The diffusion coefficients(Dapp) and the heterogeneous electron transfer rate constants(ks)for ferrocene in several polymer solvents were determined by using steady-stae voltammetry. Thetemperature dependence of the t...The diffusion coefficients(Dapp) and the heterogeneous electron transfer rate constants(ks)for ferrocene in several polymer solvents were determined by using steady-stae voltammetry. Thetemperature dependence of the two parameters indicates Arrhenius behavior. The polymer solventeffects on diffusion and electron transfer dynamics of ferrocene were discussed展开更多
This paper describes the synthesis and free radical ring-opening polymerization of 2-methyl-and 2-methyl-9-n-butyl (-7-methylene-1, 4, 6-trioxaspiro (4, 4) nonane). The structures of the two polymers were verified by ...This paper describes the synthesis and free radical ring-opening polymerization of 2-methyl-and 2-methyl-9-n-butyl (-7-methylene-1, 4, 6-trioxaspiro (4, 4) nonane). The structures of the two polymers were verified by IR, 'H and ^(13)C NMR spectra. The substituent on 9-position of 7-methylene-trioxaspiro (4, 4) nonane affects the structure of polymer and polymerization activity. The polymerization mechanism is discussed.展开更多
In this paper,the functional polymeric active materials were prepared by the grafting copolymerization and their structure and properties were studied.The results show that the structure and properties of these ac- ti...In this paper,the functional polymeric active materials were prepared by the grafting copolymerization and their structure and properties were studied.The results show that the structure and properties of these ac- tive materials have the relative large effects on the properties of gadolinium ion selective electrodes.展开更多
Polymer surface modification constitutes a pivotal strategy for enhancing the efficacy of nanomedicine delivery,where intentional modifications(e.g.,PEGylation,hyaluronic acid coating)are designed to optimize nanocarr...Polymer surface modification constitutes a pivotal strategy for enhancing the efficacy of nanomedicine delivery,where intentional modifications(e.g.,PEGylation,hyaluronic acid coating)are designed to optimize nanocarrier performance.However,conventional approaches remain constrained by the impermeable stratum corneum in transdermal applications.Dissolving microneedles(DMNs)circumvent this barrier by creating transient microchannels,thereby offering an innovative route for cutaneous nanocarriers administration.Nevertheless,the DMN polymeric matrix may unintentionally alter the physicochemical attributes of loaded nanocarriers via non-covalent interactions,giving rise to a distinct“polymer modification effect”(PME)that differs from purposeful surface engineering.Such unintended interfacial phenomena can modulate nanocarrier characteristics and,consequently,dictate their in vivo fate,including release kinetics,biodistribution,clearance,cellular uptake,and other interactions with the biological system.Herein,we review documented cases of DMN polymer-nanocarrier modifications,elucidate the underlying mechanisms and implications of PME,and propose rational strategies for its precise regulation.This conceptual framework is expected to guide the rational design of next-generation nanocarrier-loaded DMN delivery systems.展开更多
文摘The diffusion coefficients(Dapp) and the heterogeneous electron transfer rate constants(ks)for ferrocene in several polymer solvents were determined by using steady-stae voltammetry. Thetemperature dependence of the two parameters indicates Arrhenius behavior. The polymer solventeffects on diffusion and electron transfer dynamics of ferrocene were discussed
基金Supported by National Natural Science Foundation of China
文摘This paper describes the synthesis and free radical ring-opening polymerization of 2-methyl-and 2-methyl-9-n-butyl (-7-methylene-1, 4, 6-trioxaspiro (4, 4) nonane). The structures of the two polymers were verified by IR, 'H and ^(13)C NMR spectra. The substituent on 9-position of 7-methylene-trioxaspiro (4, 4) nonane affects the structure of polymer and polymerization activity. The polymerization mechanism is discussed.
文摘In this paper,the functional polymeric active materials were prepared by the grafting copolymerization and their structure and properties were studied.The results show that the structure and properties of these ac- tive materials have the relative large effects on the properties of gadolinium ion selective electrodes.
基金the financial support from Major Funding of National Natural Science Foundation of China(No.82330112)National Natural Science Foundation of China(Nos.82373800 and 82104070)Guangdong Universities Keynote Regions Special Funded Project(No.2022ZDZX2002)。
文摘Polymer surface modification constitutes a pivotal strategy for enhancing the efficacy of nanomedicine delivery,where intentional modifications(e.g.,PEGylation,hyaluronic acid coating)are designed to optimize nanocarrier performance.However,conventional approaches remain constrained by the impermeable stratum corneum in transdermal applications.Dissolving microneedles(DMNs)circumvent this barrier by creating transient microchannels,thereby offering an innovative route for cutaneous nanocarriers administration.Nevertheless,the DMN polymeric matrix may unintentionally alter the physicochemical attributes of loaded nanocarriers via non-covalent interactions,giving rise to a distinct“polymer modification effect”(PME)that differs from purposeful surface engineering.Such unintended interfacial phenomena can modulate nanocarrier characteristics and,consequently,dictate their in vivo fate,including release kinetics,biodistribution,clearance,cellular uptake,and other interactions with the biological system.Herein,we review documented cases of DMN polymer-nanocarrier modifications,elucidate the underlying mechanisms and implications of PME,and propose rational strategies for its precise regulation.This conceptual framework is expected to guide the rational design of next-generation nanocarrier-loaded DMN delivery systems.
