期刊文献+
共找到1,435篇文章
< 1 2 72 >
每页显示 20 50 100
DYNAMIC CHARACTERISTIC ANALYSIS OF FUZZY-STOCHASTIC TRUSS STRUCTURES BASED ON FUZZY FACTOR METHOD AND RANDOM FACTOR METHOD 被引量:2
1
作者 马娟 陈建军 +1 位作者 徐亚兰 江涛 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2006年第6期823-832,共10页
A new fuzzy stochastic finite element method based on the fuzzy factor method and random factor method is given and the analysis of structural dynamic characteristic for fuzzy stochastic truss structures is presented.... A new fuzzy stochastic finite element method based on the fuzzy factor method and random factor method is given and the analysis of structural dynamic characteristic for fuzzy stochastic truss structures is presented. Considering the fuzzy randomness of the structural physical parameters and geometric dimensions simultaneously, the structural stiffness and mass matrices axe constructed based on the fuzzy factor method and random factor method; from the Rayleigh's quotient of structural vibration, the structural fuzzy random dynamic characteristic is obtained by means of the interval arithmetic; the fuzzy numeric characteristics of dynamic characteristic axe then derived by using the random variable's moment function method and algebra synthesis method. Two examples axe used to illustrate the validity and rationality of the method given. The advantage of this method is that the effect of the fuzzy randomness of one of the structural parameters on the fuzzy randomness of the dynamic characteristic can be reflected expediently and objectively. 展开更多
关键词 fuzzy stochastic truss fuzzy factor method random factor method fuzzy random dynamic characteristic
在线阅读 下载PDF
SEISMIC RANDOM VIBRATION ANALYSIS OF STOCHASTIC STRUCTURES USING RANDOM FACTOR METHOD 被引量:2
2
作者 GAO Wei KESSISSOGLOU Nicoe J 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第1期1-8,共8页
Seismic random vibration analysis of stochastic truss structures is presented.A new method called random factor method is used for dynamic analysis of structures with uncertain parameters,due to variability in their m... Seismic random vibration analysis of stochastic truss structures is presented.A new method called random factor method is used for dynamic analysis of structures with uncertain parameters,due to variability in their material properties and geometry.Using the random factor method,the natural frequencies and modeshapes of a stochastic structure can be respectively described by the product of two parts,corresponding to the random factors of the structural parameters with uncertainty,and deterministic values of the natural frequencies and modeshapes obtained by conventional finite element analysis.The stochastic truss structure is subjected to stationary or non-stationary random earthquake excitation.Computational expressions for the mean and standard deviation of the mean square displacement and mean square stress are developed by means of the random variable's functional moment method and the algebra synthesis method.An antenna and a truss bridge are used as practical engineering examples to illustrate the application of the random factor method in the seismic response analysis of random structures under stationary or non-stationary random earthquake excitation. 展开更多
关键词 Seismic random vibration Uncertainty structures random factor method Non-stationary ground motion
在线阅读 下载PDF
Estimation of random errors for lidar based on noise scale factor 被引量:2
3
作者 王欢雪 刘建国 张天舒 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第8期386-390,共5页
Estimation of random errors, which are due to shot noise of photomultiplier tube(PMT) or avalanche photodiode(APD) detectors, is very necessary in lidar observation. Due to the Poisson distribution of incident electro... Estimation of random errors, which are due to shot noise of photomultiplier tube(PMT) or avalanche photodiode(APD) detectors, is very necessary in lidar observation. Due to the Poisson distribution of incident electrons, there still exists a proportional relationship between standard deviation and square root of its mean value. Based on this relationship,noise scale factor(NSF) is introduced into the estimation, which only needs a single data sample. This method overcomes the distractions of atmospheric fluctuations during calculation of random errors. The results show that this method is feasible and reliable. 展开更多
关键词 atmospheric optics LIDAR random error noise factor noise scale factor
原文传递
Efficacy and safety of nerve growth factor for the treatment of neurological diseases:a meta-analysis of 64 randomized controlled trials involving 6,297 patients 被引量:12
4
作者 Meng Zhao Xiao-yan Li +1 位作者 Chun-ying Xu Li-ping Zou 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第5期819-828,共10页
OBJECTIVE: China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug. The... OBJECTIVE: China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug. The goal of this article is to evaluate comprehensively the efficacy and safety of nerve growth factor for the treatment of neurological diseases. DATA RETRIEVAL: A computer-based retrieval was performed from six databases, including the Cochrane Library, PubMed, EMBASE, Sino Med, CNKI, and the VIP database, searching from the clinical establishment of nerve growth factor for treatment until December 31, 2013. The key words for the searches were "nerve growth factor, randomized controlled trials" in Chinese and in English. DATA SELECTION: Inclusion criteria: any study published in English or Chinese referring to randomized controlled trials of nerve growth factor; patients with neurological diseases such as peripheral nerve injury, central nerve injury, cranial neuropathy, and nervous system infections; patients older than 7 years; similar research methods and outcomes assessing symptoms; and measurement of nerve conduction velocities. The meta-analysis was conducted using Review Manager 5.2.3 software. MAIN OUTCOME MEASURES: The total effective rate, the incidence of adverse effects, and the nerve conduction velocity were recorded for each study. RESULTS: Sixty-four studies involving 6,297 patients with neurological diseases were included. The total effective rate in the group treated with nerve growth factor was significantly higher than that in the control group (P 〈 0.0001, RR: 1.35, 95%CI: 1.30-1.40). The average nerve conduction velocity in the nerve growth factor group was significantly higher than that in the control group (P 〈 0.00001, MD. 4.59 m/s, 95%CI: 4.12-5.06). The incidence of pain or sclero- ma at the injection site in the nerve growth factor group was also higher than that in the control group (P 〈 0.00001, RR: 6.30, 95%CI: 3.53-11.27), but such adverse effects were mild. CONCLUSION: Nerve growth factor can significantly improve nerve function in patients with nervous system disease and is safe and effective. 展开更多
关键词 nerve regeneration neurological diseases nerve growth factor randomized controlledtrials META-ANALYSIS adverse effects nerve conduction velocity neural regeneration
暂未订购
Entropy Production in a Non-Isolated Thermodynamic System Taking into Account Regular Factors of Nonrandom Nature
5
作者 A. Yu. Khlestkov Yu. A. Khlestkov +2 位作者 N. Yu. Lukashina M. Yu. Lukashin P. Yu. Lukashin 《Journal of Modern Physics》 2020年第3期343-354,共12页
The work illustrates the impossibility of decreasing entropy in a strictly random thermodynamic process in a non-isolated system using the example of heating a planet by solar radiation flux without and taking into ac... The work illustrates the impossibility of decreasing entropy in a strictly random thermodynamic process in a non-isolated system using the example of heating a planet by solar radiation flux without and taking into account its rotation around its own axis. That is, the second law of thermodynamics formulated for isolated systems continues to govern such systems. We have shown that in order to achieve a stationary state at lower values of temperature and entropy far from thermodynamic equilibrium at a maximum of temperature and entropy, it is necessary to have regular factors of nonrandom nature, one of which in this example is the rotation of the planet around its own axis. This means that the reason for the appearance of ordered structured objects in non-isolated thermodynamic systems is not the random process itself, but the action of dynamic control mechanisms, such as periodic external influences, nonlinear elements with positive feedback, catalysts for chemical reactions, etc. We present the plots with dependences of temperature and entropy versus time in non-isolated systems with purely random processes and in the presence of a control factor of non-random nature-rotation. 展开更多
关键词 random Process Non-Isolated Systems Entropy Ordered Structures Regular factors of Non-random NATURE
在线阅读 下载PDF
Mendelian Randomization Study of Causal Relationship between Inflammatory Factors and Vascular Dementia and Chinese Herbal Medicines Screening for Prevention and Treatment
6
作者 Jinzhi Zhang Wei Chen +8 位作者 Guifeng Zhuo Chun Yao Mingyang Su Bingmao Yuan Xiaomin Zhu Zizhen Zhou Fengyi Lei Yulan Fu Lin Wu 《Journal of Biosciences and Medicines》 2024年第10期270-284,共15页
Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine predic... Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their characteristics including four natures, five flavors, channel tropism and treatment efficiency were cold, warm, neutral, pungent, sweet, bitter, lung meridian, spleen meridian, liver meridian, kidney meridian and clearing heat. Among them, Siraitia grosvenorii, Poria with hostwood, Perilla frutescens, and Radix Platycodi were all medicine and food homologous Chinese herbal medicines. Conclusions: The increase of CXCL10 and CXCL5 expression levels can increase the risk of VD, and the increase of IL-13 and IL-20 RA expression levels can reduce the risk of VD. Siraitia grosvenorii and other Chinese herbal medicines might be potential sources of therapeutic drugs for the treatment of VD. Medicine and food homologous Chinese herbal medicines, such as Siraitia grosvenorii, Poria with hostwood, Perilla frutescens, and Radix Platycodi, may help the elderly population with corresponding Traditional Chinese Medicine (TCM) constitutions to prevent VD. 展开更多
关键词 Inflammatory factors Vascular Dementia Mendelian randomization Study Causal Association Chinese Medicine Prediction Medicine and Food Homology
暂未订购
滑溜水对深层煤岩气解吸界面的调控机制
7
作者 罗懿 方燕俊 乔倩瑜 《断块油气田》 北大核心 2026年第1期147-153,共7页
针对大牛地气田深层煤岩气开发过程中深层煤岩气(甲烷)解吸困难、压后产能低等问题,通过开展甲烷解吸性能测试、岩心伤害测试、返排液滞留测试等实验,研究滑溜水对煤岩润湿性能、微观结构、表面电荷性质以及甲烷解吸性能的影响,明确滑... 针对大牛地气田深层煤岩气开发过程中深层煤岩气(甲烷)解吸困难、压后产能低等问题,通过开展甲烷解吸性能测试、岩心伤害测试、返排液滞留测试等实验,研究滑溜水对煤岩润湿性能、微观结构、表面电荷性质以及甲烷解吸性能的影响,明确滑溜水对甲烷解吸影响机理,同时采用曲面响应法(RSM),明确滑溜水对甲烷解吸性能影响的主控因素和预测主控因素边界条件,并在此基础上引入随机森林(RF)不确定性评估,选择对参数扰动不敏感的稳健解,增加结论可信度。结果表明,滑溜水对甲烷的解吸是竞争吸附作用的结果,滑溜水进入煤岩基质后占据甲烷吸附位点,促进甲烷解吸。在促解吸过程中,滑溜水的矿化度、与煤岩接触角、黏度、Zeta电位均会导致甲烷解吸量的变化。对于滑溜水性能指标,影响甲烷解吸过程的主控因素是矿化度、接触角,滑溜水与煤岩的接触角应控制在50°~70°,矿化度应低于5×10^(4) mg/L,有利于甲烷解吸。研究成果在同类煤岩气开发过程中具有重要的推广意义。 展开更多
关键词 深层煤岩气 曲面响应 随机森林 滑溜水 主控因素
在线阅读 下载PDF
炎症因子与类风湿关节炎的关系:芬兰R10数据库及全基因组关联大样本分析 被引量:1
8
作者 姜凯 戎义发 +4 位作者 贾海峰 李翰政 卢博文 梁学振 李刚 《中国组织工程研究》 北大核心 2026年第10期2629-2640,共12页
背景:类风湿关节炎是一种慢性、系统性的自身免疫性疾病,它的发病机制涉及多种炎症因子和代谢物,但因果关系尚不明确。国内类风湿关节炎的诊断和治疗水平近年来虽有提高,但仍有部分患者因缺乏早期诊断和规范治疗而致残。目的:采用孟德... 背景:类风湿关节炎是一种慢性、系统性的自身免疫性疾病,它的发病机制涉及多种炎症因子和代谢物,但因果关系尚不明确。国内类风湿关节炎的诊断和治疗水平近年来虽有提高,但仍有部分患者因缺乏早期诊断和规范治疗而致残。目的:采用孟德尔随机化方法评估炎症因子与类风湿关节炎之间的潜在因果关系,为临床研究提供新的支持和角度,以期填补类风湿关节炎发病机制与炎症因子关系的空缺,为治疗和预防类风湿关节炎提供新的潜在靶点和指导。方法:疾病数据使用了来自一项芬兰R10数据库的13621例类风湿关节炎患者和262844例健康对照者的遗传数据;91种炎症因子来自全基因组关联研究11个队列的荟萃分析,共有14824名欧洲血统参与者。正向孟德尔随机化分析以P<5×10^(-6)来识别炎症因子和类风湿关节炎相关的工具变量;反向孟德尔随机化分析以P<5×10^(-8)来识别类风湿关节炎和炎症因子相关的工具变量;正向和反向连锁不平衡参数均设为0.001,遗传距离设为10000 kb,只考虑F统计量>10的工具变量,之后去除混杂因素。采用逆方差加权方法、MR-Egger、加权中位数、简单众数和加权众数等方法研究91个炎症因子与类风湿关节炎之间的因果关系,主要以逆方差加权方法为主,P<0.05;异质性和水平多效性P>0.05,以排除异质性和水平多效性;并且进行反向孟德尔随机化分析,以排除反向因果。结果与结论:(1)C-C趋化因子23(OR=0.921,P=0.006)、成纤维细胞生长因子19(OR=0.906,P=0.046)、白细胞介素12亚单位β(OR=0.899,P=0.009)、白细胞介素2(OR=0.889,P=0.024)、白血病抑制因子受体(OR=0.876,P=0.047)对类风湿关节炎起保护作用;(2)C-C趋化因子19(OR=1.118,P=0.032)、C-C趋化因子4(OR=1.107,P=0.004)、白细胞介素7(OR=1.211,P=0.018)、肿瘤坏死因子(OR=1.119,P=0.040)对类风湿关节炎起危险作用;(3)上述结果为炎症因子在类风湿关节炎中的作用提供了新的视角和证据,弥补了该领域的空缺,并可能为预防和治疗类风湿关节炎带来新策略。 展开更多
关键词 孟德尔随机化 炎症因子 类风湿关节炎 因果关系 全基因组关联研究 单核苷酸多态性 保护性因子 危险性因子
暂未订购
结核性支气管扩张症患者转归情况及其影响因素研究
9
作者 汪雪 杨程茗 +1 位作者 王子云 周忠 《中国全科医学》 北大核心 2026年第5期606-611,共6页
背景结核性支气管扩张症是结核病的重要后遗症之一,目前关于结核性支气管扩张症患者预后的具体影响因素尚未十分明确。目的了解结核性支气管扩张症患者转归情况及影响因素,为改善患者预后提供科学依据。方法选取2023年4月—2024年4月在... 背景结核性支气管扩张症是结核病的重要后遗症之一,目前关于结核性支气管扩张症患者预后的具体影响因素尚未十分明确。目的了解结核性支气管扩张症患者转归情况及影响因素,为改善患者预后提供科学依据。方法选取2023年4月—2024年4月在贵阳市公共卫生救治中心住院的结核性支气管扩张症患者337例,对其出院后6个月的转归情况进行电话随访,并将其分为转归良好和转归不良。自制资料采集表,通过查阅病历收集临床资料。使用随机森林模型和LASSO回归筛选和分析转归情况的影响因素并对其重要性进行排序。结果337例结核性支气管扩张症患者转归不良发生率为41.2%(139/337)。转归良好和转归不良患者年龄、文化程度、BMI、既往吸烟、第1秒用力呼气量占预计值的百分比(FEV1%pred)、肺泡灌洗、合并慢性肺源性心脏病、合并慢性阻塞性肺疾病、合并高血压、铜绿假单胞菌感染、出院后吸烟、出院后饮酒、缺乏日常运动、独居、未按医嘱服药及出院白介素6(IL-6)、出院超敏C反应蛋白(hs-CRP)水平比较,差异均有统计学意义(P<0.05)。将单因素分析中有意义的变量进行LASSO回归模型分析,共筛选出9个变量。随机森林模型结果显示,各影响因素重要性排序依次为:未按医嘱服药、出院后吸烟、缺乏日常运动、文化程度、合并慢性肺源性心脏病、出院IL-6、年龄、出院后饮酒、独居。多因素Logistic回归分析结果显示,未按医嘱服药(OR=8.394,95%CI=3.323~21.203)、出院后吸烟(OR=5.294,95%CI=2.313~12.116)、缺乏日常运动(OR=4.555,95%CI=2.206~9.406)、合并慢性肺源性心脏病(OR=4.331,95%CI=2.012~9.323)、出院IL-6(OR=1.054,95%CI=1.018~1.091)和年龄≥80岁(OR=5.246,95%CI=1.097~25.077)是结核性支气管扩张症患者转归的危险因素(P<0.05),文化程度为初等教育(OR=0.358,95%CI=0.143~0.898)和中等教育(OR=0.202,95%CI=0.074~0.554)是结核性支气管扩张症患者转归的保护因素(P<0.05)。结论结核性支气管扩张症患者转归不良发生率较高,未按医嘱服药、出院后吸烟、缺乏日常运动、合并慢性肺源性心脏病、出院IL-6、年龄≥80岁、文化程度是结核性支气管扩张症的重要影响因素,可根据影响因素采取针对性措施。 展开更多
关键词 结核性支气管扩张症 转归 影响因素 随机森林模型
暂未订购
胃食管反流病和胰腺炎的因果关联:孟德尔随机化研究和共定位分析
10
作者 冯彬彬 王天麟 +4 位作者 韩俊泉 曲鹏飞 贺燕丽 杨朝帅 王红 《胃肠病学和肝病学杂志》 2026年第1期82-88,共7页
目的通过孟德尔随机化(Mendelian randomization,MR)研究和共定位分析,探讨胃食管反流病(gastroesophageal reflux disease,GERD)与胰腺炎之间的潜在因果关联。方法使用公开的全基因组关联研究(Genome-Wide Association Study,GWAS)的... 目的通过孟德尔随机化(Mendelian randomization,MR)研究和共定位分析,探讨胃食管反流病(gastroesophageal reflux disease,GERD)与胰腺炎之间的潜在因果关联。方法使用公开的全基因组关联研究(Genome-Wide Association Study,GWAS)的汇总数据进行分析。通过单变量和多变量MR分析方法,评估GERD与急性胰腺炎(acute pancreatitis,AP)或慢性胰腺炎(chronic pancreatitis,CP)之间的因果关联。并通过共定位分析,评估GERD与AP或CP之间是否存在共同的遗传基础。结果单变量MR分析显示,GERD与AP(IVW:OR=1.443,95%CI:1.258~1.656,P<0.001)和CP(IVW:OR=1.538,95%CI:1.244~1.901,P<0.001)风险之间呈正向因果关联。而AP(IVW:OR=0.979,95%CI:0.934~1.025,P=0.358)和CP(IVW:OR=1.026,95%CI:0.985~1.069,P=0.220)与GERD风险之间不存在因果关联。MR-Egger、加权中位数法、简单模式法和加权模式法的结果在方向和效应量上与IVW法保持一致。多变量MR分析调整了潜在混杂因素(吸烟、吸烟频率、饮酒、饮酒频率和胆结石)后,结果与单变量MR基本一致。共定位分析显示,GERD与AP、CP的假设4的后验概率分别为1.1%和4.5%,两者不存在共同的遗传基础。结论GERD可增加胰腺炎的发生风险,建议通过积极控制GERD来降低胰腺炎的发生率。 展开更多
关键词 胃食管反流病 胰腺炎 孟德尔随机化 共定位 危险因素
暂未订购
中国农村能源碳排放演进趋势及关键影响因素分析
11
作者 李贝 卢奕亨 +1 位作者 夏锐 郑家喜 《环境科学》 北大核心 2026年第1期36-46,共11页
明晰中国农村能源碳排放演进趋势及关键影响因素对推动农业农村绿色发展、如期实现“双碳”目标具有重要意义.在厘清中国及30个省份农村能源碳排放现状特征的基础上,综合运用核密度估计法与随机森林模型,重点分析了农村能源碳排放的演... 明晰中国农村能源碳排放演进趋势及关键影响因素对推动农业农村绿色发展、如期实现“双碳”目标具有重要意义.在厘清中国及30个省份农村能源碳排放现状特征的基础上,综合运用核密度估计法与随机森林模型,重点分析了农村能源碳排放的演进趋势及关键影响因素.结果表明:(1)2005~2022年中国农村能源碳排放总量整体处于上升趋势,其演变特征可大致划分为“波动上升、相对平稳、持续上升”这3个阶段,碳排放强度在考察期内累计增幅超过160%.分省域来看,农村能源碳排放总量以广东居首,上海排在最后一位;强度以天津居首,广西排在最后一位.(2)考察期内,无论是全国还是南、北方地区的农村能源碳排放强度均明显提高,低值区域省份分布明显减少,全国及北方地区的农村能源碳排放强度在考察期末仍呈现出一定的两极分化特征.(3)农村能源碳排放受经济、社会和政府这3个层面因素的共同影响.其中,经济层面的因素中,农业产业结构对农村能源碳排放呈倒“U”型的影响效应;社会层面的因素中,农村人口老龄化、农业机械化程度与农村人力资本水平的提升均会导致农村能源碳排放增加,而城镇化水平提升则能发挥抑制作用;政府层面的因素中,财政支农水平的提升有助于实现农村能源碳减排.研究结果可为农村地区减排固碳优化路径的构建提供科学参考. 展开更多
关键词 农业碳排放 农村能源碳排放 演进趋势 影响因素 随机森林
原文传递
炎症细胞因子与冻结肩:来自FinnGen GWAS数据库欧洲人群的大样本分析
12
作者 颜威 孔令军 +3 位作者 何天翔 朱清广 奚小冰 房敏 《中国组织工程研究》 北大核心 2026年第22期5867-5875,共9页
背景:冻结肩是骨伤科常见疾病,但无特异性确诊的临床指标,炎症细胞因子与冻结肩有相当大的关联,但具体因果关系尚未明确。此研究采用全基因组关联研究的汇总统计数据进行孟德尔随机化分析,全基因组关联研究数据基于大样本遗传变异信息,... 背景:冻结肩是骨伤科常见疾病,但无特异性确诊的临床指标,炎症细胞因子与冻结肩有相当大的关联,但具体因果关系尚未明确。此研究采用全基因组关联研究的汇总统计数据进行孟德尔随机化分析,全基因组关联研究数据基于大样本遗传变异信息,可减少环境混杂因素干扰,更可靠地推断炎症细胞因子与冻结肩的因果关系,弥补传统观察性研究无法确定因果关联的局限。目的:运用双向双样本孟德尔随机化方法,探讨炎症细胞因子与冻结肩发病之间的因果关系。方法:利用FinnGen数据库中全基因组关联研究的汇总统计数据,对41种炎性细胞因子和冻结肩的因果关系进行分析。FinnGen数据库由芬兰国立卫生与福利研究院(THL)、赫尔辛基大学等多家芬兰科研机构联合发起,包括2942例病例和167641例欧洲血统对照,整合数十万至百万级人群的基因组、临床表型和生化指标数据,支持疾病遗传关联研究。该研究基于公开可用的汇总统计数据库,无需伦理审批。采用逆方差加权法、加权中位数法、加权模型法、简单模型法、MR-Egger回归和敏感性分析(包括MR-Egger、MR-PRESSO、Cochran’s Q检验)进行双向孟德尔随机化分析。结果与结论:单核细胞趋化蛋白3在正反两个方向上均具有显著的因果效应。在正向分析中,单核细胞趋化蛋白3与冻结肩风险呈正相关(OR=1.176,95%CI:1.034-1.338,P=0.014);在反向分析中,冻结肩与单核细胞趋化蛋白3水平呈负相关(OR=0.782,95%CI:0.625-0.979,P=0.032)。此外,发现肿瘤坏死因子β与冻结肩风险之间有显著关联(OR=1.126,95%CI:1.002-1.264,P=0.046);在反向分析中,基质细胞衍生因子1α与冻结肩风险之间也有显著关联(OR=1.1,95%CI:1.011-1.196,P=0.028),表明肿瘤坏死因子β、基质细胞衍生因子1α与冻结肩存在可靠的相关性。此双向孟德尔随机化研究揭示了单核细胞趋化蛋白3与冻结肩之间的复杂相互作用,提示单核细胞趋化蛋白3可能作为一个潜在的治疗靶点。此外,研究还表明肿瘤坏死因子β与冻结肩风险相关,可能是冻结肩潜在的风险因子;而冻结肩亦与基质细胞衍生因子1α水平升高相关,基质细胞衍生因子1α具备成为冻结肩诊断标志物的潜力。但还需进一步研究以阐明这些因果关系背后的生物学机制。此外国际数据库的分析为中国研究提供了候选分子和因果推断范式,但需结合本土数据实现精准转化。 展开更多
关键词 冻结肩 炎症细胞因子 单核细胞趋化蛋白3 基质细胞衍生因子1Α 孟德尔随机化分析
暂未订购
基于随机森林算法的2型糖尿病共病病人焦虑和抑郁影响因素研究
13
作者 邵梦瑶 潘欣欣 +1 位作者 陆敏 王艳梅 《护理研究》 北大核心 2026年第2期185-192,共8页
目的:基于随机森林算法探讨2型糖尿病(T2DM)共病病人的焦虑及抑郁现状,并分析其影响因素。方法:于2023年11月—2024年4月,采用便利抽样法选取上海市浦东新区某三级医院及3所社区医院的1652例T2DM共病病人作为研究对象。采用一般资料调... 目的:基于随机森林算法探讨2型糖尿病(T2DM)共病病人的焦虑及抑郁现状,并分析其影响因素。方法:于2023年11月—2024年4月,采用便利抽样法选取上海市浦东新区某三级医院及3所社区医院的1652例T2DM共病病人作为研究对象。采用一般资料调查表、广泛性焦虑障碍量表(GAD-7)、病人健康问卷抑郁症状群量表(PHQ-9)进行调查。采用随机森林算法筛选重要影响因素,采用Logistic回归分析探究T2DM共病病人发生焦虑、抑郁的影响因素。结果:1652例病人中,382例(23.1%)发生焦虑,565例(34.2%)发生抑郁。焦虑的影响因素为6个,重要性由高到低依次为婚姻状况、工作状态、年龄、合并症数量、糖尿病家族史、饮酒史。抑郁的影响因素为9个,重要性由高到低依次为年龄、糖尿病家族史、工作状态、受教育程度、婚姻状况、家庭月均收入、合并症数量、病程、体质指数(BMI)。Logistic回归分析结果显示,年龄、婚姻状况、工作状态、糖尿病家族史、合并症数量是T2DM共病病人发生焦虑及抑郁的共同影响因素(P<0.05);饮酒史是其发生焦虑的影响因素(P<0.05);BMI、受教育程度、家庭月均收入、病程是其发生抑郁的影响因素(P<0.05)。结论:T2DM共病病人焦虑及抑郁发生率均较高,其影响因素较多,医护人员应及早识别并实施针对性的干预措施,提高病人心理健康水平,改善病人结局。 展开更多
关键词 2型糖尿病 糖尿病共病 焦虑 抑郁 随机森林模型 LOGISTIC回归 影响因素
暂未订购
烧伤与多组学生物标志物:41种炎症因子和35种血液尿液指标的因果关系
14
作者 高敏怡 刘平洪 林海雄 《中国组织工程研究》 北大核心 2026年第23期6062-6070,共9页
背景:传统观察性研究难以揭露烧伤与生物标志物间的潜在因果关系,孟德尔随机化凭借遗传变异作为工具变量模拟随机对照试验的优势,成为解析复杂疾病因果关联的重要工具。目的:基于孟德尔随机化方法探讨烧伤与41种炎症因子和35种血液和尿... 背景:传统观察性研究难以揭露烧伤与生物标志物间的潜在因果关系,孟德尔随机化凭借遗传变异作为工具变量模拟随机对照试验的优势,成为解析复杂疾病因果关联的重要工具。目的:基于孟德尔随机化方法探讨烧伤与41种炎症因子和35种血液和尿液标志物的关系。方法:①烧伤的完整全基因组关联研究数据在IEU open gwas project数据库(由英国The University of Bristol构建)中获取,该数据包括了218131例样本,16380465个单核苷酸多态性;②41种炎症因子数据来源于芬兰青年心血管风险研究数据库(由图尔库大学应用和预防心血管医学研究中心构建)一项8293人的研究数据;③35种血液和尿液生物标志物数据来源于英国生物样本库(由英国政府、惠康基金会和英国医学研究理事会共同发起的大型生物医学数据库项目)(n=363228人)。以单核苷酸多态性作为工具变量,利用逆方差加权、MR Egger、加权中位数和加权模式的方法进行分析。采用Cochrane’s Q检验来识别结果的异质性,MR Egger截距检验和MR-PRESSO检验及“留一法”检验等评估暴露-结局关联的可靠性。结果与结论:烧伤降低了白细胞介素9(OR=0.97;95%CI,0.949 to 0.997;P=0.030)和睾酮(OR=0.997;95%CI,0.995 to 0.999;P=0.025)水平,且不存在异质性和水平多效性,证明了结果的稳健性。研究通过孟德尔随机化分析表明,烧伤后白细胞介素9和睾酮水平降低,提示提高白细胞介素9和睾酮水平可能有助于烧伤后组织修复和改善蛋白质分解速率。 展开更多
关键词 烧伤 炎症因子 生物标志物 孟德尔随机化 白细胞介素9 睾酮
暂未订购
新疆农村家庭健康贫困脆弱性现状及其影响因素研究
15
作者 任艳霞 芮东升 +4 位作者 付志聪 李延萍 贡浩轩 刘思佟 毛璐 《农垦医学》 2026年第1期57-62,共6页
目的:了解新疆农村家庭健康贫困脆弱性现状并研究其影响因素,从而为优化后脱贫时代的健康扶贫政策提供理论支持与实践依据。方法:文章基于新疆5个县2993户农村家庭的实地调查数据,运用VEP理论对其健康贫困脆弱性进行测量,使用Tobit回归... 目的:了解新疆农村家庭健康贫困脆弱性现状并研究其影响因素,从而为优化后脱贫时代的健康扶贫政策提供理论支持与实践依据。方法:文章基于新疆5个县2993户农村家庭的实地调查数据,运用VEP理论对其健康贫困脆弱性进行测量,使用Tobit回归模型分析其影响因素,并运用随机森林模型对变量重要性进行排序。结果:新疆农村家庭健康贫困脆弱性均值为0.128。家庭户主婚姻状况、受教育程度、自评健康状况以及家庭劳动力人数、最近的医疗卫生机构类别和家庭成员医疗保险参保比例对农村家庭健康贫困脆弱性具有负向影响(P<0.05);而户主年龄、家庭规模、风险性卫生支出和家庭到医疗机构的时间对其具有正向影响(P<0.05)。其中,风险性卫生支出、家庭规模、家庭劳动力人数、户主受教育程度这4个变量对其影响程度较大,%IncMSE分别为89.62、69.83、54.05、44.79。结论:政府要完善医保政策,重视大病保险发挥的重要作用;重视教育在保护健康中发挥的作用;完善医疗卫生机构的基础设施,提高医疗技术水平;加大对弱势群体的帮扶力度。 展开更多
关键词 健康贫困脆弱性 影响因素 VEP理论 TOBIT回归 随机森林
暂未订购
WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS WITH INITIAL STRESS 被引量:5
16
作者 Yize Wang Fengming Li +2 位作者 Kikuo Kishimoto Yuesheng Wang Wenhu Huang 《Acta Mechanica Solida Sinica》 SCIE EI 2008年第6期529-535,共7页
The elastic wave localization in disordered periodic piezoelectric rods with initial stress is studied using the transfer matrix and Lyapunov exponent method. The electric field is approximated as quasi-static. The ef... The elastic wave localization in disordered periodic piezoelectric rods with initial stress is studied using the transfer matrix and Lyapunov exponent method. The electric field is approximated as quasi-static. The effects of the initial stress on the band gap characteristics are investigated. The numerical calculations of localization factors and localization lengths are performed. It can be observed from the results that the band structures can be tuned by exerting the suitable initial stress. For different values of the piezoelectric rod length and the elastic constant, the band structures and the localization phenomena are very different. Larger disorder degree can lead to more obvious localization phenomenon. 展开更多
关键词 piezoelectric phononic crystal initial stress random disorder localization factor localization length
在线阅读 下载PDF
Probabilistic stability analyses of undrained slopes by 3D random fields and finite element methods 被引量:23
17
作者 Yong Liu Wengang Zhang +3 位作者 Lei Zhang Zhiren Zhu Jun Hu Hong Wei 《Geoscience Frontiers》 SCIE CAS CSCD 2018年第6期1657-1664,共8页
A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties.... A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties. Although 3 D random finite element analysis can well reflect the spatial variability of soil properties, it is often time-consuming for probabilistic stability analysis. For this reason, we also examined the least advantageous(or most pessimistic) cross-section of the studied slope. The concept of"most pessimistic" refers to the minimal cross-sectional average of undrained shear strength. The selection of the most pessimistic section is achievable by simulating the undrained shear strength as a 3 D random field. Random finite element analysis results suggest that two-dimensional(2 D) plane strain analysis based the most pessimistic cross-section generally provides a more conservative result than the corresponding full 3 D analysis. The level of conservativeness is around 15% on average. This result may have engineering implications for slope design where computationally tractable 2 D analyses based on the procedure proposed in this study could ensure conservative results. 展开更多
关键词 random field SLOPE stability factor of safety Statistical analysis FINITE-ELEMENT modelling Monte-Carlo simulations
在线阅读 下载PDF
Analysis of PM2.5 concentrations in Heilongjiang Province associated with forest cover and other factors 被引量:6
18
作者 Yu Zheng San Li +2 位作者 Chuanshan Zou Xiaojian Ma Guocai Zhang 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第1期269-276,共8页
Atmospheric particulate matter(PM2.5) seriously influences air quality. It is considered one of the main environmental triggers for lung and heart diseases. Air pollutants can be adsorbed by forest. In this study we i... Atmospheric particulate matter(PM2.5) seriously influences air quality. It is considered one of the main environmental triggers for lung and heart diseases. Air pollutants can be adsorbed by forest. In this study we investigated the effect of forest cover on urban PM2.5 concentrations in 12 cities in Heilongjiang Province,China. The forest cover in each city was constant throughout the study period. The average daily concentration of PM2.5 in 12 cities was below 75 lg/m^3 during the non-heating period but exceeded this level during heating period. Furthermore, there were more moderate pollution days in six cities. This indicated that forests had the ability to reduce the concentration of PM2.5 but the main cause of air pollution was excessive human interference and artificial heating in winter. We classified the 12 cities according to the average PM2.5 concentrations. The relationship between PM2.5 concentrations and forest cover was obtained by integrating forest cover, land area,heated areas and number of vehicles in cities. Finally,considering the complexity of PM2.5 formation and based on the theory of random forestry, we selected six cities and analyzed their meteorological and air pollutant data. The main factors affecting PM2.5 concentrations were PM10,NO_2, CO and SO_2 in air pollutants while meteorological factors were secondary. 展开更多
关键词 FOREST COVER Heilongjiang PROVINCE Influencing factor PM2.5 CONCENTRATIONS random FOREST
在线阅读 下载PDF
Influencing factors and growth state classification of a natural Metasequoia population 被引量:3
19
作者 Mu Liu Zhongke Feng +1 位作者 Chenghui Ma Liyan Yang 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第1期337-345,共9页
By analyzing the importance of influencing factors and conducting a comparative study of the effects of different sorting algorithms, a new method is proposed that is suitable for classifying the growth state of a nat... By analyzing the importance of influencing factors and conducting a comparative study of the effects of different sorting algorithms, a new method is proposed that is suitable for classifying the growth state of a natural Metasequoia glyptostroboides Hu and W.C. Cheng population. We studied 2817 M. glyptostroboides trees over 100 years old and analyzed their growth state by measuring 15 factors from stumpage, site condition, and environmental data. The dimensionality of all factors were reduced using the random forest algorithm, and we classified the remaining factors using the following algorithms: random forest, back-propagation(BP) neural networks, and support vector machine(SVM). The applicability of each sorting algorithm was analyzed. When all the d factors are used for classification and modeling, the model's overall accuracy,kappa coefficient and test accuracy were 85.5%, 0.739 and 85.8%, respectively. By reducing the dimensionality of the factors using the random forest algorithm, 11 factors most strongly influenced the classifications of the growth state of the Metasequoia population: diameter at breast height,height, crown width, age from stumpage data; longitude,latitude, elevation, slope aspect, gradient and slope position from the site condition data; and the edge of the field from the environmental data. For classifying the Metasequoia population, the random forest algorithm has the highest overall accuracy at 87.2%, which is 3.4 and 2.3% higher than the BP neural networks and SVM algorithms,respectively. The SVM algorithm is superior to the random forest algorithm with respect to classifying the state of mortality. The combination of the random forest and SVM algorithms and their combined information can be used to classify and predict the growth state of this natural M.glyptostroboides population to provide a scientific basis for its effective protection. 展开更多
关键词 METASEQUOIA glyptostroboides GROWTH state random FOREST Support VECTOR machine(SVM) Influencing factor
在线阅读 下载PDF
变化环境下西江干流水文情势演变及其驱动因素 被引量:4
20
作者 李继清 刘佳利 +1 位作者 邓世浪 吴亮 《水资源保护》 北大核心 2025年第1期9-18,共10页
为掌握变化环境下西江干流水文情势演变特征及主要驱动因素,通过识别径流序列突变点将径流序列划分为天然时期和变化时期,采用基于水文改变指标的变化范围法定量探究各水文指标改变度,借助水文变异程度和水文情势变化法(DHRAM)评估整体... 为掌握变化环境下西江干流水文情势演变特征及主要驱动因素,通过识别径流序列突变点将径流序列划分为天然时期和变化时期,采用基于水文改变指标的变化范围法定量探究各水文指标改变度,借助水文变异程度和水文情势变化法(DHRAM)评估整体水文情势改变度,利用主成分分析法筛选最相关生态指标捕捉关键水文变量,并基于随机森林模型,结合残差分析法定量评估气候变化与人类活动对流域水文情势的影响。结果表明:西江干流4座水文站32个水文指标以中、低度改变为主,天峨、迁江、武宣、梧州站水文变异程度分别为64.70%、61.34%、51.70%、51.89%,基于DHRAM得到各站水文情势改变等级分别为3、3、2、3,综合判定4站整体水文情势改变度均为中度;中上游天峨、迁江站改变度比中下游武宣、梧州站高,应重点关注中上游生态保护;气候变化与人类活动均是西江干流水文情势变化的重要驱动因素,气候变化对天峨、迁江、武宣、梧州站水文情势变化的贡献率分别为25.65%、60.07%、50.29%、55.22%,气候变化对于西江流域中下游地区水文情势的影响大于上游地区。 展开更多
关键词 水文情势变化 IHA-RVA 驱动因素 随机森林模型 西江干流
在线阅读 下载PDF
上一页 1 2 72 下一页 到第
使用帮助 返回顶部