The year of 2018 marks the 65th anniversary of the discovery of DNA double helix and the 15th anniversary of the successful completion of the international Human Genome Project (HGP),the two revolutions in life scienc...The year of 2018 marks the 65th anniversary of the discovery of DNA double helix and the 15th anniversary of the successful completion of the international Human Genome Project (HGP),the two revolutions in life sciences (Sharp, 2014). The year also sees the effective implementation of the "1%Program", the Chinese contribution to the reference sequence of the human genome,which coincides with the 40th anniversary of the founding of the Genetics Society of China, one of the most influential national academic organizations in China.展开更多
Gene mutation(e.g.substitution,insertion and deletion)and related phenotype information are important bio-medical knowledge.Many biomedical databases(e.g.OMIM)incorporate such data.However,few studies have examined th...Gene mutation(e.g.substitution,insertion and deletion)and related phenotype information are important bio-medical knowledge.Many biomedical databases(e.g.OMIM)incorporate such data.However,few studies have examined the quality of this data.In the current study,we examined the quality of protein single-point mutations in the OMIM and identified whether the cor-responding reference sequences align with the muta-tion positions.Our results show that close to 20%of mutation data cannot be mapped to a single reference sequence.The failed mappings are caused by position conflict,site shifting(peptide,N-terminal methionine)and other types of data error.We propose a preliminary model to resolve such inconsistency in the OMIM database.展开更多
The assessment of water security is an important content in the security management of water resources due to the fact that the state of water security directly affects both the sustainable development of regional eco...The assessment of water security is an important content in the security management of water resources due to the fact that the state of water security directly affects both the sustainable development of regional economy and the improvement on the living quality of mankind.Grey associative analysis is introduced and applied to assessment of water security on the basis of grey characteristics of the assessment index system of water security.As a case study shows,grey associative analysis is used for evaluating water security of some provinces in China,and the satisfactory assessment results are obtained.The sequence of provinces in China with regard to water security from good to poor is obtained and,moreover,the water security level of each region is also confirmed.The results obtained accord with the actual state of each region.They are of practical significance and can be used to guide the management of regional water security and a sustainable development of the economy therein.At the same time,the results demonstrate that grey associative analysis provides a new method for assessing water security quantitatively but needs a further study.展开更多
Cultivated Triticeae members,including wheat,barley,and rye,are at the center of attention of plant biologists due to their significant contribution to global food security.The completion of the first reference genome...Cultivated Triticeae members,including wheat,barley,and rye,are at the center of attention of plant biologists due to their significant contribution to global food security.The completion of the first reference genome sequence of bread wheat(IWGSC,2018)was a major leap forward for the wheat scientific community.展开更多
文摘The year of 2018 marks the 65th anniversary of the discovery of DNA double helix and the 15th anniversary of the successful completion of the international Human Genome Project (HGP),the two revolutions in life sciences (Sharp, 2014). The year also sees the effective implementation of the "1%Program", the Chinese contribution to the reference sequence of the human genome,which coincides with the 40th anniversary of the founding of the Genetics Society of China, one of the most influential national academic organizations in China.
基金supported by grants from the Talents Develop-mental Fund of Shanghai in 2011 to ZF Li and the National High Technology Research and Development Program of China(863 Program)to XY Zhang(Grant Nos.2007AA02Z332 and 2008AA02Z126).
文摘Gene mutation(e.g.substitution,insertion and deletion)and related phenotype information are important bio-medical knowledge.Many biomedical databases(e.g.OMIM)incorporate such data.However,few studies have examined the quality of this data.In the current study,we examined the quality of protein single-point mutations in the OMIM and identified whether the cor-responding reference sequences align with the muta-tion positions.Our results show that close to 20%of mutation data cannot be mapped to a single reference sequence.The failed mappings are caused by position conflict,site shifting(peptide,N-terminal methionine)and other types of data error.We propose a preliminary model to resolve such inconsistency in the OMIM database.
基金This project is supported by the Hubei Key Laboratory Hydropower Construction and Management Project,China Three Gorges University,and Center of China Central Economic Development in Nanchang University
文摘The assessment of water security is an important content in the security management of water resources due to the fact that the state of water security directly affects both the sustainable development of regional economy and the improvement on the living quality of mankind.Grey associative analysis is introduced and applied to assessment of water security on the basis of grey characteristics of the assessment index system of water security.As a case study shows,grey associative analysis is used for evaluating water security of some provinces in China,and the satisfactory assessment results are obtained.The sequence of provinces in China with regard to water security from good to poor is obtained and,moreover,the water security level of each region is also confirmed.The results obtained accord with the actual state of each region.They are of practical significance and can be used to guide the management of regional water security and a sustainable development of the economy therein.At the same time,the results demonstrate that grey associative analysis provides a new method for assessing water security quantitatively but needs a further study.
基金the National Natural Science Foundation of China(32361143512)the State Key Laboratory of Crop Gene Resource and Breedingthe National Key R&D Program of China(no.2024YFF1000600).
文摘Cultivated Triticeae members,including wheat,barley,and rye,are at the center of attention of plant biologists due to their significant contribution to global food security.The completion of the first reference genome sequence of bread wheat(IWGSC,2018)was a major leap forward for the wheat scientific community.
