Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topologi...Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topological Characteristics (PPTC) and Spectral Matching (SM) together to solve the afore mentioned issues. In which PPTC, a new shape descriptor, is firstly proposed. A new comparability measurement based on PPTC is defined as the matching probability. Finally, the correct matching results are achieved by the spectral matching method. The synthetic data experiments show its robustness by comparing with the other state-of-art algorithms and the real world data experiments show its effectiveness.展开更多
The mutation pattern in protein is a very important feature and is studied through various approaches including the study on mutation pattern in domains where amino acids are converted into numbers from letters. In th...The mutation pattern in protein is a very important feature and is studied through various approaches including the study on mutation pattern in domains where amino acids are converted into numbers from letters. In this study, we converted the amino acids in human adrenoleukodystrophy protein with its 128 missense mutations into random domain using the amino-acid pair predictability, and then we studied their mutation patterns. The results show 1) the mutations are more likely to target the amino-acid pairs whose actual frequency is larger than their predicted one, 2) the mutations are more likely to form the amino-acid pairs whose actual frequency is smaller than their predicted frequency, 3) mutations are more likely to occur at unpredictable amino-acid pairs, and 4) mutations have the trend to narrow the difference between predicted and actual frequencies of amino-acid pairs.展开更多
The use of leading edge with different geometrical patterns will affect the development of boundary layer flow on a flat plate and its heat transfer properties. In this work, the effects of three patterns namely saw-t...The use of leading edge with different geometrical patterns will affect the development of boundary layer flow on a flat plate and its heat transfer properties. In this work, the effects of three patterns namely saw-tooth, semicircular and slots with same wavelength and amplitude were examined. The experiments were carried out for Reynolds number based on wavelength of patterns ranging from 1540 to 3850. For all cases, after each valley, an oval shape region was formed containing a counter- rotating vortex pair. It is also shown that for the flat plate with slots, another vortex was visualized between each valley.展开更多
Lysostaphin is widely used in clinical settings against Staphylococcus aureus, but its mutants can abolish its killing activity. The difficulty in studies of mutations in lysostaphin is the shortage of data, which may...Lysostaphin is widely used in clinical settings against Staphylococcus aureus, but its mutants can abolish its killing activity. The difficulty in studies of mutations in lysostaphin is the shortage of data, which may need many decades to collect, although lysostaphin is so important for clinical therapeutics and drug development. In order not to passively wait for the accumulation of new data, in this study 1) the 23,442 mutations in 1408 proteins from databank were used to determine whether the mutations in lysostaphin follow the general mutation trend obtained from the databank, 2) the amino-acid pair predictability was used to explore the underlined mechanism for lysostaphin mutations, and 3) the amino-acid distribution probability was used to associate the mutation with dysfunction of lysostaphin. The results show that the mutations in lysostaphin follow the general trend of mutations in proteins;the underlined mechanism for mutations in lysostaphin is explainable from a viewpoint of randomness, and a mutation with increased distribution probability would have a larger chance to dysfunction lysostaphin. This study provides useful information for future design of anti-S. aureus drug and enzyme engineering.展开更多
文摘Most of the Point Pattern Matching (PPM) algorithm performs poorly when the noise of the point's position and outliers exist. This paper presents a novel and robust PPM algorithm which combined Point Pair Topological Characteristics (PPTC) and Spectral Matching (SM) together to solve the afore mentioned issues. In which PPTC, a new shape descriptor, is firstly proposed. A new comparability measurement based on PPTC is defined as the matching probability. Finally, the correct matching results are achieved by the spectral matching method. The synthetic data experiments show its robustness by comparing with the other state-of-art algorithms and the real world data experiments show its effectiveness.
文摘The mutation pattern in protein is a very important feature and is studied through various approaches including the study on mutation pattern in domains where amino acids are converted into numbers from letters. In this study, we converted the amino acids in human adrenoleukodystrophy protein with its 128 missense mutations into random domain using the amino-acid pair predictability, and then we studied their mutation patterns. The results show 1) the mutations are more likely to target the amino-acid pairs whose actual frequency is larger than their predicted one, 2) the mutations are more likely to form the amino-acid pairs whose actual frequency is smaller than their predicted frequency, 3) mutations are more likely to occur at unpredictable amino-acid pairs, and 4) mutations have the trend to narrow the difference between predicted and actual frequencies of amino-acid pairs.
文摘The use of leading edge with different geometrical patterns will affect the development of boundary layer flow on a flat plate and its heat transfer properties. In this work, the effects of three patterns namely saw-tooth, semicircular and slots with same wavelength and amplitude were examined. The experiments were carried out for Reynolds number based on wavelength of patterns ranging from 1540 to 3850. For all cases, after each valley, an oval shape region was formed containing a counter- rotating vortex pair. It is also shown that for the flat plate with slots, another vortex was visualized between each valley.
文摘Lysostaphin is widely used in clinical settings against Staphylococcus aureus, but its mutants can abolish its killing activity. The difficulty in studies of mutations in lysostaphin is the shortage of data, which may need many decades to collect, although lysostaphin is so important for clinical therapeutics and drug development. In order not to passively wait for the accumulation of new data, in this study 1) the 23,442 mutations in 1408 proteins from databank were used to determine whether the mutations in lysostaphin follow the general mutation trend obtained from the databank, 2) the amino-acid pair predictability was used to explore the underlined mechanism for lysostaphin mutations, and 3) the amino-acid distribution probability was used to associate the mutation with dysfunction of lysostaphin. The results show that the mutations in lysostaphin follow the general trend of mutations in proteins;the underlined mechanism for mutations in lysostaphin is explainable from a viewpoint of randomness, and a mutation with increased distribution probability would have a larger chance to dysfunction lysostaphin. This study provides useful information for future design of anti-S. aureus drug and enzyme engineering.
