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Prophylactic effects of nirmatrelvir/ritonavir on reducing complications of cardiac surgery,reinfection,and post-acute sequelae of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in patients with previous SARS-CoV-2 infection:a randomized clinical trial(PEP Trial)
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作者 Xin Yuan Lihua Zhang +17 位作者 Jingkuo Li Lubi Lei Kai Chen Qing Chu Wei Feng Xiaoqi Wang Zhaoyun Cheng Yan Yang Yang Wang Hansong Sun Yunhu Song Sheng Liu Xianqiang Wang Shuiyun Wang Liqing Wang Xin Wang Fei Xu Shengshou Hu 《Science Bulletin》 2025年第12期1932-1936,共5页
Patients undergoing cardiac surgery are significantly highly at risk of adverse outcomes due to comorbidities and aging[1].A previous study indicated that perioperative severe acute respiratory syndrome coronavirus 2(... Patients undergoing cardiac surgery are significantly highly at risk of adverse outcomes due to comorbidities and aging[1].A previous study indicated that perioperative severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection substantially increased postoperative morbidity and mortality[2].Despite the widespread vaccination efforts,cardiac surgery patients with a history of coronavirus disease 2019(COVID-19)remain vulnerable to reinfection due to the persistence of the virus in the body,even after respiratory viral detection test results return negative[3]. 展开更多
关键词 nirmatrelvir ritonavir REINFECTION post acute sequelae SARS CoV cardiac surgery severe acute respiratory syndrome coronavirus prophylactic effects severe acute respiratory syndrome
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