Business Process Exeention Language （BPEL） is being used in various applications as the standard of workflow. As the requirerments increase to describe application processes in BPEL, BPEL documentt is getting more C...Business Process Exeention Language （BPEL） is being used in various applications as the standard of workflow. As the requirerments increase to describe application processes in BPEL, BPEL documentt is getting more Complplicated. Therefore it is difficult to describe applications in BPEL with high reliability. In order to write highly reliable BPEL document, it is necessary to check if the document is working correctly in accordance with user＇s intention. But it is difficult to carry out the test since BPEL engine doesn＇t provide a profiling function. In this paper, we suggest a BPEL system with a real-time profiling function. The suggested system consists of an integrated development environment and a BPEL nunning environment. BPEL integrated development environment has a BPEL to Java（B2J） engine, which generates and executes a Java workflow program from a BPEL document, and a converter, which converts Java Weaving XML （JWX） documents to Aspect-oriented programs. The new functions are described in JWX, which is Extensive Markup Lan-guage （XML）-based document. Since aspect-oriented programming technique provides the way to modularize main and supplemental requirements, it guarantees the low degree of coupling between BPEL workflow program and new functions by weaving them. Our approach can be extended to add other functions to provide context-aware services.展开更多
The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract(ASE)by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase(MMP),collagenase,elastase,hyaluronid...The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract(ASE)by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase(MMP),collagenase,elastase,hyaluronidase,and tyrosinase in relation to its chemical composition.Ultra Performance Liquid Chromatography-Mass Spectrometry(UPLC-MS)identified 27 metabolites(15 flavonoids,8 phenolic acids and their derivatives,and 4 coumarins).ASE showed strong antioxidant capacity in DPPH(IC_(50)value of 26.05μg/mL)and FRAP(2433μM FeSO_(4)/g extract)assays.The extract inhibited MMP-1 and MMP-9 in a concentration-dependent manner and suppressed collagenase,elastase,hyaluronidase,and tyrosinase activities(IC_(50)=35.038,40.748,61.389,and 30.980μg/mL,respectively).A network pharmacology study was conducted to uncover the mechanisms responsible for skin anti-aging effects,and molecular docking further evaluated interactions of key metabolites with hub targets.Twenty-one bioactive metabolites,selected based on oral bioavailability and drug-likeness,highlighted cinnamic acid,acacetin,luteolin,kaempferol,and apigenin as key compounds.MMP-9,ESR1,PTGS-2,and EGFR were identified as main targets.Docking studies revealed that acacetin and apigenin have stronger binding affinities to MMP-9,PTGS-2,and EGFR than other constituents.These findings suggest that ASE may serve as a natural multi-target skin anti-aging remedy with potential cosmetic applications.展开更多
Head-splitting is a prevalent physiological disorder in cabbage that causes substantial economic losses.However,the genetic factors and molecular mechanisms underlying head-splitting resistance remain largely unexplor...Head-splitting is a prevalent physiological disorder in cabbage that causes substantial economic losses.However,the genetic factors and molecular mechanisms underlying head-splitting resistance remain largely unexplored.This study identified a genomic region(q NLQ3.1) for head-splitting resistance on chromosome C03 through the combination of QTLseq and GPS analysis in an F_(2) population derived from hybridizing two cabbage inbred lines,‘Dazhengfu'(ZF,susceptible) and ‘103'(resistant).Traditional genetic linkage analysis narrowed q NLQ3.1 to a 74.6 kb region.Furthermore,comparative analysis of the two parental lines using transcriptomic and metabolic profiling demonstrated the crucial role of hormones in regulating head-splitting resistance.Bol028000,encoding a homologue of Arabidopsis Cytokinin Response Factor 3(CRF3),emerged as a promising candidate for head-splitting resistance and was subsequently validated through Sanger sequencing and quantitative RT-PCR(qRT-PCR).Subcellular localisation analysis revealed that Bol028000 was mainly expressed in the nucleus.Additionally,one kompetitive allele-specific PCR(KASP) marker from Bol028000 was developed and utilized to screen 42 inbred lines.These findings enhance the theoretical understanding of head-splitting resistance and provide valuable insights for the molecular breeding of head-splitting resistant cabbages.展开更多
Global warming underscores the urgent need to enhance carbon sinks to mitigate climate change,yet the role of coastal shellfish aquaculture area as either carbon sinks or sources remains unclear.In this study,we condu...Global warming underscores the urgent need to enhance carbon sinks to mitigate climate change,yet the role of coastal shellfish aquaculture area as either carbon sinks or sources remains unclear.In this study,we conducted high-resolution profiling observations of CO_(2)dynamics and net community production(NCP)in a mussel farm located in the Changjiang(Yangtze)River estuary(CRE)during early autumn.Results indicate that the partial pressure of CO_(2)(pCO_(2))in the water column was consistently higher than the atmospheric level,averaging 74.75±2.44 Pa,signaling that the mussel farm acted as a CO_(2)source.The average air-water CO_(2)exchange flux(FCO_(2))averaged-1.91±1.16 mmol/(m^(2)·h),and NCP in the water column(NCPCOL)averaged-6.66±12.81 mmol/(m^(2)·h),revealing a heterotrophic condition.A significant inverse correlation was found between NCPCOLand sea surface pCO_(2)with a lag time of approximately 3.31 h,highlighting the influence of biological activity in modulating CO_(2)dynamics.Physical processes such as freshwater inputs,vertical mixing,and wind patterns,also played a crucial role in shaping pCO_(2)variations.The study emphasizes the complexity of CO_(2)dynamics in costal aquaculture areas and the need for long-term,high-resolution monitoring to better understand their contribution to climate change mitigation.The high-resolution profiling system provided novel insights into the dynamics of NCP and CO_(2)fluxes,showing its potential as an advanced tool for studying aquaculture systems.Future research should focus on expanding the geographic and temporal scope of studies,combining observational and modeling approaches to better predict the responses of aquaculture systems to environmental changes.展开更多
There is a need to obtain the hydrologic data including ocean current, wave, temperature and so on in the South China Sea. A new profiling instrument which does not suffer from the damage due to nature forces or incid...There is a need to obtain the hydrologic data including ocean current, wave, temperature and so on in the South China Sea. A new profiling instrument which does not suffer from the damage due to nature forces or incidents caused by passing ships, is under development to acquire data from this area. This device is based on a taut single point mid-water mooring system. It incorporates a small, instrumented vertically profiling float attached via an electromechanical cable to a winch integral with the main subsurface flotation. On a pre-set schedule, the instrument float with sensors is winched up to the surface if there is no ship passing by, which is defined by an on-board miniature sonar. And it can be. inunediately winched down to a certain depth if the sonar sensor finds something is coming. Since, because of logistics, the area can only be visited once for a long time and a minimum of 10 times per day profiles are desired, energy demands are severe. To respond to these concerns, the system has been designed to conserve a substantial portion of the potential energy lost during the ascent phase of each profile and subsequently use this energy to pull the instrument down. Compared with the previous single-point layered measuring mode, it is advanced and economical. At last the paper introduces the test in the South China Sea.展开更多
A multi-beam chirp sonar based on IP connections and DSP processing nodes was proposed and designed to provide an expandable system with high-speed processing and mass-storage of real-time signals for multi-beam profi...A multi-beam chirp sonar based on IP connections and DSP processing nodes was proposed and designed to provide an expandable system with high-speed processing and mass-storage of real-time signals for multi-beam profiling sonar.The system was designed for seabed petroleum pipeline detection and orientation,and can receive echo signals and process the data in real time,refreshing the display 10 times per second.Every node of the chirp sonar connects with data processing nodes through TCP/IP. Merely by adding nodes,the system’s processing ability can be increased proportionately without changing the software.System debugging and experimental testing proved the system to be practical and stable.This design provides a new method for high speed active sonar.展开更多
Over the past two decades,numerous countries have actively participated in the International Argo Program,working toward the global“OneArgo”goal.China's Argo program has deployed over 500 autonomous profiling fl...Over the past two decades,numerous countries have actively participated in the International Argo Program,working toward the global“OneArgo”goal.China's Argo program has deployed over 500 autonomous profiling floats in the Indo-Pacific,with 55 Beidou(BD)floats,equipped with the Beidou satellite communication system,currently operational.During the operation of the BD float network,we found that in addition to the limitation of floats battery,the loss may also be caused by communication loss due to the floats escaping from the Beidou-2's short message coverage.In this study,float trajectories are simulated using velocity fields from an eddy-resolved resolution Estimating the Circulation and Climate of the Ocean,PhaseⅡ(ECCO2)model and a Lagrangian particle tracking model programmed to represent the vertical motions of profiling floats.The simulations can help to explore both the representativeness and the predictability of profiling float displacements.By deploying a large number of synthetic floats in the Lagrangian particle tracking system,we construct probability density functions(PDFs)of the simulated-float trajectory among key oceans,for example,a joint region of East Indian-South China Sea-Northwest Pacific Ocean(5°–40°N,70°–140°E),which is generally similar to the location of the present BD float network.These statistics can help to estimate the chance of floats drifting into shallow seas(such as the East China Sea)and out of the coverage of the Beidou satellite communication.With this knowledge changes to the future China's Argo observing system could be made.展开更多
Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patien...Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patients admitted to the hospital from July 2023 to September 2024 were enrolled.These patients were randomly assigned to a control group and an intervention group,with 52 patients in each group.The control group received routine nursing care,while the intervention group received an“Internet+”nursing intervention based on user profilingin addition to routine care.The intervention period lasted for one month following discharge.Before and one month after the intervention,the Fear of Progression Questionnaire-Short Form(FOP-Q-SF),the Fear of Cancer Recurrence Inventory-Short Form(FCRI-SF),Chinese Posttraumatic Growth Inventory(C-PTGI),and the Functional Assessment of Cancer Therapy-Breast(FACT-B)were applied to assess the effects of interventions.Results:A total of 104 patients were analyzed.After the intervention,FOP-Q-SF and FCRI-SF scores were significantlylower in the intervention group compared to the control group,with statistical significance(t=3.98,P<0.001;t=-7.59,P<0.001),and Cohen’s d of 0.781 and 1.49,respectively.Additionally,CPTGI and FACT-B scores in the intervention group were significantly higher than those in the control group(t=-6.534,P<0.001;t=-4.579,P<0.001),with Cohen’s d of 0.585 and 0.656.Conclusions:An“Internet+”nursing model based on user profilingcould reduce postoperative breast cancer patients fear of disease progression and cancer recurrence,also enhancing posttraumatic growth and overall quality of life.展开更多
In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2...In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.展开更多
Chronic diarrhea remains a frequent and debilitating complication among individuals living with HIV,particularly in the context of advanced immunosuppression.Its multifactorial nature often complicates both diagnosis ...Chronic diarrhea remains a frequent and debilitating complication among individuals living with HIV,particularly in the context of advanced immunosuppression.Its multifactorial nature often complicates both diagnosis and treatment.We present insights from our recent study investigating gut microbial alterations using 16S rRNA sequencing in HIV-positive patients with diarrheal syndrome of unclear etiology.展开更多
Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage,however,there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and...Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage,however,there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and metabolites.This study aimed to investigate how cold storage affects enzyme activities,nutrient composition,tissue microstructures and spoilage metabolites of bigeye tuna.The activities of cathepsins B,H,L increased,while Na^(+)/K^(+)-ATPase and Mg^(2+)-ATPase decreased,α-glucosidase,lipase and lipoxygenase first increased and then decreased during cold storage,suggesting that proteins undergo degradation and ATP metabolism occurs at a faster rate during cold storage.Nutrient composition(moisture and lipid content),total amino acids decreased,suggesting that the nutritional value of bigeye tuna was reduced.Besides,a logistic regression equation has been established as a food analysis tool and assesses the dynamics and correlation of the enzyme of bigeye tuna during cold storage.Based on untargeted metabolomic profiling analysis,a total of 524 metabolites were identified in the bigeye tuna contained several spoilage metabolites involved in lipid metabolism(glycerophosphocholine and choline phosphate),amino acid metabolism(L-histidine,5-deoxy-5′-(methylthio)adenosine,5-methylthioadenosine),carbohydrate metabolism(D-gluconic acid,α-D-fructose 1,6-bisphosphate,D-glyceraldehyde 3-phosphate).The results of tissue microstructures of tuna showed a looser network and visible deterioration of tissue fiber during cold storage.Therefore,metabolomic analysis and tissue microstructures provide insight into the spoilage mechanism investigations on bigeye tuna during cold storage.展开更多
Pigeons and certain other avian species produce a milklike secretion in their crop sacs to nourish offspring,yet the detailed processes involved are not fully elucidated.This study investigated the crop sacs of 225-da...Pigeons and certain other avian species produce a milklike secretion in their crop sacs to nourish offspring,yet the detailed processes involved are not fully elucidated.This study investigated the crop sacs of 225-day-old unpaired non-lactating male pigeons(MN)and males initiating lactation on the first day after incubation(ML).Using RNA sequencing,ribosomeprofiling,andsingle-cell transcriptome sequencing(scRNA-seq),we identified a significant up-regulation of genes associated with ribosome assembly and protein synthesis in ML compared to MN.Results from scRNA-seq analysis identified 12distinct cell types and 22 clusters,with secretory epithelial cells(SECs)exhibiting marked expression of plasma cell markers,including IGLL1 and MZB1.RNA fluorescence in situ hybridization(RNA FISH)and IgY quantification confirmed the critical role of SECs in producing endogenous IgY during lactation.We propose that fibroblast-derived BAFF signals activate SECs,mimicking B cell transformation and enhancing protein production through the unfolded protein response(UPR).These findings shed light on the cellular dynamics of pigeon milk production and contribute to a broader understanding of avian biology.展开更多
Objective:While immunotherapy holds great potential for triple-negative breast cancer(TNBC),the lack of non-invasive biomarkers to identify beneficiaries limits the application.Methods:Paired baseline,on-treatment,and...Objective:While immunotherapy holds great potential for triple-negative breast cancer(TNBC),the lack of non-invasive biomarkers to identify beneficiaries limits the application.Methods:Paired baseline,on-treatment,and post-treatment plasma samples were collected from 195 TNBC patients receiving anti-PD-1 immunotherapy in this retrospective study conducted at the Fudan University Shanghai Cancer Center(FUSCC)for sequential high-precision proteomic profiling.Results:ARG1,NOS3,and CD28 were identified as plasma proteins significantly associated with the response to immunotherapy in neoadjuvant settings or in advanced stages of TNBC.Matched single-cell RNA sequencing data were incorporated to correlate peripheral plasma with the tumor microenvironment.Furthermore,the Plasma Immuno Prediction Score was developed to demonstrate significant predictive power for evaluating the efficacy and prognosis of patients undergoing neoadjuvant immunotherapy.Conclusions:The results underscore the importance of systemic immunity in the immunotherapy response and support the use of plasma protein profiles as a feasible tool for enhancing personalized management of immunotherapy in breast cancer.展开更多
Objectives:Despite the considerable regenerative capacity exhibited by adipose-derived mesenchymal stem cells(ASCs),their genetic and molecular mechanisms remain incompletely understood.Methods:In this study,we analyz...Objectives:Despite the considerable regenerative capacity exhibited by adipose-derived mesenchymal stem cells(ASCs),their genetic and molecular mechanisms remain incompletely understood.Methods:In this study,we analyzed the global gene expression profile of adipose-derived mesenchymal stem cells(ASCs)using microarray analysis and compared it with stromal vascular fraction(SVF)cells.Results:Microarray analysis revealed that ASCs express elevated levels of genes related to the extracellular matrix(ECM;extracellular matrix)and collagen,which are critical components of tissue remodeling and wound healing.Additionally,genes associated with cell growth,differentiation,motility,and plasticity were highly expressed.When compared to stromal vascular fraction(SVF)cells,ASCs demonstrated enrichment of genes involved in anti-inflammatory responses,immune modulation,tissue repair,cell adhesion,and migration processes.Gene Set Enrichment Analysis(GSEA;Gene Set Enrichment Analysis)showed activation of pathways related to angiogenesis,such as vascular endothelial growth factor(VEGF),Integrin,Wnt signaling pathways,transforming growth factor-beta(TGF-β),extracellular matrix(ECM),and matrix metalloproteinase(MMP),highlighting the significant angiogenic potential of ASCs.Gene Ontology(GO;Gene Ontology)analysis further linked ASCs to biological processes associated with the regulation of cell proliferation and muscle cell differentiation.Conclusion:These findings collectively underscore the suitability of adipose-derived mesenchymal stem cells(ASCs)as a promising candidate for regenerative medicine,particularly in applications involving tissue repair,immune modulation,and promotion of angiogenesis.展开更多
Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemome...Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemometric analysis.Additionally,network pharmacology was employed to investigate the possible mechanisms of action of L.japonicum in the urinary calculi(UC)treatment.Methods:A fingerprinting method was established to identify components through UHPLC-tandem mass spectrometry.Chemometric techniques were used to compare the L.japonicum extraction methods.Furthermore,various network pharmacological approaches were used to identify and analyze the potential targets of the identified components in relation to UC.Results:The W and S extracts were distributed into two distinct clusters.Significant differences in the levels of protocatechuic aldehyde,caffeic acid,and p-coumaric acid were observed between S and W.Network pharmacology analysis revealed that the primary targets of L.japonicum in the UC treatment were serum albumin and epidermal growth factor receptors,with potential active components including protocatechuic acid and caffeic acid.Conclusion:This study comprehensively examined the therapeutic components of L.japonicum before and after boiling,shedding light on its potential mechanisms of action in UC treatment.These findings offer valuable insights into the development and utilization of L.japonicum resources.展开更多
BACKGROUND Psoriasis is a chronic inflammatory condition related to an increased athero-sclerotic cardiovascular disease(ASCVD)risk.AIM To investigate whether lipoprotein(a)[Lp(a)]levels are increased in patients with...BACKGROUND Psoriasis is a chronic inflammatory condition related to an increased athero-sclerotic cardiovascular disease(ASCVD)risk.AIM To investigate whether lipoprotein(a)[Lp(a)]levels are increased in patients with psoriasis.METHODS A comprehensive literature search up to January 30,2025 was conducted utilizing PubMed and Cochrane Library databases.A qualitative synthesis and a meta-analysis on Lp(a)mean differences(MD)between psoriasis cases and healthy controls(HC)was performed.The protocol of this meta-analysis has been re-gistered to PROSPERO(No.CRD420250652465).RESULTS Eighteen studies with 1650 psoriasis patients and 1621 HC were eligible for qua-litative synthesis.Pooled analysis from 16 studies(1401 psoriasis patients and 1320 HC)demonstrated that psoriasis patients had significantly higher Lp(a)levels compared with the HC group(MD:6.72 mg/dL,95%CI:4.32-9.12,P<0.00001,I2=71%).Sensitivity analyses according to the region of origin was also performed.The pooled analysis of the European sub-population showed a pronounced increase in Lp(a)levels in 189 patients with psoriasis vs 178 HC(MD:15.86 mg/dL,95%CI:5.79-25.92,P<0.002,I2=79%),while the pooled analysis on the Asian sub-population demonstrated a smaller but still significant difference in Lp(a)levels between 1177 psoriasis patients and 1127 HC(MD:4.95 mg/dL,95%CI:2.99-6.92,P<0.00001,I2=58%).CONCLUSION Our findings suggest that Lp(a)levels are significantly elevated in psoriasis patients,further adding to their ASCVD risk.展开更多
This study examines the coupling analysis between box roll motion response and free surface oscillation in a narrow gap,utilizing a two-box system comprising a small roll box and a large fixed box.The potential flow m...This study examines the coupling analysis between box roll motion response and free surface oscillation in a narrow gap,utilizing a two-box system comprising a small roll box and a large fixed box.The potential flow model reveals a two-peak variation in both roll motion response and free surface oscillation across incident wave frequencies.Free decay tests indicate that these frequencies correspond to the first and second resonant frequencies of the roll-fixed two-box system.Viscous fluid flow model simulations demonstrate a two-peak behavior in roll motion response,while free surface oscillation exhibits a single peak near the second resonant frequency.Repositioning the small roll box from upstream to downstream results in increased roll motion amplitude around the first resonant frequency.The roll-box with round edge profiles exhibits beating behavior in motion response,resulting in increased roll motion amplitude across a broad frequency range.Notably,wave energy at the first resonant frequency component remains undamped by round edge profiles.展开更多
The current study conducted the psychological capital profiles and the relation between profile memberships and learning burnout among undergraduates.Participants were 541 Chinese undergraduates ranging from 18 to 21 ...The current study conducted the psychological capital profiles and the relation between profile memberships and learning burnout among undergraduates.Participants were 541 Chinese undergraduates ranging from 18 to 21 years old(48.2%male;Mean years=19.54,SD=1.09 years).Latent profile analysis revealed three categories of psychological capital profile consistent high psychological capital profile(50.5%),consistent low psychological capital profile(38.1%),and dominate loss-orientated psychological capital profile(11.4%).The undergraduates in consistent high profile reported high self-efficacy,resilience,hope,and optimism.Consistent low profile characterized by a little low(~0.50 SD below the M)self-efficacy,resilience,hope,and optimism.Dominant loss-orientated profile displayed low self-efficacy,hope,optimism,but a little relatively high resilience.Specifically,undergraduates in consistent high profile exhibited low level of learning burnout;while undergraduates with low level of psychological capital(i.e.,consistent low profile and dominate loss-orientated profile)reported high level of learning burnout.The findings have theoretical significance which provides important knowledge about psychological capital profile among Chinese undergraduates.They have practical implications for student counselling and development providing person-centric support to students based on their individual psychological profiles.展开更多
The operation furnace profile for the high heat load zone was one of the important factors affecting the stable and high-quality production of the blast furnace,but it was difficult to monitor directly.To address this...The operation furnace profile for the high heat load zone was one of the important factors affecting the stable and high-quality production of the blast furnace,but it was difficult to monitor directly.To address this issue,an online calculation model for the operation furnace profile was proposed based on a dual-driven approach combining data and mechanisms,by integrating mechanism experiment,numerical simulation,and machine learning.The experimentally determined slag layer hanging temperature was 1130℃,and the thermal conductivity ranged from 1.32 to 1.96 m^(2)℃^(-1).Based on the 3D slag-hanging numerical simulation model,a database was constructed,containing 2294 sets of mechanism cases for the slag layer.The fusion of data modeling,heat transfer theory,and expert experience enabled the online calculation of key input variables for the operation furnace profile,particularly the quantification of the“black-box”variable of gas temperature.Simulated data were used as inputs,and light gradient boosting machine was applied to construct the online calculation model for the operation furnace profile.This model facilitated the online calculation of the slag layer thickness and other key indices.The coefficient of determination of the model exceeded 0.98,indicating high accuracy.A slag layer state judgment model was constructed,categorizing states as shedding,too thin,normal,and too thick.Real-time data were applied,and the average slag thickness in the high heat load area of the test data ranged from 40 to 80 mm,which was consistent with field experience.The absolute value of the Pearson correlation coefficient between slag layer thickness,thermocouple temperature,and heat load data was above 0.85,indicating that the calculated results closely aligned with the actual trends.A 3D visual online monitoring system for the operation furnace profile was created,and it has been successfully implemented at the blast furnace site.展开更多
Geared-rotor systems are critical components in mechanical applications,and their performance can be severely affected by faults,such as profile errors,wear,pitting,spalling,flaking,and cracks.Profile errors in gear t...Geared-rotor systems are critical components in mechanical applications,and their performance can be severely affected by faults,such as profile errors,wear,pitting,spalling,flaking,and cracks.Profile errors in gear teeth are inevitable in manufacturing and subsequently accumulate during operations.This work aims to predict the status of gear profile deviations based on gear dynamics response using the digital model of an experimental rig setup.The digital model comprises detailed CAD models and has been validated against the expected physical behavior using commercial finite element analysis software.The different profile deviations are then modeled using gear charts,and the dynamic response is captured through simulations.The various features are then obtained by signal processing,and various ML models are then evaluated to predict the fault/no-fault condition for the gear.The best performance is achieved by an artificial neural network with a prediction accuracy of 97.5%,which concludes a strong influence on the dynamics of the gear rotor system due to profile deviations.展开更多
基金supported by MKE(The Ministry of Knowledge Economy),Koreathe ITRC support program supervised by the NIPA(NIPA-2009-(C1090-0902-0007))
文摘Business Process Exeention Language （BPEL） is being used in various applications as the standard of workflow. As the requirerments increase to describe application processes in BPEL, BPEL documentt is getting more Complplicated. Therefore it is difficult to describe applications in BPEL with high reliability. In order to write highly reliable BPEL document, it is necessary to check if the document is working correctly in accordance with user＇s intention. But it is difficult to carry out the test since BPEL engine doesn＇t provide a profiling function. In this paper, we suggest a BPEL system with a real-time profiling function. The suggested system consists of an integrated development environment and a BPEL nunning environment. BPEL integrated development environment has a BPEL to Java（B2J） engine, which generates and executes a Java workflow program from a BPEL document, and a converter, which converts Java Weaving XML （JWX） documents to Aspect-oriented programs. The new functions are described in JWX, which is Extensive Markup Lan-guage （XML）-based document. Since aspect-oriented programming technique provides the way to modularize main and supplemental requirements, it guarantees the low degree of coupling between BPEL workflow program and new functions by weaving them. Our approach can be extended to add other functions to provide context-aware services.
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2023-01-02126).
文摘The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract(ASE)by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase(MMP),collagenase,elastase,hyaluronidase,and tyrosinase in relation to its chemical composition.Ultra Performance Liquid Chromatography-Mass Spectrometry(UPLC-MS)identified 27 metabolites(15 flavonoids,8 phenolic acids and their derivatives,and 4 coumarins).ASE showed strong antioxidant capacity in DPPH(IC_(50)value of 26.05μg/mL)and FRAP(2433μM FeSO_(4)/g extract)assays.The extract inhibited MMP-1 and MMP-9 in a concentration-dependent manner and suppressed collagenase,elastase,hyaluronidase,and tyrosinase activities(IC_(50)=35.038,40.748,61.389,and 30.980μg/mL,respectively).A network pharmacology study was conducted to uncover the mechanisms responsible for skin anti-aging effects,and molecular docking further evaluated interactions of key metabolites with hub targets.Twenty-one bioactive metabolites,selected based on oral bioavailability and drug-likeness,highlighted cinnamic acid,acacetin,luteolin,kaempferol,and apigenin as key compounds.MMP-9,ESR1,PTGS-2,and EGFR were identified as main targets.Docking studies revealed that acacetin and apigenin have stronger binding affinities to MMP-9,PTGS-2,and EGFR than other constituents.These findings suggest that ASE may serve as a natural multi-target skin anti-aging remedy with potential cosmetic applications.
基金funded by the Agricultural Development Program through Science and Technology of Shanghai,China (2022-02-08-00-12-F01099)the National Key R&D Program of China (2023YFD1201501)+1 种基金the Science and Technology Commission of Shanghai Municipality,China (22DX1900100)the Excellent Team Project of Shanghai Academy of Agricultural Sciences,China (2022(007))。
文摘Head-splitting is a prevalent physiological disorder in cabbage that causes substantial economic losses.However,the genetic factors and molecular mechanisms underlying head-splitting resistance remain largely unexplored.This study identified a genomic region(q NLQ3.1) for head-splitting resistance on chromosome C03 through the combination of QTLseq and GPS analysis in an F_(2) population derived from hybridizing two cabbage inbred lines,‘Dazhengfu'(ZF,susceptible) and ‘103'(resistant).Traditional genetic linkage analysis narrowed q NLQ3.1 to a 74.6 kb region.Furthermore,comparative analysis of the two parental lines using transcriptomic and metabolic profiling demonstrated the crucial role of hormones in regulating head-splitting resistance.Bol028000,encoding a homologue of Arabidopsis Cytokinin Response Factor 3(CRF3),emerged as a promising candidate for head-splitting resistance and was subsequently validated through Sanger sequencing and quantitative RT-PCR(qRT-PCR).Subcellular localisation analysis revealed that Bol028000 was mainly expressed in the nucleus.Additionally,one kompetitive allele-specific PCR(KASP) marker from Bol028000 was developed and utilized to screen 42 inbred lines.These findings enhance the theoretical understanding of head-splitting resistance and provide valuable insights for the molecular breeding of head-splitting resistant cabbages.
基金Supported by the National Natural Science Foundation of China(Nos.U23A2033,41976154)the Key R&D Program of Zhejiang Province,China(No.2023C03011)+2 种基金the Key R&D Program of Guangxi,China(No.Guike AB22080099)the Science Foundation of Donghai Laboratory(No.DH-2022KF0205)the Bureau of Science and Technology of Zhoushan(No.2022C81006)。
文摘Global warming underscores the urgent need to enhance carbon sinks to mitigate climate change,yet the role of coastal shellfish aquaculture area as either carbon sinks or sources remains unclear.In this study,we conducted high-resolution profiling observations of CO_(2)dynamics and net community production(NCP)in a mussel farm located in the Changjiang(Yangtze)River estuary(CRE)during early autumn.Results indicate that the partial pressure of CO_(2)(pCO_(2))in the water column was consistently higher than the atmospheric level,averaging 74.75±2.44 Pa,signaling that the mussel farm acted as a CO_(2)source.The average air-water CO_(2)exchange flux(FCO_(2))averaged-1.91±1.16 mmol/(m^(2)·h),and NCP in the water column(NCPCOL)averaged-6.66±12.81 mmol/(m^(2)·h),revealing a heterotrophic condition.A significant inverse correlation was found between NCPCOLand sea surface pCO_(2)with a lag time of approximately 3.31 h,highlighting the influence of biological activity in modulating CO_(2)dynamics.Physical processes such as freshwater inputs,vertical mixing,and wind patterns,also played a crucial role in shaping pCO_(2)variations.The study emphasizes the complexity of CO_(2)dynamics in costal aquaculture areas and the need for long-term,high-resolution monitoring to better understand their contribution to climate change mitigation.The high-resolution profiling system provided novel insights into the dynamics of NCP and CO_(2)fluxes,showing its potential as an advanced tool for studying aquaculture systems.Future research should focus on expanding the geographic and temporal scope of studies,combining observational and modeling approaches to better predict the responses of aquaculture systems to environmental changes.
基金The project was financially supported by the High Tech Research and Development (863) Program (Grant No2005AA604220)by a grant from China National Offshore Oil Corporation (Grant No051100036)
文摘There is a need to obtain the hydrologic data including ocean current, wave, temperature and so on in the South China Sea. A new profiling instrument which does not suffer from the damage due to nature forces or incidents caused by passing ships, is under development to acquire data from this area. This device is based on a taut single point mid-water mooring system. It incorporates a small, instrumented vertically profiling float attached via an electromechanical cable to a winch integral with the main subsurface flotation. On a pre-set schedule, the instrument float with sensors is winched up to the surface if there is no ship passing by, which is defined by an on-board miniature sonar. And it can be. inunediately winched down to a certain depth if the sonar sensor finds something is coming. Since, because of logistics, the area can only be visited once for a long time and a minimum of 10 times per day profiles are desired, energy demands are severe. To respond to these concerns, the system has been designed to conserve a substantial portion of the potential energy lost during the ascent phase of each profile and subsequently use this energy to pull the instrument down. Compared with the previous single-point layered measuring mode, it is advanced and economical. At last the paper introduces the test in the South China Sea.
基金the National High Technology Project of China Foundation under Grant No.2002AA602230-1
文摘A multi-beam chirp sonar based on IP connections and DSP processing nodes was proposed and designed to provide an expandable system with high-speed processing and mass-storage of real-time signals for multi-beam profiling sonar.The system was designed for seabed petroleum pipeline detection and orientation,and can receive echo signals and process the data in real time,refreshing the display 10 times per second.Every node of the chirp sonar connects with data processing nodes through TCP/IP. Merely by adding nodes,the system’s processing ability can be increased proportionately without changing the software.System debugging and experimental testing proved the system to be practical and stable.This design provides a new method for high speed active sonar.
基金The National Natural Science Foundation of China under contract Nos 42106022 and 42106024the National Key Research and Development Program of China under contract No.2021YFC3101502+2 种基金the Fund of Laoshan Laboratory under contract No.LSKJ202201500the Fund of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract No.SML2021SP102the Fund of Chinese Academy of Sciences under contract Nos 133244KYSB20190031,183311KYSB20200015,and SCSIO202201。
文摘Over the past two decades,numerous countries have actively participated in the International Argo Program,working toward the global“OneArgo”goal.China's Argo program has deployed over 500 autonomous profiling floats in the Indo-Pacific,with 55 Beidou(BD)floats,equipped with the Beidou satellite communication system,currently operational.During the operation of the BD float network,we found that in addition to the limitation of floats battery,the loss may also be caused by communication loss due to the floats escaping from the Beidou-2's short message coverage.In this study,float trajectories are simulated using velocity fields from an eddy-resolved resolution Estimating the Circulation and Climate of the Ocean,PhaseⅡ(ECCO2)model and a Lagrangian particle tracking model programmed to represent the vertical motions of profiling floats.The simulations can help to explore both the representativeness and the predictability of profiling float displacements.By deploying a large number of synthetic floats in the Lagrangian particle tracking system,we construct probability density functions(PDFs)of the simulated-float trajectory among key oceans,for example,a joint region of East Indian-South China Sea-Northwest Pacific Ocean(5°–40°N,70°–140°E),which is generally similar to the location of the present BD float network.These statistics can help to estimate the chance of floats drifting into shallow seas(such as the East China Sea)and out of the coverage of the Beidou satellite communication.With this knowledge changes to the future China's Argo observing system could be made.
基金funded by the 2023 Hospital Management Innovation Research Project by the Jiangsu Hospital Association(No.JSYGY-2-2023-551)。
文摘Objectives:This study aimed to explore the effectiveness and advantages of an“Internet+”nursing model based on user profilingin the rehabilitation of postoperative breast cancer patients.Methods:Breast cancer patients admitted to the hospital from July 2023 to September 2024 were enrolled.These patients were randomly assigned to a control group and an intervention group,with 52 patients in each group.The control group received routine nursing care,while the intervention group received an“Internet+”nursing intervention based on user profilingin addition to routine care.The intervention period lasted for one month following discharge.Before and one month after the intervention,the Fear of Progression Questionnaire-Short Form(FOP-Q-SF),the Fear of Cancer Recurrence Inventory-Short Form(FCRI-SF),Chinese Posttraumatic Growth Inventory(C-PTGI),and the Functional Assessment of Cancer Therapy-Breast(FACT-B)were applied to assess the effects of interventions.Results:A total of 104 patients were analyzed.After the intervention,FOP-Q-SF and FCRI-SF scores were significantlylower in the intervention group compared to the control group,with statistical significance(t=3.98,P<0.001;t=-7.59,P<0.001),and Cohen’s d of 0.781 and 1.49,respectively.Additionally,CPTGI and FACT-B scores in the intervention group were significantly higher than those in the control group(t=-6.534,P<0.001;t=-4.579,P<0.001),with Cohen’s d of 0.585 and 0.656.Conclusions:An“Internet+”nursing model based on user profilingcould reduce postoperative breast cancer patients fear of disease progression and cancer recurrence,also enhancing posttraumatic growth and overall quality of life.
基金support from the Science Research Program Project for Drug Regulation,Jiangsu Medical Products Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.
文摘Chronic diarrhea remains a frequent and debilitating complication among individuals living with HIV,particularly in the context of advanced immunosuppression.Its multifactorial nature often complicates both diagnosis and treatment.We present insights from our recent study investigating gut microbial alterations using 16S rRNA sequencing in HIV-positive patients with diarrheal syndrome of unclear etiology.
基金supported by the Shanghai Sailing Program(22YF1416300)Youth Fund Project of National Natural Science Foundation of China(32202117)+1 种基金National Key Research and Development Program of China(2022YFD2100104)the China Agriculture Research System(CARS-47).
文摘Bigeye tuna is a protein-rich fish that is susceptible to spoilage during cold storage,however,there is limited information on untargeted metabolomic profiling of bigeye tuna concerning spoilage-associated enzymes and metabolites.This study aimed to investigate how cold storage affects enzyme activities,nutrient composition,tissue microstructures and spoilage metabolites of bigeye tuna.The activities of cathepsins B,H,L increased,while Na^(+)/K^(+)-ATPase and Mg^(2+)-ATPase decreased,α-glucosidase,lipase and lipoxygenase first increased and then decreased during cold storage,suggesting that proteins undergo degradation and ATP metabolism occurs at a faster rate during cold storage.Nutrient composition(moisture and lipid content),total amino acids decreased,suggesting that the nutritional value of bigeye tuna was reduced.Besides,a logistic regression equation has been established as a food analysis tool and assesses the dynamics and correlation of the enzyme of bigeye tuna during cold storage.Based on untargeted metabolomic profiling analysis,a total of 524 metabolites were identified in the bigeye tuna contained several spoilage metabolites involved in lipid metabolism(glycerophosphocholine and choline phosphate),amino acid metabolism(L-histidine,5-deoxy-5′-(methylthio)adenosine,5-methylthioadenosine),carbohydrate metabolism(D-gluconic acid,α-D-fructose 1,6-bisphosphate,D-glyceraldehyde 3-phosphate).The results of tissue microstructures of tuna showed a looser network and visible deterioration of tissue fiber during cold storage.Therefore,metabolomic analysis and tissue microstructures provide insight into the spoilage mechanism investigations on bigeye tuna during cold storage.
基金supported by the Department of Agriculture and Rural Affairs of Jiangxi Province,China (JXARS-09)Science and Technology Program of Guangdong Province,China (2020B1212060060)。
文摘Pigeons and certain other avian species produce a milklike secretion in their crop sacs to nourish offspring,yet the detailed processes involved are not fully elucidated.This study investigated the crop sacs of 225-day-old unpaired non-lactating male pigeons(MN)and males initiating lactation on the first day after incubation(ML).Using RNA sequencing,ribosomeprofiling,andsingle-cell transcriptome sequencing(scRNA-seq),we identified a significant up-regulation of genes associated with ribosome assembly and protein synthesis in ML compared to MN.Results from scRNA-seq analysis identified 12distinct cell types and 22 clusters,with secretory epithelial cells(SECs)exhibiting marked expression of plasma cell markers,including IGLL1 and MZB1.RNA fluorescence in situ hybridization(RNA FISH)and IgY quantification confirmed the critical role of SECs in producing endogenous IgY during lactation.We propose that fibroblast-derived BAFF signals activate SECs,mimicking B cell transformation and enhancing protein production through the unfolded protein response(UPR).These findings shed light on the cellular dynamics of pigeon milk production and contribute to a broader understanding of avian biology.
基金supported by the National Key Research and Development Project of China(Grant No.2021YFF1201300 and 2021YFF1201302)the Shanghai Committee of Science and Technology(Grant No.24DX2800100)the Institutional Projects of SIBPT(Grant No.YZ2024-07)。
文摘Objective:While immunotherapy holds great potential for triple-negative breast cancer(TNBC),the lack of non-invasive biomarkers to identify beneficiaries limits the application.Methods:Paired baseline,on-treatment,and post-treatment plasma samples were collected from 195 TNBC patients receiving anti-PD-1 immunotherapy in this retrospective study conducted at the Fudan University Shanghai Cancer Center(FUSCC)for sequential high-precision proteomic profiling.Results:ARG1,NOS3,and CD28 were identified as plasma proteins significantly associated with the response to immunotherapy in neoadjuvant settings or in advanced stages of TNBC.Matched single-cell RNA sequencing data were incorporated to correlate peripheral plasma with the tumor microenvironment.Furthermore,the Plasma Immuno Prediction Score was developed to demonstrate significant predictive power for evaluating the efficacy and prognosis of patients undergoing neoadjuvant immunotherapy.Conclusions:The results underscore the importance of systemic immunity in the immunotherapy response and support the use of plasma protein profiles as a feasible tool for enhancing personalized management of immunotherapy in breast cancer.
基金supported through National Research Foundation(NRF)of Korea grants funded by the Korean Government(No.NRF-2022R1F1A1064405)the research fund of Catholic Kwandong University and Catholic Kwandong University International St.Mary’s Hospital for S.-W Kim.
文摘Objectives:Despite the considerable regenerative capacity exhibited by adipose-derived mesenchymal stem cells(ASCs),their genetic and molecular mechanisms remain incompletely understood.Methods:In this study,we analyzed the global gene expression profile of adipose-derived mesenchymal stem cells(ASCs)using microarray analysis and compared it with stromal vascular fraction(SVF)cells.Results:Microarray analysis revealed that ASCs express elevated levels of genes related to the extracellular matrix(ECM;extracellular matrix)and collagen,which are critical components of tissue remodeling and wound healing.Additionally,genes associated with cell growth,differentiation,motility,and plasticity were highly expressed.When compared to stromal vascular fraction(SVF)cells,ASCs demonstrated enrichment of genes involved in anti-inflammatory responses,immune modulation,tissue repair,cell adhesion,and migration processes.Gene Set Enrichment Analysis(GSEA;Gene Set Enrichment Analysis)showed activation of pathways related to angiogenesis,such as vascular endothelial growth factor(VEGF),Integrin,Wnt signaling pathways,transforming growth factor-beta(TGF-β),extracellular matrix(ECM),and matrix metalloproteinase(MMP),highlighting the significant angiogenic potential of ASCs.Gene Ontology(GO;Gene Ontology)analysis further linked ASCs to biological processes associated with the regulation of cell proliferation and muscle cell differentiation.Conclusion:These findings collectively underscore the suitability of adipose-derived mesenchymal stem cells(ASCs)as a promising candidate for regenerative medicine,particularly in applications involving tissue repair,immune modulation,and promotion of angiogenesis.
基金supported by Ministry of Industry and Information Technology of the People's Republic of China 2022 Industrial Technology Basic Public Service Platform Project-Traditional Chinese Medicine Whole Industry Chain Quality and Technology Service Platform(2022-230-221)Foshan Nanhai District Key Area Science and Technology Research Project[Nanke(2023)20-18].
文摘Objective:To evaluate the quality of Lygodium japonicum(Thunb.)Sw.(L.japonicum,Hai Jin Sha)by comparing its components without stewed(W)and stewed(S)using ultra-high-performance liquid chromatography(UHPLC)and chemometric analysis.Additionally,network pharmacology was employed to investigate the possible mechanisms of action of L.japonicum in the urinary calculi(UC)treatment.Methods:A fingerprinting method was established to identify components through UHPLC-tandem mass spectrometry.Chemometric techniques were used to compare the L.japonicum extraction methods.Furthermore,various network pharmacological approaches were used to identify and analyze the potential targets of the identified components in relation to UC.Results:The W and S extracts were distributed into two distinct clusters.Significant differences in the levels of protocatechuic aldehyde,caffeic acid,and p-coumaric acid were observed between S and W.Network pharmacology analysis revealed that the primary targets of L.japonicum in the UC treatment were serum albumin and epidermal growth factor receptors,with potential active components including protocatechuic acid and caffeic acid.Conclusion:This study comprehensively examined the therapeutic components of L.japonicum before and after boiling,shedding light on its potential mechanisms of action in UC treatment.These findings offer valuable insights into the development and utilization of L.japonicum resources.
文摘BACKGROUND Psoriasis is a chronic inflammatory condition related to an increased athero-sclerotic cardiovascular disease(ASCVD)risk.AIM To investigate whether lipoprotein(a)[Lp(a)]levels are increased in patients with psoriasis.METHODS A comprehensive literature search up to January 30,2025 was conducted utilizing PubMed and Cochrane Library databases.A qualitative synthesis and a meta-analysis on Lp(a)mean differences(MD)between psoriasis cases and healthy controls(HC)was performed.The protocol of this meta-analysis has been re-gistered to PROSPERO(No.CRD420250652465).RESULTS Eighteen studies with 1650 psoriasis patients and 1621 HC were eligible for qua-litative synthesis.Pooled analysis from 16 studies(1401 psoriasis patients and 1320 HC)demonstrated that psoriasis patients had significantly higher Lp(a)levels compared with the HC group(MD:6.72 mg/dL,95%CI:4.32-9.12,P<0.00001,I2=71%).Sensitivity analyses according to the region of origin was also performed.The pooled analysis of the European sub-population showed a pronounced increase in Lp(a)levels in 189 patients with psoriasis vs 178 HC(MD:15.86 mg/dL,95%CI:5.79-25.92,P<0.002,I2=79%),while the pooled analysis on the Asian sub-population demonstrated a smaller but still significant difference in Lp(a)levels between 1177 psoriasis patients and 1127 HC(MD:4.95 mg/dL,95%CI:2.99-6.92,P<0.00001,I2=58%).CONCLUSION Our findings suggest that Lp(a)levels are significantly elevated in psoriasis patients,further adding to their ASCVD risk.
基金supported by the National Natural Science Foundation of China(Grant Nos.52371267 and 52171250)。
文摘This study examines the coupling analysis between box roll motion response and free surface oscillation in a narrow gap,utilizing a two-box system comprising a small roll box and a large fixed box.The potential flow model reveals a two-peak variation in both roll motion response and free surface oscillation across incident wave frequencies.Free decay tests indicate that these frequencies correspond to the first and second resonant frequencies of the roll-fixed two-box system.Viscous fluid flow model simulations demonstrate a two-peak behavior in roll motion response,while free surface oscillation exhibits a single peak near the second resonant frequency.Repositioning the small roll box from upstream to downstream results in increased roll motion amplitude around the first resonant frequency.The roll-box with round edge profiles exhibits beating behavior in motion response,resulting in increased roll motion amplitude across a broad frequency range.Notably,wave energy at the first resonant frequency component remains undamped by round edge profiles.
基金supported by Hunan Province Education Department Outstanding Youth Project(23B1131)Hunan Province Education Science Fourteenth Five-Year Plan Project(XJK24BXL003).
文摘The current study conducted the psychological capital profiles and the relation between profile memberships and learning burnout among undergraduates.Participants were 541 Chinese undergraduates ranging from 18 to 21 years old(48.2%male;Mean years=19.54,SD=1.09 years).Latent profile analysis revealed three categories of psychological capital profile consistent high psychological capital profile(50.5%),consistent low psychological capital profile(38.1%),and dominate loss-orientated psychological capital profile(11.4%).The undergraduates in consistent high profile reported high self-efficacy,resilience,hope,and optimism.Consistent low profile characterized by a little low(~0.50 SD below the M)self-efficacy,resilience,hope,and optimism.Dominant loss-orientated profile displayed low self-efficacy,hope,optimism,but a little relatively high resilience.Specifically,undergraduates in consistent high profile exhibited low level of learning burnout;while undergraduates with low level of psychological capital(i.e.,consistent low profile and dominate loss-orientated profile)reported high level of learning burnout.The findings have theoretical significance which provides important knowledge about psychological capital profile among Chinese undergraduates.They have practical implications for student counselling and development providing person-centric support to students based on their individual psychological profiles.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52404343 and 52274326)the Fundamental Research Funds for the Central Universities(Grant Nos.N2425031 and N25BJD007)+1 种基金the China Postdoctoral Science Foundation(Grant No.2024M760370)the Liaoning Province Science and Technology Plan Joint Program(Key Research and Development Program Project)(Grant No.2023JH2/101800058).
文摘The operation furnace profile for the high heat load zone was one of the important factors affecting the stable and high-quality production of the blast furnace,but it was difficult to monitor directly.To address this issue,an online calculation model for the operation furnace profile was proposed based on a dual-driven approach combining data and mechanisms,by integrating mechanism experiment,numerical simulation,and machine learning.The experimentally determined slag layer hanging temperature was 1130℃,and the thermal conductivity ranged from 1.32 to 1.96 m^(2)℃^(-1).Based on the 3D slag-hanging numerical simulation model,a database was constructed,containing 2294 sets of mechanism cases for the slag layer.The fusion of data modeling,heat transfer theory,and expert experience enabled the online calculation of key input variables for the operation furnace profile,particularly the quantification of the“black-box”variable of gas temperature.Simulated data were used as inputs,and light gradient boosting machine was applied to construct the online calculation model for the operation furnace profile.This model facilitated the online calculation of the slag layer thickness and other key indices.The coefficient of determination of the model exceeded 0.98,indicating high accuracy.A slag layer state judgment model was constructed,categorizing states as shedding,too thin,normal,and too thick.Real-time data were applied,and the average slag thickness in the high heat load area of the test data ranged from 40 to 80 mm,which was consistent with field experience.The absolute value of the Pearson correlation coefficient between slag layer thickness,thermocouple temperature,and heat load data was above 0.85,indicating that the calculated results closely aligned with the actual trends.A 3D visual online monitoring system for the operation furnace profile was created,and it has been successfully implemented at the blast furnace site.
文摘Geared-rotor systems are critical components in mechanical applications,and their performance can be severely affected by faults,such as profile errors,wear,pitting,spalling,flaking,and cracks.Profile errors in gear teeth are inevitable in manufacturing and subsequently accumulate during operations.This work aims to predict the status of gear profile deviations based on gear dynamics response using the digital model of an experimental rig setup.The digital model comprises detailed CAD models and has been validated against the expected physical behavior using commercial finite element analysis software.The different profile deviations are then modeled using gear charts,and the dynamic response is captured through simulations.The various features are then obtained by signal processing,and various ML models are then evaluated to predict the fault/no-fault condition for the gear.The best performance is achieved by an artificial neural network with a prediction accuracy of 97.5%,which concludes a strong influence on the dynamics of the gear rotor system due to profile deviations.
