Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a c...With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.展开更多
Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development ...Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development process of Machine Translation during 1930s-1970 s could help researchers gain new insights through restudying old material.展开更多
In the present article we review behavioral and neurophysiological studies on face processing in adults and in early development. From the existing empirical and theoretical literature we derive three aspects that dis...In the present article we review behavioral and neurophysiological studies on face processing in adults and in early development. From the existing empirical and theoretical literature we derive three aspects that distinguish face processing from the processing of other visual object categories. Each of these aspects is discussed from a developmental perspective. First, faces are recognized and represented at the individual level rather than at the basic level. Second, humans typically acquire extensive expertise in individuating faces from early on in development. And third, more than other objects, faces are processed holistically. There is a quantitative difference in the amount of visual experience for faces and other object categories in that the amount of expertise typically acquired for faces is greater than that for other object categories. In addition, we discuss possible qualitative differences in experience for faces and objects. For instance, there is evidence for a sensitive period in infancy for building up a holistic face representation and for perceptual narrowing for faces of one＇s own species and race. We conclude our literature review with questions for future research, for instance, regarding the exact relationship between behavioral and neuronal markers of face processing across development.展开更多
China＇s reform and opening-up policy has brought the country a great development opportunity. The high-speed growth of the economy not only led China to a period of industrialization, urbanization, informatization an...China＇s reform and opening-up policy has brought the country a great development opportunity. The high-speed growth of the economy not only led China to a period of industrialization, urbanization, informatization and agricultural modernization, but also exacerbated the situation of the urban–rural dual structure. Based on the review of current studies, we first used the analytic hierarchy process（AHP） method to evaluate the urban–rural development and transformation level by population transformation index, land transformation index, industrial transformation index and social transformation index between 1996 and 2012 around the Bohai Rim Region. Then, based on the results of each index, we used the exploratory spatial data analysis（ESDA） method to investigate the spatial autocorrelation of the change in the urban–rural development transformation index during the 16-year period using Global Moran＇s I index and Local Moran＇s I index. Finally, we investigated the mechanism of change of the urban–rural development transformation index at county level, summarizing five main factors：（1） the radiation from the surrounding big cities,（2） the acceleration of the urbanization process,（3） the upgrading of the industrial structure,（4） the publishing and implementation of a macro development strategy and regional policy, and（5） natural factors such as topology.展开更多
This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on ...This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.展开更多
he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure wit...he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure with the inclusion of each new technology and discipline. Therefore, step by step, each design verification phase definition in the flow contains important phase transition measurements or approval tolerances that ensure the simplicity and continuity of vehicle development processes. In addition, classification of design verification stages within the framework of this study or evaluation in two classes (static and dynamic) is a new approach, but it is a synthesis with the analysis of the new product development process. The vehicle’s basic structure, which constitutes the ergonomic and functional requirements of the vehicle in a static environment, takes into account the dynamic environment variables with crash or accident tests. Increasing new technology adaptations in the automotive industry have changed the new product development process that performs this function structurally and created the concept of design verification under consecutive or simultaneous process simplicity. From the autonomous driving to the use of alternative energy, possible accident scenarios and design verification phase transitions in the integration of parts and systems of the newly developed vehicle create a new structure that models and directs the lean product development process especially in the automotive industry in the coming days. In the lean product development process that takes place in the automotive industry, the design verification transition steps or the approval-control analysis of the development stages, which form a new and effective approach, are re-modeling the entire flow. Therefore, successful execution of design verification steps used in the control of new interdisciplinary product development phase transitions provides value creation.?Within the scope of this study, the effectiveness of the static and dynamic design verification steps, which are carried out in 5 global automotive companies included in the research, which constitute the stage transitions of the new product development process, has been measured. Apart from the design verification transition stages, the process variables that differ among the automotive companies involved in the research are excluded from the scope of this study. In other words, in field researches in the automotive industry, new vehicle design steps or basic engineering steps in the new product development process steps, while creating independent fixed variables, interdisciplinary collaborations, static and dynamic design verification transition stages they perform, or their sequence in the basic flow, is accepted as a dependent variable. Therefore, in the study, the positive effect of the automotive companies that included the static and dynamic design verification phase transition approvals in the lean product development process was investigated. Under the comparative analysis structure of the research, the effect of automotive companies, which accept international vehicle specifications as static design verification input, on market performance has been examined in depth. The detailed depth in the comparison analysis conducted under the second field studies of the study is due to the prediction of dynamic design verification stages to provide a high impact on the market performance, according to the static verification analysis. The new product development stages of the dependent variables were fixed and the flow-oriented?“effect”?of the independent variables in the basic process influenced by the design verification activities was analyzed under the new automotive industry company comparisons. In addition, the impact of the automotive design activities that make up the comparison analysis of the research on the scope of the lean product development stage and its effect on the basic process flow has been demonstrated competition-oriented. Therefore, sub-variables, options, criteria, results, which form a defined comparison problem, create basic test values that affect the problem.展开更多
The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has th...The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_(2)CsSb photocathode preparation systems and detailed preparation process of K_(2)CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_(2)CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.展开更多
Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surp...Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surplus,and deep processing industry lag. It is suggested that we should guide the initial processing layout of betel nut according to local conditions,and carry out overall deep processing planning of betel nut; support betel nut deep processing plant in the main producing areas,establish betel nut initial processing and deep processing serial production line,and develop new betel nut product; build betel nut production,processing,transport and marketing information database and market information early warning mechanism,and improve betel nut processing information service platform to timely provide information services and continuously develop betel nut industry.展开更多
The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-s...The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-scale stirred tank bioreactor (STR) which are labor and resource intensive and time-consuming. Here we demonstrate a strategy for rapid and robust cell culture process development by evaluating and implementing the use of a new HTP disposable micro bioreactor (MBR) called AMBRTM system (Advanced Microscale Bioreactor) that has the capabilities for automated sampling, feed addition, pH, dissolved oxygen (DO), gassing and agitation controls. In these studies the performance of two monoclonal antibody (MAb) producing cell lines (MAb1 and MAb2) was evaluated both in the AMBR system and 3-L STR. We demonstrated that cell culture performance (growth and viability, production titer and product quality) were similar in both vessel systems. Furthermore, process control and feed optimization were demonstrated in an additional cell line (MAb3) in the disposable MBR and its performance confirmed at STR scale. The results indicate that the AMBR system can be used to streamline the process development effort and facilitate a rapid and robust cell culture process development effort for MAb programs in a HTP manner.展开更多
This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of...This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region （or adsorption constant） are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations （PDEs） is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.展开更多
Traditional trade routes that penetrate the natural barrier of the Himalayas are critical for connecting major Chinese and South Asian markets.Research on these trade routes can contribute significantly to facilitatin...Traditional trade routes that penetrate the natural barrier of the Himalayas are critical for connecting major Chinese and South Asian markets.Research on these trade routes can contribute significantly to facilitating the construction of the South Asian Corridor and enhancing trans-Himalayan connectivity.Combining historical literature,field surveys,and geographic information system(GIS)techniques,this study examined the spatial distribution characteristics and evolution process of the routes,focusing on transverse valleys of the Himalayan arc.The key findings were as follows.First,there are 21 traditional trade routes traversing the Himalayan region:six Sino-Nepalese routes,four Sino-Bhutanese routes,and eleven Sino-Indian routes.Second,the evolution of traditional trade routes has entailed five distinct phases:an incipient period(pre-7th century),formation(7th century-842 AD),development(842-1959),decline(1959-1962)and recovery(1962-present).Third,the incipient and formative developmental phases were prompted by the spread of Buddhism and the exchange of goods.The stability of local governments in Tibet and Central China and favourable border trade policies along with Britain’s colonial expansion and commercial interests stimulated further development of traditional trade routes.However,India’s strategic miscalculation and“Forward Policy”instigated the decline phase,while the demands of regional cooperation and development are currently the key drivers of the restoration and construction phase.Finally,to shelve disputes,promote cooperation and development,and enhance political mutual trust,governments should recover and construct traditional trade routes by replanning and constructing border trade markets,expanding border trade,developing pilgrimage and tourism,and strengthening cross-border cooperative resear h under global climate change.展开更多
The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise co...The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise compliance with it. On the other side, Model Driven Development (MDD) has been proved as a quite successful paradigm in general-purpose computing. This was the motivation for exploiting the benefits of MDD in the industrial automation domain. With the emerging IEC 61131 specification that defines an object-oriented (OO) extension to the function block model, there will be a push to the industry to better exploit the benefits of MDD in automation systems development. This work discusses possible alternatives to integrate the current but also the emerging specification of IEC 61131 in the model driven development process of automation systems. IEC 61499, UML and SysML are considered as possible alternatives to allow the developer to work in higher layers of abstraction than the one supported by IEC 61131 and to more effectively move from requirement specifications into the implementation model of the system.展开更多
Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substant...Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.展开更多
In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countr...In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countries is introduced.According to characteristics of soil environment and practice of soil environment management in China,the relevant suggestions are discussed,thereby further perfecting construction work of soil environmental quality standards in China.展开更多
Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on th...Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is designed and developed. The design principles for IP-PDPM are described. The system architecture and functions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.展开更多
Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting ec...Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting economic development and helping farmers to get out of poverty in Guangxi. But there is almost nothing to do with the processing and utilization. Taking the route of processing and utilization is an inevitable trend of development of Longtan pearl plum industry with the increase of the planting area and yield year by year. In this paper, based on the analysis of edible value of Longtan pearl plum, the development direction of processing and utilization of Longtan pearl plum was expounded, and some suggestions on the problems existing in the processing and utilization were put forward to provide reference for the processing and utilization of Longtan pearl plum.展开更多
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金express their gratitude to the Higher Institution Centre of Excellence (HICoE) fund under the project code (JPT.S(BPKI)2000/016/018/015JId.4(21)/2022002HICOE)Universiti Tenaga Nasional (UNITEN) for funding the research through the (J510050002–IC–6 BOLDREFRESH2025)Akaun Amanah Industri Bekalan Elektrik (AAIBE) Chair of Renewable Energy grant,and NEC Energy Transition Grant (202203003ETG)。
文摘With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.
文摘Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development process of Machine Translation during 1930s-1970 s could help researchers gain new insights through restudying old material.
文摘In the present article we review behavioral and neurophysiological studies on face processing in adults and in early development. From the existing empirical and theoretical literature we derive three aspects that distinguish face processing from the processing of other visual object categories. Each of these aspects is discussed from a developmental perspective. First, faces are recognized and represented at the individual level rather than at the basic level. Second, humans typically acquire extensive expertise in individuating faces from early on in development. And third, more than other objects, faces are processed holistically. There is a quantitative difference in the amount of visual experience for faces and other object categories in that the amount of expertise typically acquired for faces is greater than that for other object categories. In addition, we discuss possible qualitative differences in experience for faces and objects. For instance, there is evidence for a sensitive period in infancy for building up a holistic face representation and for perceptual narrowing for faces of one＇s own species and race. We conclude our literature review with questions for future research, for instance, regarding the exact relationship between behavioral and neuronal markers of face processing across development.
基金National Natural Science Foundation of China,No.41130748No.41471143
文摘China＇s reform and opening-up policy has brought the country a great development opportunity. The high-speed growth of the economy not only led China to a period of industrialization, urbanization, informatization and agricultural modernization, but also exacerbated the situation of the urban–rural dual structure. Based on the review of current studies, we first used the analytic hierarchy process（AHP） method to evaluate the urban–rural development and transformation level by population transformation index, land transformation index, industrial transformation index and social transformation index between 1996 and 2012 around the Bohai Rim Region. Then, based on the results of each index, we used the exploratory spatial data analysis（ESDA） method to investigate the spatial autocorrelation of the change in the urban–rural development transformation index during the 16-year period using Global Moran＇s I index and Local Moran＇s I index. Finally, we investigated the mechanism of change of the urban–rural development transformation index at county level, summarizing five main factors：（1） the radiation from the surrounding big cities,（2） the acceleration of the urbanization process,（3） the upgrading of the industrial structure,（4） the publishing and implementation of a macro development strategy and regional policy, and（5） natural factors such as topology.
基金the National Natural Science foundation of China! (59995440)
文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.
文摘he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure with the inclusion of each new technology and discipline. Therefore, step by step, each design verification phase definition in the flow contains important phase transition measurements or approval tolerances that ensure the simplicity and continuity of vehicle development processes. In addition, classification of design verification stages within the framework of this study or evaluation in two classes (static and dynamic) is a new approach, but it is a synthesis with the analysis of the new product development process. The vehicle’s basic structure, which constitutes the ergonomic and functional requirements of the vehicle in a static environment, takes into account the dynamic environment variables with crash or accident tests. Increasing new technology adaptations in the automotive industry have changed the new product development process that performs this function structurally and created the concept of design verification under consecutive or simultaneous process simplicity. From the autonomous driving to the use of alternative energy, possible accident scenarios and design verification phase transitions in the integration of parts and systems of the newly developed vehicle create a new structure that models and directs the lean product development process especially in the automotive industry in the coming days. In the lean product development process that takes place in the automotive industry, the design verification transition steps or the approval-control analysis of the development stages, which form a new and effective approach, are re-modeling the entire flow. Therefore, successful execution of design verification steps used in the control of new interdisciplinary product development phase transitions provides value creation.?Within the scope of this study, the effectiveness of the static and dynamic design verification steps, which are carried out in 5 global automotive companies included in the research, which constitute the stage transitions of the new product development process, has been measured. Apart from the design verification transition stages, the process variables that differ among the automotive companies involved in the research are excluded from the scope of this study. In other words, in field researches in the automotive industry, new vehicle design steps or basic engineering steps in the new product development process steps, while creating independent fixed variables, interdisciplinary collaborations, static and dynamic design verification transition stages they perform, or their sequence in the basic flow, is accepted as a dependent variable. Therefore, in the study, the positive effect of the automotive companies that included the static and dynamic design verification phase transition approvals in the lean product development process was investigated. Under the comparative analysis structure of the research, the effect of automotive companies, which accept international vehicle specifications as static design verification input, on market performance has been examined in depth. The detailed depth in the comparison analysis conducted under the second field studies of the study is due to the prediction of dynamic design verification stages to provide a high impact on the market performance, according to the static verification analysis. The new product development stages of the dependent variables were fixed and the flow-oriented?“effect”?of the independent variables in the basic process influenced by the design verification activities was analyzed under the new automotive industry company comparisons. In addition, the impact of the automotive design activities that make up the comparison analysis of the research on the scope of the lean product development stage and its effect on the basic process flow has been demonstrated competition-oriented. Therefore, sub-variables, options, criteria, results, which form a defined comparison problem, create basic test values that affect the problem.
文摘The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_(2)CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_(2)CsSb photocathode preparation systems and detailed preparation process of K_(2)CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_(2)CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.
基金Supported by Special Project for Research,Development,Demonstration and Extension of Applied Technology in Hainan Province(ZDXM2014101)
文摘Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surplus,and deep processing industry lag. It is suggested that we should guide the initial processing layout of betel nut according to local conditions,and carry out overall deep processing planning of betel nut; support betel nut deep processing plant in the main producing areas,establish betel nut initial processing and deep processing serial production line,and develop new betel nut product; build betel nut production,processing,transport and marketing information database and market information early warning mechanism,and improve betel nut processing information service platform to timely provide information services and continuously develop betel nut industry.
文摘The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-scale stirred tank bioreactor (STR) which are labor and resource intensive and time-consuming. Here we demonstrate a strategy for rapid and robust cell culture process development by evaluating and implementing the use of a new HTP disposable micro bioreactor (MBR) called AMBRTM system (Advanced Microscale Bioreactor) that has the capabilities for automated sampling, feed addition, pH, dissolved oxygen (DO), gassing and agitation controls. In these studies the performance of two monoclonal antibody (MAb) producing cell lines (MAb1 and MAb2) was evaluated both in the AMBR system and 3-L STR. We demonstrated that cell culture performance (growth and viability, production titer and product quality) were similar in both vessel systems. Furthermore, process control and feed optimization were demonstrated in an additional cell line (MAb3) in the disposable MBR and its performance confirmed at STR scale. The results indicate that the AMBR system can be used to streamline the process development effort and facilitate a rapid and robust cell culture process development effort for MAb programs in a HTP manner.
基金the Basic Research Program of the Korea Science & Engineering Foundation (KoSEF, No. R01-2006-000-10786-0).
文摘This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region （or adsorption constant） are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations （PDEs） is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.
基金The Second Tibetan Plateau Scientific Expedition and Research Program,No.2019QZKK0603Strategic Priority Research Program of Chinese Academy of Sciences,No.XDA20040201National Natural Science Foundation of China,No.41761144081。
文摘Traditional trade routes that penetrate the natural barrier of the Himalayas are critical for connecting major Chinese and South Asian markets.Research on these trade routes can contribute significantly to facilitating the construction of the South Asian Corridor and enhancing trans-Himalayan connectivity.Combining historical literature,field surveys,and geographic information system(GIS)techniques,this study examined the spatial distribution characteristics and evolution process of the routes,focusing on transverse valleys of the Himalayan arc.The key findings were as follows.First,there are 21 traditional trade routes traversing the Himalayan region:six Sino-Nepalese routes,four Sino-Bhutanese routes,and eleven Sino-Indian routes.Second,the evolution of traditional trade routes has entailed five distinct phases:an incipient period(pre-7th century),formation(7th century-842 AD),development(842-1959),decline(1959-1962)and recovery(1962-present).Third,the incipient and formative developmental phases were prompted by the spread of Buddhism and the exchange of goods.The stability of local governments in Tibet and Central China and favourable border trade policies along with Britain’s colonial expansion and commercial interests stimulated further development of traditional trade routes.However,India’s strategic miscalculation and“Forward Policy”instigated the decline phase,while the demands of regional cooperation and development are currently the key drivers of the restoration and construction phase.Finally,to shelve disputes,promote cooperation and development,and enhance political mutual trust,governments should recover and construct traditional trade routes by replanning and constructing border trade markets,expanding border trade,developing pilgrimage and tourism,and strengthening cross-border cooperative resear h under global climate change.
文摘The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise compliance with it. On the other side, Model Driven Development (MDD) has been proved as a quite successful paradigm in general-purpose computing. This was the motivation for exploiting the benefits of MDD in the industrial automation domain. With the emerging IEC 61131 specification that defines an object-oriented (OO) extension to the function block model, there will be a push to the industry to better exploit the benefits of MDD in automation systems development. This work discusses possible alternatives to integrate the current but also the emerging specification of IEC 61131 in the model driven development process of automation systems. IEC 61499, UML and SysML are considered as possible alternatives to allow the developer to work in higher layers of abstraction than the one supported by IEC 61131 and to more effectively move from requirement specifications into the implementation model of the system.
文摘Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.
基金Supported by Preparation Project of Science Popularization Materials for Publicity and Education of Soil Environmental Protection,Ministry of Environmental Protection(H201606)
文摘In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countries is introduced.According to characteristics of soil environment and practice of soil environment management in China,the relevant suggestions are discussed,thereby further perfecting construction work of soil environmental quality standards in China.
文摘Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is designed and developed. The design principles for IP-PDPM are described. The system architecture and functions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.
基金Supported by Special Project for Guangxi Science and Technology Bases and Talent(GK AD16380088,GK AD17195040)Key Research and Development Plan of Guangxi(GK AB18221070)+1 种基金Major Science and Technology Project of Guangxi(GK AA17202029,G AA17204058-19,G AA17204058-20)Project of Guangxi Academy of Agricultural Sciences(2015YT87,2018YT29,2018YM05)
文摘Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting economic development and helping farmers to get out of poverty in Guangxi. But there is almost nothing to do with the processing and utilization. Taking the route of processing and utilization is an inevitable trend of development of Longtan pearl plum industry with the increase of the planting area and yield year by year. In this paper, based on the analysis of edible value of Longtan pearl plum, the development direction of processing and utilization of Longtan pearl plum was expounded, and some suggestions on the problems existing in the processing and utilization were put forward to provide reference for the processing and utilization of Longtan pearl plum.
