In this paper,a probe method for nonlinear programming wiht equality and inequality is given. Its iterative directions at an arbitrary point x can be obtained through solving a liear system. The terminate conditions a...In this paper,a probe method for nonlinear programming wiht equality and inequality is given. Its iterative directions at an arbitrary point x can be obtained through solving a liear system. The terminate conditions and choices of the parameters are given. The global convergence of the method is proved. Further more,some well known gradient projection type algorithms [1-15] and new gradient projection type algorithms from the linear system are given in this paper.展开更多
The authors presented a new measuring method of the soil thermal conductivity,the probe method,which is designed and made based on the theory of line heat source. This method is used to measure thermal conductivity of...The authors presented a new measuring method of the soil thermal conductivity,the probe method,which is designed and made based on the theory of line heat source. This method is used to measure thermal conductivity of coarse sand,fine sand and silty clay in different water contents. The results that measured by the probe method are well consistent with those of QTM-D_2. The soil thermal conductivity increases in different levels with the increase of the water content. Compared the soil thermal conductivity measured by the probe method in laboratory with in-situ experiment,it shows that the measuring gap gradually increases with the increase of the depth. The reason is that the in-situ measuring thermal conductivity can reflect the actual situation of the soil mass.展开更多
In this paper, we present the theory and numerical implementation for a 2-D thermal inhomogeneity through the dynamical probe method. The main idea of the dynamical probe method is to construct an indicator function a...In this paper, we present the theory and numerical implementation for a 2-D thermal inhomogeneity through the dynamical probe method. The main idea of the dynamical probe method is to construct an indicator function associated with some probe such that when the probe touch the boundary of the inclusion the indicator function will blow up. From this property, we can get the shape of the inclusion. We will give the numerical reconstruction algorithm to identify the inclusion from the simulated Neumann-to-Dirichlet map.展开更多
Recent developments in micro- and nano-satellites have attracted the interest of the research community worldwide. Many colleges and corporations have launched their satellites in space. Meanwhile, the space flexible ...Recent developments in micro- and nano-satellites have attracted the interest of the research community worldwide. Many colleges and corporations have launched their satellites in space. Meanwhile, the space flexible probe-cone docking system for micro- and nano-satellites has become an attractive topic. In this paper, a dynamic model of a space flexible probe-cone dock- ing system, in which the flexible beam technology is applied, is built based on the Kane method. The curves of impact force versus time are obtained by the Lagrange model, the Kane model, and the experimental method. The Lagrange model was presented in the reference and verified by both finite element simulation and experiment. The results of the three methods show good agreements on the condition that the beam flexibility and the initial relative velocity change. It is worth mentioning that the introduction of vectorial mechanics and analytical mechanics in the Kane method leads to a large reduction of differential operations and makes the modeling process much easier than that of the Lagrange method. Moreover, the influences of the beam flexibility and the initial relative velocity are discussed. It is concluded that the initial relative velocity of space docking operation should be controlled to a certain value in order to protect the docking system.展开更多
中药化学生物学(traditional Chinese medicine chemical biology,TCMCB)作为21世纪中医药现代化进程中形成的重要学科方向,其研究模式通过整合现代化学与生物学等技术手段,构建了具有鲜明中医药特色的研究体系。该学科方向立足中医药理...中药化学生物学(traditional Chinese medicine chemical biology,TCMCB)作为21世纪中医药现代化进程中形成的重要学科方向,其研究模式通过整合现代化学与生物学等技术手段,构建了具有鲜明中医药特色的研究体系。该学科方向立足中医药理论,聚焦以中药活性成分为分子探针的研究策略,通过识别作用靶点,系统解析中药成分调控的复杂生物学机制。当前,TCMCB主要通过有机合成化学实现中药活性分子结构优化与探针制备,借助化学蛋白质组学完成靶点识别,结合结构生物学解析分子互作模式,并整合分子药理学与临床医学验证其生物学调控机制,形成了多维度揭示中药药效物质基础及其药理作用规律的方法学体系。研究成果为中药复杂而独特的作用机制解析提供了分子层面的科学证据,进而有效推动了中药质量标准制定、中医临床精准用药以及中医药的现代化与国际化推广。值得强调的是,TCMCB不仅推动了传统中医药理论的现代科学诠释,更通过发现新型生物靶点与作用机制为现代生命科学提供了独特的观察视角,特别是在复杂疾病系统调控机制研究方面展现出显著优势。该文通过系统梳理TCMCB领域近十年的研究概况,重点探讨其方法论对中医药现代化研究的推动作用,同时TCMCB也将着力构建具有自主知识产权的技术体系,持续为中医药理论创新发展提供原动力,并为生命科学研究和新药研发开辟可借鉴的范式。展开更多
文摘In this paper,a probe method for nonlinear programming wiht equality and inequality is given. Its iterative directions at an arbitrary point x can be obtained through solving a liear system. The terminate conditions and choices of the parameters are given. The global convergence of the method is proved. Further more,some well known gradient projection type algorithms [1-15] and new gradient projection type algorithms from the linear system are given in this paper.
基金Supported by Project of National Natural Science Foundation of China(No.41372239)
文摘The authors presented a new measuring method of the soil thermal conductivity,the probe method,which is designed and made based on the theory of line heat source. This method is used to measure thermal conductivity of coarse sand,fine sand and silty clay in different water contents. The results that measured by the probe method are well consistent with those of QTM-D_2. The soil thermal conductivity increases in different levels with the increase of the water content. Compared the soil thermal conductivity measured by the probe method in laboratory with in-situ experiment,it shows that the measuring gap gradually increases with the increase of the depth. The reason is that the in-situ measuring thermal conductivity can reflect the actual situation of the soil mass.
基金supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) under the grant number KRF-2006-214-C00007
文摘In this paper, we present the theory and numerical implementation for a 2-D thermal inhomogeneity through the dynamical probe method. The main idea of the dynamical probe method is to construct an indicator function associated with some probe such that when the probe touch the boundary of the inclusion the indicator function will blow up. From this property, we can get the shape of the inclusion. We will give the numerical reconstruction algorithm to identify the inclusion from the simulated Neumann-to-Dirichlet map.
基金supported in part by the National Natural Science Foundation of China (Nos. 91216201, 51205403)
文摘Recent developments in micro- and nano-satellites have attracted the interest of the research community worldwide. Many colleges and corporations have launched their satellites in space. Meanwhile, the space flexible probe-cone docking system for micro- and nano-satellites has become an attractive topic. In this paper, a dynamic model of a space flexible probe-cone dock- ing system, in which the flexible beam technology is applied, is built based on the Kane method. The curves of impact force versus time are obtained by the Lagrange model, the Kane model, and the experimental method. The Lagrange model was presented in the reference and verified by both finite element simulation and experiment. The results of the three methods show good agreements on the condition that the beam flexibility and the initial relative velocity change. It is worth mentioning that the introduction of vectorial mechanics and analytical mechanics in the Kane method leads to a large reduction of differential operations and makes the modeling process much easier than that of the Lagrange method. Moreover, the influences of the beam flexibility and the initial relative velocity are discussed. It is concluded that the initial relative velocity of space docking operation should be controlled to a certain value in order to protect the docking system.
文摘中药化学生物学(traditional Chinese medicine chemical biology,TCMCB)作为21世纪中医药现代化进程中形成的重要学科方向,其研究模式通过整合现代化学与生物学等技术手段,构建了具有鲜明中医药特色的研究体系。该学科方向立足中医药理论,聚焦以中药活性成分为分子探针的研究策略,通过识别作用靶点,系统解析中药成分调控的复杂生物学机制。当前,TCMCB主要通过有机合成化学实现中药活性分子结构优化与探针制备,借助化学蛋白质组学完成靶点识别,结合结构生物学解析分子互作模式,并整合分子药理学与临床医学验证其生物学调控机制,形成了多维度揭示中药药效物质基础及其药理作用规律的方法学体系。研究成果为中药复杂而独特的作用机制解析提供了分子层面的科学证据,进而有效推动了中药质量标准制定、中医临床精准用药以及中医药的现代化与国际化推广。值得强调的是,TCMCB不仅推动了传统中医药理论的现代科学诠释,更通过发现新型生物靶点与作用机制为现代生命科学提供了独特的观察视角,特别是在复杂疾病系统调控机制研究方面展现出显著优势。该文通过系统梳理TCMCB领域近十年的研究概况,重点探讨其方法论对中医药现代化研究的推动作用,同时TCMCB也将着力构建具有自主知识产权的技术体系,持续为中医药理论创新发展提供原动力,并为生命科学研究和新药研发开辟可借鉴的范式。
