The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activit...The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.展开更多
BACKGROUND While existing literature on ischiofemoral impingement syndrome(IFI)predominantly emphasizes surgical interventions or generalized physical therapy approaches,there remains a paucity of evidence regarding s...BACKGROUND While existing literature on ischiofemoral impingement syndrome(IFI)predominantly emphasizes surgical interventions or generalized physical therapy approaches,there remains a paucity of evidence regarding structured,multimodal rehabilitation programs targeting biomechanical deficits in IFI.This case report evaluates the efficacy of a multimodal rehabilitation program addressing a critical gap in conservative management strategies.CASE SUMMARY The patient underwent comprehensive physical and clinical examination,including hip X-ray and magnetic resonance imaging investigations.The patient completed the Musculoskeletal Health Questionnaire(MSK-HQ)and numerical pain rating scale(NPRS).The patient underwent a two-month tailored structured physical therapy intervention and repeated the same assessment afterwards.The patient's substantial reduction in pain,reflected by a significant decrease in the patient’s NPRS score from 9 to 3 points,signifies a positive clinical response.This outcome,coupled with the significant improvement in the patient's health-related quality of life according to the MSK-HQ score,which increased from 12 to 48 points,underscores the success of our research.CONCLUSION The study highlights the importance of a comprehensive approach to diagnosing and managing IFI,combining clinical assessment with imaging and implementing a multimodal rehabilitation program for optimal outcomes.展开更多
Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”C...Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”Cave 168 is a key component of the Beishan Rock Carvings.At present,several through-going cracks have developed in the roof of Cave 168,severely compromising the structural stability of the grotto.The early internal steel plate supports have suffered severe corrosion and can no longer provide effective reinforcement.In addition,the presence of steel columns obstructs visitor access and negatively affects the viewing experience.A new reinforcement method is urgently needed.Therefore,studying the deformation patterns of the structure is of critical importance.This study analyzes the stratigraphic parameters and fracture distribution of Cave 168,considering key influencing factors such as rainfall,self-weight,and the overlying Quaternary soil.On-site monitoring and physical model experiments were conducted to evaluate the changes in roof crack width and displacement before and after reinforcement with negative Poisson's ratio(NPR)anchor cables.The results reveal that the roof of Cave 168 contains several through-going cracks and numerous microcracks,which serve as infiltration channels for surface water.These accelerate the softening of the mudstone and pose a significant threat to the cave's structural safety.During the experiment,the main change in the crack exhibited a“semi-archshaped”propagation pattern.In the first ten minutes,as the rock transitioned from dry to moist conditions,a slight crack closure was observed.As rainfall continued,crack propagation accelerated.After rainfall ceased,crack width remained stable over a short period.Under NPR anchor support,the influence of rainfall on roof settlement was effectively mitigated,ensuring the safety and stability of the roof.The NPR anchors successfully limited the roof settlement to within 0.3 mm and provided effective control over both total and differential settlement.These findings offer valuable insights into the application of NPR anchor cables in the conservation of grotto heritage structures.展开更多
It explores the integration of rehabilitation and palliative care in cancer management,advocating for a holistic approach that addresses the diverse needs of patients throughout their treatment journey.Traditional can...It explores the integration of rehabilitation and palliative care in cancer management,advocating for a holistic approach that addresses the diverse needs of patients throughout their treatment journey.Traditional cancer care often prioritizes curative interventions at the expense of overall well-being,leading to a fragmented experience for patients.By combining rehabilitation-focused on restoring function and improving physical health-with palliative care-emphasizing symptom management and quality of life-healthcare providers can create a comprehensive support system.The essay highlights the importance of interdisciplinary collaboration among healthcare professionals,as well as the need for education and training to implement this integrated model effectively.Additionally,it addresses potential barriers such as funding limitations and institutional resistance.Ultimately,the integration of these two disciplines represents a critical evolution in cancer care,enhancing patient outcomes and ensuring that individuals receive compassionate,patient-centered support throughout their journey.展开更多
A complex geological environment with faults can be encountered in the process of coal mining.Fault activation can cause instantaneous structure slipping,releasing a significant amount of elastic strain energy during ...A complex geological environment with faults can be encountered in the process of coal mining.Fault activation can cause instantaneous structure slipping,releasing a significant amount of elastic strain energy during underground coal mining.This would trigger strong rockburst disasters.To understand the occurrence of fault-slip induced rockbursts,we developed a physical model test system for fault-slip induced rockbursts in coal mine drifts.The boundary energy storage(BES)loading apparatus and bottom rapid retraction(BRR)apparatus are designed to realize energy compensation and continuous boundary stress transfer of the surrounding rocks for instantaneous fault slip,as well as to provide space for the potential fault slip.Taking the typical fault-slip induced rockburst in the Xinjulong Coal Mine,China,as the background,we conducted a model test using the test system.The deformation and stress in the rock surrounding the drift and the support unit force during fault slip are analyzed.The deformation and failure characteristics and dynamic responses of drifts under fault-slip induced rockbursts are obtained.The test results illustrate the rationality and effectiveness of the test system.Finally,corresponding recommendations and prospects are proposed based on our findings.展开更多
BACKGROUND Long-term chemotherapy for patients with gastric cancer(GC),facilitated by peripherally inserted central catheter(PICC)catheterization,reduces vascular damage and enhances drug delivery efficiency but carri...BACKGROUND Long-term chemotherapy for patients with gastric cancer(GC),facilitated by peripherally inserted central catheter(PICC)catheterization,reduces vascular damage and enhances drug delivery efficiency but carries risks of catheter-related complications.A combination of group psychological nursing and physical mo-vement care significantly mitigates the risk of venous thrombosis and improves psychological well-being,and enhances motor function,underscoring its clinical importance.AIM To assess group psychological and physical movement nursing in preventing venous thrombosis in patients with PICC GC.METHODS Sixty-five GC patients with PICC,admitted from January 2022 to January 2023,were randomly divided into two groups using the lottery method:A control group(n=35,routine nursing)and an observation group(n=30,routine nursing plus psychological nursing and physical movement nursing).Both groups re-ceived continuous care for 2 weeks.Pre-nursing and post-nursing data on psycho-logical state,physical function,chemotherapy-related thrombosis incidence,and cancer-related fatigue were analyzed using SPSS 26.0 and GraphPad Prism 8.0.RESULTS After nursing,both groups showed reduced Hamilton Anxiety Scale scores and increased General Perceived Self-Efficacy Scale scores,with the observation group performing better(P<0.05).The Functional Comprehensive Assessment score for the observation group after nursing was(65.42±2.35)points,lower than the control group’s(62.19±4.33)points(P<0.05).Although no significant difference was observed in the incidence of venous thrombosis between the two groups(χ2=0.815,P=0.367),the observation group had lower incidence.Both groups showed decreased Revised Piper Fatigue Scale scores,with the observation group scoring lower(P<0.05).CONCLUSION Group psychological and physical movement nursing for patients with PICC reduces venous thrombosis risk,improves psychological well-being,cancer-related fatigue,and physical function,making it highly promotable.展开更多
This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic biomaterials.During the SPD process,a solid material sample is subjected to very hig...This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic biomaterials.During the SPD process,a solid material sample is subjected to very high loads without a significant change in sample dimensions.In the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more detail.Considering that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is given.Moreover,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.展开更多
This article comments on the work by Soresi and Giannitrapani.The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease(MASLD)is the use o...This article comments on the work by Soresi and Giannitrapani.The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease(MASLD)is the use of glucagon-like peptide 1 receptor agonists,especially when used in combination therapy.However,despite their notable efficacy,these drugs were not initially designed to target MASLD directly.In a groundbreaking development,the Food and Drug Administration has recently approved resmetirom,the first treatment specifically aimed at reducing liver fibrosis in metabolic-associated steatohepatitis.Resmetirom,an orally administered,liver-directed thyroid hormone beta-selective agonist,acts directly on intrahepatic pathways,enhancing its therapeutic potential and marking the beginning of a new era in the treatment of MASLD.Furthermore,the integration of lifestyle modifications into liver disease management is an essential component that should be considered and reinforced.By incorporating dietary changes and regular physical exercise into treatment,patients may achieve improved outcomes,reducing the need for pharmacological interventions and/or improving treatment efficacy.As a complement to medical therapies,lifestyle factors should not be overlooked in the broader strategy for managing MASLD.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiqu...Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.展开更多
In general,the rapid growth of α-Fe clusters is a challenge in high Fe-content Fe-based amorphous alloys,negatively affecting their physical properties.Herein,we introduce an efficient and rapid post-treatment techni...In general,the rapid growth of α-Fe clusters is a challenge in high Fe-content Fe-based amorphous alloys,negatively affecting their physical properties.Herein,we introduce an efficient and rapid post-treatment technique known as ultrasonic vibration rapid processing(UVRP),which enables the formation of high-density strong magnetic α-Fe clusters,thereby enhancing the soft magnetic properties of Fe_(78)Si(13)B_(9) amorphous alloy ribbon.展开更多
The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by phy...The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by physical attacks,EMP(electromagnetic pulse)events,or cyberattacks,such disruptions could cripple essential services like water supply,healthcare,communication,and transportation.Research indicates that an attack on just nine key substations could result in a coast-to-coast blackout lasting up to 18 months,leading to economic collapse,civil unrest,and a breakdown of public order.This paper explores the key vulnerabilities of the grid,the potential impacts of prolonged blackouts,and the role of AI(artificial intelligence)and ML(machine learning)in mitigating these threats.AI-driven cybersecurity measures,predictive maintenance,automated threat response,and EMP resilience strategies are discussed as essential solutions to bolster grid security.Policy recommendations emphasize the need for hardened infrastructure,enhanced cybersecurity,redundant power systems,and AI-based grid management to ensure national resilience.Without proactive measures,the nation remains exposed to a catastrophic power grid failure that could have dire consequences for society and the economy.展开更多
Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and al...Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.展开更多
Early intervention for sensorineural hearing loss(SNHL)in childhood is crucial for auditory and language development.In recent years,innovative auditory stimulation techniques and speech therapy strategies,such as mid...Early intervention for sensorineural hearing loss(SNHL)in childhood is crucial for auditory and language development.In recent years,innovative auditory stimulation techniques and speech therapy strategies,such as middle ear implants,cochlear implants,auditory brainstem implants,and midbrain implants,have provided new avenues for improving patient outcomes.Additionally,basic research advancements in cell reprogramming and regeneration,stem cell therapy,and targeted drug delivery offer promising approaches to meet the individualized needs of children with SNHL.However,many challenges and unresolved issues remain in the treatment of SNHL.This article comments on the case report,which describes a female pediatric patient with SNHL who underwent foot reflexology which led to the normalization of hearing thresholds.Reflexology is considered to have potential benefits in physical rehabilitation,but its efficacy in hearing restoration requires further scientific validation through rigorous clinical trials and large-scale prospective studies.展开更多
To enhance the overall performance of cyclotrimethylenetrinitramine(RDX),a modification strategy for RDX via in situ coordination with monometallic polydopamine(PDA)coatings(PDA-Fe,PDA-Cu,and PDA-Pb)was developed.The ...To enhance the overall performance of cyclotrimethylenetrinitramine(RDX),a modification strategy for RDX via in situ coordination with monometallic polydopamine(PDA)coatings(PDA-Fe,PDA-Cu,and PDA-Pb)was developed.The thermal properties of pristine RDX and its modified variants(RDX@PDA-Fe,RDX@PDA-Cu,RDX@PDA-Pb)were characterized using differential scanning calorimetry(DSC)and accelerating rate calorimetry(ARC).The impact sensitivity of these materials was evaluated via the characteristic drop-height method.The results demonstrate that PDA-metal metal coatings—formed through coordination between PDA and single metal ions(Fe^(3+),Cu^(2+),or Pb^(2+))—significantly enhance RDX′s thermal stability while attenuating its mechanical sensitivity.These coatings act as energy-absorbing barriers against external stimuli,effectively mitigating RDX′s sensitivity.Furthermore,they elevate RDX′s thermal stability by increasing its decomposition onset temperature and accelerating its decomposition kinetics.The monometallic coatings also catalyze RDX′s thermal decomposition and combustion,with Cu and Pb exhibiting particularly distinct catalytic effects.展开更多
An energetic binder based on hydroxyl-terminated polybutadiene(HTPB),doped with different ratios of nitrocellulose(NC)(10%,20%,30%,and 50%),was developed to study the effect of NC doping on the thermal decomposition b...An energetic binder based on hydroxyl-terminated polybutadiene(HTPB),doped with different ratios of nitrocellulose(NC)(10%,20%,30%,and 50%),was developed to study the effect of NC doping on the thermal decomposition behavior of a composite propellant(CP)comprising ammonium nitrate(AN)as an oxidizer and magnesium(Mg)as a fuel.Optimization of the propellant formulation was conducted using Chemical Equilibrium with Applications-National Aeronautics and Space Administration(CEA-NASA)software,which demonstrated an increase in specific impulse by 12.09 s when the binder contained 50%NC.Fourier-transform infrared spectroscopy(FTIR)analysis confirmed the excellent compatibility between the components,and density measurements revealed an increase of 6.4%with a higher NC content.Morphological analysis using optical microscopy showed that NC doping improved the uniformity and compactness of the surface,reduced cavities,and achieved a more homogeneous particle distribution.Differential scanning calorimetry(DSC)analysis indicated a decrease in the decomposition temperature of the propellant as the NC content increased,while kinetic studies revealed a 48.68%reduction in the activation energy when 50%NC was incorporated into the binder.These findings suggest that the addition of NC enhances combustion efficiency and improves overall propellant performance.This study highlights the potential of the new HTPB-NC energetic binder as a promising approach for advancing solid propellant technology.展开更多
Sediment particles,as one of the key components of drip irrigation technology,significantly affect the service life of emitters and restrict the popularization of drip irrigation technology.Hence,two types of patch dr...Sediment particles,as one of the key components of drip irrigation technology,significantly affect the service life of emitters and restrict the popularization of drip irrigation technology.Hence,two types of patch drip irrigation emitters,focusing on the anti-clogging performance through the experiment,were investigated.The dynamic variations in the clogging characteristics of emitters,specifically were subjected to statistical analysis.The movement mechanism of emitter clogging and discharging sediment was studied.The effects of emitter structure and position factors on emitter clogging were analyzed.The results show that the pressure-compensated emitter exhibits superior anti-clogging perfor-mance,with a service life that is 227.8%greater than that of the labyrinth channel emitter.A single structural factor cannot completely evaluate the anti-clogging performance of emitters.All factors causing emitter clogging should be considered comprehensively.Emitters contain sensitive sediment prone to clogging,however,significant blockage occurs primarily when the sediment content is elevated.The discharge of sediment,denoted as V90,from the emitter is affected by the accumulative effect of clogged sediment.These results may offer valuable insights for the application and advancement of drip irrigation technology.展开更多
Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased ph...Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased physical activity(PA)are important contributors to the rising prevalence of DM.This article reviews the research progress on the pathogenesis of DM,the effects of SB and PA on the risk of DM,aiming to explore the influence of different PA intensities,amounts,frequencies,durations and types on the incidence of DM.Research has shown that blood glucose levels tend to increase with the prolongation of SB.Within a certain range,PA intensity and PA amount are negatively correlated with the risk of DM;Performing PA for more than 3 days per week maintains normal glucose tolerance and lower blood pressure;Engaging in 150–300 min of moderate intensity exercise or 75–150 min of high-intensity exercise per week reduces the risk of DM;PA during leisure time reduces the risk of DM,while PA during work increases the risk of DM;Both aerobic training and resistance training reduce the risk of DM,and the combination of the two training methods produces better benefits;Various types of exercises,such as cycling,soccer,aerobics,yoga,tai chi,all reduce the risk of DM.In summary,prolonged SB increases the risk of DM,while appropriate PA reduces the risk of DM.As the intensity,amount,and frequency of PA increase,the effect of reducing DM risk becomes more significant.Different exercise methods have different effects on reducing DM risk.展开更多
Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics...Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics,metallic nanoparticles and antimicrobial peptides,have been extensively used to deal with Ti implant infections.However,these chemical approaches suffer from potential toxicity,antibiotic resistance and poor long-term antibacterial performance.Hence,physical antibacterial surfaces on Ti-based implants have attracted increasing attention.The antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves(e.g.,nanotopography)or exogenous physical stimulus(e.g.,photocatalysis)was reviewed,as well as parameters influencing the physical antibacterial processes,such as size,shape and density of the surface nanotextures,and bacterial growth phases.Besides,mechanisms of different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials were also summarized.展开更多
Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transit...Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.展开更多
基金funded in part by the German Research Foundation(Grant reference:496846758).
文摘The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.
文摘BACKGROUND While existing literature on ischiofemoral impingement syndrome(IFI)predominantly emphasizes surgical interventions or generalized physical therapy approaches,there remains a paucity of evidence regarding structured,multimodal rehabilitation programs targeting biomechanical deficits in IFI.This case report evaluates the efficacy of a multimodal rehabilitation program addressing a critical gap in conservative management strategies.CASE SUMMARY The patient underwent comprehensive physical and clinical examination,including hip X-ray and magnetic resonance imaging investigations.The patient completed the Musculoskeletal Health Questionnaire(MSK-HQ)and numerical pain rating scale(NPRS).The patient underwent a two-month tailored structured physical therapy intervention and repeated the same assessment afterwards.The patient's substantial reduction in pain,reflected by a significant decrease in the patient’s NPRS score from 9 to 3 points,signifies a positive clinical response.This outcome,coupled with the significant improvement in the patient's health-related quality of life according to the MSK-HQ score,which increased from 12 to 48 points,underscores the success of our research.CONCLUSION The study highlights the importance of a comprehensive approach to diagnosing and managing IFI,combining clinical assessment with imaging and implementing a multimodal rehabilitation program for optimal outcomes.
文摘Beishan Rock Carvings in Chongqing,a renowned cultural heritage site in China,flourished during the Tang and Song dynasties and are often referred to as the“Stone Carving Art Museum of the Tang and Song Dynasties.”Cave 168 is a key component of the Beishan Rock Carvings.At present,several through-going cracks have developed in the roof of Cave 168,severely compromising the structural stability of the grotto.The early internal steel plate supports have suffered severe corrosion and can no longer provide effective reinforcement.In addition,the presence of steel columns obstructs visitor access and negatively affects the viewing experience.A new reinforcement method is urgently needed.Therefore,studying the deformation patterns of the structure is of critical importance.This study analyzes the stratigraphic parameters and fracture distribution of Cave 168,considering key influencing factors such as rainfall,self-weight,and the overlying Quaternary soil.On-site monitoring and physical model experiments were conducted to evaluate the changes in roof crack width and displacement before and after reinforcement with negative Poisson's ratio(NPR)anchor cables.The results reveal that the roof of Cave 168 contains several through-going cracks and numerous microcracks,which serve as infiltration channels for surface water.These accelerate the softening of the mudstone and pose a significant threat to the cave's structural safety.During the experiment,the main change in the crack exhibited a“semi-archshaped”propagation pattern.In the first ten minutes,as the rock transitioned from dry to moist conditions,a slight crack closure was observed.As rainfall continued,crack propagation accelerated.After rainfall ceased,crack width remained stable over a short period.Under NPR anchor support,the influence of rainfall on roof settlement was effectively mitigated,ensuring the safety and stability of the roof.The NPR anchors successfully limited the roof settlement to within 0.3 mm and provided effective control over both total and differential settlement.These findings offer valuable insights into the application of NPR anchor cables in the conservation of grotto heritage structures.
文摘It explores the integration of rehabilitation and palliative care in cancer management,advocating for a holistic approach that addresses the diverse needs of patients throughout their treatment journey.Traditional cancer care often prioritizes curative interventions at the expense of overall well-being,leading to a fragmented experience for patients.By combining rehabilitation-focused on restoring function and improving physical health-with palliative care-emphasizing symptom management and quality of life-healthcare providers can create a comprehensive support system.The essay highlights the importance of interdisciplinary collaboration among healthcare professionals,as well as the need for education and training to implement this integrated model effectively.Additionally,it addresses potential barriers such as funding limitations and institutional resistance.Ultimately,the integration of these two disciplines represents a critical evolution in cancer care,enhancing patient outcomes and ensuring that individuals receive compassionate,patient-centered support throughout their journey.
基金support from the National Natural Science Foundation of China (Grant Nos.51927807,42077267 and 42277174).
文摘A complex geological environment with faults can be encountered in the process of coal mining.Fault activation can cause instantaneous structure slipping,releasing a significant amount of elastic strain energy during underground coal mining.This would trigger strong rockburst disasters.To understand the occurrence of fault-slip induced rockbursts,we developed a physical model test system for fault-slip induced rockbursts in coal mine drifts.The boundary energy storage(BES)loading apparatus and bottom rapid retraction(BRR)apparatus are designed to realize energy compensation and continuous boundary stress transfer of the surrounding rocks for instantaneous fault slip,as well as to provide space for the potential fault slip.Taking the typical fault-slip induced rockburst in the Xinjulong Coal Mine,China,as the background,we conducted a model test using the test system.The deformation and stress in the rock surrounding the drift and the support unit force during fault slip are analyzed.The deformation and failure characteristics and dynamic responses of drifts under fault-slip induced rockbursts are obtained.The test results illustrate the rationality and effectiveness of the test system.Finally,corresponding recommendations and prospects are proposed based on our findings.
文摘BACKGROUND Long-term chemotherapy for patients with gastric cancer(GC),facilitated by peripherally inserted central catheter(PICC)catheterization,reduces vascular damage and enhances drug delivery efficiency but carries risks of catheter-related complications.A combination of group psychological nursing and physical mo-vement care significantly mitigates the risk of venous thrombosis and improves psychological well-being,and enhances motor function,underscoring its clinical importance.AIM To assess group psychological and physical movement nursing in preventing venous thrombosis in patients with PICC GC.METHODS Sixty-five GC patients with PICC,admitted from January 2022 to January 2023,were randomly divided into two groups using the lottery method:A control group(n=35,routine nursing)and an observation group(n=30,routine nursing plus psychological nursing and physical movement nursing).Both groups re-ceived continuous care for 2 weeks.Pre-nursing and post-nursing data on psycho-logical state,physical function,chemotherapy-related thrombosis incidence,and cancer-related fatigue were analyzed using SPSS 26.0 and GraphPad Prism 8.0.RESULTS After nursing,both groups showed reduced Hamilton Anxiety Scale scores and increased General Perceived Self-Efficacy Scale scores,with the observation group performing better(P<0.05).The Functional Comprehensive Assessment score for the observation group after nursing was(65.42±2.35)points,lower than the control group’s(62.19±4.33)points(P<0.05).Although no significant difference was observed in the incidence of venous thrombosis between the two groups(χ2=0.815,P=0.367),the observation group had lower incidence.Both groups showed decreased Revised Piper Fatigue Scale scores,with the observation group scoring lower(P<0.05).CONCLUSION Group psychological and physical movement nursing for patients with PICC reduces venous thrombosis risk,improves psychological well-being,cancer-related fatigue,and physical function,making it highly promotable.
基金Funded by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia(Nos.451-03-47/2023-01/200135,451-03-47/2023-01/200017 and 451-03-47/2023-01/200287)。
文摘This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic biomaterials.During the SPD process,a solid material sample is subjected to very high loads without a significant change in sample dimensions.In the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more detail.Considering that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is given.Moreover,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.
文摘This article comments on the work by Soresi and Giannitrapani.The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease(MASLD)is the use of glucagon-like peptide 1 receptor agonists,especially when used in combination therapy.However,despite their notable efficacy,these drugs were not initially designed to target MASLD directly.In a groundbreaking development,the Food and Drug Administration has recently approved resmetirom,the first treatment specifically aimed at reducing liver fibrosis in metabolic-associated steatohepatitis.Resmetirom,an orally administered,liver-directed thyroid hormone beta-selective agonist,acts directly on intrahepatic pathways,enhancing its therapeutic potential and marking the beginning of a new era in the treatment of MASLD.Furthermore,the integration of lifestyle modifications into liver disease management is an essential component that should be considered and reinforced.By incorporating dietary changes and regular physical exercise into treatment,patients may achieve improved outcomes,reducing the need for pharmacological interventions and/or improving treatment efficacy.As a complement to medical therapies,lifestyle factors should not be overlooked in the broader strategy for managing MASLD.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
基金supported by Project of the Health Shanghai Initiative Special Fund(Medical-Sports Integration,Creating a New Model of Exercise for Health),No.JKSHZX-2022-02(to SC).
文摘Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural regeneration.The role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of SUMOylation.We used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other cancers.We demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by nutlin-3.This underscores the intricate relationship between natural compounds such as nutlin-3 and immune regulation.Using comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma progression.We also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic simulation.Nutlin-3a inhibited glioma cell proliferation and activated the p53 pathway.Its efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or exercise.Experiments using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway regulation.Notably,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing cells.These results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma management.Our research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.
基金supported by the Major Science and Technology Project of Zhongshan City(No.2022AJ004)the Key Basic and Applied Research Program of Guangdong Province(Nos.2019B030302010 and 2022B1515120082)Guangdong Science and Technology Innovation Project(No.2021TX06C111).
文摘In general,the rapid growth of α-Fe clusters is a challenge in high Fe-content Fe-based amorphous alloys,negatively affecting their physical properties.Herein,we introduce an efficient and rapid post-treatment technique known as ultrasonic vibration rapid processing(UVRP),which enables the formation of high-density strong magnetic α-Fe clusters,thereby enhancing the soft magnetic properties of Fe_(78)Si(13)B_(9) amorphous alloy ribbon.
文摘The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by physical attacks,EMP(electromagnetic pulse)events,or cyberattacks,such disruptions could cripple essential services like water supply,healthcare,communication,and transportation.Research indicates that an attack on just nine key substations could result in a coast-to-coast blackout lasting up to 18 months,leading to economic collapse,civil unrest,and a breakdown of public order.This paper explores the key vulnerabilities of the grid,the potential impacts of prolonged blackouts,and the role of AI(artificial intelligence)and ML(machine learning)in mitigating these threats.AI-driven cybersecurity measures,predictive maintenance,automated threat response,and EMP resilience strategies are discussed as essential solutions to bolster grid security.Policy recommendations emphasize the need for hardened infrastructure,enhanced cybersecurity,redundant power systems,and AI-based grid management to ensure national resilience.Without proactive measures,the nation remains exposed to a catastrophic power grid failure that could have dire consequences for society and the economy.
基金supported by China Postdoctoral Science Foundation(2022M722674)Peixian Science and Technology Plan Project(P202410)Xuzhou Medical Reserve Talents Project(XWRCHT20220009).
文摘Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.
文摘Early intervention for sensorineural hearing loss(SNHL)in childhood is crucial for auditory and language development.In recent years,innovative auditory stimulation techniques and speech therapy strategies,such as middle ear implants,cochlear implants,auditory brainstem implants,and midbrain implants,have provided new avenues for improving patient outcomes.Additionally,basic research advancements in cell reprogramming and regeneration,stem cell therapy,and targeted drug delivery offer promising approaches to meet the individualized needs of children with SNHL.However,many challenges and unresolved issues remain in the treatment of SNHL.This article comments on the case report,which describes a female pediatric patient with SNHL who underwent foot reflexology which led to the normalization of hearing thresholds.Reflexology is considered to have potential benefits in physical rehabilitation,but its efficacy in hearing restoration requires further scientific validation through rigorous clinical trials and large-scale prospective studies.
基金National Natural Science Foundation of China(No.22405249)Open Project of Key Laboratory of Rubber Research Institute,Chinese Academy of Tropical Agricultural Science in 2025(No.RRI-KLOF202402)。
文摘To enhance the overall performance of cyclotrimethylenetrinitramine(RDX),a modification strategy for RDX via in situ coordination with monometallic polydopamine(PDA)coatings(PDA-Fe,PDA-Cu,and PDA-Pb)was developed.The thermal properties of pristine RDX and its modified variants(RDX@PDA-Fe,RDX@PDA-Cu,RDX@PDA-Pb)were characterized using differential scanning calorimetry(DSC)and accelerating rate calorimetry(ARC).The impact sensitivity of these materials was evaluated via the characteristic drop-height method.The results demonstrate that PDA-metal metal coatings—formed through coordination between PDA and single metal ions(Fe^(3+),Cu^(2+),or Pb^(2+))—significantly enhance RDX′s thermal stability while attenuating its mechanical sensitivity.These coatings act as energy-absorbing barriers against external stimuli,effectively mitigating RDX′s sensitivity.Furthermore,they elevate RDX′s thermal stability by increasing its decomposition onset temperature and accelerating its decomposition kinetics.The monometallic coatings also catalyze RDX′s thermal decomposition and combustion,with Cu and Pb exhibiting particularly distinct catalytic effects.
文摘An energetic binder based on hydroxyl-terminated polybutadiene(HTPB),doped with different ratios of nitrocellulose(NC)(10%,20%,30%,and 50%),was developed to study the effect of NC doping on the thermal decomposition behavior of a composite propellant(CP)comprising ammonium nitrate(AN)as an oxidizer and magnesium(Mg)as a fuel.Optimization of the propellant formulation was conducted using Chemical Equilibrium with Applications-National Aeronautics and Space Administration(CEA-NASA)software,which demonstrated an increase in specific impulse by 12.09 s when the binder contained 50%NC.Fourier-transform infrared spectroscopy(FTIR)analysis confirmed the excellent compatibility between the components,and density measurements revealed an increase of 6.4%with a higher NC content.Morphological analysis using optical microscopy showed that NC doping improved the uniformity and compactness of the surface,reduced cavities,and achieved a more homogeneous particle distribution.Differential scanning calorimetry(DSC)analysis indicated a decrease in the decomposition temperature of the propellant as the NC content increased,while kinetic studies revealed a 48.68%reduction in the activation energy when 50%NC was incorporated into the binder.These findings suggest that the addition of NC enhances combustion efficiency and improves overall propellant performance.This study highlights the potential of the new HTPB-NC energetic binder as a promising approach for advancing solid propellant technology.
基金National Natural Science Foundation of China(52269011,52469008)。
文摘Sediment particles,as one of the key components of drip irrigation technology,significantly affect the service life of emitters and restrict the popularization of drip irrigation technology.Hence,two types of patch drip irrigation emitters,focusing on the anti-clogging performance through the experiment,were investigated.The dynamic variations in the clogging characteristics of emitters,specifically were subjected to statistical analysis.The movement mechanism of emitter clogging and discharging sediment was studied.The effects of emitter structure and position factors on emitter clogging were analyzed.The results show that the pressure-compensated emitter exhibits superior anti-clogging perfor-mance,with a service life that is 227.8%greater than that of the labyrinth channel emitter.A single structural factor cannot completely evaluate the anti-clogging performance of emitters.All factors causing emitter clogging should be considered comprehensively.Emitters contain sensitive sediment prone to clogging,however,significant blockage occurs primarily when the sediment content is elevated.The discharge of sediment,denoted as V90,from the emitter is affected by the accumulative effect of clogged sediment.These results may offer valuable insights for the application and advancement of drip irrigation technology.
基金Key Project of Undergraduate Teaching Reform Research of Shandong Normal University(No.2024ZJ12)sixth batch of"Sports and Health"special topic of Education Research of Chinese Society of Education。
文摘Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased physical activity(PA)are important contributors to the rising prevalence of DM.This article reviews the research progress on the pathogenesis of DM,the effects of SB and PA on the risk of DM,aiming to explore the influence of different PA intensities,amounts,frequencies,durations and types on the incidence of DM.Research has shown that blood glucose levels tend to increase with the prolongation of SB.Within a certain range,PA intensity and PA amount are negatively correlated with the risk of DM;Performing PA for more than 3 days per week maintains normal glucose tolerance and lower blood pressure;Engaging in 150–300 min of moderate intensity exercise or 75–150 min of high-intensity exercise per week reduces the risk of DM;PA during leisure time reduces the risk of DM,while PA during work increases the risk of DM;Both aerobic training and resistance training reduce the risk of DM,and the combination of the two training methods produces better benefits;Various types of exercises,such as cycling,soccer,aerobics,yoga,tai chi,all reduce the risk of DM.In summary,prolonged SB increases the risk of DM,while appropriate PA reduces the risk of DM.As the intensity,amount,and frequency of PA increase,the effect of reducing DM risk becomes more significant.Different exercise methods have different effects on reducing DM risk.
基金National Natural Science Foundation of China(52171114)。
文摘Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics,metallic nanoparticles and antimicrobial peptides,have been extensively used to deal with Ti implant infections.However,these chemical approaches suffer from potential toxicity,antibiotic resistance and poor long-term antibacterial performance.Hence,physical antibacterial surfaces on Ti-based implants have attracted increasing attention.The antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves(e.g.,nanotopography)or exogenous physical stimulus(e.g.,photocatalysis)was reviewed,as well as parameters influencing the physical antibacterial processes,such as size,shape and density of the surface nanotextures,and bacterial growth phases.Besides,mechanisms of different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials were also summarized.
基金supported by The Shenzhen Educational Research Funding(zdzb2014)The Shenzhen Science and Technology Innovation Commission(202307313000096)+4 种基金The Social Science Foundation from the China's Ministry of Education(23YJA880093)The Post-Doctoral Fellowship(2022M711174)The National Center for Mental Health(Z014)BC is supported by the Chaires de recherche Rennes Métropole(23C 0909)SM is supported by the National Insti-tutes of Health(R01AG72445).
文摘Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.
