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Single-image super-resolution of gamma-ray imaging system using deep denoiser prior based on plug-and-play framework
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作者 Guo-Guang Li Liang Sheng +6 位作者 Bao-Jun Duan Yang Li Yan Song Zi-Jian Zhu Wei-Peng Yan Dong-Wei Hei Qing-Zi Xing 《Matter and Radiation at Extremes》 2025年第2期56-70,共15页
Gamma-ray imaging systems are powerful tools in radiographic diagnosis.However,the recorded images suffer from degradations such as noise,blurring,and downsampling,consequently failing to meet high-precision diagnosti... Gamma-ray imaging systems are powerful tools in radiographic diagnosis.However,the recorded images suffer from degradations such as noise,blurring,and downsampling,consequently failing to meet high-precision diagnostic requirements.In this paper,we propose a novel single-image super-resolution algorithm to enhance the spatial resolution of gamma-ray imaging systems.A mathematical model of the gamma-ray imaging system is established based on maximum a posteriori estimation.Within the plug-and-play framework,the half-quadratic splitting method is employed to decouple the data fidelit term and the regularization term.An image denoiser using convolutional neural networks is adopted as an implicit image prior,referred to as a deep denoiser prior,eliminating the need to explicitly design a regularization term.Furthermore,the impact of the image boundary condition on reconstruction results is considered,and a method for estimating image boundaries is introduced.The results show that the proposed algorithm can effectively addresses boundary artifacts.By increasing the pixel number of the reconstructed images,the proposed algorithm is capable of recovering more details.Notably,in both simulation and real experiments,the proposed algorithm is demonstrated to achieve subpixel resolution,surpassing the Nyquist sampling limit determined by the camera pixel size. 展开更多
关键词 deep denoiser prior enhance spatial resolution maximum posteriori estimationwithin radiographic diagnosishoweverthe maximum posteriori estimation gamma ray imaging plug play framework recorded images
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Minimum safe thickness of rock plug in karst tunnel according to upper bound theorem 被引量:14
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作者 YANG Zi-han ZHANG Jia-hua 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第9期2346-2353,共8页
High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technic... High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technical problem to be solved for karst tunnel construction. Based on the Hoek-Brown nonlinear failure criterion, the minimum safe thickness of rock plug was investigated in the light of the limit analysis theory. On the basis of the proposed failure mode, the expression of the minimum thickness for rock plug was obtained by means of upper bound theorem in combination with variational principle. The calculation results show the influence of each parameter on safe thickness and reveal the damage range of rock plug. The proposed method is verified by comparing the results with those of the drain cavern of Maluqing Tunnel. The research shows that with the increase of compressive strength and tensile strength as well as constant A of Hoek-Brown criterion, the safe thickness decreases, whereas with the increase of cavern pressure, tunnel diameter, and constant B from Hoek-Brown criterion, the safe thickness increases. Besides, the tensile strength, or constants A and B affect the shear failure angle of rock plug structure, but other parameters do not. In conclusion, the proposed method can predict the minimum safe thickness of rock plug, and is useful for water burst study and prevention measures of tunnels constructed in high-risk karst regions. 展开更多
关键词 karst tunnels rock plug minimum safe thickness upper limit theorem failure mode
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Effect of Stagnation Temperature on the Supersonic Two-Dimensional Plug Nozzle Conception. Application for Air 被引量:2
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作者 Toufik Zebbiche ZineEddine Youbi 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2007年第1期15-28,共14页
When the stagnation temperature of a perfect gas increases, the specific heats and their ratio do not remain constant any more and start to vary with this temperature. The gas remains perfect, its state equation remai... When the stagnation temperature of a perfect gas increases, the specific heats and their ratio do not remain constant any more and start to vary with this temperature. The gas remains perfect, its state equation remains always valid, except it will name in more calorically imperfect gas or gas at High Temperature. The goal of this research is to trace the profiles of the supersonic plug nozzle when this stagnation temperature is taken into account, lower than the threshold of dissociation of the molecules, by using the new formula of the Prandtl Meyer function, and to have for each exit Mach number, several nozzles shapes by changing the value of this temperature. A study on the error given by the PG (perfect gas) model compared to our model at high temperature is presented. The comparison is made with the case of a calorically perfect gas aiming to give a limit of application of this model. The application is for the air. 展开更多
关键词 supersonic flow plug nozzle calorically imperfect gas interpolation Prandtl Meyer functiom stretching fimction Simpson quadrature supersonic parameters conception.
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Production of Rubidium Bose-Einstein Condensate in an Optically Plugged Magnetic Quadrupole Trap
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作者 张东方 高天佑 +2 位作者 孔令冉 李凯 江开军 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第7期120-123,共4页
We experimentally produce the rubidium Bose-Einstein condensate in an optically plugged magnetic quadrupole trap. A far blue-detuned focused laser beam with a wavelength of 532nm is plugged in the center of the magnet... We experimentally produce the rubidium Bose-Einstein condensate in an optically plugged magnetic quadrupole trap. A far blue-detuned focused laser beam with a wavelength of 532nm is plugged in the center of the magnetic quadrupole trap to increase the number of trapped atoms and to suppress the heating. An rf evaporative cooling in the magneto-optical hybrid trap is applied to decrease the atom temperature into degeneracy. The atom number of the condensate is 1.2(0.4)× 10^5 and the temperature is below lOOnK. We also study characteristic behaviors of the condensate, such as phase space density, condensate fraction and anisotropic expansion. 展开更多
关键词 of is BEC in Production of Rubidium Bose-Einstein Condensate in an Optically plugged Magnetic Quadrupole Trap
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Plugging Up the loopholes
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作者 Lan Xinzhen 《ChinAfrica》 2011年第8期37-37,共1页
State regulator tightens supervision over state overseas assets NEW measures to supervise overseas assets of centrally administered state-owned enterprises(SOEs) have been announced by the State-Owned Assets Supervisi... State regulator tightens supervision over state overseas assets NEW measures to supervise overseas assets of centrally administered state-owned enterprises(SOEs) have been announced by the State-Owned Assets Supervision and Administration Commission(SASAC), coming about amid what it termed "increasing complexities." The newly announced pair of regula- 展开更多
关键词 plugging up the loopholes
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Temporary plugging agent transport behavior within visualized multi-fracture created during TPDF in a horizontal well: An experimental study
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作者 Yu-Shi Zou Dian-Yu Li +4 位作者 Can Yang Yan-Chao Li Shi-Cheng Zhang Long-Qing Zou Xin-Fang Ma 《Petroleum Science》 2025年第9期3671-3687,共17页
Temporary plugging and diversion fracturing(TPDF)is widely used to promote the uniform and complex distribution of multi-clustered hydraulic fractures(HFs)in a horizontal well of the unconventional formations.However,... Temporary plugging and diversion fracturing(TPDF)is widely used to promote the uniform and complex distribution of multi-clustered hydraulic fractures(HFs)in a horizontal well of the unconventional formations.However,the migration behavior of temporary plugging agent(TPA),as a function of the concentration and particle size of TPA and cluster-perforation numbers,etc.,determining the effectiveness of this technique,remains unclear.Therefore,this study conducted innovatively a series of TPDF simulation experiments on transparent polymethyl methacrylate(PMMA)specimens(cubic block of 30 cm×30 cm×30 cm)to explore visually the migration behavior of TPA in multi-clustered HFs in a horizontal well.A laboratory hydraulic sandblasting perforation completion technique was implemented to simulate the multi-cluster perforations.All the distributions of wellbore,perforations,HFs,and TPA can be seen clearly inside the PMMA specimen post the experiment.The results show that there are four characteristic plugging positions for the TPA:mouth of HF,middle of HF,tip of HF,and the intersection of HFs.Small particle size TPA tends to migrate to the fracture tip for plugging,while large particle size TPA tends to plug at the fracture mouth.The migration of the TPA is influenced obviously by the morphology of the fracture wall.A smooth fracture wall is conducive to the migration of the TPA to the far end of HFs,but not conducive to generating the plugging zone and HF diversion.In contrast,a"leaf vein"fracture of rough wall is conducive to generating the plugging layer and the diversion of HFs,but not conducive to the migration of the TPA to the far end of HFs.The migration ability of TPA in a"shell"pattern is intermediate between the two above cases.Increasing TPA concentration can encourage TPA to migrate more quickly to the characteristic plugging position,and thereby to promote the creation of effective plugging and subsequently the multi-stage diversion of the HFs.Nevertheless,excessive concentration may cause the TPA to settle prematurely,affecting the propagation of the HFs to the far end.Increasing the number of clusters to a certain extent can encourage TPA to migrate into the HFs and form plugging,and promote the diversion.An evaluation system for the migration ability of granular TPA has been established,and it was calculated that when there is no plugging expectation target,the comprehensive migration ability of small particle size TPA is stronger than that of large particle size TPA.This research provides theoretical foundation for the optimization of temporary plugging parameters. 展开更多
关键词 Temporary plugging and diversion fracturing(TPDF) Polymethyl methacrylate(PMMA) Multi-cluster perforation Temporary plugging agent migration Visualization plugging position
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Enhanced Load-Settlement Curve Forecasts for Open-Ended Pipe Piles Incorporating Soil Plug Constraints Using Shallow and Deep Neural Networks
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作者 Luttfi A.AL-HADDAD Mohammed Y.FATTAH +2 位作者 Wissam H.S.AL-SOUDANI Sinan A.AL-HADDAD Alaa Abdulhady JABER 《China Ocean Engineering》 2025年第3期562-572,共11页
This study investigates the load-bearing capacity of open-ended pipe piles in sandy soil, with a specific focus on the impact of soil plug constraints at four levels(no plug, 25% plug, 50% plug, and full plug). Levera... This study investigates the load-bearing capacity of open-ended pipe piles in sandy soil, with a specific focus on the impact of soil plug constraints at four levels(no plug, 25% plug, 50% plug, and full plug). Leveraging a dataset comprising open-ended pipe piles with varying geometrical and geotechnical properties, this research employs shallow neural network(SNN) and deep neural network(DNN) models to predict plugging conditions for both driven and pressed installation types. This paper underscores the importance of key parameters such as the settlement value,applied load, installation type, and soil configuration(loose, medium, and dense) in accurately predicting pile settlement. These findings offer valuable insights for optimizing pile design and construction in geotechnical engineering,addressing a longstanding challenge in the field. The study demonstrates the potential of the SNN and DNN models in precisely identifying plugging conditions before pile driving, with the SNN achieving R2 values ranging from0.444 to 0.711 and RMSPE values ranging from 24.621% to 48.663%, whereas the DNN exhibits superior performance, with R2 values ranging from 0.815 to 0.942 and RMSPE values ranging from 4.419% to 10.325%. These results have significant implications for enhancing construction practices and reducing uncertainties associated with pile foundation projects in addition to leveraging artificial intelligence tools to avoid long experimental procedures. 展开更多
关键词 pipe piles soil plug artificial neural network bearing capacity forecasts
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Technology of milling bridge plugs and field applications in shale gas horizontal wells with severe casing deformation
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作者 Gang Xiang Jialin Liu Xiaolong Ma 《Natural Gas Industry B》 2025年第1期64-70,共7页
Milling bridge plugs in shale gas wells with severe casing deformation often leads to the accumulation of cuttings,increasing the risk of stuck drill bits.Friction in the wellbore further complicates tool deployment i... Milling bridge plugs in shale gas wells with severe casing deformation often leads to the accumulation of cuttings,increasing the risk of stuck drill bits.Friction in the wellbore further complicates tool deployment into the horizontal section,posing challenges to efficient plug drilling and achieving wellbore access to the target layer.This paper integrates the theory of positive displacement motors and models their actual working characteristics to study the milling of bridge plugs in severely deformed horizontal wells.It examines the effects of coiled tubing diameter and wall thickness on the bending load of horizontal sections and discusses key technical requirements,including the timing of plug drilling,extending the run in the horizontal section,parameter control,and real-time field analysis.Field practices have shown that after casing deformation occurs,priority should be given to drilling out the bridge plugs below the point of deformation.The primary factors contributing to stuck drills in deformed wells include smaller mill shoe sizes and larger cuttings sizes.Short well-washing cycles and targeted cuttings removal can effectively reduce sticking risks.If sticking occurs,high-tonnage pulling should be avoided.Instead,releasing the stick through up-anddown string motion,combined with high-volume nozzle spraying and annulus pumping,is recommended.The selection of coiled tubing should consider diameter,wall thickness,and steel grade to handle complex situations.Larger diameters,thicker walls,and low-frequency,multi-head hydraulic oscillators are more effective for unlocking horizontal sections.This approach can reduce the risk of drill sticking and solve the problem of horizontal section lock-ups,offering a reliable solution for smooth drilling and efficient production in wells with severe casing deformation. 展开更多
关键词 Shale gas Coiled tubing Casing deformation Milling bridge plug Risk control
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Preparation and Application of an Epoxy Soybean Oil-Based Plugging Agent
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作者 Yongming Li Dingyuan Zhang +1 位作者 Yadong Chen Jiandu Ye 《Fluid Dynamics & Materials Processing》 2025年第2期261-277,共17页
Resin plugging agents play a pivotal role in addressing casing damage in oil and gas fields.However,the widespread use of epoxy resin is constrained by its high cost and non-renewable origin,while plant-based resins o... Resin plugging agents play a pivotal role in addressing casing damage in oil and gas fields.However,the widespread use of epoxy resin is constrained by its high cost and non-renewable origin,while plant-based resins often suffer from inadequate mechanical properties,which limit their effectiveness in such applications.This study introduces BEOPA,an innovative,renewable,high-strength resin plugging agent derived from epoxidized soybean oil(ESO)and enhanced with bisphenol A-type benzoxazine(BZ).In this study,the synthesis process,reactionmechanism,and application performance of this novelmaterial are systematically presented,explored and optimized.It is shown that the optimal formulation of BEOPA includes 41.4 wt%ESO,24.8 wt%BZ,24.8 wt%methylhexahydrophthalic anhydride(MHHPA),8.2 wt%styrene(ST),and 0.8 wt%N,N-dimethylbenzylamine(BDMA),yielding an impressive compressive strength of 93.7 MPa.The integration of ESO and BZ creates an intricate and robust double crosslinking network,significantly enhancing material strength and durability.BEOPA exhibits a tunable curing time,ranging from 0.5 to 15 h,with viscosities below 300 mPa⋅s at 25℃and 75mPa⋅s at 50℃.Furthermore,it demonstrates exceptional thermal stability within the 100℃-150℃range,even in environments with mineral salt concentrations as high as 43,330 mg/L.Remarkably,BEOPA achieves superior plugging performance,sustaining breakthrough pressures exceeding 29.7 MPa in 1 mm crack cores. 展开更多
关键词 Casing damage epoxidized soybean oil BENZOXAZINE mechanical properties plugging properties
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Plugging mode of flaky lost circulation materials within fractures and mechanism to enhance pressure-bearing capacity for the plugging zone
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作者 Kun Guo Yi-Li Kang +3 位作者 Cheng-Yuan Xu Chong Lin Ling-Jie Zhang Li-Jun You 《Petroleum Science》 2025年第8期3315-3332,共18页
During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to dril... During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to drilling fluids is the most common method for controlling lost circulation.Among these,granular LCMs are widely used,but the application frequency of flaky LCMs has been increasing annually due to their unique morphology.However,the migration and plugging behavior of flaky LCMs within fractures,and the mechanisms enhancing the pressure-bearing capacity of the plugging zone are not well understood.Therefore,this study conducted visual plugging experiments and dynamic fracture plugging experiments to evaluate the plugging mode and pressure-bearing capacity of the plugging slurry with various particle sizes and concentrations of flaky LCMs.The experimental results demonstrate that the fracture plugging process can be divided into four stages:uniform flow stage of the plugging slurry,formation and development stage of the bridging area,formation and development stage of the plugging area,and pressure-bearing stage of the plugging zone.The inclusion of flaky LCMs notably reduces the duration of stages 1 and 2,while simultaneously increasing the proportion of the plugging zone and enhancing its surface porosity.Flaky LCMs reduce the effective fracture width through“interception”and“co-bridging”modes,thus improving plugging zone formation efficiency.Appropriate particle size and concentration of flaky LCMs increase the area and length of the plugging zone.This reduces the fracture width increment caused by injection pressure and enhances frictional force between the plugging zone and fracture surface,thereby improving the pressure-bearing capacity of the plugging zone.However,excessively high concentrations of flaky LCMs result in decreased structural stability of the plugging zone,and excessively large particle sizes increase the risk of plugging outside fracture inlet.The recommended concentration of flaky LCMs in the plugging slurry is 2%–3%,with a particle size 1.2 to 1.5 times that of the bridging granular LCMs and not exceeding twice the fracture width.This study provides a theoretical foundation for selecting LCMs and designing plugging formulations for field applications. 展开更多
关键词 Lost circulation Flaky lost circulation materials Fracture plugging zone Visualization Pressure-bearing capacity
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Experimental study of a circulation agent dynamic plugging for multi-scale natural fractures
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作者 Zhao-Wen Hu Yi-Qun Zhang +3 位作者 Jin-Shan Wang Xin-Yu Wang Yu Qin Ya Liu 《Petroleum Science》 2025年第9期3641-3654,共14页
Lost circulation critically jeopardizes drilling safety and efficiency,and remains an unresolved challenge in oil and gas engineering.In this paper,by utilizing the self-developed dynamic plugging apparatus and synthe... Lost circulation critically jeopardizes drilling safety and efficiency,and remains an unresolved challenge in oil and gas engineering.In this paper,by utilizing the self-developed dynamic plugging apparatus and synthetic cores containing large-scale fractures,experimental research on the circulation plugging of different materials was conducted.Based on the D90 rule and fracture mechanical aperture model,we analyze the location of plugging layer under dynamic plugging mechanism.By setting different parameters of fracture width and injection pressure,the laws of cyclic plugging time,pressure bearing capacity and plugging layers formation were investigated.The results show that the comprehensive analysis of particle size and fracture aperture provides an accurate judgment of the entrance-plugging phenomenon.The bridging of solid materials in the leakage channel is a gradual process,and the formation of a stable plug requires 2–3 plug-leakage cycles.The first and second cyclic plugging time was positively correlated with the fracture width.Different scales of fractures were successfully plugged with the bearing pressure greater than 6 MPa,but there were significant differences in the composition of the plugging layer.The experimental results can effectively prove that the utilized plugging agent is effective and provides an effective reference for dynamic plugging operation. 展开更多
关键词 Dynamic plugging Large scale fracture Lost circulation material Laboratory experiments Fracture aperture
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Enhancing uniformity of multi-fracture propagation by temporary plugging and diversion fracturing in a horizontal well with multicluster perforations
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作者 Xin Chang Shi-Long Teng +2 位作者 Xing-Yi Wang Yin-Tong Guo Chun-He Yang 《Petroleum Science》 2025年第9期3688-3708,共21页
Multi-stage and multi-cluster fracturing(MMF)is a crucial technology in unconventional oil and gas development,aiming to enhance production by creating extensive fracture networks.However,achieving uniform expansion o... Multi-stage and multi-cluster fracturing(MMF)is a crucial technology in unconventional oil and gas development,aiming to enhance production by creating extensive fracture networks.However,achieving uniform expansion of multi-cluster hydraulic fractures(HFs)in MMF remains a significant challenge.Field practice has shown that the use of temporary plugging and diversion fracturing(TPDF)can promote the balanced expansion of multi-cluster HFs.This study conducted TPDF experiments using a true triaxial fracturing simulation system setting a horizontal well completion with multi-cluster jetting perforations to investigate the equilibrium initiation and extension of multi-cluster fractures.The influence of key parameters,including cluster spacing,fracturing fluid viscosity,differential stress,and fracturing fluid injection rate,on fracture initiation and propagation was systematically examined.The results indicate that while close-spaced multi-cluster fracturing significantly increases the number of HFs,it also leads to uneven extension of HFs in their propagation.In contrast,TPDF demonstrates effectiveness in mitigating uneven HF extension,increasing the number of HFs,and creating a larger stimulated reservoir volume,ultimately leading to improved oil and gas well productivity.Moreover,under conditions of high differential stress,the differential stress within the formation exerts a stronger guiding effect in HFs,which are more closely aligned with the minimum principal stress.Low-viscosity fluids facilitate rapid and extensive fracture propagation within the rock formation.High-volume fluid injection,on the other hand,more comprehensively fills the formation.Therefore,employing lowviscosity and high-volume fracturing is advantageous for the initiation and extension of multi-cluster HFs. 展开更多
关键词 Non-uniformity of fracture propagation Temporary plugging and diversion FRACTURING Multi-cluster hydraulic fracturing Fracture propagation
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Plug-in混合动力汽车能量管理策略全局优化研究 被引量:33
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作者 张博 李君 +2 位作者 高莹 杨成宏 尹雪峰 《中国机械工程》 EI CAS CSCD 北大核心 2010年第6期715-720,共6页
应用动态规划全局优化算法,针对并联式Plug-in混合动力汽车在不同行驶里程下的能量管理策略进行了全局优化研究。结果表明:车辆的行驶里程小于55km时应使用电动机为主的能量管理策略,当车辆的行驶里程大于55km时应使用发动机为主的能量... 应用动态规划全局优化算法,针对并联式Plug-in混合动力汽车在不同行驶里程下的能量管理策略进行了全局优化研究。结果表明:车辆的行驶里程小于55km时应使用电动机为主的能量管理策略,当车辆的行驶里程大于55km时应使用发动机为主的能量管理策略;在动态规划最优控制下,车辆行驶里程为55km时整车经济性能最佳,行驶里程小于110km时整车平均等价油耗为2.7L/100km,相对于原型车经济性提高了近58%。 展开更多
关键词 plug—in混合动力汽车 能量管理策略 动态规划 优化设计
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Smart Plug泪小管塞治疗水液缺乏型干眼症临床初步观察 被引量:8
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作者 陈晓莉 张世华 廖润斌 《国际眼科杂志》 CAS 2015年第4期723-724,共2页
目的:探讨Smart Plug泪小管塞治疗水液缺乏型干眼症临床疗效。方法:选取2012-05/2013-04期间我院收治的48例水液缺乏型干眼症患者为研究对象,进行Smart Plug泪小管塞治疗,观察术后临床疗效、基础泪液分泌试验(SchirmerⅠtest,SⅠt)、泪... 目的:探讨Smart Plug泪小管塞治疗水液缺乏型干眼症临床疗效。方法:选取2012-05/2013-04期间我院收治的48例水液缺乏型干眼症患者为研究对象,进行Smart Plug泪小管塞治疗,观察术后临床疗效、基础泪液分泌试验(SchirmerⅠtest,SⅠt)、泪膜破裂时间(tear break up time,BUT)、角膜荧光素染色(fluoreseein staining,FL)变化。结果:本组48例患者,显效31例(65%),有效14例(29%),无效3例(6%),总有效率为94%。治疗前,患者SⅠt,BUT,FL分别为3.49±1.24mm/5min,3.15±1.07s,2.52±0.11分。治疗后,患者SⅠt,BUT,FL均明显改善,与治疗前比较,差异具有统计学意义(P<0.05)。1例患者术后有异物感,8h后栓子脱落;1例患者于术后8mo出现肉芽组织,泪小管塞脱落。其余病例无下泪小管感染或肉芽肿。结论:Smart Plug泪小管塞治疗水液缺乏型干眼症疗效确切,能够有效缓解临床症状,值得临床推广。 展开更多
关键词 SMART plug 泪小管塞 水液缺乏型干眼症 疗效 并发症
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PLUG引物和IT引物在顶芒山羊草分子标记建立中的通用性分析 被引量:6
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作者 宫文萍 李凯 +6 位作者 程敦公 武智民 李洪振 韩冉 李豪圣 刘成 刘建军 《山东农业科学》 2019年第7期10-16,共7页
分子标记是检测和追踪小麦背景中近缘物种染色体的重要手段。依据禾本科物种基因共线性原则,基于基因序列设计的引物在不同物种中可能具有通用性。本研究对水稻PLUG引物和簇毛麦IT引物在顶芒山羊草中的通用性进行了分析,并建立了顶芒山... 分子标记是检测和追踪小麦背景中近缘物种染色体的重要手段。依据禾本科物种基因共线性原则,基于基因序列设计的引物在不同物种中可能具有通用性。本研究对水稻PLUG引物和簇毛麦IT引物在顶芒山羊草中的通用性进行了分析,并建立了顶芒山羊草染色体特异IT标记。供试的397对PLUG引物和841对IT引物对小麦-顶芒山羊草双二倍体与中国春的扩增结果显示,377对(95.0%)PLUG引物和593对(70.5%)IT引物可以在供试材料中扩增出清晰条带。因此,PLUG引物在顶芒山羊草中的通用性优于IT引物。相比小麦对照,PLUG引物和IT引物能在小麦-顶芒山羊草双二倍体中扩增出多态性条带的引物数分别有17对和5对,分别占供试PLUG引物和IT引物的4.3%和0.6%。利用获得的IT多态性引物对一套小麦-顶芒山羊草附加系和一套小麦-卵穗山羊草附加系进行扩增,结果发现仅引物CINAU1060、CINAU1465和CINAU1517能在相应附加系中扩增出大小分别约为300、480bp和320bp的多态性标记,为小麦背景中顶芒山羊草染色质的鉴定提供了新的检测手段。然而,本研究中IT引物建立顶芒山羊草分子标记的比率仅为0.4%,低于我们之前用PLUG引物建立顶芒山羊草分子标记的比率(8.9%)。 展开更多
关键词 顶芒山羊草 分子标记 plug引物 IT引物 通用性
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Visiplug~泪小管塞栓治疗中度以上干眼的临床疗效分析 被引量:2
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作者 黄俊 石珂 +3 位作者 金奇芳 游志鹏 张倩 毛新帮 《眼科新进展》 CAS 北大核心 2018年第9期876-879,共4页
目的探讨应用眼表综合分析仪评估Visi Plug泪小管塞栓治疗中度以上干眼的临床疗效。方法选择2015年1月至2016年3月于我院诊断为干眼并使用人工泪液及普拉洛芬滴眼液4周后仍有症状并再次评分为中度以上干眼的患者32例(64眼),分成治疗... 目的探讨应用眼表综合分析仪评估Visi Plug泪小管塞栓治疗中度以上干眼的临床疗效。方法选择2015年1月至2016年3月于我院诊断为干眼并使用人工泪液及普拉洛芬滴眼液4周后仍有症状并再次评分为中度以上干眼的患者32例(64眼),分成治疗组和对照组,每组各16例32眼,治疗组使用泪小管塞栓联合人工泪液及普拉洛芬滴眼液进行治疗,对照组继续使用人工泪液和普拉洛芬滴眼液治疗,随访6~12个月,分别观察治疗前及治疗后2周、1个月、3个月、6个月、末次随访时干眼主观症状问卷调查得分、眼表综合分析仪中泪膜破裂时间、泪河高度、眼红指数及角膜荧光素染色检查情况并评估临床疗效。结果治疗后1 a,主观症状问卷调查评分治疗组由术前(16.95±5.12)分降至(4.36±0.16)分,对照组由术前(17.22±5.20)分降至(5.50±0.29)分,两组治疗前差异无统计学意义(P>0.05),治疗后1 a差异有统计学意义(P<0.01)。治疗组、对照组治疗前与治疗后不同时间点的泪膜破裂时间、泪河高度、眼红指数、角膜荧光素染色评分的差异均有统计学意义(均为P<0.05)。两组在治疗后泪膜破裂时间均较治疗前显著延长、泪河高度均较治疗前显著增加,眼红指数评分和角膜荧光素染色评分均较治疗前显著降低,差异均有统计学意义(均为P<0.05),但治疗组与对照组相比,泪膜破裂时间更长,泪河高度改善更为明显,眼红指数评分与角膜荧光素染色评分更低。结论 Visi Plug泪小管塞栓治疗中度以上干眼具有良好的临床效果。应用眼表综合分析仪评估Visi Plug~泪小管塞栓治疗中度以上干眼的临床疗效更加客观、简便。 展开更多
关键词 眼表综合分析仪 Visi plug泪小管塞栓 干眼 临床疗效
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模糊神经网络算法Plug in电动车能量管理控制器 被引量:1
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作者 肖铎 戚伟 +1 位作者 庞文尧 汪秋婷 《电源技术》 CAS CSCD 北大核心 2012年第11期1685-1688,共4页
针对Plug in混合动力汽车研究设计基于模糊神经网络算法的整车能量管理控制器。将驾驶行为用神经网络进行建模,驾驶模式、踏板(油门和刹车)位置以及当前车轮力矩作为神经网络输入,目标力矩作为输出;并将道路类型、目标力矩、电池SOC、... 针对Plug in混合动力汽车研究设计基于模糊神经网络算法的整车能量管理控制器。将驾驶行为用神经网络进行建模,驾驶模式、踏板(油门和刹车)位置以及当前车轮力矩作为神经网络输入,目标力矩作为输出;并将道路类型、目标力矩、电池SOC、当前车轮力矩为模糊输入变量,以满足整车动力性能、燃油经济型和极限边界极值为约束条件,对混合动力汽车的能量进行分配与管理,用advsior软件进行了仿真,基于该算法在DSP硬件平台设计实现能量管理控制器,通过算法仿真和样车测试表明:在行驶里程60 km等价燃油经济型最好,随着行驶里程增加燃油经济型下降,整个测试过程中样车动力性能以及各部件工况良好。 展开更多
关键词 plug in混合动力 能量管理 模糊神经网络
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Plug封堵器新方法在细小动脉导管未闭治疗中的应用 被引量:1
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作者 杨栋 张伟华 +3 位作者 光雪峰 邓洁 鲁一兵 薛强 《中国介入心脏病学杂志》 2011年第6期332-335,共4页
目的探讨Plug封堵器新方法在细小动脉导管未闭介入治疗中的临床疗效。方法选择细小动脉导管未闭的患者38例,全部常规采取经肺动脉侧释放法,可以建立轨道的患者20例为对照组,如果经肺动脉侧不能建立轨道,则采用冠脉技术,经主动脉侧释放... 目的探讨Plug封堵器新方法在细小动脉导管未闭介入治疗中的临床疗效。方法选择细小动脉导管未闭的患者38例,全部常规采取经肺动脉侧释放法,可以建立轨道的患者20例为对照组,如果经肺动脉侧不能建立轨道,则采用冠脉技术,经主动脉侧释放法的患者18例为试验组,于术后造影以及术后3天、1个月、3个月、6个月行超声心动图随访,观察研究两组封堵成功率、并发症和远期疗效。结果两组技术成功率100%,试验组的X线辐射剂量为(140.0±5.4)mGy,手术总时间为(20.0±2.6)min,对照组的X线辐射剂量为(200.0±6.2)mGy,手术总时间为(30.0±3.1)min,术后3天、1个月、3个月、6个月超声心动图随访均无残余分流,封堵器位置好,肺动脉压力正常。结论 Plug封堵器新方法介入治疗细小动脉导管未闭安全可行,试验组的X线辐射剂量及手术总时间均较对照组少,试验组优于对照组。 展开更多
关键词 plug封堵器 动脉导管未闭 导管插入术
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Smart Plug泪道栓塞术治疗干眼症的临床观察 被引量:4
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作者 吴承杰 曹俊杰 曹红云 《中国中医药咨讯》 2011年第15期155-155,共1页
目的:观察Smart Plug泪道栓塞术治疗干眼症的临床效果。方法:选取50例干眼症患者,采用Smart Plug泪道栓塞术进行治疗,随访一年,通过泪膜破裂时间(TBUT)、泪液分泌试验(Schirmer I试验,SIT)和角膜荧光素染色(FL)记录结果,... 目的:观察Smart Plug泪道栓塞术治疗干眼症的临床效果。方法:选取50例干眼症患者,采用Smart Plug泪道栓塞术进行治疗,随访一年,通过泪膜破裂时间(TBUT)、泪液分泌试验(Schirmer I试验,SIT)和角膜荧光素染色(FL)记录结果,观察临床疗效。结果:治疗前后,TBUT、SIT和FL结果比较都有显著性差异,P〈0.05。患者同时诉主观症状改善,总有效率为96.0%。结论:Smart Plug泪道栓塞术治疗干眼症效果明显,值得临床应用及推广。 展开更多
关键词 SMART plug泪道栓塞术 干眼症
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Combination of Plugging and Acidization Improves Injection Profile
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作者 赵普春 赵化廷 杨新明 《Petroleum Science》 SCIE CAS CSCD 2004年第4期77-87,共11页
Plugging agent treatment and acid stimulation have completely different mechanisms for improving injection profiles. In this paper, a hybrid procedure is introduced to reduce the damage of the plugging agent to low a... Plugging agent treatment and acid stimulation have completely different mechanisms for improving injection profiles. In this paper, a hybrid procedure is introduced to reduce the damage of the plugging agent to low and medium permeability zones and the penetration radius of acid into high permeability zones. The procedure is: First inject plugging agent to block high permeability zones, and then inject acid to remove plugging agent damage from the low and medium permeability zones and stimulate them. To perform this procedure successfully, three kinds of plugging agents, namely strong strength plugging agent for the wells with fractures or high permeability streaks, weak gel for those with thick layer in which serious heterogeneity exists, temporary plugging agent for those in which the absorption ability of high permeability zones needs maintaining, were screened out for use in different reservoirs. Several acid systems were evaluated to be compatible with the three kinds of plugging agents. The objectives of this paper are:(1)To show the screen results about the compatible plugging agent and acid; 2 To show how to optimize the operation process;(3)To tell some experience gained ( ) from the oilfield applications of this technique. From Jan. 2001 to Dec. 2002, 46 operations using this procedure were carried out in Weicheng and Mazhai Oilfields of SINOPEC. Results show that the average benefit/cost ratio is over 3.5. Experience acquired from these applications was summarized in the paper. 展开更多
关键词 Profile Control plugging and acid inject profile IMPROVE TECHNIQUE
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