A tunable frequency-multiplying optoelectronic oscillator(OEO) based on a dual-parallel Mach-Zehnder modulator(DPMZM) is proposed and experimentally demonstrated. In the proposed system, the tunable fundamental microw...A tunable frequency-multiplying optoelectronic oscillator(OEO) based on a dual-parallel Mach-Zehnder modulator(DPMZM) is proposed and experimentally demonstrated. In the proposed system, the tunable fundamental microware signal is generated by a tunable optoelectronic oscillator incorporating a phase-shifted fiber Bragg grating(PS-FBG). By adjusting the DC bias of the DPMZM, the frequency-doubled microwave signal with a tunable frequency range from 11 GHz to 20 GHz and the frequency-quadrupled microwave signal with a tunable frequency range from 22.5 GHz to 26 GHz are generated. The phase noises of the fundamental, frequency-doubled and frequency-quadrupled signals at 10 k Hz offset frequency are-105.9 d Bc/Hz,-103.3 d Bc/Hz and-86.2 d Bc/Hz, respectively.展开更多
Using the matrix approach,we analyzed the relation between the location of the transmission in stop band and the phase shift,and discussed the problem of varying the bandwidth of the transmission window.These theoreti...Using the matrix approach,we analyzed the relation between the location of the transmission in stop band and the phase shift,and discussed the problem of varying the bandwidth of the transmission window.These theoretical results in this paper have important significance for actual application of the phase-shifted fiber grating.展开更多
By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge ...By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge zero voltage switching DC/DC converter is proposed. The converter efficiency is maximized due to soft switching of the full bridge MOSFETs and the synchronous MOSFETs, and also the low conduction loss of synchronous MOSFET. The operation principles of the circuit are analyzed in detail and the small-signal model is derived, also the converter dynamic characteristics are analyzed. Frequency responses of transfer functions under different values of transformer primary leakage inductance are discussed. The experimental results were obtained from a 400 V input and 100 A/12 V output DC/DC converter operating at 100 kHz. The results show that the converter efficiency is 2% higher in rated power than traditional diode rectifier.展开更多
The full-bridge converters usually use transformer leakage inductance and parallel resonant capacitors to achieve smooth current commutation and soft switching functions,which can easily cause problems such as energy ...The full-bridge converters usually use transformer leakage inductance and parallel resonant capacitors to achieve smooth current commutation and soft switching functions,which can easily cause problems such as energy leakage and significant duty cycle loss.This paper designs a novel full-bridge zero-current(FB-ZCS)converter with series resonant capacitors and proposes a frequency and phase-shift synthesis modulation(FPSSM)control strategy based on this topology.Compared with the traditional parallel resonant capacitor circuit,the passive components used are significantly reduced,the structure is simple,and there is only a slight energy loss.By controlling the charging time of the capacitor,it can be achieved without additional switches or auxiliary circuits.The automatic control of capacitor energy based on input current addresses the low efficiency of the traditional control strategies.This paper introduces its principle in detail and verifies it through simulation.Finally,an experimental prototype was built further to demonstrate the feasibility of the theory through experiments.The module can be applied to a photovoltaic DC collection system using input parallel output series(IPOS)cascade to provide a new topology for large-scale,long-distance DC transmission.展开更多
This paper presents a unique novel design of the phase-shifted cascade high voltage inverter. Thehigh voltage inverter utilizes fewer power switches and supplies a balance load. The usage of phase shifttransformer and...This paper presents a unique novel design of the phase-shifted cascade high voltage inverter. Thehigh voltage inverter utilizes fewer power switches and supplies a balance load. The usage of phase shifttransformer and phase shifting SPWM ensures that input and output harmonic wave content is low and outputvoltage change (du/dt) has a low rate, meeting all the requirements of the power authorities. The most out-standing feature is the energy saving with very fast cost recovery.展开更多
Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially...Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially among patients with poor functional outcomes.ICH is often accompanied by decreased consciousness and limb dysfunction.This seriously affects patients’ability to live independently.Although rapid advances in neurosurgery have greatly improved patient survival,there remains insufficient evidence that surgical treatment significantly improves long-term outcomes.With in-depth pathophysiological studies after ICH,increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after ICH.In basic and clinical studies of various systemic inflammatory diseases,triggering receptor expressed on myeloid cells 1/2(TREM-1/2),and the TREM receptor family is closely related to the inflammatory response.Various inflammatory diseases can be upregulated and downregulated through receptor intervention.How the TREM receptor functions after ICH,the types of results from intervention,and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are unknown.An analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response,significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage,and thus improve the ability of patients to live independently.展开更多
Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interac...Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.展开更多
Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this...Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this end,a dynamic high gain is introduced to cope with the influence of large uncertainties,the unknown measurement sensitivity and the execution error,while a time-varying threshold event-triggering mechanism is constructed to effectively exclude the Zeno phenomenon.As such,the adaptive event-triggered control ensures globally bounded and convergent of system states.The design method is demonstrated using a controlled pendulum example.展开更多
The earthquake early warning system is an effective means of disaster reduction to reduce losses caused by earthquakes,it can release earthquake warning information to the public before destructive seismic waves reach...The earthquake early warning system is an effective means of disaster reduction to reduce losses caused by earthquakes,it can release earthquake warning information to the public before destructive seismic waves reach the warning target area,and carry out automatic disposal of lifeline engineering facilities.Through the construction of the National Earthquake Intensity Rapid Reporting and Early Warning Project,an earthquake early warning network consisting of over 1900 monitoring stations has been established in the Beijing-Tianjin-Hebei Urban Agglomeration.The early warning system has achieved second level earthquake warning and minute level intensity rapid reporting.The implementation of these functions relies on the system's ability to timely,accurately,and reliably identify seismic waves.But with the development of social economy,the background noise of earthquake observation environment is becoming increasingly complex,which brings certain challenges to earthquake wave recognition,some interference events have the risk of triggering the earthquake warning system incorrectly.Therefore,this article focuses on seismic wave recognition in complex noise environments and proposes a seismic wave detection method based on triangulation to enhance the antiinterference ability and recognition accuracy of early warning systems.展开更多
This study utilizes data from a 3D lightning location system,polarimetric radar,and current measurements from channels of triggered lightning flashes(TLFs)to analyze the structural characteristics of the parent thunde...This study utilizes data from a 3D lightning location system,polarimetric radar,and current measurements from channels of triggered lightning flashes(TLFs)to analyze the structural characteristics of the parent thunderstorms associated with negative TLFs in South China.The triggered-flash region(TFR)displays distinct stratiform cloud characteristics,including lower radar reflectivity heights and a predominance of ice crystals and dry snow above the 0℃ layer.In contrast,the thunderstorm convection core region(CCR)tends to have more graupel particles in the mixed-phase layers and exhibits an ice-water content peak approximately 3.4 times that of the TFR.The charge regions involved in discharges in TFRs exhibit a dipolar charge structure,with the-5℃ layer roughly dividing the upper positive and lower negative charge regions.Conversely,the CCRs feature a typical tripolar charge structure.The dominant dipole charge structure in the TFR results in an increase in the negative charge field below the negative charge region with height,providing a necessary condition for successfully triggering negative TLFs.Furthermore,the horizontal extent of TLFs is positively correlated with their duration and charge transfer.Regions where TLF channels with larger charge transfers propagate tend to have greater maximum radar reflectivity but lower average radar reflectivity compared to regions with TLFs with smaller charge transfer.展开更多
Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain...Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain poorly understood.In this study,finite element method-based numerical simulations were conducted based on the rock slope at Dagangshan Hydropower Station in Sichuan province,China.Firstly,systematic analysis in both the time and frequency domains were performed to examine the seismic dynamic characteristics of the slope.Subsequently,the transfer function method and the multiple stepwise linear regression method were employed to clarify the underlying mechanism and determine critical factors influencing the slope instability during earthquakes.Time-domain analysis reveals that rock slope dynamic response exhibits notable elevation,surface,and local amplification effects.Specifically,the Peak Ground Acceleration(PGA)amplification coefficient(MPGA)is significantly higher at elevated locations,near the slope surface and in areas with protrusions.Moreover,the existence of fracture zones and anti-shear galleries minimally influences the dynamic responses but considerably affect the rupture.Specifically,fracture zones exacerbate rupture,while anti-shear galleries mitigate it.Frequency-domain analysis indicates that the dynamic responses of the slope are closely correlated with the degree of slope rupture.As earthquake magnitude increases,the rupture degree of the slope intensifies,and the dominant frequency of the response within the slope decreases,e.g.,its value shifts from 3.63 to 2.75 Hz at measurement point 9near the slope surface.The transfer function of rock slope,calculated under the excitation of wide flat spectrum white noise can reflect the interrelationships between the inherent properties and the rupture degree.Notably,the peak of the transfer function undergoes inversion as the degree of rupture increases.Furthermore,through multiple stepwise linear regression analysis,four key factors influencing the surface dynamic response of the slope were identified:rock strength,slope angle,elevation,and seismic dominant frequency.These findings provide valuable insights into the underlying mechanisms of rock slope dynamic responses triggered by earthquakes,offering essential guidance for understanding and mitigating seismic impacts on rock slopes.展开更多
Surge-type glaciers are widely developed in mountainous areas around the world.Understanding the trigger mechanism of glacier surge is a prerequisite for addressing their impacts on hydrological assessments,disentangl...Surge-type glaciers are widely developed in mountainous areas around the world.Understanding the trigger mechanism of glacier surge is a prerequisite for addressing their impacts on hydrological assessments,disentangling climate-glacier linkages,and mitigating downstream hazards.Most glacier surges occur in the compound glaciers;however,attention paid to the trigger mechanisms of such surges is minimal.This study confirmed two surges in the northern and southern branches of the Aru-4 glacier,respectively,in the Western Tibetan Plateau,using multisource remote sensing data.The northern branch of the Aru-4 glacier entered the active phase in 1999 and the active phase lasted for 6 years.The southern branch of the Aru-4 glacier entered the active phase in 2007 and the active phase lasted for 9 years.The southern branch of the Aru-4 glacier experienced a long period of retreat before the northern branch surged and their tongues were in a detached state.The northern branch surge carried a large amount of ice to the frontal area,blocking the downward transport of ice from the southern branch and initiated surge.Through the analysis of two surge processes of Aru-4 glacier,we found a new surge mechanism for compound glaciers.It was revealed that surges in such glaciers are not only triggered by the reduction in basal sliding resistance caused by the internal factors.These surges initiated in the upper part of the glacier then propagated to down glacier by intense compression force.Furthermore,surges can also be triggered by external intervention of blocking by other branches.This external trigger initiates the surge in the lower part of the glacier then propagated to the upper part by longitudinal traction force.In addition,comparing with the surge triggered by the internal factors,the surge triggered by the external intervention may have a more dramatic process.展开更多
The release of accumulated stress through earthquakes is known to devote to the mud volcanism occurrence,which may in turn affect subsequent regional seismicity.Mud volcanoes have been observed on the northeast contin...The release of accumulated stress through earthquakes is known to devote to the mud volcanism occurrence,which may in turn affect subsequent regional seismicity.Mud volcanoes have been observed on the northeast continental margin of the South China Sea as well.Based on the mud volcanoes and earthquakes catalogue,we measured the spatial and temporal distribution of z and b values,to explore the geodynamic process of the repeated eruptions of mud volcanoes influence on the regional seismicity.The results suggest a close correlation between the b-z values and mud volcanism occurrence in the SW Taiwan.Generally,the z-value anomalies in where the mud volcanoes eruptions show unchanged negative values and indicate seismic quiescence before a big earthquake,whereas the b-values often show periodicity fluctuations around the value of 0.5.This may indicate a mutual triggering relationship between the mud volcanoes and earthquakes.We infer that mud volcano eruptions help to partition and release part of the regional stress accumulation from the seismogenic structures,thus balancing the local stress and mitigating large-magnitude seismicity occurring probability.展开更多
Earthquakes not only release the long-term accumulated stress on the seismogenic fault but may also increase the stress on some surrounding faults or other segments of the seismogenic fault,thereby raising the seismic...Earthquakes not only release the long-term accumulated stress on the seismogenic fault but may also increase the stress on some surrounding faults or other segments of the seismogenic fault,thereby raising the seismic risk on these faults.This study investigates the impact of the April 2,2024,Mw 7.4 earthquake in Hualien,Taiwan,China,on the surrounding faults and aftershocks.We analyze stress-triggering effects by calculating Coulomb stress changes(ΔCFS)using rupture models and focal mechanism data.Historical focal mechanism nodal planes serve as receiver fault parameters forΔCFS calculations.Our findings indicate signifi cant Coulomb stress loading on the Longitudinal Valley fault and Central Range structure due to the mainshock,promoting their seismic activity.Loading effects vary by fault type,with thrust and strike-slip faults experiencing more stress loading than normal and odd faults.Conversely,the rupture’s coseismic slip concentration area shows predominant stress unloading,inhibiting seismic activity in the region.Aftershocks mainly experience increasedΔCFS,suggesting that the stress-triggering induced by the mainshock considerably influences the earthquake sequence evolution.These insights are crucial for understanding aftershock patterns and enhancing seismic hazard assessments.展开更多
BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the sear...BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the search for more effective therapeutic strategies critically important.Latent myofascial trigger points(MTrPs)injection,as an emerging minimally invasive treatment method,has shown potential in alleviating muscle pain and improving function,but its application in FGIDs remains insufficiently validated.AIM To assess improvements in gastrointestinal symptom severity,quality of life indices,and treatment-related adverse events between the two therapeutic approaches.METHODS This single-blind randomized controlled study recruited 60 FGIDs patients from Qilu Hospital of Shandong University,randomly divided into an injection group(TI group)and an oral medication group(PO group)at a 1:1 ratio.The TI group received abdominal wall latent MTrPs injection therapy,while the PO group received oral symptomatic medication treatment.Primary outcome measures were gastrointestinal symptom severity scores(Gastrointestinal Symptom Rating Scale,Irritable Bowel Syndrome Severity Scoring System scales)at 2 weeks and 4 weeks after treatment completion.Secondary outcome measures included Gastrointestinal Quality of Life Index scores.Both groups underwent rigorous follow-up and assessment.RESULTS The TI group is anticipated to significantly outperform the PO group in gastrointestinal symptom relief and quality of life improvement.TI group patients are expected to show a notable decrease in symptom scores,increased quality of life index,and higher clinical effectiveness rate.Additionally,the TI group is projected to have a low adverse event rate and good safety profile.CONCLUSION Latent MTrPs injection therapy may represent an effective and safe new method for treating FGIDs.Compared to traditional oral medication treatment,this method demonstrates significant advantages in improving patient symptoms and quality of life.展开更多
Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellula...Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.展开更多
Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous sta...Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.展开更多
Dear Editor,This letter deals with the stabilization of a resilient model predictive control(MPC)algorithm with a dynamic event-triggered mechanism subject to Denial-of-Service(Do S)attacks.Different from previous wor...Dear Editor,This letter deals with the stabilization of a resilient model predictive control(MPC)algorithm with a dynamic event-triggered mechanism subject to Denial-of-Service(Do S)attacks.Different from previous works,this letter is based on the designed threshold function to dynamically trigger and gives the upper bound conditions for intersampling intervals with attack and attack-free scenarios to converge.展开更多
Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topolo...Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topologies,this method employs semi-Markov jump processes for accurate load forecasting,facilitating adaptive adjustments of distributed generators(DGs)in response to load changes.展开更多
Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To s...Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To seek the generalized Nash equilibrium(GNE),a projectionbased distributed algorithm via constant step-sizes is developed with linear convergence.In particular,a variable tracking technique is incorporated to estimate the aggregative function,and an event-triggered mechanism is designed to reduce the communication cost.Finally,a numerical example demonstrates the theoretical results.展开更多
基金supported by the National Key R&D Program of China (No.2018YFB1801003)the National Natural Science Foundation of China (Nos.61525501 and 61827817)+1 种基金the Beijing Natural Science Foundation (No.4192022)the Project of Shandong Province Higher Educational Science and Technology Program (No.J17KA089)。
文摘A tunable frequency-multiplying optoelectronic oscillator(OEO) based on a dual-parallel Mach-Zehnder modulator(DPMZM) is proposed and experimentally demonstrated. In the proposed system, the tunable fundamental microware signal is generated by a tunable optoelectronic oscillator incorporating a phase-shifted fiber Bragg grating(PS-FBG). By adjusting the DC bias of the DPMZM, the frequency-doubled microwave signal with a tunable frequency range from 11 GHz to 20 GHz and the frequency-quadrupled microwave signal with a tunable frequency range from 22.5 GHz to 26 GHz are generated. The phase noises of the fundamental, frequency-doubled and frequency-quadrupled signals at 10 k Hz offset frequency are-105.9 d Bc/Hz,-103.3 d Bc/Hz and-86.2 d Bc/Hz, respectively.
文摘Using the matrix approach,we analyzed the relation between the location of the transmission in stop band and the phase shift,and discussed the problem of varying the bandwidth of the transmission window.These theoretical results in this paper have important significance for actual application of the phase-shifted fiber grating.
文摘By using the output inductors and body capacitances without adding any component compared with hard switching synchronous rectifier,the topology of a soft switched synchronous rectifier with phase-shifted full bridge zero voltage switching DC/DC converter is proposed. The converter efficiency is maximized due to soft switching of the full bridge MOSFETs and the synchronous MOSFETs, and also the low conduction loss of synchronous MOSFET. The operation principles of the circuit are analyzed in detail and the small-signal model is derived, also the converter dynamic characteristics are analyzed. Frequency responses of transfer functions under different values of transformer primary leakage inductance are discussed. The experimental results were obtained from a 400 V input and 100 A/12 V output DC/DC converter operating at 100 kHz. The results show that the converter efficiency is 2% higher in rated power than traditional diode rectifier.
基金This work was supported by the Key R&D Program of Tianjin(No.20YFYSGX00060).
文摘The full-bridge converters usually use transformer leakage inductance and parallel resonant capacitors to achieve smooth current commutation and soft switching functions,which can easily cause problems such as energy leakage and significant duty cycle loss.This paper designs a novel full-bridge zero-current(FB-ZCS)converter with series resonant capacitors and proposes a frequency and phase-shift synthesis modulation(FPSSM)control strategy based on this topology.Compared with the traditional parallel resonant capacitor circuit,the passive components used are significantly reduced,the structure is simple,and there is only a slight energy loss.By controlling the charging time of the capacitor,it can be achieved without additional switches or auxiliary circuits.The automatic control of capacitor energy based on input current addresses the low efficiency of the traditional control strategies.This paper introduces its principle in detail and verifies it through simulation.Finally,an experimental prototype was built further to demonstrate the feasibility of the theory through experiments.The module can be applied to a photovoltaic DC collection system using input parallel output series(IPOS)cascade to provide a new topology for large-scale,long-distance DC transmission.
文摘This paper presents a unique novel design of the phase-shifted cascade high voltage inverter. Thehigh voltage inverter utilizes fewer power switches and supplies a balance load. The usage of phase shifttransformer and phase shifting SPWM ensures that input and output harmonic wave content is low and outputvoltage change (du/dt) has a low rate, meeting all the requirements of the power authorities. The most out-standing feature is the energy saving with very fast cost recovery.
基金Supported by Shanxi Provincial Key Research and Development Plan Project,No.2020ZDLSF01-02Doctor Foundation of the Second Affiliated Hospital of Xi’an Medical University,No.X2Y-R11.
文摘Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially among patients with poor functional outcomes.ICH is often accompanied by decreased consciousness and limb dysfunction.This seriously affects patients’ability to live independently.Although rapid advances in neurosurgery have greatly improved patient survival,there remains insufficient evidence that surgical treatment significantly improves long-term outcomes.With in-depth pathophysiological studies after ICH,increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after ICH.In basic and clinical studies of various systemic inflammatory diseases,triggering receptor expressed on myeloid cells 1/2(TREM-1/2),and the TREM receptor family is closely related to the inflammatory response.Various inflammatory diseases can be upregulated and downregulated through receptor intervention.How the TREM receptor functions after ICH,the types of results from intervention,and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are unknown.An analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response,significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage,and thus improve the ability of patients to live independently.
文摘Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.
基金supported by the National Natural Science Foundation of China(62203283)Shandong Provincial Natural Science Foundation(ZR2022QF009,ZR2023QA063)the China Postdoctoral Science Foundation(2022M711981).
文摘Dear Editor,This letter investigates global stabilization of uncertain nonlinear systems via adaptive event-triggered output feedback.Uncertainties lie in both system nonlinearities and measurement sensitivity.To this end,a dynamic high gain is introduced to cope with the influence of large uncertainties,the unknown measurement sensitivity and the execution error,while a time-varying threshold event-triggering mechanism is constructed to effectively exclude the Zeno phenomenon.As such,the adaptive event-triggered control ensures globally bounded and convergent of system states.The design method is demonstrated using a controlled pendulum example.
基金supported by the Spark Program of Earthquake Science and Technology(No.XH23003C)。
文摘The earthquake early warning system is an effective means of disaster reduction to reduce losses caused by earthquakes,it can release earthquake warning information to the public before destructive seismic waves reach the warning target area,and carry out automatic disposal of lifeline engineering facilities.Through the construction of the National Earthquake Intensity Rapid Reporting and Early Warning Project,an earthquake early warning network consisting of over 1900 monitoring stations has been established in the Beijing-Tianjin-Hebei Urban Agglomeration.The early warning system has achieved second level earthquake warning and minute level intensity rapid reporting.The implementation of these functions relies on the system's ability to timely,accurately,and reliably identify seismic waves.But with the development of social economy,the background noise of earthquake observation environment is becoming increasingly complex,which brings certain challenges to earthquake wave recognition,some interference events have the risk of triggering the earthquake warning system incorrectly.Therefore,this article focuses on seismic wave recognition in complex noise environments and proposes a seismic wave detection method based on triangulation to enhance the antiinterference ability and recognition accuracy of early warning systems.
基金funded by the Natural Science Foundation of China(Grant No.U2342215)Key Laboratory of South China Sea Meteorological Disaster Prevention and Mitigation of Hainan Province(Grant No.SCSF202302)。
文摘This study utilizes data from a 3D lightning location system,polarimetric radar,and current measurements from channels of triggered lightning flashes(TLFs)to analyze the structural characteristics of the parent thunderstorms associated with negative TLFs in South China.The triggered-flash region(TFR)displays distinct stratiform cloud characteristics,including lower radar reflectivity heights and a predominance of ice crystals and dry snow above the 0℃ layer.In contrast,the thunderstorm convection core region(CCR)tends to have more graupel particles in the mixed-phase layers and exhibits an ice-water content peak approximately 3.4 times that of the TFR.The charge regions involved in discharges in TFRs exhibit a dipolar charge structure,with the-5℃ layer roughly dividing the upper positive and lower negative charge regions.Conversely,the CCRs feature a typical tripolar charge structure.The dominant dipole charge structure in the TFR results in an increase in the negative charge field below the negative charge region with height,providing a necessary condition for successfully triggering negative TLFs.Furthermore,the horizontal extent of TLFs is positively correlated with their duration and charge transfer.Regions where TLF channels with larger charge transfers propagate tend to have greater maximum radar reflectivity but lower average radar reflectivity compared to regions with TLFs with smaller charge transfer.
基金supported by the National Natural Science Foundation of China(Grant Nos.52274075,42122052,52379098)。
文摘Landslides triggered by seismic activity have led to substantial human and economic losses.Nevertheless,the fundamental physical mechanisms underlying the vibration and rupture of rock slopes during earthquakes remain poorly understood.In this study,finite element method-based numerical simulations were conducted based on the rock slope at Dagangshan Hydropower Station in Sichuan province,China.Firstly,systematic analysis in both the time and frequency domains were performed to examine the seismic dynamic characteristics of the slope.Subsequently,the transfer function method and the multiple stepwise linear regression method were employed to clarify the underlying mechanism and determine critical factors influencing the slope instability during earthquakes.Time-domain analysis reveals that rock slope dynamic response exhibits notable elevation,surface,and local amplification effects.Specifically,the Peak Ground Acceleration(PGA)amplification coefficient(MPGA)is significantly higher at elevated locations,near the slope surface and in areas with protrusions.Moreover,the existence of fracture zones and anti-shear galleries minimally influences the dynamic responses but considerably affect the rupture.Specifically,fracture zones exacerbate rupture,while anti-shear galleries mitigate it.Frequency-domain analysis indicates that the dynamic responses of the slope are closely correlated with the degree of slope rupture.As earthquake magnitude increases,the rupture degree of the slope intensifies,and the dominant frequency of the response within the slope decreases,e.g.,its value shifts from 3.63 to 2.75 Hz at measurement point 9near the slope surface.The transfer function of rock slope,calculated under the excitation of wide flat spectrum white noise can reflect the interrelationships between the inherent properties and the rupture degree.Notably,the peak of the transfer function undergoes inversion as the degree of rupture increases.Furthermore,through multiple stepwise linear regression analysis,four key factors influencing the surface dynamic response of the slope were identified:rock strength,slope angle,elevation,and seismic dominant frequency.These findings provide valuable insights into the underlying mechanisms of rock slope dynamic responses triggered by earthquakes,offering essential guidance for understanding and mitigating seismic impacts on rock slopes.
基金funded by the Open Research Fund of TPESER(Grant No.TPESER202502)the National Key Research and Development Program of China(Grant No.2024YFF0810700)+3 种基金the Science and Technology Program Project of Gansu Province,China(Grant No.25JRRA138)the Hydraulic Science Experimental Research and Technology Extension Project of Gansu Province,China(Grant No.25GSLK094)the Open Foundation of MOE Key Laboratory of Western China's Environmental System,Lanzhou Universitythe Fundamental Research Funds for the Central Universities(Grant No.1zujbky-2025-jdzx02)。
文摘Surge-type glaciers are widely developed in mountainous areas around the world.Understanding the trigger mechanism of glacier surge is a prerequisite for addressing their impacts on hydrological assessments,disentangling climate-glacier linkages,and mitigating downstream hazards.Most glacier surges occur in the compound glaciers;however,attention paid to the trigger mechanisms of such surges is minimal.This study confirmed two surges in the northern and southern branches of the Aru-4 glacier,respectively,in the Western Tibetan Plateau,using multisource remote sensing data.The northern branch of the Aru-4 glacier entered the active phase in 1999 and the active phase lasted for 6 years.The southern branch of the Aru-4 glacier entered the active phase in 2007 and the active phase lasted for 9 years.The southern branch of the Aru-4 glacier experienced a long period of retreat before the northern branch surged and their tongues were in a detached state.The northern branch surge carried a large amount of ice to the frontal area,blocking the downward transport of ice from the southern branch and initiated surge.Through the analysis of two surge processes of Aru-4 glacier,we found a new surge mechanism for compound glaciers.It was revealed that surges in such glaciers are not only triggered by the reduction in basal sliding resistance caused by the internal factors.These surges initiated in the upper part of the glacier then propagated to down glacier by intense compression force.Furthermore,surges can also be triggered by external intervention of blocking by other branches.This external trigger initiates the surge in the lower part of the glacier then propagated to the upper part by longitudinal traction force.In addition,comparing with the surge triggered by the internal factors,the surge triggered by the external intervention may have a more dramatic process.
基金supported by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.SML2021SP318)the National Postdoctoral Program for Innovative Talents(No.BX20190391)+1 种基金the Guangdong Province Introduced Innovative R&D Team of Geological Processes and Natural Disasters around the South China Sea founded by the Science and Technology Department of Guangdong Province(No.2016ZT06N331)the Guangdong Basic and Applied Basic Research Foundation(Nos.2019A1515110305,2021A1515011130,2021A1515110288)。
文摘The release of accumulated stress through earthquakes is known to devote to the mud volcanism occurrence,which may in turn affect subsequent regional seismicity.Mud volcanoes have been observed on the northeast continental margin of the South China Sea as well.Based on the mud volcanoes and earthquakes catalogue,we measured the spatial and temporal distribution of z and b values,to explore the geodynamic process of the repeated eruptions of mud volcanoes influence on the regional seismicity.The results suggest a close correlation between the b-z values and mud volcanism occurrence in the SW Taiwan.Generally,the z-value anomalies in where the mud volcanoes eruptions show unchanged negative values and indicate seismic quiescence before a big earthquake,whereas the b-values often show periodicity fluctuations around the value of 0.5.This may indicate a mutual triggering relationship between the mud volcanoes and earthquakes.We infer that mud volcano eruptions help to partition and release part of the regional stress accumulation from the seismogenic structures,thus balancing the local stress and mitigating large-magnitude seismicity occurring probability.
基金supported by the National Natural Science Foundation of China(42364005,42174074,42064008 and 41704053)Science&Technology Fundamental Resources Investigation Program(Grant No.2023FY201500)+1 种基金Science and Technology Plan Project of Jiangxi Province(20212BCJ23002,20232ACB213013)the East China University of Technology Research Foundation for Advanced Talents(ECUT)(DHBK2019084)。
文摘Earthquakes not only release the long-term accumulated stress on the seismogenic fault but may also increase the stress on some surrounding faults or other segments of the seismogenic fault,thereby raising the seismic risk on these faults.This study investigates the impact of the April 2,2024,Mw 7.4 earthquake in Hualien,Taiwan,China,on the surrounding faults and aftershocks.We analyze stress-triggering effects by calculating Coulomb stress changes(ΔCFS)using rupture models and focal mechanism data.Historical focal mechanism nodal planes serve as receiver fault parameters forΔCFS calculations.Our findings indicate signifi cant Coulomb stress loading on the Longitudinal Valley fault and Central Range structure due to the mainshock,promoting their seismic activity.Loading effects vary by fault type,with thrust and strike-slip faults experiencing more stress loading than normal and odd faults.Conversely,the rupture’s coseismic slip concentration area shows predominant stress unloading,inhibiting seismic activity in the region.Aftershocks mainly experience increasedΔCFS,suggesting that the stress-triggering induced by the mainshock considerably influences the earthquake sequence evolution.These insights are crucial for understanding aftershock patterns and enhancing seismic hazard assessments.
文摘BACKGROUND Functional gastrointestinal disorders(FGIDs)are common gastrointestinal conditions that significantly impair patient quality of life.Current clinical treatment methods are relatively limited,making the search for more effective therapeutic strategies critically important.Latent myofascial trigger points(MTrPs)injection,as an emerging minimally invasive treatment method,has shown potential in alleviating muscle pain and improving function,but its application in FGIDs remains insufficiently validated.AIM To assess improvements in gastrointestinal symptom severity,quality of life indices,and treatment-related adverse events between the two therapeutic approaches.METHODS This single-blind randomized controlled study recruited 60 FGIDs patients from Qilu Hospital of Shandong University,randomly divided into an injection group(TI group)and an oral medication group(PO group)at a 1:1 ratio.The TI group received abdominal wall latent MTrPs injection therapy,while the PO group received oral symptomatic medication treatment.Primary outcome measures were gastrointestinal symptom severity scores(Gastrointestinal Symptom Rating Scale,Irritable Bowel Syndrome Severity Scoring System scales)at 2 weeks and 4 weeks after treatment completion.Secondary outcome measures included Gastrointestinal Quality of Life Index scores.Both groups underwent rigorous follow-up and assessment.RESULTS The TI group is anticipated to significantly outperform the PO group in gastrointestinal symptom relief and quality of life improvement.TI group patients are expected to show a notable decrease in symptom scores,increased quality of life index,and higher clinical effectiveness rate.Additionally,the TI group is projected to have a low adverse event rate and good safety profile.CONCLUSION Latent MTrPs injection therapy may represent an effective and safe new method for treating FGIDs.Compared to traditional oral medication treatment,this method demonstrates significant advantages in improving patient symptoms and quality of life.
基金Supported by Henan Province's"Double First-Class"Creation of Scientific Research in Traditional Chinese Medicine,No.HSRPDFCTCM-2023-7-23 and No.STG-ZYX02-202117National Traditional Chinese Medicine Clinical Research Base Scientific Research Special Project,No.2022JDZX098 and No.2022JDZX114+1 种基金National Natural Science Foundation of China,No.82205086The 9th China Association for Science and Technology Young Talent Support Project,No.2023QNRC001.
文摘Non-alcoholic fatty liver disease(NAFLD)is a progressive disease.Without effective interventions,NAFLD can gradually develop to non-alcoholic steatohepatitis,fatty liver fibrosis,liver cirrhosis and even hepatocellular carcinoma.It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD.Triggering receptor expressed on myeloid cells 2(TREM2)can sense tissue injury and mediate immune remodeling,thereby inducing phagocytosis,lipid metabolism,and metabolic transfer,promoting cell survival and combating inflammatory activation.NAFLD might develop as a result of TREM2's regulatory role.We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD.Moreover,we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.
基金supported by the National Natural Science Foundation of China(62403393,12202058,62103118)the China Postdoctoral Science Foundation(2021T140160,2023 T160051)the Natural Science Foundation of Chongqing(CSTB 2023NSCQ-MSX0152)
文摘Dear Editor,This letter deals with the stabilization problem of nonlinear stochastic systems via self-triggered impulsive control(STIC), where the timing of impulsive control actions is not dependent on continuous state monitoring. In contrast to the existing self-triggered control method, novel self-triggered mechanism(STM) is proposed by incorporating a waiting time for stabilizing impulses. This allows for direct prediction of the next impulsive instant.
文摘Dear Editor,This letter deals with the stabilization of a resilient model predictive control(MPC)algorithm with a dynamic event-triggered mechanism subject to Denial-of-Service(Do S)attacks.Different from previous works,this letter is based on the designed threshold function to dynamically trigger and gives the upper bound conditions for intersampling intervals with attack and attack-free scenarios to converge.
基金supported by the Shandong Provincial Natural Science Foundation(ZR2023QF092)the National Natural Science Foundation of China(62373224).
文摘Dear Editor,This letter introduces an innovative event-triggered secondary control strategy for Microgrid(MG)to address challenges of low inertia and renewable energy integration.Utilizing semi-Markov switching topologies,this method employs semi-Markov jump processes for accurate load forecasting,facilitating adaptive adjustments of distributed generators(DGs)in response to load changes.
基金supported by the National Natural Science Foundation of China(62473048,61925303,62088101,62273195,U19B2029).
文摘Dear Editor,This letter studies the distributed Nash equilibrium seeking problem of aggregative game,in which the decision of each player obeys second-order dynamics and is constrained by nonidentical convex sets.To seek the generalized Nash equilibrium(GNE),a projectionbased distributed algorithm via constant step-sizes is developed with linear convergence.In particular,a variable tracking technique is incorporated to estimate the aggregative function,and an event-triggered mechanism is designed to reduce the communication cost.Finally,a numerical example demonstrates the theoretical results.
