Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptio...Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptions due to its subtropical monsoon climate,including typhoons and gusty winds,present ongoing challenges.Despite the growing focus on operational costs and third-party risks,research on low-altitude urban wind fields remains scarce.This study addresses this gap by integrating wind field analysis into UAV path planning,introducing key innovations to the classical model.First,UAV wind resistance and turbulence constraints are analyzed,mapping high-wind-speed and turbulence-prone zones in the airspace.Second,wind dynamics are incorporated into path planning by considering airspeed and groundspeed variation,optimizing waypoint selection and flight speed adjustments to improve overall energy efficiency.Additionally,a wind-aware Theta*algorithm is proposed,leveraging wind vectors to expedite search process,while Computational Fluid Dynamics(CFD)techniques are employed to calculate wind fields.A case study of Shenzhen,examining wind patterns over the past decade,demonstrates a 6.23%improvement in groundspeed and a 7.69%reduction in energy consumption compared to wind-agnostic models.This framework advances UAV logistics by enhancing route safety and energy efficiency,contributing to more cost-effective operations.展开更多
Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i...Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.展开更多
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes...Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.展开更多
BACKGROUND Diabetic encephalopathy(DE)is a common and serious complication of diabetes that can cause death in many patients and significantly affects the lives of individuals and society.Multiple studies investigatin...BACKGROUND Diabetic encephalopathy(DE)is a common and serious complication of diabetes that can cause death in many patients and significantly affects the lives of individuals and society.Multiple studies investigating the pathogenesis of DE have been reported.However,few studies have focused on scientometric analysis of DE.AIM To analyze literature on DE using scientometrics to provide a comprehensive picture of research directions and progress in this field.METHODS We reviewed studies on DE or cognitive impairment published between 2004 and 2023.The latter were used to identify the most frequent keywords in the keyword analysis and explore the hotspots and trends of DE.RESULTS Scientometric analysis revealed 1308 research papers on DE,a number that increased annually over the past 20 years,and that the primary topics explored were domain distribution,knowledge structure,evolution,and emergence of research topics related to DE.The inducing factors,comorbidities,pathogenesis,treatment,and animal models of DE help clarify its occurrence,development,and treatment.An increasing number of studies on DE may be a result of the recent increase in patients with diabetes,unhealthy lifestyles,and unhealthy eating habits,which have aggravated the incidence of this disease.CONCLUSION We identified the main inducing factors and comorbidities of DE,though other complex factors undoubtedly increase social and economic burdens.These findings provide vital references for future studies.展开更多
BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features ...BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.展开更多
With the advent of the digital-intelligence economy era,intelligence and networking have profoundly changed people’s lifestyles and working methods,and also posed new challenges and requirements for enterprise manage...With the advent of the digital-intelligence economy era,intelligence and networking have profoundly changed people’s lifestyles and working methods,and also posed new challenges and requirements for enterprise management.Against this background,modern management has become a new trend in the transformation of enterprise management.Based on this,this paper conducts research on the modernization transformation path of enterprise management in the digital-intelligence economy era,expounds the impact of the digital-intelligence economy on enterprise management in China,analyzes the connotation of modernization of enterprise management,and proposes the modernization transformation path of enterprise management,aiming to provide theoretical reference and practical guidance for enterprises to achieve modern management in the wave of the digital-intelligence economy.展开更多
Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of mult...Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of multi-sensor fusion localization algorithms for smart plastering robots,and an analysis of path planning and navigation functions for smart plastering robots.It is hoped that through this analysis,a reference is provided for the path planning and navigation design of such robots to meet their practical application needs.展开更多
Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT^(*)),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narr...Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT^(*)),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narrow passages,slow convergence,and high computational costs.To address these challenges,this paper proposes a novel hybrid global path planning algorithm integrating Gaussian sampling and quadtree optimization(RRT^(*)-GSQ).This methodology aims to enhance path planning by synergistically combining a Gaussian mixture sampling strategy to improve node generation in critical regions,an adaptive step-size and direction optimization mechanism for enhanced obstacle avoidance,a Quadtree-AABB collision detection framework to lower computational complexity,and a dynamic iteration control strategy for more efficient convergence.In obstacle-free and obstructed scenarios,compared with the conventional RRT^(*),the proposed algorithm reduced the number of node evaluations by 67.57%and 62.72%,and decreased the search time by 79.72%and 78.52%,respectively.In path tracking tests,the proposed algorithm achieved substantial reductions in RMSE of the final path compared to the conventional RRT^(*).Specifically,the lateral RMSE was reduced by 41.5%in obstacle-free environments and 59.3%in obstructed environments,while the longitudinal RMSE was reduced by 57.2%and 58.5%,respectively.Furthermore,the maximum absolute errors in both lateral and longitudinal directions were constrained within 0.75 m.Field validation experiments in an operational orchard confirmed the algorithm's practical effectiveness,showing reductions in the mean tracking error of 47.6%(obstacle-free)and 58.3%(with obstructed),alongside a 5.1%and 7.2%shortening of the path length compared to the baseline method.The proposed algorithm effectively enhances path planning efficiency and navigation accuracy for robots,presenting a superior solution for high-precision autonomous navigation of agricultural robots in orchard environments and holding significant value for engineering applications.展开更多
Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on...Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on patients and healthcare systems.To the best of our knowledge,research hotspots within the field of DPN are yet to be visually analyzed,and so is the exploration of developmental dynamics within the same discipline.Methods:Herein,DPN articles published between 2002 and 2022 were retrieved from the Web of Science Core Collection database.Following that,bibliometric analysis was performed on these articles using CiteSpace,VOSviewer,Microsoft Excel,and R-bibliometrix tools.Results:We retrieved 2,761 DPN articles involving 11,605 researchers from 1,140 institutions in 99 countries/regions.The United States was the country/region with the highest number of publications.The most productive author was Malik Rayaz A from the University of Manchester,which was the most productive institution.The most co-cited journals were Diabetes Care,Pain,and Neurology.On the other hand,#0 neuropathic pain,#1 neuropathic pain treatment and#2 peripheral neuropathy were the most clustered keywords in co-cited references.Based on the clustering of keywords,timeline graphs,and citation bursts,“risk”,“corneal confocal microscopy”and“systematic review”were identifi ed as the key issues for future DPN research.Conclusion:This article summarizes the current DPN research status and focus areas,reveals the future development trend,and points out potential research directions for DPN scholars.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM ...BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.展开更多
As an integral part of China’s higher education system,higher vocational colleges play a significant role in talent cultivation,social services,and cultural inheritance.With the development of the times and the advan...As an integral part of China’s higher education system,higher vocational colleges play a significant role in talent cultivation,social services,and cultural inheritance.With the development of the times and the advancement of educational reform,the role of scientific research in higher vocational colleges has become increasingly prominent.This paper started from the necessity of conducting scientific research in higher vocational colleges,providing an in-depth analysis of its importance in improving teaching quality,promoting teachers’professional development,driving social services,and enhancing the college’s core competitiveness.At the same time,addressing the existing problems in current scientific research work at higher vocational colleges,this paper proposed innovative pathways focusing on the scientific research management system,scientific research team construction,scientific research funding investment,and scientific research outcome transformation.The aim is to provide valuable references for the scientific research development of higher vocational colleges.展开更多
Discussions on Chinese modernization are offering African countries both conceptual inspiration and practical references as they explore their own sustainable development paths.
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'...Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.展开更多
Objective:To identify promising biomarkers for the pathogenesis of major depressive disorder(MDD).Methods:Microarray chips of MDD patients,including the GSE98793,GSE52790,and GSE39653 datasets,were obtained from the G...Objective:To identify promising biomarkers for the pathogenesis of major depressive disorder(MDD).Methods:Microarray chips of MDD patients,including the GSE98793,GSE52790,and GSE39653 datasets,were obtained from the Gene Expression Omnibus database.The biological processes and pathways related to MDD were investigated using the GO and KEGG pathway tools.Weighted gene coexpression network analysis was conducted to identify modules related to MDD.The hub genes associated with MDD were obtained via protein-protein interaction analysis.Finally,the expression of hub genes in the hippocampal tissues of depression-like rats was detected by reverse transcription-polymerase chain reaction and Western blotting.Results:A total of 658 differentially expressed genes were identified from the Gene Expression Omnibus datasets;thus,these genes and the GSE98793 dataset were used to conduct weighted gene coexpression network analysis.A total of 244 module-related genes were identified and these genes were highly correlated with MDD.These genes were involved in the Ras signaling pathway,regulation of the actin cytoskeleton,and axon guidance according to the KEGG analysis.Hub genes,including MAPK14,SOCS1,TLR2,PTK2B,and GRB2,were obtained via protein-protein interaction analysis.All these hub genes showed better diagnostic efficiency in the GSE52790,GSE39653,and GSE98793 datasets.In vivo experiments revealed that compared with those in control rats,SOCS1 and MAPK14 expression was significantly decreased;while GRB2,TLR2,and PTK2B expression was increased in the hippocampi of depression-like rats.Conclusions:Our study demonstrates that GRB2,TLR2,SOCS1,PTK2B,and MAPK14 are promising hub genes,and targeting these five genes may be an effective treatment strategy for MDD.展开更多
BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structu...BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.展开更多
Q-learning is a classical reinforcement learning method with broad applicability.It can respond effectively to environmental changes and provide flexible strategies,making it suitable for solving robot path-planning p...Q-learning is a classical reinforcement learning method with broad applicability.It can respond effectively to environmental changes and provide flexible strategies,making it suitable for solving robot path-planning problems.However,Q-learning faces challenges in search and update efficiency.To address these issues,we propose an improved Q-learning(IQL)algorithm.We use an enhanced Ant Colony Optimization(ACO)algorithmto optimizeQtable initialization.We also introduce the UCH mechanism to refine the reward function and overcome the exploration dilemma.The IQL algorithm is extensively tested in three grid environments of different scales.The results validate the accuracy of themethod and demonstrate superior path-planning performance compared to traditional approaches.The algorithm reduces the number of trials required for convergence,improves learning efficiency,and enables faster adaptation to environmental changes.It also enhances stability and accuracy by reducing the standard deviation of trials to zero.On grid maps of different sizes,IQL achieves higher expected returns.Compared with the original Q-learning algorithm,IQL improves performance by 12.95%,18.28%,and 7.98% on 10*10,20*20,and 30*30 maps,respectively.The proposed algorithm has promising applications in robotics,path planning,intelligent transportation,aerospace,and game development.展开更多
基金supported by the National Natural Science Foundation of China(No.U2433214)。
文摘Shenzhen,a major city in southern China,has experienced rapid advancements in Unmanned Aerial Vehicle(UAV)technology,resulting in extensive logistics networks with thousands of daily flights.However,frequent disruptions due to its subtropical monsoon climate,including typhoons and gusty winds,present ongoing challenges.Despite the growing focus on operational costs and third-party risks,research on low-altitude urban wind fields remains scarce.This study addresses this gap by integrating wind field analysis into UAV path planning,introducing key innovations to the classical model.First,UAV wind resistance and turbulence constraints are analyzed,mapping high-wind-speed and turbulence-prone zones in the airspace.Second,wind dynamics are incorporated into path planning by considering airspeed and groundspeed variation,optimizing waypoint selection and flight speed adjustments to improve overall energy efficiency.Additionally,a wind-aware Theta*algorithm is proposed,leveraging wind vectors to expedite search process,while Computational Fluid Dynamics(CFD)techniques are employed to calculate wind fields.A case study of Shenzhen,examining wind patterns over the past decade,demonstrates a 6.23%improvement in groundspeed and a 7.69%reduction in energy consumption compared to wind-agnostic models.This framework advances UAV logistics by enhancing route safety and energy efficiency,contributing to more cost-effective operations.
文摘Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.
基金supported by grants from the Natural Science Foundation of Tianjin(General Program),Nos.23JCYBJC01390(to RL),22JCYBJC00220(to XC),and 22JCYBJC00210(to QL).
文摘Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.
基金Supported by the Beijing Natural Sciences Foundation No.7242240Doctoral Startup Fund,No.2024BSZR052new teachers at the Beijing University of Chinese Medicine started the funding project,No.2022-JYB-XJSJJ-021.
文摘BACKGROUND Diabetic encephalopathy(DE)is a common and serious complication of diabetes that can cause death in many patients and significantly affects the lives of individuals and society.Multiple studies investigating the pathogenesis of DE have been reported.However,few studies have focused on scientometric analysis of DE.AIM To analyze literature on DE using scientometrics to provide a comprehensive picture of research directions and progress in this field.METHODS We reviewed studies on DE or cognitive impairment published between 2004 and 2023.The latter were used to identify the most frequent keywords in the keyword analysis and explore the hotspots and trends of DE.RESULTS Scientometric analysis revealed 1308 research papers on DE,a number that increased annually over the past 20 years,and that the primary topics explored were domain distribution,knowledge structure,evolution,and emergence of research topics related to DE.The inducing factors,comorbidities,pathogenesis,treatment,and animal models of DE help clarify its occurrence,development,and treatment.An increasing number of studies on DE may be a result of the recent increase in patients with diabetes,unhealthy lifestyles,and unhealthy eating habits,which have aggravated the incidence of this disease.CONCLUSION We identified the main inducing factors and comorbidities of DE,though other complex factors undoubtedly increase social and economic burdens.These findings provide vital references for future studies.
文摘BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
文摘With the advent of the digital-intelligence economy era,intelligence and networking have profoundly changed people’s lifestyles and working methods,and also posed new challenges and requirements for enterprise management.Against this background,modern management has become a new trend in the transformation of enterprise management.Based on this,this paper conducts research on the modernization transformation path of enterprise management in the digital-intelligence economy era,expounds the impact of the digital-intelligence economy on enterprise management in China,analyzes the connotation of modernization of enterprise management,and proposes the modernization transformation path of enterprise management,aiming to provide theoretical reference and practical guidance for enterprises to achieve modern management in the wave of the digital-intelligence economy.
基金Science and Technology Research Project of Chongqing Education Commission(Project No.:KJQN202401902)Chongqing Construction Science and Technology Plan Project(Project No.:Chinese Society For Urban Studies,2024:3-24)+1 种基金cientific Research Fund Project of Chongqing Institute of Engineering(Project No.:2022gcky01)College Student Innovation and Entrepreneurship Training Program Project of Chongqing Institute of Engineering(Project No.:CXCY2024018)。
文摘Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of multi-sensor fusion localization algorithms for smart plastering robots,and an analysis of path planning and navigation functions for smart plastering robots.It is hoped that through this analysis,a reference is provided for the path planning and navigation design of such robots to meet their practical application needs.
基金National Natural Science Foundation of China(32301712)Natural Science Foundation of Jiangsu Province(BK20230548,BK20250876)+2 种基金Project of Faculty of Agricultural Equipment of Jiangsu University(NGXB20240203)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD-2023-87)Open Funding Project of the Key Laboratory of Modern Agricultural Equipment and Technology(Jiangsu University),Ministry of Education(MAET202101)。
文摘Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT^(*)),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narrow passages,slow convergence,and high computational costs.To address these challenges,this paper proposes a novel hybrid global path planning algorithm integrating Gaussian sampling and quadtree optimization(RRT^(*)-GSQ).This methodology aims to enhance path planning by synergistically combining a Gaussian mixture sampling strategy to improve node generation in critical regions,an adaptive step-size and direction optimization mechanism for enhanced obstacle avoidance,a Quadtree-AABB collision detection framework to lower computational complexity,and a dynamic iteration control strategy for more efficient convergence.In obstacle-free and obstructed scenarios,compared with the conventional RRT^(*),the proposed algorithm reduced the number of node evaluations by 67.57%and 62.72%,and decreased the search time by 79.72%and 78.52%,respectively.In path tracking tests,the proposed algorithm achieved substantial reductions in RMSE of the final path compared to the conventional RRT^(*).Specifically,the lateral RMSE was reduced by 41.5%in obstacle-free environments and 59.3%in obstructed environments,while the longitudinal RMSE was reduced by 57.2%and 58.5%,respectively.Furthermore,the maximum absolute errors in both lateral and longitudinal directions were constrained within 0.75 m.Field validation experiments in an operational orchard confirmed the algorithm's practical effectiveness,showing reductions in the mean tracking error of 47.6%(obstacle-free)and 58.3%(with obstructed),alongside a 5.1%and 7.2%shortening of the path length compared to the baseline method.The proposed algorithm effectively enhances path planning efficiency and navigation accuracy for robots,presenting a superior solution for high-precision autonomous navigation of agricultural robots in orchard environments and holding significant value for engineering applications.
基金supported by the Anhui Provincial Key Research and Development PlanThis study was supported by National Key Research and Development Program of China(No.2023YFF0724803)Yunnan Province“Xingdian Talent Support Program”Yunling Scholar Special Project(No.XDYC-YLXZ-2022-0027)Scientific Research Fund Project of Yunnan Provincial Education Department(No.2025Y0634,No.2025Y0627).
文摘Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on patients and healthcare systems.To the best of our knowledge,research hotspots within the field of DPN are yet to be visually analyzed,and so is the exploration of developmental dynamics within the same discipline.Methods:Herein,DPN articles published between 2002 and 2022 were retrieved from the Web of Science Core Collection database.Following that,bibliometric analysis was performed on these articles using CiteSpace,VOSviewer,Microsoft Excel,and R-bibliometrix tools.Results:We retrieved 2,761 DPN articles involving 11,605 researchers from 1,140 institutions in 99 countries/regions.The United States was the country/region with the highest number of publications.The most productive author was Malik Rayaz A from the University of Manchester,which was the most productive institution.The most co-cited journals were Diabetes Care,Pain,and Neurology.On the other hand,#0 neuropathic pain,#1 neuropathic pain treatment and#2 peripheral neuropathy were the most clustered keywords in co-cited references.Based on the clustering of keywords,timeline graphs,and citation bursts,“risk”,“corneal confocal microscopy”and“systematic review”were identifi ed as the key issues for future DPN research.Conclusion:This article summarizes the current DPN research status and focus areas,reveals the future development trend,and points out potential research directions for DPN scholars.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金Supported by Grant-in-Aid for Research on Hepatitis from the Japan Agency for Medical Research and Development,No.24fk0210128h0002Grant-in-Aid for Scientific Research,No.KAKENHI-23K07372.
文摘BACKGROUND Congestive hepatopathy,also known as nutmeg liver,is liver damage secondary to chronic heart failure(HF).Its morphological characteristics in terms of medical imaging are not defined and remain unclear.AIM To leverage machine learning to capture imaging features of congestive hepatopathy using incidentally acquired computed tomography(CT)scans.METHODS We retrospectively analyzed 179 chronic HF patients who underwent echocardiography and CT within one year.Right HF severity was classified into three grades.Liver CT images at the paraumbilical vein level were used to develop a ResNet-based machine learning model to predict tricuspid regurgitation(TR)severity.Model accuracy was compared with that of six gastroenterology and four radiology experts.RESULTS In the included patients,120 were male(mean age:73.1±14.4 years).The accuracy of the results predicting TR severity from a single CT image for the machine learning model was significantly higher than the average accuracy of the experts.The model was found to be exceptionally reliable for predicting severe TR.CONCLUSION Deep learning models,particularly those using ResNet architectures,can help identify morphological changes associated with TR severity,aiding in early liver dysfunction detection in patients with HF,thereby improving outcomes.
文摘As an integral part of China’s higher education system,higher vocational colleges play a significant role in talent cultivation,social services,and cultural inheritance.With the development of the times and the advancement of educational reform,the role of scientific research in higher vocational colleges has become increasingly prominent.This paper started from the necessity of conducting scientific research in higher vocational colleges,providing an in-depth analysis of its importance in improving teaching quality,promoting teachers’professional development,driving social services,and enhancing the college’s core competitiveness.At the same time,addressing the existing problems in current scientific research work at higher vocational colleges,this paper proposed innovative pathways focusing on the scientific research management system,scientific research team construction,scientific research funding investment,and scientific research outcome transformation.The aim is to provide valuable references for the scientific research development of higher vocational colleges.
文摘Discussions on Chinese modernization are offering African countries both conceptual inspiration and practical references as they explore their own sustainable development paths.
文摘Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6.
基金supported by the National Natural Science Foundation of China(No.81774281 and No.82474303)the Natural Science Foundation of Hunan Province(2023JJ30888)the leading national joint discipline of Chinese and Western medicines to the Chinese Medicine Department,Xiangya Hospital,CSU.
文摘Objective:To identify promising biomarkers for the pathogenesis of major depressive disorder(MDD).Methods:Microarray chips of MDD patients,including the GSE98793,GSE52790,and GSE39653 datasets,were obtained from the Gene Expression Omnibus database.The biological processes and pathways related to MDD were investigated using the GO and KEGG pathway tools.Weighted gene coexpression network analysis was conducted to identify modules related to MDD.The hub genes associated with MDD were obtained via protein-protein interaction analysis.Finally,the expression of hub genes in the hippocampal tissues of depression-like rats was detected by reverse transcription-polymerase chain reaction and Western blotting.Results:A total of 658 differentially expressed genes were identified from the Gene Expression Omnibus datasets;thus,these genes and the GSE98793 dataset were used to conduct weighted gene coexpression network analysis.A total of 244 module-related genes were identified and these genes were highly correlated with MDD.These genes were involved in the Ras signaling pathway,regulation of the actin cytoskeleton,and axon guidance according to the KEGG analysis.Hub genes,including MAPK14,SOCS1,TLR2,PTK2B,and GRB2,were obtained via protein-protein interaction analysis.All these hub genes showed better diagnostic efficiency in the GSE52790,GSE39653,and GSE98793 datasets.In vivo experiments revealed that compared with those in control rats,SOCS1 and MAPK14 expression was significantly decreased;while GRB2,TLR2,and PTK2B expression was increased in the hippocampi of depression-like rats.Conclusions:Our study demonstrates that GRB2,TLR2,SOCS1,PTK2B,and MAPK14 are promising hub genes,and targeting these five genes may be an effective treatment strategy for MDD.
基金Supported by The Sanming Project of Medicine in Shenzhen,No.SZSM202211003Shenzhen-Hong Kong Jointly Funded Project,Shenzhen Science and Technology Program,No.SGDX20230116093645007+1 种基金Shenzhen Second People's Hospital Clinical Project,No.20243357003Shenzhen Medical Research Fund,No.B2303005.
文摘BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.
基金Financial supports from the National Natural Science Foundation of China(GrantNo.52374123&51974144)Project of Liaoning Provincial Department of Education(GrantNo.LJKZ0340)Liaoning Revitalization Talents Program(Grant No.XLYC2211085)are greatly acknowledged.
文摘Q-learning is a classical reinforcement learning method with broad applicability.It can respond effectively to environmental changes and provide flexible strategies,making it suitable for solving robot path-planning problems.However,Q-learning faces challenges in search and update efficiency.To address these issues,we propose an improved Q-learning(IQL)algorithm.We use an enhanced Ant Colony Optimization(ACO)algorithmto optimizeQtable initialization.We also introduce the UCH mechanism to refine the reward function and overcome the exploration dilemma.The IQL algorithm is extensively tested in three grid environments of different scales.The results validate the accuracy of themethod and demonstrate superior path-planning performance compared to traditional approaches.The algorithm reduces the number of trials required for convergence,improves learning efficiency,and enables faster adaptation to environmental changes.It also enhances stability and accuracy by reducing the standard deviation of trials to zero.On grid maps of different sizes,IQL achieves higher expected returns.Compared with the original Q-learning algorithm,IQL improves performance by 12.95%,18.28%,and 7.98% on 10*10,20*20,and 30*30 maps,respectively.The proposed algorithm has promising applications in robotics,path planning,intelligent transportation,aerospace,and game development.
