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Transmission patterns of progressive damage and reliability analysis of reservoir-induced landslides considering local tensile failure
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作者 Minghao Miao Huiming Tang +5 位作者 Yinlong Jiang Kun Fang Changdong Li Cheng He Peng Cao Sha Lu 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期913-931,共19页
Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the ten... Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk. 展开更多
关键词 reliability analysis Tensile failure Reservoir landslide Progressive damage Failure mode Tensile crack
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Structural Reliability Analysis Based on Differential Evolution Algorithm and Hypersphere Integration
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作者 CHEN Zhenzhong HAN Zhuo +4 位作者 WANG Peiyu PAN Qianghua LI Xiaoke GAN Xuehui CHEN Ge 《Journal of Donghua University(English Edition)》 2026年第1期118-130,共13页
In reliability analyses,the absence of a priori information on the most probable point of failure(MPP)may result in overlooking critical points,thereby leading to biased assessment outcomes.Moreover,second-order relia... In reliability analyses,the absence of a priori information on the most probable point of failure(MPP)may result in overlooking critical points,thereby leading to biased assessment outcomes.Moreover,second-order reliability methods exhibit limited accuracy in highly nonlinear scenarios.To overcome these challenges,a novel reliability analysis strategy based on a multimodal differential evolution algorithm and a hypersphere integration method is proposed.Initially,the penalty function method is employed to reformulate the MPP search problem as a conditionally constrained optimization task.Subsequently,a differential evolution algorithm incorporating a population delineation strategy is utilized to identify all MPPs.Finally,a paraboloid equation is constructed based on the curvature of the limit-state function at the MPPs,and the failure probability of the structure is calculated by using the hypersphere integration method.The localization effectiveness of the MPPs is compared through multiple numerical cases and two engineering examples,with accuracy comparisons of failure probabilities against the first-order reliability method(FORM)and the secondorder reliability method(SORM).The results indicate that the method effectively identifies existing MPPs and achieves higher solution precision. 展开更多
关键词 reliability analysis design point positioning differential evolution algorithm hypersphere integration
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Combined Fault Tree Analysis and Bayesian Network for Reliability Assessment of Marine Internal Combustion Engine
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作者 Ivana Jovanović Çağlar Karatuğ +1 位作者 Maja Perčić Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期239-258,共20页
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ... This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels. 展开更多
关键词 Fault tree analysis Bayesian network reliability REDUNDANCY Internal combustion engine
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Failure Modes and Reliability Analysis of Autonomous Underwater Vehicles–A Review
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作者 Yunsai Chen Qiangguo Niu +5 位作者 Zengkai Liu Boyuan Huang Tianyu Xie Liujun Zhong Danyang Wan Zheng Wang 《哈尔滨工程大学学报(英文版)》 2025年第5期900-924,共25页
Autonomous Underwater Vehicles(AUVs)are pivotal for deep-sea exploration and resource exploitation,yet their reliability in extreme underwater environments remains a critical barrier to widespread deployment.Through s... Autonomous Underwater Vehicles(AUVs)are pivotal for deep-sea exploration and resource exploitation,yet their reliability in extreme underwater environments remains a critical barrier to widespread deployment.Through systematic analysis of 150 peer-reviewed studies employing mixed-methods research,this review yields three principal advancements to the reliability analysis of AUVs.First,based on the hierarchical functional division of AUVs into six subsystems(propulsion system,navigation system,communication system,power system,environmental detection system,and emergency system),this study systematically identifies the primary failure modes and potential failure causes of each subsystem,providing theoretical support for fault diagnosis and reliability optimization.Subsequently,a comprehensive review of AUV reliability analysis methods is conducted from three perspectives:analytical methods,simulated methods,and surrogate model methods.The applicability and limitations of each method are critically analyzed to offer insights into their suitability for engineering applications.Finally,the study highlights key challenges and research hotpots in AUV reliability analysis,including reliability analysis under limited data,AI-driven reliability analysis,and human reliability analysis.Furthermore,the potential of multi-sensor data fusion,edge computing,and advanced materials in enhancing AUV environmental adaptability and reliability is explored. 展开更多
关键词 Autonomous underwater vehicles reliability analysis Failure modes classification Human reliability analysis AI-based reliability analysis Literature review
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Reliability analysis of soil slopes stabilized with piles under rainfall
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作者 Xiangyu Ma Yuanyuan Tao +2 位作者 Meng Lu Atma Sharma Jie Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第11期6951-6963,共13页
Reliability analysis of soil slopes under rainfall is an important task for landslide risk assessment.Previous studies rarely contribute to the probabilistic analysis of slope stability under rainfall with reinforceme... Reliability analysis of soil slopes under rainfall is an important task for landslide risk assessment.Previous studies rarely contribute to the probabilistic analysis of slope stability under rainfall with reinforcement.A new method is suggested for reliability analysis of soil slopes stabilized with piles under rainfall.First,an efficient numerical model is exploited for slope stability analysis,where two types of slope failure modes,i.e.,plastic flow and local failure are considered.To address the blocking effect of piles during seepage analysis,the equivalent hydraulic conductivity of the pile area is estimated according to the effective medium theory.The stabilizing force of piles is investigated by an analytical approach.For saving computational effort,the response surface is established based on a multi-class classification model to predict two types of slope failure modes.Finally,uncertainties in soil parameters and rainfall events are both modelled,and the failure probability of soil slopes within a given time period is assessed through Monte Carlo simulation.An illustrative example is used to demonstrate the performance of the suggested method.It is found that the slope is mainly controlled by local failure.As the pile spacing increases,the likelihood of plastic flow significantly increases.As the piles are located near the slope crest,plastic flow is effectively prevented and the slope is better stabilized against rainfall.If rainfall uncertainties are not considered,the slope failure probability is significantly overestimated.Overall,this study can provide a useful guidance for the design of pile-stabilized slopes against rainfall infiltration. 展开更多
关键词 Soil slopes PILES RAINFALL UNCERTAINTIES reliability analysis
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Reliability analysis of modular charge swinging-loading positioning accuracy under new failure criterion based on spatial geometric relationship
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作者 Zihan Wang Linfang Qian +3 位作者 Liu Yang Taisu Liu Weiwei Chen Haolin Zhang 《Defence Technology(防务技术)》 2025年第6期115-130,共16页
The swinging-loading process is essential for automatic artillery loading systems.This study focuses on the problems of reliability analysis that affect swinging-loading positioning accuracy.A dynamic model for a mult... The swinging-loading process is essential for automatic artillery loading systems.This study focuses on the problems of reliability analysis that affect swinging-loading positioning accuracy.A dynamic model for a multi degree-of-freedom swinging-loading-integrated rigid-flexible coupling system is established.This model is based on the identification of key parameters and platform experiments.Based on the spatial geometric relationship between the breech and loader during modular charge transfer and the possible maximum interference depth of the modular charge,a new failure criterion for estimating the reliability of swinging-loading positioning accuracy is proposed.Considering the uncertainties in the operation of the pendulum loader,the direct probability integration method is introduced to analyze the reliability of the swinging-loading positioning accuracy under three different charge numbers.The results indicate that under two and four charges,the swinging-loading process shows outstanding reliability.However,an unstable stage appears when the swinging motion occurred under six charges,with a maximum positioning failure probability of 0.0712.A comparison between the results obtained under the conventional and proposed criteria further reveals the effectiveness and necessity of the proposed criterion. 展开更多
关键词 Artillery loading system Pendulum loader Dynamic model Failure criterion reliability analysis
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SL-COA:Hybrid Efficient and Enhanced Coati Optimization Algorithm for Structural Reliability Analysis
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作者 Yunhan Ling Huajun Peng +4 位作者 Yiqing Shi Chao Xu Jingzhen Yan Jingjing Wang Hui Ma 《Computer Modeling in Engineering & Sciences》 2025年第4期767-808,共42页
Thetraditional first-order reliability method(FORM)often encounters challengeswith non-convergence of results or excessive calculation when analyzing complex engineering problems.To improve the global convergence spee... Thetraditional first-order reliability method(FORM)often encounters challengeswith non-convergence of results or excessive calculation when analyzing complex engineering problems.To improve the global convergence speed of structural reliability analysis,an improved coati optimization algorithm(COA)is proposed in this paper.In this study,the social learning strategy is used to improve the coati optimization algorithm(SL-COA),which improves the convergence speed and robustness of the newheuristic optimization algorithm.Then,the SL-COAis comparedwith the latest heuristic optimization algorithms such as the original COA,whale optimization algorithm(WOA),and osprey optimization algorithm(OOA)in the CEC2005 and CEC2017 test function sets and two engineering optimization design examples.The optimization results show that the proposed SL-COA algorithm has a high competitiveness.Secondly,this study introduces the SL-COA algorithm into the MPP(Most Probable Point)search process based on FORM and constructs a new reliability analysis method.Finally,the proposed reliability analysis method is verified by four mathematical examples and two engineering examples.The results show that the proposed SL-COA-assisted FORM exhibits fast convergence and avoids premature convergence to local optima as demonstrated by its successful application to problems such as composite cylinder design and support bracket analysis. 展开更多
关键词 Hybrid reliability analysis single-loop interactive hybrid analysis most probability point metaheuristic algorithms coati optimization algorithm
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Structural Reliability Analysis Method Based on Kriging and Spherical Cap Area Integral
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作者 ZHANG Jixiang CHEN Zhenzhong +3 位作者 CHEN Ge LI Xiaoke ZHAO Pengcheng PAN Qianghua 《Journal of Donghua University(English Edition)》 2025年第4期409-416,共8页
In the structural reliability analysis,the first-order reliability method(FORM)often yields significant errors when addressing nonlinear problems.Although the second-order reliability method(SORM)can provide higher ac... In the structural reliability analysis,the first-order reliability method(FORM)often yields significant errors when addressing nonlinear problems.Although the second-order reliability method(SORM)can provide higher accuracy,the additional computation of the Hessian matrix leads to lower computational efficiency.Additionally,when the dimensionality of the random variables is high,the approximation formula of SORM can result in larger errors.To address these issues,a structural reliability analysis method based on Kriging and spherical cap area integral is proposed.Firstly,this method integrates FORM with the quasi-Newton algorithm Broyden-Fletcher-Goldfarb-Shanno(BFGS),trains the Kriging model by using sample points from the algorithm’s iteration process,and combines the Kriging model with gradient information to approximate the Hessian matrix.Then,the failure surface is approximated as a rotating paraboloid,utilizing the spherical cap to replace the complex surface.For the n-dimensional case,the hyperspherical cap area expression is combined with the integral method to calculate the failure probability.Finally,the method is validated through three examples,demonstrating improved computational accuracy and efficiency compared to traditional methods. 展开更多
关键词 structural reliability analysis quasi-Newton algorithm Kriging model spherical cap area integral
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WPPSI-III in Sudan:Validity,reliability,and confirmatory factor analysis in khartoum kindergarten and primary schools
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作者 Rwaa Omer Ali Ahmed Salaheldin Farah Attallah Bakhiet +2 位作者 Ayman Mohamed Taha Abdelaziz Ahmed FadlAlMawla AbdulRadi Ismael Salamah Albursan 《Journal of Psychology in Africa》 2025年第4期431-439,共9页
The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum S... The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum State,Sudan.It also aims to examine whether test’s factor structure in this sample replicated that of the original WPPSI-III.The study sample consisted of 384 kindergarten and primary school children in Khartoum State(females=50%mean age=4.14,SD=1.37),selected using stratified random sampling across its seven localities:Khartoum,Jebel Awliya,Khartoum Bahri,East Nile,Omdurman,Ombada,Karari.For concurrent validation,the children additionally completed the Goodenough Draw-a-Man Test,and the Colored Progressive Matrices.WPPSI-III scores demonstrated high internal consistency across the subtest items.Confirmatory factor analysis indicators for total,verbal,and performance intelligence were all excellent.The scale also showed weak to strong score stability ranging from 0.25(weak)to 0.88(strong)based on the Spearman-Brown equation,0.25 to 0.75 based on the Guttman split-half method.The Cronbach’s alpha coefficient scores ranged from 0.54 to 0.93.The WPPSI-III and Goodenough Draw-a-Man Test scores concurrent validity scores were poor(0.05)to modest(0.31),and while those with the Colored Progressive Matrices test were poor(r=0.04–0.18).Thesefindings provide evidence to suggest that the WPPSI-III is appropriate for research use with kindergarten and lower primary school students in Khartoum State,Sudan. 展开更多
关键词 intelligence tests VALIDATION reliability primary schools kindergartens confirmatory factor analysis cognitive abilities WPPSI-III SUDAN
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Evaluation of Deterioration Law and Reliability of Concrete after Durability Improvement Based on Wiener Theory
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作者 SHI Hongzhuang SU Fuyun +3 位作者 QIAO Hongxia ZHANG Lei FU Yong YANG Xiaosen 《Journal of Wuhan University of Technology(Materials Science)》 2026年第1期147-161,共15页
To study the durability of concrete in harsh environments in Northwest China,concrete was prepared with various durability-improving materials such as concrete anti-erosion inhibitor(SBT-TIA),acrylate polymer(AP),supe... To study the durability of concrete in harsh environments in Northwest China,concrete was prepared with various durability-improving materials such as concrete anti-erosion inhibitor(SBT-TIA),acrylate polymer(AP),super absorbent resin(SAP).The erosion mode and internal deterioration mechanism under salt freeze-thaw cycle and dry-wet cycle were explored.The results show that the addition of enhancing materials can effectively improve the resistance of concrete to salt freezing and sulfate erosion:the relevant indexes of concrete added with X-AP and T-AP are improved after salt freeze-thaw cycles;concrete added with SBTTIA shows optimal sulfate corrosion resistance;and concrete added with AP displays the best resistance to salt freezing.Microanalysis shows that the increase in the number of cycles decreases the generation of internal hydration products and defects in concrete mixed with enhancing materials and improves the related indexes.Based on the Wiener model analysis,the reliability of concrete with different lithologies and enhancing materials is improved,which may provide a reference for the application of manufactured sand concrete and enhancing materials in Northwest China,especially for the study of the improvement effects and mechanism of enhancing materials on the performance of concrete. 展开更多
关键词 manufactured sand concrete durability enhancement enhancing materials reliability analysis
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Development and Reliability and Validity Analysis of an Assessment Tool for Postoperative Wound Healing in Adult Patients with Benign Anal Canal and Rectal Diseases
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作者 Xiaomei Chang Shenglin Hu +5 位作者 Min Zhu Min Zou Min Li Guorong Li Zhi Feng Hongbo Li 《Journal of Clinical and Nursing Research》 2025年第11期293-300,共8页
Objective:This study aims to develop an assessment tool for postoperative wound healing in adult patients with benign anal canal and rectal diseases and to validate its reliability and validity.Methods:Based on Levine... Objective:This study aims to develop an assessment tool for postoperative wound healing in adult patients with benign anal canal and rectal diseases and to validate its reliability and validity.Methods:Based on Levine’s Conservation Model as the theoretical framework,an item pool was formed through literature review,and the initial draft of the scale was refined through two rounds of Delphi expert consultation.A total of 200 postoperative patients were selected for item analysis,internal consistency testing,content validity,and structural validity analysis.Results:The final tool comprises four dimensions:energy conservation,structural integrity,personal integrity,and social integrity,with a total of 24 items.It demonstrates good content validity(I-CVI 0.82-1.00,S-CVI/Ave 0.95,S-CVI/UA 0.87)and excellent internal consistency(Cronbach’sαfor the overall scale was 0.934).Exploratory factor analysis revealed a KMO value of 0.931,Bartlett’s test of sphericityχ^(2)=4147.853(p<0.001),and four common factors were extracted,accounting for a cumulative variance contribution rate of 64.345%,indicating ideal structural validity.Conclusion:The results indicate that the assessment tool has good reliability and validity and can systematically evaluate postoperative wound healing,providing a scientific basis for clinical individualized nursing interventions. 展开更多
关键词 Anal canal RECTUM Benign diseases Wound healing Assessment tool reliability Validity
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Belief reliability modeling and analysis for TPS considering physical principles,degradation mechanism and epistemic uncertainties
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作者 Dayu CHEN Yao LI +4 位作者 Yiyang SHANGGUAN Zhiqiang LI Zhenqiang WU Xiaoyang LI Rui KANG 《Chinese Journal of Aeronautics》 2025年第5期262-274,共13页
Thermal Protection System(TPS)with thick tiles,low thermal conductivity,and a short re-entry stage stands as a critical element within reusable aircraft,whose reliability is related to the function and changes with th... Thermal Protection System(TPS)with thick tiles,low thermal conductivity,and a short re-entry stage stands as a critical element within reusable aircraft,whose reliability is related to the function and changes with their physical properties,external conditions,and degradation.Meanwhile,due to the limitation of testing resources,epistemic uncertainties stemming from the small samples are present in TPS reliability modeling.However,current TPS reliability modeling methods face challenges in characterizing the relationships among reliability and physical properties,external conditions,degradation,and epistemic uncertainties.Therefore,under the framework of belief reliability theory,a TPS reliability model is constructed,which takes into account the physical principle,external conditions,performance degradation,and epistemic uncertainties.A reliability simulation algorithm is proposed to calculate TPS reliability.Through a case study and comparison analysis,the proposed method is validated as more effective than the existing method.Additionally,reliability sensitivity analysis is conducted to identify the sensitive factors of reliability under the condition of small samples,through which suggestions are provided for TPS functional design and improvement. 展开更多
关键词 Thermal protection system Physical principle Epistemic uncertainty Performance degradation Belief reliability modeling
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Calibration and Reliability Analysis of Eccentric Compressive Concrete Column with High Strength Rebars
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作者 Baojun Qin Hong Jiang +1 位作者 Wei Zhang Xiang Liu 《Structural Durability & Health Monitoring》 2025年第5期1203-1220,共18页
The utilization of high-strength steel bars(HSSB)within concrete structures demonstrates significant advantages in material conservation and mechanical performance enhancement.Nevertheless,existing design codes exhibi... The utilization of high-strength steel bars(HSSB)within concrete structures demonstrates significant advantages in material conservation and mechanical performance enhancement.Nevertheless,existing design codes exhibit limitations in addressing the distinct statistical characteristics of HSSB,particularly regarding strength design parameters.For instance,GB50010-2010 fails to specify design strength values for reinforcement exceeding 600 MPa,creating technical barriers for advancing HSSB implementation.This study systematically investigates the reliability of eccentric compression concrete columns reinforced with 600 MPa-grade HSSB through high-order moment method analysis.Material partial factors were calibrated against target reliability indices prescribed by GB50068-2018,incorporating critical variables including live-to-dead load ratios,design methodologies,and service conditions.The findings show that the value of k significantly affects the calibration of material partial factors,impacting the reliability of bearing capacity.Considering various k values and target reliability indices,it is recommended that the material partialfactorbe setat1.15,implyingthatthedesignstrengthfor600MPahigh-strengthsteelbars shouldbe considered as 522 MPa.For safety levels I and II,load adjustment factors of 1.1 and 0.9,respectively,may be applied. 展开更多
关键词 reliability high-strength steel rebar concrete column material partial factor high-order moment method failure probability
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Development of a framework for safety and resilience in overhead power cables:Use of a fuzzy inference system for risk and reliability analysis
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作者 A.M.Sakura R.H.Attanayake R.M.Chandima Ratnayake T.Markeset 《Journal of Safety Science and Resilience》 2025年第4期586-600,共15页
Ensuring the safety,resilience,and reliability of overhead low-voltage(LV)and medium-voltage(MV)power cables in aging infrastructure is vital for maintaining essential services and mitigating risks in electrical power... Ensuring the safety,resilience,and reliability of overhead low-voltage(LV)and medium-voltage(MV)power cables in aging infrastructure is vital for maintaining essential services and mitigating risks in electrical power distribution systems.This study introduces a novel framework that integrates fault tree analysis(FTA)/failure mode and effect analysis(FMEA)and a fuzzy inference system(FIS)to systematically address performance variability and enhance the operational life of these critical assets while ensuring safety and resilience.This structured framework employs risk-informed decision-making as well as reliability-based safety and resilience assurance,incorporating international standards and best practices.Under this methodology,the FIS models uncertainties in asset performance,using expert-defined rules and membership functions to categorize risk levels and assess failure severity.A case study is performed on overhead MV power cables,specifically the"Racoon"allaluminum alloy conductor(AAAC),demonstrating its practical implementation.The results reveal that for typical environmental conditions and design parameters,the yearly reliability of the conductor is nearly 1,indicating compliance with IEC standards.Furthermore,a risk matrix is developed using current carrying capacity(CCC),a failure mode obtained from the FTA as the probability of occurrence,and power shutdown duration(PSD)as the severity indicator.The risk matrix estimates the potential risk(PR)level based on CCC and PSD inputs.For example,for CCC=260 A and PSD=50 min,the resulting PR is 12.9,indicating a moderate risk exists.These risk levels guide appropriate resilience actions,ensuring proactive power cable management by identifying critical risks,prioritizing mitigation measures,and ensuring adaptability and compliance.This approach not only addresses the challenges of aging infrastructure but also contributes to long-term system integrity and operational reliability. 展开更多
关键词 Framework Fuzzy inference system(FIS) International standards Power cables reliability RESILIENCE RISK SAFETY
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 被引量:2
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作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
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Statistics and Development Analysis of Urban Rail Transit in China by the End of 2025
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作者 WANG Fuwen LIANG Shuaiwen FENG Aijun 《隧道建设(中英文)》 北大核心 2026年第2期437-444,I0005-I0012,共16页
First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a to... First,statistics on the operational lines and mileage of urban rail transit in China are conducted.The results show that,as of Dec.31,2025,there were 60 cities with urban rail transit in operation nationwide,with a total operational mileage of approximately 12837.8 km(excluding the electronic guideway rubber-tired system,there were 57 cities,with a total operational mileage of 12651.6 km).The metro system dominates,while low-capacity systems exhibit a multi-modal development pattern.Subsequently,the characteristics of China′s urban rail transit industry development are analyzed,indicating that:(1)It should closely align with the theme of urban intensive development,promote quality improvement and efficiency enhancement of existing lines,and focus on the supporting role of initial passenger flow for new line construction,multi-network integration,and economic and financial sustainability.(2)Significant innovative achievements have been made in safety resilience,green and low-carbon development,intelligent construction,and digital transformation.Finally,development recommendations for the"15th Five-Year Plan"period are proposed:promoting cost reduction and efficiency improvement in the rail transit industry,enhancing the operational efficiency of existing networks,continuously exploring railway services for urban commuting,strengthening external exchanges,and driving the"going global"strategy of the urban rail transit industry. 展开更多
关键词 rail transit operational lines data statistics development analysis
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Crystal structure,thermal analysis,and luminescence properties of six heterocyclic lanthanide complexes
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作者 SONG Zihe ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2026年第1期181-192,共12页
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'... Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6. 展开更多
关键词 lanthanide complexes fluorescence property crystal structure thermal analysis
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Demonstration of InSnO thin-film transistors with superior uniformity and reliability utilizing SiO_(2)passivation
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作者 Tingrui Huang Jie Cao +7 位作者 Zuoxu Yu Yuzhen Zhang Wenting Xu Xifeng Li Cong Peng Weifeng Sun Guangan Yang Wangran Wu 《Journal of Semiconductors》 2026年第2期15-21,共7页
In this work,we demonstrated the InSnO(ITO)TFTs passivated with SiO_(2)via the PECVD process compatible with large-area production for the first time.The passivated ITO TFTs with various channel thicknesses(t_(ch)=4,5... In this work,we demonstrated the InSnO(ITO)TFTs passivated with SiO_(2)via the PECVD process compatible with large-area production for the first time.The passivated ITO TFTs with various channel thicknesses(t_(ch)=4,5,6 nm)exhibit excellent electrical performance and superior uniformity.The reliability properties of ITO TFTs were evaluated in detail under positive bias stress(PBS)conditions before and after passivation.Compared to the devices without passivation,the passivated devices have only 50%threshold voltage degradation(ΔV_(th))and 50%newly generated traps due to excellent isolation of the ambient atmosphere.The negligible performance degradation of ITO TFTs with passivation during negative bias stress(NBS)and negative bias temperature stress(NBTS)verifies the outstanding immunity to the water vapor of the SiO_(2)passivation layer.Overall,the ITO TFT with the t_(ch)of 6 nm and with SiO_(2)passivation exhibits the best performance in terms of electrical properties,uniformity,and reliability,which is promising in large-area production. 展开更多
关键词 thin film transistor reliability INSNO SiO_(2)
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Cavity ring-down spectroscopy CO gas sensor integrating principal component analysis with savitzky-golay filtering
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作者 GUO Zi-long SHI Cheng-rui +4 位作者 DONG Yuan-yuan ZHANG Lei SUN Xiao-yuan SUN Jing-jing ZHOU Sheng 《中国光学(中英文)》 北大核心 2026年第1期179-189,共11页
The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recogni... The Savitzky-Golay(SG)filter,which employs polynomial least-squares approximations to smooth data and estimate derivatives,is widely used for processing noisy data.However,noise suppression by the SG filter is recognized to be limited at data boundaries and high frequencies,which can significantly reduce the signal-to-noise ratio(SNR).To solve this problem,a novel method synergistically integrating Principal Component Analysis(PCA)with SG filtering is proposed in this paper.This approach avoids the is-sue of excessive smoothing associated with larger window sizes.The proposed PCA-SG filtering algorithm was applied to a CO gas sensing system based on Cavity Ring-Down Spectroscopy(CRDS).The perform-ance of the PCA-SG filtering algorithm is demonstrated through comparison with Moving Average Filtering(MAF),Wavelet Transformation(WT),Kalman Filtering(KF),and the SG filter.The results demonstrate that the proposed algorithm exhibits superior noise reduction capabilities compared to the other algorithms evaluated.The SNR of the ring-down signal was improved from 11.8612 dB to 29.0913 dB,and the stand-ard deviation of the extracted ring-down time constant was reduced from 0.037μs to 0.018μs.These results confirm that the proposed PCA-SG filtering algorithm effectively improves the smoothness of the ring-down curve data,demonstrating its feasibility. 展开更多
关键词 cavity ring-down spectroscopy CO gas sensor principal component analysis Savitzky-Golay filter
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Artificial intelligence-assisted non-metallic inclusion particle analysis in advanced steels using machine learning:A review
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作者 Gonghao Lian Xiaoming Liu +3 位作者 Qiang Wang Chunguang Shen Yi Wang Wangzhong Mu 《International Journal of Minerals,Metallurgy and Materials》 2026年第2期401-416,共16页
The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial in... The detection and characterization of non-metallic inclusions are essential for clean steel production.Recently,imaging analysis combined with high-dimensional data processing of metallic materials using artificial intelligence(AI)-based machine learning(ML)has developed rapidly.This technique has achieved impressive results in the field of inclusion classification in process metallurgy.The present study surveys the ML modeling of inclusion prediction in advanced steels,including the detection,classification,and feature prediction of inclusions in different steel grades.Studies on clean steel with different features based on data and image analysis via ML are summarized.Regarding the data analysis,the inclusion prediction methodology based on ML establishes a connection between the experimental parameters and inclusion characteristics and analyzes the importance of the experimental parameters.Regarding the image analysis,the focus is placed on the classification of different types of inclusions via deep learning,in comparison with data analysis.Finally,further development of inclusion analyses using ML-based methods is recommended.This work paves the way for the application of AIbased methodologies for ultraclean-steel studies from a sustainable metallurgy perspective. 展开更多
关键词 machine learning inclusion classification image analysis data analysis clean steel
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