. Human [g LS1 and Nd were selected as acceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3. By com-paring OKT3, LS1 and Nd with their own family sequences, some residues were changed and the reshaping VL and VH genes were designed. The full VH gene was assembled in three steps with eight chemically synthesized oligonu-cleotide fragments using overlapping PCR and sequenced. The VH gene was expressed as active protein in pCOMB3 and as inclusion bodies in pGEX-4T-l by ELISA and Western blot analysis.展开更多
Localized surface plasmon resonances(LSPRs)in metal nanostructures have been a central subject of nano-photonics due to their ability to manipulate light beyond the optical diffraction limit.Nevertheless,the large int...Localized surface plasmon resonances(LSPRs)in metal nanostructures have been a central subject of nano-photonics due to their ability to manipulate light beyond the optical diffraction limit.Nevertheless,the large intrinsic dissipations of LSPRs have severely hindered their applications,so the on-demand control of the LSPR modes is highly desired and remains open yet.Here,we experimentally and theoretically demonstrate that the plasmon mode can be effectively engineered by interacting with constructive or destructive modes supported by film interference.When a metal nanoparticle interacts with a constructive mode,the dissipation linewidth of its LSPR mode shows a significant reduction of 58%.Simultaneously,the scattering intensity is remarkably enhanced,in vast favor of measuring weak signals from small nanoparticles.Furthermore,the film-destructiveinterference splitting in the scattering spectrum by weak coupling,rather than strong coupling,is revealed if the plasmon particles interact with the destructive mode,resulting in two new hybrid plasmon modes with narrow linewidths.The effective polarizability model of reshaping the LSPR modes by the film interference is present to well understand the experimental observations.Our work may pave the way toward low-loss plasmonic photonics and its practical applications.展开更多
Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to...Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to 28 ps is achieved.展开更多
文摘With accelerated expansion,the Shanghai Cooperation Organization(SCO)has extended its geographical reach to the vast Eurasian region,where the balance of power has undergone profound changes since the end of the Cold War,showing instability and uncertainty.The type of order that can emerge in a region depends on the effectiveness of governance and the power structures and systems built upon it.The SCO advocates a brand new philosophy of cooperation that transcends the traditional mentality of international relations,forging a new model of multilateral collaboration.The SCO has vigorously participated in improving regional governance and is thus playing an increasingly important and unique role in reshaping the Eurasian regional order.
基金Sponsored by the General Project of the National Social Science Foundation of China(25BGL309).
文摘In this paper,through a methodology combining theoretical research and field investigation,the project of urban renewal at Xidan Renewal Site in Beijing was studied from the aspects of data analysis,investigation of people’s behaviors,measurement of its scale,and architectural history.Besides,how urban renewal creates new urban vitality was demonstrated.It has certain guiding and reference significance for research on urban renewal.Remarkable results have been achieved,such as rationalizing the internal functions of old residential areas,improving circulation experience conditions,and promoting and recreating unique cultural features.It is a case of engineering innovation in urban renewal in the core areas of domestic cities.
基金financially supported by the National Natural Science Foundation of China (51674088)Natural Science Foundation of Heilongjiang Province of China (LH 2021E011)。
文摘Hydraulic rolling reshaper is an advanced reshaping tool to solve the problem of casing deformation,which has been widely used in recent years.When it is used for well repair operation,the reshaping force provided by ground devices is generally determined by experience.However,too large reshaping force may destroy the deformed casing,and too small reshaping force may also prolong the construction period and affect the repairing effect.In this paper,based on Hertz contact theory and elastic-plastic theory,combined with the process parameters of shaping,and considering the structural characteristics of the deformed casing and reshaper,we propose a mathematical model for calculating the reshaping force required for repairing deformed casing by hydraulic rolling reshaper.Meanwhile,the finite element model and numerical method of hydraulic rolling reshaper repairing deformed casing are established by using the finite element method,and the reliability of the mathematical model is verified by several examples.On this basis,the control variable method is used to investigate the influence of each parameter on the reshaping force,and the influence degree of each parameter is explored by orthogonal simulation test and Pearson correlation analysis.The research results not only provide an important theoretical basis for the prediction of reshaping force in on-site construction,but also provide a reference for the subsequent improvement of the shaping process.
文摘Casing deformation affects the implementation of stimulation and development measures of oilfields directly;however, the reshaping forceand torque usually are determined by experience when the deformed casing is repaired with the spinning reshaping technology;if the repairingforce or torque is too large, it will result in the damage of casing and cement sheath as well as sticking accident. So, the collapse experimentswere performed on the YAW-200 pressure testing machine by using one production casing which is often used in the oilfield and then thereshaping test of deformed casing (C110) was performed in turn by using two spinning casing swages of which the diameter is 126 mm and129 mm respectively. The continuous rotator and thrust bearing were used to provide the torque and reshaping force respectively in the repairingprocess. The reshaping force and torque required to reshape the deformed casing, the deformation law and the springback value of deformedcasing were obtained. Test results show that the diameter differential between the two spinning casing swages is reasonable. Furthermore, inorder to ensure the safety and reliability of the implementation of post-production technologies, the mechanical properties of deformed casingbefore and after reshaping were tested. It was found that all the mechanical parameters of the deformed casing after reshaping reduced, whichresulted in the decrease of the strength of the reshaped casing. These research achievements would provide important experimental data inoptimizing the structure and construction parameters of spinning casing swages.
基金supported by the National Natural Science Foundation of China (Nos. 11402020 and 51407011)
文摘This study presents a novel impact time and angle constrained guidance law for homing missiles. The guidance law is first developed with the prior-assumption of a stationary target, which is followed by the practical extension to a maneuvering target scenario. To derive the closed-form guidance law, the trajectory reshaping technique is utilized and it results in defining a specific polynomial function with two unknown coefficients. These coefficients are determined to satisfy the impact time and angle constraints as well as the zero miss distance. Furthermore, the proposed guidance law has three additional guidance gains as design parameters which make it possible to adjust the guided trajectory according to the operational conditions and missile's capability. Numerical simulations are presented to validate the effectiveness of the proposed guidance law. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
基金the National Natural Science Foundation of China(Nos.11772293 and12072312)Zhejiang Science and Technology Project(No.2019C03129)。
文摘An actual ecological predator-prey system often undergoes random environmental mutations owing to the impact of natural disasters and man-made destruction, which may destroy the balance between the species. In this paper,the stochastic dynamics of the nonlinear predator-prey system considering random environmental mutations is investigated, and a feedback control strategy is proposed to reshape the response of the predator-prey system against random abrupt environmental mutations. A delayed Markov jump system(MJS) is established to model such a predator-prey system. A novel first integral is constructed which leads to better approximation solutions of the ecosystem. Then, by applying the stochastic averaging method based on this novel first integral, the stochastic response of the predator-prey system is investigated, and an analytical feedback control is designed to reshape the response of the ecosystem from the disturbed state back to the undisturbed one.Numerical simulations finally illustrate the accuracy and effectiveness of the proposed procedure.
基金Supported by the NSFC-Zhejiang Joint Fund for the Integration of Industrialization and Informatization(No.U1809212)the Scientific and Technical Project of Zhejiang Province(Nos.2021C02055,2017C02013)+1 种基金the National Natural Science Foundation of China(No.31272642)the Healthy Aquaculture,the K.C.Wong Magna Fund in Ningbo University,and the Collaborative Innovation Center for Zhejiang Marine High-efficiency。
文摘The homodimeric kinesin-2 protein KIF17 functions in intracellular transport and spermiogenesis in mammals.However,its role in fish spermiogenesis has not been reported.Here,we aimed to clone full-length kif17 cDNA and determine the molecular characteristics and expression patterns of KIF17 in Larimichthys polyactis spermiogenesis.The full-length cDNA of L.polyactis kif17(Lp-kif17)was sequenced and found to contain a 332-bp 5′untranslated region,480-bp 3′untranslated region,and 2433-bp open reading frame encoding 810 amino acids.Bioinformatics analyses showed that L.polyactis KIF17(Lp-KIF17)shared high sequence similarity with homologs in other animals and possessed an N-terminal motor domain with microtubule-binding sites and adenosine triphosphate(ATP)hydrolysis sites,a stalk domain containing two coiled-coil regions,and a C-terminal tail domain.The Lp-kif17 mRNA was widely expressed in various tissues,with the highest level in the brain,followed by that in the testis.Fluorescence in situ hybridization(FISH)analysis revealed that Lp-kif17 was continuously expressed in spermiogenesis,showing that it had potential functions in this process.Using immunofluorescence(IF)analysis,we found that Lp-KIF17 colocalized with tubulin and was transferred from the perinuclear cytoplasm to the side of spermatid where the tail forms during spermiogenesis.These findings suggested that KIF17 is involved in L.polyactis spermiogenesis.In particular,it may participate in nuclear shaping and tail formation by interacting with perinuclear microtubules during spermatid reshaping.In addition to providing evidence for the role of KIF17 in fish spermatid reshaping,this study provides important data for studies of reproductive biology in L.polyactis.
基金Supported by National Natural Science Foundation of Chinathe High Technology Research and Development Programme of China.
文摘The combining site of OKT3 was modeled,and Human Ig LS1 and ND were selected asacceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3.Bycomparing OKT3,LS1 and ND,with their own family sequences,some residues werechanged and the reshaping VL and VH genes were designed.The full VH gene was assem-bled in three steps with eight chemically synthesized oligonucleotide fragments using over-lapping PCR and sequenced.The VH gene was expressed as active protein and inclusion bod-ies in the vectors of pCOMB3 and pGEX-4T-1 by ELISA and Western blot analysis.
基金sponsored by major tendering projects of National Social Sciences Foundation "Study on Accelerating Economic Adjustment and Coordinated Development"(Grant No.12&ZD084) and "Study on Contribution of Consumption to Economic Growth under Shifting Demand Structure"(Grant No.15ZDC011)projects of National Social Sciences Foundation "Study on China's Structural Growth Deceleration,Transition Risks and Efficiency Improvement Path"(Grant No.14AJL006) and "Study on the Scale,Spatial Clustering and Management Model of Chinese Cities"(Grant No.15ZDC011)
文摘The transition from middle-income to high-income stage is fraught with risks of growth divergence. Economic transition is clouded by the following possibilities： （1）falling share of industrial seetor through industrial depression and weakening growth momentum caused by the large urbanization costs; （2） the subordination of service sector as a result of nearly irreversibly industrial professional, which falters the process of service sector transition and upgrading,＂ （3） inefficient knowledge production allocation and human capital upgrade due to the absence of incentivized compensation of knowledge consumption. We suggest that a country should reshape its efficiency model by upgrading knowledge factor and human capital as the pre-requisite. Given the dilemmas of transition, China should take the faetorization trend of service sector and reshape efficiency model through institutional reform, ensuring that service sector will develop in tandem with industrial sector.
文摘The global security situation in 2018 continued with its recent years of complexity and volatility,with its order and rules challenged by the prevailing unilateralism and trade protectionism,the emerging nationalism and populism,the resurgent power politics and authoritarianism,theintensified competition in geopolitical and other new areas,and the incessant regional turmoil and conflicts.
基金a staged research result of "Studies on New Strategic Regions Contributing to China’s Economic Growth in the Future"(14ZDA024)a major program of the National Social Science Fund of China+3 种基金"Studies on Regional Integration and Welfare Compensation on the Basis of Dynamic CGE and DCI Models"(71173101)a program funded by the National Natural Science Foundation of China"Studies on Path and Mechanism to Improve Economic Performance and Quality in Jiangsu Province from the Perspective of the Supply Side"(BRA2017358)a Jiangsu "333" High-level Cultivation Program
文摘Since the 18 th National Congress of the Communist Party of China,the central government has implemented several regional development plans,including the Belt and Road Initiative and the Yangtze River Economic Belt,aiming to reshape the economic geography of China.This paper is based on the Belt and Road Initiative and the Yangtze River Economic Belt and outlines the pattern of opening up.To analyze the impact of the pattern of opening up on the regional integration of China's economic geography,this paper has developed a new economic geography model comprised of four regions and two countries.From this,it draws some conclusions.First,the change of pattern of opening up will lead to shifting centripetal and centrifugal forces from the international market.The greater the scale of neighboring markets,the stronger the agglomeration force will be; the more product varieties made in neighboring countries,the more potent its dispersion force.Second,developing an inland international trade corridor will decentralize industry distribution and reduce the impact of external market integration on home countries.Third,the inland international trade corridor could alter the effect of domestic market integration on the economic geography.When domestic integration occurs prior to international integration,further integration of a domestic market leads to greater industrial distribution along a bell-shaped curve,which describes economic activities from dispersion to agglomeration to decentralization.Therefore,developing an integrated market system of major countries and opening a corridor between China and Europe is not only the key to reshaping China's economic geography but also the path to solving the problems of the Heihe-Tengchong Line.
基金phased result of“Feasibility Demonstration of Basic Legislation on Artificial Intelligence”(Project No.2022K20263)a project of the Bureau of Law-based Cyberspace Governance at the Cyberspace Administration of China。
文摘Whether a new generation of human rights emerges in the digital age has sparked widespread debate.Academic understanding of digital technology remains confined to thinking about network technology and products,often overlooking the revolutionary nature of digital media.Digital media has the sweeping potential to unify all forms of media and reshape social life,giving rise to new demands for a new generation of human rights.The concept of digital human rights can be defined as the legitimate rights of human's infinitely extended personalities through digital media.Its core characteristic is its transcendency,where every person lives in a networked space that surpasses physical boundaries,nations,and individual personalities.Human rights are generally considered the foundation for basic constitutional rights,which,in turn,form the basis for legislative acts across various sectors.In recent years,China has enacted numerous laws in the digital domain to keep pace with the times,but due to the lack of guidance on digital human rights,these laws tend to be fragmented and disjointed.It is urgent to unify digital legislation at all levels on the basis of reshaping basic constitutional rights.Thus,it is essential to reshape the basic rights based on the concept and characteristics of digital human rights and streamline legislation at all levels under the unified guidance of basic rights.This can help establish a comprehensive digital human rights protection system that meets the demands of the modern era.
文摘The world today is undergoing accelerated transformations unseen in a century.The international environment,fluid and volatile,is evolving in multiple dimensions beyond time and space.Faced with emerging and intensifying global challenges in the security,political,economic,technological and other fields,the international community has a pressing need to reshape the international landscape at this critical moment of change.
基金supported by the GDR EPIPLANT and the French National ResearchAgency(ANR-20-CE20-0021and ANR-24-CE20-2108).
文摘DNA,which carries genetic information,is exposed to endogenous and exogenous factors,leading to the formation of DNA lesions.To prevent the accumulation of deleterious damage that drives mutations and chromosomal rearrangements,several specific DNA repair pathways are mobilized.Most of these DNA repair pathways are DNA synthesis-dependent processes that function efficiently within different chromatin states(Dabin et al.,2023).
基金supported by National Natural Science Foundation of China(No.52277102)。
文摘In recent years, high-frequency resonance (HFR) events occurred in several modular multilevel converter based high-voltage direct current (MMC-HVDC) projects. The time delay of an MMC-HVDC system is the critical factor that induces HFR. The frequency coupling affects the impedance characteristics of an MMC and further deteriorates system stability. Therefore, in this paper, a multi-input multi-output admittance model of an MMC-HVDC system is developed to analyze its frequency characteristics. The effects of current loop, power loop, phase-locked loop, and operating point on the MMC frequency coupling degree are analyzed in detail. Meanwhile, to further suppress HFR in the MMC-HVDC system, an enhanced impedance reshaping control strategy based on the equivalent single-input single-output impedance model is proposed. Finally, the accuracy of the enhanced impedance model and the effectiveness of the impedance reshaping control are verified by electromagnetic transient simulations in PSCAD.
文摘In this article, we review on narrowband photon pairs produced in nonlinear crystals, and especially in atomic ensembles. In atomic ensembles, ＂write-read＂ process in pulse mode and spontaneous four-wave mixing process （SFWM） in continuous mode are two popular photon pair generation schemes. We specifically discuss the experimental works with continuous SFWM scheme in cold atomic ensembles. Photon pairs produced in these systems are characteristic of controllable long coherence time, and therefore are accessible with direct temporal modulation. We elaborate on the recent techniques on modulation and waveform reshaping of narrow-band paired photons.
基金Project supported by the National Natural Science Foundation of China and "863" Plan.
文摘Two vectors, pWA180 and pROH80, for expression of single-chain Fv fragments (ScFv) were con-siruciea. (?)ne anti-CD3 VH and VL genes were amplified from UCHTl cells by RT-PCR and sequenced. Both genes were cloned in pWA180 to express native ScFv and pROH80 for GST-ScFv fusion protein expression. The expression products were analysed by ELISA and Western blot. The combining site of OKT3 was modeled. Human [g LS1 and Nd were selected as acceptors of CDRs of OKT3 VL and VH to construct a reshaping antibody against CD3. By com-paring OKT3, LS1 and Nd with their own family sequences, some residues were changed and the reshaping VL and VH genes were designed. The full VH gene was assembled in three steps with eight chemically synthesized oligonu-cleotide fragments using overlapping PCR and sequenced. The VH gene was expressed as active protein in pCOMB3 and as inclusion bodies in pGEX-4T-l by ELISA and Western blot analysis.
基金supported by the National Key R&D Program of China(Grant No.2021YFA1400800)the Key-Area Research and Development Program of Guangdong Province(Grant No.2018B030329001)+1 种基金the Guangdong Special Support Program(Grant No.2019JC05X397)the Key Project of Natural Science Foundation of Henan(Grant No.232300421141)。
文摘Localized surface plasmon resonances(LSPRs)in metal nanostructures have been a central subject of nano-photonics due to their ability to manipulate light beyond the optical diffraction limit.Nevertheless,the large intrinsic dissipations of LSPRs have severely hindered their applications,so the on-demand control of the LSPR modes is highly desired and remains open yet.Here,we experimentally and theoretically demonstrate that the plasmon mode can be effectively engineered by interacting with constructive or destructive modes supported by film interference.When a metal nanoparticle interacts with a constructive mode,the dissipation linewidth of its LSPR mode shows a significant reduction of 58%.Simultaneously,the scattering intensity is remarkably enhanced,in vast favor of measuring weak signals from small nanoparticles.Furthermore,the film-destructiveinterference splitting in the scattering spectrum by weak coupling,rather than strong coupling,is revealed if the plasmon particles interact with the destructive mode,resulting in two new hybrid plasmon modes with narrow linewidths.The effective polarizability model of reshaping the LSPR modes by the film interference is present to well understand the experimental observations.Our work may pave the way toward low-loss plasmonic photonics and its practical applications.
文摘Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to 28 ps is achieved.
