With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Techn...With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.展开更多
Flux-coated brazing and soldering material is a type of material-saving and emission-reducing composite material in recent years,which is the representative product of the development of brazing and soldering technolo...Flux-coated brazing and soldering material is a type of material-saving and emission-reducing composite material in recent years,which is the representative product of the development of brazing and soldering technology,which is highly concerned by welding researchers worldwide.This work mainly reviewed the research reports on the design,preparation technology,and application of flux-coated brazing and soldering materials,put forward the shortcomings of current research,and proposed the future research directions mainly focusing on the standards,the synergistic reaction mechanism between flux and metals,the alloying,and the morphology of flux-coated brazing and soldering materials in order to provide reference information and theoretical guidance for related research and technological development in the field of welding.展开更多
In recent years,superhard coatings have emerged as a focal point in metal material research due to their innovative design strategies and exceptional mechanical properties.They are widely utilized in industries such a...In recent years,superhard coatings have emerged as a focal point in metal material research due to their innovative design strategies and exceptional mechanical properties.They are widely utilized in industries such as shielding,oil extraction,and coal mining.However,in practical applications,tools often suffer from wear,fractures,plastic deformation,and other types of failure,directly impacting machining efficiency,costs,and product quality.To mitigate these challenges,the selection of appropriate tool materials and preparation methods is critical to ensure sustained production efficiency.Therefore,it is essential to identify and develop coating materials with superior performance.Recent advancements in superhard coatings are reviewed comprehensively;preparation methods are discussed for superhard tools;diamond coatings,diamond-like carbon coatings,cubic boron nitride coatings and graphite carbon nitride coatings are examined specifically.It analyzes their microstructures,phase transformation processes,mechanical properties,and formation mechanisms,while also evaluating properties such as wear resistance,corrosion resistance,and high hardness.The applicability of existing theoretical models is verified and new frameworks for future superhard coating designs are proposed.Moreover,the current research limitations in tool coatings are identified and directions for future research and development are proposed.展开更多
Cu-Zn-Al slurry catalysts were prepared using a complete liquid-phase preparation technology under different heat treatment atmospheres.The catalysts were characterized using X-ray diffraction,X-ray photoelectron spec...Cu-Zn-Al slurry catalysts were prepared using a complete liquid-phase preparation technology under different heat treatment atmospheres.The catalysts were characterized using X-ray diffraction,X-ray photoelectron spectroscope,and N2 adsorption-desorption.Their application in the single-step synthesis of dimethyl ether from syngas was also investigated.The results indicate that the type of heat treatment atmosphere has an influence on the Cu species and the Cu0/Cu＋ ratio on the catalyst surface.Moreover,the final Cu/Zn ratio on the catalyst surface is mainly dependent on the composition and reaction environment of the catalyst and less on the type of heat treatment atmosphere.The prepared catalysts can suppress sintering of active sites at high temperatures,and the type of heat treatment atmosphere mainly affects the capability of the catalyst for methanol synthesis.The catalysts perform best using N2 as the heat treatment atmosphere.展开更多
Coated capillary columns were prepared by sol-gel technology and used in the separation of basic proteins with capillary zone electrophoresis. The results indicated that a significant decrease in protein adsorption wa...Coated capillary columns were prepared by sol-gel technology and used in the separation of basic proteins with capillary zone electrophoresis. The results indicated that a significant decrease in protein adsorption was obtained and EOF was also diminished to zero in the pH range of 3-10.展开更多
[Objectives]To optimize the extraction and preparation technology of Wuwei Xiaoke granules.[Methods]Taking the extraction rate of extract as the scoring standard,the water extraction technology was optimized by orthog...[Objectives]To optimize the extraction and preparation technology of Wuwei Xiaoke granules.[Methods]Taking the extraction rate of extract as the scoring standard,the water extraction technology was optimized by orthogonal test.The influence of the proportion of pharmaceutical excipients on the molding conditions of Wuwei Xiaoke granules was investigated using granule molding rate,solubility,moisture,granularity,water-soluble extract and microorganism examination as evaluation indicators,and the optimal molding technology was optimized.[Results]The extraction technology was soaking in water for 0.5 h and heat extraction twice for 1 h each time:adding 10 times the amount of water in the first time,and adding 8 times the amount of water in the second time.The best molding technology was:extract density 1.13-1.16(55-60℃),extract:soluble starch=1:2,and 0.15%stevioside.[Conclusions]The water extraction technology and granule molding technology optimized by orthogonal test are reliable and stable,with good granular characteristics,easy oral administration and good solubility,which can maximize the comprehensive quality of Wuwei Xiaoke granules,and provide an effective reference for the preparation and production of Wuwei Xiaoke granules.展开更多
In pharmaceutical preparation technology teaching process, teachers should attach importance to strengthen the basic knowledge and practical skills teaching, make it master modern pharmaceutical knowledge, experimenta...In pharmaceutical preparation technology teaching process, teachers should attach importance to strengthen the basic knowledge and practical skills teaching, make it master modern pharmaceutical knowledge, experimental technology, modern preparation technology, etc., to participate in pharmaceutical preparation technology related production technology operation and management and cultivate skilled and innovative professionals. Pharmaceutical preparation technology is one of the core courses of pharmacy major in secondary vocational schools. The problems existing in the teaching process in the past: moral education penetration is not paid enough attention to students lack of learning motivation and students ideology is not good. The infiltration of moral education is the related need of talent training and professional ethics is inevitable and it can implement the concept of moral education. Under the leadership of the school, professional teachers should strengthen cooperation, determine the goal of moral education in the curriculum, develop school-based moral education teaching materials, give full play to the exemplary role of teachers, knowledge teaching permeates moral education, practice teaching permeates moral education, improve students professional quality and better cultivate professional skills with both political integrity and ability.展开更多
Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniqu...Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniques is crucial for the manufacture of key components,including blades,discs,shafts,and gears.However,machining THSAs pose significant challenges,including high cutting forces and temperatures,which lead to rapid tool wear,reduced efficiency,and compromised surface integrity.This review thoroughly explores the current landscape and future directions of cutting techniques for THSAs in aero-engines.It examines the principles,mechanisms,and benefits of energy-assisted cutting technologies like laser-assisted machining and cryogenic cooling.The review assesses various tool preparation methods,their effects on tool performance,and strategies for precise shape and surface integrity control.It also outlines intelligent monitoring technologies for machining process status,covering aspects such as tool wear,surface roughness,and chatter,contributing to intelligent manufacturing.Additionally,it highlights emerging trends and potential future developments,including multi-energy assisted cutting mechanisms,advanced cutting tools,and collaborative control of structure shape and surface integrity,alongside intelligent monitoring software and hardware.This review serves as a reference for achieving efficient and high-quality manufacturing of THSAs in aero-engines.展开更多
The catalyst layers(CLs) electrode is the key component of the membrane electrode assembly(MEA) in proton exchange membrane fuel cells(PEMFCs). Conventional electrodes for PEMFCs are composed of carbon-supported, iono...The catalyst layers(CLs) electrode is the key component of the membrane electrode assembly(MEA) in proton exchange membrane fuel cells(PEMFCs). Conventional electrodes for PEMFCs are composed of carbon-supported, ionomer, and Pt nanoparticles, all immersed together and sprayed with a micron-level thickness of CLs. They have a performance trade-off where increasing the Pt loading leads to higher performance of abundant triple-phase boundary areas but increases the electrode cost. Major challenges must be overcome before realizing its wide commercialization. Literature research revealed that it is impossible to achieve performance and durability targets with only high-performance catalysts, so the controllable design of CLs architecture in MEAs for PEMFCs must now be the top priority to meet industry goals. From this perspective, a 3D ordered electrode circumvents this issue with a support-free architecture and ultrathin thickness while reducing noble metal Pt loadings. Herein, we discuss the motivation in-depth and summarize the necessary CLs structural features for designing ultralow Pt loading electrodes. Critical issues that remain in progress for 3D ordered CLs must be studied and characterized. Furthermore, approaches for 3D ordered CLs architecture electrode development, involving material design, structure optimization, preparation technology, and characterization techniques, are summarized and are expected to be next-generation CLs for PEMFCs. Finally, the review concludes with perspectives on possible research directions of CL architecture to address the significant challenges in the future.展开更多
In recent years,high-entropy alloys(HEAs)have become prominent metallic materials due to their unique design strategies and excellent mechanical properties.The HEAs-inherent high-entropy,lattice-distortion,sluggish-di...In recent years,high-entropy alloys(HEAs)have become prominent metallic materials due to their unique design strategies and excellent mechanical properties.The HEAs-inherent high-entropy,lattice-distortion,sluggish-diffusion,and cocktail effects make HEAs maintain high strength,oxidation resistance,corrosion resistance,wear resistance,and other excellent comprehensive properties,showing stronger competitiveness relative to traditional alloys.Refractory high-entropy alloys(RHEAs)are considered as a new kind of high-temperature materials with great application prospects due to their excellent mechanical properties and have the potential to replace nickel-based superalloy as the next generation of high-temperature materials.We reviewed the research status and preparation methods of RHEAs in recent years,including the metallurgical smelting,powder metallurgy,magnetron sputtering,and additive manufacturing technologies.The microstructure and phase-transformation process of RHEAs were analyzed.The mechan-ical properties and main strengthening and toughening mechanisms of RHEAs,such as solid-solution strengthening,precipitation strengthening,and the transformation-induced plasticity(TRIP),were discussed,and the deformation mechanism of RHEAs was revealed.The properties of RHEAs,including high strength,oxidation resistance,corrosion and wear resistance were reviewed.RHEAs will meet the huge market demand in the engineering materials field,but there are still many challenges,such as the tradeoff between high strength and high ductility,structural design,and performance optimization of RHEAs with brittle BCC structures.We believe that this combination of knowledge may shape the future of RHEAs and break through the mutually exclusive conundrum of high strength and high toughness for RHEAs.展开更多
Since perovskite solar cells appeared in 2009, its simple preparation process, high photoelectric conversion efficiency and the characteristic of low cost in preparation process let it become the hot spot of both at-h...Since perovskite solar cells appeared in 2009, its simple preparation process, high photoelectric conversion efficiency and the characteristic of low cost in preparation process let it become the hot spot of both at-home and abroad. Owing to the constant efforts of scientists, the conversion efficiency of perovskite solar cells is more than 20% now. Perovskite solar cells are mainly composed of conductive glass, electron transport layer and hole transport layer, perovskite layer and electrode parts. This paper will briefly introduce the working principle and working pro- cess about the electron transport layer of perovskite solar cells. The paper focuses on aspects such as material types （e.g., inorganic electron transport materials, organic small molecule electron transport materials, surface modified electron transport materials and doped electron transport materials）, preparation technology of electron transport layer, the effects of electron transport layer on the photo- voltaic performance of the devices, and the electron transport layer in the future research.展开更多
A sintering technology for preparing porous materials from sea bottom sediments was developed for use in water purification. The purpose of the present study was to develop methods for converting the sea bottom sedime...A sintering technology for preparing porous materials from sea bottom sediments was developed for use in water purification. The purpose of the present study was to develop methods for converting the sea bottom sediments dredged from Ago Bay into value-added recycled products. The sintered products fabricated at 400℃ were found to be very effective adsorbents for the removal of heavy metals.展开更多
Uniform circinate aggregates of sheet ZnO nanoparticles with a specific surface area of 24 m^2·g^-1 were prepared by the direct precipitation method.The circinate aggregates were hexagonal ZnO,with the wall thick...Uniform circinate aggregates of sheet ZnO nanoparticles with a specific surface area of 24 m^2·g^-1 were prepared by the direct precipitation method.The circinate aggregates were hexagonal ZnO,with the wall thickness ranging from 0.5 to 1 μm and the diameter ranging from 5 to 10 μm.The backs of the circinate aggregates were regularly arranged by numerous sheet ZnO nanoparticles with a thickness of 30-80 nm and a diameter of 300-400 nm.The precursors were aggregates of sheet Zn5（CO3）2（OH）6 nanoparticles,which were decomposed into ZnO by calcining in air in the range of 200-285°C,and the ZnO retained the similar special structure.The C2H5OH content had a significant effect on the formation of sheet ZnO.The centripetal force,the Van der Waals force,and the hydrogen bond were deduced as the driving forces of the formation of circinate.展开更多
[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Usin...[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable.展开更多
Objective:To prepare cationic liposome nanoparticles loaded with survivin-siRNA and Cnidium monnieri based on the ability of liposomes to contain both water-soluble and lipid soluble components.Methods:The preparation...Objective:To prepare cationic liposome nanoparticles loaded with survivin-siRNA and Cnidium monnieri based on the ability of liposomes to contain both water-soluble and lipid soluble components.Methods:The preparation technology of Osthol cationic liposomes was optimized by orthogonal test with membrane material ratio,drug lipid ratio,ultrasonic time and steaming temperature as factors.The volume ratio of HA-siRNA to protamine and the ratio of HA-siRNA protamine complex to liposome were investigated by control variable method with potential and particle size as indexes.The particle size and zeta potential were measured by potentiometric particle size analyzer,and the shape was observed by transmission electron microscope;The absorbance of different concentrations of FAM-Survivin-siRNA standard solution was measured by microplate analyzer,and the entrapment efficiency of cationic liposomes loaded with FAM-Survivin-siRNA and osthole was calculated.Results:The optimum preparation conditions of osthole loaded cationic liposomes were as follows:the ratio of membrane to material was 3:1,the ratio of drug to lipid was 1:5,the steaming temperature was 30℃,the ultrasonic time was 70 min,and the encapsulation efficiency was 78.34%.The optimum preparation conditions of osthole loaded cationic liposomes loaded FAM-Survivin-siRNA were as follows:the volume ratio of Survivin-siRNA to protamine was 1:1,Protamine complex 25μg.Add 50μL cationic liposomes.The particle size is 132.3±0.2nm,zeta potential is 43.15±0.05mv,and its shape is irregular round;According to the standard curve,the entrapment efficiency of cationic liposome nanoparticles co loaded with Survivin-siRNA and osthole was 81.34±0.041%.Conclusion:The prepared cationic liposome nanoparticles loaded with Survivin-siRNA and osthole have good encapsulation efficiency,particle size and zeta potential.展开更多
By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it ...By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it was found that the sodium subtilis lipopeptide was more efficient.展开更多
With the continuous development of drug delivery technology,natural polyphenol self-assembled drug delivery systems(DDS)have become a research focus due to their unique advantages.Polyphenols can not only serve as dru...With the continuous development of drug delivery technology,natural polyphenol self-assembled drug delivery systems(DDS)have become a research focus due to their unique advantages.Polyphenols can not only serve as drugs themselves but also as components of self-assembled drug delivery systems,broadening their application in the field of drug delivery.This article reviews the mechanisms of interactions between polyphenols and other molecules,and analyzes the process of constructing drug delivery systems with polyphenols.At the same time,it deeply explores the multiple functions of polyphenol self-assembled complexes in drug delivery,such as enhancing drug efficacy,achieving precise targeted delivery,and overcoming biological barriers,highlighting their great potential in enhancing drug efficacy and reducing side effects.In addition,several advanced characterization and preparation techniques are introduced and discussed,which will help to deeply understand and evaluate the structure and performance of polyphenol selfassembled delivery systems,promoting their further development.Finally,the challenges and future intelligent manufacturing strategies of polyphenol self-assembled complexes are summarized.展开更多
Industry 4.0 and the pandemic have caused recent changes in innovative development,economic situations,and restrictions in various companies and regions of the world,with new stricter legislation related to working co...Industry 4.0 and the pandemic have caused recent changes in innovative development,economic situations,and restrictions in various companies and regions of the world,with new stricter legislation related to working conditions,hygiene standards,and health requirements.New technologies are a challenge to the transformation of problem companies and regions,as they often significantly impact economic development.Technological emissions,growing information on dementia among young people,cyber risks,and the risks of so-called advanced technologies(e.g.,bio-and nanotechnologies,Industry 4.0 tech)may raise societal concerns about technological progress.This study is part of our long-term research into technological innovation in different companies and regions.Its primary goal is to methodically emphasize the importance and role of the systemic management of technological innovation in companies and regions and analytically compare the innovation success of differently developed regions from a global perspective1.This research deals with an important aspect of technology management,namely,the processes of technological identification and the protection of related intellectual property(IP).The primary research question is:How has technological development been distributed across different regions over the last two decades?We hypothesize that Asian countries are increasingly moving away from Europe and North America in terms of technological innovation,other forms of technological IP protection,and overall access to innovation,while the focus is on the development of three non-patent forms of technological innovation protection:industrial designs,trademarks,and utility models.The results of our study reveal a significant difference in the approach to technological innovation management and the form of IP protection between so-called advanced and problem companies and regions.This study was conducted between 2018 and 2022.展开更多
文摘With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.
基金Henan Province Central Guiding Local Science and Technology Development Fund Project(Z20231811002)。
文摘Flux-coated brazing and soldering material is a type of material-saving and emission-reducing composite material in recent years,which is the representative product of the development of brazing and soldering technology,which is highly concerned by welding researchers worldwide.This work mainly reviewed the research reports on the design,preparation technology,and application of flux-coated brazing and soldering materials,put forward the shortcomings of current research,and proposed the future research directions mainly focusing on the standards,the synergistic reaction mechanism between flux and metals,the alloying,and the morphology of flux-coated brazing and soldering materials in order to provide reference information and theoretical guidance for related research and technological development in the field of welding.
基金financially supported by the National Natural Science Foundation of China(No.52475347)the National Program of Foreign Experts of China(No.G2023026003L)+3 种基金the High-end Foreign Experts Introduction Project of Henan Province,China(No.HNGD2025026)Project supported by the Program for the Top Young Talents of Henan Province,China,Project(No.242102521057)sponsored by the International Science and Technology Cooperation Project of Henan Province,China,and projects supported by China Postdoctoral Foundation(No.2023M740475)Henan Provincial Science and Technology R&D Joint Fund(Industry)(No.225101610002).
文摘In recent years,superhard coatings have emerged as a focal point in metal material research due to their innovative design strategies and exceptional mechanical properties.They are widely utilized in industries such as shielding,oil extraction,and coal mining.However,in practical applications,tools often suffer from wear,fractures,plastic deformation,and other types of failure,directly impacting machining efficiency,costs,and product quality.To mitigate these challenges,the selection of appropriate tool materials and preparation methods is critical to ensure sustained production efficiency.Therefore,it is essential to identify and develop coating materials with superior performance.Recent advancements in superhard coatings are reviewed comprehensively;preparation methods are discussed for superhard tools;diamond coatings,diamond-like carbon coatings,cubic boron nitride coatings and graphite carbon nitride coatings are examined specifically.It analyzes their microstructures,phase transformation processes,mechanical properties,and formation mechanisms,while also evaluating properties such as wear resistance,corrosion resistance,and high hardness.The applicability of existing theoretical models is verified and new frameworks for future superhard coating designs are proposed.Moreover,the current research limitations in tool coatings are identified and directions for future research and development are proposed.
基金supported by the National Natural Science Foundation of China(No.20706039)the National Basic Research Program(973 Program) of China (No.2005CB221204)+1 种基金the Program for the Top Young Academic Leaders of Higher Learning Institutions of Shanxi of China in 2010the Young Scientific and the Technical Fund of Shanxi of China (No.2006021010)
文摘Cu-Zn-Al slurry catalysts were prepared using a complete liquid-phase preparation technology under different heat treatment atmospheres.The catalysts were characterized using X-ray diffraction,X-ray photoelectron spectroscope,and N2 adsorption-desorption.Their application in the single-step synthesis of dimethyl ether from syngas was also investigated.The results indicate that the type of heat treatment atmosphere has an influence on the Cu species and the Cu0/Cu＋ ratio on the catalyst surface.Moreover,the final Cu/Zn ratio on the catalyst surface is mainly dependent on the composition and reaction environment of the catalyst and less on the type of heat treatment atmosphere.The prepared catalysts can suppress sintering of active sites at high temperatures,and the type of heat treatment atmosphere mainly affects the capability of the catalyst for methanol synthesis.The catalysts perform best using N2 as the heat treatment atmosphere.
文摘Coated capillary columns were prepared by sol-gel technology and used in the separation of basic proteins with capillary zone electrophoresis. The results indicated that a significant decrease in protein adsorption was obtained and EOF was also diminished to zero in the pH range of 3-10.
基金Supported by Self-funded Research Project of Traditional Chinese Medicine Administration of Guangxi Zhuang Autonomous Region(GXZYZ20210313)National TCM Characteristic Technology Inheritance Talent Training Program(GZYYBRJF[2014]39).
文摘[Objectives]To optimize the extraction and preparation technology of Wuwei Xiaoke granules.[Methods]Taking the extraction rate of extract as the scoring standard,the water extraction technology was optimized by orthogonal test.The influence of the proportion of pharmaceutical excipients on the molding conditions of Wuwei Xiaoke granules was investigated using granule molding rate,solubility,moisture,granularity,water-soluble extract and microorganism examination as evaluation indicators,and the optimal molding technology was optimized.[Results]The extraction technology was soaking in water for 0.5 h and heat extraction twice for 1 h each time:adding 10 times the amount of water in the first time,and adding 8 times the amount of water in the second time.The best molding technology was:extract density 1.13-1.16(55-60℃),extract:soluble starch=1:2,and 0.15%stevioside.[Conclusions]The water extraction technology and granule molding technology optimized by orthogonal test are reliable and stable,with good granular characteristics,easy oral administration and good solubility,which can maximize the comprehensive quality of Wuwei Xiaoke granules,and provide an effective reference for the preparation and production of Wuwei Xiaoke granules.
文摘In pharmaceutical preparation technology teaching process, teachers should attach importance to strengthen the basic knowledge and practical skills teaching, make it master modern pharmaceutical knowledge, experimental technology, modern preparation technology, etc., to participate in pharmaceutical preparation technology related production technology operation and management and cultivate skilled and innovative professionals. Pharmaceutical preparation technology is one of the core courses of pharmacy major in secondary vocational schools. The problems existing in the teaching process in the past: moral education penetration is not paid enough attention to students lack of learning motivation and students ideology is not good. The infiltration of moral education is the related need of talent training and professional ethics is inevitable and it can implement the concept of moral education. Under the leadership of the school, professional teachers should strengthen cooperation, determine the goal of moral education in the curriculum, develop school-based moral education teaching materials, give full play to the exemplary role of teachers, knowledge teaching permeates moral education, practice teaching permeates moral education, improve students professional quality and better cultivate professional skills with both political integrity and ability.
基金National Natural Science Foundation of China(Nos.92160301,92060203,52175415,and 52205475)Science Center for Gas Turbine Project(No.P2023-B-IV-003-001)+1 种基金Natural Science Foundation of Jiangsu Province(No.BK20210295)Fundamental Research Funds for the Central Universities(Nos.NS2023028 and NG2024015)。
文摘Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniques is crucial for the manufacture of key components,including blades,discs,shafts,and gears.However,machining THSAs pose significant challenges,including high cutting forces and temperatures,which lead to rapid tool wear,reduced efficiency,and compromised surface integrity.This review thoroughly explores the current landscape and future directions of cutting techniques for THSAs in aero-engines.It examines the principles,mechanisms,and benefits of energy-assisted cutting technologies like laser-assisted machining and cryogenic cooling.The review assesses various tool preparation methods,their effects on tool performance,and strategies for precise shape and surface integrity control.It also outlines intelligent monitoring technologies for machining process status,covering aspects such as tool wear,surface roughness,and chatter,contributing to intelligent manufacturing.Additionally,it highlights emerging trends and potential future developments,including multi-energy assisted cutting mechanisms,advanced cutting tools,and collaborative control of structure shape and surface integrity,alongside intelligent monitoring software and hardware.This review serves as a reference for achieving efficient and high-quality manufacturing of THSAs in aero-engines.
基金funded by the Natural Science Foundation of Shandong Province, China (ZR2023MB049)the China Postdoctoral Science Foundation (2020M670483)the Science Foundation of Weifang University (2023BS11)。
文摘The catalyst layers(CLs) electrode is the key component of the membrane electrode assembly(MEA) in proton exchange membrane fuel cells(PEMFCs). Conventional electrodes for PEMFCs are composed of carbon-supported, ionomer, and Pt nanoparticles, all immersed together and sprayed with a micron-level thickness of CLs. They have a performance trade-off where increasing the Pt loading leads to higher performance of abundant triple-phase boundary areas but increases the electrode cost. Major challenges must be overcome before realizing its wide commercialization. Literature research revealed that it is impossible to achieve performance and durability targets with only high-performance catalysts, so the controllable design of CLs architecture in MEAs for PEMFCs must now be the top priority to meet industry goals. From this perspective, a 3D ordered electrode circumvents this issue with a support-free architecture and ultrathin thickness while reducing noble metal Pt loadings. Herein, we discuss the motivation in-depth and summarize the necessary CLs structural features for designing ultralow Pt loading electrodes. Critical issues that remain in progress for 3D ordered CLs must be studied and characterized. Furthermore, approaches for 3D ordered CLs architecture electrode development, involving material design, structure optimization, preparation technology, and characterization techniques, are summarized and are expected to be next-generation CLs for PEMFCs. Finally, the review concludes with perspectives on possible research directions of CL architecture to address the significant challenges in the future.
文摘In recent years,high-entropy alloys(HEAs)have become prominent metallic materials due to their unique design strategies and excellent mechanical properties.The HEAs-inherent high-entropy,lattice-distortion,sluggish-diffusion,and cocktail effects make HEAs maintain high strength,oxidation resistance,corrosion resistance,wear resistance,and other excellent comprehensive properties,showing stronger competitiveness relative to traditional alloys.Refractory high-entropy alloys(RHEAs)are considered as a new kind of high-temperature materials with great application prospects due to their excellent mechanical properties and have the potential to replace nickel-based superalloy as the next generation of high-temperature materials.We reviewed the research status and preparation methods of RHEAs in recent years,including the metallurgical smelting,powder metallurgy,magnetron sputtering,and additive manufacturing technologies.The microstructure and phase-transformation process of RHEAs were analyzed.The mechan-ical properties and main strengthening and toughening mechanisms of RHEAs,such as solid-solution strengthening,precipitation strengthening,and the transformation-induced plasticity(TRIP),were discussed,and the deformation mechanism of RHEAs was revealed.The properties of RHEAs,including high strength,oxidation resistance,corrosion and wear resistance were reviewed.RHEAs will meet the huge market demand in the engineering materials field,but there are still many challenges,such as the tradeoff between high strength and high ductility,structural design,and performance optimization of RHEAs with brittle BCC structures.We believe that this combination of knowledge may shape the future of RHEAs and break through the mutually exclusive conundrum of high strength and high toughness for RHEAs.
基金financially supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.SZBF201437)A Funding of Jiangsu Innovation Program for Graduate Education(No.SJLX16_0429)
文摘Since perovskite solar cells appeared in 2009, its simple preparation process, high photoelectric conversion efficiency and the characteristic of low cost in preparation process let it become the hot spot of both at-home and abroad. Owing to the constant efforts of scientists, the conversion efficiency of perovskite solar cells is more than 20% now. Perovskite solar cells are mainly composed of conductive glass, electron transport layer and hole transport layer, perovskite layer and electrode parts. This paper will briefly introduce the working principle and working pro- cess about the electron transport layer of perovskite solar cells. The paper focuses on aspects such as material types （e.g., inorganic electron transport materials, organic small molecule electron transport materials, surface modified electron transport materials and doped electron transport materials）, preparation technology of electron transport layer, the effects of electron transport layer on the photo- voltaic performance of the devices, and the electron transport layer in the future research.
文摘A sintering technology for preparing porous materials from sea bottom sediments was developed for use in water purification. The purpose of the present study was to develop methods for converting the sea bottom sediments dredged from Ago Bay into value-added recycled products. The sintered products fabricated at 400℃ were found to be very effective adsorbents for the removal of heavy metals.
基金supported by the National Natural Science Foundation of China(No.50374021).
文摘Uniform circinate aggregates of sheet ZnO nanoparticles with a specific surface area of 24 m^2·g^-1 were prepared by the direct precipitation method.The circinate aggregates were hexagonal ZnO,with the wall thickness ranging from 0.5 to 1 μm and the diameter ranging from 5 to 10 μm.The backs of the circinate aggregates were regularly arranged by numerous sheet ZnO nanoparticles with a thickness of 30-80 nm and a diameter of 300-400 nm.The precursors were aggregates of sheet Zn5（CO3）2（OH）6 nanoparticles,which were decomposed into ZnO by calcining in air in the range of 200-285°C,and the ZnO retained the similar special structure.The C2H5OH content had a significant effect on the formation of sheet ZnO.The centripetal force,the Van der Waals force,and the hydrogen bond were deduced as the driving forces of the formation of circinate.
基金Supported by Innovation and Entrepreneurship Training Program Project of Southwest Minzu University(S202210656134)Project of Sichuan Department of Science and Technology(2022NSFSC1437)Project of Sichuan Administration of Traditional Chinese Medicine(2021MS121).
文摘[Objectives] To explore the optimal process for preparing hydroxypropyl tetrahydropyrantriol liposomes. [Methods] A refractive index method was used to determine the content of hydroxypropyl tetrahydropyrantriol. Using particle size distribution and encapsulation rate as evaluation indicators, the effects of hydration time, ratio of organic phase to aqueous phase, granulation method, as well as thin film dispersion and reverse evaporation methods on liposomes preparation were investigated, and the optimal preparation method was selected. Single factor experiments were used to screen the drug phospholipid ratio, ultrasound time, and phospholipid cholesterol ratio, and the preparation process was optimized through orthogonal experiments. [Results] The optimal process of preparing hydroxypropyl tetrahydropyrantriol liposomes was as below: 1 : 10 of drug phospholipid ratio, 6 min of ultrasound time, 4 : 1 of phospholipid cholesterol ratio, (60.94%±7.24%) of entrapment efficiency, (86.44±6.08) nm of particle size, (0.195±0.077) of PDI. [Conclusions] The optimal preparation process of hydroxypropyl tetrahydropyrantriol liposomes selected by orthogonal experiment could effectively improve the encapsulation efficiency of hydroxypropyl tetrahydropyranotriol and reduce particle size. Moreover, the method was stable and reliable.
基金Harbin Applied Technology Research and Development Project(No.2016RAQXJ197)。
文摘Objective:To prepare cationic liposome nanoparticles loaded with survivin-siRNA and Cnidium monnieri based on the ability of liposomes to contain both water-soluble and lipid soluble components.Methods:The preparation technology of Osthol cationic liposomes was optimized by orthogonal test with membrane material ratio,drug lipid ratio,ultrasonic time and steaming temperature as factors.The volume ratio of HA-siRNA to protamine and the ratio of HA-siRNA protamine complex to liposome were investigated by control variable method with potential and particle size as indexes.The particle size and zeta potential were measured by potentiometric particle size analyzer,and the shape was observed by transmission electron microscope;The absorbance of different concentrations of FAM-Survivin-siRNA standard solution was measured by microplate analyzer,and the entrapment efficiency of cationic liposomes loaded with FAM-Survivin-siRNA and osthole was calculated.Results:The optimum preparation conditions of osthole loaded cationic liposomes were as follows:the ratio of membrane to material was 3:1,the ratio of drug to lipid was 1:5,the steaming temperature was 30℃,the ultrasonic time was 70 min,and the encapsulation efficiency was 78.34%.The optimum preparation conditions of osthole loaded cationic liposomes loaded FAM-Survivin-siRNA were as follows:the volume ratio of Survivin-siRNA to protamine was 1:1,Protamine complex 25μg.Add 50μL cationic liposomes.The particle size is 132.3±0.2nm,zeta potential is 43.15±0.05mv,and its shape is irregular round;According to the standard curve,the entrapment efficiency of cationic liposome nanoparticles co loaded with Survivin-siRNA and osthole was 81.34±0.041%.Conclusion:The prepared cationic liposome nanoparticles loaded with Survivin-siRNA and osthole have good encapsulation efficiency,particle size and zeta potential.
文摘By adjusting the order of adding oil phase and water phase,it was found that the emulsion prepared by d-phase method was more stable. Compared with the traditional anionic surfactant potassium cetaceanol phosphate,it was found that the sodium subtilis lipopeptide was more efficient.
基金supported by grants from the National Natural Science Foundation of China(Nos.82304871 and 81973493)Natural Science Foundation of Sichuan Province(No.2024NSFSC1846)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202209).
文摘With the continuous development of drug delivery technology,natural polyphenol self-assembled drug delivery systems(DDS)have become a research focus due to their unique advantages.Polyphenols can not only serve as drugs themselves but also as components of self-assembled drug delivery systems,broadening their application in the field of drug delivery.This article reviews the mechanisms of interactions between polyphenols and other molecules,and analyzes the process of constructing drug delivery systems with polyphenols.At the same time,it deeply explores the multiple functions of polyphenol self-assembled complexes in drug delivery,such as enhancing drug efficacy,achieving precise targeted delivery,and overcoming biological barriers,highlighting their great potential in enhancing drug efficacy and reducing side effects.In addition,several advanced characterization and preparation techniques are introduced and discussed,which will help to deeply understand and evaluate the structure and performance of polyphenol selfassembled delivery systems,promoting their further development.Finally,the challenges and future intelligent manufacturing strategies of polyphenol self-assembled complexes are summarized.
文摘Industry 4.0 and the pandemic have caused recent changes in innovative development,economic situations,and restrictions in various companies and regions of the world,with new stricter legislation related to working conditions,hygiene standards,and health requirements.New technologies are a challenge to the transformation of problem companies and regions,as they often significantly impact economic development.Technological emissions,growing information on dementia among young people,cyber risks,and the risks of so-called advanced technologies(e.g.,bio-and nanotechnologies,Industry 4.0 tech)may raise societal concerns about technological progress.This study is part of our long-term research into technological innovation in different companies and regions.Its primary goal is to methodically emphasize the importance and role of the systemic management of technological innovation in companies and regions and analytically compare the innovation success of differently developed regions from a global perspective1.This research deals with an important aspect of technology management,namely,the processes of technological identification and the protection of related intellectual property(IP).The primary research question is:How has technological development been distributed across different regions over the last two decades?We hypothesize that Asian countries are increasingly moving away from Europe and North America in terms of technological innovation,other forms of technological IP protection,and overall access to innovation,while the focus is on the development of three non-patent forms of technological innovation protection:industrial designs,trademarks,and utility models.The results of our study reveal a significant difference in the approach to technological innovation management and the form of IP protection between so-called advanced and problem companies and regions.This study was conducted between 2018 and 2022.
