为了探究微针辅助经皮给药的促透效果,本试验通过自制盐酸雷莫司琼贴片与微针联合应用,考察透皮贴片经微针辅助给药后的体外渗透性能及其体内药动学。采用Valia-Chien双室渗透池进行离体豚鼠皮肤渗透试验,Beagle犬进行药动学试验。离体...为了探究微针辅助经皮给药的促透效果,本试验通过自制盐酸雷莫司琼贴片与微针联合应用,考察透皮贴片经微针辅助给药后的体外渗透性能及其体内药动学。采用Valia-Chien双室渗透池进行离体豚鼠皮肤渗透试验,Beagle犬进行药动学试验。离体皮肤渗透试验结果显示,微针辅助给药试验组药物的稳态渗透速率、48 h累积渗透量分别是仅贴片给药对照组的1.68倍和1.80倍,渗透时滞也显著低于仅贴片给药对照组(P<0.01)。Beagle犬药动学试验结果显示,经微针预处理试验组的c_(max)和AUC_(0→t)分别为仅贴片给药对照组的4.8倍和4.6倍,具显著差异(P<0.01),t_(max)亦较对照组显著缩短(P<0.01,6.2 h vs 30.7 h)。离体皮肤渗透试验和在体皮肤药动学试验评价结果显示,微针辅助给药在促进药物吸收与缩短渗透时滞方面均有显著效果。展开更多
测量了20 ke V质子穿过倾斜角为+1?的聚碳酸酯微孔膜后,出射粒子的位置分布、相对穿透率以及电荷纯度随时间的演化.实验发现,能量电荷比E/q≈10~1k V的质子穿过绝缘纳米微孔的物理机理与E/q≈10~0k V和E/q≈10~2k V区域离子有显著不同....测量了20 ke V质子穿过倾斜角为+1?的聚碳酸酯微孔膜后,出射粒子的位置分布、相对穿透率以及电荷纯度随时间的演化.实验发现,能量电荷比E/q≈10~1k V的质子穿过绝缘纳米微孔的物理机理与E/q≈10~0k V和E/q≈10~2k V区域离子有显著不同.对于E/q≈10~1k V的质子穿过绝缘纳米微孔,存在一段相当长的导向建立之前(导向前)的过程,在该时期内出射质子及氢原子的特性和导向建立后的特性有很大差异.在导向前的演化过程中,我们可以观察到出射质子的峰位逐渐向孔轴向附近转移;出射氢原子由束流方向的尖峰以及孔轴向的主峰构成,峰位角保持基本不变且尖峰逐渐消失.这一过程的主要机理为微孔内表面以下的多次随机二体碰撞和近表面镜面反射两种传输方式逐步向电荷斑约束下的"导向效应"过渡的过程.对E/q≈10~1k V区间离子"导向前过程"的完整观测,使得对低能向中能过渡区间离子穿过绝缘微孔膜物理机制和图像有更深入和完整的认识,有助于约10 ke V离子微束的精确控制和应用.展开更多
Dragonfly is Password Authenticated Key Exchange protocol that uses a shared session key to authenticate parties based on pre-shared secret password. It was claimed that this protocol was secure against off-line dicti...Dragonfly is Password Authenticated Key Exchange protocol that uses a shared session key to authenticate parties based on pre-shared secret password. It was claimed that this protocol was secure against off-line dictionary attack, but a new research has proved its vulnerability to off-line dictionary attack and proving step was applied by using “Patched Protocol” which was based on public key validation. Unfortunately, this step caused a raise in the computation cost, which made this protocol less appealing than its competitors. We proposed an alternate enhancement to keep this protocol secure without any extra computation cost that was known as “Enhanced Dragonfly”. This solution based on two-pre-shared secret passwords instead of one and the rounds between parties had compressed into two rounds instead of four. We prove that the enhanced-Dragonfly protocol is secure against off-line dictionary attacks by analyzing its security properties using the Scyther tool. A simulation was developed to measure the execution time of the enhanced protocol, which was found to be much less than the execution time of patched Dragonfly. The off-line dictionary attack time is consumed for few days if the dictionary size is 10,000. According to this, the use of the enhanced Dragonfly is more efficient than the patched Dragonfly.展开更多
文摘为了探究微针辅助经皮给药的促透效果,本试验通过自制盐酸雷莫司琼贴片与微针联合应用,考察透皮贴片经微针辅助给药后的体外渗透性能及其体内药动学。采用Valia-Chien双室渗透池进行离体豚鼠皮肤渗透试验,Beagle犬进行药动学试验。离体皮肤渗透试验结果显示,微针辅助给药试验组药物的稳态渗透速率、48 h累积渗透量分别是仅贴片给药对照组的1.68倍和1.80倍,渗透时滞也显著低于仅贴片给药对照组(P<0.01)。Beagle犬药动学试验结果显示,经微针预处理试验组的c_(max)和AUC_(0→t)分别为仅贴片给药对照组的4.8倍和4.6倍,具显著差异(P<0.01),t_(max)亦较对照组显著缩短(P<0.01,6.2 h vs 30.7 h)。离体皮肤渗透试验和在体皮肤药动学试验评价结果显示,微针辅助给药在促进药物吸收与缩短渗透时滞方面均有显著效果。
文摘测量了20 ke V质子穿过倾斜角为+1?的聚碳酸酯微孔膜后,出射粒子的位置分布、相对穿透率以及电荷纯度随时间的演化.实验发现,能量电荷比E/q≈10~1k V的质子穿过绝缘纳米微孔的物理机理与E/q≈10~0k V和E/q≈10~2k V区域离子有显著不同.对于E/q≈10~1k V的质子穿过绝缘纳米微孔,存在一段相当长的导向建立之前(导向前)的过程,在该时期内出射质子及氢原子的特性和导向建立后的特性有很大差异.在导向前的演化过程中,我们可以观察到出射质子的峰位逐渐向孔轴向附近转移;出射氢原子由束流方向的尖峰以及孔轴向的主峰构成,峰位角保持基本不变且尖峰逐渐消失.这一过程的主要机理为微孔内表面以下的多次随机二体碰撞和近表面镜面反射两种传输方式逐步向电荷斑约束下的"导向效应"过渡的过程.对E/q≈10~1k V区间离子"导向前过程"的完整观测,使得对低能向中能过渡区间离子穿过绝缘微孔膜物理机制和图像有更深入和完整的认识,有助于约10 ke V离子微束的精确控制和应用.
文摘Dragonfly is Password Authenticated Key Exchange protocol that uses a shared session key to authenticate parties based on pre-shared secret password. It was claimed that this protocol was secure against off-line dictionary attack, but a new research has proved its vulnerability to off-line dictionary attack and proving step was applied by using “Patched Protocol” which was based on public key validation. Unfortunately, this step caused a raise in the computation cost, which made this protocol less appealing than its competitors. We proposed an alternate enhancement to keep this protocol secure without any extra computation cost that was known as “Enhanced Dragonfly”. This solution based on two-pre-shared secret passwords instead of one and the rounds between parties had compressed into two rounds instead of four. We prove that the enhanced-Dragonfly protocol is secure against off-line dictionary attacks by analyzing its security properties using the Scyther tool. A simulation was developed to measure the execution time of the enhanced protocol, which was found to be much less than the execution time of patched Dragonfly. The off-line dictionary attack time is consumed for few days if the dictionary size is 10,000. According to this, the use of the enhanced Dragonfly is more efficient than the patched Dragonfly.
