The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect...The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.展开更多
The synergy and complementary strengths between Macao and Hengqin can create an important channel for Chinese companies to internationalize.CHINESE enterprises have placed much emphasis on going global in recent years...The synergy and complementary strengths between Macao and Hengqin can create an important channel for Chinese companies to internationalize.CHINESE enterprises have placed much emphasis on going global in recent years,from traditional manufacturing giants to emerging tech unicorns,and from traditional sectors to emerging industries like electric vehicles,lithium batteries,and photovoltaic products.The enthusiasm to internationalize reached unprecedented levels in 2024.展开更多
Objectives This study aimed to clarify the relationship between the content of proxy decision-making made by families of patients with malignant brain tumors regarding treatment policies and daily care and the cues le...Objectives This study aimed to clarify the relationship between the content of proxy decision-making made by families of patients with malignant brain tumors regarding treatment policies and daily care and the cues leading to those decisions.Methods Semi-structured personal interviews were used to collect data.Seven family members of patients with malignant brain tumors were selected to participate in the study by purposive sampling method from June to August 2022 in the Patient Family Association of Japan.Responses were content analyzed to explore the relationship between the content of decisions regarding“treatment policies”and“daily care”and the cues influencing those decisions.Semi-structured interviews were analyzed by using thematic analysis.Results The contents of proxy decisions regarding“treatment policies”included implementation,interruption,and termination of initial treatments,free medical treatments,use of respirators,and end-of-life sedation and included six cues:treatment policies suggested by the primary physician,information and knowledge about the disease and treatment obtained by the family from limited resources,perceived life threat from symptom worsening,words and reactions from the patient regarding treatment,patient’s personality and way of life inferred from their treatment preferences,family’s thoughts and values hoping for better treatment for the patient.Decisions for“daily care”included meal content and methods,excretion,mobility,maintaining cleanliness,rehabilitation,continuation or resignation from work,treatment settings(outpatient or inpatient),and ways to spend time outside and included seven cues:words and thoughts from the patient about their way of life,patient’s reactions and life history inferred from their preferred way of living,things the patient can do to maintain daily life and roles,awareness of the increasing inability to do things in daily life,family’s underlying thoughts and values about how to spend the remaining time,approval from family members regarding the care setting,advice from medical professionals on living at home.Conclusions For“treatment policies,”guidelines from medical professionals were a key cue,while for“daily care,”the small signs from the patients in their daily lives served as cues for proxy decision-making.This may be due to the lack of information available to families and the limited time available for discussion with the patient.Families of patients with malignant brain tumors repeatedly use multiple cues to make proxy decision-making under high uncertainty.Therefore,nurses supporting proxy decision-making should assess the family’s situation and provide cues that facilitate informed and confident decisions.展开更多
With the rapid development of web3.0 applications,the volume of data sharing is increasing,the inefficiency of big data file sharing and the problem of data privacy leakage are becoming more and more prominent,and the...With the rapid development of web3.0 applications,the volume of data sharing is increasing,the inefficiency of big data file sharing and the problem of data privacy leakage are becoming more and more prominent,and the existing data sharing schemes have been difficult to meet the growing demand for data sharing,this paper aims at exploring a secure,efficient and privacy-protecting data sharing scheme under web3.0 applications.Specifically,this paper adopts interplanetary file system(IPFS)technology to realize the storage of large data files to solve the problem of blockchain storage capacity limitation,and utilizes ciphertext policy attribute-based encryption(CP-ABE)and proxy re-encryption(PRE)technology to realize secure multi-party sharing and finegrained access control of data.This paper provides the detailed algorithm design and implementation of data sharing phases and processes,and analyzes the algorithms from the perspectives of security,privacy protection,and performance.展开更多
Conditional proxy re-encryption(CPRE)is an effective cryptographic primitive language that enhances the access control mechanism and makes the delegation of decryption permissions more granular,but most of the attribu...Conditional proxy re-encryption(CPRE)is an effective cryptographic primitive language that enhances the access control mechanism and makes the delegation of decryption permissions more granular,but most of the attribute-based conditional proxy re-encryption(AB-CPRE)schemes proposed so far do not take into account the importance of user attributes.A weighted attribute-based conditional proxy re-encryption(WAB-CPRE)scheme is thus designed to provide more precise decryption rights delegation.By introducing the concept of weight attributes,the quantity of system attributes managed by the server is reduced greatly.At the same time,a weighted tree structure is constructed to simplify the expression of access structure effectively.With conditional proxy re-encryption,large amounts of data and complex computations are outsourced to cloud servers,so the data owner(DO)can revoke the user’s decryption rights directly with minimal costs.The scheme proposed achieves security against chosen plaintext attacks(CPA).Experimental simulation results demonstrated that the decryption time is within 6–9 ms,and it has a significant reduction in communication and computation cost on the user side with better functionality compared to other related schemes,which enables users to access cloud data on devices with limited resources.展开更多
Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civili...Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civilizations,where ideas and cultures have exchanged and thrived.Driven by the vision of a community with a shared future for mankind in recent years,Chengdu scholars and media have opened their arms to the world,engaging in multilingual storytelling.These efforts share the warmth and goodwill of a city consistently ranked one of the happiest in China.Through consistent efforts,new insights have emerged—ideas and aspirations intended to be shared with readers both at home and abroad.展开更多
Salinity is a fundamental variable of watermass chemistry,often varying strongly in coastal,estuarine,lagoonal,restricted-marine basinal,and non-freshwater lacustrine systems(Figure 1).Salinity variation commonly cont...Salinity is a fundamental variable of watermass chemistry,often varying strongly in coastal,estuarine,lagoonal,restricted-marine basinal,and non-freshwater lacustrine systems(Figure 1).Salinity variation commonly controls other watermass properties(e.g.,redox,temperature,p H,and chemical composition)as well as nutrient levels(and thus bioproductivity).展开更多
As industrialization and informatization in China deeply integrate and the Internet of Things rapidly develops,industrial control systems are facing increasingly severe information security challenges.The industrial c...As industrialization and informatization in China deeply integrate and the Internet of Things rapidly develops,industrial control systems are facing increasingly severe information security challenges.The industrial control system of the gas extraction plant is characterized by numerous points and centralized operations,with a strong reliance on the system and stringent real-time requirements.展开更多
文摘The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.
文摘The synergy and complementary strengths between Macao and Hengqin can create an important channel for Chinese companies to internationalize.CHINESE enterprises have placed much emphasis on going global in recent years,from traditional manufacturing giants to emerging tech unicorns,and from traditional sectors to emerging industries like electric vehicles,lithium batteries,and photovoltaic products.The enthusiasm to internationalize reached unprecedented levels in 2024.
文摘Objectives This study aimed to clarify the relationship between the content of proxy decision-making made by families of patients with malignant brain tumors regarding treatment policies and daily care and the cues leading to those decisions.Methods Semi-structured personal interviews were used to collect data.Seven family members of patients with malignant brain tumors were selected to participate in the study by purposive sampling method from June to August 2022 in the Patient Family Association of Japan.Responses were content analyzed to explore the relationship between the content of decisions regarding“treatment policies”and“daily care”and the cues influencing those decisions.Semi-structured interviews were analyzed by using thematic analysis.Results The contents of proxy decisions regarding“treatment policies”included implementation,interruption,and termination of initial treatments,free medical treatments,use of respirators,and end-of-life sedation and included six cues:treatment policies suggested by the primary physician,information and knowledge about the disease and treatment obtained by the family from limited resources,perceived life threat from symptom worsening,words and reactions from the patient regarding treatment,patient’s personality and way of life inferred from their treatment preferences,family’s thoughts and values hoping for better treatment for the patient.Decisions for“daily care”included meal content and methods,excretion,mobility,maintaining cleanliness,rehabilitation,continuation or resignation from work,treatment settings(outpatient or inpatient),and ways to spend time outside and included seven cues:words and thoughts from the patient about their way of life,patient’s reactions and life history inferred from their preferred way of living,things the patient can do to maintain daily life and roles,awareness of the increasing inability to do things in daily life,family’s underlying thoughts and values about how to spend the remaining time,approval from family members regarding the care setting,advice from medical professionals on living at home.Conclusions For“treatment policies,”guidelines from medical professionals were a key cue,while for“daily care,”the small signs from the patients in their daily lives served as cues for proxy decision-making.This may be due to the lack of information available to families and the limited time available for discussion with the patient.Families of patients with malignant brain tumors repeatedly use multiple cues to make proxy decision-making under high uncertainty.Therefore,nurses supporting proxy decision-making should assess the family’s situation and provide cues that facilitate informed and confident decisions.
基金supported by the National Natural Science Foundation of China(Grant No.U24B20146)the National Key Research and Development Plan in China(Grant No.2020YFB1005500)Beijing Natural Science Foundation Project(No.M21034).
文摘With the rapid development of web3.0 applications,the volume of data sharing is increasing,the inefficiency of big data file sharing and the problem of data privacy leakage are becoming more and more prominent,and the existing data sharing schemes have been difficult to meet the growing demand for data sharing,this paper aims at exploring a secure,efficient and privacy-protecting data sharing scheme under web3.0 applications.Specifically,this paper adopts interplanetary file system(IPFS)technology to realize the storage of large data files to solve the problem of blockchain storage capacity limitation,and utilizes ciphertext policy attribute-based encryption(CP-ABE)and proxy re-encryption(PRE)technology to realize secure multi-party sharing and finegrained access control of data.This paper provides the detailed algorithm design and implementation of data sharing phases and processes,and analyzes the algorithms from the perspectives of security,privacy protection,and performance.
基金Programs for Science and Technology Development of Henan Province,grant number 242102210152The Fundamental Research Funds for the Universities of Henan Province,grant number NSFRF240620+1 种基金Key Scientific Research Project of Henan Higher Education Institutions,grant number 24A520015Henan Key Laboratory of Network Cryptography Technology,grant number LNCT2022-A11.
文摘Conditional proxy re-encryption(CPRE)is an effective cryptographic primitive language that enhances the access control mechanism and makes the delegation of decryption permissions more granular,but most of the attribute-based conditional proxy re-encryption(AB-CPRE)schemes proposed so far do not take into account the importance of user attributes.A weighted attribute-based conditional proxy re-encryption(WAB-CPRE)scheme is thus designed to provide more precise decryption rights delegation.By introducing the concept of weight attributes,the quantity of system attributes managed by the server is reduced greatly.At the same time,a weighted tree structure is constructed to simplify the expression of access structure effectively.With conditional proxy re-encryption,large amounts of data and complex computations are outsourced to cloud servers,so the data owner(DO)can revoke the user’s decryption rights directly with minimal costs.The scheme proposed achieves security against chosen plaintext attacks(CPA).Experimental simulation results demonstrated that the decryption time is within 6–9 ms,and it has a significant reduction in communication and computation cost on the user side with better functionality compared to other related schemes,which enables users to access cloud data on devices with limited resources.
文摘Chengdu,a city rich in history and culture,is a beacon of China’s storied past embracing a distinct postmodern vibe.As an important hub along the ancient Silk Road,it has long been a meeting point for di!erent civilizations,where ideas and cultures have exchanged and thrived.Driven by the vision of a community with a shared future for mankind in recent years,Chengdu scholars and media have opened their arms to the world,engaging in multilingual storytelling.These efforts share the warmth and goodwill of a city consistently ranked one of the happiest in China.Through consistent efforts,new insights have emerged—ideas and aspirations intended to be shared with readers both at home and abroad.
文摘Salinity is a fundamental variable of watermass chemistry,often varying strongly in coastal,estuarine,lagoonal,restricted-marine basinal,and non-freshwater lacustrine systems(Figure 1).Salinity variation commonly controls other watermass properties(e.g.,redox,temperature,p H,and chemical composition)as well as nutrient levels(and thus bioproductivity).
文摘As industrialization and informatization in China deeply integrate and the Internet of Things rapidly develops,industrial control systems are facing increasingly severe information security challenges.The industrial control system of the gas extraction plant is characterized by numerous points and centralized operations,with a strong reliance on the system and stringent real-time requirements.
