The introduction of laparoscopy in the surgeon’s armamentarium was in fact a “revolution in the history of surgery”. Since this technique involves insufflation of carbon dioxide it ...The introduction of laparoscopy in the surgeon’s armamentarium was in fact a “revolution in the history of surgery”. Since this technique involves insufflation of carbon dioxide it produces several pathophysiological changes which have to be understood by the anaesthesiologist who can modify the anaesthesia technique accordingly. Advantages of laparoscopy include reduced pain, small scars and early return to work. Certain complications specific to laparoscopic surgery are due to carboperitoneum and increased intra-abdominal pressure. Venous air embolism, although very rare, can be lethal if not managed promptly. Other complications include subcutaneous emphysema, haemodynamic compromise and arrhythmias. Although associated with minimal postoperative morbidity, postoperative pain, nausea and vomiting can be quite problematic. The limitations of laparoscopy have been overcome by the introduction of robotic surgery. There are important implications for the anaesthesiologist during robotic surgeries which have to be practiced accordingly. Robotic surgery has a learning curve for both the surgeon and the anaesthesiologist. The robot is bulky, and cannot be disengaged after docking. Therefore it is important that the anaesthetized patient remains immobile throughout surgery and anaesthesia is reversed only after the robot has been disengaged at the end of surgery. Advances in laparoscopy and robotic surgery have modified anaesthetic techniques too.展开更多
Stroke is one of the leading causes of death and long-term disability worldwide,severely affecting patients'quality of life and socio-economic development.In recent years,with advancements in neuroscience,research...Stroke is one of the leading causes of death and long-term disability worldwide,severely affecting patients'quality of life and socio-economic development.In recent years,with advancements in neuroscience,researchers have gradually recognized that neuroinflammation plays critical roles in the neurorestoration after stroke.1 Understanding the molecular mechanisms of these processes helps reveal the complex pathophysiological changes following stroke and provides new perspectives for developing effective therapeutic strategies.2 This editorial aims to explore the molecular mechanisms of neuroinflammation and neurorestoration after stroke and review current therapeutic strategies to provide theoretical support for clinical interventions.展开更多
文摘The introduction of laparoscopy in the surgeon’s armamentarium was in fact a “revolution in the history of surgery”. Since this technique involves insufflation of carbon dioxide it produces several pathophysiological changes which have to be understood by the anaesthesiologist who can modify the anaesthesia technique accordingly. Advantages of laparoscopy include reduced pain, small scars and early return to work. Certain complications specific to laparoscopic surgery are due to carboperitoneum and increased intra-abdominal pressure. Venous air embolism, although very rare, can be lethal if not managed promptly. Other complications include subcutaneous emphysema, haemodynamic compromise and arrhythmias. Although associated with minimal postoperative morbidity, postoperative pain, nausea and vomiting can be quite problematic. The limitations of laparoscopy have been overcome by the introduction of robotic surgery. There are important implications for the anaesthesiologist during robotic surgeries which have to be practiced accordingly. Robotic surgery has a learning curve for both the surgeon and the anaesthesiologist. The robot is bulky, and cannot be disengaged after docking. Therefore it is important that the anaesthetized patient remains immobile throughout surgery and anaesthesia is reversed only after the robot has been disengaged at the end of surgery. Advances in laparoscopy and robotic surgery have modified anaesthetic techniques too.
基金supported by grants from the National Natural Science Foundation of China(81960234,82071331)National Key Research and Development Program of China(2018YFC1312200)+3 种基金Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20232401)Henan Province Medical Science and Technology Research Program(SBGJ202403031)Hunan Provincial Natural Science Foundation(2023JJ40572)Canadian Institutes of Health Research(VWY)。
文摘Stroke is one of the leading causes of death and long-term disability worldwide,severely affecting patients'quality of life and socio-economic development.In recent years,with advancements in neuroscience,researchers have gradually recognized that neuroinflammation plays critical roles in the neurorestoration after stroke.1 Understanding the molecular mechanisms of these processes helps reveal the complex pathophysiological changes following stroke and provides new perspectives for developing effective therapeutic strategies.2 This editorial aims to explore the molecular mechanisms of neuroinflammation and neurorestoration after stroke and review current therapeutic strategies to provide theoretical support for clinical interventions.
