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Hydrological Process Factors Analysis of Heihe River Mountain Basin Based on GIS 被引量:8
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作者 黄清华 杨永国 陈玉华 《Agricultural Science & Technology》 CAS 2010年第3期147-150,共4页
Hydrological process factors are a reflection of the physical mechanism of basin hydrology,which can provide important basis for the use and protection of water resources.Taking Heihe River Mountain Basin as the study... Hydrological process factors are a reflection of the physical mechanism of basin hydrology,which can provide important basis for the use and protection of water resources.Taking Heihe River Mountain Basin as the study area,the hydrological simulation was made based on SWAT-GIS integrated model platform.The calculation methods of hydrological process factors using SWAT model were described based on the simulation results of runoff from 1990 to 2000.Hydrological process factors in the study area were analyzed by using GIS technology.The spatial and temporal characteristics of precipitation,runoff,infiltration,evapotranspiration and snowmelt in the basin were calculated and analyzed. 展开更多
关键词 GIS Hydrological process factors SWAT Heihe River Basin
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Effect of Process Factors on Microstructure of Semisolid Continuous Casting Billets 被引量:1
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作者 Shuming Xing, Qijie Zhai, Hanqi Hu ( Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China School of Material Science and Engineering, Shanghai University, Shanghai 200072, China Material Science and Engineering School, Univer 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2000年第4期242-245,共4页
Semisolid continuous casting (SSCC) is a new technology to produce billets for semisolid metal forming (SSMF). The effect of process factors, such as pouring temperature, stirring rate, preheating temperature and ther... Semisolid continuous casting (SSCC) is a new technology to produce billets for semisolid metal forming (SSMF). The effect of process factors, such as pouring temperature, stirring rate, preheating temperature and thermal conductivity of stirring chamber, on the microstructure of SSCC billets was studied by means of the factorial experimental method. The results show that the microstructure of SSCC billets can be controlled by the above-mentioned four process factors. In order to obtain fine and rounded granular grains in an SSCC billet, the pouring temperature, preheating temperature and stirring rate should be kept in a moderate range, and the thermal conductivity of stirring chamber should be high. The regression equations with the process factors connecting the microstructure was also set up based on experimental data. 展开更多
关键词 semisolid metal continuous casting process factors microstructure Metallurgy
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Influence of Process Factors on Electrode Wear Rate when EDM 90CrSi Steel using Graphite Electrodes
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作者 Tran Huu Danh Le Thi Phuong Thao +2 位作者 Nguyen Thi Quoc Dung Vu Trung Tuyen Luu Anh Tung 《Journal of Environmental Science and Engineering(B)》 2023年第5期230-235,共6页
The findings of a study on the optimization of Electric Discharge Machining(EDM)procedure for processing cylindrically shaped components with graphite electrodes are presented in this paper.Tool steel 90CrSi was the m... The findings of a study on the optimization of Electric Discharge Machining(EDM)procedure for processing cylindrically shaped components with graphite electrodes are presented in this paper.Tool steel 90CrSi was the material of choice for the study’s workpiece.Additionally,the Electrode Wear Rate(EWR)was chosen as the optimization problem’s objective function.An experiment using the Taguchi design was conducted to address this issue.Additionally,experiments were created and their outcomes were analyzed using the Minitab R19 program.The impact of the input process factors on EWR was investigated,including the powder concentration,the pulse on and off times,the servo current,and the servo voltage.Additionally,the best process variables for a minimal EWR were provided. 展开更多
关键词 EDM process factor EWR 90CrSi.
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Electroless Plating of Palladium Membranes on Porous Substrates for Hydrogen Separation and the Effects of Process Factors on Plating Rate and Efficiency: A Review 被引量:1
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作者 Abubakar Alkali 《Journal of Power and Energy Engineering》 2020年第2期1-19,共19页
The electroless plating of palladium and palladium alloy membranes is fast becoming an important and enabling technology. This is more so when juxtaposed with the rising demand for high purity hydrogen for application... The electroless plating of palladium and palladium alloy membranes is fast becoming an important and enabling technology. This is more so when juxtaposed with the rising demand for high purity hydrogen for applications particularly in proton exchange membrane fuel cells (PEMFC). The effect of process factors such as sensitization and activation during surface modification, concentration of the reducing agent, plating temperature, time, pH, additives, air aeration on plating efficiency, quality of the palladium film and deposit morphology is reviewed with the aim of identifying areas requiring further investigation. The paper also reviews how these process factors could be optimised for better plating efficiency and overall membrane quality. The concentration of the reducing agent has been identified as the limiting factor on plating efficiency albeit other process factors separately impact on the plating efficiency. Furthermore, bulk precipitation caused by concentration of the reducing agent has been identified as a major problem during electroless plating with hydrazine based plating baths. To ameliorate this problem, a multi step addition of the hydrazine reducer in separate portions has been recommended. 展开更多
关键词 ELECTROLESS PLATING Hydrogen PALLADIUM Membranes PLATING EFFICIENCY process factorS
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Changing Process and Impact Factors of Ecosystem in Shuangtaizi Estuary Wetland of China 被引量:1
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作者 王永洁 郑冬梅 罗金明 《Journal of Landscape Research》 2011年第5期45-48,51,共5页
By introducing geological and natural conditions of Shuangtaizi Estuary Wetland,a national nature reserve,and borrowing Landsat5 TM wetland data of the year 1987 and 2005,the core area of Shuangtaizi Estuary Wetland i... By introducing geological and natural conditions of Shuangtaizi Estuary Wetland,a national nature reserve,and borrowing Landsat5 TM wetland data of the year 1987 and 2005,the core area of Shuangtaizi Estuary Wetland is studied,areas of its natural water,mudflat,seepweed beach,culture zone,reservoir and swag,reed field,rice field and non-wetland landscape are respectively analyzed,as well as the changes of wetland community,water quality,waterfowl quantity and species.It is found that the study area is suffering from serious fragmentation of wetland,reducing reed yield,degrading water quality,decreasing bird species and amount,which implies that the degraded wetland environment has imposed threats on the survival of some wetland species.Root causes of such a result are analyzed from the perspectives of regional climate changes and human interventions;while regional climate changes include obvious temperature increase and precipitation decrease,human interventions include oil exploration,reclamation of land from the lake,overuse of biotic resources,environment pollution.Due to the interactive influence of these two factors,ecosystem of Shuangtaizi Estuary Wetland has experienced drastic changes,which should be attached sufficient importance by relevant departments so as to enhance its protection and management. 展开更多
关键词 WETLAND ECOSYSTEM CHANGING process IMPACT factorS Shuangtaizi ESTUARY WETLAND
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The multi-factor recombination and processes superimposition model for hydrocarbon accumulation:application to the Silurian in the Tarim Basin 被引量:9
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作者 Meng Qingyang Pang Xiongqi Gao Jianbo 《Petroleum Science》 SCIE CAS CSCD 2008年第1期13-19,共7页
The multi-factor recombination and processes superimposition model for hydrocarbon accumulation is put forward in view of the hydrocarbon geological characteristics of multiple episodes of structural evolution, multip... The multi-factor recombination and processes superimposition model for hydrocarbon accumulation is put forward in view of the hydrocarbon geological characteristics of multiple episodes of structural evolution, multiple sets of source-reservoir-seal assemblage, multiple cycles of hydrocarbon accumulation and multiple episodes of readjustment and reconstruction in the complex superimposed basins in China. It is a system including theories and methods that can help to predict favorable exploration regions. According to this model, the basic discipline for hydrocarbon generation, evolution and distribution in the superimposed basins can be summarized in multi-factor recombination, processes superimposition, multiple stages of oil filling and latest stage preservation. With the Silurian of the Tarim basin as an example, based on the reconstruction of the evolution history of the four factors (paleo-anticline, source rock, regional cap rock and kinematic equilibrium belt) controlling hydrocarbon accumulation, this model was adopted to predict favorable hydrocarbon accumulation areas and favorable exploration regions following structural destruction in three stages of oil filling, to provide guidance for further exploration ofoil and gas in the Silurian of the Tarim basin. 展开更多
关键词 Multi-factor recombination processes superimposition Tarim Basin SILURIAN favorable exploration region prediction
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Landslide susceptibility assessment using the certainty factor and analytic hierarchy process 被引量:18
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作者 FAN Wen WEI Xin-sheng +1 位作者 CAO Yan-bo ZHENG Bin 《Journal of Mountain Science》 SCIE CSCD 2017年第5期906-925,共20页
A new approach combining the certainty factor(CF) and analytic hierarchy process(AHP) methods was proposed to assess landslide susceptibility in the Ziyang district, which is situated in the Qin-Ba Mountain region, Ch... A new approach combining the certainty factor(CF) and analytic hierarchy process(AHP) methods was proposed to assess landslide susceptibility in the Ziyang district, which is situated in the Qin-Ba Mountain region, China. Landslide inventory data were collected based on field investigations and remote sensing interpretations. A total of 791 landslides were identified. A total of 633 landslides were randomly selected from this data setas the training set, and the remaining landslides were used for validation as the test set. Nine factors, including the slope angle, slope aspect, slope curvature, lithology, distance to faults, distance to streams, precipitation, road network intensity degree and land use were chosen as the landslide causal factors for further susceptibility assessment. The weight of each factor and its subclass were calculated by AHP and CF methods. Landslide susceptibility was compared between the bivariate statistical method and the proposed CF-AHP method. The results indicate that the distance to streams, distance to faults and lithology are the most dominant causal factors associated with landslides. The susceptibility zonation was categorized into five classes of landslide susceptibility, i.e., very high, high, moderate, low and very low level. Lastly, the relative operating characteristics(ROC) curve was used to validate the accuracy of the new approach, and the result showed a satisfactory prediction rate of 78.3%, compared to 69.2% obtained with the landslide susceptibility index method. The results indicate that the CF-AHP combined method is more appropriate for assessing the landslide susceptibility in this area. 展开更多
关键词 Ziyang district LANDSLIDE Certainty factor Analytic hierarchy process Susceptibility assessment ARCGIS
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Factor and Cluster Analysis on the Competitiveness of Agri-food Processing Industry in China
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作者 Ling WANG 《Asian Agricultural Research》 2017年第2期1-5,共5页
This paper establishes 13 evaluation indicators for the competitiveness of agri-food processing industry,uses factor analysis to evaluate the competitiveness of agri-food processing industry in 31 provinces(cities,aut... This paper establishes 13 evaluation indicators for the competitiveness of agri-food processing industry,uses factor analysis to evaluate the competitiveness of agri-food processing industry in 31 provinces(cities,autonomous regions)of China,and does cluster analysis to divide these regions into several categories according to the difference in competitiveness,in order to understand the level of competitiveness of agri-food processing industry in China. 展开更多
关键词 Agri-food processing industry COMPETITIVENESS factor analysis Cluster analysis
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QCD factorization Drell–Yan process
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作者 周高亮 《Communications in Theoretical Physics》 SCIE CAS CSCD 2016年第2期193-203,共11页
An alternative proof of factorization theorem for Drell–Yan process that works at operator level is presented in this paper. Contributions of interactions after the hard collision for such inclusive processes are pro... An alternative proof of factorization theorem for Drell–Yan process that works at operator level is presented in this paper. Contributions of interactions after the hard collision for such inclusive processes are proved to be canceled at operator level according to the unitarity of time evolution operator. After this cancellation, there are no longer leading pinch singular surface in Glauber region in the time evolution of electromagnetic currents. Effects of soft gluons are absorbed into Wilson lines of scalar-polarized gluons. Cancelation of soft gluons is attribute to unitarity of time evolution operator and such Wilson lines. 展开更多
关键词 A Proof of factorization Theorem of Drell–Yan process at Operator Level
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Research on Knowledge Transfer Influencing Factors in Software Process Improvement
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作者 Jiangping Wan Qingjing Liu +1 位作者 Dejie Li Hongbo Xu 《Journal of Software Engineering and Applications》 2010年第2期134-140,共7页
Knowledge transfer model of software process improvement (SPI) and the conceptual framework of influencing factors are established. The model includes five elements which are knowledge of transfer, sources of knowledg... Knowledge transfer model of software process improvement (SPI) and the conceptual framework of influencing factors are established. The model includes five elements which are knowledge of transfer, sources of knowledge, recipients of knowledge, relationship of transfer parties, and the environment of transfer. The conceptual framework includes ten key factors which are ambiguity, systematism, transfer willingness, capacity of impartation, capacity of absorption, incen-tive mechanism, culture, technical support, trust and knowledge distance. The research hypothesis is put forward. Em-pirical study concludes that the trust relationship among SPI staffs has the greatest influence on knowledge transfer, and organizational incentive mechanism can produce positive effect to knowledge transfer of SPI. Finally, some sug-gestions are put forward to improve the knowledge transfer of SPI: establishing a rational incentive mechanism, exe-cuting some necessary training to transfer parties and using software benchmarking. 展开更多
关键词 SOFTWARE process IMPROVEMENT KNOWLEDGE TRANSFER Influence factorS PATTERN
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Emission factors of particulate matter, CO and CO_2 in the pyrolytic processing of typical electronic wastes 被引量:2
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作者 Liyuan Chen Chuanyang Cai +3 位作者 Shuangyu Yu Yu Liu Shu Tao Wenxin Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第7期93-101,共9页
A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes(E-wastes), including printed wiring boards(PWBs)and plastic casings. The generated particula... A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes(E-wastes), including printed wiring boards(PWBs)and plastic casings. The generated particulate matter(PM) of different particle sizes, carbon monoxide(CO) and carbon dioxide(CO_2) were determined, and the corresponding emission factors(EFs) were estimated. Finer particles with particle sizes of 0.4–2.1 μm accounted for78.9% and 89.3% of PM emitted by the pyrolytic processing of PWBs and plastic casings,respectively, and the corresponding EFs were 9.68 ± 4.81 and 18.49 ± 7.2 g/kg, respectively.The EFs of CO and CO_2 from PWBs and plastic casings were 55.9 ± 26.9 and 1182 ± 439 g/kg,and 133.6 ± 34.6 and 2827 ± 276 g/kg, respectively. Compared with other emission sources,such as coal, biomass, and traffic exhaust, the EFs of E-wastes were relatively higher,especially for PM. There were significant positive correlations(p < 0.05) of the initial contents of carbon and nitrogen in PWBs with the related EFs of PM, CO, and CO_2, while the correlations for plastic casings were insignificant. The EFs of CO of PWBs were significantly positively correlated with the corresponding EFs of PM and the parent polycyclic aromatic hydrocarbons(PAHs); however, the same result was not observed for plastic casings. 展开更多
关键词 Pyrolytic processing of electronic-wastes PARTICULATE matter CO CO2 Emission factor
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Empirical Research on Critical Success Factors of Agile Software Process Improvement
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作者 Jiangping Wan Ruoting Wang 《Journal of Software Engineering and Applications》 2010年第12期1131-1140,共10页
In this paper, we discuss agile software process improvement in P company with their description of process management in current level and analysis of problems, design the P Company success factors model in organizat... In this paper, we discuss agile software process improvement in P company with their description of process management in current level and analysis of problems, design the P Company success factors model in organizational culture, systems, products, customers, markets, leadership, technology and other key dimensions, which is verified through questionnaire in P company. In the end, we apply knowledge creation theory to analyze the open source software community with successful application of the typical agile software method, propose ten principles of knowledge creation in open source software community: Self-organizing, Code sharing, Adaptation, Usability, Sustention, Talent, Interaction, Collaboration, Happiness, and Democracy. 展开更多
关键词 AGILE Methodology SOFTWARE process Improvement Critical SUCCESS factor Knowledge CREATION Open Source SOFTWARE COMMUNITY
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鱼糜制品加工品质影响因素的研究进展
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作者 龙俊敏 刘宇 张席成 《现代食品》 2026年第1期191-193,共3页
鱼糜制品加工是水产品加工的重要分支,其加工品质会受到多种因素影响。本文对鱼糜制品加工品质影响因素进行综述,明确鱼种、储存对品质的影响,同时对漂洗等工艺及添加剂的应用进行综述,以期为鱼糜制品的品质提升提供有益参考。
关键词 鱼糜制品 加工品质 影响因素 研究进展
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天然草原区牧户草场利用行为及其演变的研究进展
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作者 董佳宇 林婧雯 史梦瑶 《草食家畜》 2026年第1期59-63,共5页
【目的】旨在研究锡林郭勒盟部分旗(县)天然草原区牧户草场利用行为及其演变历程,梳理牧户草场利用行为演变中的特点及存在问题,为未来牧户草场利用行为的研究提供思路。【方法】通过2025年多次实地考察及查阅资料等方式,对锡林郭勒盟... 【目的】旨在研究锡林郭勒盟部分旗(县)天然草原区牧户草场利用行为及其演变历程,梳理牧户草场利用行为演变中的特点及存在问题,为未来牧户草场利用行为的研究提供思路。【方法】通过2025年多次实地考察及查阅资料等方式,对锡林郭勒盟部分旗(县)天然草原区牧户草场利用行为进行研究。【结果】研究发现,锡林郭勒盟部分旗(县)137户牧户草场利用行为的类型主要有3种,在不同的时期牧户草场利用行为略有不同,同时牧户草场利用行为的演变受多种因素的影响。【结论】经过详细梳理、深入探讨和借鉴,提出牧户草场利用行为未来可能的研究方向及改善牧户草场利用行为的对策建议。 展开更多
关键词 天然草原区 牧户草场利用行为 演变历程 驱动因素
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基于层次分析法的柜类定制家具设计评价指标体系分析
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作者 郭红果 《鞋类工艺与设计》 2026年第1期144-146,共3页
本文通过层次分析法(AHP)分析消费者对私人定制家具的购买评价因素,通过问卷调查,提出影响消费者购买柜类定制家具的主要因素,包括“使用界面”“储物与展示功能”“板材和五金”“表面装饰与拓展功能”和“外观和设计”等5个方面,再通... 本文通过层次分析法(AHP)分析消费者对私人定制家具的购买评价因素,通过问卷调查,提出影响消费者购买柜类定制家具的主要因素,包括“使用界面”“储物与展示功能”“板材和五金”“表面装饰与拓展功能”和“外观和设计”等5个方面,再通过3个评价标准对权重进行排序。根据对数据的分析,总结出消费者对柜类定制家具购买的因素并进行排序。研究结果可作为定制家具制造商发展业务的参考依据,提升企业定制家具的卖点以及准确获取消费者购买动机。 展开更多
关键词 定制家具 层次分析法(AHP) 评价因素 评价标准
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源汇系统:研究关注热点和发展趋势
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作者 朱筱敏 刘强虎 +1 位作者 谈明轩 陈贺贺 《古地理学报》 北大核心 2026年第1期25-43,共19页
源汇系统是指从剥蚀地貌中剥蚀产生、经搬运体系输送、最终在沉积地貌中沉积下来的完整沉积物剥蚀—搬运—沉积过程,其研究不仅有助于完整认识地球表层动力学过程及其演化,而且能为沉积矿产勘探开发提供地质基础和预测性模型。在分析源... 源汇系统是指从剥蚀地貌中剥蚀产生、经搬运体系输送、最终在沉积地貌中沉积下来的完整沉积物剥蚀—搬运—沉积过程,其研究不仅有助于完整认识地球表层动力学过程及其演化,而且能为沉积矿产勘探开发提供地质基础和预测性模型。在分析源汇系统研究历史的基础上,认为当今关注热点包括整合视角下的现代源汇系统研究、深时源汇系统与古地理重建、源汇过程表征与地貌—沉积演化耦合模拟和源汇系统理论的能源地质应用;指出在源汇系统分类和主要类型特征、物源区特征和供源作用、搬运过程和路径系统信号传播、沉积过程(砂体分散体系)和控制因素、源汇系统要素定量表征(BQART模型)、源汇系统与砂体预测等方面取得了显著进展,最后讨论了源汇系统未来研究应关注的搬运过程和路径系统信号传播、源汇系统要素定量表征与砂体预测等主要研究方向。 展开更多
关键词 源汇系统 物源区及供源作用 沉积路径系统 沉积过程与控制因素 砂体预测 发展趋势
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化浊散结除痹颗粒的制备工艺优化研究
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作者 王美玲 彭斯伟 +7 位作者 张英杰 肖艳 杨瑞芳 陈冰燕 杨帆 陈鹏 苏友新 郭洁梅 《中药新药与临床药理》 北大核心 2026年第2期332-342,共11页
目的优化化浊散结除痹颗粒的制备工艺。方法采用超高效液相色谱(UPLC)建立化浊散结除痹颗粒复方多成分含量测定方法,以新异落新妇苷、异落新妇苷、新落新妇苷、落新妇苷、盐酸小檗碱的转移率、出膏率为评价指标,通过单因素试验结合正交... 目的优化化浊散结除痹颗粒的制备工艺。方法采用超高效液相色谱(UPLC)建立化浊散结除痹颗粒复方多成分含量测定方法,以新异落新妇苷、异落新妇苷、新落新妇苷、落新妇苷、盐酸小檗碱的转移率、出膏率为评价指标,通过单因素试验结合正交试验考察提取时间、加水量、提取次数对化浊散结除痹颗粒提取工艺的影响;采用休止角测定、辅料筛选及工艺验证优选化浊散结除痹颗粒的成型工艺,并通过中试试验验证化浊散结除痹颗粒的工艺。结果化浊散结除痹颗粒优选的制备工艺为:化浊散结除痹方各饮片加热回流提取2次,第一次加12倍水,提取1.5 h;第二次加12倍水,提取1.0 h;合并药液,减压浓缩至相对密度1.07~1.08 g·cm^(3)的浓缩液(65~75℃);加入5%麦芽糊精,喷雾干燥(进风温度175~185℃、出风温度90~100℃);加入干膏粉质量的0.3%二氧化硅、0.1%硬脂酸镁及麦芽糊精适量,混合均匀后干法制粒,整粒分装。中试试验制备的3批化浊散结除痹颗粒各项评价指标良好,且批次间差异小。结论优选的化浊散结除痹颗粒制备工艺稳定、可靠,可为该颗粒剂的工艺标准化奠定研究基础。 展开更多
关键词 化浊散结除痹颗粒 超高效液相色谱 正交试验 制备工艺优化 单因素试验 工艺标准化
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城市更新背景下建筑垃圾资源化产业发展影响因素分析
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作者 范云翠 宫煜彦 《建材技术与应用》 2026年第1期115-120,共6页
在快速推进城市更新改造过程中,建筑垃圾产生量日益剧增,进行建筑垃圾资源化可以减少环境污染,实现城市可持续发展。为推动建筑垃圾资源化产业发展,从经济、技术、社会、环境和治理五个方面分析城市更新对建筑垃圾资源化产业发展的影响... 在快速推进城市更新改造过程中,建筑垃圾产生量日益剧增,进行建筑垃圾资源化可以减少环境污染,实现城市可持续发展。为推动建筑垃圾资源化产业发展,从经济、技术、社会、环境和治理五个方面分析城市更新对建筑垃圾资源化产业发展的影响,运用层次分析法(AHP)识别产业发展影响因素之间的层次关系及影响力。结果表明:政策扶持和激励措施、再生产品市场需求、城市更新投资规模、再生产品示范项目和资源化技术水平是关键影响因素。最后,结合分析结果提出相应的对策建议。 展开更多
关键词 城市更新 建筑垃圾资源化 影响因素 层次分析法
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边缘场景下计及驾驶员认知处理过程的驾驶风险场模型构建
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作者 周彬 杨志峰 +2 位作者 张峻宁 董元发 彭巍 《中国机械工程》 北大核心 2026年第1期223-232,242,共11页
人-车共驾过程中,驾驶员的情绪变化会导致认知变化,进而改变车辆风险场,为此构建了一种考虑驾驶员认知-情绪状态的人因风险场模型。首先通过驾驶模拟器实验收集并分析车辆行驶数据和驾驶员生理信号;随后标定人因风险场中的驾驶员因子;... 人-车共驾过程中,驾驶员的情绪变化会导致认知变化,进而改变车辆风险场,为此构建了一种考虑驾驶员认知-情绪状态的人因风险场模型。首先通过驾驶模拟器实验收集并分析车辆行驶数据和驾驶员生理信号;随后标定人因风险场中的驾驶员因子;最后通过六自由度驾驶模拟器采集实验数据并对人因风险场风险指标与多传统风险指标进行对比。人因风险场模型在边缘场景下能更有效和稳定评估不同情绪驾驶员的行车风险。 展开更多
关键词 行车风险场 边缘场景 认知处理过程 人因行为场
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羟乙磺酸哌柏西利片制备工艺优化研究
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作者 周敏 王静 +1 位作者 王文萱 魏蔚 《山东化工》 2026年第3期10-14,共5页
为了建立并优化羟乙磺酸哌柏西利片的制备工艺,采用对比实验及单因素试验,比较元素差异对处方制备的影响。以中间体的流动性、可填充性和溶出行为等为指标进行考察。结果显示,最优处方为填充剂m(微晶纤维素)∶m(乳糖)为2∶1,崩解剂的用... 为了建立并优化羟乙磺酸哌柏西利片的制备工艺,采用对比实验及单因素试验,比较元素差异对处方制备的影响。以中间体的流动性、可填充性和溶出行为等为指标进行考察。结果显示,最优处方为填充剂m(微晶纤维素)∶m(乳糖)为2∶1,崩解剂的用量为6%,硬脂酸镁作为润滑剂的用量为2%。采用干法制粒的工艺,以送料速度6 r/min,压辊转速4 r/min,压辊压力为30 kg/cm 3,一级整粒筛为2.0 mm,二级整粒筛为1.0 mm,建立了一套完整的羟乙磺酸哌柏西利片制备工艺。最终获得了羟乙磺酸哌柏西利片最优处方与制备工艺,符合质量与稳定要求,可在生产上推广。 展开更多
关键词 羟乙磺酸哌柏西利片 单因素 处方优化 工艺改进
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