Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients re...Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.展开更多
In Energy Harvesting Wireless Sensor Networks(EHWSN),the communication protocol will directly affect the final performance of the network,so it is necessary to study the communication protocol based on EHWSN.In this p...In Energy Harvesting Wireless Sensor Networks(EHWSN),the communication protocol will directly affect the final performance of the network,so it is necessary to study the communication protocol based on EHWSN.In this paper,for the low-cost fixed clustering problem,a fixed clustering protocol RRCEH is based on random relaying.Our proposed RRCEH abandons the inefficient inter-cluster communication method of the traditional fixed clustering protocol.To coordinate the data upload of the cluster head,RRCEH allocates different random relay vectors to each ring area of the network,and combines all the random relay vectors into a random relay matrix of RRCEH.In each communication round,the cluster head node randomly selects its relay target node to send data according to the probability distribution in the random relay vector in the area.For two different cluster head configuration scenarios,by optimizing the random relay matrix,RRCEH can effectively reduce the network's configuration requirements for cluster head energy harvesting capability,thus reducing the deployment cost of EHWSN.展开更多
The Swarm intelligence algorithm is a very prevalent field in which some scholars have made outstanding achievements.As a representative,Slime mould algorithm(SMA)is widely used because of its superior initial perform...The Swarm intelligence algorithm is a very prevalent field in which some scholars have made outstanding achievements.As a representative,Slime mould algorithm(SMA)is widely used because of its superior initial performance.Therefore,this paper focuses on the improvement of the SMA and the mitigation of its stagnation problems.For this aim,the structure of SMA is adjusted to develop the efficiency of the original method.As a stochastic optimizer,SMA mainly stimulates the behavior of slime mold in nature.For the harmony of the exploration and exploitation of SMA,the paper proposed an enhanced algorithm of SMA called ECSMA,in which two mechanisms are embedded into the structure:elite strategy,and chaotic stochastic strategy.The details of the original SMA and the two introduced strategies are given in this paper.Then,the advantages of the improved SMA through mechanism comparison,balance-diversity analysis,and contrasts with other counterparts are validated.The experimental results demonstrate that both mechanisms have a significant enhancing effect on SMA.Also,SMA is applied to four structural design issues of the welded beam design problem,PV design problem,I-beam design problem,and cantilever beam design problem with excellent results.展开更多
In this paper the authors consider the operational problem of optimal signalling and control,called control-coding capacity(with feedback),C_(FB) in bits/second,of discrete-time nonlinear partially observable stochast...In this paper the authors consider the operational problem of optimal signalling and control,called control-coding capacity(with feedback),C_(FB) in bits/second,of discrete-time nonlinear partially observable stochastic systems in state space form,subject to an average cost constraint.C_(FB) is the maximum rate of encoding signals or messages into randomized controller-encoder strategies with feedback,which control the state of the system,and reproducing the messages at the output of the system using a decoder or estimator with arbitrary small asymptotic error probability.In the first part of the paper,the authors characterize C_(FB) by an information theoretic optimization problem of maximizing directed information from the inputs to the outputs of the system,over randomized strategies(controller-encoders).The authors derive equivalent characterizations of C_(FB),using randomized strategies generated by either uniform or arbitrary distributed random variables(RVs),sufficient statistics,and a posteriori distributions of nonlinear filtering theory.In the second part of the paper,the authors analyze C_(FB) for linear-quadratic Gaussian partially observable stochastic systems(LQG-POSSs).The authors show that randomized strategies consist of control,estimation and signalling parts,and the sufficient statistics are,two Kalman-filters and an orthogonal innovations process.The authors prove a semi-separation principle which states,the optimal control strategy is determined explicitly from the solution of a control matrix difference Riccati equation(DRE),independently of the estimation and signalling strategies.Finally,the authors express the optimization problem of C_(FB) in terms of two filtering matrix DREs,a control matrix DRE,and the covariance of the innovations process.Throughout the paper,the authors illustrate that the expression of C_(FB) includes as degenerate cases,problems of stochastic optimal control and channel capacity of information transmission.展开更多
文摘Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.
文摘In Energy Harvesting Wireless Sensor Networks(EHWSN),the communication protocol will directly affect the final performance of the network,so it is necessary to study the communication protocol based on EHWSN.In this paper,for the low-cost fixed clustering problem,a fixed clustering protocol RRCEH is based on random relaying.Our proposed RRCEH abandons the inefficient inter-cluster communication method of the traditional fixed clustering protocol.To coordinate the data upload of the cluster head,RRCEH allocates different random relay vectors to each ring area of the network,and combines all the random relay vectors into a random relay matrix of RRCEH.In each communication round,the cluster head node randomly selects its relay target node to send data according to the probability distribution in the random relay vector in the area.For two different cluster head configuration scenarios,by optimizing the random relay matrix,RRCEH can effectively reduce the network's configuration requirements for cluster head energy harvesting capability,thus reducing the deployment cost of EHWSN.
基金supported in part by the National Natural Science Foundation of China(J2124006,62076185)。
文摘The Swarm intelligence algorithm is a very prevalent field in which some scholars have made outstanding achievements.As a representative,Slime mould algorithm(SMA)is widely used because of its superior initial performance.Therefore,this paper focuses on the improvement of the SMA and the mitigation of its stagnation problems.For this aim,the structure of SMA is adjusted to develop the efficiency of the original method.As a stochastic optimizer,SMA mainly stimulates the behavior of slime mold in nature.For the harmony of the exploration and exploitation of SMA,the paper proposed an enhanced algorithm of SMA called ECSMA,in which two mechanisms are embedded into the structure:elite strategy,and chaotic stochastic strategy.The details of the original SMA and the two introduced strategies are given in this paper.Then,the advantages of the improved SMA through mechanism comparison,balance-diversity analysis,and contrasts with other counterparts are validated.The experimental results demonstrate that both mechanisms have a significant enhancing effect on SMA.Also,SMA is applied to four structural design issues of the welded beam design problem,PV design problem,I-beam design problem,and cantilever beam design problem with excellent results.
文摘In this paper the authors consider the operational problem of optimal signalling and control,called control-coding capacity(with feedback),C_(FB) in bits/second,of discrete-time nonlinear partially observable stochastic systems in state space form,subject to an average cost constraint.C_(FB) is the maximum rate of encoding signals or messages into randomized controller-encoder strategies with feedback,which control the state of the system,and reproducing the messages at the output of the system using a decoder or estimator with arbitrary small asymptotic error probability.In the first part of the paper,the authors characterize C_(FB) by an information theoretic optimization problem of maximizing directed information from the inputs to the outputs of the system,over randomized strategies(controller-encoders).The authors derive equivalent characterizations of C_(FB),using randomized strategies generated by either uniform or arbitrary distributed random variables(RVs),sufficient statistics,and a posteriori distributions of nonlinear filtering theory.In the second part of the paper,the authors analyze C_(FB) for linear-quadratic Gaussian partially observable stochastic systems(LQG-POSSs).The authors show that randomized strategies consist of control,estimation and signalling parts,and the sufficient statistics are,two Kalman-filters and an orthogonal innovations process.The authors prove a semi-separation principle which states,the optimal control strategy is determined explicitly from the solution of a control matrix difference Riccati equation(DRE),independently of the estimation and signalling strategies.Finally,the authors express the optimization problem of C_(FB) in terms of two filtering matrix DREs,a control matrix DRE,and the covariance of the innovations process.Throughout the paper,the authors illustrate that the expression of C_(FB) includes as degenerate cases,problems of stochastic optimal control and channel capacity of information transmission.
