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Formulating an Innovative Gamified Personalized Learning Ecosystem Integrating 3D/VR Environments,Machine Learning,and Business Intelligence
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作者 Nymfodora-Maria Raftopoulou Petros L.Pallis 《Sociology Study》 2026年第1期13-32,共20页
Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalize... Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalized Learning Ecosystem,which integrates 3D/VR environments,as well as machine learning algorithms,and business intelligence frameworks to enhance learner-centered education and inferenced decision-making.This Learning System makes use of immersive,analytically assessed virtual learning spaces,therefore facilitating real-time monitoring of not just learning performance,but also overall engagement and behavioral patterns,via a comprehensive set of sustainability-oriented ESG-aligned Key Performance Indicators(KPIs).Machine learning models support predictive analysis,personalized feedback,and hybrid recommendation mechanisms,whilst dedicated dashboards translate complex educational data into actionable insights for all Use Cases of the System(Educational Institutions,Educators and Learners).Additionally,the presented Learning System introduces a structured Mentoring and Consulting Subsystem,thence reinforcing human-centered guidance alongside automated intelligence.The Platform’s modular architecture and simulation-centered evaluation approach actively support personalized,and continuously optimized learning pathways.Thence,it exemplifies a mature,adaptive Learning Ecosystem,supporting immersive technologies,analytics,and pedagogical support,hence,contributing to contemporary digital learning innovation and sociotechnical transformation in education. 展开更多
关键词 gamified learning ecosystems learning analytics business intelligence personalized education virtual reality machine learning
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Personalized Recommendation System Using Deep Learning with Bayesian Personalized Ranking
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作者 Sophort Siet Sony Peng +1 位作者 Ilkhomjon Sadriddinov Kyuwon Park 《Computers, Materials & Continua》 2026年第3期1423-1443,共21页
Recommendation systems have become indispensable for providing tailored suggestions and capturing evolving user preferences based on interaction histories.The collaborative filtering(CF)model,which depends exclusively... Recommendation systems have become indispensable for providing tailored suggestions and capturing evolving user preferences based on interaction histories.The collaborative filtering(CF)model,which depends exclusively on user-item interactions,commonly encounters challenges,including the cold-start problem and an inability to effectively capture the sequential and temporal characteristics of user behavior.This paper introduces a personalized recommendation system that combines deep learning techniques with Bayesian Personalized Ranking(BPR)optimization to address these limitations.With the strong support of Long Short-Term Memory(LSTM)networks,we apply it to identify sequential dependencies of user behavior and then incorporate an attention mechanism to improve the prioritization of relevant items,thereby enhancing recommendations based on the hybrid feedback of the user and its interaction patterns.The proposed system is empirically evaluated using publicly available datasets from movie and music,and we evaluate the performance against standard recommendation models,including Popularity,BPR,ItemKNN,FPMC,LightGCN,GRU4Rec,NARM,SASRec,and BERT4Rec.The results demonstrate that our proposed framework consistently achieves high outcomes in terms of HitRate,NDCG,MRR,and Precision at K=100,with scores of(0.6763,0.1892,0.0796,0.0068)on MovieLens-100K,(0.6826,0.1920,0.0813,0.0068)on MovieLens-1M,and(0.7937,0.3701,0.2756,0.0078)on Last.fm.The results show an average improvement of around 15%across all metrics compared to existing sequence models,proving that our framework ranks and recommends items more accurately. 展开更多
关键词 Recommendation systems traditional collaborative filtering Bayesian personalized ranking
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A Collaborative Broadcast Content Recording System Using Distributed Personal Video Recorders
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作者 Eunsam Kim Choonhwa Lee 《Computers, Materials & Continua》 2025年第2期2555-2581,共27页
Personal video recorders (PVRs) have altered the way users consume television (TV) content by allowing users to record programs and watch them at their convenience, overcoming the constraints of live broadcasting. How... Personal video recorders (PVRs) have altered the way users consume television (TV) content by allowing users to record programs and watch them at their convenience, overcoming the constraints of live broadcasting. However, standalone PVRs are limited by their individual storage capacities, restricting the number of programs they can store. While online catch-up TV services such as Hulu and Netflix mitigate this limitation by offering on-demand access to broadcast programs shortly after their initial broadcast, they require substantial storage and network resources, leading to significant infrastructural costs for service providers. To address these challenges, we propose a collaborative TV content recording system that leverages distributed PVRs, combining their storage into a virtual shared pool without additional costs. Our system aims to support all concurrent playback requests without service interruption while ensuring program availability comparable to that of local devices. The main contributions of our proposed system are fourfold. First, by sharing storage and upload bandwidth among PVRs, our system significantly expands the overall recording capacity and enables simultaneous recording of multiple programs without the physical constraints of standalone devices. Second, by utilizing erasure coding efficiently, our system reduces the storage space required for each program, allowing more programs to be recorded compared to traditional replication. Third, we propose an adaptive redundancy scheme to control the degree of redundancy of each program based on its evolving playback demand, ensuring high-quality playback by providing sufficient bandwidth for popular programs. Finally, we introduce a contribution-based incentive policy that encourages PVRs to actively participate by contributing resources, while discouraging excessive consumption of the combined storage pool. Through extensive experiments, we demonstrate the effectiveness of our proposed collaborative TV program recording system in terms of storage efficiency and performance. 展开更多
关键词 Collaborative recording TV content personal video recorder erasure coding REPLICATION
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The Mechanism of Artificial Intelligence-Empowered Personalized Learning Systems on University Students’STEM Learning Motivation and Academic Achievement:An Educational Psychology Perspective
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作者 Yingyou Meng 《Journal of Contemporary Educational Research》 2025年第10期421-427,共7页
With the continuous advancement of artificial intelligence(AI)technology,personalized learning systems are increasingly applied in higher education.Particularly within STEM(Science,Technology,Engineering,and Mathemati... With the continuous advancement of artificial intelligence(AI)technology,personalized learning systems are increasingly applied in higher education.Particularly within STEM(Science,Technology,Engineering,and Mathematics)education,AI demonstrates significant advantages through adaptive learning pathways,instant feedback,and individualized resource allocation.However,current research predominantly focuses on the technical architecture and application effectiveness of such systems,with insufficient exploration of how AI-enabled personalized learning systems influence university students’learning motivation and academic achievement through educational psychological mechanisms.This paper adopts an educational psychology perspective to construct a causal mechanism model linking“learning motivation-learning behavior-academic achievement.”Findings indicate that AI-powered personalized learning systems enhance learning autonomy,boost self-efficacy,and optimize feedback mechanisms.These effects collectively stimulate university students’learning motivation in STEM disciplines,thereby promoting academic achievement.Building upon empirical research,this paper proposes implications for educational practice and policy formulation,emphasizing the necessity of advancing higher education reform through the dual influence of technology and psychological mechanisms. 展开更多
关键词 Artificial intelligence personalized learning systems Educational psychology Learning motivation Academic achievement STEM
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Preoperative anxiety among patients and its correlation with their personality type and pain:A cross-sectional study
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作者 Nariman Salem Abdul Hadi Moursel +10 位作者 Ali Zahweh Dana Shhadi Fedaa Saad Mahdi Reda Mariam Mghames Rami Roumieh Rawan Tfaily Salim M Ramadan Bahaa Bou Dargham Omar Rajab Fatima Akel 《World Journal of Psychiatry》 2026年第1期278-290,共13页
BACKGROUND Preoperative anxiety is a significant concern for patients,as it affects surgical outcomes,satisfaction,and pain perception.Although both anxiety and pain are common in surgical settings,their relationship ... BACKGROUND Preoperative anxiety is a significant concern for patients,as it affects surgical outcomes,satisfaction,and pain perception.Although both anxiety and pain are common in surgical settings,their relationship with personality traits has not been previously investigated in the Lebanese population.AIM To examine the prevalence of preoperative anxiety,pain perception,and personality traits among Lebanese surgical patients,and to assess the associations between these factors.METHODS A descriptive cross-sectional study was conducted between April 2024 and January 2025 across Lebanese hospitals.A total of 392 adult patients were recruited through convenience sampling.Data were collected using a questionnaire that included sociodemographic,clinical,and surgical variables,the Amsterdam Preoperative Anxiety and Information Scale for anxiety,the Visual Analog Scale and Numerical Pain Rating Scale for preoperative pain,and the Ten-Item Personality Inventory for personality traits.Ethical approval was obtained from the Institutional Review Boards of Makassed General Hospital and Hammoud University Medical Center.RESULTS Overall,25%of participants experienced preoperative anxiety,and 34.5%reported moderate pain.Personality assessment showed that the majority of participants had moderate extraversion(84.1%),moderate emotional stability(65.1%),high conscientiousness(61%),high agreeableness(54.1%),and moderate openness(49.2%).High conscientiousness was significantly associated with higher pain perception(P<0.05),while high emotional stability was associated with lower levels of anxiety(P<0.05).No significant association was found between preoperative anxiety and pain(P>0.05).CONCLUSION This study challenges the assumption that preoperative anxiety and pain are directly correlated and highlights the role of personality traits in shaping patient experience.These findings support the potential value of integrating psychological profiling into preoperative care and lay the groundwork for developing personalized interventions to improve patient-centered surgical outcomes. 展开更多
关键词 Preoperative anxiety Pain perception personality traits CONSCIENTIOUSNESS Emotional stability Lebanese hospitals Surgical patients personalized care strategies
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National identity and subjective well-being among college students:A sequential mediation analysis of collective and personal self-esteem
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作者 Luming Zhao Jiaxi Zhang +1 位作者 Yan Zhang Jiaxi Peng 《Journal of Psychology in Africa》 2026年第1期1-8,共8页
The current study examined the roles of collective self-esteem and personal self-esteem in the relationship between national identity and subjective well-being.Participants were 583 Chinese college students(females=49... The current study examined the roles of collective self-esteem and personal self-esteem in the relationship between national identity and subjective well-being.Participants were 583 Chinese college students(females=49%;mean age=19.25±1.85 years).They completed measures of national identity,collective self-esteem,personal self-esteem,and subjective well-being.Path analysis findings result indicated national identity to influence the students’subjective wellbeing through three pathways:(1)national identity→collective self-esteem→subjective well-being,meaning higher subjective wellbeing with collective self-esteem.(2)national identity→personal self-esteem→subjective well-being,to suggest higher personal self-esteem was associated with subjective wellbeing;(3)national identity→collective selfesteem→personal self-esteem→subjective well-being.Compared to simple mediation models constructed with only personal self-esteem or collective self-esteem as a single mediating variable,the chain mediation model better explains the mediating mechanism of national identity on subjective well-being(the variance explained by the mediating variables increased by 65.38%and 59.26%,respectively).The collective self-esteem and personal self-esteem mediation is consistent with social identity theory,whereby national identity enhances collective self-evaluation,which in turn bolsters personal self-worth and subjective well-being.These findings of the current study offer new insights into how national identity affects subjective well-being in collectivistic culture. 展开更多
关键词 National identity collective self-esteem personal self-esteem mediating effect
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Smarter,Not More:The Rationale for Reducing Systematic Cores in theMRI-Targeted Biopsy Era
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作者 Zhihong Lv Yong Xu Xingkang Jiang 《The Canadian Journal of Urology》 2026年第1期1-2,共2页
We read with great interest Deng et al.’s study 1 comparing sextant(6-core)and 12-core systematic biopsy in theMRI-targeted era,which valuably challenges the“more cores=higher accuracy”dogma by proposing a precisio... We read with great interest Deng et al.’s study 1 comparing sextant(6-core)and 12-core systematic biopsy in theMRI-targeted era,which valuably challenges the“more cores=higher accuracy”dogma by proposing a precision sampling strategy based on prostate cancer’s spatial distribution,aligning with personalized diagnosis trends. 展开更多
关键词 personalized diagnosis trends not CORES MORE MRI targeted BIOPSY systematic precision sampling strategy
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The Impact of Personalized Nutritional Support on Complications and Pregnancy Outcomes in Advanced Maternal Age Women with Gestational Diabetes Mellitus
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作者 Jiaqi Xiong 《Journal of Clinical and Nursing Research》 2026年第1期48-55,共8页
Objective:To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes(GDM),and explore its impact on the incidence of maternal complications and pregnancy outcomes.Met... Objective:To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes(GDM),and explore its impact on the incidence of maternal complications and pregnancy outcomes.Methods:A total of 90 elderly pregnant women with gestational diabetes who were delivered in our hospital from January 2023 to January 2024 were selected as the research objects.They were randomly divided into an observation group and a control group,with 45 cases in each group.The control group only received routine pregnancy care and basic nutrition guidance,while the observation group received personalized nutrition support on this basis.Compare the blood glucose control,incidence of pregnancy complications,pregnancy outcomes,and neonatal outcomes between two groups of parturient.Result:After intervention,the fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)of the observation group were significantly lower than those of the control group,and the differences were statistically significant(p<0.05);The incidence of complications such as gestational hypertension syndrome,polyhydramnios,premature rupture of membranes,and postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the difference was statistically significant(p<0.05);The cesarean section rate in the observation group was significantly lower than that in the control group,and the incidence of adverse neonatal outcomes such as fetal distress,macrosomia,neonatal asphyxia,and neonatal hypoglycemia in the observation group was significantly lower than that in the control group,with statistical significance(p<0.05).Conclusion:Individualized nutritional support for elderly women with gestational diabetes can effectively improve the level of maternal blood sugar control,reduce the incidence of complications during pregnancy,and improve the outcome of pregnancy and neonatal outcomes,which is of high clinical value. 展开更多
关键词 personalized nutritional support Elderly parturient Gestational diabetes COMPLICATION Pregnancy outcome Newborn outcome
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Dual Channel Graph Convolutional Networks via Personalized PageRank
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作者 Longlong Lin Xin Luo 《IEEE/CAA Journal of Automatica Sinica》 2026年第1期221-223,共3页
Dear Editor,D2This letter presents a node feature similarity preserving graph convolutional framework P G.Graph neural networks(GNNs)have garnered significant attention for their efficacy in learning graph representat... Dear Editor,D2This letter presents a node feature similarity preserving graph convolutional framework P G.Graph neural networks(GNNs)have garnered significant attention for their efficacy in learning graph representations across diverse real-world applications. 展开更多
关键词 convolutional node feature similarity graph convolutional framework learning graph representations neural networks gnns NETWORKS GRAPH personalIZED
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Personalized Differential Privacy for Support Vector Machines
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作者 WANG Xiaofeng LIU Xingwei XU Wangli 《Journal of Systems Science & Complexity》 2026年第1期180-202,共23页
The support vector machine,a widely used binary classification method,may expose sensitive information during training.To address this,the authors propose a personalized differential privacy method that extends differ... The support vector machine,a widely used binary classification method,may expose sensitive information during training.To address this,the authors propose a personalized differential privacy method that extends differential privacy.Specifically,the authors introduce personalized differentially private support vector machines to meet different individuals'privacy requirements,using a reweighting strategy and the Laplace mechanism.Theoretical analysis demonstrates that the proposed methods simultaneously satisfy the requirements of personalized differential privacy and ensure model prediction accuracy at these privacy levels.Extensive experiments demonstrate that the proposed methods outperform the existing methods. 展开更多
关键词 Laplace mechanism personalized differential privacy reweighting strategy support vector machine
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Discontinuation of advanced therapy in inflammatory bowel disease:Updated evidence,guidelines,and personalized decision-making one year later
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作者 Salvatore Greco Michele Campigotto NicolòFabbri 《World Journal of Clinical Cases》 2026年第1期52-56,共5页
Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the... Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the publication by Meštrovićet al,emphasizing the complex balance between risks of relapse,antidrug antibody formation,and potential complications of long-term immunosuppression.Recent evidence underscores high relapse rates following withdrawal-especially of anti-tumor necrosis factor agents-and highlights the lack of robust data for newer biologics.Updated guidelines from European Crohn’s and Colitis Organization,British Society of Gastroenterology,and American College of Gastroenterology all support cautious and individualized approaches,with strict criteria and close follow-up,particularly in Crohn’s disease.For ulcerative colitis,therapeutic cycling remains insufficiently addressed.We proposed a flowchart to support clinical decision-making and stress the importance of shared decisionmaking in the era of personalized medicine since,despite new drug classes and evolving strategies,the therapeutic ceiling in inflammatory bowel disease has yet to be fully overcome. 展开更多
关键词 Crohn’s disease Ulcerative colitis Inflammatory bowel disease Biologic therapy Discontinuation of therapy personalized medicine
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Personalized Differential Privacy Graph Neural Network
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作者 Yanli Yuan Dian Lei +3 位作者 Chuan Zhang Zehui Xiong Chunhai Li Liehuang Zhu 《IEEE/CAA Journal of Automatica Sinica》 2026年第2期498-500,共3页
Dear Editor,This letter addresses the critical challenge of preserving privacy in graph learning without compromising on data utility.Differential privacy(DP)is emerging as an effective method for privacy-preserving g... Dear Editor,This letter addresses the critical challenge of preserving privacy in graph learning without compromising on data utility.Differential privacy(DP)is emerging as an effective method for privacy-preserving graph learning.However,its application often diminishes data utility,especially for nodes with fewer neighbors in graph neural networks(GNNs). 展开更多
关键词 graph neural networks gnns personalized differential privacy graph learning privacy preservation data utility preserving privacy graph neural network
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Novel Statistical Shape Relation and Prediction of Personalized Female Pelvis,Pelvic Floor,and Perineal Muscle Shapes
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作者 Tan-Nhu Nguyen Trong-Pham Nguyen-Huu Tien-Tuan Dao 《Computer Modeling in Engineering & Sciences》 2026年第2期1-47,共47页
Vaginal delivery is a fascinating physiological process,but also a high-risk process.Up to 85%–90%of vaginal deliveries lead to perineal trauma,with nearly 11%of severe perineal tearing.It is a common occurrence,espe... Vaginal delivery is a fascinating physiological process,but also a high-risk process.Up to 85%–90%of vaginal deliveries lead to perineal trauma,with nearly 11%of severe perineal tearing.It is a common occurrence,especially for first-time mothers.Computational childbirth plays an essential role in the prediction and prevention of these traumas,but fast personalization of the pelvis and floor muscles is challenging due to their anatomical complexity.This study introduces a novel shape-prediction-based personalization of the pelvis and floor muscles for perineal tearing management and childbirth simulation.300 subjects were selected from public Computed Tomography(CT)databases.The pelvic bone nmjmeshes were generated using a coarse-to-fine non-rigid mesh alignment procedure.The floor muscle meshes were personalized using the bone mesh deformation information.A feature-to-pelvic structure reconstruction pipeline was proposed,incorporating various strategies.Ten-fold cross-validation helped determine the optimal reconstruction strategy,regression method,and feature sizes.The mesh-to-mesh distance metric was employed for evaluating.The statistical shape relation-based strategy,coupled with multi-output ridge regression,was the optimal approach for pelvic structure reconstruction.With a feature set ranging from 3 to 38,the mean errors were 2.672 to 1.613 mm,and 3.237 to 1.415 mm in muscle attachment regions.The best-and worst-case predictions had errors of 1.227±0.959 mm and 2.900±2.309 mm,respectively.This study provides a novel approach to achieving fast personalized childbirth modeling and simulation for perineal tearing management. 展开更多
关键词 personalized statistical shape relation shape prediction female pelvis shape pelvic floor and perineal tissue shape
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The personal protective equipment(PPE)based on individual combat:A systematic review and trend analysis 被引量:4
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作者 Qian-ran Hu Xing-yu Shen +2 位作者 Xin-ming Qian Guang-yan Huang Meng-qi Yuan 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第10期195-221,共27页
With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce ... With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce casualties and maintain military combat effectiveness,is widely developed.This paper systematically reviewed various PPE based on individual combat through literature research and comprehensive discussion,and introduced in detail the latest application progress of PPE in terms of material and technology from three aspects:individual integrated protection system,traditional protection equipment,and intelligent protection equipment,respectively,and discussed in depth the functional improvement and optimization status brought by advanced technology for PPE,focusing on the achievements of individual equipment technology application.Finally,the problems and technical bottlenecks in the development of PPE were analyzed and summarized,and the development trend of PPE were pointed out.The results of the review will provide a forward-looking reference for the current development of individual PPE,and are important guidance for the design and technological innovation of advanced equipment based on the future technological battlefield. 展开更多
关键词 personal protective equipment(PPE) Individual combat Material and structure Equipment application Intelligent devices Wearable technology
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A Review on Effects of Personalized Ventilation Systems on Air Quality and Thermal Comfort in Aircraft Cabin Mini-Environments 被引量:4
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作者 SUN Jianhong CHANFIOU Ahmed Mboreha +1 位作者 WANG Yan SUN Zhi 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2022年第2期121-142,共22页
This study conducts an evaluation of air quality,dispersion of airborne expiratory pollutants and thermal comfort in aircraft cabin mini-environments using a critical examination of significant studies conducted over ... This study conducts an evaluation of air quality,dispersion of airborne expiratory pollutants and thermal comfort in aircraft cabin mini-environments using a critical examination of significant studies conducted over the last20 years.The research methods employed in these studies are also explained in detail.Based on the current literature,standard procedures for airplane personal ventilation and air quality investigations are defined for each study approach.Present study gaps are examined,and prospective study subjects for various research approaches are suggested. 展开更多
关键词 personal ventilation system computational fluid dynamics(CFD) mini-environment AIRCRAFT thermal comfort
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Web-based GIS System for Real-time Field Data Collection Using Personal Mobile Phone 被引量:2
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作者 Ko Ko Lwin Yuji Murayama 《Journal of Geographic Information System》 2011年第4期382-389,共8页
Recently, use of mobile communicational devices in field data collection is increasing such as smart phones and cellular phones due to emergence of embedded Global Position System GPS and Wi-Fi Internet access. Accura... Recently, use of mobile communicational devices in field data collection is increasing such as smart phones and cellular phones due to emergence of embedded Global Position System GPS and Wi-Fi Internet access. Accurate timely and handy field data collection is required for disaster management and emergency quick responses. In this article, we introduce web-based GIS system to collect the field data by personal mobile phone through Post Office Protocol POP3 mail server. The main objective of this work is to demonstrate real-time field data collection method to the students using their mobile phone to collect field data by timely and handy manners, either individual or group survey in local or global scale research. 展开更多
关键词 WEB-BASED GIS system REAL-TIME Field Data Collection personal Mobile PHONE POP3 MAIL Server
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A Personalized Search Model Using Online Social Network Data Based on a Holonic Multiagent System 被引量:2
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作者 Meijia Wang Qingshan Li Yishuai Lin 《China Communications》 SCIE CSCD 2020年第2期176-205,共30页
Personalized search utilizes user preferences to optimize search results,and most existing studies obtain user preferences by analyzing user behaviors in search engines that provide click-through data.However,the beha... Personalized search utilizes user preferences to optimize search results,and most existing studies obtain user preferences by analyzing user behaviors in search engines that provide click-through data.However,the behavioral data are noisy because users often clicked some irrelevant documents to find their required information,and the new user cold start issue represents a serious problem,greatly reducing the performance of personalized search.This paper attempts to utilize online social network data to obtain user preferences that can be used to personalize search results,mine the knowledge of user interests,user influence and user relationships from online social networks,and use this knowledge to optimize the results returned by search engines.The proposed model is based on a holonic multiagent system that improves the adaptability and scalability of the model.The experimental results show that utilizing online social network data to implement personalized search is feasible and that online social network data are significant for personalized search. 展开更多
关键词 personalized search online social network holonic multiagent system
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Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer 被引量:1
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作者 Anna Maria Berghella Anna Aureli +3 位作者 Angelica Canossi Tiziana Del Beato Alessia Colanardi Patrizia Pellegrini 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2019年第2期117-138,共22页
BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predicti... BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxidation and immune products are a biomarker system for aging and cancer. 展开更多
关键词 AGING and CANCER BIOMARKER CANCER personalized treatments Oxidation and IMMUNE biomarkers Trx1/CD30 target KIRs and FCΓR polymorphisms Th cytokines AGING and disease Cancer-related mechanisms
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Personalized cardiovascular intervention simulation system 被引量:4
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作者 Aimin HAO Jiahao CUI +1 位作者 Shuai LI Qinping ZHAO 《Virtual Reality & Intelligent Hardware》 2020年第2期104-118,共15页
Background This study proposes a series of geometry and physics modeling methods for personalized cardiovascular intervention procedures,which can be applied to a virtual endovascular simulator.Methods Based on person... Background This study proposes a series of geometry and physics modeling methods for personalized cardiovascular intervention procedures,which can be applied to a virtual endovascular simulator.Methods Based on personalized clinical computed tomography angiography(CTA)data,mesh models of the cardiovascular system were constructed semi-automatically.By coupling 4 D magnetic resonance imaging(MRI)sequences corresponding to a complete cardiac cycle with related physics models,a hybrid kinetic model of the cardiovascular system was built to drive kinematics and dynamics simulation.On that basis,the surgical procedures related to intervention instruments were simulated using specially-designed physics models.These models can be solved in real-time;therefore,the complex interactions between blood vessels and instruments can be well simulated.Additionally,X-ray imaging simulation algorithms and realistic rendering algorithms for virtual intervention scenes are also proposed.In particular,instrument tracking hardware with haptic feedback was developed to serve as the interaction interface of real instruments and the virtual intervention system.Finally,a personalized cardiovascular intervention simulation system was developed by integrating the techniques mentioned above.Results This system supported instant modeling and simulation of personalized clinical data and significantly improved the visual and haptic immersions of vascular intervention simulation.Conclusions It can be used in teaching basic cardiology and effectively satisfying the demands of intervention training,personalized intervention planning,and rehearsing. 展开更多
关键词 personalized cardiovascular modeling Intervention simulation system Intervention instrument simulation X-ray imaging simulation Hybrid model
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Securing Patient-Centric Personal Health Records Sharing System in Cloud Computing
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作者 CHEN Danwei CHEN Linling +3 位作者 FAN Xiaowei HE Liwen PAN Su Hu Ruoxiang 《China Communications》 SCIE CSCD 2014年第A01期121-127,共7页
Personal health record (PHR) enables patients to manage their own electronic medical records (EMR) in a centralized way, and it is oRen outsourced to be stored in a third-party server. In this paper we propose a n... Personal health record (PHR) enables patients to manage their own electronic medical records (EMR) in a centralized way, and it is oRen outsourced to be stored in a third-party server. In this paper we propose a novel secure and scalable system for sharing PHRs. We focus on the multiple data owner scenario, and divide the users in the system into multiple security domains that greatly reduce the key management complexity for owners and users. A high degree of patient privacy is guaranteed by exploiting hierarchical and multi- authority attribute-sets based encryption (HM- ASBE). Our system not only supports compound attributes due to flexible attribute sets combinations, but also achieves fine-grained access control. Our scheme supports efficient on-demand user/attribute revocation and break-glass access under emergency scenarios. 展开更多
关键词 personal health records attribute- based encryption data privacy fine-grained access control
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