Ecological shelter zones reconstruction is an ecosystem restoration and conservation project aimed to the ecological safety of nations, regions and basins. Reconstruction of ecological shelter zones of the upper reach...Ecological shelter zones reconstruction is an ecosystem restoration and conservation project aimed to the ecological safety of nations, regions and basins. Reconstruction of ecological shelter zones of the upper reaches of the Yangtze River became one of the most important tasks of Western Development strategy. This article, taking Zhaotong as an example, studies the functional regionalization of ecological shelter zones. The study supplies a case for functional regionalization of small and medium regions whose main tasks are environment reservation. With the guidance of theories of functional regionalization, and based on the analysis of Zhaotong＇s natural, ecological and socioeconomic factors, the paper suggests five principles for factors selection. These principles include： （1） reversing order evaluation; （2） selecting main factors; （3） keeping the integrality of administrative regions of towns; and （4） making the products acceptable by local government. To analyze spatial status of selected factors, LUCC data in 2002, 1：50,000 relief maps and town-unit socioeconomic statistical data in 2004 are used. RS and GIS tools are also applied to melt traditional and modern geographical methods. This would be useful to functional regionalization research in mountainous areas. As a conclusion, the leading functional regions of ecological conservation or economic development are suggested, respectively. Zhaotong city is divided into two-level functional regions. The first-level includes three leading functional regions and they will lead developing direction of sub-regions. The second-level includes eight sub-regions, which are policy implemented regions, and will supply guidance to Zhaotong＇s ecological shelter zones reconstruction.展开更多
AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patient...AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM.展开更多
The left ventricular regional systolic functions in patients with hypertrophic cardiomyopathy （HCM） were assessed by using quantitative tissue velocity imaging （QTVI）. Left ventricular （LV） regional myocardial v...The left ventricular regional systolic functions in patients with hypertrophic cardiomyopathy （HCM） were assessed by using quantitative tissue velocity imaging （QTVI）. Left ventricular （LV） regional myocardial velocity along long- and short-axis in 31 HCM patients and 20 healthy subjects were analyzed by QTVI, and the regional myocardial systolic peak velocities （MVS） were measured. Mean MVS at each level including mitral annular, basal, middle and apical segments were calculated. The ratio of MVS along long-axis to that along short-axis （Ri） at basal and middle segments of the LV posterior wall and ventricular septum were calculated. The results showed that mean MVS was slower at each level including mitral annular, basal, middle and apical segments in the HCM patients than that in the healthy subjects （P〈0.01）. There were no significant differences in mean MVS between obstructive and non-obstructive groups in HCM patients. MVS of all regional myocardial segments along long-axis in the HCM patients were significantly slower than that in the healthy subjects （P〈0.05）, but there was no significant difference in MVS of all regional myocardial segments along long-axis between hypertrophied and non-hypertrophied group in the HCM patients. Ri was significantly lower in the HCM patients than that in the healthy subjects. The LV regional myocardial contractility along long-axis was impaired not only in the hypertrophied wall but also in the non-hypertrophied one in patients with HCM, suggesting that QTVI can assess accurately LV regional systolic function in patient with HCM and provides a novel means for an early diagnosis before and independent of hypertrophy.展开更多
Reasonable development and utilization of spatial resources in the coastal zone not only affects the development quality of the marine economy but also impacts the utilization efficiency of spatial resources,playing a...Reasonable development and utilization of spatial resources in the coastal zone not only affects the development quality of the marine economy but also impacts the utilization efficiency of spatial resources,playing an important role in regional sustainable development.Depending on the natural,economic,and societal characteristics of a region,research topics such as using relevant methods to divide the coastline,proper spatial development of the coast,protecting coastal zones,and achieving higher spatial resource distribution efficiency have recently become hot topics in geographic research.Most of the scholars construct the evaluation index system from the perspective of economic and ecological factors and undertake some exploration of the division methods.However,the selection of indicators for a coastal zone needs a different and more scientific approach.There is a need for emphasizing the overall strategy of land-ocean integration in developing spatial resources in a coastal zone.Taking the coastal zone in Ningbo as an example,this paper develops a new evaluation framework and spatial function regionalization method that is used to divide the coastline and coastal zone.Based on the perspective of overall strategy for the land and ocean,we evaluate the suitability of coastline development.We then propose the spatial function regionalization of the coastal zone.Finally,based on the status quo of spatial development in Ningbo,we divide the coastal zone into ecological space,production space and living space,and propose adjustment directions and control requirements for the different types of spatial layouts.展开更多
The value of tissue strain imaging （SI） in regional myocardial systolic and diastolic func tion assessment was studied. In 18 patients with nonobstructive hypertrophic cardiomyopathy （HCM） and 20 age-matched healt...The value of tissue strain imaging （SI） in regional myocardial systolic and diastolic func tion assessment was studied. In 18 patients with nonobstructive hypertrophic cardiomyopathy （HCM） and 20 age-matched healthy subjects, regional myocardial longitudinal peak systolic strain in eject time （represented by εet） was measured at basal, mid and apical segments of septal, lateral and posterior walls of the left ventricle （LV） and compared between groups, εet had no significant difference between segments in control group （P〉0.05）, which displayed a decreasing trend from basal segments to apical ones. εet in the HCM group was significantly decreased （P（0. 05） as compared with that in the healthy group. In the HCM group, εet in the midseptum was significantly less than at the basal and apical septum, and was also less than at the rest LV walls in the same group （P〉0.01）. The systolic reversed εet was noticed in 35% of the hypertrophic segments in HCM group. Significantly negative correlation existed between the absolute value of εet and wall thickness in the midseptum （r= -0.83）. The post-systolic strain（PSS） segment number the and amplitudes in healthy group were significantly less than those in HCM group （P〈0.05）. Both regional myocardial systolic and diastolic functions were impaired in hypertrophic or non-hypertrophic segments in patients with the HCM, especially in hypertrophic segments. Strain imaging technique is a sensitive and accura tool in myocardial dysfunction assessment.展开更多
The middle and lower reaches of the Tarim River are currently one of the main regions of ecological restoration in the arid areas of western China.Using the principles and method of landscape ecology,this study has ch...The middle and lower reaches of the Tarim River are currently one of the main regions of ecological restoration in the arid areas of western China.Using the principles and method of landscape ecology,this study has chosen the fluvial corridor landscape in the middle and lower reaches of the Tarim River,and discusses the region’s ecologically functional regionalization system and issues related to its practical classification.On this basis the corresponding regionalizing principles and standards were developed which were used to qualitatively divide the three main landscapes as the ecologically functional areas in the drainage basin.The paper has also analyzed the characteristic of the study areas,and has put forward the measures for its ecological restoration.展开更多
The process of urbanization is formed by regular movements of human beings. It yields different functional zones in a city, such as residential zone and commercial zone. Consequently, there exists a close connection b...The process of urbanization is formed by regular movements of human beings. It yields different functional zones in a city, such as residential zone and commercial zone. Consequently, there exists a close connection between the human mobility pattern and the city＇s zones. However, it is not easy to collect large-scale society-wide data that can precisely capture the underlying relations between the individual＇s movement and the regional functions. Hence, our knowledge for understanding the basic patterns of human mobility is still limited. In order to discover the functions of different regions in a city, we propose an affinity based method in this paper. The affinity is a recently introduced metric for measuring the correlation of two connecting node in a complex network. The proposed model groups different functional zones by measuring user＇s arrival/departure distribution via relative entropy. In addition to this, we also identify the intensity of each functional zone by taking kernel density estimation （KDE） method. In the end, some experiments are conducted to evaluate our method with a large-scale real-life dataset, which consists of 3 million cellphone users＇ records from a period of one month. Our findings on the interaction between the mobility pattern and the regional functions can capture the city dynamics efficiently and provide a valuable reference for urban planners.展开更多
The object of this article is to introduce new classes of meromorphic functions associated with conic regions. Several properties like the coefficient bounds, growth and distortion theorems, radii of starlikeness and ...The object of this article is to introduce new classes of meromorphic functions associated with conic regions. Several properties like the coefficient bounds, growth and distortion theorems, radii of starlikeness and convexity, partial sums, are investigated. Some consequences of the main results for the well-known classes of meromorphic functions are also pointed out.展开更多
As the Rural Revitalization Strategy is gradually implemented, China’s rural areas are set to have more diverse function requirements. This paper selects the Changsha-Zhuzhou-Xiangtan region(Chang-Zhu-Tan) consisting...As the Rural Revitalization Strategy is gradually implemented, China’s rural areas are set to have more diverse function requirements. This paper selects the Changsha-Zhuzhou-Xiangtan region(Chang-Zhu-Tan) consisting of 23 county-level units) as a case study and looks at its economic development, agricultural product supply, social security and ecological service functions during 1996–2016. It then constructs an index system to evaluate the temporal evolution of the region’s rural functions. SPSS 19.0 and DPS 7.05 software, as well as Pearson’s correlation coefficient analysis, system clustering, optimal segmentation of ordered samples and other methods, are used to study the evolution traits, regional differentiation characteristics and driving forces of rural functions in the region. The results show, first of all, that the overall evolution trend is increasing in functions with periodic characteristics, the key nodes being 2000 and 2008. Second, there is clear geographical differentiation in the evolution of rural functions. The economic development function shows rapid growth in the urban agglomeration’s center and relatively weak growth at the periphery;the agricultural product supply function and ecological service function are concentrated in county-level units with abundant cultivated and forest land;and the social security function displays similar geographical differentiation to the economic development function. Overall, there is an obvious discrepancy in the degree of development of rural functions among county-level units of the Changsha-Zhuzhou-Xiangtan urban agglomeration;the rural functions of the agglomeration and peripheral county-level units have different development traits;and county-level units display functional differentiation. Third, rural functions have evolved as a result of interactions between various factors, such as natural resources, socio-economic conditions and local transport conditions. The new driving forces caused by urbanization are ultimately leading the evolution of rural functions toward multi-functional comprehensive development.展开更多
Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting...Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson＇s disease patients with right resting tremor, and from eight age-matched normal controls. Regional homogeneity was compared between Parkinson＇s disease patients and controls. The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus. Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson＇s disease patients compared with healthy controls.展开更多
Population density functions have long been used to describe the spatial structure of regional population distributions.Several studies have been conducted to examine the population distribution in Shandong Province,C...Population density functions have long been used to describe the spatial structure of regional population distributions.Several studies have been conducted to examine the population distribution in Shandong Province,China,but few have applied regional density functions to the analysis.Therefore,based on the 2000,2010,and 2020 population censuses,this study used monocentric and polycentric regional density functions to study the characteristics of population agglomeration and diffusion in Shandong.This is followed by an in-depth discussion based on population growth rate data and hot-and cold-spot analyses.The results showed that the Shandong Province population was spatially unevenly distributed.Population growth rates were higher in urban centers and counties,with more significant changes in population size in the eastern coastal areas than in the inland areas.As verified in this study,the logarithmic form of the single-center regional density function R2 was greater than 0.8,which was in line with the population spatial structure of Shandong Province.During the study period,the estimated population density of the regional center and the absolute value of the regional population density gradient both increased,indicating a clear and increasing trend of centripetal agglomeration of regional centers over the study period.Overall,the R2 value of the multicenter region density function was higher than that of the single-center region density function.The polycentric regional density function showed that the population density gradient of some centers had a downward trend,which reflected the spatial development trend of outward diffusion in these centers.Meanwhile,the variation in the estimated population density and the population density gradient exhibited differences in the central population distribution patterns at different levels.展开更多
As a result of rapid urbanization in China, urban sprawl has increased rapidly, and land-use regulation and smart urban growth are equally important. Spatial function regionalization can provide the scientific groundw...As a result of rapid urbanization in China, urban sprawl has increased rapidly, and land-use regulation and smart urban growth are equally important. Spatial function regionalization can provide the scientific groundwork for the regulation of land use and protection. This paper probes the system of evaluation indices and applies the methods of spatial analysis and classification clustering to the calculation of the ecologically significant value and economically significant value in each evaluation unit. After use of a classification matrix integrated by the two significant values, city space can be divided into four functional types, namely, feasible development area, moderate development area, moderate conservation area and prohibited exploiting area, and these are the basis for spatial development and control.展开更多
BACKGROUND： An increasing number of studies have shown the effects of aging in basic cognitive processing and higher cognitive functions using functional magnetic resonance imaging （fMRI）. However, little is known ...BACKGROUND： An increasing number of studies have shown the effects of aging in basic cognitive processing and higher cognitive functions using functional magnetic resonance imaging （fMRI）. However, little is known about the aging effects in diverse cognitive abilities, such as spatial learning and reasoning. OBJECTIVE： To investigate the effect of aging on spatial cognitive performance and regional brain activation based on fMRI. DESIGN, TIME, AND SETTING： A block design for fMRI observation. This study was performed at the fMRI Laboratory, Brain Science Research Center, Korea Advanced Institute of Science and Technology from March 2006 to May 2009. PARTICIPANTS： Eight right-handed, male, college students in their 20s （mean age 21.5 years） and six right-handed, male, adults in their 40s （mean age 45.7 years）, who graduated from college, participated in the study. All subjects were healthy and had no prior history of psychiatric or neurological disorders. METHODS： A spatial task was presented while brain images were acquired using a 3T fMRI system （ISOL Technology, Korea）. The spatial tasks involved selecting a shape that corresponded to a given figure using four examples, as well as selecting a development figure of a diagram. MAIN OUTCOME MEASURES： The accuracy rate （number of correct answers/total number of items x 100%） of spatial tasks was calculated. Using the subtraction procedure, the activated areas in the brain during spatial tasks were color-coded by T-score. The double subtraction method was used to analyze the effect of aging between the two age groups （20s versus 40s）. RESULTS： The cerebellum, occipital lobe, parietal lobe, and frontal lobe were similarly activated in the two age groups. Increased brain activations, however, were observed in bilateral parietal and superior frontal lobes of the younger group. More activation was observed in bilateral middle frontal and right inferior frontal lobes in the older group. Compared with the older group, the younger men exhibited greater spatial performance （P = 0.012）. CONCLUSION： Reduced cognitive function correlated with decreased activation areas in the parietal lobe and altered activation in the frontal lobe.展开更多
This article introduces a novel low rank approximation (LRA)-based model to detect the functional regions with the data from about 15 million social media check-in records during a year-long period in Shanghai, China....This article introduces a novel low rank approximation (LRA)-based model to detect the functional regions with the data from about 15 million social media check-in records during a year-long period in Shanghai, China. We identified a series of latent structures, named latent spatio-temporal activity structures. While interpreting these structures, we can obtain a series of underlying associations between the spatial and temporal activity patterns. Moreover, we can not only reproduce the observed data with a lower dimensional representative, but also project spatio-temporal activity patterns in the same coordinate system. With the K-means clustering algorithm, five significant types of clusters that are directly annotated with a combination of temporal activities can be obtained, providing a clear picture of the correlation between the groups of regions and different activities at different times during a day. Besides the commercial and transportation dominant areas, we also detected two kinds of residential areas, the developed residential areas and the developing residential areas.We further interpret the spatial distribution of these clusters using urban form analytics. The results are highly consistent with the government planning in the same periods, indicating that our model is applicable to infer the functional regions from social media check-in data and can benefit a wide range of fields, such as urban planning, public services, and location-based recommender systems.展开更多
Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measu...Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging （fMRI）, between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent （BOLD） fMRI and analyzed using the measure of regional homogeneity （ReHo） during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.展开更多
The application of Tikhonov regularization method dealing with the ill-conditioned problems in the regional gravity field modeling by Poisson wavelets is studied. In particular, the choices of the regularization matri...The application of Tikhonov regularization method dealing with the ill-conditioned problems in the regional gravity field modeling by Poisson wavelets is studied. In particular, the choices of the regularization matrices as well as the approaches for estimating the regularization parameters are investigated in details. The numerical results show that the regularized solutions derived from the first-order regularization are better than the ones obtained from zero-order regularization. For cross validation, the optimal regularization parameters are estimated from L-curve, variance component estimation（VCE） and minimum standard deviation（MSTD） approach, respectively, and the results show that the derived regularization parameters from different methods are consistent with each other. Together with the firstorder Tikhonov regularization and VCE method, the optimal network of Poisson wavelets is derived, based on which the local gravimetric geoid is computed. The accuracy of the corresponding gravimetric geoid reaches 1.1 cm in Netherlands, which validates the reliability of using Tikhonov regularization method in tackling the ill-conditioned problem for regional gravity field modeling.展开更多
According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action ofbiaxial load...According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action ofbiaxial load after the comparison of the stress distribution characteristics of the ballast track subgrade bed structures for high-speed railway under the action of uniaxial load and biaxial load. The loading threshold value （high-cycle long-term dynamic strength） under the circum- stance where the cumulative deformation of subgrade structure gradually develops and finally reaches the convergent state, and its relationship with the foundation coefficient K30 were deduced, based on the characteristics of cumulative defor- mation evolution obtained from the unit structure filling model test under the action of cyclic loading. In view of structure stability and frost resistance requirements of the railway subgrade in cold regions, technical conditions to maintain good service performance of subgrade structure of high-speed railway ballasted track are discussed and analyzed. Study results show that the additive effect manifests itself obviously for railway train bogies under the action of biaxial load than uni- axial load, which has a significant dynamic effect on the subgrade bed bottom and a slight effect on the surface layer. Thus, the adoption of a biaxial load model in the design of a high-speed railway subgrade accurately reflects the vehicle load. Pursuant to the structure design principle, the design method of the subgrade structure of high-speed railway ballasted track is proposed to meet the technical requirements such as structural strength, bearing stiffness and high-cyclic and long-term stability. Technical indicators are obtained for the variation of thickness of the surface layer of reinforced sub- grade bed in the double-layer subgrade mode along with the change of K30 at the subgrade bed bottom. The double-layer structure mode of ＂closure on the upper layer and drainage on the lower layer＂ was proposed in order to meet the water- proofing and drainage requirements of the upper layer of the subgrade bed in cold regions. A dense-framework graded gravel filler with weak water permeability at a coefficient of 10 4 cm/s is used on the upper layer and the void-framework graded gravel filler at the water permeability coefficient of 10 2 cm/s is adopted on the lower layer.展开更多
基金National Natural＇Science Foundation of China, No.40401016
文摘Ecological shelter zones reconstruction is an ecosystem restoration and conservation project aimed to the ecological safety of nations, regions and basins. Reconstruction of ecological shelter zones of the upper reaches of the Yangtze River became one of the most important tasks of Western Development strategy. This article, taking Zhaotong as an example, studies the functional regionalization of ecological shelter zones. The study supplies a case for functional regionalization of small and medium regions whose main tasks are environment reservation. With the guidance of theories of functional regionalization, and based on the analysis of Zhaotong＇s natural, ecological and socioeconomic factors, the paper suggests five principles for factors selection. These principles include： （1） reversing order evaluation; （2） selecting main factors; （3） keeping the integrality of administrative regions of towns; and （4） making the products acceptable by local government. To analyze spatial status of selected factors, LUCC data in 2002, 1：50,000 relief maps and town-unit socioeconomic statistical data in 2004 are used. RS and GIS tools are also applied to melt traditional and modern geographical methods. This would be useful to functional regionalization research in mountainous areas. As a conclusion, the leading functional regions of ecological conservation or economic development are suggested, respectively. Zhaotong city is divided into two-level functional regions. The first-level includes three leading functional regions and they will lead developing direction of sub-regions. The second-level includes eight sub-regions, which are policy implemented regions, and will supply guidance to Zhaotong＇s ecological shelter zones reconstruction.
文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM.
文摘The left ventricular regional systolic functions in patients with hypertrophic cardiomyopathy （HCM） were assessed by using quantitative tissue velocity imaging （QTVI）. Left ventricular （LV） regional myocardial velocity along long- and short-axis in 31 HCM patients and 20 healthy subjects were analyzed by QTVI, and the regional myocardial systolic peak velocities （MVS） were measured. Mean MVS at each level including mitral annular, basal, middle and apical segments were calculated. The ratio of MVS along long-axis to that along short-axis （Ri） at basal and middle segments of the LV posterior wall and ventricular septum were calculated. The results showed that mean MVS was slower at each level including mitral annular, basal, middle and apical segments in the HCM patients than that in the healthy subjects （P〈0.01）. There were no significant differences in mean MVS between obstructive and non-obstructive groups in HCM patients. MVS of all regional myocardial segments along long-axis in the HCM patients were significantly slower than that in the healthy subjects （P〈0.05）, but there was no significant difference in MVS of all regional myocardial segments along long-axis between hypertrophied and non-hypertrophied group in the HCM patients. Ri was significantly lower in the HCM patients than that in the healthy subjects. The LV regional myocardial contractility along long-axis was impaired not only in the hypertrophied wall but also in the non-hypertrophied one in patients with HCM, suggesting that QTVI can assess accurately LV regional systolic function in patient with HCM and provides a novel means for an early diagnosis before and independent of hypertrophy.
文摘Reasonable development and utilization of spatial resources in the coastal zone not only affects the development quality of the marine economy but also impacts the utilization efficiency of spatial resources,playing an important role in regional sustainable development.Depending on the natural,economic,and societal characteristics of a region,research topics such as using relevant methods to divide the coastline,proper spatial development of the coast,protecting coastal zones,and achieving higher spatial resource distribution efficiency have recently become hot topics in geographic research.Most of the scholars construct the evaluation index system from the perspective of economic and ecological factors and undertake some exploration of the division methods.However,the selection of indicators for a coastal zone needs a different and more scientific approach.There is a need for emphasizing the overall strategy of land-ocean integration in developing spatial resources in a coastal zone.Taking the coastal zone in Ningbo as an example,this paper develops a new evaluation framework and spatial function regionalization method that is used to divide the coastline and coastal zone.Based on the perspective of overall strategy for the land and ocean,we evaluate the suitability of coastline development.We then propose the spatial function regionalization of the coastal zone.Finally,based on the status quo of spatial development in Ningbo,we divide the coastal zone into ecological space,production space and living space,and propose adjustment directions and control requirements for the different types of spatial layouts.
文摘The value of tissue strain imaging （SI） in regional myocardial systolic and diastolic func tion assessment was studied. In 18 patients with nonobstructive hypertrophic cardiomyopathy （HCM） and 20 age-matched healthy subjects, regional myocardial longitudinal peak systolic strain in eject time （represented by εet） was measured at basal, mid and apical segments of septal, lateral and posterior walls of the left ventricle （LV） and compared between groups, εet had no significant difference between segments in control group （P〉0.05）, which displayed a decreasing trend from basal segments to apical ones. εet in the HCM group was significantly decreased （P（0. 05） as compared with that in the healthy group. In the HCM group, εet in the midseptum was significantly less than at the basal and apical septum, and was also less than at the rest LV walls in the same group （P〉0.01）. The systolic reversed εet was noticed in 35% of the hypertrophic segments in HCM group. Significantly negative correlation existed between the absolute value of εet and wall thickness in the midseptum （r= -0.83）. The post-systolic strain（PSS） segment number the and amplitudes in healthy group were significantly less than those in HCM group （P〈0.05）. Both regional myocardial systolic and diastolic functions were impaired in hypertrophic or non-hypertrophic segments in patients with the HCM, especially in hypertrophic segments. Strain imaging technique is a sensitive and accura tool in myocardial dysfunction assessment.
基金supported by the National Natural Science Foundation of China (40271011)
文摘The middle and lower reaches of the Tarim River are currently one of the main regions of ecological restoration in the arid areas of western China.Using the principles and method of landscape ecology,this study has chosen the fluvial corridor landscape in the middle and lower reaches of the Tarim River,and discusses the region’s ecologically functional regionalization system and issues related to its practical classification.On this basis the corresponding regionalizing principles and standards were developed which were used to qualitatively divide the three main landscapes as the ecologically functional areas in the drainage basin.The paper has also analyzed the characteristic of the study areas,and has put forward the measures for its ecological restoration.
基金supported by the National Nature Science Foundation of China(615111300816147104861273217)
文摘The process of urbanization is formed by regular movements of human beings. It yields different functional zones in a city, such as residential zone and commercial zone. Consequently, there exists a close connection between the human mobility pattern and the city＇s zones. However, it is not easy to collect large-scale society-wide data that can precisely capture the underlying relations between the individual＇s movement and the regional functions. Hence, our knowledge for understanding the basic patterns of human mobility is still limited. In order to discover the functions of different regions in a city, we propose an affinity based method in this paper. The affinity is a recently introduced metric for measuring the correlation of two connecting node in a complex network. The proposed model groups different functional zones by measuring user＇s arrival/departure distribution via relative entropy. In addition to this, we also identify the intensity of each functional zone by taking kernel density estimation （KDE） method. In the end, some experiments are conducted to evaluate our method with a large-scale real-life dataset, which consists of 3 million cellphone users＇ records from a period of one month. Our findings on the interaction between the mobility pattern and the regional functions can capture the city dynamics efficiently and provide a valuable reference for urban planners.
文摘The object of this article is to introduce new classes of meromorphic functions associated with conic regions. Several properties like the coefficient bounds, growth and distortion theorems, radii of starlikeness and convexity, partial sums, are investigated. Some consequences of the main results for the well-known classes of meromorphic functions are also pointed out.
基金National Natural Science Foundation of China,No.41571168Key Project of Philosophy and Social Science Foundation of Hunan Province,No.18ZDB015
文摘As the Rural Revitalization Strategy is gradually implemented, China’s rural areas are set to have more diverse function requirements. This paper selects the Changsha-Zhuzhou-Xiangtan region(Chang-Zhu-Tan) consisting of 23 county-level units) as a case study and looks at its economic development, agricultural product supply, social security and ecological service functions during 1996–2016. It then constructs an index system to evaluate the temporal evolution of the region’s rural functions. SPSS 19.0 and DPS 7.05 software, as well as Pearson’s correlation coefficient analysis, system clustering, optimal segmentation of ordered samples and other methods, are used to study the evolution traits, regional differentiation characteristics and driving forces of rural functions in the region. The results show, first of all, that the overall evolution trend is increasing in functions with periodic characteristics, the key nodes being 2000 and 2008. Second, there is clear geographical differentiation in the evolution of rural functions. The economic development function shows rapid growth in the urban agglomeration’s center and relatively weak growth at the periphery;the agricultural product supply function and ecological service function are concentrated in county-level units with abundant cultivated and forest land;and the social security function displays similar geographical differentiation to the economic development function. Overall, there is an obvious discrepancy in the degree of development of rural functions among county-level units of the Changsha-Zhuzhou-Xiangtan urban agglomeration;the rural functions of the agglomeration and peripheral county-level units have different development traits;and county-level units display functional differentiation. Third, rural functions have evolved as a result of interactions between various factors, such as natural resources, socio-economic conditions and local transport conditions. The new driving forces caused by urbanization are ultimately leading the evolution of rural functions toward multi-functional comprehensive development.
基金the Science and Technology Planning Project of Guangdong Province, China, No. 2008B080703041
文摘Regional homogeneity analysis of low-frequency blood oxygenation level-dependent signals from neighboring voxels enables the analysis of local neuronal synchrony. Both structural magnetic resonance imaging and resting-state functional magnetic resonance imaging scans were collected from nine Parkinson＇s disease patients with right resting tremor, and from eight age-matched normal controls. Regional homogeneity was compared between Parkinson＇s disease patients and controls. The results revealed that regional homogeneity was increased in several brain regions, including the right precuneus, right superior parietal gyrus, left anterior cingulate cortex, right middle frontal gyrus and right inferior frontal gyrus. Conversely, regional homogeneity was decreased in the cerebellar vermis in Parkinson＇s disease patients compared with healthy controls.
基金This research was funded by the Shandong Provincial Natural Science Foundation(grant number ZR202102240088).
文摘Population density functions have long been used to describe the spatial structure of regional population distributions.Several studies have been conducted to examine the population distribution in Shandong Province,China,but few have applied regional density functions to the analysis.Therefore,based on the 2000,2010,and 2020 population censuses,this study used monocentric and polycentric regional density functions to study the characteristics of population agglomeration and diffusion in Shandong.This is followed by an in-depth discussion based on population growth rate data and hot-and cold-spot analyses.The results showed that the Shandong Province population was spatially unevenly distributed.Population growth rates were higher in urban centers and counties,with more significant changes in population size in the eastern coastal areas than in the inland areas.As verified in this study,the logarithmic form of the single-center regional density function R2 was greater than 0.8,which was in line with the population spatial structure of Shandong Province.During the study period,the estimated population density of the regional center and the absolute value of the regional population density gradient both increased,indicating a clear and increasing trend of centripetal agglomeration of regional centers over the study period.Overall,the R2 value of the multicenter region density function was higher than that of the single-center region density function.The polycentric regional density function showed that the population density gradient of some centers had a downward trend,which reflected the spatial development trend of outward diffusion in these centers.Meanwhile,the variation in the estimated population density and the population density gradient exhibited differences in the central population distribution patterns at different levels.
基金Under the auspices of the National Science Foundation of China(No.41871119,41871209)
文摘As a result of rapid urbanization in China, urban sprawl has increased rapidly, and land-use regulation and smart urban growth are equally important. Spatial function regionalization can provide the scientific groundwork for the regulation of land use and protection. This paper probes the system of evaluation indices and applies the methods of spatial analysis and classification clustering to the calculation of the ecologically significant value and economically significant value in each evaluation unit. After use of a classification matrix integrated by the two significant values, city space can be divided into four functional types, namely, feasible development area, moderate development area, moderate conservation area and prohibited exploiting area, and these are the basis for spatial development and control.
文摘BACKGROUND： An increasing number of studies have shown the effects of aging in basic cognitive processing and higher cognitive functions using functional magnetic resonance imaging （fMRI）. However, little is known about the aging effects in diverse cognitive abilities, such as spatial learning and reasoning. OBJECTIVE： To investigate the effect of aging on spatial cognitive performance and regional brain activation based on fMRI. DESIGN, TIME, AND SETTING： A block design for fMRI observation. This study was performed at the fMRI Laboratory, Brain Science Research Center, Korea Advanced Institute of Science and Technology from March 2006 to May 2009. PARTICIPANTS： Eight right-handed, male, college students in their 20s （mean age 21.5 years） and six right-handed, male, adults in their 40s （mean age 45.7 years）, who graduated from college, participated in the study. All subjects were healthy and had no prior history of psychiatric or neurological disorders. METHODS： A spatial task was presented while brain images were acquired using a 3T fMRI system （ISOL Technology, Korea）. The spatial tasks involved selecting a shape that corresponded to a given figure using four examples, as well as selecting a development figure of a diagram. MAIN OUTCOME MEASURES： The accuracy rate （number of correct answers/total number of items x 100%） of spatial tasks was calculated. Using the subtraction procedure, the activated areas in the brain during spatial tasks were color-coded by T-score. The double subtraction method was used to analyze the effect of aging between the two age groups （20s versus 40s）. RESULTS： The cerebellum, occipital lobe, parietal lobe, and frontal lobe were similarly activated in the two age groups. Increased brain activations, however, were observed in bilateral parietal and superior frontal lobes of the younger group. More activation was observed in bilateral middle frontal and right inferior frontal lobes in the older group. Compared with the older group, the younger men exhibited greater spatial performance （P = 0.012）. CONCLUSION： Reduced cognitive function correlated with decreased activation areas in the parietal lobe and altered activation in the frontal lobe.
基金the Open Research Fund Program of Shenzhen Key Laboratory of Spatial Smart Sensing and Services%sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry(grant number 50-20150618)%National Natural Science Foundation of China (grant numbers 41001220, 51378512, 41571397, and 41501442)This work was also supported by the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund
文摘This article introduces a novel low rank approximation (LRA)-based model to detect the functional regions with the data from about 15 million social media check-in records during a year-long period in Shanghai, China. We identified a series of latent structures, named latent spatio-temporal activity structures. While interpreting these structures, we can obtain a series of underlying associations between the spatial and temporal activity patterns. Moreover, we can not only reproduce the observed data with a lower dimensional representative, but also project spatio-temporal activity patterns in the same coordinate system. With the K-means clustering algorithm, five significant types of clusters that are directly annotated with a combination of temporal activities can be obtained, providing a clear picture of the correlation between the groups of regions and different activities at different times during a day. Besides the commercial and transportation dominant areas, we also detected two kinds of residential areas, the developed residential areas and the developing residential areas.We further interpret the spatial distribution of these clusters using urban form analytics. The results are highly consistent with the government planning in the same periods, indicating that our model is applicable to infer the functional regions from social media check-in data and can benefit a wide range of fields, such as urban planning, public services, and location-based recommender systems.
基金supported by the National Natural Science Foundation of China (30830046,30625024, 81171286)the National Science and Technology Program of China (2007BAI17B02)+2 种基金the National Basic Research Development Program (973 Program) of China(2009CB918303)the Science and Technology Program of the Ministry of Education, China (20090162110011)the National High-Tech Research and Development Program of China (863 program:2008AA02Z408)
文摘Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder （PTSD）. Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging （fMRI）, between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent （BOLD） fMRI and analyzed using the measure of regional homogeneity （ReHo） during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
基金supported by the National Natural Science Foundation of China (Nos.41374023,41131067,41474019)the National 973 Project of China (No.2013CB733302)+2 种基金the China Postdoctoral Science Foundation (No.2016M602301)the Key Laboratory of Geospace Envi-ronment and Geodesy,Ministry of Education,Wuhan University (No.15-02-08)the State Scholarship Fund from Chinese Scholarship Council (No.201306270014)
文摘The application of Tikhonov regularization method dealing with the ill-conditioned problems in the regional gravity field modeling by Poisson wavelets is studied. In particular, the choices of the regularization matrices as well as the approaches for estimating the regularization parameters are investigated in details. The numerical results show that the regularized solutions derived from the first-order regularization are better than the ones obtained from zero-order regularization. For cross validation, the optimal regularization parameters are estimated from L-curve, variance component estimation（VCE） and minimum standard deviation（MSTD） approach, respectively, and the results show that the derived regularization parameters from different methods are consistent with each other. Together with the firstorder Tikhonov regularization and VCE method, the optimal network of Poisson wavelets is derived, based on which the local gravimetric geoid is computed. The accuracy of the corresponding gravimetric geoid reaches 1.1 cm in Netherlands, which validates the reliability of using Tikhonov regularization method in tackling the ill-conditioned problem for regional gravity field modeling.
基金financially supported by the State Key Development Program for Basic Research of China(973 Program,Grant No.2013CB036204)
文摘According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action ofbiaxial load after the comparison of the stress distribution characteristics of the ballast track subgrade bed structures for high-speed railway under the action of uniaxial load and biaxial load. The loading threshold value （high-cycle long-term dynamic strength） under the circum- stance where the cumulative deformation of subgrade structure gradually develops and finally reaches the convergent state, and its relationship with the foundation coefficient K30 were deduced, based on the characteristics of cumulative defor- mation evolution obtained from the unit structure filling model test under the action of cyclic loading. In view of structure stability and frost resistance requirements of the railway subgrade in cold regions, technical conditions to maintain good service performance of subgrade structure of high-speed railway ballasted track are discussed and analyzed. Study results show that the additive effect manifests itself obviously for railway train bogies under the action of biaxial load than uni- axial load, which has a significant dynamic effect on the subgrade bed bottom and a slight effect on the surface layer. Thus, the adoption of a biaxial load model in the design of a high-speed railway subgrade accurately reflects the vehicle load. Pursuant to the structure design principle, the design method of the subgrade structure of high-speed railway ballasted track is proposed to meet the technical requirements such as structural strength, bearing stiffness and high-cyclic and long-term stability. Technical indicators are obtained for the variation of thickness of the surface layer of reinforced sub- grade bed in the double-layer subgrade mode along with the change of K30 at the subgrade bed bottom. The double-layer structure mode of ＂closure on the upper layer and drainage on the lower layer＂ was proposed in order to meet the water- proofing and drainage requirements of the upper layer of the subgrade bed in cold regions. A dense-framework graded gravel filler with weak water permeability at a coefficient of 10 4 cm/s is used on the upper layer and the void-framework graded gravel filler at the water permeability coefficient of 10 2 cm/s is adopted on the lower layer.
