Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Me...Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. Study selection These reports from major review on coronary artery spasm .and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Results Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Conclusion Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.展开更多
Pathogen-driven crop losses pose a significant threat to global food security.Plants deploy two primary branches of innate immunity:pathogen-associated molecular pattern-triggered immunity(PTI)and effector-triggered i...Pathogen-driven crop losses pose a significant threat to global food security.Plants deploy two primary branches of innate immunity:pathogen-associated molecular pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)(Yu et al.,2024).While PTI relies on surface-localized pattern recognition receptors,ETI is mediated by intracellular nucleotide-binding leucine-rich repeat receptors(NLRs)that directly or indirectly recognize pathogen effectors,often triggering hypersensitive cell death and systemic resistance(Yu et al.,2024).展开更多
文摘Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. Study selection These reports from major review on coronary artery spasm .and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Results Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Conclusion Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.
基金supported by the Beijing Life Science Academy(Key Laboratory)Project(2024400CB0120)the National Key Research and Development Program of China(2021YFD1400400 and 2022YFD1400800)the National Natural Science Foundation of China(32130086,32430085,and 32300123).
文摘Pathogen-driven crop losses pose a significant threat to global food security.Plants deploy two primary branches of innate immunity:pathogen-associated molecular pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)(Yu et al.,2024).While PTI relies on surface-localized pattern recognition receptors,ETI is mediated by intracellular nucleotide-binding leucine-rich repeat receptors(NLRs)that directly or indirectly recognize pathogen effectors,often triggering hypersensitive cell death and systemic resistance(Yu et al.,2024).
