The mpox(formerly known as monkeypox)outbreak was declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)on two separate occasions,with the PHEIC status remaining in eff...The mpox(formerly known as monkeypox)outbreak was declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)on two separate occasions,with the PHEIC status remaining in effect following the second declaration on August 14,2024[1,2].The causative agent,mpox virus(MPXV),is a double-stranded DNA virus belonging to the genus Orthopoxvirus within the family Poxviridae[3].MPXV produce two antigenically distinct infectious virion forms:intracellular mature virions(IMVs)and extracellular enveloped virions(EEVs).Currently,the prevention and control of mpox have several challenges,including sustained human-to-human transmission,the increasing frequency and geographic spread of outbreaks,and ongoing viral adaptive evolution[4].These challenges are likely driven by the discontinuation of smallpox vaccination and the waning immunity in current population cohorts.展开更多
基金supported by the National Key Research and Development Program of China(grant number 2025YFC2311800 to H.W.)the National Natural Science Foundation of China(grant number 32270157 to H.W.)the Beijing Nova Program(to H.W.).
文摘The mpox(formerly known as monkeypox)outbreak was declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)on two separate occasions,with the PHEIC status remaining in effect following the second declaration on August 14,2024[1,2].The causative agent,mpox virus(MPXV),is a double-stranded DNA virus belonging to the genus Orthopoxvirus within the family Poxviridae[3].MPXV produce two antigenically distinct infectious virion forms:intracellular mature virions(IMVs)and extracellular enveloped virions(EEVs).Currently,the prevention and control of mpox have several challenges,including sustained human-to-human transmission,the increasing frequency and geographic spread of outbreaks,and ongoing viral adaptive evolution[4].These challenges are likely driven by the discontinuation of smallpox vaccination and the waning immunity in current population cohorts.
