Optical fiber optrodes are attractive sensing devices due to their ability to perform point measurement in remote locations. Mostly, they are oriented to biochemical sensing, quite often supported by fluorescent and s...Optical fiber optrodes are attractive sensing devices due to their ability to perform point measurement in remote locations. Mostly, they are oriented to biochemical sensing, quite often supported by fluorescent and spectroscopic techniques, but with the refractometric approach considered as well when the objective is of high measurement performance, particularly when the focus is on enhancing the measurand resolution. In this work, we address this subject, proposing and analyzing the characteristics of a fiber optic optrode relying on plasmonic interaction. A linearly tapered optical fiber tip is covered by a double overlay： the inner one - a silver thin film and over it - a dielectric layer, with this combination allowing to achieve, at a specific wavelength range, surface plasmonic resonance （SPR） interaction sensitive Typically, the interrogation of the SPR sensing to the refractive index of the surrounding medium. structures is performed, considering spectroscopic techniques, but in principle, a far better performance can be obtained, considering the reading of the phase of the light at a specific wavelength located within the spectral plasmonic resonance. This is the approach which is studied here in the context of the proposed optical fiber optrode configuration. The analysis performed shows the combination of a silver inner layer with a dielectric titanium oxide layer with tuned thicknesses enables sensitive phase reading and allows the operation of the fiber optic optrode sensor in the third telecommunication wavelength window.展开更多
Nanophotonics,and more specifically plasmonics,provides a rich toolbox for biomolecular sensing,since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels.So far,biosensing associ...Nanophotonics,and more specifically plasmonics,provides a rich toolbox for biomolecular sensing,since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels.So far,biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes.However,the phase response of the plasmonic resonances have rarely been exploited,mainly because this requires a more sophisticated optical arrangement.Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics.It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration.This unique combination allows the detection of atomically thin(angstrom-level)topographical features over large areas,enabling simultaneous reading of thousands of microarray elements.As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components,the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes.Our research opens new horizons for on-site disease diagnostics and remote health monitoring.展开更多
文摘Optical fiber optrodes are attractive sensing devices due to their ability to perform point measurement in remote locations. Mostly, they are oriented to biochemical sensing, quite often supported by fluorescent and spectroscopic techniques, but with the refractometric approach considered as well when the objective is of high measurement performance, particularly when the focus is on enhancing the measurand resolution. In this work, we address this subject, proposing and analyzing the characteristics of a fiber optic optrode relying on plasmonic interaction. A linearly tapered optical fiber tip is covered by a double overlay： the inner one - a silver thin film and over it - a dielectric layer, with this combination allowing to achieve, at a specific wavelength range, surface plasmonic resonance （SPR） interaction sensitive Typically, the interrogation of the SPR sensing to the refractive index of the surrounding medium. structures is performed, considering spectroscopic techniques, but in principle, a far better performance can be obtained, considering the reading of the phase of the light at a specific wavelength located within the spectral plasmonic resonance. This is the approach which is studied here in the context of the proposed optical fiber optrode configuration. The analysis performed shows the combination of a silver inner layer with a dielectric titanium oxide layer with tuned thicknesses enables sensitive phase reading and allows the operation of the fiber optic optrode sensor in the third telecommunication wavelength window.
基金funded by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No.644956(RAIS project)the North Atlantic Treaty Organization’s Public Diplomacy Division in the framework of‘Science for Peace’(NATO—SPS),École Polytechnique Fédérale de Lausanne research fund,FundacióPrivada Cellex+4 种基金the CERCA Programme/Generalitat de Catalunyasupport from the International PhD fellowship program‘la Caixa’—Severo Ochoa@ICFOsupport from the International PhD fellowship program'la Caixa'-Severo Ochoa@ICFOsupport from the Spanish Ministry of Economy and Competitiveness,through the‘Severo Ochoa’Programme for Centres of Excellence in R&D(SEV-2015-0522)project OPTO-SCREEN(TEC2016-75080-R).
文摘Nanophotonics,and more specifically plasmonics,provides a rich toolbox for biomolecular sensing,since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels.So far,biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes.However,the phase response of the plasmonic resonances have rarely been exploited,mainly because this requires a more sophisticated optical arrangement.Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics.It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration.This unique combination allows the detection of atomically thin(angstrom-level)topographical features over large areas,enabling simultaneous reading of thousands of microarray elements.As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components,the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes.Our research opens new horizons for on-site disease diagnostics and remote health monitoring.
